FI20050467A - Methods for promoting growth hormone release in an animal - Google Patents

Methods for promoting growth hormone release in an animal Download PDF

Info

Publication number
FI20050467A
FI20050467A FI20050467A FI20050467A FI20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A
Authority
FI
Finland
Prior art keywords
growth hormone
animal
methods
promoting growth
hormone release
Prior art date
Application number
FI20050467A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI120691B (en
Inventor
Cyril Y Bowers
David H Coy
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of FI20050467A publication Critical patent/FI20050467A/en
Application granted granted Critical
Publication of FI120691B publication Critical patent/FI120691B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel peptides of the formula A1-A2-Ala-Trp-DPhe-A5 are disclosed which promote the release of growth hormone when administered to animals. These peptides can be used therapeutically.
FI20050467A 1991-08-22 2005-05-02 Non-therapeutic method for promoting release of growth hormone in animals FI120691B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74835091 1991-08-22
US07/748,350 US5663146A (en) 1991-08-22 1991-08-22 Polypeptide analogues having growth hormone releasing activity
PCT/US1992/007026 WO1993004081A1 (en) 1991-08-22 1992-08-20 Peptides having growth hormone releasing activity
US9207026 1992-08-20

Publications (2)

Publication Number Publication Date
FI20050467A true FI20050467A (en) 2005-05-02
FI120691B FI120691B (en) 2010-01-29

Family

ID=25009088

Family Applications (2)

Application Number Title Priority Date Filing Date
FI940807A FI120095B (en) 1991-08-22 1994-02-21 A process for the preparation of peptides having growth hormone releasing activity
FI20050467A FI120691B (en) 1991-08-22 2005-05-02 Non-therapeutic method for promoting release of growth hormone in animals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI940807A FI120095B (en) 1991-08-22 1994-02-21 A process for the preparation of peptides having growth hormone releasing activity

Country Status (26)

