ES2062374T3 - Heteroarilpiperazinas, agentes antipsicoticos. - Google Patents

Heteroarilpiperazinas, agentes antipsicoticos.

Info

Publication number
ES2062374T3
ES2062374T3 ES90307166T ES90307166T ES2062374T3 ES 2062374 T3 ES2062374 T3 ES 2062374T3 ES 90307166 T ES90307166 T ES 90307166T ES 90307166 T ES90307166 T ES 90307166T ES 2062374 T3 ES2062374 T3 ES 2062374T3
Authority
ES
Spain
Prior art keywords
heteroarilpiperazinas
antipsychotic agents
compounds
antipsychotic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90307166T
Other languages
English (en)
Inventor
Harry R Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2062374T3 publication Critical patent/ES2062374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Gas Separation By Absorption (AREA)
  • Treating Waste Gases (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FORMULA FIG Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, EN DONDE R1, Z, X, W E Y SON COMO SE DEFINE MAS ADELANTE. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA PSICOSIS Y LA ANSIEDAD.
ES90307166T 1989-07-07 1990-06-29 Heteroarilpiperazinas, agentes antipsicoticos. Expired - Lifetime ES2062374T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/002954 WO1991000863A1 (en) 1989-07-07 1989-07-07 Heteroaryl piperazine antipsychotic agents

Publications (1)

Publication Number Publication Date
ES2062374T3 true ES2062374T3 (es) 1994-12-16

Family

ID=22215102

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90307166T Expired - Lifetime ES2062374T3 (es) 1989-07-07 1990-06-29 Heteroarilpiperazinas, agentes antipsicoticos.

Country Status (11)

Country Link
EP (1) EP0409435B1 (es)
JP (1) JPH0717633B2 (es)
AT (1) ATE113282T1 (es)
CA (1) CA2020611A1 (es)
DE (1) DE69013601T2 (es)
DK (1) DK0409435T3 (es)
ES (1) ES2062374T3 (es)
FI (1) FI920023A0 (es)
IE (1) IE63134B1 (es)
PT (1) PT94608A (es)
WO (1) WO1991000863A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
WO2004026864A1 (en) * 2002-09-17 2004-04-01 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
EP1546145A1 (en) * 2002-09-26 2005-06-29 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
GEP20115364B (en) 2005-05-10 2011-12-26 Intermune Inc Method for modulation of stress-activated protein kinase system
AR055203A1 (es) 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
WO2008037681A1 (en) 2006-09-26 2008-04-03 Glaxo Group Limited 5-{2-[4-(2-methyl-5-quinolinyl)-l-piperidinyl] ethyl} quinolinone derivatives as 5ht1a receptor modulators for treating sexual dysfunction, cognition impairement, psychotic disorders, anxiety, depression, etc.
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
NZ597108A (en) * 2009-06-25 2014-04-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
HRP20240285T1 (hr) 2011-03-18 2024-05-24 Alkermes Pharma Ireland Limited Farmaceutski pripravci koji sadrže sorbitan estere
CA2858787C (en) 2011-12-15 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of tertiary amine compounds
WO2013142205A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
WO2013142202A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
US10004807B2 (en) 2012-03-19 2018-06-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
EP3119399A4 (en) 2014-03-20 2017-09-27 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン（又はピペラジン）誘導体及びその統合失調症治療のための使用
MX2016012808A (es) 2014-04-02 2017-01-05 Intermune Inc Piridinonas anti-fibroticas.
AU2019230014A1 (en) 2018-03-05 2020-09-17 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity

Also Published As

Publication number Publication date
DK0409435T3 (da) 1994-11-21
IE63134B1 (en) 1995-03-22
CA2020611A1 (en) 1991-01-08
EP0409435B1 (en) 1994-10-26
DE69013601T2 (de) 1995-03-02
JPH0717633B2 (ja) 1995-03-01
DE69013601D1 (de) 1994-12-01
IE902450A1 (en) 1991-02-13
FI920023A0 (fi) 1992-01-03
JPH0344388A (ja) 1991-02-26
EP0409435A1 (en) 1991-01-23
PT94608A (pt) 1991-03-20
WO1991000863A1 (en) 1991-01-24
ATE113282T1 (de) 1994-11-15

Similar Documents

Publication Publication Date Title
ES2062374T3 (es) Heteroarilpiperazinas, agentes antipsicoticos.
ATE168992T1 (de) 7-substituierte-9-substituierte glycylamido-6- demethyl-6-deoxytetracycline
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
ES2058614T3 (es) 1,2-ciclohexilaminoarilaminadas utiles como agentes analgesicos.
ATE215530T1 (de) 7-substituierte-8-substituierte-9-substituierte amino-7-demethyl-6-deoxy-tetracycline als antibiotische mittel
MX9304646A (es) Nuevas 7-(sustituido)-8-(sustituido)d-9-[(glicilo sustituido)amido]-6-desmetil-6-desoxitetraciclinasy metodo para su produccion.
PH30006A (en) 9-¬(Substituted glycol)amido¾-6.demethyl-6-deoxytetra-cyclines
PT618190E (pt) 9-¬glicil substituido)amido|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas
PT882726E (pt) Carbazol-carboxamidas como agonistas 5-ht1f
FI881609A (fi) Dihydropyridinamider, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
ATE118209T1 (de) Pyridin-3-percarboxylsäure monopersulfat.
FI932691A (fi) Nya benzyl- och benzhydrylalkoholer
DE69222143D1 (de) Indanderivate
DK0381114T3 (da) Exo-3,4-O-benzyliden-3"-demethylchartreusin og salte deraf
GR3020597T3 (en) Phospholipids for the treatment of multiple sclerosis
ES2066147T3 (es) Derivados de la 1,4-dihidro-4-oxo-3-quinolina como agentes antibacterianos en mamiferos selectivamente toxicos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 409435

Country of ref document: ES