FR2260330A1 - Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index - Google Patents

Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index

Info

Publication number
FR2260330A1
FR2260330A1 FR7404096A FR7404096A FR2260330A1 FR 2260330 A1 FR2260330 A1 FR 2260330A1 FR 7404096 A FR7404096 A FR 7404096A FR 7404096 A FR7404096 A FR 7404096A FR 2260330 A1 FR2260330 A1 FR 2260330A1
Authority
FR
France
Prior art keywords
pyridoxine
hypolipaemiant
therapeutic index
hypocholesterolemiant
nicotinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7404096A
Other languages
French (fr)
Other versions
FR2260330B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Innothera SAS
Original Assignee
Laboratoires Innothera SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Innothera SAS filed Critical Laboratoires Innothera SAS
Priority to FR7404096A priority Critical patent/FR2260330A1/en
Publication of FR2260330A1 publication Critical patent/FR2260330A1/en
Application granted granted Critical
Publication of FR2260330B1 publication Critical patent/FR2260330B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Pyridoxine N-oxynicotinate (I): is a hypolipaemiant and hypocholesterolemaint, useful in the treatment of atherosclerous disorders which may be associated with lipidic perturbation such as coronary insufficiency, arterial hypertension etc. (I) has a better therapeutic index than other hypolipemiants such as ethyl 2-p-chlorophenoxy isobutyl rate. (I) are prepd. by mixing an aq. alcoholic soln. of N-oxynicotnic acid with an alcoholic soln. of pyridoxine.
FR7404096A 1974-02-07 1974-02-07 Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index Granted FR2260330A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7404096A FR2260330A1 (en) 1974-02-07 1974-02-07 Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7404096A FR2260330A1 (en) 1974-02-07 1974-02-07 Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index

Publications (2)

Publication Number Publication Date
FR2260330A1 true FR2260330A1 (en) 1975-09-05
FR2260330B1 FR2260330B1 (en) 1977-11-04

Family

ID=9134613

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7404096A Granted FR2260330A1 (en) 1974-02-07 1974-02-07 Pyridoxine N-oxy nicotinate - hypolipaemiant and hypocholesterolemiant of good therapeutic index

Country Status (1)

Country Link
FR (1) FR2260330A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019324A1 (en) * 1993-02-23 1994-09-01 Laboratori Baldacci Spa Process for the preparation of pyridoxine 5-oxo-2-pyrrolidone carboxylate
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
WO2013014060A1 (en) 2011-07-26 2013-01-31 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
WO2015140054A1 (en) 2014-03-19 2015-09-24 Boehringer Ingelheim International Gmbh Heteroaryl syk inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3705549A1 (en) 1987-02-18 1988-09-01 Ulrich Speck USE OF PYRIDOXINE DERIVATIVES IN THE PROPHYLAXIS AND THERAPY OF HYPERLIPIDAEMIA AND ATHEROSCLEROSIS

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019324A1 (en) * 1993-02-23 1994-09-01 Laboratori Baldacci Spa Process for the preparation of pyridoxine 5-oxo-2-pyrrolidone carboxylate
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
WO2013014060A1 (en) 2011-07-26 2013-01-31 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
WO2015140054A1 (en) 2014-03-19 2015-09-24 Boehringer Ingelheim International Gmbh Heteroaryl syk inhibitors
WO2015140055A1 (en) 2014-03-19 2015-09-24 Boehringer Ingelheim International Gmbh Heteroaryl syk inhibitors
WO2015140051A1 (en) 2014-03-19 2015-09-24 Boehringer Ingelheim International Gmbh Heteroaryl sik inhibitors

Also Published As

Publication number Publication date
FR2260330B1 (en) 1977-11-04

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