ES2058118T3 - Derivados heterociclicos de propeno amida, procedimiento para su preparacion y su uso como farmacos. - Google Patents

Derivados heterociclicos de propeno amida, procedimiento para su preparacion y su uso como farmacos.

Info

Publication number
ES2058118T3
ES2058118T3 ES87306989T ES87306989T ES2058118T3 ES 2058118 T3 ES2058118 T3 ES 2058118T3 ES 87306989 T ES87306989 T ES 87306989T ES 87306989 T ES87306989 T ES 87306989T ES 2058118 T3 ES2058118 T3 ES 2058118T3
Authority
ES
Spain
Prior art keywords
alkyl
halo
substituted
hydrogen
pharmacs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87306989T
Other languages
English (en)
Inventor
Peter Thaddeus Gallagher
Terence Alan Hicks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of ES2058118T3 publication Critical patent/ES2058118T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE X ES R''(OH)C=C(CN)-, R1(CO)-CH(CN)- O EL GRUPO (II), SIENDO R1 Y R2 HIDROGENO O UN ALQUILO DE 1 A 6 C, R3,R4,R5 Y R6 SON CADA UNO HIDROGENO, HIDROXI, HALOGENO, NITRO, CIANO, CARBOXI, ALQUILO, ALCOXI, ALQUILTIO Y ALQUILO HALO SUSTITUIDO DE 1 A 4 C, ALCOXICARBONILO DE 2 A 5 C FENILO O FENOXI OPCIONALMENTE SUSTITUIDOS, R''R"N- (DONDE R'' Y R" SON CADA UNO HIDROGENO O ALQUILO DE 1 A 4 C), R"''CONH- (SIENDO R"'' ALQUILO DE 1 A 4 C) O UN GRUPO DE FORMULA -CR7R8R9 (EN EL QUE R7, R8 Y R9 SON CADA UNO ALQUILO O HALOALQUILO DE 1 A 6 C O FENILO QUE PUEDE ESTAR SUSTITUIDO, O BIEN R7 Y R8 EN UNION DEL ATOMO DE CARBONO AL QUE ESTAN UNIDOS, FORMAN UN GRUPO CICLOALQUILO QUE CONTIENE DE 3 A 7 ATOMOS DE CARBONO, O R7, R8 Y R9 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN GRUPO BICICLOALQUILICO QUE CONTIENE DE 4 A 9 ATOMOS DE CARBONO), E Y ES UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS, EXCLUYENDO EL PIRAZOL. TANTO LOS COMPUESTOS DE LAINVENCION COMO SUS SALES TIENEN PROPIEDADES FARMACEUTICAS.
ES87306989T 1986-08-08 1987-08-06 Derivados heterociclicos de propeno amida, procedimiento para su preparacion y su uso como farmacos. Expired - Lifetime ES2058118T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619433A GB8619433D0 (en) 1986-08-08 1986-08-08 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ES2058118T3 true ES2058118T3 (es) 1994-11-01

Family

ID=10602474

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87306989T Expired - Lifetime ES2058118T3 (es) 1986-08-08 1987-08-06 Derivados heterociclicos de propeno amida, procedimiento para su preparacion y su uso como farmacos.

Country Status (20)

Country Link
US (1) US4983619A (es)
EP (1) EP0259972B1 (es)
JP (1) JPS63246364A (es)
CN (1) CN1021050C (es)
AT (1) ATE91489T1 (es)
AU (1) AU605498B2 (es)
CA (1) CA1290335C (es)
DE (1) DE3786507T2 (es)
DK (1) DK414087A (es)
EG (1) EG18231A (es)
ES (1) ES2058118T3 (es)
GB (1) GB8619433D0 (es)
HU (1) HU204520B (es)
IL (1) IL83433A (es)
MX (1) MX173324B (es)
NZ (1) NZ221353A (es)
PH (1) PH23488A (es)
PT (1) PT85477B (es)
SU (1) SU1593568A3 (es)
ZA (1) ZA875812B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
CA2083179C (en) * 1990-05-18 2001-10-23 Robert Ryder Bartlett Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
JPH06135948A (ja) * 1992-10-30 1994-05-17 Taiho Yakuhin Kogyo Kk スチレン誘導体又はその塩
WO1995024894A2 (en) * 1994-03-14 1995-09-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
US20160287549A1 (en) 2013-11-22 2016-10-06 Genzyme Corporation Novel methods for treating neurodegenerative diseases
WO2021050556A1 (en) * 2019-09-09 2021-03-18 Rutgers, The State University Of New Jersey Compositions and methods for inhibiting ribosome inactivating proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DK545976A (da) * 1975-12-11 1977-06-12 Hoechst Ag Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
GB1598900A (en) * 1978-05-23 1981-09-23 Lilly Industries Ltd Heterocyclic amino derivatives
EP0021207B1 (de) * 1979-06-11 1985-08-07 Ciba-Geigy Ag Alphacarbamoyl-pyrrolpropionitrile, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate die diese Verbindungen enthalten
DE3331874A1 (de) * 1982-09-13 1984-04-05 Sandoz-Patent-GmbH, 7850 Lörrach Neue thiophenderivate
DE3609542A1 (de) * 1986-03-21 1987-10-01 Bayer Ag 5-acylamino-pyrazol-derivate

Also Published As

Publication number Publication date
US4983619A (en) 1991-01-08
NZ221353A (en) 1990-04-26
CN87105515A (zh) 1988-03-23
IL83433A0 (en) 1988-01-31
EG18231A (en) 1992-10-30
PT85477A (en) 1987-09-01
SU1593568A3 (ru) 1990-09-15
ATE91489T1 (de) 1993-07-15
PT85477B (pt) 1990-06-29
IL83433A (en) 1992-03-29
ZA875812B (en) 1989-04-26
EP0259972A2 (en) 1988-03-16
DE3786507T2 (de) 1993-11-11
DE3786507D1 (de) 1993-08-19
MX7667A (es) 1993-09-01
CN1021050C (zh) 1993-06-02
HU204520B (en) 1992-01-28
MX173324B (es) 1994-02-16
GB8619433D0 (en) 1986-09-17
AU7668087A (en) 1988-02-11
PH23488A (en) 1989-08-16
DK414087D0 (da) 1987-08-07
JPS63246364A (ja) 1988-10-13
CA1290335C (en) 1991-10-08
AU605498B2 (en) 1991-01-17
EP0259972B1 (en) 1993-07-14
DK414087A (da) 1988-02-09
EP0259972A3 (en) 1990-05-02
HUT46684A (en) 1988-11-28

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