GB1253548A - Improvements in or relating to benzylideneamino guanidine derivatives - Google Patents

Improvements in or relating to benzylideneamino guanidine derivatives

Info

Publication number
GB1253548A
GB1253548A GB61608/68A GB6160868A GB1253548A GB 1253548 A GB1253548 A GB 1253548A GB 61608/68 A GB61608/68 A GB 61608/68A GB 6160868 A GB6160868 A GB 6160868A GB 1253548 A GB1253548 A GB 1253548A
Authority
GB
United Kingdom
Prior art keywords
reacting
prepared
appropriate benzaldehyde
relating
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB61608/68A
Inventor
William Joseph Houlihan
Robert Everett Manning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1253548A publication Critical patent/GB1253548A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,253,548 Benzylidene-aminoguanidine derivatives. SANDOZ Ltd. 30 Dec., 1968 [22 Jan., 1968; 10 July, 1968; 16 Sept., 1968], No. 61608/68. Heading C2C. Novel compounds I: where R 1 and R 2 are H, Cl or F, with the proviso that the benzene ring is at least monosubstituted, are prepared by reacting an appropriate benzaldehyde with 1-amino-3-hydroxy-guanidine or reacting an appropriate benzaldehyde 5-alkylisothiosemicarbazone III: where R 3 is 1-4 C alkyl with hydroxylamine. Compounds III may be prepared by reacting an apropriate thiosemicarbazone with an alkyl halide to give the acid addition salt followed by formation of the free base. The thiosemicarbazones may be prepared by reacting an appropriate benzaldehyde with Pharmaceutical compositions comprise a compound I together with a suitable excipient and have hypotensive activity when administered orally or parenterally.
GB61608/68A 1968-01-22 1968-12-30 Improvements in or relating to benzylideneamino guanidine derivatives Expired GB1253548A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69930968A 1968-01-22 1968-01-22
US74361368A 1968-07-10 1968-07-10
US76235668A 1968-09-16 1968-09-16

Publications (1)

Publication Number Publication Date
GB1253548A true GB1253548A (en) 1971-11-17

Family

ID=27418682

Family Applications (2)

Application Number Title Priority Date Filing Date
GB09402/71A Expired GB1253549A (en) 1968-01-22 1968-12-30 Aminoguanidine derivatives
GB61608/68A Expired GB1253548A (en) 1968-01-22 1968-12-30 Improvements in or relating to benzylideneamino guanidine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB09402/71A Expired GB1253549A (en) 1968-01-22 1968-12-30 Aminoguanidine derivatives

Country Status (12)

Country Link
BE (1) BE727146A (en)
CA (1) CA953735A (en)
CH (2) CH537372A (en)
DE (1) DE1902449C2 (en)
ES (3) ES362712A1 (en)
FR (3) FR2000512B1 (en)
GB (2) GB1253549A (en)
IE (1) IE32943B1 (en)
IL (1) IL31452A (en)
MX (1) MX3183E (en)
NL (1) NL6818769A (en)
SE (1) SE374740B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH523232A (en) * 1968-12-16 1972-05-31 Sandoz Ag Process for the preparation of a benzylidene aminoguanidine
FR2324294A1 (en) * 1975-09-22 1977-04-15 Roussel Uclaf NEW DELAYED-ACTION HYPOTENSIVE MEDICINAL PRODUCT, AS WELL AS THE PROCESS FOR PREPARING THIS NEW MEDICINAL PRODUCT

Also Published As

Publication number Publication date
FR2061583A1 (en) 1971-06-25
IL31452A (en) 1972-06-28
GB1253549A (en) 1971-11-17
ES362712A1 (en) 1970-11-16
FR2000512A1 (en) 1969-09-12
FR2059987A1 (en) 1971-06-11
CA953735A (en) 1974-08-27
ES374472A1 (en) 1972-04-01
IE32943B1 (en) 1974-01-23
FR2000512B1 (en) 1973-01-12
SE374740B (en) 1975-03-17
MX3183E (en) 1980-06-17
IE32943L (en) 1969-07-22
BE727146A (en) 1969-07-22
ES374475A1 (en) 1972-04-01
CH537372A (en) 1973-07-13
DE1902449C2 (en) 1983-10-20
IL31452A0 (en) 1969-03-27
DE1902449A1 (en) 1969-08-28
NL6818769A (en) 1969-07-24
CH537370A (en) 1973-05-31

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