IL108958A0 - Sulfonate and carbamate derivatives of 3-aroylbenzo (b) thiophenes - Google Patents

Sulfonate and carbamate derivatives of 3-aroylbenzo (b) thiophenes

Info

Publication number
IL108958A0
IL108958A0 IL10895894A IL10895894A IL108958A0 IL 108958 A0 IL108958 A0 IL 108958A0 IL 10895894 A IL10895894 A IL 10895894A IL 10895894 A IL10895894 A IL 10895894A IL 108958 A0 IL108958 A0 IL 108958A0
Authority
IL
Israel
Prior art keywords
aroylbenzo
thiophenes
sulfonate
carbamate derivatives
compounds
Prior art date
Application number
IL10895894A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL108958A0 publication Critical patent/IL108958A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL10895894A 1993-03-19 1994-03-14 Sulfonate and carbamate derivatives of 3-aroylbenzo (b) thiophenes IL108958A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/035,121 US5482949A (en) 1993-03-19 1993-03-19 Sulfonate derivatives of 3-aroylbenzo[b]thiophenes

Publications (1)

Publication Number Publication Date
IL108958A0 true IL108958A0 (en) 1994-06-24

Family

ID=21880778

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10895894A IL108958A0 (en) 1993-03-19 1994-03-14 Sulfonate and carbamate derivatives of 3-aroylbenzo (b) thiophenes

Country Status (22)

Country Link
US (5) US5482949A (zh)
EP (1) EP0617030B1 (zh)
JP (1) JPH06321937A (zh)
CN (1) CN1097420A (zh)
AT (1) ATE180479T1 (zh)
AU (1) AU670177B2 (zh)
BR (1) BR9401183A (zh)
CZ (1) CZ57894A3 (zh)
DE (1) DE69418639T2 (zh)
DK (1) DK0617030T3 (zh)
ES (1) ES2132339T3 (zh)
FI (1) FI941262A (zh)
GR (1) GR3030317T3 (zh)
HU (1) HUT70549A (zh)
IL (1) IL108958A0 (zh)
NO (1) NO940940L (zh)
NZ (1) NZ260085A (zh)
PH (1) PH30177A (zh)
SI (1) SI0617030T1 (zh)
TW (1) TW304953B (zh)
YU (1) YU12794A (zh)
ZA (1) ZA941786B (zh)

