JP6424031B2 - Melting equipment - Google Patents

Description

  The present invention relates to a dissolution apparatus for dissolving a powder drug for dialysis to obtain a stock solution for dialysis.

  Dialysis fluids used for the treatment of patients with renal failure in hospitals are generally divided into bicarbonate and acetic acid. Of these, bicarbonate-based dialysate does not contain sodium bicarbonate (hereinafter referred to as “bicarbonate”). It is prepared by mixing water with two types of drugs, called A agent and sodium bicarbonate (hereinafter referred to as B agent). In recent years, from the viewpoint of improving transportability, attempts have been made to dissolve these A agent and B agent powder (hereinafter referred to as “dialysis powder drug”) before dialysis treatment time. As for the solution (especially B agent), the concentration was likely to decrease over time, and it was difficult to prepare a large amount of solution.

  For this reason, dissolution work is required for each dialysis treatment, and various dissolution apparatuses for dissolution have been proposed. For example, Patent Document 1 discloses a melting apparatus provided with two melting tanks. With this configuration, after completion of dialysis, a powder drug for dialysis is put in advance in one dissolution tank for the next dialysis, and the other dissolution tank is washed and disinfected until the next dialysis is started. It can be carried out. Further, during the dialysis, while the dialysate stock solution is supplied from one dissolution tank to the artificial dialysate supply device, the powder drug for dialysis can be additionally dissolved in the other dissolution tank.

JP 2001-9028 A

  However, in the above prior art, it was difficult to determine whether or not the dialysis powder drug remained undissolved in the dialysis stock solution agitated and generated in the dissolution tank. There was a risk of liquid feeding. In addition, it is conceivable to measure the conductivity of the dialysis stock solution produced by stirring and detect the undissolved residue of the dialysis powder drug based on the measured value. For example, for the dialysis stock solution generated from the agent A, Since the change in conductivity is very small with respect to the actual concentration change, it becomes difficult to detect the undissolved residue.

  The present invention has been made in view of such circumstances, and can accurately determine whether or not the dialysis powder drug remains undissolved in the dialysis stock solution agitated and generated in the dissolution tank. It is to provide a melting apparatus.

  The invention described in claim 1 is a dissolution apparatus for dissolving a dialysis powder drug to obtain a dialysis stock solution, a dissolution tank capable of containing the dialysis powder drug, and the dialysis powder drug in the dissolution tank. Water supply line for supplying water for dissolution, stirring means for stirring the solution in the dissolution tank, and the level of water or solution supplied in the dissolution tank can be detected continuously and in real time Liquid level detection means, and determination means capable of determining whether or not the dialysis powder drug remains undissolved in the solution generated in the dissolution tank based on the liquid level detected by the liquid level detection means. It is characterized by having.

  According to a second aspect of the present invention, in the dissolution apparatus according to the first aspect, the determination means detects the theoretical value of the liquid level when the dialysis powder drug is completely dissolved in water and the liquid level detection means. The measured value of the liquid level is compared, and the presence or absence of the undissolved portion of the powder drug for dialysis can be determined from the difference between the theoretical value of the liquid level and the measured value.

  According to a third aspect of the present invention, in the dissolution apparatus according to the second aspect, the determination means can calculate a residual amount of dissolution of the powder drug for dialysis from a difference between a theoretical value and an actual measurement value of the liquid level. It is characterized by that.

  According to a fourth aspect of the present invention, in the dissolution apparatus according to any one of the first to third aspects, the determination unit is set so that the stirring by the stirring unit is performed for a predetermined time, and after the predetermined time has elapsed. When it is determined that there is any undissolved residue of the dialysis powder drug, the fact that there is an undissolved residue is notified.

  The invention according to claim 5 is the dissolution apparatus according to any one of claims 1 to 4, wherein the stirring is performed on the condition that the determination means determines that there is no undissolved residue of the powder drug for dialysis. The stirring by the means is terminated.

