EP4297733A1 - Compositions pharmaceutiques à dose fixe - Google Patents

Compositions pharmaceutiques à dose fixe

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Publication number
EP4297733A1
EP4297733A1 EP22707862.3A EP22707862A EP4297733A1 EP 4297733 A1 EP4297733 A1 EP 4297733A1 EP 22707862 A EP22707862 A EP 22707862A EP 4297733 A1 EP4297733 A1 EP 4297733A1
Authority
EP
European Patent Office
Prior art keywords
rivaroxaban
amlodipine
fixed
dosage form
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22707862.3A
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German (de)
English (en)
Inventor
Marc THEURER
Mario STEIGERWALD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Filing date
Publication date
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Publication of EP4297733A1 publication Critical patent/EP4297733A1/fr
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Definitions

  • This invention relates to fixed-dose pharmaceutical compositions comprising an anticoagulant compound, an antihypertensive compound and a pharmaceutically acceptable excipient, and the use of the compositions for the treatment and prevention of stroke and systemic embolism, and for the treatment and prevention of stroke and systemic embolism in patients with essential hypertension.
  • Ischemic strokes are caused by reduced blood supply to the brain. Among other things, the reduction in blood supply reduces the amount of oxygen supplied to brain tissue, which in turn leads to cellular dysfunction and cell death.
  • Hemorrhagic strokes are caused by intracerebral or subarachnoid hemorrhage.
  • An intracerebral hemorrhage occurs when an artery in the brain bursts, which causes a bleed within the brain.
  • a subarachnoid hemorrhage occurs when a bleed occurs outside of the confines of the brain, but within those of the skull. As with ischemic stroke, these bleeding events cause reduced blood and oxygen supply to the brain tissue.
  • ischemic stroke Two of the most common causes of ischemic stroke are thrombosis and systemic embolism.
  • a thrombosis is the formation of a blood clot (thrombus) within a blood vessel.
  • the blood clot obstructs the artery in which it is lodged, and reduces the ability of the artery supply the normal amount of blood to surrounding tissue.
  • Ischemic stroke occurs when a blood clot blocks a blood vessel, typically an artery, close to or in the brain.
  • An embolism occurs when an embolus, which is frequently a part of a thrombus (but can also be a fat globule, air or gas or any other exogenous matter), blocks a blood vessel. Similarly to a thrombus, an embolus obstructs blood flow in a blood vessel, and causes a total or partial blockage. However, unlike when a thrombus causes an ischemic stroke (by blocking a vessel close to or in the brain), an embolus causes a blockage in a systemic blood vessel that is comparatively distant from the brain, located elsewhere in the body.
  • Hypertension is a long-term medical condition where the blood pressure in the arteries is consistently elevated. Hypertension alone does not necessarily present symptoms, however long-term blood pressure is known to be a risk factor and contributor to cardiac problems, including heart failure and coronary artery disease, as well as stroke and dementia. Hypertension is categorised as either primary (essential) or secondary hypertension. The vast majority of cases (85% >) present as essential hypertension. Essential hypertension has no known secondary cause, and its prevalence is linked to genetic predisposition and environmental factors. It is defined when blood pressure is consistently 140/90 mmHg or above.
  • the causative factors of ischemic and stroke and systemic embolism are the formation of blood clots and hypertension, and a causative factor of hemorrhagic stroke is hypertension.
  • the medical profession have focused their attention on stroke prevention by recommending people seek to implement a combination of a healthy diet and regular exercise into their daily lifestyle. The avoidance of smoking and drinking too much alcohol is also recommended.
  • the pathological effect of adhering to this advice is that the risk of high blood pressure and high cholesterol levels are reduced, which in turn reduces the risks of ischemic and hemorrhagic stroke.
  • Anticoagulants prevent blood clots by interfering with the coagulation cascade. Such interference alters the chemical composition of the blood in a way that prevents clot formation by “thinning” the blood.
  • anticoagulants for example warfarin, apixaban, dabigatran, edoxaban and rivaroxaban for the prevention of further stroke episodes is well established in the art (see J Saraiva Cardiol Ther 2018, 7, 15-24).
  • Anticoagulants may also be prescribed to prevent a first stroke in patients who are particularly at risk, for example those suffering from atrial fibrillation (see Sherzai and Elkind Ann N Y Acad Sci 2015, 1- 15).
  • an antihypertensive may be prescribed to lower blood pressure, and thus reduce the risk of a first or subsequent stroke.
  • the invention provides a fixed-dose pharmaceutical composition comprising:
  • the invention also provides the fixed-dose pharmaceutical composition for use in the treatment or prevention of stroke and systemic embolism, or for use in the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism, or a method for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension comprising administering to a human the fixed-dose pharmaceutical composition.
  • the invention also provides the use of the fixed-dose pharmaceutical composition for the treatment or prevention of stroke and systemic embolism, or for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • a fixed-dose pharmaceutical composition comprising an anticoagulant and an antihypertensive may treat and prevent stroke and systemic embolism in patients with and without essential hypertension with improved efficacy compared to the use of either agent alone, or the use of both agents administered according to independent dosage regimens, i.e. not a fixed-dose composition.
  • a fixed-dose composition is a viable formulation approach for the active ingredients rivaroxaban and amlodipine. This finding was surprising because the Tmax (time to maximum plasma concentration) of rivaroxaban is 2 to 4 hours, whereas the Tmax for amlodipine is 6 to 12 hours.
  • active ingredients with different pharmacokinetic profiles i.e. differing Tmax
  • Tmax pharmacokinetic profiles
  • Fig. 1 shows the percentage dissolution (release) of rivaroxaban in pH 4.5 acetate buffer & 0.4% SLS 900 ml_, 75 rpm @ 37°C with paddle from Xarelto and T/061 D
  • Fig. 2 shows the percentage dissolution (release) of amlodipine in 0.01 N HCI, 900 ml_, 50 rpm @ 37°C with paddle from Istin, T/061 D and T/097D;
  • Fig. 3 shows the percentage dissolution (release) of rivaroxaban in pH 4.5 acetate buffer & 0.4% SLS 900 mL, 75 rpm @ 37°C with paddle from Xarelto and T/067D;
  • Fig. 4 shows the percentage dissolution (release) of amlodipine in 0.01 N HCI, 900 mL, 50 rpm @ 37°C with paddle from Istin and T/067D
  • Fig. 5 shows the percentage dissolution (release) of rivaroxaban in pH 4.5 acetate buffer & 0.4% SLS 900 ml_, 75 rpm @ 37°C with paddle from Xarelto, T/066D and T/073D;
  • Fig. 6 shows the percentage dissolution (release) of amlodipine in 0.01 N HCI, 900 ml_, 50 rpm @ 37°C with paddle from Istin, T/066D and T/099D;
  • Fig. 7 shows the percentage dissolution (release) of rivaroxaban in pH 4.5 acetate buffer & 0.4% SLS 900 mL, 75 rpm @ 37°C with paddle from Xarelto and T/071 D;
  • Fig. 8 shows the percentage dissolution (release) of amlodipine in 0.01 N HCI, 900 mL, 50 rpm @ 37°C with paddle from Istin and T/071 D;
  • Fig. 9 shows the percentage dissolution (release) of rivaroxaban in pH 4.5 acetate buffer & 0.4% SLS 900 mL, 75 rpm @ 37°C with paddle from Xarelto, T/080D, T/085D, T/089D, T/095D and T/096D; and
  • Fig. 10 shows the percentage dissolution (release) of amlodipine in 0.01 N HCI, 900 mL, 50 rpm @ 37°C with paddle from Istin and T/080D, T/089D, T/091 D, T/095D and T/096D.
