HU176820B - Process for preparing phenyl-piperazine derivatives - Google Patents

Process for preparing phenyl-piperazine derivatives Download PDF

Info

Publication number: HU176820B
Authority: HU; Hungary
Prior art keywords: phenyl; formula; piperazine; ylmethyl; compound
Prior art date: 1976-04-23

Application number

HU77LI311A

Other languages

English (en)

Hungarian (hu)

Inventor

John P Verger

William B Jamieson

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-04-23

Filing date

1977-04-22

Publication date

1981-05-28

1977-04-22 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1981-05-28 Publication of HU176820B publication Critical patent/HU176820B/hu

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HU77LI311A 1976-04-23 1977-04-22 Process for preparing phenyl-piperazine derivatives HU176820B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB16526/76A GB1575904A (en)	1976-04-23	1976-04-23	Phenyl piperazines

Publications (1)

Publication Number	Publication Date
HU176820B true HU176820B (en)	1981-05-28

Family

ID=10078930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU77LI311A HU176820B (en)	1976-04-23	1977-04-22	Process for preparing phenyl-piperazine derivatives

Country Status (34)

Country	Link
JP (1)	JPS52151183A (fr)
AR (2)	AR222003A1 (fr)
AT (1)	AT355579B (fr)
AU (1)	AU514822B2 (fr)
BE (1)	BE853899A (fr)
BG (2)	BG28055A3 (fr)
CA (1)	CA1087617A (fr)
CH (2)	CH633009A5 (fr)
CS (1)	CS196360B2 (fr)
DD (1)	DD129790A5 (fr)
DE (1)	DE2717415A1 (fr)
DK (1)	DK176177A (fr)
ES (2)	ES457988A1 (fr)
FI (1)	FI63937C (fr)
FR (1)	FR2348925A1 (fr)
GB (1)	GB1575904A (fr)
GR (1)	GR64084B (fr)
HU (1)	HU176820B (fr)
IE (1)	IE44730B1 (fr)
IL (1)	IL51787A (fr)
LU (1)	LU77170A1 (fr)
MX (1)	MX4596E (fr)
NL (1)	NL7704456A (fr)
NO (1)	NO146710C (fr)
NZ (1)	NZ183715A (fr)
OA (1)	OA05643A (fr)
PH (1)	PH14124A (fr)
PL (1)	PL117466B1 (fr)
PT (1)	PT66452B (fr)
RO (1)	RO72831A (fr)
SE (1)	SE7704536L (fr)
SU (2)	SU664564A3 (fr)
YU (1)	YU104477A (fr)
ZA (1)	ZA771849B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1601310A (en) *	1978-05-23	1981-10-28	Lilly Industries Ltd	Aryl hydantoins
DE3142608A1 (de) *	1981-10-28	1983-05-05	Basf Ag, 6700 Ludwigshafen	Polyazofarbstoffe
JPH07157477A (ja) *	1993-12-02	1995-06-20	Asahi Kagaku Kogyo Kk	チアゾール誘導体の製造方法
WO1995024399A1 (fr) *	1994-03-11	1995-09-14	Yamanouchi Pharmaceutical Co., Ltd.	Agoniste de recepteur 5-ht3, nouveau derive de thiazole et intermediaire destine a son obtention
GB9517381D0 (en) *	1995-08-24	1995-10-25	Pharmacia Spa	Aryl and heteroaryl piperazine derivatives
AU2007221021B2 (en)	2006-02-28	2013-01-17	Dart Neuroscience (Cayman) Ltd	Therapeutic piperazines as PDE4 inhibitors
US8927546B2 (en)	2006-02-28	2015-01-06	Dart Neuroscience (Cayman) Ltd.	Therapeutic piperazines

