GB935509A - Method of preparing nucleotides - Google Patents
Method of preparing nucleotidesInfo
- Publication number
- GB935509A GB935509A GB3055/61A GB305561A GB935509A GB 935509 A GB935509 A GB 935509A GB 3055/61 A GB3055/61 A GB 3055/61A GB 305561 A GB305561 A GB 305561A GB 935509 A GB935509 A GB 935509A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrophosphate
- adenosine
- nucleotides
- examples
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002773 nucleotide Substances 0.000 title abstract 3
- 125000003729 nucleotide group Chemical group 0.000 title abstract 3
- 235000011180 diphosphates Nutrition 0.000 abstract 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- MPUAUPQFSLHOHQ-UHFFFAOYSA-N 1,2-dicyclohexylguanidine Chemical compound C1CCCCC1NC(=N)NC1CCCCC1 MPUAUPQFSLHOHQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical compound C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000012457 nonaqueous media Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate ester Chemical class 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Nucleotides are prepared by treating a nucleotide imidazole wit ammonia, a phosphate ester or phosphoric acid as shown in the following reaction scheme <FORM:0935509/IV(a)/1> Aqueous or non-aqueous media (dimethylformamide in examples) and temperatures of from -20 up to 100 DEG C. may be used. The products may be isolated as salts. Examples describe the preparation of: 1,3-dicyclohexylguanidinium adenosine-51 phosphoramidate; acridinium adenosine-51 pyrophosphate; P1,P2-diadenosine-51- pyrophosphate; and P1-adenosine-51 P2-uridine-51 pyrophosphate (along with some P1,P2-diuridine-51 pyrophosphate). Specification 935,508 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7744A US3082203A (en) | 1960-02-10 | 1960-02-10 | Novel nucleotide coenzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB935509A true GB935509A (en) | 1963-08-28 |
Family
ID=21727904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3055/61A Expired GB935509A (en) | 1960-02-10 | 1961-01-26 | Method of preparing nucleotides |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3082203A (en) |
| GB (1) | GB935509A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3321462A (en) * | 1963-07-15 | 1967-05-23 | Syntex Corp | Process for the preparation of nucleoside polyphosphates |
| FR1500763A (en) * | 1963-08-07 | 1967-11-10 | Ajinomoto Kk | Process for preparing guanosine |
| US3299042A (en) * | 1964-06-22 | 1967-01-17 | Lipkin David | Iodination of the heterocyclic bases in nucleosides, nucleotides, nucleoside-5'-polyphosphates, and nucleic acids |
| GB8827337D0 (en) * | 1988-11-23 | 1988-12-29 | Medical Res Council | Nucleoside analogues |
-
1960
- 1960-02-10 US US7744A patent/US3082203A/en not_active Expired - Lifetime
-
1961
- 1961-01-26 GB GB3055/61A patent/GB935509A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3082203A (en) | 1963-03-19 |
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