JPH09175966A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity having high chemical cleaning effect. SOLUTION: This composition is obtained by blending >=3wt.% water-soluble pyrophosphoric acid salt, one or more kinds of straight-chain and cyclic water- soluble polyphosphoric acid salts represented by the formula Mn+2 Pn O3n+1 and the formula (MPO3 )m (M is Na or K; (m) and (n) are each >=3) in an amount of 20-100wt.% based on the water-soluble pyrophosphoric acid salt with a composition for oral cavity composed of components not releasing calcium ion and controlling pH of the blend to pH6-10. The composition is prepared into a dentifrice such as a toothpaste, a mouth rinsing agent, a troche, a chewing gum, etc., and used. The composition effectively removes stain of tooth surface, e.g. stain plaque or tobacco tar by chemical action and enables cleaning of a part which tooth brush does not reach and increases beautifying and whitening effect of tooth surface. Further, since the composition has excellent cleaning effect, the composition can reduce blend amount of polisher when dentifrice is prepared.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having a high chemical cleaning effect.

[0002]

2. Description of the Related Art
Stains, plaques, food scraps that have adhered / deposited on the tooth surface,
BACKGROUND ART Tooth stains such as tobacco tar have been removed by a mechanical action of an abrasive compounded in an oral composition such as toothpaste.

That is, stains such as food residue attached or deposited on the tooth surface are removed by brushing the tooth surface with an oral composition such as toothpaste and a toothbrush, but the part that the toothbrush cannot reach is cleaned. There is also a problem that you cannot do it.

For this reason, the following proposals have been made to remove the stains on the tooth surface not only by mechanical action but by chemical action, but the effect is not always sufficient, and At present, most of the removal of dirt depends on mechanical action. (1) A composition for oral cavity containing a specific organic peroxide (US Pat. No. 3,988,433). (2) A composition for oral cavity in which a cationic surfactant and malic acid are used in combination (US Pat. No. 4,183,916). (3) A composition for oral cavity containing an ester having an aromatic ring (Japanese Patent Publication No. 48-43869). (4) A composition for oral cavity containing a chelating agent having a stability coefficient of Fe> Ca (JP-A-51-139639). (5) A composition for oral cavity in which a polyphosphate and a polyvalent metal cation are used in combination (JP-A-52-108029). (6) A composition for oral cavity in which phytic acid and an organic acid are used in combination (JP-A-56-18911). (7) Tartronic acid, glyceric acid, hydroxy-n-
A composition for oral cavity containing butyric acid and dihydroxymalonic acid (JP-A-60-4117). (8) A composition for oral cavity in which carvone, anethole or 3-octanol is used in combination with a solvent extract of astragalus plants (JP-A-61-286315). (9) A composition for oral cavity containing 2-octanol (JP-A-62-151498). (10) A composition for oral cavity containing a specific monoterpene (JP-A-62-181212). (11) A composition for oral cavity containing an aliphatic ester having a total of 7 to 11 carbon atoms (JP-A-62-189233). (12) A composition for oral cavity containing citric acid, polyphosphoric acid and a nonionic surfactant (JP-A-7-126131).
issue). (13) Oral composition containing polyphosphate, orthophosphate and anionic surfactant (Japanese Patent Application No. 7-18483)
No. 8). (14) Composition for oral cavity containing polyphosphate, orthophosphate and amphoteric surfactant (Japanese Patent Application No. 7-184839)
issue).

[0005] The present invention has been made in view of the above circumstances,
An object is to provide an oral composition having a high chemical cleaning effect.

[0006]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of intensive investigations aimed at achieving the above object, the present inventors have found that an oral composition comprising a component that does not release calcium ions is water-soluble. Pyrrophosphate is blended in an amount of 3% by weight or more based on the whole composition, and the following general formula (1)
And (2) M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (wherein M represents Na or K, and m and n are integers of 3 or more, respectively). When one or more selected from linear and cyclic water-soluble polyphosphates represented by the formula (1) are used together in a proportion of 20 to 100% by weight based on the aqueous solution pyrophosphate, tooth stains are It was found that the action of chemically removing is significantly increased, and stains such as stains, plaques and tobacco tar can be effectively removed by the chemical action,
The present invention has been accomplished.