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USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
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US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
JPH08510451A (ja) * 1993-05-13 1996-11-05 ネオルックス コーポレイション 異常増殖性平滑筋細胞に関連した病因の予防及び治療
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5441964A (en) * 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US6417198B1 (en) 1993-12-21 2002-07-09 Eli Lilly And Company Methods of inhibiting CNS problems in post-menopausal women
CA2176127A1 (en) * 1993-12-21 1995-06-29 William Henry Walker Lunn Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
HUT76890A (en) * 1994-08-22 1997-12-29 Lilly Co Eli Use of benzotiophene derivatives for producing phamaceutical compositions against endometrial cancer
IL115582A0 (en) * 1994-10-14 1996-01-19 Lilly Co Eli Methods for treating resistant tumors
US6562862B1 (en) * 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
AU3953795A (en) * 1994-10-20 1996-05-15 Eli Lilly And Company Bicyclic neuropeptide y receptor antagonists
AU3953695A (en) * 1994-10-20 1996-05-15 Eli Lilly And Company Bicyclic bradykinin receptor antagonists
US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5571808A (en) * 1995-01-31 1996-11-05 Eli Lilly And Company Method for treating smoking-related bone loss
US20030083733A1 (en) * 1997-10-10 2003-05-01 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US6479517B1 (en) 1995-02-28 2002-11-12 Eli Lilly And Company Phosphorous-containing benzothiophenes
US6653328B1 (en) 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US5705507A (en) * 1995-03-10 1998-01-06 Eli Lilly And Company Aplha-substituted-3-benzyl-benzofurans
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6391892B1 (en) 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
US6451817B1 (en) 1995-03-10 2002-09-17 Eli Lilly And Company Alpha-substituted-1-benzyl-napthyls
US6384053B1 (en) 1995-03-10 2002-05-07 Eli Lilly And Company α-substituted-1-benzyl-napthyls
US6417199B1 (en) 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US5532382A (en) * 1995-03-13 1996-07-02 Eli Lilly And Company Benzothiophenes substituted at the 3-carbonyl
US5514704A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophenes to inhibit leukotrienes
US5514703A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophene compounds useful for inhibiting lipoxygenase
US20020091433A1 (en) * 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
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US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
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US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
EP0747380B1 (en) * 1995-06-07 1998-09-30 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
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US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
GB9523999D0 (en) 1995-11-23 1996-01-24 Lilly Co Eli Indolyl neuropeptide y receptor antagonists
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
WO1997017069A1 (en) * 1995-11-07 1997-05-15 Eli Lilly And Company Methods for treating resistant tumors
US6432982B1 (en) 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
WO1997030709A1 (en) * 1996-02-22 1997-08-28 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods
IL120266A (en) * 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5688796A (en) * 1996-03-12 1997-11-18 Eli Lilly And Company Heterocyclic substituted benzothiophenes, compositions, and methods
TR199801915T2 (xx) * 1996-03-26 1998-12-21 Eli Lilly And Company Benzotiofenler, bunlar� ihtiva eden form�lasyonlar ve y�ntemler.
US5843984A (en) * 1996-05-09 1998-12-01 Eli Lilly And Company Sulfated benzothiophene derivatives, methods of use and formulations containing same
IL127559A0 (en) 1996-06-20 1999-10-28 Univ Texas Compounds and methods for providing pharmacologically active preparations and uses thereof
CA2206752A1 (en) * 1996-07-02 1998-01-02 George Joseph Cullinan Benzothiophene compounds, intermediates, processes, and methods of use
CA2206997A1 (en) * 1996-07-10 1998-01-10 Eli Lilly And Company Benzothiophene compounds and methods of use
EA002022B1 (ru) * 1996-08-28 2001-12-24 Эли Лилли Энд Компани Аморфные бензотиофены, способы получения и способы применения
CA2213810C (en) * 1996-08-29 2006-06-06 Lewis Dale Pennington Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods
CA2214922A1 (en) * 1996-09-27 1998-03-27 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
US5948796A (en) * 1996-10-10 1999-09-07 Eli Lilly And Company Benzo B!thiophene compounds, intermediates, formulations, and methods
CA2217373A1 (en) * 1996-10-10 1998-04-10 Michael John Martin Benzo¬b|thiophene compounds, intermediates, formulations, and methods
CA2218756A1 (en) * 1996-10-25 1998-04-25 Kristin Sue Marron Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6025373A (en) * 1997-04-22 2000-02-15 Eli Lilly And Company Methods for reducing fibrinogen
AU7165398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
WO1998049156A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Processes for preparing benzothiophenes
CA2288144A1 (en) 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents
US6350774B1 (en) 1997-04-30 2002-02-26 Eli Lilly And Company Antithrombotic agents
ES2223129T3 (es) 1997-04-30 2005-02-16 Eli Lilly And Company Agentes antitromboticos.
ATE286395T1 (de) 1997-04-30 2005-01-15 Lilly Co Eli Antithrombotische mittel
KR20010020380A (ko) * 1997-04-30 2001-03-15 피터 지. 스트링거 벤조[ｂ]티오펜의 제조 방법 및 중간체
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
WO1998048793A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company INTERMEDIATES AND PROCESSES FOR PREPARING BENZO[b]THIOPHENES
US6008232A (en) * 1997-08-20 1999-12-28 Eli Lilly And Company Methods for preventing headaches
US6103740A (en) * 1997-08-21 2000-08-15 Eli Lilly And Company Methods for lowering platelet counts
US6017914A (en) * 1997-09-03 2000-01-25 Eli Lilly And Company Benzo[b]thiophene compounds, intermediates, formulations, and methods
US5990129A (en) * 1997-09-23 1999-11-23 Eli Lilly And Company Methods for regulating trkA expression
FR2777784B1 (fr) * 1998-04-27 2004-03-19 Arepa Composition pharmaceutique a base d'estrogene et de progesterone
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DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6353003B1 (en) 1998-06-17 2002-03-05 Eli Lilly And Company Method for reducing levels of homocysteine and C-reactive protein
EP0997460B1 (en) * 1998-10-28 2002-12-11 Eli Lilly And Company Benzothiophene compounds as antithrombotic agents and intermediates
FR2813308B1 (fr) * 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
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JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
JP3804824B2 (ja) * 2001-09-19 2006-08-02 ヤマハ株式会社 ディジタルミキサ
JP4665805B2 (ja) * 2006-03-17 2011-04-06 カシオ計算機株式会社 印字装置

Also Published As

Publication number Publication date
YU12794A (sh) 1997-01-08
US5798351A (en) 1998-08-25
ES2132339T3 (es) 1999-08-16
EP0617030A1 (en) 1994-09-28
AU670177B2 (en) 1996-07-04
DK0617030T3 (da) 1999-11-08
FI941262A (fi) 1994-09-20
NO940940D0 (no) 1994-03-16
SI0617030T1 (en) 1999-10-31
US5482949A (en) 1996-01-09
ZA941786B (en) 1995-09-14
GR3030317T3 (en) 1999-09-30
PH30177A (en) 1997-01-21
HU9400774D0 (en) 1994-06-28
US5605924A (en) 1997-02-25
DE69418639D1 (de) 1999-07-01
NZ260085A (en) 1995-12-21
TW304953B (zh) 1997-05-11
CZ57894A3 (en) 1994-12-15
FI941262A0 (fi) 1994-03-17
AU5786394A (en) 1994-09-22
US5599833A (en) 1997-02-04
HUT70549A (en) 1995-10-30
CN1097420A (zh) 1995-01-18
ATE180479T1 (de) 1999-06-15
EP0617030B1 (en) 1999-05-26
US5994371A (en) 1999-11-30
NO940940L (no) 1994-09-20
JPH06321937A (ja) 1994-11-22
DE69418639T2 (de) 1999-10-07
BR9401183A (pt) 1994-11-01

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