JP6067296B2 - Denture cleaning agent - Google Patents

Description

  The present invention relates to a denture cleaning agent that has a strong effect of forming a state in which air bubbles overlap and accumulate on the upper surface of water charged with a denture cleaning agent, and has good durability. Furthermore, this invention relates to the denture cleaning method using the said denture cleaning agent.

  Regardless of whether the denture is a complete denture or a partial denture, bacteria, biofilm, and other deposits are likely to adhere to it, and if left unwashed, it will not only cause bad breath, but also periodontal disease. It may contribute to induce oral diseases such as Therefore, it is indispensable to clean and keep the denture clean as part of oral care. Bacteria and dirt adhering to the denture cannot be sufficiently removed by cleaning with a brush, so cleaning with a denture cleaner is important.

  Generally, denture cleaning with a denture cleaning agent is performed by immersing the denture in a denture cleaning water prepared by adding the denture cleaning agent into water. Conventionally, as a denture cleaning agent, a foamed tablet type that contains a surfactant and a foaming agent and foams in water when it is put into water and bubbles accumulate on the upper surface of the water is widely used. ing. The effervescent tablet type denture cleaning agent is designed to increase the detergency by combining the chemical detergency due to the surface activation action and the physical detergency due to the foaming action. When the denture cleaning agent is poured into water, it foams in the water and at the same time the surfactant dissolves in the water, so that bubbles overlap and accumulate on the upper surface of the water (hereinafter, this state is referred to as “bubble accumulation”). When the foam accumulation reaches the maximum amount, the state is maintained for a certain period of time, and the foam accumulation disappears as the washing is completed, and eventually the foam on the water surface disappears completely.

  Conventionally, various improvements have been made on such effervescent tablet type denture cleaners in order to improve the cleaning effect and the like. For example, it has been reported that foaming power can be increased by blending polyvinylpyrrolidone and polyethylene glycol in a weight ratio of 3: 7 to 7: 3 in an effervescent tablet type denture cleaner (Patent Document 1). reference).

  In the effervescent tablet type denture cleaning agent, it is important that the upper surface of the water charged with the denture cleaning agent has a strong effect of forming a state in which air bubbles are overlapped and accumulated, and its durability is good. Thus, the foaming action is strong and its sustainability is good for improving the cleaning effect of the denture cleaner, and further effective for improving the user's visual satisfaction. Become. However, the conventional foaming tablet type denture cleaner has drawbacks such as weak foaming action or poor foaming sustainability, and there is no report on a pharmaceutical formulation that can overcome these problems. Currently.

  Against the background of such conventional technology, there is a demand for the development of an effervescent tablet type denture cleaning agent that is excellent in the action of forming foam and has good durability.

JP 2008-50323 A

  The main object of the present invention is to provide a denture cleaning agent that is excellent in the action of forming foam and has good durability.

  The present inventor has conducted extensive studies to solve the above problems, and surprisingly, a denture cleaning agent containing (A) a foaming agent, (B) an alkyl sulfoacetate salt, and (C) an alkyl sulfate salt. Has been found to be excellent in the action of forming foam and has good persistence of foam. Further, by further containing (D) silica, while maintaining the sustainability of foaming, the maximum amount of foaming is increased, and the foaming reaches the maximum amount after the denture cleaning agent is added to water. It has also been found that the time until the time can be shortened. The present invention has been completed by further studies based on this finding.

That is, this invention provides the denture cleaning agent and denture cleaning method which are hung up below.
Item 1. A denture cleaning agent comprising (A) a foaming agent, (B) an alkyl sulfoacetate salt, and (C) an alkyl sulfate salt.
Item 2. Furthermore, (D) Denture cleaning agent of claim | item 1 containing a silica.
Item 3. (B) The denture cleaning agent of claim | item 1 or 2 which contains (C) alkyl sulfate in the ratio of 20-500 weight part per 100 weight part of alkyl sulfoacetates.
Item 4. Item 4. The denture cleaner according to any one of Items 1 to 3, further comprising (E) an oil component.
Item 5. Item 5. A denture cleaning method, wherein the denture is immersed in water containing the denture cleaning agent according to any one of Items 1 to 4.

  The denture cleaning agent of the present invention is excellent in the action of forming foam during denture cleaning, and also has a drastic improvement in the sustainability of foaming, providing an excellent cleaning effect and satisfying the user visually. A feeling can be improved.