  According to a sixth aspect of the present invention, in the dissolving apparatus according to any one of the first to fifth aspects, the water supply operation by the water supply line or the stirring means is based on the liquid level detected by the liquid level detecting means. An abnormality in the stirring operation can be detected.

A seventh aspect of the present invention is the lysis device according to any one of the first to sixth aspects, wherein the dialysis device is generated in the dissolution tank based on the liquid level detected by the liquid level detecting means. The volume of the stock solution can be calculated.
The invention according to claim 8 is the dissolution apparatus according to any one of claims 1 to 7, wherein when the determination means determines that there is undissolved residual powder medicine for dialysis, the solution by the stirring means Is agitated again.

  According to invention of Claim 1, based on the liquid level detected by the liquid level detection means which can detect the liquid level of the water or solution supplied in the dissolution tank continuously and in real time, and the liquid level detection means And a means for judging whether or not the dialysis powder drug remains undissolved in the solution generated in the dissolution tank, so that the dialysis powder drug dissolves in the dialysis stock solution stirred and generated in the dissolution tank. The presence or absence of the remaining can be accurately determined with a simple configuration.

  According to the invention of claim 2, the judging means compares the theoretical value of the liquid level when the powder drug for dialysis is completely dissolved in water and the actual value of the liquid level detected by the liquid level detecting means. Because it is possible to determine whether or not the dialysis powder drug remains undissolved from the difference between the theoretical value of the liquid level and the measured value, it is possible to more accurately determine whether or not the dialysis powder drug remains undissolved in the dialysis stock solution after preparation. can do.

  According to the invention of claim 3, the judging means can calculate the amount of undissolved amount of the dissolution of the powder drug for dialysis from the difference between the theoretical value and the actually measured value of the liquid level. The degree of the above can be grasped, and the operator can be informed of the stirring time for complete dissolution.

  According to the invention of claim 4, it is set so that the stirring by the stirring means is performed for a predetermined time, and when the determination means determines that there remains undissolved powder of the dialysis drug after the predetermined time has passed, Therefore, it is possible to prevent the undiluted dialysis stock solution from being fed to the dialysis treatment apparatus side.

  According to the fifth aspect of the present invention, the stirring by the stirring means is terminated on the condition that the determination means determines that there is no undissolved dialysis powder drug, so the stirring is terminated when the undissolved residue disappears. The dialysis stock solution can be prepared more efficiently.

  According to the sixth aspect of the present invention, an abnormality in the water supply operation by the water supply line or the stirring operation by the stirring means can be detected based on the liquid level detected by the liquid level detecting means. In addition to functioning as a means for determining the presence or absence of the device, it can function as a means for monitoring an abnormality of the apparatus.

  According to the seventh aspect of the present invention, the volume of the dialysis stock solution generated in the dissolution tank can be calculated based on the liquid level detected by the liquid level detection means. In addition to functioning as a means for determining the presence or absence, it can function as a means for calculating the volume of the dialysis stock solution produced in the dissolution tank.

The top view and front view which show the melt | dissolution apparatus which concerns on embodiment of this invention Schematic diagram showing the internal configuration of the dissolution apparatus Flow chart showing control contents in the dissolution apparatus

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The dissolution apparatus according to the present embodiment dissolves a dialysis powder drug to obtain a dialysis stock solution. As shown in FIGS. 1 and 2, a dissolution tank 2 and an auxiliary dissolution tank that can accommodate a dialysis powder drug 3, the water supply lines L1 and L2 for supplying water for dissolving the dialysis powder drug to each of the dissolution tank 2 and the auxiliary dissolution tank 3, and the liquid in the dissolution tank 2 and the auxiliary dissolution tank 3 are stirred. Mainly composed of agitation means 4 and 5, a liquid level detection means 6, a determination means 7 having a storage means 8 and a calculation means 9, an input means 10, and a display means 11.

