JP4979069B2 - Dissolving device and method for measuring remaining amount in storage tank - Google Patents

Description

  The present invention relates to a dissolution apparatus for dissolving a dialysis powder drug at a predetermined concentration to obtain a dialysis stock solution and a method for measuring the remaining amount in the storage tank.

  Dialysis fluids used for the treatment of patients with renal failure in hospitals are generally divided into bicarbonate and acetic acid. Of these, bicarbonate-based dialysate does not contain sodium bicarbonate (hereinafter referred to as “bicarbonate”). It is prepared by mixing water with two types of drugs, called A agent and sodium bicarbonate (hereinafter referred to as B agent). In recent years, from the viewpoint of improving transportability, attempts have been made to dissolve these A agent and B agent powdered powder (hereinafter referred to as dialysis powder drug) before dialysis. With regard to B agent), the concentration tends to decrease over time, and it was difficult to prepare the next day after dialysis.

  For this reason, dissolution work is required for each dialysis, and various types of dissolution apparatuses for dissolution have been proposed. For example, as shown in FIG. 5, a predetermined amount of powder drug for dialysis and water were added, and dissolution powder 101 obtained by dissolving and stirring the powder drug for dialysis to obtain a stock solution for dialysis was obtained in the dissolution tank 101. A storage tank 102 that temporarily stores a dialysis stock solution, and a stock solution supply line L2 that supplies the dialysis stock solution stored in the storage tank 102 to a plurality of dialysis apparatuses for performing dialysis treatment on a patient. A melting device has been proposed.

  The dissolution tank 101 communicates with a container B containing a predetermined amount of powdered drug for dialysis via a circulation line L3. After the water supply valve V3 is opened and water is supplied from the water supply line L7, the circulation pump P is driven. Thus, it is possible to circulate water and the powder drug for dialysis between the dissolution tank 101 and the container B, thereby stirring and dissolving. And it is comprised so that the drive of the circulation pump P may be stopped after predetermined time progress. If it is determined that the concentration of the dialysis stock solution detected by the concentration cell 105 is abnormal, a drain operation is performed.

  Thus, the dialysis stock solution having a predetermined concentration is accommodated in the dissolution tank 101, and by opening the transfer valve V1, the dialysis stock solution falls into the storage tank 102, and the dialysis stock solution is temporarily stored. It can be accommodated. Thus, the dialysis stock solution accommodated in the storage tank 102 can be supplied to the dialysis machine side via the stock solution supply line L2. Reference numerals L6 and V2 in the figure indicate a discharge line for discharging the dialysis stock solution in the dissolution tank 101 while bypassing the storage tank 102, and a valve for opening and closing the flow path.

  On the other hand, the remaining amount of the dialysis stock solution in the storage tank 102 can be detected by the level sensor 103, and the operator determines whether it is necessary to prepare an additional dialysis stock solution based on the remaining amount. can do. The level sensor 103 is disposed on the bottom surface of the storage tank 102 and is configured to detect the liquid level (ie, remaining amount) of the stored dialysis stock solution by detecting the fluid pressure in the storage tank 102. ing.

  Incidentally, vent lines L4 and L5 are extended from the upper part of the dissolution tank 101 and the storage tank 102, respectively. These aeration lines L4 and L5 are merged at a midway junction A and are opened to the atmosphere via an air filter 104, and can be ventilated by communicating the dissolution tank 101 and the storage tank 102 with the outside. It is said. That is, when water is supplied into the dissolution tank 101, when the dialysis stock solution is circulated, or when the dialysis stock solution is discharged from the discharge line L6, the inside of the dissolution tank 101 and the storage tank 102 is passed through the aeration lines L4 and L5. By allowing the air to enter and exit the water, water supply, circulation, and the like are performed smoothly. In addition, since this prior art does not relate to the literature known invention, there is no prior art document information to be described.

  However, in the conventional melting apparatus, the melting tank 101 and the storage tank 102 are respectively extended from the melting tank 101 and the storage tank 102. Since the storage tank 102 is provided with ventilation lines L4 and L5 communicating with the outside, when supplying water into the dissolution tank 101, when circulating the dialysis stock solution, or when discharging the dialysis stock solution from the discharge line L6, There was a problem that the detection value detected by the level sensor 103 fluctuated irrespective of the remaining amount of the dialysis stock solution.

  That is, since the aeration lines L4 and L5 merge at the junction A and share the air filter 104, when supplying water into the dissolution tank 101, when circulating the dialysis stock solution, or when discharging the dialysis stock solution L6 During the operation of the dissolution tank 101, such as when discharged from the tank, the pressure fluctuation on the dissolution tank 101 side affects the storage tank 102 side, and the fluid pressure to be detected by the level sensor 103 is independent of the remaining amount of the dialysis stock solution. The remaining amount of the dialysis stock solution cannot be accurately detected.