  Furthermore, in conventional denture cleaning agents, if the foam containing dirt from the dentures is dried while adhering to the wall surface of the container, the dirt remains mottled on the wall surface (ring stains), which makes the user uncomfortable. However, when the denture cleaning agent of the present invention contains an oily component and / or a terpenoid, the foam buildup disappears quickly after the denture cleaning, so that the foam containing dirt hardly remains on the wall surface of the container. In addition to the fact that the stain does not remain in the form of spots (ring stains), the denture and the container after washing can be easily rinsed, and the convenience of the user can be enhanced.

1. Denture cleaning agent The denture cleaning agent of this invention is characterized by containing (A) foaming agent, (B) alkyl sulfoacetate, and (C) alkyl sulfate. Hereinafter, the denture cleaning agent of this invention is explained in full detail.

  The foaming agent used in the denture cleaning agent of the present invention (hereinafter also referred to as “component (A)”) is not particularly limited, and is usually used in denture cleaning agents (that is, in water). Those capable of generating carbon dioxide) can be widely used.

  Specific examples of the blowing agent include a combination of carbonate, hydrogen carbonate, at least one of these double salts (hereinafter sometimes referred to as a carbonate compound) and an acid. Although it does not restrict | limit especially as carbonate, For example, the alkali metal salt of carbonates, such as sodium carbonate and potassium carbonate, is mentioned. Although it does not restrict | limit especially as hydrogencarbonate, For example, alkali metal salts of hydrogencarbonate, such as sodium hydrogencarbonate and potassium hydrogencarbonate, are mentioned. The double salt of carbonate and bicarbonate is not particularly limited, and examples thereof include sodium sesquicarbonate. These carbonic acid compounds may be used alone or in combination of two or more. In addition, the acid is not particularly limited, but for example, citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, oxalic acid and other organic acids; phosphoric acid, sulfamic acid and other inorganic acids An acid etc. are mentioned. These acids may be used individually by 1 type, and may be used in combination of 2 or more type.

  The carbonate compound constituting the foaming agent is preferably an alkali metal salt of hydrogen carbonate, more preferably sodium hydrogen carbonate. The acid constituting the foaming agent is preferably an organic acid, more preferably citric acid.

  In the foaming agent, the ratio of the carbonic acid compound and the acid is not particularly limited as long as both can react to generate carbon dioxide in water. For example, the acid is usually 50 to 120 parts by weight per 100 parts by weight of the carbonic acid compound. , Preferably 60-90 weight part, More preferably, 70-85 weight part is mentioned.

  The content of the component (A) in the denture cleaning agent of the present invention (total amount of carbonic acid compound and acid) is not particularly limited as long as the foaming action can be exerted during cleaning of the denture, but it is, for example, 10 to 70% by weight, Preferably 20 to 60% by weight, more preferably 20 to 50% by weight, and particularly preferably 30 to 60% by weight.

  The alkylsulfoacetate used in the denture cleaning agent of the present invention (hereinafter sometimes referred to as “component (B)”) is not particularly limited and is generally used as an anionic surfactant. Can be widely used.

  Although it does not restrict | limit especially about carbon number of the alkyl group which comprises alkyl sulfoacetate salt, For example, 8-20, Preferably it is 10-18, More preferably, 12-18 is mentioned. In addition, the alkyl group constituting the alkylsulfoacetate may be either linear or branched, preferably linear.

  Examples of the salt constituting the alkyl sulfoacetate include alkali metal salts such as sodium and potassium.

  In the denture cleaning agent of the present invention, among alkylsulfoacetates, laurylsulfoacetate and myristylacetate can be mentioned from the viewpoint of further improving the action of forming foam and its sustainability, preferably laurylsulfosulfate. An acetate, More preferably, a lauryl sulfoacetate alkali metal salt, More preferably, a sodium lauryl sulfoacetate is mentioned. Sodium lauryl sulfoacetate is commercially available from, for example, Nikko Chemicals Corporation.

  In the denture cleaning agent of the present invention, alkyl sulfoacetates may be used singly or in combination of two or more.

  Although it does not restrict | limit especially about content of (B) component in the denture cleaning agent of this invention, For example, 0.1-5.0 weight%, Preferably it is 0.2-2 weight%, More preferably, it is 0.25-0.25. Examples include 1.25% by weight, particularly preferably 0.25 to 1.0% by weight.

  Further, the alkyl sulfate (alkyl sulfate ester salt) (hereinafter sometimes referred to as “component (C)”) used in the denture cleaning agent of the present invention is not particularly limited, and has an anionic surface activity. What is generally used as an agent can be widely used.

  Although it does not restrict | limit especially about carbon number of the alkyl group which comprises an alkyl sulfate, For example, 8-20, Preferably it is 10-18, More preferably, 12-18 is mentioned. Moreover, the alkyl group constituting the alkyl sulfate may be either linear or branched, and preferably is linear.

  Moreover, as a salt which comprises an alkyl sulfate, alkali metal salts, such as sodium and potassium, are mentioned.

  Among alkyl sulfates, lauryl sulfate and myristyl sulfate can be mentioned from the viewpoint of further improving the action of forming foam and its sustainability, preferably lauryl sulfate, more preferably alkali metal lauryl sulfate. More preferably, sodium lauryl sulfate is used. Sodium lauryl sulfate is commercially available from, for example, Toho Chemical Industry Co., Ltd. and Kao Corporation.

  In the denture cleaning agent of the present invention, the alkyl sulfate may be used alone or in combination of two or more.

  In the denture cleaning agent of the present invention, the ratio of the component (B) and the component (C) is not particularly limited, but from the viewpoint of further improving the sustainability of foaming, it is based on 100 parts by weight of the component (B). The component (C) is usually 10 to 1000 parts by weight, preferably 20 to 500 parts by weight, more preferably 50 to 500 parts by weight, and particularly preferably 50 to 200 parts by weight.

  Although it does not restrict | limit especially about content of (C) component in the denture cleaning agent of this invention, For example, 0.1-5.0 weight%, Preferably it is 0.2-2 weight%, More preferably, it is 0.25- Examples include 1.25% by weight, particularly preferably 0.5 to 1.25% by weight.

  The denture cleaning agent of the present invention may further contain silica (hereinafter also referred to as “component (D)”). Silica is a general term for silicon dioxide or a substance composed of silicon dioxide. By containing silica, while maintaining the sustainability of foaming, increase the amount of foaming and shorten the time until foaming reaches the maximum amount after the denture cleaning agent is added to water. Therefore, it is possible to further enhance the feeling of cleaning effect and the satisfaction obtained visually.

  When the component (D) is contained in the denture cleaning agent of the present invention, the ratio of the component (D) to the total amount of the components (B) and (C) is not particularly limited, but the effect of increasing the amount of foam accumulation, and From the viewpoint of making the effect of shortening the time until foaming reaches the maximum amount more remarkably, the component (D) is usually 10 parts per 100 parts by weight of the total amount of the component (B) and the component (C). -400 weight part, Preferably it is 40-250 weight part, More preferably, 60-250 weight part is mentioned.

  When the component (D) is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 10.0% by weight, preferably 0.1 to 6.0% by weight, More preferred is 0.6 to 3.75% by weight, and particularly preferred is 0.9 to 3.75% by weight.

  In addition, the denture cleaning agent of the present invention may contain an oily component (hereinafter also referred to as “(E) component”). By containing an oily component, it becomes possible to quickly eliminate foam buildup after denture cleaning, and it is difficult to cause ring stains on the container wall caused by bubbles containing dirt after cleaning of the denture, and The denture after washing and the container can be easily rinsed, and the convenience for the user can be improved.

  Although it does not restrict | limit especially as an oil component, Specifically, hydrocarbons, such as a liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petroleum jelly; castor oil, olive oil, cacao oil, palm oil, coconut oil, palm Vegetable oils such as oil, tree wax, jojoba oil, grape seed oil, avocado oil, soybean oil; animal oils such as mink oil, egg yolk oil; waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax; lauric acid, Fatty acids such as myristic acid, stearic acid, oleic acid, isostearic acid, behenic acid; higher alcohols such as cetanol, stearyl alcohol, hexyl decanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyl myristate Rudodeshiru include octyldodecyl oleate, such as a fatty acid ester of cholesterol oleate or the like.

  When the component (E) is contained in the denture cleaning agent of the present invention, one type may be selected from the above oily components, or two or more types may be used in combination.

  When the denture cleaning agent of the present invention contains the (E) component, the ratio of the (E) component to the total amount of the (B) component and the (C) component is not particularly limited, but the disappearance of foam build-up after the denture cleaning From the viewpoint of producing the effect more remarkably, the component (E) is usually 10 to 200 parts by weight, preferably 20 to 150 parts by weight with respect to 100 parts by weight of the total amount of the components (B) and (C). More preferably, 50-100 weight part is mentioned.

  When (E) component is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 5.0% by weight, preferably 0.5 to 1.5% by weight. Can be mentioned.

  Further, the denture cleaning agent of the present invention may contain a terpenoid (hereinafter also referred to as “(F) component”). A terpenoid shows the effect | action which eliminates foaming rapidly after denture washing | cleaning similarly to the said oil-based component, and can improve a user's convenience.

  The terpenoid is not particularly limited, and specific examples include menthol, camphor, cineole, eugenol, citral, citronellal, borneol, linalool, gellarol, thymol, spiranthol, pinene, limonene and the like. One of these terpenoids may be selected, or two or more may be used in combination. These terpenoids may be used in the form of essential oils. Examples of the essential oil containing the terpenoid include spearmint oil, peppermint oil, mint oil, bergamot oil, lavender oil, eucalyptus oil, rosemary oil, thyme oil, jasmine oil, spearmint oil, rose oil, lime oil, cedarwood oil. , Perilla oil, marjoram oil, melissa oil, geranium oil, anise oil, fennel oil, orange oil and the like.

  Among these terpenoids, menthol and essential oil containing menthol are preferably used from the viewpoint of more remarkably exhibiting the effect of eliminating foaming after denture washing.

  When the component (F) is contained in the denture cleaning agent of the present invention, the ratio of the component (F) to the total amount of the component (B) and the component (C) is not particularly limited, but the disappearance of foam accumulation after the denture cleaning From the viewpoint of producing the effect more remarkably, the component (F) is usually 10 to 200 parts by weight, preferably 20 to 150 parts by weight, with respect to 100 parts by weight of the total amount of the components (B) and (C). More preferably, 50-100 weight part is mentioned.

  When the component (F) is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 5.0% by weight, preferably 0.5 to 1.5% by weight. Can be mentioned.

  In the denture cleaning agent of the present invention, in addition to the above components, chelating agents, enzymes, coloring agents, sweeteners, deodorants, foam stabilization, as long as they do not interfere with the effects of the present invention Agent, preservative, bleaching agent, antibacterial / bactericidal agent, antiseptic agent, surfactant other than the components (B) and (C), binder, lubricant, excipient, disintegrant, pH adjuster, fluid An additive such as an agent may be included.

  The denture cleaning agent of the present invention may be in the form of a solid such as a tablet, granule, granule, etc., but the denture cleaning agent of the type that settles when poured into water dentures carbon dioxide bubbles generated in water. In order to improve the cleaning effect, it is desirable that the tablet form is most easily settled among the dosage forms. Moreover, when making into tablet form, it is desirable to set the weight per tablet to an amount necessary for one denture cleaning.

  When the denture to be cleaned coexists with the denture cleaning agent of the present invention added to water, foaming by the foaming agent occurs along with dissolution of the components, and carbon dioxide bubbles generated by reaction of the component (A) The denture is cleaned by the physical stimulation caused by the contact with the denture and the surface active action by the components (B) and (C).

  Although it does not restrict | limit especially as water used when wash | cleaning dentures using the denture cleaning agent of this invention, Tap water, purified water, physiological saline, etc. are mentioned.

  When washing dentures using the denture cleaning agent of the present invention, the denture cleaning agent of the present invention may be added after immersing the denture in water, or after adding the denture cleaning agent of the present invention to water. May be immersed.

  In denture cleaning, the ratio of the denture cleaning agent and water of the present invention is appropriately set according to the composition of the denture cleaning agent of the present invention, the degree of dirt on the denture to be cleaned, etc. The denture cleaning agent is usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight with respect to 100 parts by weight of water. More specifically, in one denture cleaning, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g of the denture cleaning agent of the present invention may be added thereto.

  What is necessary is just to make the water temperature at the time of denture washing | cleaning into about 5-30 degreeC. Moreover, the time which a denture is immersed in the water which added the denture cleaning agent of this invention is about 5 minutes-about 12 hours normally, Preferably about 30 minutes-about 8 hours are mentioned.

2. Denture Cleaning Method The denture cleaning method of the present invention is a method for cleaning a denture using the denture cleaning agent. That is, the denture cleaning method of the present invention is a method for cleaning a denture by immersing the denture in water containing the denture cleaning agent. The specific embodiment of the denture cleaning method of the present invention is as described in the column of “1. Denture cleaning agent”.

  Hereinafter, the present invention will be specifically described with reference to examples. However, the present invention is not limited to these.

Test example 1
Tablet-like denture cleaning agents having the compositions shown in Table 1 were prepared. Specifically, 2.65 g of tablet-like denture cleaning agent was prepared by tableting the composition in which the components shown in Table 1 were mixed at 7 Mpa using a mold having a diameter of 25φ. .

  Each of the obtained denture cleaning agents was put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of bubble layer formed by the accumulation and accumulation of bubbles on the upper surface of water (the amount of foam accumulation) ) Was measured over time. The maximum value of the foam volume (maximum foam volume) and the foam volume after 120 seconds from the time when the maximum value of the foam volume is reached are measured. The relative value (%) of was calculated.

  The obtained results are shown in Table 1. From this result, in the denture cleaning agent (Comparative Examples 1-2) lacking either one of sodium lauryl sulfoacetate and sodium lauryl sulfate, the relative value of the persistence of foaming after 120 seconds was less than 90%, and the foaming However, in the denture cleaning agents (Examples 1 to 5) containing both of these, it was revealed that the persistence of foaming was greatly improved. In particular, when sodium lauryl sulfate is used at a rate of 20 to 500 parts by weight per 100 parts by weight of sodium lauryl sulfoacetate, the persistence of foaming is remarkably improved, especially at a rate of 50 to 500 parts by weight. In this case, the relative value of the persistence of foaming after 120 seconds was 95% or more, and it was confirmed that the sustainability of foaming was significantly improved. In addition, all the maximum foam amount of the denture cleaning agent of Examples 1-5 showed the high value.

Test example 2
In the same manner as in Test Example 1, tablet-like denture cleaning agents (2.65 g per tablet) having the composition shown in Table 2 were prepared. Each obtained denture cleaning agent is put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of foam accumulation is measured over time until the maximum amount of foam accumulation and the maximum amount of foam accumulation are reached. Was measured. Further, the relative value of the persistence of foam accumulation after 120 seconds was also calculated in the same manner as in Test Example 1.

  The obtained results are shown in Table 2. From this result, in the denture cleaning agents of Examples 6 to 10 containing silica (silicon dioxide), the persistence of foaming was maintained as compared with the denture cleaning agent of Example 3 not containing silica (after 120 seconds). It was clarified that the time to reach the maximum foam accumulation amount was shortened and the maximum foam accumulation amount was improved while the relative value of the persistence of foam accumulation was 95% or more. In particular, when the component (D) is used at a ratio of 60 to 250 parts by weight per 100 parts by weight of the total amount of the components (B) and (C), the time to reach the maximum foam accumulation amount is remarkably shortened. The maximum amount of foam was improved.

Test example 3
In the same manner as in Test Example 1, tablet-like denture cleaning agents (2.65 g per tablet) having the composition shown in Table 3 were prepared. Each obtained denture cleaning agent was put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of foam accumulated 4 hours after the insertion of the denture cleaning agent was measured.

  The obtained results are shown in Table 3. From this result, in the denture cleaners of Examples 11 to 14 containing the oil component or the terpenoid, the foam accumulation after 4 hours from the insertion of the denture cleaner can be reduced, and it is difficult for bubbles containing dirt to remain on the wall surface of the container. It has become clear that it is possible to prevent the surface of the container from remaining in the form of spots on the container wall surface (becoming a ring stain). In particular, the effects were remarkable in Examples 11 and 12 containing menthol.

Formulation Examples 1 to 68
According to the prescription example shown to Tables 4-11, the tablet-like denture cleaning agent (2.65g per one) was prepared by the method similar to Test Example 1. In particular, in the prescription examples 1 to 16, when the test of “sustainability of foaming” was performed in the same manner as in the examples, the same excellent effects as those in the above examples were recognized. Particularly good results were obtained when sodium lauryl sulfoacetate was used for the alkylsulfoacetate and sodium laurylsulfate was used for the alkylsulfate. Moreover, the prescription examples 17-28 were excellent in the persistence of foam accumulation.

  Moreover, about the prescription examples 29-68, when the measurement of "the amount of foam accumulation after 4 hours after injection | throwing-in of a denture cleaning agent" was performed similarly to an Example, the effect excellent in all was recognized similarly to an Example. It was. In particular, with regard to Formulation Examples 41 to 64, when 10 to 200 parts by weight (preferably 20 to 150 parts by weight) of terpenoid is contained with respect to 100 parts by weight of the total amount of component (B) and component (C) (silicon dioxide is added). Even if it does not contain), the effect of disappearance of foaming after denture cleaning can be enhanced, and among them, the effects of Formulation Examples 41 to 48 containing menthol as a terpenoid were high.

Claims (4)

  (A) foaming agent, (B) alkylsulfoacetate, (C) alkylsulfate, and (D) silica, and (B) alkylsulfoacetate and (C) alkylsulfate in a total amount of 100 parts by weight On the other hand, (D) Denture cleaning agent characterized by silica being 60-250 weight part.   The denture cleaning agent according to claim 1, comprising (C) alkyl sulfate in a ratio of 20 to 500 parts by weight per 100 parts by weight of (B) alkyl sulfoacetate.   The denture cleaning agent according to claim 1 or 2, further comprising (E) an oily component. In water containing the denture cleansing composition according to any one of claims 1 to 3, characterized in that immersing the denture, denture cleaning method.