EP1296980A1 - Thiazolidinedione salt for treatment of diabetes mellitus - Google Patents

Thiazolidinedione salt for treatment of diabetes mellitus

Info

Publication number
EP1296980A1
EP1296980A1 EP01938400A EP01938400A EP1296980A1 EP 1296980 A1 EP1296980 A1 EP 1296980A1 EP 01938400 A EP01938400 A EP 01938400A EP 01938400 A EP01938400 A EP 01938400A EP 1296980 A1 EP1296980 A1 EP 1296980A1
Authority
EP
European Patent Office
Prior art keywords
hydrobromide
solvate
ethoxy
amino
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01938400A
Other languages
German (de)
French (fr)
Inventor
Andrew Simon SaxoSmithKline CRAIG
Tim Chien Ting GlaxoSmithKline HO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of EP1296980A1 publication Critical patent/EP1296980A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • EP Patent Application, Publication Number 0,306,228 relates to certain thiazolidinedione derivatives disclosed as having hypoglycaemic and hypolipidaemic activity.
  • the compound of example 30 of EP 0,306,228 is 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (hereinafter also referred to as "Compound (I)").
  • Compound (I) forms a novel hydrobromide salt (hereinafter also referred to as the "Hydrobromide”) that is particularly stable and hence is suitable for bulk preparation and handling.
  • the Hydrobromide also has a high melting point, shows particularly good aqueous solubility and possesses good bulk flow properties.
  • the hydrobromide is therefore surprisingly amenable to large scale pharmaceutical processing and especially to large scale miling.
  • the novel form can be prepared by an efficient, economic and reproducible process particularly suited to large-scale preparation.
  • the novel Hydrobromide also has useful pharmaceutical properties and in particular it is indicated to be useful for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof. Accordingly, the present invention provides 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide or a solvate thereof.
  • the hydrobromide is a monohydrobromide.
  • the Hydrobromide provides an infrared spectrum substantially in accordance with Figure I. In one favoured aspect, the Hydrobromide provides a Raman spectrum substantially in accordance with Figure II.
  • the Hydrobromide provides an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table I or Figure III.
  • the Hydrobromide provides a solid-state 13 C NMR spectrum substantially in accordance with Figure IV.
  • the Hydrobromide has a melting point within the range of from 175 to 185°C, especially 180 to 185°C, for example 181°C. Also the Hydrobromide has a T onse t within the range of from 180 to 186°C, for example 182.5°C.
  • the Hydrobromide is characterised in that it provides two or more of: (i) an infrared spectrum substantially in accordance with Figure I; (ii) a Raman spectrum substantially in accordance with Figure II; (iii) an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table I or Figure III;
  • the present invention encompasses the Hydrobromide or solvate thereof isolated in pure form or when admixed with other materials.
  • the Hydrobromide or solvate thereof in isolated form.
  • the Hydrobromide or solvate thereof in a purified form.
  • the invention provides the Hydrobromide or solvate thereof in a solid pharmaceutically acceptable form, such as a solid dosage form, especially when adapted for oral administration.
  • the invention also provides the Hydrobromide or solvate thereof in a pharmaceutically acceptable form, especially in bulk form, such form being particularly capable of being milled. Furthermore, the invention provides the Hydrobromide or solvate thereof in a pharmaceutically acceptable form, especially in bulk form, such form having good flow properties, especially good bulk flow properties.
  • a suitable solvate is a hydrate.
  • the invention also provides a process for preparing the Hydrobromide or solvate thereof, characterised in that 5-[4-[2-( ⁇ -methyl- ⁇ -(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (Compound(I)), or a salt thereof, preferably dispersed or dissolved in a suitable solvent, is reacted with a source of hydrogen bromide and thereafter, if required, a solvate of the Hydrobromide is prepared; and the Hydrobromide or solvate thereof is recovered.
