IT202200007808A1 - Composizioni terapeutiche per malattie causate da accumulo di eparan solfato - Google Patents

Composizioni terapeutiche per malattie causate da accumulo di eparan solfato Download PDF

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Publication number
IT202200007808A1
IT202200007808A1 IT102022000007808A IT202200007808A IT202200007808A1 IT 202200007808 A1 IT202200007808 A1 IT 202200007808A1 IT 102022000007808 A IT102022000007808 A IT 102022000007808A IT 202200007808 A IT202200007808 A IT 202200007808A IT 202200007808 A1 IT202200007808 A1 IT 202200007808A1
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IT
Italy
Prior art keywords
eparan
accumulation
sulfate
diseases caused
therapeutic compositions
Prior art date
Application number
IT102022000007808A
Other languages
English (en)
Inventor
Luigi Michele Pavone
Annalisa Guaragna
Pasquale Valeria De
Anna Esposito
Massimo D'agostino
Original Assignee
Luigi Michele Pavone
Annalisa Guaragna
Pasquale Valeria De
Anna Esposito
D’Agostino Massimo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luigi Michele Pavone, Annalisa Guaragna, Pasquale Valeria De, Anna Esposito, D’Agostino Massimo filed Critical Luigi Michele Pavone
Priority to IT102022000007808A priority Critical patent/IT202200007808A1/it
Priority to PCT/EP2023/059966 priority patent/WO2023203004A1/en
Publication of IT202200007808A1 publication Critical patent/IT202200007808A1/it

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102022000007808A 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato IT202200007808A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato
PCT/EP2023/059966 WO2023203004A1 (en) 2022-04-20 2023-04-18 Therapeutic compositions with imino sugars for the treatment of diseases with accumulation of heparan sulfate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato

Publications (1)

Publication Number Publication Date
IT202200007808A1 true IT202200007808A1 (it) 2023-10-20

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ID=82483266

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IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato

Country Status (2)

Country Link
IT (1) IT202200007808A1 (it)
WO (1) WO2023203004A1 (it)

Citations (13)

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WO2002055064A2 (en) 2001-01-12 2002-07-18 Oxford Glycosciences (Uk) Ltd. Mucopolysaccharidosis therapies
RU2196988C2 (ru) 2000-04-19 2003-01-20 Государственный новосибирский областной клинический диагностический центр Способ диагностики мукополисахаридозов
JP2003265196A (ja) 2002-03-15 2003-09-24 Seikagaku Kogyo Co Ltd ムコ多糖症のスクリーニング方法
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US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
JP2008102114A (ja) 2005-12-27 2008-05-01 Dai Ichi Seiyaku Co Ltd ムコ多糖症の診断方法
US20090092996A1 (en) 2005-12-08 2009-04-09 Clarke Lorne A Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
EP2081023A2 (en) 2002-06-14 2009-07-22 Women's And Children's Hospital Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
US20120190642A1 (en) 2005-09-21 2012-07-26 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
WO2012177778A1 (en) 2011-06-20 2012-12-27 Mount Sinai School Of Medicine Anti-tnf- therapy for the mucopolysaccharidoses and other lysosomal disorders
US20130302308A1 (en) 2010-12-22 2013-11-14 Fondazione Telethon Therapeutic strategies to treat cns pathology in mucopolysaccharidoses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2991488A4 (en) * 2013-05-02 2016-12-21 The Chancellor Masters And Scholars Of The Univ Of Oxford INHIBITION OF GLYCOLIPIDS USING IMINOSUCKS
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection

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RU2083205C1 (ru) 1994-01-19 1997-07-10 Товарищество с ограниченной ответственностью предприятие "БИОМ" Способ лечения мукополисахаридоза
RU2196988C2 (ru) 2000-04-19 2003-01-20 Государственный новосибирский областной клинический диагностический центр Способ диагностики мукополисахаридозов
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
WO2002055064A2 (en) 2001-01-12 2002-07-18 Oxford Glycosciences (Uk) Ltd. Mucopolysaccharidosis therapies
JP2003265196A (ja) 2002-03-15 2003-09-24 Seikagaku Kogyo Co Ltd ムコ多糖症のスクリーニング方法
EP2081023A2 (en) 2002-06-14 2009-07-22 Women's And Children's Hospital Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders
KR20040084881A (ko) 2004-09-08 2004-10-06 진동규 동물 세포주를 이용한 이듀로네이트-설파타제의 발현 방법및 그 발현을 위한 세포주
KR100762945B1 (ko) 2004-09-08 2007-10-04 진동규 동물 세포주를 이용한 이듀로네이트-설파타제의 발현 방법및 그 발현을 위한 세포주
US20120190642A1 (en) 2005-09-21 2012-07-26 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
US8623910B2 (en) 2005-09-21 2014-01-07 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
US20090092996A1 (en) 2005-12-08 2009-04-09 Clarke Lorne A Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
US8105788B2 (en) 2005-12-08 2012-01-31 The University Of British Columbia Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith
JP4965999B2 (ja) 2005-12-27 2012-07-04 セント ルイス ユニバーシティ ムコ多糖症の診断方法
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JP2008102114A (ja) 2005-12-27 2008-05-01 Dai Ichi Seiyaku Co Ltd ムコ多糖症の診断方法
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
US20130302308A1 (en) 2010-12-22 2013-11-14 Fondazione Telethon Therapeutic strategies to treat cns pathology in mucopolysaccharidoses
WO2012177778A1 (en) 2011-06-20 2012-12-27 Mount Sinai School Of Medicine Anti-tnf- therapy for the mucopolysaccharidoses and other lysosomal disorders

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