DE68914793D1 - Chinazolinon-Derivate. - Google Patents

Chinazolinon-Derivate.

Info

Publication number
DE68914793D1
DE68914793D1 DE68914793T DE68914793T DE68914793D1 DE 68914793 D1 DE68914793 D1 DE 68914793D1 DE 68914793 T DE68914793 T DE 68914793T DE 68914793 T DE68914793 T DE 68914793T DE 68914793 D1 DE68914793 D1 DE 68914793D1
Authority
DE
Germany
Prior art keywords
4alkyl
hydrogen
substituted
6alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68914793T
Other languages
English (en)
Other versions
DE68914793T2 (de
Inventor
William John Coates
Lawrence Ivan Kruse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of DE68914793D1 publication Critical patent/DE68914793D1/de
Application granted granted Critical
Publication of DE68914793T2 publication Critical patent/DE68914793T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
DE68914793T 1988-11-30 1989-11-27 Chinazolinon-Derivate. Expired - Fee Related DE68914793T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827988A GB8827988D0 (en) 1988-11-30 1988-11-30 Chemical compounds

Publications (2)

Publication Number Publication Date
DE68914793D1 true DE68914793D1 (de) 1994-05-26
DE68914793T2 DE68914793T2 (de) 1994-08-18

Family

ID=10647738

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914793T Expired - Fee Related DE68914793T2 (de) 1988-11-30 1989-11-27 Chinazolinon-Derivate.

Country Status (11)

Country Link
US (1) US5147875A (de)
EP (1) EP0371731B1 (de)
JP (1) JPH02193983A (de)
AT (1) ATE104665T1 (de)
AU (1) AU630638B2 (de)
CA (1) CA2003690A1 (de)
DE (1) DE68914793T2 (de)
DK (1) DK602589A (de)
GB (1) GB8827988D0 (de)
PT (1) PT92437B (de)
ZA (1) ZA899101B (de)

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US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
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US7208516B2 (en) * 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
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EP1538913A2 (de) * 2002-04-12 2005-06-15 Celgene Corporation Modulation von stamm- und vorläuferzelldifferenzierung, analysen und verwendungen davon
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Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3169129A (en) * 1963-05-10 1965-02-09 American Cyanamid Co 2-ortho-hydroxy-phenyl-4-(3h)-quinazolinones
USRE26565E (en) * 1966-03-02 1969-04-29 Table iii
US3526627A (en) * 1969-06-05 1970-09-01 American Cyanamid Co Method for preparation of quinazolones
US3651061A (en) * 1970-04-20 1972-03-21 Ernst Reif 2 3-dihydro-2-(1-naphthyl)-4(1h)quinazolinone and the 6-chloroanalog
JPS604831B2 (ja) * 1975-10-20 1985-02-06 中外製薬株式会社 4(3h)−キナゾリノン誘導体の製法
IT1050750B (it) * 1975-12-05 1981-03-20 Erba Carlo Spa Derivati della 3.4 di idro chinazolina
US4159330A (en) * 1976-11-02 1979-06-26 Carlo Erba S.P.A. 2-Disubstituted phenyl-3,4-dihydro-4-oxo-quinazoline derivatives and process for their preparation
US4431440A (en) * 1981-02-20 1984-02-14 American Cyanamid Company Method to alter or control the development and/or the life cycle of various plant species

Also Published As

Publication number Publication date
ZA899101B (en) 1990-09-26
PT92437A (pt) 1990-05-31
DK602589D0 (da) 1989-11-29
AU4541689A (en) 1990-06-07
CA2003690A1 (en) 1990-05-31
DK602589A (da) 1990-05-31
AU630638B2 (en) 1992-11-05
EP0371731B1 (de) 1994-04-20
DE68914793T2 (de) 1994-08-18
EP0371731A2 (de) 1990-06-06
JPH02193983A (ja) 1990-07-31
ATE104665T1 (de) 1994-05-15
GB8827988D0 (en) 1989-01-05
PT92437B (pt) 1995-08-09
US5147875A (en) 1992-09-15
EP0371731A3 (de) 1991-01-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee