ES2155152T3 - Aminometilcromanos sustituidos por benzoisotiazolilo. - Google Patents

Aminometilcromanos sustituidos por benzoisotiazolilo.

Info

Publication number
ES2155152T3
ES2155152T3 ES96109134T ES96109134T ES2155152T3 ES 2155152 T3 ES2155152 T3 ES 2155152T3 ES 96109134 T ES96109134 T ES 96109134T ES 96109134 T ES96109134 T ES 96109134T ES 2155152 T3 ES2155152 T3 ES 2155152T3
Authority
ES
Spain
Prior art keywords
methyl
substituted
amino
benzoisotiazolilo
aminometilcromans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96109134T
Other languages
English (en)
Inventor
Rudolf Schohe-Loop
Hans-Georg Heine
Peter-Rudolf Seidel
Wolfgang Kanhai
Joachim Schuhmacher
Arno Friedl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2155152T3 publication Critical patent/ES2155152T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS AMINO-METIL-CROMANOS BENISOTIAZOLIL SUSTITUIDOS SE OBTIENEN O SUSTITUYENDO EL CORRESPONDIENTE AMINO-METIL-CROMANO INSUSTITUIDO EN EL NITROGENO AMINICO, O HACIENDO REACCIONAR LAS CORRESPONDIENTES BENZISOTIAZOLIL-ALQUIL-AMINAS CON LOS CORRESPONDIENTES METIL-CROMANOS ACTIVADOS, O HACIENDO REACCIONAR EL NITROGENO AMINICO DEL AMINO-METIL-CROMANO PRIMERO CON EL CORRESPONDIENTE ALQUINO SUSTITUIDO Y A CONTINUACION SE HIDROGENA. LOS AMINO-METIL-CROMANOS BENZISOTIAZOLIL SUSTITUIDOS SE PUEDEN UTILIZAR COMO PRINCIPIOS ACTIVOS EN MEDICAMENTOS, EN PARTICULAR EN MEDICAMENTOS PARA EL TRATAMIENTO DE TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL.
ES96109134T 1995-06-19 1996-06-07 Aminometilcromanos sustituidos por benzoisotiazolilo. Expired - Lifetime ES2155152T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19522088A DE19522088A1 (de) 1995-06-19 1995-06-19 Benzisothiazolyl-substituierte Aminomethylchromane

Publications (1)

Publication Number Publication Date
ES2155152T3 true ES2155152T3 (es) 2001-05-01

Family

ID=7764623

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96109134T Expired - Lifetime ES2155152T3 (es) 1995-06-19 1996-06-07 Aminometilcromanos sustituidos por benzoisotiazolilo.

Country Status (21)

Country Link
US (1) US5942529A (es)
EP (1) EP0749970B1 (es)
JP (1) JPH093068A (es)
KR (1) KR970001347A (es)
CN (1) CN1061043C (es)
AR (1) AR003438A1 (es)
AT (1) ATE198749T1 (es)
AU (1) AU706755B2 (es)
CA (1) CA2179205A1 (es)
DE (2) DE19522088A1 (es)
DK (1) DK0749970T3 (es)
ES (1) ES2155152T3 (es)
GR (1) GR3035577T3 (es)
HK (1) HK1003299A1 (es)
HU (1) HUP9601680A3 (es)
IL (1) IL118672A (es)
NO (1) NO306064B1 (es)
NZ (1) NZ286824A (es)
PT (1) PT749970E (es)
SG (1) SG47153A1 (es)
ZA (1) ZA965144B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604191A1 (de) * 1996-02-06 1997-08-07 Hoechst Schering Agrevo Gmbh 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
DE19751949A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
DE19754573A1 (de) * 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
EP1331010A4 (en) * 2000-08-25 2008-08-06 Takeda Pharmaceutical PROPHYLACTIC AGENTS AND REMEDIES AGAINST DISEASES OF THE CENTRAL NERVOUS SYSTEM
DE10058119A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Pepinotan-Kit
DE10101917A1 (de) * 2001-01-16 2002-07-18 Bayer Ag Verwendung von Chromanen
CA2448294A1 (en) * 2001-05-30 2002-12-05 Alteon Inc. Method for treating fibrotic diseases or other indications vi
DE10148425A1 (de) * 2001-10-01 2003-04-17 Bayer Ag Chromane
WO2011001288A2 (en) 2009-06-29 2011-01-06 Bairong Li Metal reduction processes, metallurgical processes and products and apparatus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748182A (en) * 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
GB8810748D0 (en) * 1988-05-06 1988-06-08 Beecham Wuelfing Gmbh & Co Kg Novel treatment
US5300523A (en) * 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
US5510374A (en) * 1990-04-09 1996-04-23 Adir Et Compagnie 3-aminochroman compounds
FR2660657B1 (fr) * 1990-04-09 1993-05-07 Adir Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
DE4140542A1 (de) * 1991-12-09 1993-06-17 Bayer Ag Piperdylmethyl substituierte chormanderivate