It is known to mix a water-soluble pyrophosphate and a water-soluble polyphosphate in an oral composition (JP-A-1-131111, JP-A-2-32010).
JP-A-2-59512 and JP-A-5-39213.
JP-A No. 7-10726), these proposals relate to the removal of tartar and the stabilization of soluble fluoride ions, and a component that does not release calcium ions at a specific mixing ratio of pyrophosphate and polyphosphate. The present inventors have found for the first time that the effect of chemically removing tooth stains is remarkably increased by blending it with an oral composition comprising

The present invention will be described in more detail below. The oral composition of the present invention is, as described above, a mixture of a water-soluble pyrophosphate and an aqueous solution polyphosphate in a specific amount and a specific ratio.

Here, as the water-soluble pyrophosphate used in the present invention, tetrasodium pyrophosphate, sodium acid pyrophosphate, potassium pyrophosphate and the like are used. These pyrophosphate salts may be used alone or in admixture of two or more.

The content of the above-mentioned pyrophosphate in the oral composition of the present invention is 3% by weight or more, preferably 3-10% by weight, particularly 3-7% by weight, based on the total amount of the composition.
Is preferred. If the blending amount is less than 3% by weight, a sufficient stain cleaning effect cannot be obtained even when the polyphosphate salt of the present invention is used in combination, and the object of the present invention cannot be achieved. If it exceeds 10% by weight, the crystals of pyrophosphate which cannot be completely dissolved may deteriorate the appearance of the oral composition or make the feel of the composition uncomfortable to use.

The water-soluble polyphosphate used in the present invention is represented by the following formula (1) M _{n + 2} P _n O _{3n + 1} (1) (where M is Na or K, and n ≧ 3). , Such as sodium tripolyphosphate or potassium tripolyphosphate with a degree of polymerization n = 3, sodium tetrapolyphosphate or potassium tetrapolyphosphate with a degree of polymerization n = 4, sodium metaphosphate or potassium metaphosphate with a high degree of polymerization, and the like. Linear polyphosphates, and those represented by the following formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3), that is, the degree of polymerization m = 3 rings of sodium trimetaphosphate or potassium trimetaphosphate, m = 4 sodium tetrametaphosphate or potassium tetrametaphosphate, m = 6 sodium hexametaphosphate or potassium hexametaphosphate Polyphosphate is used for.

These polyphosphates may be used alone or in admixture of two or more, and among these, linear polyphosphates are preferred.

The amount of the above polyphosphate salt compounded in the oral composition of the present invention is 0.2 to 1 times the weight of the above pyrophosphate salt, preferably 0.2 to 0.75 times the weight, and more preferably 0. A weight of 2 to 0.5 times is preferable. The above amount is 0.2
If it is less than double weight or more than 1 weight, even if it is used in combination with the pyrophosphate of the present invention, a sufficient stain cleaning effect cannot be obtained, and the object of the present invention cannot be achieved.

The oral composition of the present invention is prepared as dentifrice such as toothpaste, mouthwash, troche, chewing gum and the like,
As applied, in this case the composition of the invention is prepared using components which do not release calcium ions, in addition to the pyrophosphate and polyphosphate described above. When a component that releases calcium ions, for example, a polishing base such as calcium hydrogen phosphate or calcium carbonate is included, the released calcium ions inactivate pyrophosphate and polyphosphate, impairing their chemical detergency. Therefore, the object of the present invention cannot be achieved.

Therefore, the oral composition of the present invention uses appropriate components according to its type. For example, in the case of toothpaste, an abrasive, a binder, a thickener, a surfactant, A sweetener, an antiseptic, a fragrance, various active ingredients and the like can be mixed and produced according to a conventional method, but a base or ingredient that releases calcium ions is not used.

Specifically, examples of the abrasive include crystalline silica, amorphous silica, other silica-based abrasives, aluminosilicate, aluminum oxide, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, Titanium oxide, synthetic resin, etc. are preferably used,
These abrasives may be used alone or in combination of two or more kinds (usually 3 to 90% by weight).

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose,
Alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, gums such as karaya gum and gum arabic, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinyl pyrrolidone and other synthetic binders, gelling property One or more kinds of inorganic binders such as silica, gelling aluminum silica, bee gum and laponite may be blended (the compounding amount is usually 0.5 to 10% by weight).

As the thickener, sorbit, glycerin, ethylene glycol, propylene glycol, 1,
One or more kinds of 3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lactit and the like may be blended (the compounding amount is usually 1 to 50% by weight).

