JP2637672B2 - Composition for wound dressing - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

This invention relates to compositions for wound dressings. More specifically, the transparency makes it easy to visually observe the wound, and when applied to the wound, can be easily attached to and detached from the wound without causing pain to the patient, and is flexible. The present invention relates to a composition for a wound dressing material, which is rich in fragrance, gives a refreshing feeling to the wound affected area and its peripheral area, and has excellent various properties such as promoting the resistance of the living body and the healing mechanism.

[0002]

2. Description of the Related Art Conventionally, oils, ointments and the like have been used as coatings or materials for covering and protecting wounds such as burns and cuts. For example, these are applied to wounds after therapeutic treatment. Further, a method of covering with oil paper, gauze, absorbent cotton, or bandage has been generally used.

[0003] However, some of these conventional wound dressings cannot adequately retain blood, drugs, and other exudates exuding onto the wound, and others have problems with the wound application. Has some disadvantages, such as insufficient permeation of oxygen and moisture into the wound, and some of them cannot sufficiently prevent the invasion of bacteria into the wound. In many cases, the patient was distressed when attaching and detaching to and from the patient. In addition, there are many that have the property of sticking strongly to the adhesive surface of the coating wound part and its peripheral part,
The emergence of a wound dressing or material that does not have these disadvantages has been strongly desired in the art.

Some new wound dressings for improving such disadvantages of the conventional wound dressings have already been proposed. For example, wound dressing materials containing chitin and chitosan as main components have already been proposed. I have. However,
Not only is chitosan an expensive substance, but wound covering with a chitosan membrane is relatively effective when the wound has superficial bruises, but its effect is not always sufficient for deep bruises, etc. No, and especially for wounds that produce a lot of exudate,
Its absorption and the effect of suppressing exudation to the outside are not yet satisfactory.

[0005]

DISCLOSURE OF THE INVENTION The present invention solves all of the above-mentioned drawbacks of the conventional wound dressing or material, and furthermore, it is transparent so that the wound can be directly observed with the naked eye, and the damaged wound can be directly observed. Wound dressing with excellent overall properties as a wound dressing or material capable of giving a cool feeling to the skin and providing an environment suitable for phagocytosis and cell growth of leukocytes and the like in the wound under the coating. It is intended to provide a material composition.

[0006]

According to the present invention, there is provided a composition for a wound dressing, comprising, as a main component, a water-containing complex comprising a high molecular polysaccharide and a polymer of an acrylic derivative.

[0007]

The composition for a wound dressing of the present invention comprises a gel polysaccharide such as agar, pectin or arabic gum and a polymer such as an acrylic derivative such as polyacrylamide in a specific ratio, and both are specified. It is a remarkable feature that it is substantially composed of a water-containing complex having a two-mixed molecular network structure crosslinked in a state.

In the present invention, it is important that the complex is partially cross-linked between molecular chains to the extent that it allows the passage of confidential fluids and proteins of living organisms but does not allow passage of cells or bacteria. The gel-like complex of the present invention having such a partially cross-linked structure allows not only small molecules to freely pass or permeate into the gel-like complex but also proteins having a molecular weight of 1,000,000 daltons or more.

On the other hand, bacteria and single-cell microorganisms are not allowed to pass or permeate. Further, the gel-like composite of the present invention can contain a large amount of bound water, that is, about 96% of the solid component relative to the solid component, and a part of the complex-containing water dehydrated by drying or the like is strong. Shows water absorption. Also, a complex obtained by using agar or the like as a polysaccharide and blending it with polyacrylamide is particularly excellent in transparency. When a wound covering film is formed using this complex, the film is observed without peeling the wound film. be able to.

In general, a gel substance prepared from a synthetic polymer or the like causes phenomena such as shrinkage and coagulation with water containing salts such as saline, but the composite gel of the present invention is, for example, physiological saline or the like. No such change occurs even in water containing salt. Further, it has a high degree of elasticity and flexibility, and also has a property of cooling a heat generating portion and giving a refreshing feeling to a heat generating portion such as a wound.

In the specific complex of the present invention, the crosslinking of the constituent polymer chains does not necessarily mean that the molecular chains are crosslinked by a chemical bond such as a covalent bond. Hydrogen bonds between adjacent molecular chains caused by entanglement between molecular chains generated between them, and substantial cross-linking by ionic bonds or chelate bonds and coordination bonds caused by the interposition of metal ions and the like in these molecular chains It also includes states.