  • the proportions of the various components of the compositions are defined relative to other components.
  • the amount of various components of the compositions are listed in milligrams (mg). If an amount of active ingredient is provided in mg, the amount refers to the amount of free base of the compound.
  • treatment in the context of treating a condition i.e. state, disorder or disease, pertains generally to treatment and therapy, whether for a human or an animal (e.g. in veterinary applications), in which some desired therapeutic effect is achieved, for example, the inhibition of the progress of the condition, and includes a reduction in the rate of progress, a halt in the rate of progress, amelioration of the condition, diminishment or alleviation of at least one symptom associated or caused by the condition being treated and cure of the condition.
  • treatment can be diminishment of one or several symptoms of a disorder or complete eradication of a disorder.
  • prevention i.e. use of a compound as prophylactic measure
  • a condition i.e. state, disorder or disease
  • prevention pertains generally to the prophylaxis or prevention, whether for a human or an animal (e.g. in veterinary applications), in which some desired preventative effect is achieved, for example, in preventing occurrence of a disease or guarding from a disease.
  • Prophylaxis includes complete and total blocking of all symptoms of a disorder for an indefinite period of time, the mere slowing of the onset of one or several symptoms of the disease, or making the disease less likely to occur.
  • the term “fixed-dose composition” as used herein means a single dosage form that contains a combination of two or more active ingredients. For example, a single tablet or capsule which contains two active ingredients.
  • the invention provides a fixed-dose pharmaceutical composition comprising:
  • Rivaroxaban and apixaban are anticoagulants that prevent blood clots by interfering with the coagulation cascade. Such interference alters the chemical composition of the blood in a way that prevents clot formation by “thinning” the blood.
  • the anticoagulant is present at from 1 to 25 mg, and in particular from 2 to 20 mg e.g. 2.5 mg, 5 mg, 10 mg, 12.5 mg, 15 mg, 17.5 mg or 20 mg.
  • Rivaroxaban is an anticoagulant which binds directly and reversibly to factor Xa. It is marketed in a number of countries as Xarelto®, as an oral anticoagulant. It is indicated for the treatment of various thromboembolic diseases, including for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hip replacement or total knee replacement surgery; and for the prophylaxis of stroke and systemic embolism in patients with non-valvular atrial fibrillation and with at least one risk factor selected from: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age > 75 years, or diabetes mellitus (also see, WO 01/47919 (the basic patent), WO 2004/060887 and WO 2007/039132).
  • VTE venous thromboembolic events
  • Rivaroxaban has the chemical name 5-chloro-N- ⁇ [(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1 ,3- oxazolidin-5-yl]methyl ⁇ thiophene-2-carboxamide, and has the following structure:
  • Rivaroxaban can be synthesised according to one or more methods known in the art, see for example WO 2004/060887, WO 2015/198259 and G. Yu., et. al., Organic Preparations and Procedures International 2017, 49, 169-177.
  • the fixed-dose pharmaceutical composition includes rivaroxaban, an antihypertensive selected from amlodipine, torasemide, bisoprolol or metoprolol, and a pharmaceutically acceptable excipient.
  • the composition includes from 5 mg to 20 mg of rivaroxaban, in particular 10 mg to 20 mg e.g. 10 mg, 15 mg or 20 mg.
  • rivaroxaban in particular 10 mg to 20 mg e.g. 10 mg, 15 mg or 20 mg.
  • Apixaban is an anticoagulant which binds directly and reversibly to factorXa. It is marketed in a number of countries as Eliquis®, as an oral anticoagulant. It is indicated for the treatment of various thromboembolic diseases, including for the prophylaxis of stroke and systemic embolism in patients with non-valvular atrial fibrillation and with at least one risk factor selected from: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age > 75 years, or diabetes mellitus (also see, US 6,967,208 and WO 2011/106478).
  • Apixaban has the chemical name (1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]- 4,5,6,7-tetrahydro-1 H-pyrazolo[3,4-c]pyridine-3-carboxamide, and has the following structure:
  • Apixaban can be synthesised according to one or more methods known in the art, see for example WO 2014/072884, US 7,371 ,761 and Y. Ji co et. al., Synthetic Communications 2013, 43, 72-79.
  • the fixed-dose pharmaceutical composition includes apixaban, an antihypertensive selected from amlodipine, torasemide, bisoprolol or metoprolol, and a pharmaceutically acceptable excipient.
  • the composition includes from 1 mg to 15 mg of apixaban, in particular 2.5 mg to 10 mg e.g. 2.5 mg, 5 mg or 10 mg.
  • Amlodipine, torasemide, bisoprolol and metoprolol are antihypertensives that lower blood pressure.
  • the antihypertensive is present at from 0.1 to 5000 mg, or 1 to 1500 mg, 2 to 800 mg, or 5 to 500 mg, e.g. 0.5 to 50 mg or 1 to 100 mg e.g. 2.5 mg, 5 mg, 7.5 mg, 10 mg, 50 mg or 100 mg.
  • Amlodipine is an antihypertensive drug which acts as an angioselective calcium channel blocker. It is marketed globally by numerous pharmaceutical companies, typically in salt form. The most common salts are amlodipine besilate, amlodipine camsylate, amlodipine maleate, amlodipine mesylate and amlodipine besilate monohydrate. Amlodipine is indicated as a monotherapy for the treatment of hypertension, and as a combination therapy with other antihypertensives and antianginal agents for the treatment of coronary artery disease, chronic stable angina and vasospastic angina.
  • Amlodipine has the chemical name 3-O-ethyl 5-O-methyl (4 RS) 2-(2-aminoethoxymethyl)-4-(2- chlorophenyl)-6-methyl-1 ,4-dihydropyridine-3,5-dicarboxylate, and has the following structure:
  • Amlodipine can be synthesised according to one or more methods known in the art, see for example US 4,572,909 and WO 2004/058711 .
  • the fixed-dose pharmaceutical composition includes an anticoagulant selected from rivaroxaban or apixaban, amlodipine and a pharmaceutically acceptable excipient.
  • the composition may include a pharmaceutically acceptable salt of amlodipine, for example, amlodipine besilate, amlodipine camsylate, amlodipine maleate, amlodipine mesylate or amlodipine besilate monohydrate. Most preferably the composition includes amlodipine besilate.