  • Compound(I) 5-[4-[2-( ⁇ -methyl- ⁇ -(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
  • a salt thereof preferably dispersed or dissolved in a suitable solvent
  • a suitable reaction solvent is an alkanol, for example propan-2-ol, or a hydrocarbon, such as toluene, a ketone, such as acetone, an ester, such as ethyl acetate, an ether such as tetrahydrofuran, a nitrile such as acetonitrile, or a halogenated hydrocarbon such as dichlor ⁇ methane, water, or an organic acid such as acetic acid; or a mixture thereof.
  • a hydrocarbon such as toluene, a ketone, such as acetone, an ester, such as ethyl acetate, an ether such as tetrahydrofuran, a nitrile such as acetonitrile, or a halogenated hydrocarbon such as dichlor ⁇ methane, water, or an organic acid such as acetic acid; or a mixture thereof.
  • the source of hydrogen bromide is provided by an aqueous solution of hydrogen bromide, for example a 48% w/w solution in water.
  • the source of hydrogen bromide is a solution of hydrogen bromide in an appropriate solvent, optionally the reaction solvent, for example propan-2-ol.
  • the hydrogen bromide may be added directly to a solution or suspension of Compound(I) in the chosen reaction solvent.
  • An alternative source of hydrogen bromide is provided by a base salt of hydrobromic acid for example ammonium bromide, or the hydrobromic acid salt of an amine, for example ethylamine or diethylamine.
  • the reaction is usually carried out at ambient temperature or at an elevated temperature, for example at the reflux temperature of the solvent, although any convenient temperature that provides the required product may be employed.
  • Solvates, such as hydrates, of the Hydrobromide are prepared according to conventional procedures.
  • Recovery of the required compound generally comprises crystallisation from an appropriate solvent, conveniently the reaction solvent, usually by cooling to a temperature in the range of from 0°C to 60°C, for example 20 to 25°C or from 40 to 50°C.
  • the Hydrobromide may be crystallised from an alcohol such as propan-2-ol or a ketone such as acetone.
  • the recovery comprises initial cooling to a first temperature, such as in the range of from 40 to 50°C, thereby allowing initiating crystallisation and thereafter cooling to a second temperature, suitably in the range of from 0 to 25°C.
  • Crystallisation can also be initiated by seeding with crystals of the Hydrobromide or solvate thereof but this is not essential.
  • Solvates are prepared by use of appropriate conventional methods.
  • Compound (I) is prepared according to known procedures, such as those disclosed in EP 0,306,228 and WO94/05659. The disclosures of EP 0,306,228 and WO94/05659 are incorporated herein by reference.
  • T onset is generally determined by Differential Scanning Calorimetry and has a meaning generally understood in the art, as for example expressed in Pharmaceutical Thermal Analysis, Techniques and Applications", Ford and Timmins, 1989 as "The temperature corresponding to the intersection of the pre-transition baseline with the extrapolated leading edge of the transition” .
  • good flow properties is suitably characterised by the said compound having a Hausner ratio of less than or equal to 1.5, especially of less than or equal to 1.25.
  • Diabetes ratio is an art accepted term. When used herein the term 'prophylaxis of conditions associated with diabetes mellitus' includes the treatment of conditions such as insulin resistance, impaired glucose tolerance, hyperinsulinaemia and gestational diabetes.
  • Diabetes mellitus preferably means Type II diabetes mellitus.
  • Conditions associated with diabetes include hyperglycaemia and insulin resistance and obesity. Further conditions associated with diabetes include hypertension, cardiovascular disease, especially atherosclerosis, certain eating disorders, in particular the regulation of appetite and food intake in subjects suffering from disorders associated with under-eating, such as anorexia nervosa, and disorders associated with over-eating, such as obesity and anorexia bulimia. Additional conditions associated with diabetes include polycystic ovarian syndrome and steroid induced insulin resistance.