  Note that the above problem does not occur if a vent line that communicates with the outside independently from the dissolution tank 101 and the storage tank 102 is provided, but in that case, an air filter must be provided for each independent vent line. There is a problem that manufacturing cost and maintenance cost increase. In particular, since the air filter to be disposed in the ventilation line is generally expensive, the cost deterioration becomes remarkable.

  The present invention has been made in view of such circumstances, and can accurately detect the remaining amount of the dialysis stock solution in the storage tank while maintaining the common use of the air filter in the aeration line of the dissolution tank and the storage tank. It is providing the melt | dissolution apparatus and the residual amount measuring method in the storage tank.

The invention according to claim 1 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A storage tank for temporarily storing the stock solution, a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialysis apparatuses for performing dialysis treatment on the patient, and the dissolution tank and the storage tank, respectively. A melting device that includes a vent line that extends and is opened to the atmosphere through an air filter while being joined in the middle, and that communicates the dissolution tank and the storage tank with the outside, wherein the liquid in the storage tank Fluid pressure detecting means for detecting pressure continuously and in real time, and calculation capable of calculating the remaining amount of the dialysis stock solution in the storage tank based on the fluid pressure detected continuously and in real time by the fluid pressure detecting means Means and movement of the dissolution tank Controls the said liquid during operation of the dissolving tank the detected value becomes unstable in pressure detecting means, characterized in that a control means for stopping the operation by the operation means.

  The invention described in claim 2 is a dissolution apparatus according to claim 1, which is substantially closed to include a water supply line for supplying water into the dissolution tank, and a container in which a predetermined amount of the dissolution tank and dialysis powder drug is contained. A circulation line that is formed in a shape and dissolves while stirring by circulating the water supplied from the water supply line and the powder drug for dialysis in the container to obtain a predetermined concentration of dialysis stock solution, A discharge line for discharging the dialysis stock solution while bypassing the storage tank, and the control means controls the water supply operation by the water supply line, the circulation operation by the circulation line, and the discharge operation by the discharge line, When the water supply operation, the circulation operation, and the discharge operation are performed, the calculation by the calculation means is not performed.

  According to a third aspect of the present invention, in the dissolution apparatus according to the first or second aspect, the calculating means can calculate the reduction ratio based on the calculated remaining amount of the dialysate stock solution, and the calculating means A determination means for estimating the time until the dialysis stock solution in the storage tank is emptied from the rate of decrease in the dialysis stock solution calculated in step 1, and determining whether or not the dialysis stock solution to be supplied is insufficient. It is characterized by.

  According to a fourth aspect of the present invention, in the dissolution apparatus according to any one of the first to third aspects, the control is performed on the condition that the dialysis stock solution to be supplied by the determination means is determined to be insufficient. The means is characterized in that an operation for dissolving the additional dialysis solution by the dissolution tank is performed.

The invention according to claim 5 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A storage tank for temporarily storing the stock solution, a stock solution supply line for supplying the dialysis stock solution stored in the storage tank to a plurality of dialysis apparatuses for performing dialysis treatment on the patient, and the dissolution tank and the storage tank, respectively. A vent line that extends and is opened to the atmosphere through an air filter while converging in the middle, communicating the dissolution tank and storage tank with the outside, and the fluid pressure in the storage tank is detected continuously and in real time. A method for measuring a remaining amount in a storage tank of a dissolution apparatus comprising a hydraulic pressure detection means for performing dialysis stock solution in the storage tank based on a hydraulic pressure detected continuously and in real time by the hydraulic pressure detection means That can calculate the remaining amount of And it has a process, the liquid during operation of the dissolving tank the detected value becomes unstable in pressure detecting means, characterized in that stopping operation by the arithmetic process.

  The invention according to claim 6 is the method for measuring the remaining amount in the storage tank of the dissolution apparatus according to claim 5, wherein the dissolution apparatus comprises a water supply line for supplying water into the dissolution tank, the dissolution tank and the dialysis powder. It is formed in a substantially closed shape including a container in which a predetermined amount of drug is contained, and the water supplied from the water supply line and the powder drug for dialysis in the container are circulated and dissolved while stirring to dialyze at a predetermined concentration. And a discharge line for discharging the dialysis stock solution in the dissolution tank while bypassing the storage tank, a water supply operation by the water supply line, a circulation operation by the circulation line, and the discharge When the discharge operation by the line is performed, the calculation by the calculation step is not performed.

  The invention according to claim 7 is the method for measuring the remaining amount in the storage tank of the dissolution apparatus according to claim 5 or claim 6, wherein the calculating step calculates the decreasing rate based on the calculated remaining amount of the dialysate stock solution. It is possible to calculate the time until the dialysis stock solution in the storage tank becomes empty from the decrease rate of the dialysis stock solution calculated in the calculation step, and whether or not the dialysis stock solution to be supplied is insufficient. It has the determination process to determine, It is characterized by the above-mentioned.