  • the composition includes from 1 mg to 15 mg of amlodipine, in particular 5 mg to 10 mg e.g. 5 mg or 10 mg.
  • Torasemide is a loop diuretic. Loop diuretics act on the Na-K-CI cotransporter to inhibit sodium, potassium and chloride reabsorption in the kidney, they also inhibit magnesium and calcium reabsorption in the kidney. A downstream effect of this inhibitory action is diuresis, which reduces the amount of water that can be reabsorbed into the blood, which in turn causes a decrease in blood volume. Loop diuretics also increase prostaglandin production, which in turn causes vasodilation and increases blood supply to the kidney. As a result of decreased blood volume and vasodilation, loop diuretics are able to reduce blood pressure and manage edema. Torasemide is marketed globally by numerous pharmaceutical companies. It is indicated for the treatment of edema associated with congestive heart failure, renal or hepatic diseases, and for the treatment of hypertension.
  • Torasemide has the chemical name 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea, and has the following structure:
  • Torasemide can be synthesised according to one or more methods known in the art, see for example Delarge et. al offset Ann Pharm Fr 1973, 31 , 467-474, US 2,516,025 and WO 01/70226.
  • the fixed-dose pharmaceutical composition includes an anticoagulant selected from rivaroxaban or apixaban, torasemide and a pharmaceutically acceptable excipient.
  • the composition includes from 1 mg to 25 mg of torasemide, in particular 5 mg to 20 mg e.g. 5 mg, 10 mg or 20 mg.
  • Bisoprolol is a beta blocker. Beta blockers act on the sympathetic nervous system by blocking the receptor sites of epinephrine and norepinephrine on adrenergic beta receptors. Bisoprolol is selective for bi-adrenergic receptors which are abundant in the heart and kidneys. Thus, bisoprolol prevents adrenaline and noradrenaline stimulation of the bi-adrenergic receptor by blocking them. This inhibitory action slows the rate and force at which the heart beats, which reduces blood pressure. Bisoprolol is marketed globally by numerous pharmaceutical companies, typically in salt form. The most common salt is bisoprolol fumarate. Bisoprolol is indicated for the treatment of hypertension, angina and as an adjunct for heart failure.
  • Bisoprolol has the chemical name ( ⁇ )-1-(propan-2-ylamino)-3-[4-(2-propan-2- yloxyethoxymethyl)phenoxy]propan-2-ol, and has the following structure:
  • Bisoprolol can be synthesised according to one or more methods known in the art, see for example US 4,258,062 and WO 2007/069266.
  • the fixed-dose pharmaceutical composition includes an anticoagulant selected from rivaroxaban or apixaban, bisoprolol and a pharmaceutically acceptable excipient.
  • the composition may include a pharmaceutically acceptable salt of bisoprolol, for example bisoprolol fumarate.
  • the composition includes from 1 mg to 25 mg of bisoprolol, in particular 2.5 mg to 10 mg e.g. 2.5 mg, 5 mg or 10 mg.
  • metoprolol is a beta blocker which is selective for bi-adrenergic receptors. Metoprolol therefore has a similar mechanism of action and also provides an antihypertensive effect. Metoprolol is marketed globally by numerous pharmaceutical companies, typically in salt form. The most common salts are metoprolol succinate, metoprolol tartrate and metoprolol fumarate. Metoprolol is indicated for the treatment of hypertension, angina, cardiac arrhythmia, for migraine prophylaxis and as an adjunct for hyperthyroidism. Metoprolol has the chemical name ( ⁇ )-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2- ol, and has the following structure:
  • Metoprolol can be synthesised according to one or more methods known in the art, see for example EP 0 050 885, US 5,082,969 and WO 2007/141593.
  • the fixed-dose pharmaceutical composition includes an anticoagulant selected from rivaroxaban or apixaban, metoprolol and a pharmaceutically acceptable excipient.
  • the composition may include a pharmaceutically acceptable salt of metoprolol, for example metoprolol succinate, metoprolol tartrate or metoprolol fumarate.
  • the composition includes metoprolol succinate.
  • the composition includes from 25 mg to 125 mg of metoprolol, in particular 50 mg to 100 mg e.g. 50 mg or 100 mg.
  • the invention provides a fixed-dose pharmaceutical composition comprising:
  • the composition comprises rivaroxaban or apixaban and amlodipine, and the wt ratio of rivaroxaban or apixaban to amlodipine is selected from:
  • composition comprises rivaroxaban and amlodipine, and the wt ratio of rivaroxaban to amlodipine is selected from:
  • the composition comprises rivaroxaban or apixaban and torasemide, and the wt ratio of rivaroxaban or apixaban to amlodipine is selected from:
  • the composition comprises rivaroxaban or apixaban and torasemide and the wt ratio of rivaroxaban or apixaban to amlodipine is selected from:
  • composition comprises apixaban and torasemide, and the wt ratio of apixaban to torasemide is selected from:
  • the composition comprises rivaroxaban or apixaban and bisoprolol, and the wt ratio of rivaroxaban or apixaban to bisoprolol is selected from:
  • the composition comprises rivaroxaban and bisoprolol, and the wt ratio of rivaroxaban to bisoprolol is selected from:
  • the composition comprises rivaroxaban or apixaban and metoprolol, and the wt ratio of rivaroxaban or apixaban to metoprolol is selected from:
  • composition comprises apixaban and metoprolol, and the wt ratio of apixaban to metoprolol is selected from:
  • the fixed-dose pharmaceutical composition includes from 10 mg to 20 mg rivaroxaban, from 5 mg to 10 mg amlodipine and a pharmaceutically acceptable excipient.
  • the composition includes from 10 mg to 20 mg rivaroxaban, from 5 mg to 10 mg amlodipine and a pharmaceutically acceptable excipient, wherein the composition is an oral dosage form selected from a monolayer or bilayer tablet, or a capsule.
  • the fixed-dose pharmaceutical includes:
  • composition includes:
  • the oral dosage form is a tablet, for example a monolayer or bilayer tablet or a capsule.
  • the composition includes 20 mg rivaroxaban and 10 mg amlodipine wherein the oral dosage form is a monolayer or bilayer tablet, or the composition includes 20 mg rivaroxaban and 5 mg amlodipine wherein the oral dosage form is a monolayer or bilayer tablet.
  • the fixed-dose pharmaceutical composition includes from 10 mg to 20 mg rivaroxaban, from 5 mg to 20 mg torasemide and a pharmaceutically acceptable excipient.
  • the composition includes from 10 mg to 20 mg rivaroxaban, from 5 mg to 20 mg torasemide and a pharmaceutically acceptable excipient, wherein the composition is an oral dosage form selected from a monolayer or bilayer tablet, or a capsule.
  • composition includes:
  • the composition is an oral dosage form.
  • the oral dosage form is a tablet, for example a monolayer or bilayer tablet or a capsule.
  • the fixed-dose pharmaceutical composition includes from 10 mg to 20 mg rivaroxaban, from 2.5 mg to 10 mg bisoprolol and a pharmaceutically acceptable excipient.
