JPS5622747A - Novel bicyclooctane derivative and its preparation - Google Patents

Novel bicyclooctane derivative and its preparation

Info

Publication number
JPS5622747A
JPS5622747A JP9879879A JP9879879A JPS5622747A JP S5622747 A JPS5622747 A JP S5622747A JP 9879879 A JP9879879 A JP 9879879A JP 9879879 A JP9879879 A JP 9879879A JP S5622747 A JPS5622747 A JP S5622747A
Authority
JP
Japan
Prior art keywords
formula
hydroxy
aryl
protecting group
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9879879A
Other languages
Japanese (ja)
Inventor
Akihiko Sugie
Hajime Kawakami
Keiichi Ono
Sumimoto Katsube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP9879879A priority Critical patent/JPS5622747A/en
Publication of JPS5622747A publication Critical patent/JPS5622747A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A bicyclooctane derivative shown by the formula I(R is lower alkyl, lower aralkyl, or aryl; R1 is H or lower alkyl; X is vinylene or ethylene; Z is lower alkylene.).
EXAMPLE: 2β-( 4'-Amyloxy-3'-hydroxy-trans-1'-butenyl )-3α-hydroxy-7-( 4'carboxybutylidene)bicyclo[3,3,0]octane.
USE: Having strong inhibiting action on platelet aggregation. A drug useful for diseases, e.g., cerebral thrombosis, cerebral apoplexy, etc. PRECESS:1mol of a compound shown by the formula II (Y is H or hydroxy-protecting group) is reacted with 1W10mol of a Wittig reagent shown by the formula III (M is H or alkali metal; R' is aryl) in the presence of a solvent, e.g., diethyl ether, preferably at room temperature, the protecting group is removed when hydroxyl group is protected, and the resulting compound is esterified, if necessary, to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP9879879A 1979-08-01 1979-08-01 Novel bicyclooctane derivative and its preparation Pending JPS5622747A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9879879A JPS5622747A (en) 1979-08-01 1979-08-01 Novel bicyclooctane derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9879879A JPS5622747A (en) 1979-08-01 1979-08-01 Novel bicyclooctane derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5622747A true JPS5622747A (en) 1981-03-03

Family

ID=14229366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9879879A Pending JPS5622747A (en) 1979-08-01 1979-08-01 Novel bicyclooctane derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5622747A (en)

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