  According to an eighth aspect of the present invention, in the method for measuring the remaining amount in the storage tank of the dissolution apparatus according to any one of the fifth to seventh aspects, it is determined that the dialysis stock solution to be supplied by the determination step is insufficient. On the condition that, the dissolution operation of the additional dialysis solution by the dissolution tank is performed.

According to the invention of claim 1 or claim 5, during the operation of the dissolution tank in which the detection value of the fluid pressure detection means becomes unstable, the calculation of the remaining amount of the dialysis stock solution in the storage tank is stopped, whereby the dissolution tank The calculation can be performed only when the pressure fluctuation on the side does not affect the storage tank side, so that the dialysis stock solution in the storage tank can be used while maintaining the common use of the air filter in the aeration line of the dissolution tank and the storage tank. The remaining amount can be accurately detected.

  According to the invention of claim 2 or claim 6, when the water supply operation by the water supply line, the circulation operation by the circulation line, and the discharge operation by the discharge line are performed, the calculation of the remaining amount of the dialysis stock solution in the storage tank is performed. Since it is not performed, the judgment that the calculation should be performed can be made clearer, and the remaining amount of the dialysis stock solution in the storage tank can be determined while maintaining the common use of the air filter in the aeration line of the dissolution tank and the storage tank. It can be detected accurately.

  According to the invention of claim 3 or claim 7, the reduction ratio can be calculated based on the calculated remaining amount of dialysate stock solution, and the dialysis solution in the storage tank can be calculated from the calculated decrease ratio of the dialysate stock solution. Estimates the time until the stock solution is empty, and determines whether or not there is a shortage of dialysis stock solution to be supplied, so that it is possible to automatically and accurately determine whether or not to create a dialysis stock solution. In addition, it is possible to avoid the problem that a large amount of the dialysis solution is left at the end of the dialysis treatment while avoiding a situation where the dialysis solution is insufficient.

  According to the invention of claim 4 or claim 8, since it is determined that the dialysis stock solution to be supplied is insufficient, the additional dialysis stock solution is dissolved in the dissolution tank. In addition to determining whether or not additional production should be performed, an additional dissolution operation of the dialysis stock solution can be automatically performed.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The dissolution apparatus according to the present embodiment is for obtaining a dialysis stock solution by dissolving a powder drug for dialysis at a predetermined concentration, and is installed in a machine room together with the dialysate supply apparatus 10 as shown in FIG. It is. In a dialysis room isolated from the machine room, a plurality of dialysis apparatuses 12 (dialysis monitoring apparatuses) and a central monitoring apparatus 11 for performing dialysis treatment on a patient are installed.

  The dialysis stock solution (concentrated solutions of agent A and agent B) generated by the dissolving device 9 reaches the dialysate supply device 10 via the stock solution supply line L2 (L2a and L2b in FIG. 3), and is predetermined there. A dialysate having a concentration is prepared, and the dialysate is supplied to each dialyzer 12 (dialysis monitoring device) via the dialysate supply lines La to Lc. Although not shown, a dissolution apparatus having the same configuration as that shown in the figure is separately provided, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to produce each dialysis stock solution. It has come to be able to do. In addition, each dialysis device 12 and the central monitoring device 11 are electrically connected by wires D1 to D3, respectively, so that treatment information and the like can be transmitted and received.

  As shown in FIG. 2, the dissolution apparatus 9 includes a dissolution tank 1 having a predetermined amount of storage space, a storage tank 2 having a predetermined amount of storage space and disposed below the dissolution tank 1, and the storage tank 2. Level sensor 3 (hydraulic pressure detection means), calculation means 6, determination means 7, control means 8, input means 15, transfer line L1, stock solution supply line L2, circulation line L3 disposed on the lower surface of These are mainly composed of ventilation lines L4 and L5, a discharge line L6, and a water supply line L7.

  The dissolution tank 1 is used for supplying a predetermined amount of powder drug for dialysis and water, and dissolving and stirring the powder drug for dialysis to obtain a dialysis stock solution. A float switch SH is provided in a part of the internal storage space. (For detecting the upper limit) and SL (for detecting the lower limit) and communicating with the water supply line L7 and the circulation line L3. The dissolution tank 1 and the storage tank 2 are provided side by side, and both are connected by a transfer line L1 to which a transfer valve V1 is connected. Thereby, if the transfer valve V1 is opened, the dialysis stock solution in the dissolution tank 1 is fed into the storage tank 2 by gravity.

  The water supply line L7 is for supplying water into the dissolution tank 1, and the base end side is connected to a water supply source (not shown), and a water supply valve V3 is disposed in the middle. The circulation line L3 is formed in a substantially closed shape including the dissolution tank 1 and the container B containing a predetermined amount of the dialysis powder medicine, and circulates the water supplied from the water supply line L7 and the dialysis powder medicine in the container B. To obtain a stock solution for dialysis having a predetermined concentration.