Also Published As

Publication number Publication date
ZA965144B (en) 1997-01-23
CN1061043C (zh) 2001-01-24
AR003438A1 (es) 1998-08-05
NO962579D0 (no) 1996-06-18
AU5593896A (en) 1997-01-09
DK0749970T3 (da) 2001-02-05
IL118672A (en) 2000-10-31
US5942529A (en) 1999-08-24
NZ286824A (en) 1998-08-26
NO962579L (no) 1996-12-20
GR3035577T3 (en) 2001-06-29
DE59606332D1 (de) 2001-02-22
CN1143079A (zh) 1997-02-19
CA2179205A1 (en) 1996-12-20
EP0749970B1 (de) 2001-01-17
SG47153A1 (en) 1998-03-20
AU706755B2 (en) 1999-06-24
HUP9601680A2 (hu) 1998-07-28
NO306064B1 (no) 1999-09-13
HUP9601680A3 (en) 1998-08-28
DE19522088A1 (de) 1997-01-02
KR970001347A (ko) 1997-01-24
EP0749970A1 (de) 1996-12-27
PT749970E (pt) 2001-04-30
JPH093068A (ja) 1997-01-07
IL118672A0 (en) 1996-10-16
HK1003299A1 (en) 1998-10-23
ATE198749T1 (de) 2001-02-15
HU9601680D0 (en) 1996-08-28

Similar Documents

Publication Publication Date Title
ES2086623T3 (es) Azaheterociclilmetil-cromanos como principios activos para el tratamiento de enfermedades del sistema nervioso central.
ES2155152T3 (es) Aminometilcromanos sustituidos por benzoisotiazolilo.
ES2097341T3 (es) Indoles sustituidos como farmacos para el tratamiento del sida.
PT97689A (pt) Processo para a preparacao de composicoes farmaceuticas incorporando como ingrediente activo isoxazol-4-carboxilamida e hidroxialquilideno-cianoacetamida
DK1194425T3 (da) Substituerede benzimidazoler
ES2194468T3 (es) Uso de derivados del bisindol indigoide para la fabricacion de un medicamento para inhibir quinasas dependientes de ciclinas.
ES2170141T3 (es) 4-aminoderivados del acido micofenolico con actividad inmunosupresora.
ES2087217T3 (es) Tratamiento de trastornos del sueño mediante el uso de ciertos antidepresivos, como por ejemplo la nefazodona.
MX9308013A (es) 4-fenil-piridonas y 4-fenil-2-fenil-2-alcoxipiridinas sustituidas, procedimiento para su preparacion y medicamentos que los contienen.
SE9701161D0 (sv) New use I
ES2054723T3 (es) Tetrahidropiridinoximas, procedimiento para su preparacion y uso de las mismas como agentes colinergicos.
MX9302487A (es) Piridonas sustituidas por bifenilmetilo, procedimiento para su obtencion y medicamentos que las contienen.
ES2087407T3 (es) Derivados de cromano sustituido con piperidilmetilo como principio activo para el tratamiento de enfermedades del sistema nervioso central.
ES2098316T3 (es) Procedimiento de purificacion de carrageninas comerciales.
ES2153842T3 (es) Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.
BR9406034A (pt) Derivados de imidazoloquinoxalinonas como antagonistas de eaa.
ES2175006T3 (es) N-(pirimidinil)-benzosulfonamidas como medicamentos.
PE20011080A1 (es) Uso de mirtazapina para el tratamiento de trastornos del sueno
ES2054077T3 (es) Utilizacion del aspartato de arginina para la fabricacion de un medicamento para tratar ciertos trastornos de la memoria.
ES2058203T3 (es) Derivados del acido pirocatequincarboxilico, su obtencion y empleo como substancias activas para medicamentos.
ATE167804T1 (de) Verwendung von nickel und bromide ionen für die behandlung von psoriasis
ES2164283T3 (es) Indanilidinacetilguanidinas sustituidas como inhibidores del intercambio de na+/h+, procedimiento para su preparacion, su uso como medicamentos o agentes de diagnostico y medicamentos que las contienen.
ATE285778T1 (de) Topische verabreichung von bestimmten azapriranen zur vorbeugung oder behandlung von hautzuständen, die mit hautzellhyperproliferation und/oder immunologisch vermittelten krankheiten verbunden sind
ES2148600T3 (es) Derivados de indol sustituidos.
MX9306420A (es) Piridonbifenilos sustituidos por alcoximetilo, procedimiento para su obtencion y medicamentos que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 749970

Country of ref document: ES