In particular, in the present invention, in a composite containing a polymer containing an amide group, the crosslinking between the amide group and a carboxyl group or a water group plays an important role in the physical properties of the composite. It is considered to be playing.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION

(Polymer polysaccharide) The polysaccharide used in the present invention may be any polysaccharide that can be dissolved by adding water or the like, for example, by heating or the like and then cooled to form a gel-like material. Such polysaccharides include agar, arabic gum, pectin, tragacanth, starch galactomannan, agarose, alginic acid, carrageenan,
Proteoglycans, glycoproteins and the like can be exemplified.

Among these polysaccharides, agar, pectin and carrageenan are preferred, and agar is particularly preferred. It is said that the main components of agar are agarose and amylopectin.Agarol contains many hydroxyl groups, and the gel itself is a comparative gel because the double helix structure aggregates to form a stable bridge structure. Has a very high melting point, but 90
When heated above ℃, hydrogen bonds between molecules are broken and dissolved in water, and when cooled to 30 ℃, it gels again. This agar, which is mixed with a specific amount of polyacrylamide or the like described below and mixed by heating, has cross-linking at an appropriate interval between the two molecules, and has properties most suitable as the wound dressing composition of the present invention. Form a hydrated complex.

(Acrylic Derivative or Polymer Thereof) The polymer comprising an acrylic derivative, which is another essential component of the water-containing composite of the present invention, includes acrylic acid or methacrylic acid ester, metal salt, or acrylic acid. Examples thereof include polymers and copolymers of acid amides and methacrylamides.

In the present invention, among these, the use of acrylamides, methacrylamides, and their polymers, copolymers or blends thereof is preferred. Specifically, acrylamide, methacrylamide, N-alkylacrylamides such as N-methylacrylamide, N-ethylacrylamide, N-propylacrylamide, N-isopropylacrylamide,
N-butylacrylamide, N-isobutylacrylamide, N-secondary butylacrylamide, N-tertiary butylacrylamide, N, N-dialkylacrylamide, for example, N, N-dimethylacrylamide, N, N
-A polymer, a copolymer or a blend thereof, such as diethylacrylamide. In particular, use of acrylamide or methacrylamide polymer, that is, polyacrylamide or polymethacrylamide is preferred.

(Water-containing composite and method for producing the same) The water-containing composite constituting the composition for wound dressing of the present invention comprises the above-mentioned polysaccharide capable of forming a gel, a polymer of the above-mentioned acrylic derivative, and water, The composition is such that a polysaccharide component is blended in a ratio of 10 to 300 parts by weight as a real weight (weight in a dry state) with respect to 100 parts by weight of an acrylic derivative component, excluding salt and other additives. Others are composed of moisture.

The composition of the above-mentioned composite gel varies depending on the mode of wound covering and the like. For example, in the case of use as a typical wet film, 10 to 30 parts by weight of a polymer component such as polyacrylamide, agar such as agar, etc. Sugar component 5 or 2
It has a composition of 0 parts by weight, 5 to 10 parts by weight of an additive such as sodium chloride, and 980 to 940 parts by weight of water.

In order to prepare the above-mentioned hydrogel composite, the present invention is not limited thereto. For example, powders of the above-mentioned acrylic polymer such as polyacrylamide and polysaccharide such as agar in an aqueous solution may be used. The powder or the small piece is put and heated while stirring and mixing. In the case of agar and polyacrylamide polymer, both are completely compatible by heating and stirring at a temperature of 90 ° C. or more for several tens minutes. Form a viscous solution. This is obtained by mixing a predetermined amount of salt or the like into the mixture, and then leaving the mixture to cool to gel. Also, a very small amount of a crosslinking agent such as ethylene glycol dimethacrylate, methylene bisacrylamide, etc. is blended with the above-mentioned polysaccharide and acrylic derivative-based polymer, and peroxide or light,
Crosslinking may be generated by the presence of radiation or the like.

Alternatively, crosslinking may be carried out by reacting with a molecular chain, a hydroxyl group or an amino group using an aldehyde, N-methylol compound, bisepoxy dicarboxylate or the like. Mg2 +,
Crosslinking can also be caused by intervening ions such as Ca2 +.

(Wound Dressing Composition) The wound dressing composition of the present invention is obtained by blending the above-mentioned hydrated composite with an appropriate amount of sodium chloride and, if necessary, a disinfecting agent or the like. The composition is dehydrated by drying under reduced pressure or the like, and is dried to be molded into a film or a granular gel.