  The dissolution tank 2 has a storage space in which a powder drug for dialysis composed of either one of sodium bicarbonate (A agent) or sodium bicarbonate (B agent) can be charged, and a water supply source A A water supply line L1 extending from is connected. The water supply line L1 is provided with a valve V1 composed of an electromagnetic valve or the like, and water can be supplied into the dissolution tank 2 by opening the valve V1. Thus, after supplying a predetermined amount of water from the water supply source A into the dissolution tank 2 and storing it, a predetermined amount of the powdered dialysis drug for the amount of the water is supplied to the dissolution tank 2. By adding and stirring, a dialysis stock solution having a predetermined amount and a predetermined concentration can be obtained.

  The auxiliary dissolution tank 3 has a space where a dialysis powder drug of the same type as the dialysis powder charged in the dissolution tank 2 can be charged, and a water supply line L2 extending from the stirring line L3 of the dissolution tank 2 is connected. Has been. The water supply line L2 is provided with a valve V2 composed of an electromagnetic valve or the like. By opening the valve V2, water can be supplied from the dissolution tank 2 into the auxiliary dissolution tank 3. The auxiliary dissolution tank 3 is a tank having a relatively small capacity compared to the dissolution tank 2, and is connected to the dissolution tank 2 through an overflow line L5.

  Accordingly, the powder drug for dialysis is put in advance in the auxiliary dissolution tank 3, and a sufficient amount of water determined in the dissolution tank 2 is supplied at the time of treatment, and stirring is performed while supplying water from the water supply line L2. The valve V3 disposed in L3 is closed, and the solution is sent to the dissolution tank 2 via the overflow line L5, so that both the dissolution tank 2 and the auxiliary dissolution tank 3 have a predetermined amount and a predetermined amount. Concentrate stock solution for dialysis is produced. First, the dialysis stock solution in the dissolution tank 2 is sent to the dialysis treatment device side (dialysis solution supply device etc.), and when the dissolution tank 2 is empty, the dialysis stock solution in the auxiliary dissolution tank 3 is continued. The liquid can be sent. In addition, while the undiluted solution for dialysis in the auxiliary dissolving tank 3 is being fed, the undiluted solution for dialysis can be generated by the dissolving tank 2 alone by introducing and dissolving the dialysis powder drug in the dissolving tank 2. it can.

  Therefore, by providing the auxiliary dissolution tank 3, before treatment (the night before the treatment, etc.), the dissolution tank 2 is cleaned or disinfected with the powder for dialysis charged in the auxiliary dissolution tank 3. It can function as a reservoir during treatment. Moreover, the powder medicine for dialysis applied to this embodiment is packed in a dissolution bag every predetermined amount, and the operator breaks the dissolution bag, and the powder medicine for dialysis in the dissolution tank 2 or the auxiliary dissolution tank. 3 is to be input.

  The agitation means 4 is for agitating the liquid (solution) accommodated in the dissolution tank 2, and in the present embodiment, comprises a nozzle connected to the tip of the circulation line L3. The circulation line L3 extends from the bottom surface of the dissolution tank 2, and includes a circulation flow path connected to stirring means 4 disposed in the dissolution tank 2, and a pump P1 in the middle of the flow path. Is arranged. Thus, when the pump P1 is driven, the liquid in the dissolution tank 2 can be ejected from the stirring means 4 and circulated, so that the liquid in the dissolution tank 2 can be stirred.

  The stirring means 5 is for stirring the liquid (solution) stored in the auxiliary dissolution tank 3, and in the present embodiment, is composed of a nozzle connected to the tip of the water supply line L2. The water supply line L <b> 2 extends from the stirring line L <b> 3 of the dissolution tank 2, and the tip thereof is connected to the stirring means 5 disposed in the auxiliary dissolution tank 3. Then, when a sufficient amount of water set in the dissolution tank 2 is supplied, and then the valve V2 is opened and the pump P1 is driven, the liquid in the dissolution tank 2 is ejected from the stirring means 5, and the inside of the auxiliary dissolution tank 3 In addition to stirring the dialysis powder drug, the valve V3 disposed in the stirring line L3 is closed, and the solution is also fed to the dissolution tank 2 via the overflow line L5. Stirring and dissolution are performed both in the tank 3.

