JPS57144252A - Preparation of aminoalkylthiol - Google Patents

Preparation of aminoalkylthiol

Info

Publication number
JPS57144252A
JPS57144252A JP56029438A JP2943881A JPS57144252A JP S57144252 A JPS57144252 A JP S57144252A JP 56029438 A JP56029438 A JP 56029438A JP 2943881 A JP2943881 A JP 2943881A JP S57144252 A JPS57144252 A JP S57144252A
Authority
JP
Japan
Prior art keywords
reaction
compound
mercaptothiazoline
aminoalkylthiol
conversion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56029438A
Other languages
Japanese (ja)
Other versions
JPH0217544B2 (en
Inventor
Kozo Iwasaki
Hiromi Inagaki
Nobumi Kusuhara
Shigeo Makino
Hiroshi Iida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP56029438A priority Critical patent/JPS57144252A/en
Publication of JPS57144252A publication Critical patent/JPS57144252A/en
Publication of JPH0217544B2 publication Critical patent/JPH0217544B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: To shorten the reaction time, and to improve the purity of the product in the preparation of an aminoalkylthiol useful as a raw material of pharmaceuticals by the hydrolysis of 2-mercaptothiazoline compound, by terminating the reaction at a specific range of conversion.
CONSTITUTION: The objective compound of formula II (R1, R2, R3 and R4 are H, lower alkyl or hydroxy-substituted lower alkyl) is prepared in high purity, by hydrolyzing a 2-mercaptothiazoline compound of formulaIwith a hydrohalogenic acid (HX), terminating the reaction when the conversion reaches 80W95%, and recrystallizing the resultant crude aminoalkylthiol with an organic solvent. The hydrohalogenic acid is e.g. hydrofluoric acid, hydrochloric acid, etc., and its amount is 4W8mol per 1mol of the 2-mercaptothiazoline compound.
EFFECT: The hydrolytic conversion of as high as 80W95% can be attained easily by suppressing the successive reaction through intermediates and carrying out the direct reaction preferentially.
COPYRIGHT: (C)1982,JPO&Japio
JP56029438A 1981-03-03 1981-03-03 Preparation of aminoalkylthiol Granted JPS57144252A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56029438A JPS57144252A (en) 1981-03-03 1981-03-03 Preparation of aminoalkylthiol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56029438A JPS57144252A (en) 1981-03-03 1981-03-03 Preparation of aminoalkylthiol

Publications (2)

Publication Number Publication Date
JPS57144252A true JPS57144252A (en) 1982-09-06
JPH0217544B2 JPH0217544B2 (en) 1990-04-20

Family

ID=12276131

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56029438A Granted JPS57144252A (en) 1981-03-03 1981-03-03 Preparation of aminoalkylthiol

Country Status (1)

Country Link
JP (1) JPS57144252A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075511A (en) * 1986-10-30 1991-12-24 Shell Oil Company Process and alkylmercaptoamine catalyst for production of bisphenol-A
US5256362A (en) * 1989-07-14 1993-10-26 Nippon Shokubai Co., Ltd. Method for production of granular cysteamine hydrochloride
CN108658818A (en) * 2018-04-27 2018-10-16 韶关凌化工有限公司 A kind of preparation method of Mercaptamine
CN109503441A (en) * 2017-09-15 2019-03-22 阜新达得利化工股份有限公司 The preparation method of high-content Mercaptamine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JàORGàCHEM *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075511A (en) * 1986-10-30 1991-12-24 Shell Oil Company Process and alkylmercaptoamine catalyst for production of bisphenol-A
US5256362A (en) * 1989-07-14 1993-10-26 Nippon Shokubai Co., Ltd. Method for production of granular cysteamine hydrochloride
CN109503441A (en) * 2017-09-15 2019-03-22 阜新达得利化工股份有限公司 The preparation method of high-content Mercaptamine
CN108658818A (en) * 2018-04-27 2018-10-16 韶关凌化工有限公司 A kind of preparation method of Mercaptamine
CN108658818B (en) * 2018-04-27 2020-05-12 韶关凌一化工有限公司 Preparation method of cysteamine hydrochloride

Also Published As

Publication number Publication date
JPH0217544B2 (en) 1990-04-20

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