When the composition of the present invention is applied as a wound dressing material, when the wound is a superficial wound such as the skin surface of a human body, the composition formed into a film is treated with the wound after treatment. And the surrounding healthy skin are cut to a size that covers both, and the wound is placed directly at the center, an absorbent material such as gauze is placed thereon, and covered with a bandage or other covering material.

When the wound portion extends to the deep portion, it is preferable that the composition formed into a granule is injected into the wound portion and then applied so as to cover the surface so that the film-like composition is further covered from above.

Hereinafter, the composition for a wound dressing material of the present invention will be described in more detail with reference to examples.

[0025]

EXAMPLE 958 g of water was added to 23 g of powdered polyacrylamide, 10 g of sodium chloride, and 9 g of dry agar chips, and the mixture was heated with stirring until it became a transparent and slightly viscous homogeneous solution. This solution was poured into a mold, cooled and formed into a sheet, to obtain a transparent and flexible sheet-like gel composition having a thickness of about 2.5 mm. This gel composition does not strongly adhere to the skin and the like. The sheet of this composition is sterilized by ethylene oxide gas sterilization method,
The following evaluation experiment was performed.

(Bacterial Penetration Test) A sheet section of the composition was placed on a nutrient agar substrate in a Petri dish, and bacteria were inoculated on the surface of the upper layer of the composition. These culture dishes were kept in a humid environment at room temperature for 4 days. 30 after bacterial transfer
Over time, all gel sheets showed dense bacterial growth. Four days later, the gel sheet on which the bacteria had grown was removed, and the nutrient-containing agar substrate was incubated for 24 hours at 37 ° C. No bacterial growth was observed in the area where the composition gel sheet was placed. That is, bacteria did not permeate the gel sheet. In addition,
Similar permeation experiments were carried out for the following strains other than bacteria, but no permeation of bacteria was observed in any case. a Salmonella typhimuriu
m) b Escherichia coili c Pseudomonas aerug
Inosa) Also, in an experiment in which Aspergillus niger was transplanted, the bacteria on the surface of the composition gel began to grow several days after transplantation, but no permeation of bacteria through the sheet was observed 10 days after transplantation. .

(Immunity Test) A sample obtained by adding a Freund's assistant to the gel composition of the present invention and uniformly mixing the mixture was injected into a rabbit. Blood samples were taken at various intervals and the sera were examined for the presence of antibodies to polyacrylamide, particularly in the composition. The antibody test used both an affinity chromatography method and a specific antibody detection method by indirect fluorescence emission. No specific antibody against the polyacrylamide component was detected by any of the methods.

(Allergy Test) A patch test was conducted on 35 healthy male and female adults. After 24 to 48 hours, no one reported irritation or discomfort to the skin. The patch test was repeated 10 times for 48 hours, and the same test was repeated 10 times after 14 days. No late allergy was observed after a total of 54 days of the study.

[0029]

Since the composition for a wound dressing of the present invention has the above-mentioned constitution, it is transparent and easy to observe the wound with the naked eye, and is easily attached and detached because it does not adhere to the wound or the skin. Moreover, since it is rich in flexibility, it can be completely covered by adapting to the shape of the affected part. In addition, it has permeability to components such as drugs and salt, and is capable of dissolving and permeating oxygen and the like, as well as permeating secretions and proteins of living organisms. On the other hand, bacteria such as bacteria have such properties that they cannot be permeated. Further, the composition has extremely excellent properties as a composition for a wound covering material, such as being completely harmless to the human body and having no allergic properties.

Claims (6)

(57) [Claims] 1. A composition for a wound dressing, comprising, as a main component, a water-containing complex comprising a polymer of a polysaccharide and a polymer of an acrylic derivative. 2. The composition for a wound dressing according to claim 1, wherein the high molecular weight polysaccharide is at least one of agar, acacia, pectin, tragacanth, galactomannan, and a composition mainly composed of these. . 3. The composition for a wound dressing according to claim 1, wherein the polymer of the acrylic derivative is a polymer of an acrylic derivative having an amide bond in a molecule. 4. The polymer of the acrylic derivative is polyacrylamide or polymethacrylamide.
The composition for a wound dressing according to the above. 5. The composition for a wound dressing according to claim 1, wherein the water-containing complex comprises a blended composition of polyacrylamide and agar. 6. The hydrated complex according to claim 1, wherein the polymer polysaccharide is 10 to 30 parts by weight based on 100 parts by weight of the polymer of the acrylic derivative.
The composition for a wound dressing according to claim 1, wherein the composition is blended at a ratio of 0 parts by weight.