That is, the circulation line L3 connects the middle of the transfer line L1 and the upper part of the dissolution tank 1 to form a circulation system line, and the container B in which the powder drug for dialysis is incorporated can be connected to the circulation line L3. If the circulation pump P is driven with the transfer valve V1 closed, the water in the dissolution tank 1 returns to the dissolution tank 1 through the circulation line L3 and the bottle B and circulates. Yes. The bottle B is configured to be automatically replaced from an empty one to one containing a new dialysis powder drug when additional dissolution is required.

  In the course of the circulation, the dialysis powder drug in the container B is dissolved and stirred in water to obtain a dialysis stock solution having a uniform concentration. In the middle of the circulation line L3, a concentration cell 5 is connected so that the concentration of the circulating dialysis stock solution can be detected. In addition, a discharge line L6 for discharging the dialysis stock solution in the dissolution tank 1 while bypassing the storage tank 2 is extended from the middle of the circulation line L3. If the waste liquid valve V2 is opened, a predetermined concentration is obtained. The dialysis stock solution that has not become can be drained.

The storage tank 2 is used to transfer the dialysis stock solution obtained in the dissolution tank 1 and temporarily store the dialysis stock solution, and a stock solution supply line L2 extends from the bottom surface thereof. The stock solution supply line L <b> 2 is for supplying the stock solution for dialysis accommodated in the storage tank 2 to the plurality of dialyzer 12 sides via the dialysate supply device 10. Specifically, the dialysis stock solution is sequentially supplied to the dialysis fluid supply device 10 (a plurality of dialysis devices 12 side), which will be described later, via the stock solution supply line L2, and the dialysate having a predetermined concentration is obtained. The dialysis machine 12 is supplied.

  The aeration lines L4 and L5 are respectively extended from the upper part of the dissolution tank 1 and the upper part of the storage tank 2, and are opened to the atmosphere through the air filter 4 while joining at a confluence point A in the middle thereof. The storage tank 2 is communicated with the outside. As a result, when supplying water into the dissolution tank 1, circulating the dialysis stock solution, or discharging the dialysis stock solution from the discharge line L6, the dissolution tank 1 and the storage tank 2 via the vent lines L4 and L5. Air can enter and exit from the inside, and water supply, circulation, and the like are performed smoothly.

  In addition, since the ventilation lines L4 and L5 merge at the junction A and share the air filter 104, the manufacturing cost is lower than that in which each of the ventilation lines L4 and L5 is provided as an independent ventilation line. In addition, maintenance costs can be reduced. In particular, since the air filter to be disposed in the ventilation line is generally expensive, the cost reduction effect is remarkable.

  On the other hand, a level sensor 3 (hydraulic pressure detecting means) composed of a pressure gauge or the like is disposed on the lower surface of the storage tank 2, and the level sensor 3 continuously determines the remaining amount of the dialysis stock solution in the storage tank 2. It is configured so that it can be detected in real time. That is, the pressure gauge as the level sensor 3 can detect the fluid pressure of the dialysis stock solution in the storage tank 2 over time in terms of the pressure applied to the bottom surface of the storage tank 2.

The level sensor 3 is electrically connected to the calculation means 6. The calculating means 6 can calculate the remaining amount of the dialysis stock solution in the storage tank 2 based on the fluid pressure detected continuously and in real time by the level sensor 3 , and the calculated remaining dialysis solution stock solution. The reduction ratio can be calculated based on the quantity. That is, by continuously and in real time detecting the fluid pressure of the dialysis stock solution in the storage tank 2, the change in the fluid level (decrease in the remaining amount) is grasped, and the rate of decrease in the fluid level (decrease rate of the dialysis stock solution). ) Can be obtained, and the consumption rate of the stock solution for dialysis can be recognized based on the decreasing rate.

  The calculation unit 6 is electrically connected to the determination unit 7. This determination means 7 calculates the time until the dialysis stock solution in the storage tank 2 becomes empty (the remaining liquid is substantially 0) from the rate of reduction of the dialysis stock solution (the reduction rate of the liquid level) calculated by the calculation means 6. And determining whether or not the dialysis stock solution to be supplied is insufficient. Moreover, the input means 15 is electrically connected to the determination means 7, The time when all the dialysis treatment by the dialysis apparatus 12 is complete | finished by this input means 15 (The scheduled time when the dialysis treatment of all the patients of the day is complete | finished) It is comprised so that it can input.

  Thus, the determination means 7 compares the estimated time (insufficient time) when the stock solution for dialysis in the storage tank 2 is emptied with the time (dialysis end time) when all the dialysis treatments by the dialyzer 12 are completed, If it is determined whether or not the time at which the time has elapsed has passed the dialysis end time, it can be determined whether or not the dialysis stock solution is insufficient. Specifically, if the time after the elapse of the shortage time does not exceed the dialysis end time, the additional dialysis stock solution is unnecessary. To be judged.

