ES2138969T3 - Combinacion de nucleosidos antivirales. - Google Patents

Combinacion de nucleosidos antivirales.

Info

Publication number
ES2138969T3
ES2138969T3 ES92905707T ES92905707T ES2138969T3 ES 2138969 T3 ES2138969 T3 ES 2138969T3 ES 92905707 T ES92905707 T ES 92905707T ES 92905707 T ES92905707 T ES 92905707T ES 2138969 T3 ES2138969 T3 ES 2138969T3
Authority
ES
Spain
Prior art keywords
combination
antiviral nucleosides
combinations
nucleosides
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905707T
Other languages
English (en)
Inventor
George Robert Painter Iii
Phillip Allen Furman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2138969T3 publication Critical patent/ES2138969T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCUBREN COMBINACIONES SINERGISTICAS DE DERIVADOS DE NUCLEOSIDOS, FORMULACIONES FARMACEUTICAS CONTENIENDO DICHAS COMBINACIONES Y USO DE LAS COMBINACIONES EN EL TRATAMIENTO DE INFECCIONES RETROVIRICAS.
ES92905707T 1991-03-06 1992-03-05 Combinacion de nucleosidos antivirales. Expired - Lifetime ES2138969T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919104740A GB9104740D0 (en) 1991-03-06 1991-03-06 Antiviral nucleoside combination

Publications (1)

Publication Number Publication Date
ES2138969T3 true ES2138969T3 (es) 2000-02-01

Family

ID=10691101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905707T Expired - Lifetime ES2138969T3 (es) 1991-03-06 1992-03-05 Combinacion de nucleosidos antivirales.

Country Status (26)

Country Link
US (2) US5234913A (es)
EP (1) EP0574457B1 (es)
JP (1) JP3442773B2 (es)
KR (1) KR100225986B1 (es)
AT (1) ATE185483T1 (es)
AU (1) AU668860B2 (es)
CA (1) CA2105487C (es)
CZ (1) CZ283185B6 (es)
DE (1) DE69230140T2 (es)
DK (1) DK0574457T3 (es)
ES (1) ES2138969T3 (es)
GB (1) GB9104740D0 (es)
GR (1) GR3032299T3 (es)
HK (1) HK1004189A1 (es)
HU (1) HU219492B (es)
IE (1) IE920702A1 (es)
IL (1) IL101145A (es)
MY (1) MY108638A (es)
NZ (1) NZ241842A (es)
PT (1) PT100199B (es)
RU (1) RU2110993C1 (es)
SK (1) SK279767B6 (es)
TW (1) TW199861B (es)
UA (1) UA29429C2 (es)
WO (1) WO1992015309A1 (es)
ZA (1) ZA921660B (es)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US6346627B1 (en) 1990-02-01 2002-02-12 Emory University Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US6812233B1 (en) * 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
DE69206876T3 (de) * 1991-05-16 2004-08-12 Glaxo Group Ltd., Greenford Nukleosidanalogen enthaltende Antiviren-Zubereitungen
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
AU2119695A (en) * 1994-03-16 1995-10-03 Tanox Biosystems, Inc. Synergistic inhibition of hiv-1 infection using a nucleoside reverse transcriptase inhibitor and anti-hiv-1 antibodies
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
MY115461A (en) 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
DE69636734T2 (de) * 1995-06-07 2007-10-18 Emory University Nucleoside mit anti-hepatitis b virus wirksamkeit
DE69727240T2 (de) * 1996-06-25 2004-11-25 Glaxo Group Ltd., Greenford Kombinationen, enthaltend VX478, Zidovudin und 3TC zur Behandlung von HIV
BR9709951A (pt) * 1996-06-25 1999-08-10 Glaxo Group Ltd Combinação formulação farmacêutica processo de tratamento de uma infecção por hiv em um animal infectado uso de éster de tetraidro-3-furilanila do ácido 3s[3r*(1r,2s*)]-[3-[[4-amino-enil)sulfonil](2-metilpropil]-2-hiroxi-1-fenilmetil)propil]-carbânico, zidovudino,e (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenteno-1-metanol e pacote para paciente
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
CA2287370C (en) * 1997-03-19 2010-02-09 Emory University Synthesis, anti-human immunodeficiency virus and anti-hepatitis b virus activities of 1,3-oxaselenolane nucleosides
EP0986375A2 (en) 1997-04-07 2000-03-22 Triangle Pharmaceuticals Inc. Use of mkc-442 in combination with other antiviral agents
US6040434A (en) * 1997-12-01 2000-03-21 Inaba; Tadanobu Aldehyde oxidase inhibitors for treatment of aids
JP2002518452A (ja) * 1998-06-24 2002-06-25 エモリ ユニバーシティ Ｈｉｖの治療薬物の製造のための他の抗ｈｉｖ薬と組み合わせた３’−アジド−２’，３’−ジデオキシウリジンの使用
AU771779B2 (en) 1998-08-12 2004-04-01 Emory University Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
PT1382343E (pt) 1998-11-02 2010-03-10 Gilead Sciences Inc Terapia de combinação para tratamento do vírus da hepatite b
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
WO2002070518A1 (en) * 2001-03-01 2002-09-12 Triangle Pharmaceuticals, Inc. Polymorphic and other crystalline forms of cis-ftc
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874751A (en) * 1985-03-16 1989-10-17 Burroughs Wellcome Co. Antibacterial treatment
ATE81978T1 (de) * 1985-03-16 1992-11-15 Wellcome Found Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen.
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
JPH07116042B2 (ja) * 1985-05-15 1995-12-13 ザ ウエルカム フアウンデ−シヨン リミテツド ヌクレオシド化合物
NZ222695A (en) * 1986-11-29 1990-03-27 Ueno Seiyaku Oyo Kenkyujo Kk Synergistic antiviral compositions
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
WO1990014079A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1249019B (it) * 1990-06-28 1995-02-11 Lamberti S P A L Emulsione acquosa di resine filmogene per la finitura di pelli, cuoio e croste di pelle e relativo procedimento di applicazione
DE69122264T2 (de) * 1990-11-13 1997-02-06 Biochem Pharma Inc., Laval, Quebec Substituierte 1,3-oxathiolane mit antiviralen eigenschaften
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
DE69206876T3 (de) * 1991-05-16 2004-08-12 Glaxo Group Ltd., Greenford Nukleosidanalogen enthaltende Antiviren-Zubereitungen