Country Link
US (2) US5663146A (en)
EP (1) EP0605484B1 (en)
JP (1) JP3179489B2 (en)
KR (1) KR100247212B1 (en)
CN (1) CN1035256C (en)
AT (1) ATE172742T1 (en)
AU (1) AU666673B2 (en)
BG (1) BG62655B1 (en)
BR (2) BR9206398A (en)
CA (1) CA2116120C (en)
CZ (1) CZ293281B6 (en)
DE (1) DE69227462T2 (en)
DK (1) DK0605484T3 (en)
ES (1) ES2124263T3 (en)
FI (2) FI120095B (en)
HU (1) HU223664B1 (en)
IL (1) IL102848A (en)
MX (1) MX9204861A (en)
NO (1) NO314695B1 (en)
NZ (1) NZ244034A (en)
PL (1) PL169562B1 (en)
RO (1) RO112507B1 (en)
RU (1) RU2126014C1 (en)
SK (1) SK282895B6 (en)
WO (1) WO1993004081A1 (en)
ZA (1) ZA926337B (en)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698015A1 (en) 1993-05-14 1996-02-28 Genentech, Inc. Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
IL112112A (en) * 1993-12-23 2000-06-29 Novo Nordisk As Peptides with growth hormone releasing properties and pharmaceutical compositions containing them
RU2167881C2 (en) * 1993-12-23 2001-05-27 Ново Нордиск А/С Compounds promoting growth hormone release
US20020111461A1 (en) * 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
AU711104B2 (en) * 1995-06-22 1999-10-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
JP4359859B2 (en) * 1996-04-24 2009-11-11 サファイア セラピューティクス，インコーポレイティド Compounds with growth hormone releasing properties
AU7906998A (en) 1997-06-20 1999-01-04 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
ZA987383B (en) * 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
WO1999036431A1 (en) 1998-01-16 1999-07-22 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1999039730A1 (en) * 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6682908B1 (en) 1998-07-10 2004-01-27 Merck & Co., Inc. Mouse growth hormone secretagogue receptor
JP2002520011A (en) 1998-07-13 2002-07-09 メルク・アンド・カンパニー・インコーポレーテッド Growth hormone secretagogue-related receptors and nucleic acids
US6645726B1 (en) 1998-08-10 2003-11-11 Merck & Co., Inc. Canine growth hormone secretagogue receptor
JP2002525265A (en) 1998-08-14 2002-08-13 アドミニストレイターズ オブ ザ トゥレーン エジュケーショナル ファウンド Compound having growth hormone releasing activity
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US7022677B1 (en) 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
EP1158996A4 (en) 1999-02-18 2005-01-12 Kaken Pharma Co Ltd Novel amide derivatives as growth hormone secretagogues
US6828331B1 (en) * 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
WO2001006988A2 (en) * 1999-07-26 2001-02-01 Baylor College Of Medicine Super-active porcine growth hormone releasing hormone analog
US20040192593A1 (en) * 1999-07-26 2004-09-30 Baylor College Of Medicine Protease resistant ti-growth hormone releasing hormone
WO2001026630A1 (en) * 1999-10-12 2001-04-19 Kaken Pharmaceutical Co., Ltd. Powdery inhalational preparations and process for producing the same
UA73530C2 (en) 1999-11-10 2005-08-15 Ново Нордіск А/С A compound having properties to release the growth hormone
JP3498041B2 (en) * 2000-05-29 2004-02-16 科研製薬株式会社 Nasal formulation containing pralmorelin
ATE446758T1 (en) 2000-05-31 2009-11-15 Pfizer Prod Inc USE OF GROWTH HORMONE SECRETAGOGENES TO PROMOTE DIGESTIVE MOTILITY
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US7645898B2 (en) 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
AU2002233082B2 (en) 2001-02-02 2005-11-10 Conjuchem Biotechnologies Inc. Long lasting growth hormone releasing factor derivatives
US7125840B2 (en) * 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
CN100417419C (en) * 2001-10-26 2008-09-10 贝勒医学院 Composition and method to alter lean body mass and bone properties in a subject
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
BR0214869A (en) 2001-12-11 2005-03-08 Advisys Inc Plasmid-mediated supplementation for treatment of chronically ill individuals
US7015219B2 (en) 2001-12-19 2006-03-21 Bristol-Myers Squibb Company 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators
US7250405B2 (en) * 2002-02-07 2007-07-31 Baylor College Of Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7381730B2 (en) 2002-03-15 2008-06-03 Bristol-Myers Squibb Company 3-arylquinazoline derivatives as selective estrogen receptor beta modulators
DE60306636T2 (en) * 2002-04-09 2007-07-05 Eli Lilly And Co., Indianapolis WACHSTUMHORMONSEKRETIONSFÖRDERER
US20060167268A1 (en) * 2002-04-09 2006-07-27 Eli Lilly And Company, Patent Division, Growth hormone secretagogues
AU2003225305A1 (en) 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
AU2003259340A1 (en) 2002-08-23 2004-03-11 Gestion Univalor Societe En Commandite Growth hormone-releasing peptides in the treatment of prevention of atherosclerosis and hypercholesterolemia
AU2003302084A1 (en) 2002-11-15 2004-06-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
