ES2135894T3 - Ferrocenos dihalogenados y procedimientos para su preparacion. - Google Patents

Ferrocenos dihalogenados y procedimientos para su preparacion.

Info

Publication number
ES2135894T3
ES2135894T3 ES96911992T ES96911992T ES2135894T3 ES 2135894 T3 ES2135894 T3 ES 2135894T3 ES 96911992 T ES96911992 T ES 96911992T ES 96911992 T ES96911992 T ES 96911992T ES 2135894 T3 ES2135894 T3 ES 2135894T3
Authority
ES
Spain
Prior art keywords
sub
alkyl
formula
puerto
ferrocenildifosfinas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96911992T
Other languages
English (en)
Inventor
Beno T Pugin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2135894T3 publication Critical patent/ES2135894T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
    • B01J31/1625—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts immobilised by covalent linkages, i.e. pendant complexes with optional linking groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/165—Polymer immobilised coordination complexes, e.g. organometallic complexes
    • B01J31/1658—Polymer immobilised coordination complexes, e.g. organometallic complexes immobilised by covalent linkages, i.e. pendant complexes with optional linking groups, e.g. on Wang or Merrifield resins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/189—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms containing both nitrogen and phosphorus as complexing atoms, including e.g. phosphino moieties, in one at least bidentate or bridging ligand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B31/00—Reduction in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
    • C07B35/02—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F112/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F112/02—Monomers containing only one unsaturated aliphatic radical
    • C08F112/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F112/06—Hydrocarbons
    • C08F112/08—Styrene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/842—Iron
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Iron (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Catalysts (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I), EN LA QUE R SUP,1} ES ALQUILO C SUB,1} UB,4} O ALCOXI C SUB,1} DA UNO DE ELLOS INDEPENDIENTMENTE DE LOS OTROS HIDROGENO O ALQUILO C SUB,1} DE FORMULA (I) SON VALIOSOS INTERMEDIOS PARA LOS COMPUESTOS DE FORMULA (III), LOS CUALES SON TAMBIEN OBJETO DE ESTA INVENCION, EN LA QUE R SUB,1}, R SUB,2} Y R SUB,3} Y HAL SON LO DEFINIDO ANTERIORMENTE; R SUB,10} Y R SUB,11} SON IDENTICOS O DIFERENTES Y SON ALQUILO C SUB,1} IDO CON ALQUILO C SUB,1} SUB,4} O FENILO SUSTITUIDO CON UNO A TRES SUSTITUYENTES ALQUILO C SUB,1} SUB,5}R SUB,6}, HALOGENO, SO SUB,3}M, }M, X SUP,-} O FLUOROALQUILO C SUB,1} SUB,10}R SUB,11} ES UN RADICAL DE FORMULA (IV, IVA, IVB O IVC); R SUB,4}, R SUB,5} Y R SUB,6} SON CADA UNO DE ELLOS INDEPENDIENTEMENTE DE LOS OTROS ALQUILO C SUB,1} R SUB,7} Y R SUB,8} SON H, ALQUILO C SUB,1} LO O R SUB,7} Y R SUB,8} SON JUNTOS TETRAMETILENO, PENTAMETILENO O 3 DE UN ACIDO MONOBASICO. LOS COMPUESTOS DE FORMULA (III) SON POR SI MISMOS IMPORTANTES INTERMEDIOS PARA LAS FERROCENILDIFOSFINAS SILILADAS Y SUS COMPLEJOS METALICOS. LAS FERROCENILDIFOSFINAS QUE CONTIENEN UN RADICAL ORGANICO UNIDO MEDIANTE UN GRUPO SILENO A UN ANILLO CICLOPENTADIENILO SE PUEDEN INMOVILIZAR DE FORMA SIMPLE TANTO SOBRE SOPORTES INORGANICOS COMO SOBRE SOPORTES ORGANICOS POLIMERICOS O, DESPUES DE LA INTRODUCCION DE UN GRUPO POLIMERIZABLE, SE PUEDEN INMOVILIZAR TAMBIEN POR COPOLIMERIZACION. CON RODIO E IRIDIO LOS LIGANDOS INMOVILIZDOS DE FERROCENILDIFOSFINA FORMAN COMPLEJOS QUE SE PUEDEN UTILIZAR COMO CATALIZADORES ALTAMENTE ACTIVOS EN LA HIDROGENACION ENANTIOSELECTIVA DE DOBLES ENLACES CARBONO-CARBONO, CARBONONITROGENO O CARBONO-OXIGENO.
ES96911992T 1995-04-11 1996-04-02 Ferrocenos dihalogenados y procedimientos para su preparacion. Expired - Lifetime ES2135894T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH106795 1995-04-11