Also Published As

Publication number Publication date
IE920702A1 (en) 1992-09-09
CZ183693A3 (en) 1994-06-15
CA2105487C (en) 2002-09-24
HU9302496D0 (en) 1993-11-29
JP3442773B2 (ja) 2003-09-02
TW199861B (es) 1993-02-11
DE69230140D1 (de) 1999-11-18
AU1351292A (en) 1992-10-06
NZ241842A (en) 1994-08-26
JPH06506199A (ja) 1994-07-14
US6107288A (en) 2000-08-22
GB9104740D0 (en) 1991-04-17
SK279767B6 (sk) 1999-03-12
PT100199B (pt) 1999-06-30
UA29429C2 (uk) 2000-11-15
CZ283185B6 (cs) 1998-01-14
US5234913A (en) 1993-08-10
DE69230140T2 (de) 2000-04-06
HUT72460A (en) 1996-04-29
DK0574457T3 (da) 2000-04-17
EP0574457A1 (en) 1993-12-22
ZA921660B (en) 1993-09-06
ATE185483T1 (de) 1999-10-15
IL101145A (en) 1996-08-04
SK95193A3 (en) 1994-01-12
IL101145A0 (en) 1992-11-15
CA2105487A1 (en) 1992-09-07
KR100225986B1 (ko) 1999-10-15
HK1004189A1 (en) 1998-11-20
MY108638A (en) 1996-10-31
EP0574457B1 (en) 1999-10-13
AU668860B2 (en) 1996-05-23
PT100199A (pt) 1993-07-30
HU219492B (hu) 2001-04-28
WO1992015309A1 (en) 1992-09-17
GR3032299T3 (en) 2000-04-27
RU2110993C1 (ru) 1998-05-20

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