GB828344A - Veterinary compositions containing acid hydrazides - Google Patents

Abstract

The invention comprises the compounds (a) a -ethyl-n-butyric acid hydrazide, (c) a -hydroxyisobutyric acid hydrazide, (c) cyanacethydrazone of lactose, (d) glucose acethydrazone, (e) cyanacethydrazone of methyl-n-hexyl ketone, (f) cyanacethydrazone of cyclopentanone, (g) N1 - n - valeryl - N11 cyclopentylidene hydrazine, (h) isopropylidene n-valeric acid hydrazide, (i) isopropylidene glycollic hydrazide, (j) isopropylidene a -hydroxy isobutyric acid hydrazide, (k) N1 - benzylidene - N11 - carbethoxy hydrazine, (l) benzylidene n-valeric acid hydrazide, (n) benzylidene a -hydroxyisobutyric acid hydrazide, (n) on- and p-chlorobenzylidene cyanacethydrazide, (o) n-butylidene cyanacethydrazide. (a) is prepared by reacting hydrazine hydrate with the ethyl ester of pentane-g -carboxylic acid, (b) by reacting hydrazine hydrate with the methyl ester of a -hydroxyisobutyric acid, (c) and (d) by reacting the sugar with the appropriate hydrazide, (e)-(j) by reacting the appropriate ketone and hydrazide, (k)-(o) by reacting the appropriate aldehyde and hydrazide.ALSO:Veterinary compositions comprise as active ingredient not less than 0.01% by weight of an acid hydrazide of formula ACONHR1R2 wherein A stands for the residue of an organic carboxylic acid of formula ACOOH and R1 stands for hydrogen and R2 stands for hydrogen or sulphomethyl and wherein R1 and R2 may be combined to form the group = CXY wherein either X stands for hydrogen or an alkyl radical containing not more than 6 carbon atoms, and Y stands for alkyl, acyl, aryl groups optionally substituted, or X and Y are joined together with the adjacent carbon atom to form a saturated homocyclic ring, provided that when A stands for cyanomethyl R1 and R2 are not both H. Preferred compounds are glycollic acid hydrazide, n-valeric acid hydrazide, n-caproic acid hydrazide, oxal dihydrazide, isopropylidene cyanacethydrazide, benzylidene cyanacethydrazide, isopropylidene acethydrazide, isopropylidene propionhydrazide, isopropylidene n-butyric hydrazide. Many other acid hydrazides are listed. The compositions may be aqueous or non-aqueous solutions or suspensions, tablets, premixes suitable for admixture with animal feeding stuffs, animal feeding stuffs or powders which may be dispersible and contain a dispersing agent, e.g. sodium diisopropyl naphthalene sulphonate. Suitable diluents are, for example, chalk, kaolin, talc, urea, sodium sulphate, sodium chloride, magnesium sulphate and lactose. Antibacterial agents, such as sulphadimidine, procaine penicillin G and sodium penicillin G, antiprotozoal agents, such as 6 : 61-diquinolylurea dimethosulphate, anthelmintics, such as phenothiazine, hexachloroethane, piperazine, tripiperazine dicitrate pentahydrate and 1 - diethylcarbamyl - 4 - methylpiperazine dihydrogen citrate may be included.