HK1098164A1 - Inhibitors of serine proteases, particularly hcv ns3-ns4a protease - Google Patents

Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Info

Publication number
HK1098164A1
HK1098164A1 HK07104318.0A HK07104318A HK1098164A1 HK 1098164 A1 HK1098164 A1 HK 1098164A1 HK 07104318 A HK07104318 A HK 07104318A HK 1098164 A1 HK1098164 A1 HK 1098164A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
serine proteases
ns4a protease
particularly hcv
hcv
Prior art date
Application number
HK07104318.0A
Other languages
English (en)
Inventor
Shawn D Britt
Kevin M Cottrell
Robert B Perni
Janos Pitlik
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34079432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1098164(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HK1098164A1 publication Critical patent/HK1098164A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
HK07104318.0A 2003-07-18 2007-04-24 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease HK1098164A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48853503P 2003-07-18 2003-07-18
PCT/US2004/023054 WO2005007681A2 (en) 2003-07-18 2004-07-16 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Publications (1)

Publication Number Publication Date
HK1098164A1 true HK1098164A1 (en) 2007-07-13

Family

ID=34079432

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07104318.0A HK1098164A1 (en) 2003-07-18 2007-04-24 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Country Status (19)

Country Link
US (2) US7109172B2 (xx)
EP (3) EP2368900A3 (xx)
JP (2) JP4745230B2 (xx)
KR (2) KR20120013450A (xx)
CN (3) CN1852920B (xx)
AR (1) AR045916A1 (xx)
AU (2) AU2004257288A1 (xx)
BR (1) BRPI0412761A (xx)
CA (1) CA2532664A1 (xx)
HK (1) HK1098164A1 (xx)
IL (2) IL173180A0 (xx)
NO (1) NO20060706L (xx)
NZ (1) NZ544789A (xx)
PE (1) PE20050251A1 (xx)
RU (1) RU2412198C2 (xx)
TW (1) TW200523270A (xx)
UY (1) UY28423A1 (xx)
WO (1) WO2005007681A2 (xx)
ZA (1) ZA200601420B (xx)

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TW200526686A (en) 2003-09-18 2005-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
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SI1677827T1 (sl) * 2003-10-27 2009-06-30 Vertex Pharma Zdravilni sestavek proti virusu hepatitisa c (hcv)
US7683033B2 (en) * 2004-02-04 2010-03-23 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
BRPI0610283A2 (pt) 2005-05-13 2010-10-19 Virochem Pharma Inc composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica
EP1891089B1 (en) 2005-06-02 2014-11-05 Merck Sharp & Dohme Corp. HCV protease inhibitors in combination with food
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TW200827364A (en) * 2006-11-02 2008-07-01 Taigen Biotechnology Co Ltd HCV protease inhibitors
JP5290186B2 (ja) 2006-11-15 2013-09-18 ヴァイロケム ファーマ インコーポレイテッド フラビウイルス感染症の治療または予防用のチオフェン類似体
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US20110182850A1 (en) * 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
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WO2011159826A2 (en) 2010-06-15 2011-12-22 Vertex Pharmaceuticals Incorporated Hcv ns5b protease mutants
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EP2585448A1 (en) 2010-06-28 2013-05-01 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
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AU2011292040A1 (en) 2010-08-17 2013-03-07 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of Flaviviridae viral infections
WO2012107589A1 (en) 2011-02-11 2012-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of hcv infections
WO2013016499A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Methods for preparation of thiophene compounds
AR087346A1 (es) 2011-07-26 2014-03-19 Vertex Pharma Formulaciones de compuestos de tiofeno
WO2013072328A1 (en) 2011-11-14 2013-05-23 Sanofi Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
WO2014053533A1 (en) 2012-10-05 2014-04-10 Sanofi Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation
WO2014134251A1 (en) 2013-02-28 2014-09-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
CN105408317A (zh) 2013-03-14 2016-03-16 艾其林医药公司 用于生产Sovaprevir的方法
US9227952B2 (en) 2013-03-15 2016-01-05 Achillion Pharmaceuticals, Inc. Sovaprevir polymorphs and methods of manufacture thereof
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WO2016069574A1 (en) * 2014-10-27 2016-05-06 Inhibrx Lp Serpin fusion polypeptides and methods of use thereof
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
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CA2405043A1 (en) 2000-04-03 2001-10-11 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
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JP2005535574A (ja) * 2002-04-11 2005-11-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター
CA2495843A1 (en) 2002-09-04 2004-03-18 Mark Straubhaar Optoelectronic device for the treatment of muscle or joint pain
JP2006526011A (ja) * 2003-04-11 2006-11-16 バーテックス　ファーマシューティカルズ　インコーポレイテッド セリンプロテアーゼ（特に、ｈｃｖｎｓ３−ｎｓ４ａプロテアーゼ）のインヒビター
TW200510391A (en) * 2003-04-11 2005-03-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
UY28423A1 (es) 2003-07-18 2005-02-28 Vertex Pharma Inhibidores de proteasas serinas, en especial proteasa ns3-ns4a del vhc.-
UY28500A1 (es) * 2003-09-05 2005-04-29 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
TW200526686A (en) 2003-09-18 2005-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
CA2541634A1 (en) * 2003-10-10 2005-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
US7683033B2 (en) * 2004-02-04 2010-03-23 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
WO2008106058A2 (en) 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases

Also Published As

Publication number Publication date
WO2005007681A2 (en) 2005-01-27
EP2341065A3 (en) 2012-06-20
EP2341065A2 (en) 2011-07-06
EP2368900A2 (en) 2011-09-28
AR045916A1 (es) 2005-11-16
PE20050251A1 (es) 2005-04-13
CN1852920B (zh) 2010-12-15
AU2010257200B2 (en) 2011-10-20
ZA200601420B (en) 2007-06-27
JP4745230B2 (ja) 2011-08-10
CN101724022A (zh) 2010-06-09
RU2006105002A (ru) 2006-08-27
CN1852920A (zh) 2006-10-25
EP2368900A3 (en) 2012-07-04
JP2008500265A (ja) 2008-01-10
CN102020700A (zh) 2011-04-20
AU2004257288A1 (en) 2005-01-27
US20050107304A1 (en) 2005-05-19
NZ544789A (en) 2010-01-29
IL173180A0 (en) 2006-06-11
KR20120013450A (ko) 2012-02-14
US7109172B2 (en) 2006-09-19
UY28423A1 (es) 2005-02-28
RU2412198C2 (ru) 2011-02-20
JP2011116784A (ja) 2011-06-16
TW200523270A (en) 2005-07-16
KR20060052836A (ko) 2006-05-19
BRPI0412761A (pt) 2006-09-26
US20060211629A1 (en) 2006-09-21
US8691758B2 (en) 2014-04-08
NO20060706L (no) 2006-02-14
WO2005007681A3 (en) 2005-06-02
AU2004257288A2 (en) 2008-06-26
EP1646642A2 (en) 2006-04-19
IL218698A0 (en) 2012-05-31
CA2532664A1 (en) 2005-01-27
AU2010257200A1 (en) 2011-01-13

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150716