Publications (1)

Publication Number Publication Date
ES2135894T3 true ES2135894T3 (es) 1999-11-01

Family

ID=4201677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96911992T Expired - Lifetime ES2135894T3 (es) 1995-04-11 1996-04-02 Ferrocenos dihalogenados y procedimientos para su preparacion.

Country Status (14)

Country Link
US (2) US5925778A (es)
EP (1) EP0820460B1 (es)
JP (1) JP3854638B2 (es)
KR (1) KR100416359B1 (es)
AT (1) ATE182595T1 (es)
AU (1) AU5499296A (es)
BR (1) BR9608128A (es)
CA (1) CA2216153C (es)
CZ (1) CZ291280B6 (es)
DE (1) DE69603466T2 (es)
ES (1) ES2135894T3 (es)
HU (1) HU221611B (es)
PL (1) PL322745A1 (es)
WO (1) WO1996032400A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2135894T3 (es) * 1995-04-11 1999-11-01 Novartis Ag Ferrocenos dihalogenados y procedimientos para su preparacion.
ATE212032T1 (de) 1996-07-10 2002-02-15 Syngenta Participations Ag Funktionalisierte ferrocenyldiphospine, verfahren zu ihrer herstellung und ihre verwendung
CA2263715C (en) * 1996-10-07 2007-05-01 Novartis Ag Chiral ferrocenyls
DE19952348A1 (de) * 1998-12-19 2000-06-21 Degussa Liganden und Komplexe zur enantioselektiven Hydrierung
US6378830B1 (en) * 2000-10-05 2002-04-30 Lu Sheng-Nan Adjustable support for an LCD monitor
US6620954B1 (en) * 2002-03-25 2003-09-16 Eastman Chemical Company Phosphinometallocenylamides as novel ligands for asymmetric catalysis
JP4218261B2 (ja) * 2002-06-11 2009-02-04 ダイキン工業株式会社 ポンプユニット
GB0228018D0 (en) * 2002-11-30 2003-01-08 Lucite Int Uk Ltd Carbonylation of ester
EP1554039B1 (en) * 2002-09-12 2013-07-03 Lucite International UK Limited A catalyst system comprising a 1,2-bis-(phosphino)metallocene ligand
KR20060038961A (ko) 2003-07-03 2006-05-04 루사이트 인터내셔널 유케이 리미티드 에틸렌으로 불포화된 화합물의 하이드로포르밀화 방법
GB0400720D0 (en) * 2004-01-14 2004-02-18 Stylacats Ltd Novel ferrocene-based phosphorus chiral phosphines
GB0403592D0 (en) 2004-02-18 2004-03-24 Lucite Int Uk Ltd A catalyst system
GB0411951D0 (en) * 2004-05-28 2004-06-30 Lucite Int Uk Ltd Carbonylation of ester
GB0504851D0 (en) * 2005-03-09 2005-04-13 E2V Tech Uk Ltd Biosensor labelling groups
GB0516556D0 (en) * 2005-08-12 2005-09-21 Lucite Int Uk Ltd Improved catalyst system
CA2626107C (en) 2005-11-17 2016-06-21 Lucite International Uk Limited Carbonylation of ethylenically unsaturated compounds
GB0607494D0 (en) 2006-04-13 2006-05-24 Lucite Int Uk Ltd Metal complexes
CN105153241B (zh) * 2006-12-02 2020-05-15 卢西特国际英国有限公司 羰基化配体及其在羰基化烯键式不饱和化合物中的用途
GB0625518D0 (en) * 2006-12-21 2007-01-31 Lucite Int Uk Ltd Carbonylation of conjugated dienes
GB0812297D0 (en) * 2008-07-04 2008-08-13 Lucite Int Uk Ltd Novel carbonylation ligand sand thier use of in the carbonylation of ethylenically unsaturated compounds
