FR2493848B2 - Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2493848B2
FR2493848B2 FR8023785A FR8023785A FR2493848B2 FR 2493848 B2 FR2493848 B2 FR 2493848B2 FR 8023785 A FR8023785 A FR 8023785A FR 8023785 A FR8023785 A FR 8023785A FR 2493848 B2 FR2493848 B2 FR 2493848B2
Authority
FR
France
Prior art keywords
granatane
tropane
derivatives
novel
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8023785A
Other languages
English (en)
Other versions
FR2493848A2 (fr
Inventor
Bernard Bucher
Philippe Dostert
Thierry Imbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8023785A priority Critical patent/FR2493848B2/fr
Priority to CH6772/81A priority patent/CH651561A5/fr
Priority to GR66378A priority patent/GR75112B/el
Priority to SE8106425A priority patent/SE448457B/sv
Priority to IT24835/81A priority patent/IT1140040B/it
Priority to BE0/206420A priority patent/BE890962R/fr
Priority to US06/318,244 priority patent/US4434170A/en
Priority to GB8133254A priority patent/GB2088364B/en
Priority to CA000389504A priority patent/CA1209574A/fr
Priority to LU83737A priority patent/LU83737A7/fr
Priority to ES507394A priority patent/ES507394A0/es
Priority to ZA817675A priority patent/ZA817675B/xx
Priority to DE19813144183 priority patent/DE3144183A1/de
Priority to NL8105042A priority patent/NL8105042A/nl
Priority to JP56178920A priority patent/JPS57108090A/ja
Publication of FR2493848A2 publication Critical patent/FR2493848A2/fr
Application granted granted Critical
Publication of FR2493848B2 publication Critical patent/FR2493848B2/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8023785A 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique Expired FR2493848B2 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR8023785A FR2493848B2 (fr) 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
CH6772/81A CH651561A5 (fr) 1980-11-07 1981-10-23 Derives des nor-tropane et granatane et leur procede de preparation.
GR66378A GR75112B (fr) 1980-11-07 1981-10-29
SE8106425A SE448457B (sv) 1980-11-07 1981-10-30 Derivat av nor-tropan och granatan, deras framstelling och farmaceutiska komposition
IT24835/81A IT1140040B (it) 1980-11-07 1981-11-03 Derivati di nor-tropano e granatano, loro procedimento di preparazione e loro applicazione in terapia
BE0/206420A BE890962R (fr) 1980-11-07 1981-11-03 Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
GB8133254A GB2088364B (en) 1980-11-07 1981-11-04 Derivatives of nortropane and granatane
US06/318,244 US4434170A (en) 1980-11-07 1981-11-04 Nor-tropane derivatives, and their application in therapeutics
CA000389504A CA1209574A (fr) 1980-11-07 1981-11-05 Derives de nor-tropane et de granatane, procede de preparation et application en therapeutique
LU83737A LU83737A7 (fr) 1980-11-07 1981-11-05 Nouveaux derives des nor-tropane et granatane,leur procede de preparation et leur application en therapeutique
ES507394A ES507394A0 (es) 1980-11-07 1981-11-05 Mejoras en el objeto de la patente de invencion n.487.721 por procedimiento de preparacion de nuevos derivados del nortropano.
ZA817675A ZA817675B (en) 1980-11-07 1981-11-06 New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeutics
DE19813144183 DE3144183A1 (de) 1980-11-07 1981-11-06 "neue derivate des nortropans und granatans, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel"
NL8105042A NL8105042A (nl) 1980-11-07 1981-11-07 Nieuwe nor-tropaan- en granataanverbindingen alsmede werkwijze ter bereiding en de therapeutische toepassing van deze verbindingen.
JP56178920A JPS57108090A (en) 1980-11-07 1981-11-07 Novel nortropane and granatane derivatives, manufacture and use as medicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8023785A FR2493848B2 (fr) 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2493848A2 FR2493848A2 (fr) 1982-05-14
FR2493848B2 true FR2493848B2 (fr) 1986-05-16

Family

ID=9247763

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8023785A Expired FR2493848B2 (fr) 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Country Status (15)