As the surfactant, water-soluble salts of higher alkyl sulfates having an alkyl group having 8 to 18 carbon atoms such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl monoglyceride sulfonate, and coconut monoglyceride sulfonic acid. Water-soluble salts of higher fatty acid monoglyceride sulfonic acid having 10 to 18 carbon atoms in fatty acid groups such as sodium, olefin sulfonic acid, paraffin sulfonic acid, other anion activators, stearyl monoglyceride, sucrose mono and dilaurate fatty acid groups Has 12 to 1 carbon atoms
8 sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene hydrogenated castor oil, sorbitan monostea with about 60 mol of ethylene glycol added A nonionic surfactant such as a rate condensate, a polymer of ethylene oxide and propylene oxide, or a derivative such as polyoxyethylene polyoxypropylene monolauryl ester, and a surfactant such as an amphoteric surfactant of betaine type or amino acid type are used. The amount is usually 0.01 to 7% by weight).

Further, as a sweetener, saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium cyclamate, etc., antiseptic. P-Hydroxymethyl benzoic acid, p-Hydroxyethyl benzoic acid, p-Hydroxypropyl benzoic acid, p-Hydroxybutyl benzoic acid, sodium benzoate, lower fatty acid monoglyceride, etc. as a fragrance, wintergreen oil, spearmint Oils, peppermint oil, sassafras oil, clove oil, eucalyptus oil and the like may be included. Further, gelatin, peptone, arginine hydrochloride, albumin, whitening agent, silicone, dye and other components may be added. Furthermore, epsilon amine caproic acid, tranexamic acid, dextranase,
Amylase, protease, mutanase, lysozyme,
Lytic enzymes, enzymes such as retechenzyme, sodium monofluorophosphate, alkali metal monofluorophosphates such as potassium monofluorophosphate, sodium fluoride, fluorides such as ammonium fluoride, chlorhexidine salts, dihydrocholesterol, glycyrrhetin salts, glycyrrhetin One or more active ingredients such as acid, chlorophyll, caropeptide, vitamins, anticalculus agent, antibacterial agent, antiplaque agent, and hypersensitizer such as potassium nitrate may be blended.

The pH of the oral composition of the present invention is not particularly limited, but is preferably 6 to 10 from the viewpoint of the stability of pyrophosphate and polyphosphate and the irritation of oral mucosa, and particularly 6.5 to 9. Is preferred.

[0022]

EFFECTS OF THE INVENTION The oral composition according to the present invention can effectively remove stains on tooth surfaces such as stains, plaques and tars of cigarettes by a chemical action, and can also clean a portion that the toothbrush cannot reach. Yes, the whitening effect on the tooth surface is increased. Further, since the cleaning effect of the oral composition is extremely high, the compounding amount of the abrasive can be reduced when preparing toothpaste.

[0023]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples.

[Experimental Example] A hydroxyapatite disc (HA plate, the same applies hereinafter, Asahi Optical Co., Ltd., 7 × 3 mm) was fixed to a mouthpiece, and mounted in the oral cavity (lower jaw tongue side part) to give H.
A pellicle was formed on the A plate. This was placed in an apparatus for alternately immersing it in a stain solution and drying in air, and operated for 24 hours to attach stain to the HA plate surface. The composition of the stain solution is as follows. In addition, all the following% show weight%. Stain solution composition Ferrous chloride n-hydrate 0.05% Instant coffee 0.37% Instant black tea 0.37% The stain-attached HA plate was immersed in the sample solution shown in Table 1 for 5 minutes, and reciprocating brushing was repeated 5 times. After that, the pellicle stained with a 10% phloxine solution was stained to measure the color difference (Lab color system). This removing operation (immersion → brushing → color difference measurement) was repeated until the stain was completely removed (until the color difference of the HA plate became equal to that before the stain was attached). It was evaluated that the smaller the number of times of brushing, the higher the chemical removing power. The results are shown in Table 1.

[0025]

[Table 1]

From the results shown in Table 1, it was confirmed that 3
It has been found that the chemical cleaning power of stain is specifically enhanced by adding 20 to 100% by weight of a water-soluble polyphosphate to the above-mentioned water-soluble pyrophosphate in a system containing at least 50% by weight.