US20040204358A1 (en) * 2003-01-28 2004-10-14 Advisys, Inc. Reducing culling in herd animals growth hormone releasing hormone (GHRH)
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
US7557143B2 (en) 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US7265145B2 (en) 2003-05-28 2007-09-04 Bristol-Myers Squibb Company Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method
US7459460B2 (en) 2003-05-28 2008-12-02 Bristol-Myers Squibb Company Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
US7361642B2 (en) * 2003-08-04 2008-04-22 Vgx Pharmaceuticals, Inc. Canine specific growth hormone releasing hormone
AU2003272814A1 (en) 2003-10-02 2005-05-19 Ibrahim Al-Habdan Peptide for promoting healing of fractures
US8188056B2 (en) * 2003-12-31 2012-05-29 Vgx Pharmaceuticals, Inc. Reducing arthritis and lameness in subjects by growth hormone releasing hormone (GHRH) supplementation
DE602005027661D1 (en) * 2004-01-20 2011-06-09 VGX Pharmaceuticals LLC CORROSIVE HORMONE (GHRH) FROM MUSCLE CELLS BY SPECIFIC SPECIFIC SIGNAL PEPTIDE
US20050164952A1 (en) * 2004-01-23 2005-07-28 Vital Pharmaceuticals, Inc. Delivery system for growth hormone releasing peptides
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
MX2007000893A (en) * 2004-07-23 2007-04-18 Advisys Inc Growth hormone releasing hormone enhances the immune response induced by vaccination.
US20080261873A1 (en) 2004-08-18 2008-10-23 Elixir Pharmaceuticals, Inc. Growth-Hormone Secretagogues
WO2006116401A1 (en) 2005-04-28 2006-11-02 Bristol-Myers Squibb Company C-5 substituted quinazolinone derivatives as selective estrogen receptor beta modulators
PT2425715E (en) 2005-08-31 2014-04-14 Univ Tennessee Res Foundation Treating symptoms of renal disease with selective androgen receptor modulators (sarm)
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
US8058253B2 (en) * 2006-07-06 2011-11-15 Vgx Pharmaceuticals, Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
MX2009000385A (en) 2006-07-12 2009-04-06 Univ Tennessee Res Foundation Substituted acylanilides and methods of use thereof.
RS54542B1 (en) 2006-08-02 2016-06-30 Cytokinetics, Inc. Certain chemical entities, compositions and methods comprising imidazopyrimidines
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
CA2660570C (en) 2006-08-24 2016-08-09 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
AU2008241532A1 (en) 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US20100099640A1 (en) 2007-05-04 2010-04-22 Joannes Geuns Tissue degeneration protection
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
WO2009155481A1 (en) 2008-06-20 2009-12-23 Gtx, Inc. Metabolites of selective androgen receptor modulators and methods of use thereof
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
CN108143728A (en) 2012-07-13 2018-06-12 Gtx公司 Purposes of the selective androgen receptor modulators in breast cancer is treated
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
AU2013335678B2 (en) 2012-10-24 2017-10-26 Daiichi Sankyo Company,Limited Therapeutic agent for amyotrophic lateral sclerosis
EP2983694B1 (en) 2013-04-08 2022-06-22 President and Fellows of Harvard College Compositions for rejuvenating skeletal muscle stem cells
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
MX2016015467A (en) 2014-05-30 2017-03-23 Pfizer Carbonitrile derivatives as selective androgen receptor modulators.
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
MA56396A (en) 2019-06-27 2022-05-04 Cytokinetics Inc 1-(2-((((TRANS)-3-FLUORO-1-(3-FLUOROPYRIDIN-2-YL)CYCLOBUTYL)METHYL)AMINO)PYRIMIDIN-5-YL)-1H-PYRROLE-3-CARBOXAMIDE POLYMORPHS
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228158A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) * 1979-03-30 1980-10-07 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) * 1979-03-30 1980-09-23 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4410513A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
BR8208035A (en) * 1981-12-28 1983-11-22 Beckman Instruments Inc SYNTHETIC PEPTIDEOS HAVING HORMONE RELEASE ACTIVITY FROM PITUITARY GROWTH
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
EP0398961B1 (en) * 1988-01-28 1994-11-02 Polygen Holding Corporation Polypeptide compounds having growth hormone releasing activity
ATE122357T1 (en) * 1988-01-28 1995-05-15 Polygen Holding Corp POLYPEPTIDES WITH A HORMONE-GROWTH-LIBERATING EFFECT.
WO1989010933A1 (en) * 1988-05-11 1989-11-16 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
IL98910A0 (en) * 1990-07-24 1992-07-15 Polygen Holding Corp Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
CA2086416A1 (en) 1990-07-24 1992-01-25 John C. Hubbs Process for synthesizing peptides
US5486505A (en) * 1990-07-24 1996-01-23 Polygen Holding Corporation Polypeptide compounds having growth hormone releasing activity