  The input means 15 may be configured so that other data such as the number of patients on the day can be input, and the determination means 7 determines whether or not the dialysis stock solution is insufficient with reference to the input data. It may be. Further, if the calculation means 6, the determination means 7 and the input means 15 are provided in the central monitoring device 11, the input by the input means 15 etc. even if a medical worker such as a dialysis engineer who is usually in the dialysis room does not go to the machine room. Is possible.

  Further, the determination means 7 is electrically connected to the control means 8 so that the operation of the dissolution tank 1 can be controlled by the control means 8. Specifically, the control means 8 is electrically connected to the transfer valve V1 of the transfer line L1, the waste liquid valve V2 of the discharge line L6, the circulation pump P of the circulation line L3, the water supply valve V3 of the water supply line L7, and the concentration cell 5. Connected and configured to control the water supply operation by the water supply line L7, the circulation operation by the circulation line L3, and the discharge operation by the discharge line L6 in the dissolution tank 1 by controlling these components or receiving detection values. Has been.

  Here, the control unit 8 according to the present embodiment is configured to determine whether or not to perform the calculation by the calculation unit 6 based on the operation state of the dissolution tank 1 as described above. That is, the control means 8 does not perform the calculation by the calculation means 6 when the water supply operation by the water supply line L7, the circulation operation by the circulation line L3, and the discharge operation by the discharge line L6 are performed in the dissolution tank 1. The means 6 can be instructed.

Accordingly, the dissolving tank upon supply of water to the 1, when the circulation of a dialysis concentrate, or dissolver detected value of the level sensor 3, such as time of ejection will be unstable and Tsu Do from discharge line L6 of dialysis stock solution 1 During the operation, the calculation by the calculation means 6 is stopped, and based on the erroneous detection of the level sensor 3, it is determined whether or not the remaining amount of dialysis stock solution, the decreasing rate, and the dialysis stock solution to be supplied are insufficient. Can be avoided.

  That is, when the dissolution tank 1 is in operation, such as when water is supplied into the dissolution tank 1, air flows in and out through the ventilation lines L4 and L5 as described above. The pressure fluctuation on the dissolution tank 1 side affects the storage tank 2 side, and the fluid pressure to be detected by the level sensor 3 fluctuates regardless of the remaining amount of the dialysis stock solution. Although it is expected that the remaining amount cannot be accurately detected and the remaining amount cannot be accurately calculated, according to the present embodiment, it is possible to eliminate the calculation at a time when there is a high possibility of erroneous detection. Thereby, it is possible to make a reliable determination of the remaining amount of dialysis stock solution, the reduction rate, and whether or not the dialysis stock solution to be supplied is insufficient.

However, at the time of supplying water into the dissolution tank 1, circulating the dialysis stock solution, or discharging the dialysis stock solution from the discharge line L6, and also when transferring the dialysis stock solution from the dissolution tank 1 to the storage tank 2, of course, the detection value of the level sensor 3 will be unstable and Tsu Do, and also stops the operation by the arithmetic means 6 during such transport. As a result, even when the dialysis stock solution is transferred, it is determined based on the false detection of the level sensor 3 whether or not the remaining amount of dialysis stock solution, the decreasing rate, and the dialysis stock solution to be supplied are insufficient. Can be avoided.

  As shown in FIG. 3, the dialysate supply device 10 is connected to a water supply line Lw in which a water metering means 13 for measuring the amount of water flowing and the metering pump Pa (piston pump) flows. In addition, a stock solution line L2a for flowing the dialysis stock solution obtained by dissolving the A agent and a metering pump Pb (piston pump) and a stock solution line for flowing the dialysis stock solution obtained by dissolving the B agent are connected. It mainly has L2b, the dialysate storage tank 14, and the liquid feeding pump P2. The stock solution lines L2a and L2b communicate with the stock solution supply line L2 in FIG. Further, a concentration measurement unit for measuring the concentration of the dialysate prepared in FIG. 3 and a heating unit for heating the dialysate are omitted.

  After the water in the water supply line Lw passes through the water metering means 13, the dialysis fluid from the stock solution lines L2a and L2b is mixed to prepare a dialysis fluid having a predetermined concentration, and then the dialysis fluid is placed in the dialysis fluid storage tank 14. Will be reached. The dialysate storage tank 14 is provided with a float switch SH and a float switch SL, and it is possible to detect that the liquid level of the dialysate in the dialysate storage tank 14 has reached the upper limit or the lower limit. Has been. However, the dialysate passes through the dialysate storage tank 14 so that the gas generated from the dialysate can be separated and removed. The dialysate from which the gas is separated and removed is driven by the liquid feed pump P2. Is supplied to each dialysis machine 12 via the dialysate supply lines La to Lc.

  However, the dialysis treatment is given to the patient by the dialysate supplied to each dialysis machine 12. Further, data related to dialysis treatment (treatment conditions, treatment time, etc.) is transmitted and received between each dialysis device 12 and the central monitoring device 11 so that optimum and safe treatment is performed.