  • the complications of conditions associated with diabetes mellitus encompassed herein includes renal disease, especially renal disease associated with the development of Type II diabetes including diabetic nephropathy, glomerulonephritis, glomerular sclerosis, nephrotic syndrome, hypertensive nephrosclerosis and end stage renal disease.
  • the compound of the invention has useful therapeutic properties: The present invention accordingly provides the Hydrobromide or solvate thereof for use as an active therapeutic substance.
  • the present invention provides the Hydrobromide or solvate thereof for use in the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
  • the Hydrobromide or solvate thereof may be administered per se or, preferably, as a pharmaceutical composition also comprising a pharmaceutically acceptable carrier. Suitable methods for formulating the Hydrobromide or solvate thereof are generally those disclosed for Compound (I) in the above mentioned publications. Accordingly, the present invention also provides a pharmaceutical composition comprising the Hydrobromide or solvate thereof and a pharmaceutically acceptable carrier therefor.
  • the Hydrobromide or solvate thereof is normally administered in unit dosage form.
  • the active compound may be administered by any suitable route but usually by the oral or parenteral routes.
  • the compound will normally be employed in the form of a pharmaceutical composition in association with a pharmaceutical carrier, diluent and/or excipient, although the exact form of the composition will naturally depend on the mode of administration.
  • compositions are prepared by admixture and are suitably adapted for oral, parenteral or topical administration, and as such may be in the form of tablets, capsules, oral liquid preparations, powders, granules, lozenges, pastilles, reconstitutable powders, injectable and infusable solutions or suspensions, suppositories and transdermal devices.
  • Orally administrable compositions are preferred, in particular shaped oral compositions, since they are more convenient for general use.
  • Tablets and capsules for oral administration are usually presented in a unit dose, and contain conventional excipients such as binding agents, fillers, diluents, tabletting agents, lubricants, disintegrants, colourants, flavourings, and wetting agents.
  • the tablets may be coated according to well known methods in the art.
  • Suitable fillers for use include cellulose, mannitol, lactose and other similar agents.
  • Suitable disintegrants include starch, polyvinylpyrrolidone and starch derivatives such as sodium starch glycollate.
  • Suitable lubricants include, for example, magnesium stearate.
  • Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate.
  • Solid oral compositions may be prepared by conventional methods of blending, filling, tabletting or the like. Repeated blending operations may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are, of course, conventional in the art.
  • Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups, or elixirs, or may be presented as a dry product for reconstitution with water or other suitable vehicle before use.
  • Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; non-aqueous vehicles (which may include edible oils), for example, almond oil, fractionated coconut oil, oily esters such as esters of glycerine, propylene glycol, or ethyl alcohol; preservatives, for example methyl or propyl
  • suspending agents for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate, or acacia
  • non-aqueous vehicles which may include edible oils
  • almond oil fractionated
  • fluid unit dose forms are prepared containing a compound of the present invention and a sterile vehicle.
  • the compound depending on the vehicle and the concentration, can be either suspended or dissolved.
  • Parenteral solutions are normally prepared by dissolving the active compound in a vehicle and filter sterilising before filling into a suitable vial or ampoule and sealing.
  • adjuvants such as a local anaesthetic, preservatives and buffering agents are also dissolved in theNehicle.
  • the composition can be frozen after filling into the vial and the water removed under vacuum.
  • Parenteral suspensions are prepared in substantially the same manner except that the active compound is suspended in the vehicle instead of being dissolved and sterilised by exposure to ethylene oxide before suspending in the sterile vehicle.
  • a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the active compound.
  • compositions will usually be accompanied by written or printed directions for use in the medical treatment concerned.
  • pharmaceutically acceptable embraces compounds, compositions and ingredients for both human and veterinary use: for example the term 'pharmaceutically acceptable salt' embraces a veterinarily acceptable salt.
  • the present invention further provides a method for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, in a human or non-human mammal which comprises administering an effective, non-toxic, amount of Hydrobromide or solvate thereof to a human or non-human mammal in need thereof.