  • the composition includes from 10 mg to 20 mg rivaroxaban, from 2.5 mg to 10 mg bisoprolol and a pharmaceutically acceptable excipient, wherein the composition is an oral dosage form selected from a monolayer or bilayer tablet, or a capsule.
  • the fixed-dose pharmaceutical composition includes:
  • composition includes:
  • the composition is an oral dosage form.
  • the oral dosage form is a tablet, for example a monolayer or bilayer tablet or a capsule.
  • the fixed-dose pharmaceutical composition includes from 5 mg to 10 mg apixaban, from 5 mg to 10 mg torasemide and a pharmaceutically acceptable excipient.
  • the composition includes from 5 mg to 10 mg apixaban, from 5 mg to 10 mg torasemide and a pharmaceutically acceptable excipient, wherein the composition is an oral dosage form selected from a monolayer or bilayer tablet, or a capsule.
  • the apixaban is formulated in the aforementioned tablet or capsule oral dosage form to provide controlled release of apixaban from the oral dosage form.
  • composition includes:
  • the composition is an oral dosage form.
  • the oral dosage form is a tablet, for example a monolayer or bilayer tablet or a capsule.
  • the apixaban is formulated in the aforementioned tablet or capsule oral dosage form to provide controlled release of apixaban from the oral dosage form.
  • the fixed-dose pharmaceutical composition includes from 2.5 mg to 5 mg apixaban, from 50 mg to 100 mg metoprolol and a pharmaceutically acceptable excipient.
  • the composition includes from 2.5 mg to 5 mg apixaban, from 50 mg to 100 mg metoprolol and a pharmaceutically acceptable excipient, wherein the composition is an oral dosage form selected from a monolayer or bilayer tablet, or a capsule.
  • metoprolol • 5 mg apixaban and 100 mg metoprolol; and a pharmaceutically acceptable excipient, wherein metoprolol is included in the composition as a free base or as a pharmaceutically acceptable salt of metoprolol, for example metoprolol succinate.
  • composition includes:
  • the oral dosage form is a tablet, for example a monolayer or bilayer tablet or a capsule.
  • the combinations of active ingredients as defined herein by the fixed-dose pharmaceutical compositions produce an increased therapeutic effect relative to the therapeutic effect of the individual components when administered alone or when administered in combination according to independent dosage regimens, i.e. not as a fixed-dose composition.
  • the combination of active ingredients may, relative to the individual components when administered alone, provide additivity and synergism.
  • a “synergistic" effect occurs when the combination of active ingredients provides an effect which is larger than the sum of the therapeutic effects of the agents administered alone.
  • the term "combination” means that the components are administered as part of the same overall treatment regimen, as the fixed-dose pharmaceutical compositions defined herein.
  • the fixed-dose pharmaceutical compositions are generally administered to a subject in need of such administration, for example a human or animal, typically a human.
  • the fixed-dose pharmaceutical compositions will typically be administered in amounts that are therapeutically or prophylactically useful.
  • the compounds may be administered over a prolonged term to maintain beneficial therapeutic effects or may be administered for a short period only.
  • a typical daily dose of the compounds can be in the range from 100 picograms to 100 milligrams per kilogram of body weight, typically 10 nanograms to 10 milligrams per kilogram of bodyweight, more typically 1 microgram to 10 milligrams although higher or lower doses may be administered where required.
  • the quantity of compound administered will be commensurate with the nature of the disease or physiological condition being treated and will be at the discretion of the physician.
  • compositions and dosage regimens include:
  • the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention are suitable for use in the treatment or prevention of stroke and systemic embolism.
  • the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention are also suitable for use in the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention are also suitable for use in the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: congestive heart failure, hypertension, previous stroke ortransient ischaemic attack, age > 75 years or, diabetes mellitus.
  • the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention are also suitable for use in the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: previous stroke or transient ischaemic attack, symptomatic heart failure, diabetes mellitus, hypertension or age > 75 years.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism, or a method for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension comprising administering to a human a fixed-dose pharmaceutical composition comprising any of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age > 75 years or, diabetes mellitus comprising administering to a human a fixed-dose pharmaceutical composition comprising any of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: previous stroke or transient ischaemic attack, symptomatic heart failure, diabetes mellitus, hypertension or age > 75 years comprising administering to a human a fixed-dose pharmaceutical composition comprising any of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention.
  • the invention also provides the use of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism, or for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • the invention also provides the use of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age > 75 years or, diabetes mellitus.
  • the invention also provides the use of the fixed-dose pharmaceutical compositions as defined herein by the first and second aspects of the invention for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at least one risk factor selected from: previous stroke or transient ischaemic attack, symptomatic heart failure, diabetes mellitus, hypertension or age > 75 years.
  • the fixed-dose pharmaceutical composition is administered once-daily, twice-daily or th rice-daily.
  • the fixed-dose pharmaceutical composition is administered once-daily.
  • the fixed-dose pharmaceutical composition is administered twice-daily.
  • compositions include one or more pharmaceutically acceptable excipients.
  • the pharmaceutically acceptable excipient(s) can be selected from, for example, carriers (e.g. a solid, liquid or semi-solid carrier), adjuvants, diluents, fillers or bulking agents, granulating agents, coating agents, release-controlling agents, binding agents, disintegrants, lubricating agents, preservatives, antioxidants, buffering agents, suspending agents, thickening agents, flavouring agents, sweeteners, taste masking agents, stabilisers or any other excipients conventionally used in pharmaceutical compositions.
  • carriers e.g. a solid, liquid or semi-solid carrier
  • adjuvants e.g. a solid, liquid or semi-solid carrier
  • pharmaceutically acceptable refers to compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of a subject (e.g. a human subject) without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
  • a subject e.g. a human subject
  • Each excipient must also be “acceptable” in the sense of being compatible with the other ingredients of the formulation.
  • compositions as defined herein can be can be formulated in accordance with known techniques, see for example, Remington’s Pharmaceutical Sciences, Mack Publishing Company, Easton, PA, USA.
  • the fixed-dose pharmaceutical compositions of the invention are preferably formulated as oral dosage forms.
  • compositions are instant release formulations. In another embodiment, the compositions are extended release compositions.
  • Oral dosage forms include tablets (coated or uncoated), capsules (hard or soft shell), caplets, pills, lozenges, syrups, solutions, powders, granules, elixirs and suspensions, sublingual tablets, wafers or patches such as buccal patches.
  • compositions are provided as tablets, for example a monolayer or bilayer tablet or as capsules.
  • a monolayer tablet has a single layer, where the active ingredients and excipients are present in a single uniform structure.
  • a bilayer tablet has two layers, where the active ingredients and excipients are present as a uniform structure in two separate layers.
  • compositions are provided as monolayer tablets, both active ingredients are contained within said monolayer. That is, the anticoagulant and antihypertensive are contained within the same layer, along with the excipients.
  • compositions are provided as a bilayer tablets, one layer contains the anticoagulant and excipient, and the other layer contains the antihypertensive and excipient.
  • the composition includes 20 mg rivaroxaban and 10 mg amlodipine wherein the composition is an oral dosage form that is a monolayer or bilayer tablet, or the composition includes 20 mg rivaroxaban and 5 mg amlodipine wherein the oral dosage form is a monolayer or bilayer tablet.
  • the rivaroxaban part of the tablet is preferably prepared according to a wet granulation/dispersion process
  • the amlodipine part is preferably prepared according to a direct compression blending process.
  • the rivaroxaban and amlodipine parts are then preferably compressed together to form a bilayer tablet.
  • amlodipine-containing part of the bilayer tablet preferably the amlodipine, diluent, disintegrant, glidant and optionally any colourants are mixed in a blender. During the mixing process, a lubricant may be added thereto, and the resulting mixture is thoroughly mixed.
  • the rivaroxaban part and the amlodipine part are compressed together.
  • the fixed-dose pharmaceutical composition is a bilayer tablet comprising a rivaroxaban part and an amlodipine part, wherein the rivaroxaban part is obtained by o dissolving at least a binding agent and a wetting agent in water to provide a dispersion solution; o suspending rivaroxaban in the dispersion solution to provide a dispersion suspension; o mixing at least a diluent, a disintegrant and optionally rivaroxaban together to form a pre-mixture; and o spraying the dispersion suspension onto the pre-mixture to form rivaroxaban granules in a wet granulation step wherein the amlodipine part is obtained by o mixing amlodipine, and at least a diluent, disintegrant and glidant; and wherein the bilayer tablet is obtained by bringing together the rivaroxaban part and the amlodipine part.
  • the bilayer tablet is obtained by bringing together the rivaroxaban part and the amlodipine part in a direct compression step.
  • the binding agent includes hydroxypropylmethylcellulose, and the wetting agent includes sodium lauryl sulfate.
  • 100% of the rivaroxaban that is required to be contained in the final dosage form is suspended in dispersion solution.
  • 10 to 30% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 70-90% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture; or 15 to 25% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 75-85% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture; or 20% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 80% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture.
  • the pre-mixture includes a diluent, e.g. microcrystalline cellulose or lactose monohydrate or mannitol, and disintegrant e.g. croscarmellose, and optionally rivaroxaban.
  • a diluent e.g. microcrystalline cellulose or lactose monohydrate or mannitol
  • disintegrant e.g. croscarmellose, and optionally rivaroxaban.
  • the pre-mixture does not include sodium starch glycolate as a diluent.
  • the wet granulation step used to prepare the rivaroxaban granules is performed in a high- shear mechanical grinder (HSMG), and then the granules are dried in a fluid bed drier.
  • HSMG high- shear mechanical grinder
  • the wet granulation step used to prepare the rivaroxaban granules is a wet fluidized-bed granulation.
  • the granules may be dried, sieved and milled, and a lubricant e.g. magnesium stearate may be added thereto.
  • a lubricant e.g. magnesium stearate
  • amlodipine part preferably at least croscarmellose sodium or sodium starch glycolate is used as a disintegrant.
  • lactose is not used as a diluent.
  • the rivaroxaban and amlodipine parts of the tablet are preferably preferred according to the process described for the bilayer tablet.
  • the rivaroxaban and amlodipine parts are brought together and compressed as a monolayer tablet.
  • a process for preparing a fixed-dose composition wherein the composition is an oral dosage form bilayer tablet, comprising a rivaroxaban part and an amlodipine part, comprising the steps of: o dissolving at least a binding agent and a wetting agent in water to provide a dispersion solution; o suspending rivaroxaban in the dispersion solution to provide a dispersion suspension; o mixing at least a diluent, a disintegrant and optionally rivaroxaban together to form a pre- mixture; o spraying the dispersion suspension onto the pre-mixture to form rivaroxaban granules in a wet granulation step, to provide the rivaroxaban part, and o mixing amlodipine, and at least a diluent, disintegrant and glidant, to provide the amlodipine part; and o bringing together the rivaroxaban part and the aml
  • the bilayer tablet is obtained by bringing together the rivaroxaban part and the amlodipine part in a direct compression step.
  • the binding agent includes hydroxypropylmethylcellulose
  • the wetting agent includes sodium lauryl sulfate.
  • 100% of the rivaroxaban that is required to be contained in the final dosage form is suspended in dispersion solution.
  • 10 to 30% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 70-90% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture; or 15 to 25% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 75-85% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture; or 20% of the rivaroxaban that is required to be contained in the final dosage form is suspended in the dispersion solution, and 80% of the rivaroxaban that is required to be contained in the final dosage form is included in the pre-mixture.
  • the pre-mixture includes a diluent, e.g. microcrystalline cellulose or lactose monohydrate or mannitol, and disintegrant e.g. croscarmellose, and optionally rivaroxaban.
  • a diluent e.g. microcrystalline cellulose or lactose monohydrate or mannitol
  • disintegrant e.g. croscarmellose, and optionally rivaroxaban.
  • the pre-mixture does not include sodium starch glycolate as a diluent.
  • the wet granulation step used to prepare the rivaroxaban granules is performed in a high- shear mechanical grinder, and then the granules are dried in a fluid bed drier.
  • the wet granulation step used to prepare the rivaroxaban granules is a wet fluidized-bed granulation.
  • the granules may be dried, sieved and milled, and a lubricant e.g. magnesium stearate may be added thereto.
  • amlodipine part preferably at least croscarmellose sodium or sodium starch glycolate is used as a disintegrant.
  • lactose is not used as a diluent.
  • compositions are provided in capsules
  • the active ingredients the anticoagulant and antihypertensive are contained within a single capsule.
  • the anticoagulant and antihypertensive may be contained as separate powders or granulates in the capsule, or the anticoagulant and antihypertensive may be formulated together as a single granulate with excipient.
  • the fixed-dose pharmaceutical compositions defined herein may be formulated as tablet compositions, that may contain the active ingredients as defined herein together with an inert diluent, filler or carrier such as a sugar or sugar alcohol, eg; lactose, sucrose, sorbitol or mannitol; and/or a non-sugar derived diluent such as sodium carbonate, calcium phosphate, calcium carbonate, or a cellulose or derivative thereof such as microcrystalline cellulose (MCC), methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, and starches such as corn starch.
  • an inert diluent filler or carrier
  • a sugar or sugar alcohol eg; lactose, sucrose, sorbitol or mannitol
  • a non-sugar derived diluent such as sodium carbonate, calcium phosphate, calcium carbonate, or a cellulose or derivative thereof such as microcrystalline cellulose (MC
  • Tablets may also contain such standard ingredients as binding and granulating agents such as polyvinylpyrrolidone, disintegrants (e.g. swellable crosslinked polymers such as crosslinked carboxymethylcellulose), lubricating agents (e.g. stearates), preservatives (e.g. parabens), antioxidants (e.g. BHT), buffering agents (for example phosphate or citrate buffers), and effervescent agents such as citrate/bicarbonate mixtures.
