IE39247L - Substituted benzamides - Google Patents
Substituted benzamidesInfo
- Publication number
- IE39247L IE39247L IE93474A IE93474A IE39247L IE 39247 L IE39247 L IE 39247L IE 93474 A IE93474 A IE 93474A IE 93474 A IE93474 A IE 93474A IE 39247 L IE39247 L IE 39247L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- denotes
- optionally substituted
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pharmacologically active m-carbamoylphenylethanolamine derivatives of the accompanying formula I or their pharmaceutically acceptable salts are prepared. In the formula I: R4 and R5 denote hydrogen or lower alkyl, R6 denotes an optionally substituted alkyl group and R7 denotes an optionally substituted alkyl group. These compounds are prepared by reaction of corresponding p-hydroxy-m-carbamoylethanolamines with compounds of the formula R6W in which R6 has the said meaning and W represents halogen or a tosyloxy group. The compounds are selective blockers of ss1-adrenoreceptors having minimal effects on ss2-receptors of the peripheral circulation, e.g. of the lung. Owing to these effects, they can be employed for the treatment of cardiovascular diseases, e.g. angina pectoris, hypertension and cardiac arrhythmia. <IMAGE>
[CH611268A5]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2200473 | 1973-05-07 | ||
| GB2155373A GB1468673A (en) | 1973-05-07 | 1973-05-07 | Substituted benzamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39247L true IE39247L (en) | 1974-11-07 |
| IE39247B1 IE39247B1 (en) | 1978-08-30 |
Family
ID=26255396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE93474A IE39247B1 (en) | 1973-05-07 | 1974-05-02 | Substituted benzamides |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5069038A (en) |
| CH (2) | CH611268A5 (en) |
| DE (1) | DE2421805A1 (en) |
| DK (1) | DK141117B (en) |
| FR (1) | FR2228487B1 (en) |
| IE (1) | IE39247B1 (en) |
| LU (1) | LU70005A1 (en) |
| NL (1) | NL7406137A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4163053A (en) * | 1977-12-27 | 1979-07-31 | Schering Corporation | Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides |
| DK160936C (en) * | 1978-07-03 | 1991-10-21 | Lilly Co Eli | METHOD OF ANALOGUE FOR THE PREPARATION OF OPTICALLY ACTIVE PHENETHANOLAMINES |
-
1974
- 1974-05-02 IE IE93474A patent/IE39247B1/en unknown
- 1974-05-06 LU LU70005A patent/LU70005A1/xx unknown
- 1974-05-06 DE DE19742421805 patent/DE2421805A1/en not_active Withdrawn
- 1974-05-06 DK DK245574A patent/DK141117B/en unknown
- 1974-05-06 FR FR7415549A patent/FR2228487B1/fr not_active Expired
- 1974-05-07 NL NL7406137A patent/NL7406137A/xx not_active Application Discontinuation
- 1974-05-07 CH CH1524677A patent/CH611268A5/en not_active IP Right Cessation
- 1974-05-07 JP JP5066174A patent/JPS5069038A/ja active Pending
- 1974-05-07 CH CH630574A patent/CH611267A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH611267A5 (en) | 1979-05-31 |
| FR2228487B1 (en) | 1977-07-01 |
| IE39247B1 (en) | 1978-08-30 |
| DK141117B (en) | 1980-01-21 |
| FR2228487A1 (en) | 1974-12-06 |
| DE2421805A1 (en) | 1974-11-28 |
| CH611268A5 (en) | 1979-05-31 |
| NL7406137A (en) | 1974-11-11 |
| LU70005A1 (en) | 1975-08-20 |
| DK141117C (en) | 1980-07-07 |
| JPS5069038A (en) | 1975-06-09 |
| AU6867574A (en) | 1975-11-13 |
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