Examples will be shown below. [Example 1] Toothpaste Precipitable silica 30.0% Propylene glycol 3.0 Sorbitol 20.0 Sodium carboxymethyl cellulose 1.4 Sodium saccharin 0.1 Stevioside 0.1 Potassium glycyrrhizinate 1.0 Sodium lauryl sulfate 0.5 N- Sodium lauroyl glutamate 0.5 Tranexamic acid 0.05 α-alumina anhydride 3.0 Colloidal silica 3.0 Methylparaben 0.05 Perfume 1.0 Potassium pyrophosphate 5.0 Sodium tripolyphosphate 3.0 Water balance 100. 0%

Example 2 Toothpaste Modified Aluminum Hydroxide 18.0% Propylene Glycol 2.0 Sorbit 20.0 Hydroxyethyl Cellulose Sodium 1.4 Saccharin Sodium 0.1 Sodium Lauryl Sulfate 0.5 Sodium Lauryl POE Sulfate 0.5 Colloidal silica 3.0 Sodium monofluorophosphate 0.76 Chlorhexidine gluconate 0.1 Methylparaben 0.05 Perfume 1.0 Sodium pyrophosphate 3.0 Sodium tetrapolyphosphate 1.0 Dipotassium hydrogen phosphate 0.5 Water Balance 100.0%

[Example 3] Toothpaste Silicic anhydride 30.0% Titanium oxide 0.5 Carboxymethylcellulose sodium 1.1 Carrageenan 0.2 Sodium lauryl sulfate 1.4 Sorbit solution 20.0 Glycerin 20.0 Propylene glycol 3. 0 Methylparaben 0.05 Sodium saccharin 0.15 Perfume 1.0 Sodium pyrophosphate 4.0 Sodium hexametaphosphate 1.2 Water Residual 100.0%

Example 4 Liquid Toothpaste Silica Anhydrous 15.0% 60% Solbit Solution 25.0 Glycerin 25.0 Propylene Glycol 5.0 Xanthan Gum 0.2 N-Sodium Lauroyl Glutamate 0.5 Sodium Lauryl Sulfate 0. 5 Carrageenan 0.5 Alginic acid 1.0 Sodium fluoride 0.22 Dextranase (1 million U / g) 0.5 Saccharin sodium 0.1 Perfume 1.0 Sodium pyrophosphate 3.0 Ultra polyphosphate sodium 1.2 Water Balance 100.0%

Example 5 Dental Cream Sorbitol 20.0% Propylene Glycol 2.5 Sodium Lauryl Sulfate 1.0 Sodium Carboxymethyl Cellulose 1.0 Sodium Saccharin 0.1 Sodium Paraoxybenzoate 0.1 Perfume 0.8 Sodium Pyrophosphate 3.0 Sodium tripolyphosphate 2.0 Sodium dihydrogen phosphate 0.5 Water Residual total 100.0%

[Example 6] Dental cream Sorbitol 20.0% Propylene glycol 3.0 Sodium lauryl sulfate 1.0 Sodium carboxymethyl cellulose 2.5 Saccharin sodium 0.1 Ethyl paraoxybenzoate 0.1 Perfume 0.8 Sodium pyrophosphate 4.0 Sodium ultrapolyphosphate 0.8 water Residual total 100.0%

Example 7 Mouthwash Ethanol 10.0% Saccharin sodium 0.05 Sodium monofluorophosphate 0.05 Chlorhexidine gluconate 0.01 Dye 0.01 Sodium benzoate 0.05 Antioxidant 0.01 Fragrance 0.3 Sodium lauryl sulfate 0.3 POE Sodium myristyl sulfate 0.3 Potassium pyrophosphate 2.5 Sodium tetrapolyphosphate 2.0 Water Residual 100.0%

[Example 8] Tablet for gargle Sodium hydrogencarbonate 55.0% Polyethylene glycol 400 3.0 Fragrance 1.0 Oleic acid 0.1 Chlorhexidine hydrochloride 0.05 Citric acid 17.0 Sodium pyrophosphate 6.5 Hexametaline Sodium acid 6.5 Water Residual 100.0%

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Isao Minemoto 1-3-7 Honjo, Sumida-ku, Tokyo Lion Corporation

Claims (1)

[Claims] 1. An oral composition comprising a component that does not release calcium ions, containing 3% by weight or more of a water-soluble pyrophosphate salt in the entire composition, and _{Mn + represented by the following} general formulas (1) and (2). ₂ P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (wherein M represents Na or K, and m and n are each an integer of 3 or more) And 20 to 100% by weight of one or more cyclic water-soluble polyphosphate salts with respect to the aqueous pyrophosphate salt composition.