  • binding and granulating agents such as polyvinylpyrrolidone, disintegrants (e.g. swellable crosslinked polymers such as crosslinked carboxymethylcellulose), lubricating agents (e.g. stearates), preservatives (e.g. parabens), antioxidants (e.g. BHT), buffering agents (for example phosphate or citrate buffers), and effervescent agents such as citrate/bicarbonate mixtures.
  • disintegrants e
  • compositions of the invention are formulated with a pharmaceutically acceptable filler or bulking agent.
  • excipients include dibasic calcium phosphate anhydrous, magnesium stearate, silicon dioxide, carboxymethylcellulose, crospovidone, and hydroxypropyl cellulose dosage forms capsule or tablet.
  • Tablets may be designed to release the active ingredient either upon contact with stomach fluids (immediate release tablets) or to release in a controlled manner (controlled release tablets) over a prolonged period of time or with a specific region of the Gl tract.
  • the apixaban may be formulated to provide immediate release or controlled release of apixaban from the dosage form.
  • the composition is a monolayer tablet.
  • the monolayer tablet comprises:
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • the monolayer tablet comprises: • rivaroxaban
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • the monolayer tablet comprises:
  • amlodipine e.g. amlodipine besilate
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • the monolayer tablet comprises:
  • amlodipine e.g. amlodipine besilate
  • a filler such as microcrystalline cellulose, calcium phosphate or starch, but not lactose
  • the composition is a bilayer tablet.
  • the bilayer tablet comprises:
  • a first layer comprising o the anticoagulant; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein; and
  • a second layer comprising o the antihypertensive; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises:
  • a first layer comprising o rivaroxaban; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein; and ⁇ a second layer comprising o torasemide; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises: • a first layer comprising o rivaroxaban; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o a disintegrant, such as croscarmellose sodium, wherein the disintegrant is not sodium starch glycolate; and o one or more additional pharmaceutically acceptable excipients as defined herein; and
  • a second layer comprising o amlodipine (e.g. amlodipine besilate); o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • amlodipine e.g. amlodipine besilate
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises:
  • a first layer comprising o rivaroxaban; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; and o one or more additional pharmaceutically acceptable excipients as defined herein; and
  • a second layer comprising o amlodipine (e.g. amlodipine besilate); o a filler, such as microcrystalline cellulose, calcium phosphate or starch, but not lactose; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • amlodipine e.g. amlodipine besilate
  • a filler such as microcrystalline cellulose, calcium phosphate or starch, but not lactose
  • additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises:
  • a first layer comprising o rivaroxaban; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; o a disintegrant, such as croscarmellose sodium, wherein the disintegrant is not sodium starch glycolate; and o one or more additional pharmaceutically acceptable excipients as defined herein; and
  • a second layer comprising o amlodipine (e.g. amlodipine besilate); o a filler, such as microcrystalline cellulose, calcium phosphate or starch, but not lactose; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • amlodipine e.g. amlodipine besilate
  • a filler such as microcrystalline cellulose, calcium phosphate or starch, but not lactose
  • additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises:
  • a first layer comprising o rivaroxaban; o a filler, such as lactose, microcrystalline cellulose, calcium phosphate or starch; o a disintegrant, such as croscarmellose sodium, wherein the disintegrant is not sodium starch glycolate; and o one or more additional pharmaceutically acceptable excipients as defined herein; and
  • a second layer comprising o amlodipine (e.g. amlodipine besilate); o a filler, such as microcrystalline cellulose, calcium phosphate or starch, but not lactose; o a disintegrant, such as croscarmellose sodium or sodium starch glycolate; and o one or more additional pharmaceutically acceptable excipients as defined herein.
  • amlodipine e.g. amlodipine besilate
  • a filler such as microcrystalline cellulose, calcium phosphate or starch, but not lactose
  • o a disintegrant such as croscarmellose sodium or sodium starch glycolate
  • additional pharmaceutically acceptable excipients as defined herein.
  • the filler in the first layer may also be mannitol.
  • the bilayer tablet comprises:
  • a first layer comprising o rivaroxaban, and one or more additional pharmaceutically acceptable excipients as defined herein, wherein the total weight of the first layer does not exceed 165 mg;
  • a second layer comprising o amlodipine (e.g. amlodipine besilate) and one or more additional pharmaceutically acceptable excipients as defined herein.
  • o amlodipine e.g. amlodipine besilate
  • additional pharmaceutically acceptable excipients as defined herein.
  • the bilayer tablet comprises: ⁇ a first layer comprising o rivaroxaban, and one or more additional pharmaceutically acceptable excipients as defined herein, wherein the total weight of the first layer does not exceed 165 mg; and
  • a second layer comprising o amlodipine (e.g. amlodipine besilate) and one or more additional pharmaceutically acceptable excipients as defined herein, wherein the total weight of the second layer does not exceed 205 mg.
  • o amlodipine e.g. amlodipine besilate
  • additional pharmaceutically acceptable excipients as defined herein, wherein the total weight of the second layer does not exceed 205 mg.
  • Capsule formulations may be of the hard gelatin or soft gelatin variety and can contain the active component in solid, semi-solid, or liquid form.
  • Gelatin capsules can be formed from animal gelatin or synthetic or plant derived equivalents thereof. Hydroxypropyl methyl cellulose (HPMC) capsules are also suitable.
  • HPMC Hydroxypropyl methyl cellulose
  • the composition is a capsule formulation.
  • the capsule formulation comprises:
  • the capsule formulation comprises:
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • the capsule formulation comprises:
  • amlodipine e.g. amlodipine besilate
  • a filler such as lactose, microcrystalline cellulose, calcium phosphate or starch
  • the solid dosage forms can be coated or un-coated. Coatings may act either as a protective film (e.g. a polymer, wax or varnish) or as a mechanism for controlling active ingredient release or for aesthetic or identification purposes.
  • the coating e.g. a Eudragit TM type polymer
  • the coating can be designed to release the active component at a desired location within the gastrointestinal tract.
  • the coating can be selected so as to degrade under certain pH conditions within the gastrointestinal tract, thereby selectively release the compound in the stomach or in the ileum, duodenum, jejenum or colon.
  • the active ingredient can be presented in a solid matrix comprising a release controlling agent, for example a release delaying agent which may be adapted to release the compound in a controlled manner in the gastrointestinal tract.
  • a release controlling agent for example a release delaying agent which may be adapted to release the compound in a controlled manner in the gastrointestinal tract.
  • the active ingredient can be presented in a polymer coating e.g. a polymethacrylate polymer coating, which may be adapted to selectively release the compound under conditions of varying acidity or alkalinity in the gastrointestinal tract.
  • the matrix material or release retarding coating can take the form of an erodible polymer (e.g. a maleic anhydride polymer) which is substantially continuously eroded as the dosage form passes through the gastrointestinal tract.
  • the coating can be designed to disintegrate under microbial action in the gut.