  In addition, although the stirring means 4 and 5 which concern on this embodiment consist of the nozzle connected to the front-end | tip of the circulation line L3 which consists of a circulation flow path, and the water supply line L2, the dissolution tank 2 and the auxiliary dissolution tank 3 are used. As long as it can stir the solution inside, it may be in another form (for example, an impeller that can be rotationally driven in the dissolution tank 2 and the auxiliary dissolution tank 3). Further, shower means capable of ejecting liquid in a shower shape may be provided on the upper part of the dissolution tank 2 and the auxiliary dissolution tank 3, and the shower means may be connected to the ends of the circulation line L3 and the water supply line L2.

  The liquid level detection means 6 is composed of a sensor disposed in the dissolution tank 2 and can continuously and in real time detect the liquid level of the water or solution supplied into the dissolution tank 2. The liquid level detection means 6 according to the present embodiment includes a displacement part 6a extending in the vertical direction in the accommodation space of the dissolution tank 2, and a displacement part 6a while floating on the liquid level of the liquid accommodated in the dissolution tank 2. The magnetostrictive linear displacement sensor has a floating means 6b that can move up and down along the surface of the liquid. By detecting the position of the floating means 6b relative to the displacement portion 6a continuously and in real time, Can be detected.

  The liquid level detection means 6 may be either a contact type or a non-contact type as long as the liquid level of the water or solution supplied into the dissolution tank 2 can be detected continuously and in real time. In addition to the magnetostrictive linear displacement sensor using the floating means as in the present embodiment, an ultrasonic sensor or the like may be used. In the present embodiment, the liquid level detecting means 6 is disposed only in the dissolution tank 2, but it may be disposed in the auxiliary dissolution tank 3 together with the dissolution tank 2.

  Moreover, the input means 10 and the display means 11 are arrange | positioned at the housing | casing part of the melting apparatus 1 which concerns on this embodiment. The input means 10 is constituted by an operation switch or a touch panel that can be input by an operator. In this embodiment, the input means 10 indicates the amount of the dialysis powder drug introduced into the dissolution tank 2 or the auxiliary dissolution tank 3. It can be entered. The display means 11 is composed of a liquid crystal monitor or the like, and is capable of performing various displays relating to the melting operation.

  Here, the dissolution apparatus 1 according to the present embodiment includes a determination means 7 electrically connected to the liquid level detection means 6, the input means 10, the display means 11, and the like. The determination means 7 is composed of, for example, a microcomputer or the like, and based on the liquid level detected by the liquid level detection means 6, determines whether or not the dialysis powder drug remains undissolved in the solution generated in the dissolution tank 2. It is configured to be able to.

  The determination means 7 according to the present embodiment compares the theoretical value of the liquid level when the powder drug for dialysis is completely dissolved in water and the actual value of the liquid level detected by the liquid level detection means 6, From the difference between the theoretical value of the liquid level and the actually measured value, it can be determined whether or not the powder drug for dialysis has remained undissolved. Specifically, the determination means 7 includes a storage means 8 for storing a theoretical value of the liquid level when the powder drug for dialysis is completely dissolved in water, and a theoretical value of the liquid level stored in the storage means 8. And a calculating means 9 for comparing the measured value of the liquid level detected by the liquid level detecting means 6 (for example, subtraction or ratio of the theoretical value of the liquid level and the measured value of the liquid level). If the theoretical value and the actually measured value of the liquid level are substantially the same, it is determined that there is no undissolved residue (completely dissolved) of the dialysis powder drug in the solution generated in the dissolution tank 2. ing.

  On the other hand, in the present embodiment, the input means 10 inputs the amount of the dialysis powder medicine charged into the dissolution tank 2 (specifically, the number of dissolution bags used). Based on the inputted input value and the liquid level detected by the liquid level detecting means 6, it can be determined whether or not the dialysis powder drug remains undissolved. That is, the judging means 7 grasps the input amount of the dialysis powder drug (the number of dissolving bags × the capacity of one dissolving bag) from the input value (the number of dissolving bags) input by the input means 10 and inputs the input. The value is compared with the amount of water supplied to determine “undissolved”. As a result, the amount of the dialysis powder drug to be charged can be reliably ascertained by the dissolving device, and whether or not the dialysis powder drug remains undissolved can be accurately determined.