Next, the operation of the melting apparatus according to this embodiment will be described.
First, the time (dialysis end time) at which all dialysis treatment by the dialysis device 12 is completed is input in advance by the input means 15. The circulation line L3 is connected to a container B containing a predetermined amount of the dialysis powder drug, and a substantially closed line including the dissolution tank 1 and the container B is formed. Then, after opening the water supply valve V3 and supplying water into the dissolution tank 1 until the float switch SH detects the liquid level, the water supply valve V3 is closed to stop the water supply, and the circulation pump P is driven. .

  Thereby, the water in the dissolution tank 1 circulates in the circulation line L3 and the bottle B, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis having a uniform concentration. And the density | concentration of the obtained undiluted | stock solution for dialysis is detected with the density | concentration cell 5, and if it is a predetermined density | concentration, while being transferred to the storage tank 2, if it is not a predetermined density | concentration, the waste liquid valve V2 will be open | released and the said dialysis The stock solution is discarded.

  When the dialysis stock solution has a predetermined concentration, the dialysis stock solution in the dissolution tank 1 is dropped and transferred to the storage tank 2 through the transfer line L1 by opening the transfer valve V1. When dialysis treatment is started, the dialysis solution supply apparatus 10 is supplied with the dialysis solution supply device 10 via the solution supply line L2, where a dialysis solution having a predetermined concentration is prepared. The dialysis treatment is performed on the patient by being supplied to each dialysis machine 12. A series of operations of the dissolution tank 1 such as the water supply operation by the water supply line L7, the circulation operation by the circulation line L3, and the discharge operation by the discharge line L6 as described above are controlled by the control means 8.

In the process of supplying the stock solution for dialysis to the dialyzer 12 side by the dissolving device 9 as described above, the remaining amount of the stock solution for dialysis in the storage tank 2 decreases according to the dialysate consumed in the dialyzer 12. Therefore, the fluid pressure of the stock solution for dialysis in the storage tank 2 is detected continuously and in real time by the level sensor 3 (a fluid pressure detecting step). Then, based on the fluid pressure detected continuously and in real time by the level sensor 3, the calculation means 6 calculates the remaining amount (liquid level) of the dialysate, and based on the calculated remaining amount, it is used for dialysis. Calculation of the reduction rate (consumption rate) of the stock solution is performed (calculation step).

  The reduction rate obtained in the calculation step is transmitted to the determination means 7, and the time until the dialysis stock solution in the storage tank 2 becomes empty is calculated and estimated from the reduction rate, and the estimated time and input are input. The dialysis end time input by means 15 is compared to determine whether or not the dialysis stock solution to be supplied is insufficient (determination step). In this embodiment, for example, the time required for obtaining the additional dialysis solution is measured in advance, and the dissolving operation is performed until just before the required time. Wait and then let the melting work take place.

  When it is determined in the determination step that the dialysis stock solution is insufficient, a signal based on the determination is transmitted to the control means 8, and the dialysis stock solution production operation control by the dissolution tank 1 as described above is performed. Obtain a dialysis stock solution. However, as described above, the signal is transmitted until the time required for obtaining an additional dialysis solution, and then transmitted.

  In addition, as the dialysis treatment approaches, the number of patients on whom dialysis treatment is performed decreases sequentially, so that the rate of decrease in the dialysis stock solution also decreases. Therefore, it is preferable that the determination means 7 determine whether or not the addition is necessary at a later stage (final stage) in which the dialysis treatment is performed. That is, the determination by the determination unit 7 is not performed until the predetermined time elapses after the preparation of the dialysis stock solution, and it may be determined whether or not additional necessity is required when the dialysis end time is reached.

  Here, in the control means 8 of this embodiment, control as shown in the flowchart of FIG. 4 is performed. That is, it is determined whether or not the dissolution tank 1 is in the water supply (when water is supplied into the dissolution tank 1) (S1). If not, the process proceeds to S4, where the calculation by the calculation means 6 is performed and the process ends. In the case of water supply, the process proceeds to S2. In S2, it is determined whether or not the dissolution tank 1 is in circulation (when the dialysis undiluted solution is being circulated). If not, the process proceeds to S4, where calculation by the calculation means 6 is performed and the process ends. If so, go to S3. In S3, it is determined whether or not the dissolution tank 1 is in waste liquid (when discharging the dialysis stock solution from the discharge line L6). If not in waste liquid, the process proceeds to S4 and calculation is performed by the calculation means and the process is terminated. If it is in the waste liquid, the process is terminated.

That is, the dissolving tank upon supply of water to the 1, when the circulation of a dialysis concentrate, or the level sensor 3, such as when discharged from the discharge line L6 of dialysis concentrate detection value of the dissolution tank 1 thus unstable and Tsu Do At the time of operation, the calculation by the calculation means 6 is stopped (that is, the calculation by the calculation means 6 is not performed), and based on the false detection of the level sensor 3, the remaining amount of dialysis solution, the decreasing rate, and This avoids the determination of whether or not the stock solution is insufficient.