  • the active compound can be formulated in a delivery system that provides osmotic control of the release of the compound. Osmotic release and other delayed release or sustained release formulations (for example formulations based on ion exchange resins) may be prepared in accordance with methods well known to those skilled in the art.
  • tablets and capsules typically contain 0-20% disintegrants, 0-5% lubricants, 0-5% flow aids and/or 0-99% (w/w) fillers/ or bulking agents (depending on active ingredient dose). They may also contain 0-10% (w/w) polymer binders, 0-5% (w/w) antioxidants, 0-5% (w/w) pigments. Slow release tablets would in addition contain 0-99% (w/w) polymers (depending on dose).
  • the film coats of the tablet or capsule typically contain 0-10% (w/w) release-controlling (e.g. delaying) polymers, 0-3% (w/w) pigments, and/or 0-2% (w/w) plasticizers.
  • the invention provides a fixed-dose pharmaceutical composition comprising:
  • the invention also provides a fixed-dose pharmaceutical composition comprising: ⁇ an anticoagulant;
  • an antihypertensive • an antihypertensive; and a pharmaceutically acceptable excipient, for use in the treatment or prevention of stroke and systemic embolism, or for use in the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism, or a method for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension comprising administering to a human a fixed-dose pharmaceutical composition comprising:
  • the invention also provides the use of a fixed-dose pharmaceutical composition
  • a fixed-dose pharmaceutical composition comprising:
  • the invention provides a fixed-dose pharmaceutical composition comprising an anticoagulant which is a factor Xa inhibitor, an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker, and a pharmaceutically acceptable excipient.
  • the invention also provides a fixed-dose pharmaceutical composition comprising an anticoagulant which is a factor Xa inhibitor, an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker, and a pharmaceutically acceptable excipient, for use in the treatment or prevention of stroke and systemic embolism, or for use in the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • the invention also provides a method for the treatment or prevention of stroke and systemic embolism, or a method for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension comprising administering to a human a fixed-dose pharmaceutical composition comprising an anticoagulant which is a factor Xa inhibitor, an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker, and a pharmaceutically acceptable excipient.
  • an anticoagulant which is a factor Xa inhibitor
  • an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker
  • a pharmaceutically acceptable excipient comprising administering to a human a fixed-dose pharmaceutical composition comprising an anticoagulant which is a factor Xa inhibitor, an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker, and a pharmaceutically acceptable excipient.
  • the invention also provides the use of a fixed-dose pharmaceutical composition
  • a fixed-dose pharmaceutical composition comprising an anticoagulant which is a factor Xa inhibitor, an antihypertensive which is selected from a calcium channel blocker, a diuretic or a beta blocker, and a pharmaceutically acceptable excipient for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism, or for the manufacture of a medicament for the treatment or prevention of stroke and systemic embolism in patients with essential hypertension.
  • a monolayer tablet composition containing rivaroxaban and amlodipine was prepared by wet granulating rivaroxaban and excipients to form a granulated mixture. Amlodipine was incorporated into the mixture by extragranular addition, and the mixture was compressed into a tablet.
  • a bilayer tablet composition containing rivaroxaban and amlodipine was prepared by wet granulating rivaroxaban and excipients to form a granulated mixture, and by wet granulating amlodipine and excipients to form a granulated mixture.
  • the respective mixtures were provided as layers and compressed into a tablet. Rivaroxaban/amlodipine capsules
  • a capsule formulation was prepared by combining rivaroxaban and amlodipine with filler and appropriate excipients (e.g. disintegrant and/or glidant) and then filling the resulting mixture into HPMC/gelatin capsules.
  • excipients e.g. disintegrant and/or glidant
  • a monolayer tablet composition containing rivaroxaban and torasemide was prepared by wet granulating rivaroxaban and excipients to form a granulated mixture. Torasemide was incorporated into the mixture by extragranular addition, and the mixture was compressed into a tablet. Rivaroxaban/torasemide bilaver tablet
  • a bilayer tablet composition containing rivaroxaban and torasemide was prepared by wet granulating rivaroxaban and excipients to form a granulated mixture, and by wet granulating torasemide and excipients to form a granulated mixture.
  • the respective mixtures were provided as layers and compressed into a tablet.
  • a capsule formulation was prepared by combining rivaroxaban and torasemide with filler and appropriate excipients (e.g. disintegrant and/or glidant) and then filling the resulting mixture into HPMC/gelatin capsules.
  • excipients e.g. disintegrant and/or glidant
  • a two-arm clinical assessment may be performed as follows:
  • Patients in the test arm may be administered a fixed-dose composition including an anticoagulant and an antihypertensive, whereas patients in the comparator arm may be administered a non-fixed combination of an anticoagulant and an antihypertensive, or patients may be administered an. anticoagulant or an antihypertensive monotherapy.
  • the patients in the comparator arm may receive the anticoagulant and antihypertensive according to their approved dosage regimen, whereas patients in the test arm may receive a single fixed-dose composition included the same dosage.
  • the patients in the test arm may be administered a fixed-dose composition including an anticoagulant and an antihypertensive
  • patients in the comparator arm may be administered a different fixed-dose composition including an anticoagulant and an antihypertensive.
  • the fixed-dose composition may provide unexpected advantageous effects according to the following rationale.
  • Patients at highest risk of stroke and systemic embolism typically receive greater than five separate medications to manage their condition.
  • AF atrial fibrillation
  • the use of five or more separate medications not only requires a great deal of patient compliance, it also raises long term concerns with respect to patient safety.
  • a fixed-dose composition including an anticoagulant and antihypertensive as described herein, for example rivaroxaban orapixaban, with amlodipine, torasemide, bisoprolol ormetoprolol may provide unexpected benefits in the treatment and prevention of stroke and systemic embolism in patients with and without essential hypertension.
  • the efficacy of rivaroxaban or apixaban to prevent coagulation may unexpectedly boost the efficacy of the antihypertensives.
  • patients who previously required five or more separate medications to treat, prevent and/or manage their risk of stroke and systemic embolism can now do so by taking only two medicaments in a fixed-dose composition.
  • Trials 1 and 2 Examples of potential trials include the following: Trials 1 and 2:
  • a clinical trial may be performed to assess the comparative efficacy of a fixed-dose combination including 10 mg rivaroxaban and 10 mg amlodipine, and a non fixed-dose combination including 10 mg rivaroxaban and 10 mg amlodipine, for the treatment and prevention of stroke and systemic embolism in patients with essential hypertension.
  • a patient in the test arm may be administered a fixed-dose combination including 10 mg rivaroxaban and 10 mg amlodipine, whereas a patient in the comparator arm may be individually administered a 10 mg dose of rivaroxaban and a 10 mg dose of amlodipine.
  • the patients in the comparator arm may receive their dose of rivaroxaban and amlodipine according to the approved dosing guidelines.