  And the judgment means 7 is still in the case where the measured value of the liquid level after the melting operation is different from the theoretical value of the liquid level (specifically, when the measured value of the liquid level is larger than the theoretical value of the liquid level). Judge that there is undissolved residual powder drug for dialysis. In other words, the volume of the dialysis powder drug gradually decreases in the process of dissolving in water, and the volume (volume) in a completely dissolved state is theoretically determined. ) To obtain a theoretical value of the liquid level, which is stored in the storage means 8, and the liquid level in which the actual value of the liquid level detected by the liquid level detection means 6 is stored in the storage means 8. If it is determined whether or not it agrees with the theoretical value, the remaining melt can be determined.

  Furthermore, the calculation means 9 of the determination means 7 according to the present embodiment is configured to be able to calculate the remaining amount of dissolution of the dialysis powder drug from the difference between the theoretical value of the liquid level and the actual measurement value. Further, the storage means 8 stores the relationship between the difference between the theoretical value of the liquid level and the actual measurement value and the amount of the undissolved amount of the powder drug for dialysis, and the amount of undissolved amount is detected from the relationship. May be. Thereby, in addition to the presence or absence of undissolved material, the degree of undissolved material can be grasped, and the operator can be informed of the stirring time for complete dissolution.

  Furthermore, the calculation means 9 of the determination means 7 according to the present embodiment can calculate the volume of the dialysis stock solution generated in the dissolution tank 2 based on the liquid level detected by the liquid level detection means 6. It is configured. By calculating the volume of the dialysis stock solution produced in the dissolution tank 2, for example, it can be determined whether or not the dialysis stock solution is sufficient until the dialysis treatment is completed. Therefore, the liquid level detection means 6 can function as a means for calculating the volume of the dialysis stock solution generated in the dissolution tank 2 in addition to functioning as a means for determining whether there is any undissolved residue. it can.

  Further, the dissolution apparatus 1 according to the present embodiment is set so that the stirring by the stirring means 4 is performed for a predetermined time, and after the predetermined time has elapsed, the determination means 7 determines that there is any undissolved dialysis powder drug. If there is, it will be notified that there is unmelted residue. The notification may be, for example, a notification by sound, a warning sound such as a buzzer, in addition to the display by the display unit 11.

  Further, in the present embodiment, the stirring by the stirring means 4 is terminated on condition that the determination means 7 determines that there is no undissolved dialysis powder drug. This makes it possible to stop stirring when there is no undissolved residue. Even if there is no undissolved residue, the dialysis stock solution can be prepared more efficiently than when it is necessary to stop stirring after a predetermined time. can do.

  Furthermore, in the present embodiment, an abnormality in the water supply operation by the water supply line L1 or the stirring operation by the stirring means 4 can be detected based on the liquid level detected by the liquid level detection means 6. Thereby, in addition to making the liquid level detection means 6 function as a means for determining the presence or absence of undissolved, it can function as a means for monitoring the abnormality of the dissolving apparatus 1. It should be noted that the determination as to whether there is an abnormality in the melting apparatus 1 may be performed by the determination means 7 or may be performed by another configuration.

Next, the control content of the dissolution apparatus 1 according to the present embodiment (production of a dialysis stock solution using the dissolution tank 2 alone) will be described based on the flowchart of FIG.
First, the operator inputs (S1) the amount of the dialysis powder drug to be charged (that is, the number of dissolution bags to be used) by the input means 10 and then opens the valve V1 so that the inside of the dissolution tank 2 is opened. Is supplied with a predetermined amount of water (S2), and the amount of dialysis powder drug input to the input means 10 (dissolution bag) is charged into the dissolution tank 2 (S3).