Country Link
US (1) US4434170A (fr)
JP (1) JPS57108090A (fr)
BE (1) BE890962R (fr)
CA (1) CA1209574A (fr)
CH (1) CH651561A5 (fr)
DE (1) DE3144183A1 (fr)
ES (1) ES507394A0 (fr)
FR (1) FR2493848B2 (fr)
GB (1) GB2088364B (fr)
GR (1) GR75112B (fr)
IT (1) IT1140040B (fr)
LU (1) LU83737A7 (fr)
NL (1) NL8105042A (fr)
SE (1) SE448457B (fr)
ZA (1) ZA817675B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
EP0067615B1 (fr) * 1981-06-17 1986-01-08 Beecham Group Plc Dérivés thioalkyl d'azabicyclobenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant
GB2111479A (en) * 1981-10-01 1983-07-06 Beecham Group Plc Benzamides
EP0083737A1 (fr) * 1981-12-15 1983-07-20 Beecham Group Plc N-azabicycloalcan benzamides, procédé de préparation et les compositions pharmaceutiques les contenant
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
CA1244028A (fr) * 1983-04-14 1988-11-01 Hans Maag Derives de pyrimidine
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
DE3445377A1 (de) * 1983-12-23 1985-07-04 Sandoz-Patent-GmbH, 7850 Lörrach Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
EP0189002B1 (fr) * 1984-12-20 1993-03-03 Sandoz Ag Traitement de maladies gastro-intestinales utilisant des 5-HT3 antagonistes
EP0201165B1 (fr) * 1985-03-14 1994-07-20 Beecham Group Plc Médicaments pour le traitement de l'éméticité
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
GB9027098D0 (en) * 1990-12-13 1991-02-06 Beecham Group Plc Pharmaceuticals
DE69319939T2 (de) * 1992-02-04 1999-02-18 Eisai Co., Ltd., Tokio/Tokyo Aminobenzoesäure Derivate
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
JP2007523905A (ja) * 2004-02-18 2007-08-23 アストラゼネカ アクチボラグ 化合物
ES2322709T3 (es) * 2004-02-18 2009-06-25 Astrazeneca Ab Derivados de benzamida y su uso como agentes activadores de la glucocinasa.
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
BRPI0516595A (pt) 2004-10-16 2008-09-23 Astrazeneca Ab processo para fabricar um composto, e, composto
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
WO2006125958A1 (fr) * 2005-05-24 2006-11-30 Astrazeneca Ab Derives d’imidazol[4,5b]pyridine/pyrazine et purine substitues en 2-phenyl en tant que modulateurs de la glucokinase
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
AU2006268406C1 (en) * 2005-07-09 2011-02-24 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
AR064625A1 (es) * 2006-12-21 2009-04-15 Astrazeneca Ab Forma cristalina de 3-{[5-(azetidin-1-ilcarbonil)pirazin-2-il]oxi}-5-[(1-metiletil)oxi]-n-1h-pirazol-3-ilbenzamida
EP2324028A2 (fr) * 2008-08-04 2011-05-25 AstraZeneca AB Agents thérapeutiques 414
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
WO2010116177A1 (fr) 2009-04-09 2010-10-14 Astrazeneca Ab Dérivé de pyrazolo [4,5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
WO2010116176A1 (fr) * 2009-04-09 2010-10-14 Astrazeneca Ab Dérivé de pyrazolo [4, 5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134782A (en) 1964-05-26 Chjxch-
GB774858A (en) 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation
CH374679A (de) 1958-11-26 1964-01-31 Sandoz Ag Verfahren zur Herstellung von neuen Tropan-Derivaten
US4179567A (en) 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CA1209574A (fr) 1986-08-12
ES8301979A2 (es) 1983-02-01
NL8105042A (nl) 1982-06-01
FR2493848A2 (fr) 1982-05-14
SE448457B (sv) 1987-02-23
JPS6344753B2 (fr) 1988-09-06
SE8106425L (sv) 1982-05-08
US4434170A (en) 1984-02-28
GB2088364A (en) 1982-06-09
DE3144183C2 (fr) 1992-01-23
GB2088364B (en) 1984-10-31
ES507394A0 (es) 1983-02-01
BE890962R (fr) 1982-05-03
DE3144183A1 (de) 1982-08-12
IT1140040B (it) 1986-09-24
JPS57108090A (en) 1982-07-05
IT8124835A0 (it) 1981-11-03
CH651561A5 (fr) 1985-09-30
ZA817675B (en) 1982-10-27
LU83737A7 (fr) 1983-09-01
GR75112B (fr) 1984-07-13

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