  • a clinical trial may be performed to assess the comparative efficacy of a fixed-dose combination including 20 mg rivaroxaban and 10 mg amlodipine, and a non fixed-dose combination including 20 mg rivaroxaban and 10 mg amlodipine, for the treatment and prevention of stroke and systemic embolism in patients with essential hypertension.
  • a patient in the test arm may be administered a fixed-dose combination including 20 mg rivaroxaban and 10 mg amlodipine, whereas a patient in the comparator arm may be individually administered a 20 mg dose of rivaroxaban and a 10 mg dose of amlodipine.
  • a clinical trial may be performed to assess the comparative efficacy of a fixed-dose combination including 20 mg rivaroxaban and 10 mg amlodipine, 20 mg rivaroxaban monotherapy and 10 mg amlodipine monotherapy, for the treatment and prevention of stroke and systemic embolism in patients with essential hypertension.
  • a patient in the test arm may be administered a fixed-dose combination including 20 mg rivaroxaban and 10 mg amlodipine, whereas a patient in the comparator arm may be individually administered a 20 mg dose of rivaroxaban or a 10 mg dose of amlodipine.
  • the relative efficacy of the combinations in the test and comparator arms may be measured, and in particular the synergy of the combinations can be determined.
  • the drug:drug interactions can be determined.
  • a clinical trial may be performed to assess the comparative efficacy of a fixed-dose combination including 20 mg or 10 mg rivaroxaban and 10 mg amlodipine, and a non fixed-dose combination including a different fixed-dose combination, for the treatment and prevention of stroke and systemic embolism in patients with essential hypertension.
  • a patient in the test arm may be administered a fixed-dose combination including 20 mg or 10 mg rivaroxaban and 10 mg amlodipine, whereas a patient in the comparator arm may be individually administered a comparative fixed-dose composition including a different drug combination.
  • the fixed-dose composition of rivaroxaban and amlodipine may unexpectedly provide improved effects with respect to the comparative fixed-dose combination.
  • Rivaroxaban/Amlodipine bilaver tablets 20mq/10mq A bilayer tablet (047D) was prepared according to the following process.
  • the rivaroxaban part was prepared by wet granulation and the amlodipine part by direct compression.
  • Part I Granulation in high shear mechanical granulator (HSMG) - rivaroxaban part
  • composition of the tablet is shown in Table 3.1.1
  • associated dissolution and stability data are shown in Table 3.1 .2 and Table 3.1 .3 respectively.
  • T047D Dissolution of T047D is satisfactory for rivaroxaban as well as for amlodipine.
  • a first monolayer tablet (061 D) was prepared according to the following process.
  • the rivaroxaban part was prepared by wet granulation and amlodipine was added during a blending stage.
  • composition of the tablet is shown in Table 3.2.1.
  • a second monolayer tablet (097D) was prepared according to the following process.
  • the rivaroxaban part was prepared by wet granulation and amlodipine was added during a blending stage.
  • composition of the tablet is shown in Table 3.2.2.
  • a bilayer tablet (067D) was prepared according to the following process.
  • the rivaroxaban part was prepared by wet granulation 80% drug in dry mix and 20% drug dispersion spraying in fluidised bed processor (FBP) and the amlodipine part by direct compression.
  • FBP fluidised bed processor
  • composition of the tablet is shown in Table 3.3.1 , and the associated dissolution data is shown in Table 3.3.2.
  • Three bilayer tablets (066D, 073D and 099D) were prepared according to the following process.
  • the rivaroxaban part was prepared by wet granulation 100% drug in dispersion spraying in FBP and the amlodipine part by direct compression.
  • compositions of the tablets are shown in Table 3.4.1 , and the associated dissolution data is shown in Table 3.4.2.
  • a bilayer tablet (071 D) was prepared according to the following process.
  • the rivaroxaban part and the amlodipine part were prepared by direct compression.
  • composition of the tablet is shown in Table 3.5.1
  • associated dissolution data is shown in Table 3.5.2.
  • the rivaroxaban part was prepared by wet granulation 80% drug in dry mix and 20% drug dispersion in HSMG and the amlodipine part by direct compression.
  • composition of the tablet is shown in Table 3.5.1
  • associated dissolution data is shown in Table 3.5.2.
  • composition of the tablet is shown in Table 3.6.1
  • dissolution data is shown in Table 3.6.2 (rivaroxaban) and Table 3.6.3 (amlodipine).
  • 095D and 096D display dissolution profiles for both rivaroxaban and amlodipine which are equivalent to the dissolution profiles of each of the mono-products Xarelto and Istin.

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Abstract

L'invention concerne des compositions pharmaceutiques à dose fixe comprenant : • de 1 à 25 mg de rivaroxaban ou d'apixaban ; • de l'amlodipine, de la torasémide, du bisoprolol ou du métoprolol ; et • un excipient pharmaceutiquement acceptable. L'invention concerne également leur utilisation dans le traitement ou la prévention d'un accident vasculaire cérébral et d'une embolie systémique, et le traitement et la prévention d'un accident vasculaire cérébral et d'une embolie systémique chez des patients atteints d'hypertension essentielle.
EP22707862.3A 2021-02-23 2022-02-23 Compositions pharmaceutiques à dose fixe Pending EP4297733A1 (fr)

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GBGB2102575.4A GB202102575D0 (en) 2021-02-23 2021-02-23 Fixed-dose pharmaceutical compositions
PCT/IB2022/051582 WO2022180531A1 (fr) 2021-02-23 2022-02-23 Compositions pharmaceutiques à dose fixe

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Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516025A (en) 1947-03-27 1950-07-18 Westinghouse Electric Corp Ground-relay transmission-line protection
DE2645710C2 (de) 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
IT1149846B (it) 1980-10-16 1986-12-10 Blasinachim Spa Processo per la sintesi di 1-ammino-3-p(b-metossi-etil)-fenosi-2-propanolo
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
ES2011584A6 (es) 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
CN1203059C (zh) 2000-03-20 2005-05-25 特瓦制药工业有限公司 新的制备托拉塞米中间体的方法
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
AU2002368531A1 (en) 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
RU2429236C2 (ru) 2005-10-04 2011-09-20 Байер Шеринг Фарма Акциенгезельшафт Новая полиморфная форма и аморфная форма 5-хлор-n-({(5s)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1, 3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида
WO2007069266A2 (fr) 2005-12-12 2007-06-21 Unichem Laboratories Limited Nouveau procede de synthese du bisoprolol et de son intermediaire
CA2640876A1 (fr) 2005-12-23 2007-12-13 Medichem, S.A. Synthese et preparations ameliorees du metoprolol et de ses sels
LT3251660T (lt) 2010-02-25 2019-12-10 Bristol Myers Squibb Holdings Ireland Apiksabano vaistinės formos
WO2014072884A1 (fr) 2012-11-12 2014-05-15 Alembic Pharmaceuticals Limited Procédé de synthèse d'apixaban
WO2015198259A1 (fr) 2014-06-26 2015-12-30 Erregierre S.P.A. Procédé de synthèse de rivaroxaban et intermédiaire pour la production de celui-ci

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