In other words, dissolving tank upon supply of water to the 1, when the circulation of a dialysis concentrate, or dissolver detected value of the level sensor 3, such as time of ejection will be unstable and Tsu Do from discharge line L6 of dialysis stock solution 1 Only when the operation is performed, the calculation means 6 performs the calculation, so that the remaining amount of the dialysis stock solution, the reduction rate, and whether or not the dialysis stock solution to be supplied is insufficient are determined. It can be made.

  According to this embodiment, based on the decreasing rate of the dialysis stock solution, the time until the dialysis stock solution in the storage tank 2 becomes empty is calculated and estimated, and whether or not the dialysis stock solution to be supplied is insufficient. Therefore, it is possible to automatically and accurately determine whether or not the dialysis stock solution should be additionally generated, and to avoid a situation where the dialysis stock solution is insufficient, at the end of dialysis treatment, The problem that the stock solution remains can be avoided. In addition, since it is determined that there is insufficient dialysis stock solution to be supplied, the dissolution tank 1 performs the operation of dissolving the additional dialysis stock solution. In addition, an additional dissolving operation of the dialysis stock solution can be performed automatically.

Further, by determining whether or not the remaining amount of the dialysis stock solution in the storage tank 2 is calculated based on the operation status of the dissolution tank 1, pressure fluctuation on the dissolution tank 1 side does not affect the storage tank 2 side. only when, it is possible to perform the operation, while maintaining a common air filter 4 in vent line L4, L 5 of the dissolution tank 1 and tank 2, the remaining amount of dialysis concentrate in the reservoir 2 accurate Can be detected.

  Furthermore, when the water supply operation by the water supply line L7, the circulation operation by the circulation line L3, and the discharge operation by the discharge line L6 are performed, the remaining amount of the dialysis stock solution in the storage tank 2 is not calculated. In addition, the remaining amount of the dialysis stock solution in the storage tank 2 can be determined while maintaining the common use of the air filter 4 in the aeration lines L4 and L5 of the dissolution tank 1 and the storage tank 2. Can be accurately detected.

  Since the bottle B is configured to be automatically replaced from an empty one with a new powder medicine for dialysis when additional dissolution is required, the determination means 7 or the determination step With the condition that it is determined that the dialysis stock solution to be supplied is insufficient, a predetermined amount of dialysis powder drug and water can be automatically added to the dissolution tank 1 to obtain an additional dialysis stock solution. The burden on medical personnel such as engineers can be reduced and workability can be further improved. Further, the determination means 7 or the determination step compares the estimated time when the dialysis stock solution in the storage tank 2 is emptied with the time when all the dialysis treatments by the dialysis device 12 are completed, and whether or not the dialysis stock solution is insufficient. Therefore, it is possible to automatically determine whether or not to additionally produce a dialysis stock solution with higher accuracy.

  As mentioned above, although this embodiment was described, this invention is not limited to these, For example, a personal dialysis device (Equipped with a means for producing a dialysis fluid such as a dialysis fluid supply device for each dialysis device) in a dialysis chamber. It may be applied to the one provided. Even in this case, the remaining amount of the dialysis stock solution in the storage tank 2 is detected continuously and in real time, and the reduction rate of the dialysis stock solution is calculated based on the remaining amount, and from the reduction rate, The time until the dialysis stock solution becomes empty can be estimated, and it can be determined whether or not the dialysis stock solution to be supplied is insufficient.

  Moreover, in this embodiment, the calculating means 6 is based on the hydraulic pressure which the level sensor 3 as a hydraulic pressure detection means detected, the residual amount of the dialysis stock solution in the storage tank 2, and the dialysis stock solution based on the residual amount However, the present invention may be applied to one that detects only the remaining amount of the dialysis stock solution. That is, the remaining amount of the dialysis stock solution in the storage tank 2 based on the detection value of the level sensor 3 only when the water supply operation by the water supply line L7, the circulation operation by the circulation line L3, and the discharge operation by the discharge line L6 are not performed. Can be obtained accurately. Therefore, the present invention can also be applied to a dissolution apparatus for determining the shortage of the dialysis stock solution to be supplied by the operator only from the obtained remaining amount of the dialysis stock solution or a method for measuring the remaining amount in the storage tank 2.

Other functions can be used as long as the dissolving device stops the calculation of the remaining amount of the dialysis stock solution in the storage tank during the operation of the dissolution tank in which the detection value of the hydraulic pressure detection means becomes unstable. The present invention can be applied to a configuration in which is added.

