JPS5686184A - Novel mitomycin c derivative - Google Patents

Novel mitomycin c derivative

Info

Publication number
JPS5686184A
JPS5686184A JP16392079A JP16392079A JPS5686184A JP S5686184 A JPS5686184 A JP S5686184A JP 16392079 A JP16392079 A JP 16392079A JP 16392079 A JP16392079 A JP 16392079A JP S5686184 A JPS5686184 A JP S5686184A
Authority
JP
Japan
Prior art keywords
mitomycin
formula
derivative
hydroxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16392079A
Other languages
Japanese (ja)
Other versions
JPS6157315B2 (en
Inventor
Hiromasa Kato
Chikahiro Urakawa
Kinichi Nakano
Ryoji Imai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP16392079A priority Critical patent/JPS5686184A/en
Publication of JPS5686184A publication Critical patent/JPS5686184A/en
Publication of JPS6157315B2 publication Critical patent/JPS6157315B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I (X is o-hydroxy, m-hydroxy or p-chloro group).
EXAMPLE: 7a-N-(p-Chlorophenyl)-mitomycin C.
PROCESS: A mitomycin A of formula II is reacted with p-chloroaniline or m-aminophenol in a suitable solvent at -30 to 50°C for 30W50hr, and the reaction product is purified from the reaction mixture by the well-known method, e.g. column chromatography with silica gel, to give the compound of formula I. Preferably, the molar ratio between the mitomycin A and the amine is 1:100W3:1, and the concentration of the mitomycin A is 10-6W10-5mol/l.
COPYRIGHT: (C)1981,JPO&Japio
JP16392079A 1979-12-17 1979-12-17 Novel mitomycin c derivative Granted JPS5686184A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16392079A JPS5686184A (en) 1979-12-17 1979-12-17 Novel mitomycin c derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16392079A JPS5686184A (en) 1979-12-17 1979-12-17 Novel mitomycin c derivative

Publications (2)

Publication Number Publication Date
JPS5686184A true JPS5686184A (en) 1981-07-13
JPS6157315B2 JPS6157315B2 (en) 1986-12-06

Family

ID=15783328

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16392079A Granted JPS5686184A (en) 1979-12-17 1979-12-17 Novel mitomycin c derivative

Country Status (1)

Country Link
JP (1) JPS5686184A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57188590A (en) * 1981-05-15 1982-11-19 University Patents Inc Novel mitomycin derivative
JPS58106868A (en) * 1981-12-18 1983-06-25 Hitachi Ltd Insulated gate type field-effect semiconductor device and manufacture thereof
JPS59152384A (en) * 1983-02-07 1984-08-31 ユニヴア−シテイ　パテンツ，インコ−ポレイテツド Mitomycin analogue

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57188590A (en) * 1981-05-15 1982-11-19 University Patents Inc Novel mitomycin derivative
JPS58106868A (en) * 1981-12-18 1983-06-25 Hitachi Ltd Insulated gate type field-effect semiconductor device and manufacture thereof
JPS59152384A (en) * 1983-02-07 1984-08-31 ユニヴア−シテイ　パテンツ，インコ−ポレイテツド Mitomycin analogue

Also Published As

Publication number Publication date
JPS6157315B2 (en) 1986-12-06

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