JP5493346B2 (ja) * 2008-12-11 2014-05-14 東ソー株式会社 フェロセン誘導体およびその用途
GB0905995D0 (en) * 2009-04-06 2009-05-20 Univ Gent Cyclic imidate ligands
GB201000078D0 (en) 2010-01-05 2010-02-17 Lucite Int Uk Ltd Process for the carbonylation of ethylenically unsaturated compounds, novel carbonylation ligands and catalyst systems incorporatng such ligands
GB201211157D0 (en) * 2012-06-22 2012-08-08 Atlas Genetics Ltd Novel compounds and their use in analytical methods
JP2023130917A (ja) * 2022-03-08 2023-09-21 国立大学法人 東京大学 コア／シェル型不均一系触媒およびそれを用いた光学活性化合物の製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG43803A1 (en) * 1991-01-25 1997-11-14 Ciba Geigy Ag Diphosphines containing silane groups immobilised diphosphines and the use thereof as hydrogenation catalyst
EP0496699B1 (de) * 1991-01-25 1995-04-26 Ciba-Geigy Ag Silangruppen enthaltende Diphosphine, immobilisierte Diphosphine und deren Verwendung als Hydrierkatalysatoren
EP0564406B1 (de) * 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
EP0612758B1 (de) * 1993-02-26 2003-04-09 Syngenta Participations AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
EP0646590B1 (de) * 1993-10-01 1999-08-25 Novartis AG Mit Fluoralkyl substituierte Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
AU4257396A (en) * 1994-11-29 1996-06-19 Lonza A.G. Method of producing optically active metallocenyl phosphines
EP0729969B1 (de) * 1995-02-24 2000-08-16 Novartis AG Silylierte Ferrocenyldiphosphine, an anorganische oder polymere organische Träger gebundene silylierte Ferrocenyldiphosphine sowie Metallkomplexe davon, ihre Herstellung und Verwendung
ES2135894T3 (es) * 1995-04-11 1999-11-01 Novartis Ag Ferrocenos dihalogenados y procedimientos para su preparacion.
HRP960295A2 (en) * 1995-07-06 1997-08-31 Ciba Geigy Ag Process for the hydrogenation of imines in the presence of immobilized iridium-diphosphine catalysts

Also Published As

Publication number Publication date
CA2216153A1 (en) 1996-10-17
CZ320397A3 (cs) 1998-02-18
US5925778A (en) 1999-07-20
DE69603466D1 (de) 1999-09-02
DE69603466T2 (de) 1999-11-18
PL322745A1 (en) 1998-02-16
KR19980703784A (ko) 1998-12-05
US6015919A (en) 2000-01-18
EP0820460A1 (en) 1998-01-28
HUP9801601A2 (hu) 1998-10-28
HU221611B (hu) 2002-11-28
CA2216153C (en) 2008-02-05
ATE182595T1 (de) 1999-08-15
HUP9801601A3 (en) 1999-03-29
AU5499296A (en) 1996-10-30
EP0820460B1 (en) 1999-07-28
BR9608128A (pt) 1999-02-09
WO1996032400A1 (en) 1996-10-17
CZ291280B6 (cs) 2003-01-15
JP3854638B2 (ja) 2006-12-06
KR100416359B1 (ko) 2004-04-21
JPH11503439A (ja) 1999-03-26

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