The schematic diagram which shows the connection state of the melt | dissolution apparatus and other component in embodiment of this invention Schematic diagram showing the configuration of the dissolution apparatus The schematic diagram which shows the structure of the dialysate supply apparatus in embodiment of this invention. The flowchart which shows the control content of the control means in embodiment of this invention Schematic diagram showing the structure of a conventional melting device

Explanation of symbols

1 Dissolution tank 2 Storage tank 3 Level sensor (liquid level detection means)
DESCRIPTION OF SYMBOLS 4 Air filter 5 Concentration cell 6 Calculation means 7 Judgment means 8 Control means 9 Dissolution apparatus 10 Dialysate supply apparatus 11 Central monitoring apparatus 12 Dialysis apparatus (dialysis monitoring apparatus)
13 Water metering means 14 Dialysate storage tank 15 Input means L1 Transfer line L2 (L2a, L2b) Stock solution supply line L3 Circulation line L4, L5 Aeration line L6 Discharge line L7 Water supply line V1 Transfer valve V2 Waste liquid valve V3 Water supply valve P Circulation pump

Claims (8)

A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying the stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
A vent line that extends from the dissolution tank and the storage tank and is opened to the atmosphere via an air filter while being merged in the middle, and the dissolution tank and the storage tank communicated with the outside.
A melting apparatus comprising:
Hydraulic pressure detection means for continuously and in real time detecting the hydraulic pressure in the storage tank;
Calculation means capable of calculating the remaining amount of the dialysis stock solution in the storage tank based on the fluid pressure detected continuously and in real time by the fluid pressure detection means;
Control means for controlling the operation of the dissolution tank and stopping the calculation by the calculation means at the time of operation of the dissolution tank where the detection value of the hydraulic pressure detection means becomes unstable ,
A melting apparatus comprising: A water supply line for supplying water into the dissolution tank;
The container is formed in a substantially closed shape including a container containing a predetermined amount of the dissolution tank and the dialysis powder medicine, and is stirred while circulating the water supplied from the water supply line and the dialysis powder medicine in the container. A circulation line that dissolves to obtain a stock solution for dialysis of a predetermined concentration;
A discharge line for discharging the stock solution for dialysis in the dissolution tank while bypassing the storage tank;
Comprising
The control means controls the water supply operation by the water supply line, the circulation operation by the circulation line, and the discharge operation by the discharge line, and when the water supply operation, the circulation operation and the discharge operation are performed, the calculation means The melting apparatus according to claim 1, wherein the operation according to claim 1 is not performed.   The calculation means can calculate the reduction rate based on the calculated remaining amount of dialysate stock solution, and the dialysis stock solution in the storage tank is empty from the decrease rate of the dialysate solution calculated by the calculation means. The dissolution apparatus according to claim 1 or 2, further comprising determination means for estimating a time until the occurrence of the determination and determining whether or not a dialysis stock solution to be supplied is insufficient.   The said control means makes the dissolution operation | movement of the additional dialysis stock solution by the said dissolution tank performed on condition that it determined with the determination | prevention means that the stock solution for dialysis which should be supplied is insufficient. Item 4. The melting apparatus according to any one of Items 3 to 3. A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying the stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
A vent line that extends from the dissolution tank and the storage tank and is opened to the atmosphere via an air filter while being merged in the middle, and the dissolution tank and the storage tank communicated with the outside.
Hydraulic pressure detection means for continuously and in real time detecting the hydraulic pressure in the storage tank;
A method for measuring the remaining amount in a storage tank of a dissolution apparatus comprising:
Based on the hydraulic pressure detected continuously and in real time by the hydraulic pressure detection means , the calculation step can calculate the remaining amount of the dialysis stock solution in the storage tank, and the detection value of the hydraulic pressure detection means is A method for measuring a remaining amount in a storage tank of a dissolution apparatus, wherein the calculation by the calculation step is stopped during the stable operation of the dissolution tank . The dissolution apparatus comprises:
A water supply line for supplying water into the dissolution tank;
The container is formed in a substantially closed shape including a container containing a predetermined amount of the dissolution tank and the dialysis powder medicine, and is stirred while circulating the water supplied from the water supply line and the dialysis powder medicine in the container. A circulation line that dissolves to obtain a stock solution for dialysis of a predetermined concentration;
A discharge line for discharging the stock solution for dialysis in the dissolution tank while bypassing the storage tank;
And having
6. The storage tank of a melting apparatus according to claim 5, wherein when the water supply operation by the water supply line, the circulation operation by the circulation line, and the discharge operation by the discharge line are performed, the calculation by the calculation step is not performed. The remaining amount measurement method.   The calculation step can calculate the reduction rate based on the calculated remaining amount of the dialysate stock solution, and the dialysis stock solution in the storage tank is empty from the reduction rate of the dialysate solution calculated in the calculation step. The remaining amount in the storage tank of the dissolution apparatus according to claim 5 or 6, further comprising a determination step of estimating a time to be determined and determining whether or not a dialysis stock solution to be supplied is insufficient. Measurement method.   8. The lysing operation of the additional dialysis solution by the dissolution tank is performed on the condition that it is determined that the dialysis solution to be supplied is insufficient in the determination step. A method for measuring a remaining amount in a storage tank of the melting apparatus according to claim 1.

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