1976
- 1976-04-23 GB GB16526/76A patent/GB1575904A/en not_active Expired
1977
- 1977-03-28 NZ NZ183715A patent/NZ183715A/xx unknown
- 1977-03-28 ZA ZA00771849A patent/ZA771849B/xx unknown
- 1977-03-30 IL IL51787A patent/IL51787A/xx unknown
- 1977-03-30 CA CA275,160A patent/CA1087617A/fr not_active Expired
- 1977-03-30 IE IE671/77A patent/IE44730B1/en unknown
- 1977-04-13 CH CH525781A patent/CH633009A5/fr not_active IP Right Cessation
- 1977-04-13 MX MX775629U patent/MX4596E/es unknown
- 1977-04-13 CH CH455777A patent/CH625802A5/fr not_active IP Right Cessation
- 1977-04-14 PH PH19656A patent/PH14124A/en unknown
- 1977-04-18 AU AU24386/77A patent/AU514822B2/en not_active Expired
- 1977-04-18 PT PT66452A patent/PT66452B/pt unknown
- 1977-04-19 GR GR53236A patent/GR64084B/el unknown
- 1977-04-19 FR FR7711669A patent/FR2348925A1/fr active Granted
- 1977-04-20 OA OA56149A patent/OA05643A/fr unknown
- 1977-04-20 DE DE19772717415 patent/DE2717415A1/de not_active Withdrawn
- 1977-04-20 RO RO7790106A patent/RO72831A/fr unknown
- 1977-04-20 SE SE7704536A patent/SE7704536L/xx not_active Application Discontinuation
- 1977-04-20 BG BG037191A patent/BG28055A3/xx unknown
- 1977-04-20 BG BG036062A patent/BG27746A3/xx unknown
- 1977-04-20 ES ES457988A patent/ES457988A1/es not_active Expired
- 1977-04-21 LU LU77170A patent/LU77170A1/xx unknown
- 1977-04-21 YU YU01044/77A patent/YU104477A/xx unknown
- 1977-04-21 CS CS772668A patent/CS196360B2/cs unknown
- 1977-04-21 DK DK176177A patent/DK176177A/da not_active Application Discontinuation
- 1977-04-22 SU SU772474105A patent/SU664564A3/ru active
- 1977-04-22 AT AT285177A patent/AT355579B/de not_active IP Right Cessation
- 1977-04-22 NO NO771398A patent/NO146710C/no unknown
- 1977-04-22 PL PL1977197550A patent/PL117466B1/pl unknown
- 1977-04-22 AR AR267310A patent/AR222003A1/es active
- 1977-04-22 NL NL7704456A patent/NL7704456A/xx not_active Application Discontinuation
- 1977-04-22 BE BE6045977A patent/BE853899A/fr not_active IP Right Cessation
- 1977-04-22 FI FI771287A patent/FI63937C/fi not_active IP Right Cessation
- 1977-04-22 HU HU77LI311A patent/HU176820B/hu unknown
- 1977-04-22 DD DD7700198558A patent/DD129790A5/xx unknown
- 1977-04-23 JP JP4727677A patent/JPS52151183A/ja active Pending
- 1977-12-28 SU SU772558499A patent/SU727146A3/ru active
1978
- 1978-03-16 ES ES467948A patent/ES467948A1/es not_active Expired
- 1978-03-22 AR AR271519A patent/AR222635A1/es active