Also Published As

Publication number Publication date
CN1035256C (en) 1997-06-25
BG62655B1 (en) 2000-04-28
BR1100309A (en) 2000-08-01
BR9206398A (en) 1994-12-27
JPH07507039A (en) 1995-08-03
CZ40094A3 (en) 1994-11-16
NO314695B1 (en) 2003-05-05
SK282895B6 (en) 2003-01-09
KR100247212B1 (en) 2000-03-15
RU2126014C1 (en) 1999-02-10
ATE172742T1 (en) 1998-11-15
MX9204861A (en) 1994-06-30
AU666673B2 (en) 1996-02-22
ES2124263T3 (en) 1999-02-01
FI940807A (en) 1994-02-21
HUT69178A (en) 1995-08-28
AU2541692A (en) 1993-03-16
CZ293281B6 (en) 2004-03-17
SK20494A3 (en) 1994-10-05
CN1073684A (en) 1993-06-30
PL169562B1 (en) 1996-08-30
NO940592D0 (en) 1994-02-21
DK0605484T3 (en) 1999-07-05
WO1993004081A1 (en) 1993-03-04
NO940592L (en) 1994-04-14
US5776901A (en) 1998-07-07
FI940807A0 (en) 1994-02-21
US5663146A (en) 1997-09-02
FI120095B (en) 2009-06-30
ZA926337B (en) 1993-04-22
HU223664B1 (en) 2004-11-29
NZ244034A (en) 1995-08-28
IL102848A (en) 1998-04-05
DE69227462T2 (en) 1999-04-08
IL102848A0 (en) 1993-01-31
CA2116120A1 (en) 1993-02-23
DE69227462D1 (en) 1998-12-03
HU9400495D0 (en) 1994-05-30
EP0605484A1 (en) 1994-07-13
JP3179489B2 (en) 2001-06-25
CA2116120C (en) 2002-12-03
EP0605484B1 (en) 1998-10-28
RO112507B1 (en) 1997-10-30
FI120691B (en) 2010-01-29
BG98489A (en) 1995-02-28

Similar Documents

Publication Publication Date Title
FI20050467A (en) Methods for promoting growth hormone release in an animal
RU94016393A (en) PEPTIDES possessing the ability to stimulate the growth of the growth hormone, method of production, pharmaceutical composition, method of treatment
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
DK0732101T3 (en) Use of L-deprenyl to delay age-related impairment of mammalian immune system function
KR890700359A (en) Stable interferon complex
MY113488A (en) Compounds with growth hormone releasing properties
DK275585A (en) UNKNOWN CALCIUM SALTS
DE68909409D1 (en) MEDICAL DOSAGE FOR ADMINISTRATION TO FISH.
ES478967A1 (en) 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds
SE503436C2 (en) Pyroglutamidderivat
DK0540676T3 (en) Peptide compounds with growth hormone releasing activity
EP0009636A3 (en) 3-chloro-6-hydroxy-5-methylbenzoic acid derivative, corresponding pharmaceutical preparations, growth promoting compositions, the use of the compounds in the treatment and prophylaxis of diseases and for promoting growth of certain animals, and their manufacture
NO934655D0 (en) Drug for gram-positive diseases in aquatic species
SE7704856L (en) MEANS OF ORAL SUPPLY TO PETS WITHOUT CELLULOSE MELTING IN VAM
DE69220229D1 (en) SOMATOTROPIN FOR INCREASING REPRODUCTIVE PERFORMANCE IN CATTLE
ATE59779T1 (en) METHODS OF REGULATION OF ANIMAL REPRODUCTION.
IT8520712A0 (en) PHARMACEUTICAL FORMULATIONS TO STIMULATE THE RELEASE OF SOMATOTROPIC HORMONE.

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120691

Country of ref document: FI

MM Patent lapsed