JPS5536431A - Preparation of farnesylacetic acid - Google Patents

Preparation of farnesylacetic acid

Info

Publication number
JPS5536431A
JPS5536431A JP11004978A JP11004978A JPS5536431A JP S5536431 A JPS5536431 A JP S5536431A JP 11004978 A JP11004978 A JP 11004978A JP 11004978 A JP11004978 A JP 11004978A JP S5536431 A JPS5536431 A JP S5536431A
Authority
JP
Japan
Prior art keywords
formula
nerolyl
reacting
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11004978A
Other languages
Japanese (ja)
Other versions
JPS6140214B2 (en
Inventor
Masaki Ogawa
Teruo Komoto
Wataichi Mogi
Susumu Sato
Tadayuki Kuraishi
Tatsuhiko Katori
Toshiaki Nakajima
Yoshichika Odaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Priority to JP11004978A priority Critical patent/JPS5536431A/en
Publication of JPS5536431A publication Critical patent/JPS5536431A/en
Publication of JPS6140214B2 publication Critical patent/JPS6140214B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as a raw material of an anti-ulcer agent, easily, in high yield, by heating nerolyl alkyl malonate and aluminum isopropoxide, and hydrolyzing and decarbonating the reaction product.
CONSTITUTION: The objective compound of formula IV is prepared by (1) reacting nerolyl acetate of formula I with lithium dialkylamide in an inert solvent such as tetrahydrofuran at -50W-80°C, (2) reacting the resulting lithium derivative with an alkyl chlorocarbonate to obtain a nerolyl alkyl malonate of formula II, (3) reacting the compound II with aluminum isopropoxide at 140W150°C in the absence of solvent, (4) hydrolyzing the resulting farnesylmalonic acid alkyl ester with an alkali to afford farnesylmalonic acid of formula III, and (5) decarbonating the compound III by heating, e.g. at 150°C under reduced pressure.
COPYRIGHT: (C)1980,JPO&Japio
JP11004978A 1978-09-07 1978-09-07 Preparation of farnesylacetic acid Granted JPS5536431A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11004978A JPS5536431A (en) 1978-09-07 1978-09-07 Preparation of farnesylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11004978A JPS5536431A (en) 1978-09-07 1978-09-07 Preparation of farnesylacetic acid

Publications (2)

Publication Number Publication Date
JPS5536431A true JPS5536431A (en) 1980-03-14
JPS6140214B2 JPS6140214B2 (en) 1986-09-08

Family

ID=14525797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11004978A Granted JPS5536431A (en) 1978-09-07 1978-09-07 Preparation of farnesylacetic acid

Country Status (1)

Country Link
JP (1) JPS5536431A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754913A (en) * 1986-06-27 1988-07-05 Norsk Hydro A.S. Method of joining zinc coated aluminum members and uncoated aluminum members

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754913A (en) * 1986-06-27 1988-07-05 Norsk Hydro A.S. Method of joining zinc coated aluminum members and uncoated aluminum members

Also Published As

Publication number Publication date
JPS6140214B2 (en) 1986-09-08

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