Also Published As

Publication number	Publication date
MX4596E (es)	1982-06-25
SU727146A3 (ru)	1980-04-05
DK176177A (da)	1977-10-24
ATA285177A (de)	1979-08-15
CH633009A5 (en)	1982-11-15
FI63937C (fi)	1983-09-12
IE44730L (en)	1977-10-23
SU664564A3 (ru)	1979-05-25
NO146710C (no)	1982-11-24
NL7704456A (nl)	1977-10-25
CH625802A5 (en)	1981-10-15
NO146710B (no)	1982-08-16
IE44730B1 (en)	1982-03-10
SE7704536L (sv)	1977-10-24
CS196360B2 (en)	1980-03-31
BG28055A3 (en)	1980-02-25
ES467948A1 (es)	1978-11-01
RO72831A (fr)	1983-08-03
NO771398L (no)	1977-10-25
BG27746A3 (en)	1979-12-12
AR222003A1 (es)	1981-04-15
FR2348925A1 (fr)	1977-11-18
JPS52151183A (en)	1977-12-15
IL51787A0 (en)	1977-05-31
CA1087617A (fr)	1980-10-14
FI771287A (fr)	1977-10-24
OA05643A (fr)	1981-04-30
AU2438677A (en)	1978-10-26
PT66452B (en)	1979-03-09
GB1575904A (en)	1980-10-01
AR222635A1 (es)	1981-06-15
PL197550A1 (pl)	1979-05-21
LU77170A1 (fr)	1979-01-18
DD129790A5 (de)	1978-02-08
FI63937B (fi)	1983-05-31
AU514822B2 (en)	1981-02-26
PL117466B1 (en)	1981-08-31
FR2348925B1 (fr)	1980-04-11
RO72831B (ro)	1983-07-30
ES457988A1 (es)	1978-07-16
IL51787A (en)	1980-02-29
DE2717415A1 (de)	1977-11-10
YU104477A (en)	1983-01-21
BE853899A (fr)	1977-10-24
AT355579B (de)	1980-03-10
GR64084B (en)	1980-01-21
ZA771849B (en)	1978-11-29
PT66452A (en)	1977-05-01
NZ183715A (en)	1980-04-28
PH14124A (en)	1981-02-26

Publication	Publication Date	Title
EP0149884B1 (fr)	1992-12-16	Dérivés de 5-pyridyle-1,3-thiazole, leur préparation et utilisation
AU2009209885B2 (en)	2013-12-05	Thiazole derivative and use thereof as VAP-1 inhibitor
BRPI0710266B1 (pt)	2020-07-14	Composto, medicamento, e, uso de um composto
US6919361B2 (en)	2005-07-19	Five-membered-ring compound
JP2758077B2 (ja)	1998-05-25	複素環式誘導体、その製造方法、ならびに治療的用途
EP0190015A1 (fr)	1986-08-06	Nouvelles 4H-1-benzopyranones-4 et leurs analogues contenant du soufre
US4123529A (en)	1978-10-31	Phenylpiperazine derivatives
HU176820B (en)	1981-05-28	Process for preparing phenyl-piperazine derivatives
HU207731B (en)	1993-05-28	Process for producing aryl-piperazinyl-alkylene-phenyl-p-heterocyclic compounds, pharmaceutically acceptable acid additional salts and pharmaceutical compositions containing them as active components
US3476766A (en)	1969-11-04	Certain 2,4 - diarylthiazole-5-alkanoic acids and derivatives thereof
US4147698A (en)	1979-04-03	3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
US4935424A (en)	1990-06-19	4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents
CA1333906C (fr)	1995-01-10	Derives de cycloalkylthiazole
HU214337B (hu)	1998-03-02	Eljárás 1,3,4-tiadiazin-2-on-származékok és az azokat tartalmazó gyógyszer készítmények előállítására
US4711889A (en)	1987-12-08	Schistosomicidal acridanone hydrazones
JPS6360978A (ja)	1988-03-17	アミノチアゾ−ル化合物
US4344946A (en)	1982-08-17	2,6-Diamino-benzo[1,2-d:5,4-d']bisthiazoles and salts thereof
PL164152B1 (pl)	1994-06-30	Sposób wytwarzania nowych pochodnych 2-iminobenzotiazoliny PL
US5096902A (en)	1992-03-17	Heterocyclic compounds containing nitrogen and sulfur, pharmaceutical compositions containing them and process for preparing same
KR20020058020A (ko)	2002-07-12	술포닐 옥사졸 아민 및 ５-ｈｔ６ 수용체 리간드로서의이의 용도
HU190669B (en)	1986-10-28	Process for preparing 3,4-disubstituted 1,2,5-thiadiazole-1-oxides and -1,1-dioxides
KR810000758B1 (ko)	1981-07-02	페닐 피페라진 유도체의 제조방법
JPS61115074A (ja)	1986-06-02	３，４‐ジアゾール誘導体、その製法、およびその化合物を含有する医薬品
GB2265369A (en)	1993-09-29	2-(substituted imino)-thiazolidines and process for the preparation thereof
JPS59167588A (ja)	1984-09-21	チアジアゾ−ル誘導体