  Then, in S4, the pump P1 is driven to operate the stirring means 4, and the solution (dialysis stock solution) is prepared by stirring and dissolving the water and the powder drug for dialysis in the dissolution tank 2 for a predetermined time. Thereafter, the liquid level detection means 6 detects the liquid level after the stirring of the water and the powder drug for dialysis (S5), and based on the detected liquid level, dialyzes the solution generated in the dissolution tank 2. The determination means 7 determines whether or not the powder drug for dissolution remains undissolved (S6). If it is determined in S6 that there is no undissolved residual powder drug for dialysis, a series of stirring and dissolving operations are completed.

  On the other hand, if it is determined in S6 that the dialysis powder drug remains undissolved, the process proceeds to S7, and the display means 11 notifies that there is undissolved (or possibility of undissolved). In S8, the operator waits for an input operation. When the input operation is performed, it is determined whether or not the input is an instruction to continue the work (S9). If it is determined in S9 that an instruction to continue the operation is input, the process proceeds to S4, the stirring means 4 is operated again to perform the melting operation, and an instruction to continue the operation is input in S9. If it is determined that the process has been performed, the process proceeds to S10 and the solution in the dissolution tank 2 is discarded.

  According to the above embodiment, based on the liquid level detection means 6 capable of continuously and in real time detecting the liquid level of the water or solution supplied into the dissolution tank 2 and the liquid level detected by the liquid level detection means 6. And a determination means 7 capable of determining whether or not the dialysis powder drug remains undissolved in the solution generated in the dissolution tank 2, for dialysis in the dialysis stock solution agitated and generated in the dissolution tank 2. The presence or absence of undissolved powder drug can be accurately determined with a simple configuration.

  In particular, the determination means 7 according to the present embodiment compares the theoretical value of the liquid level when the powder drug for dialysis is completely dissolved in water and the actual value of the liquid level detected by the liquid level detection means 6. Because it is possible to determine whether or not the dialysis powder drug remains undissolved from the difference between the theoretical value of the liquid level and the measured value, it is possible to more accurately determine whether or not the dialysis powder drug remains undissolved in the dialysis stock solution after preparation. can do. Moreover, according to this embodiment, even if the water in the dissolution tank 2, the ambient temperature, or the like changes, it is possible to more accurately determine whether or not the dialysis powder drug remains undissolved.

  Furthermore, according to the present embodiment, when the stirring by the stirring means 4 is set to be performed for a predetermined time, and after the predetermined time has elapsed, when the determination means 7 determines that there is undissolved powder powder for dialysis, Since it is notified that there is undissolved residue, it is possible to prevent the undiluted undiluted dialysis solution from being sent to the dialysis treatment device (dialyzed fluid supply device or the like). The predetermined time for stirring may be stored in advance or may be input by the input means 10.

  As mentioned above, although this embodiment was described, this invention is not limited to this, Based on the liquid level detected by the liquid level detection means 6, melt | dissolution of the powder medicine for dialysis in the solution produced | generated in the dissolution tank 2 As long as it has a determination means that can determine the presence or absence of the remaining, it is not limited to calculating the difference between the theoretical value of the liquid level and the actual measurement value, but may be determined from other parameters. Further, in this embodiment, the remaining amount of dissolution of the dialysis powder drug is calculated by the calculation means 9, but the calculation is not performed, and only the presence or absence of the undissolved powder of the dialysis powder drug is determined. It is good.

  In the present embodiment, the auxiliary dissolution tank 3 is provided in addition to the dissolution tank 2, but the liquid level detection similar to that of the dissolution tank 2 is also provided in the auxiliary dissolution tank 3 or the auxiliary dissolution tank 3. Means 6 may be provided, and the liquid level detection means 6 may be electrically connected to the determination means 7. Furthermore, it is assumed that the dialysis powder drug can be dissolved in each of the two dissolution tanks to produce a dialysis stock solution, and the solution is alternately sent from these dissolution tanks to the dialysis treatment device side (dialysis solution supply device, etc.). It may be obtained. In the present embodiment, the same type of dialysis powder drug is added to the dissolution tank 2 and the auxiliary dissolution tank 3 for dissolution, but the dissolution tank 2 and the auxiliary dissolution tank 3 can be dissolved independently. If it is a simple piping configuration, different powder drugs for dialysis (agent A and agent B) may be added and dissolved.

