GB2415696B - Process for preparing amlodipine mesylate monohydrate - Google Patents

Process for preparing amlodipine mesylate monohydrate

Info

Publication number
GB2415696B
GB2415696B GB0522075A GB0522075A GB2415696B GB 2415696 B GB2415696 B GB 2415696B GB 0522075 A GB0522075 A GB 0522075A GB 0522075 A GB0522075 A GB 0522075A GB 2415696 B GB2415696 B GB 2415696B
Authority
GB
United Kingdom
Prior art keywords
mesylate monohydrate
preparing amlodipine
amlodipine mesylate
preparing
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0522075A
Other versions
GB2415696A (en
GB0522075D0 (en
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Pathi L Srinivas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0309471A external-priority patent/GB0309471D0/en
Priority claimed from GB0314617A external-priority patent/GB0314617D0/en
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of GB0522075D0 publication Critical patent/GB0522075D0/en
Publication of GB2415696A publication Critical patent/GB2415696A/en
Application granted granted Critical
Publication of GB2415696B publication Critical patent/GB2415696B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB0522075A 2003-04-25 2004-04-16 Process for preparing amlodipine mesylate monohydrate Expired - Fee Related GB2415696B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0309471A GB0309471D0 (en) 2003-04-25 2003-04-25 Process
GB0314617A GB0314617D0 (en) 2003-06-23 2003-06-23 Process
PCT/GB2004/001638 WO2004096770A1 (en) 2003-04-25 2004-04-16 Process for preparing almodipine mesylate monohydrate

Publications (3)

Publication Number Publication Date
GB0522075D0 GB0522075D0 (en) 2005-12-07
GB2415696A GB2415696A (en) 2006-01-04
GB2415696B true GB2415696B (en) 2007-06-20

Family

ID=33420880

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0522075A Expired - Fee Related GB2415696B (en) 2003-04-25 2004-04-16 Process for preparing amlodipine mesylate monohydrate

Country Status (6)

Country Link
AR (1) AR044063A1 (en)
CL (1) CL2004000864A1 (en)
DE (1) DE112004000712T5 (en)
GB (1) GB2415696B (en)
PA (1) PA8601501A1 (en)
WO (1) WO2004096770A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1152013C (en) * 2001-11-22 2004-06-02 张喜田 Levo-amlodipine salt able to generate hydrate and its hydrate and preparation
US20230023131A1 (en) * 2019-12-09 2023-01-26 Kunming Sinoway Natural Pharmaceuticals Co., Ltd. Amlodipine mesylate monohydrate preparation method therefor and use thereof
CN112538044B (en) * 2019-12-09 2021-08-13 昆明赛诺制药股份有限公司 Amlodipine mesylate monohydrate, and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) * 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
EP0244944A2 (en) * 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
EP1221438A2 (en) * 2001-01-09 2002-07-10 Siegfried Ltd. Amlodipine mesylate salts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) * 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
EP0244944A2 (en) * 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
EP1221438A2 (en) * 2001-01-09 2002-07-10 Siegfried Ltd. Amlodipine mesylate salts

Also Published As

Publication number Publication date
PA8601501A1 (en) 2004-12-16
GB2415696A (en) 2006-01-04
WO2004096770A1 (en) 2004-11-11
GB0522075D0 (en) 2005-12-07
CL2004000864A1 (en) 2005-04-22
DE112004000712T5 (en) 2006-10-19
AR044063A1 (en) 2005-08-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20130416