JPS56120669A - Allophanoylpiperazine compound and analgesic agent containing the same as active constituent - Google Patents

Allophanoylpiperazine compound and analgesic agent containing the same as active constituent

Info

Publication number
JPS56120669A
JPS56120669A JP2447380A JP2447380A JPS56120669A JP S56120669 A JPS56120669 A JP S56120669A JP 2447380 A JP2447380 A JP 2447380A JP 2447380 A JP2447380 A JP 2447380A JP S56120669 A JPS56120669 A JP S56120669A
Authority
JP
Japan
Prior art keywords
compound
formula
active constituent
analgesic agent
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2447380A
Other languages
Japanese (ja)
Other versions
JPS625429B2 (en
Inventor
Hajime Fujimura
Yasuzo Hiramatsu
Takahiro Yabuuchi
Masakatsu Kuki
Katsuo Takigawa
Takatsugu Honna
Hidekazu Miyake
Akira Kajitani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Original Assignee
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Production Development, Zaidan Hojin Seisan Kaihatsu Kenkyusho filed Critical Research Institute for Production Development
Priority to JP2447380A priority Critical patent/JPS56120669A/en
Publication of JPS56120669A publication Critical patent/JPS56120669A/en
Publication of JPS625429B2 publication Critical patent/JPS625429B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound expressed by formula I (R1 is lower alkyl or phenyl; R2 and R3 are H or lower alkyl; R4 is phenyl, pyridyl, thiazolyl, benzyl, etc. having a substituent, e.g. phenyl or alogen, CH3, CF3, OH, OCH3, etc.).
EXAMPLE: 1-(2,4-Dimethylallophanoyl)-4-phenylpiperazine.
USE: An analgesic agent having an anti-inflammatory action, and administered in a dose of 1W500mg/adult/day as an active constituent divided 1W4 times.
PROCESS: An allophanoyl chloride of formula II is reacted with a piperazine of formula III in a solvent, e.g. dichloromethane, if necessary in the presence of a condensing assistant, e.g. a basic compound, at -20W50°C to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP2447380A 1980-02-27 1980-02-27 Allophanoylpiperazine compound and analgesic agent containing the same as active constituent Granted JPS56120669A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2447380A JPS56120669A (en) 1980-02-27 1980-02-27 Allophanoylpiperazine compound and analgesic agent containing the same as active constituent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2447380A JPS56120669A (en) 1980-02-27 1980-02-27 Allophanoylpiperazine compound and analgesic agent containing the same as active constituent

Publications (2)

Publication Number Publication Date
JPS56120669A true JPS56120669A (en) 1981-09-22
JPS625429B2 JPS625429B2 (en) 1987-02-04

Family

ID=12139128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2447380A Granted JPS56120669A (en) 1980-02-27 1980-02-27 Allophanoylpiperazine compound and analgesic agent containing the same as active constituent

Country Status (1)

Country Link
JP (1) JPS56120669A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502623A (en) * 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ Substituted piperazines and diazepanes
JP2008505149A (en) * 2004-07-05 2008-02-21 グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Substituted 1-propioyl piperazine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502623A (en) * 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ Substituted piperazines and diazepanes
JP2008505149A (en) * 2004-07-05 2008-02-21 グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Substituted 1-propioyl piperazine

Also Published As

Publication number Publication date
JPS625429B2 (en) 1987-02-04

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