  Further, the determination means 7 determines whether or not the powder drug for dialysis is left undissolved in the solution generated in the dissolution tank 2 based on the liquid level detected by the liquid level detection means 6. Based on the liquid level detected by the detection means 6, it is also possible to determine whether or not the amount of the dialysis powder drug introduced into the dissolution tank 2 with respect to the amount of water supplied into the dissolution tank 2 is appropriate. Good. In this case, the determination means 7 uses the theoretical value of the liquid level when the amount of the powdered dialysis drug charged with respect to the amount of water supplied into the dissolution tank 2 is appropriate, and the liquid level detection means 6. Compared with the measured value of the detected liquid level, the difference between the theoretical value of the liquid level and the measured value indicates the amount of the powdered dialysis drug introduced into the dissolving tank relative to the amount of water supplied into the dissolving tank 2. It is preferable to judge whether the amount is appropriate (excess or deficiency). As a result, in addition to causing the liquid level detection means 6 to function as a means for determining whether or not the dialysis powder drug remains undissolved, as a means for determining the suitability of the amount of the dialysis powder drug input. Can function.

  If the dissolution apparatus is equipped with a determination means that can determine the presence or absence of undissolved dialysis powder drug in the solution generated in the dissolution tank based on the liquid level detected by the liquid level detection means, the external shape is The present invention can also be applied to a different one or another function added.

DESCRIPTION OF SYMBOLS 1 Dissolution apparatus 2 Dissolution tank 3 Auxiliary dissolution tank 4 Stirring means 5 Stirring means 6 Liquid level detection means 7 Judgment means 8 Storage means 9 Calculation means 10 Input means 11 Display means L1, L2 Water supply line

Claims (8)

In a dissolution apparatus for dissolving a dialysis powder drug to obtain a dialysis stock solution,
A dissolution tank capable of containing the powder drug for dialysis;
A water supply line for supplying water for dissolving the powder drug for dialysis to the dissolution tank;
A stirring means capable of stirring the solution in the dissolution tank;
Liquid level detection means capable of continuously and in real time detecting the liquid level of water or solution supplied into the dissolution tank;
Based on the liquid level detected by the liquid level detection means, a determination means capable of determining whether or not the dialysis powder drug is undissolved in the solution generated in the dissolution tank;
A melting apparatus comprising:   The determination means compares the theoretical value of the liquid level when the powder drug for dialysis is completely dissolved in water and the actual value of the liquid level detected by the liquid level detection means, and calculates the theoretical value of the liquid level. The dissolution apparatus according to claim 1, wherein whether or not the dialysis powder drug remains undissolved can be determined from a difference between the measured value and the actual measurement value.   3. The dissolution apparatus according to claim 2, wherein the determination means can calculate an undissolved amount of dissolution of the powder drug for dialysis from a difference between a theoretical value and an actual measurement value of the liquid level.   It is set so that stirring by the stirring means is performed for a predetermined time, and when the determination means determines that there is undissolved residue of the dialysis powder drug after the predetermined time has elapsed, it notifies that there is undissolved residue. The melting apparatus according to any one of claims 1 to 3.   The dissolution according to any one of claims 1 to 4, wherein the stirring by the stirring means is terminated on condition that the determination means determines that there is no undissolved residue of the dialysis powder drug. apparatus.   6. The abnormality of the water supply operation by the water supply line or the stirring operation by the stirring unit can be detected based on the liquid level detected by the liquid level detection unit. Melting equipment.   The volume of the stock solution for dialysis generated in the dissolution tank can be calculated based on the liquid level detected by the liquid level detection means, according to any one of claims 1 to 6. Melting device. The dissolution according to any one of claims 1 to 7, wherein when the determination means determines that there remains undissolved powder powder for dialysis, the stirring of the solution by the stirring means is performed again. apparatus.

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