  • the active ingredient may be administered as a pharmaceutical composition hereinbefore defined, and this forms a particular aspect of the present invention.
  • the present invention provides the use of Hydrobromide or solvate thereof for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
  • the Hydrobromide or solvate thereof may be taken in amounts so as to provide Compound (I) in suitable doses, such as those disclosed in EP 0,306,228, WO94/05659 or WO98/55122.
  • Example 1 5-[4-[2-(N-methyl-N-(2-pyridyI)amino)ethoxy]benzyl]thiazolidine-2,4- dione hydrobromide
  • the solid state stability of the drug substance was determined by storing approximately 1.0 g of the material in a glass bottle at i) 40°C / 75% Relative Humidity (RH), open exposure, for 1 month and b) at 50°C, closed, for 1 month. The material was assayed by HPLC for final content and degradation products in both cases. a) 40°C / 75% RH: No significant degradation observed (HPLC assay 98% initial). b) 50°C: No significant degradation observed (HPLC assay 98% initial).
  • the ratio between the bulk density and the tapped bulk density (Hausner Ratio) of the Hydrobromide was determined using standard methods ("Pharmaceutics - The Science of Dosage Form Design", editor M. Aulton, 1988, published by:Churchill Livingstone). Hausner Ratio: 1.3
  • T onse t of the drug substance was determined by Differential Scanning Calorimetry using a Perkin-Elmer DSC7 apparatus. T onS e t : 182.5 o C
  • the melting point of the drug substance was determined visually by hot stage microscopy. Mpt: 181 °C
  • the IR spectrum of the solid product was recorded using a universal ATR accessory. Bands were observed at: 2929, 2859, 2749, 1745, 1694, 1641, 1608, 1543, 1514, 1445, 1419, 1382, 1358, 1326, 1311, 1287, 1255, 1240, 1202, 1184, 1148, 1070, 1053, 1031, 1014, 985, 906, 862, 844, 802, 768, 737, 710, 657 cm-l.
  • the Raman spectrum of the product ( Figure II) was recorded with the sample in an NMR tube using a Nicolet 960 E.S.P.
  • the XRPD pattern of the product ( Figure III) was recorded using the following acquisition conditions: Tube anode: Cu, Generator tension: 40 kN, Generator current: 40 mA, Start angle: 2.0 °2 ⁇ , End angle: 35.0 °2 ⁇ , Step size: 0.02 °2 ⁇ , Time per step: 2.5 seconds. Characteristic XRPD angles and relative intensities are recorded in Table 1.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

A novel pharmaceutical compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide or a solvate thereof, a process for preparing such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine.

Description

THIAZOLIDINEDIONE SALT FOR TREATMENT OF DIABETES MELLITUS
This invention relates to a novel pharmaceutical, to a process for the preparation of the pharmaceutical and to the use of the pharmaceutical in medicine. European Patent Application, Publication Number 0,306,228 relates to certain thiazolidinedione derivatives disclosed as having hypoglycaemic and hypolipidaemic activity. The compound of example 30 of EP 0,306,228 is 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (hereinafter also referred to as "Compound (I)"). International Patent Application, Publication Number WO94/05659 discloses certain salts of the compounds of EP 0,306,228 including salts formed from mineral acids such as hydrobromic, hydrochloric and sulphuric acids, and organic acids, such as methanesulphonic, tartaric and, in particular, maleic acid salts.
It has now been discovered that Compound (I) forms a novel hydrobromide salt (hereinafter also referred to as the "Hydrobromide") that is particularly stable and hence is suitable for bulk preparation and handling. The Hydrobromide also has a high melting point, shows particularly good aqueous solubility and possesses good bulk flow properties. The hydrobromide is therefore surprisingly amenable to large scale pharmaceutical processing and especially to large scale miling. The novel form can be prepared by an efficient, economic and reproducible process particularly suited to large-scale preparation.
The novel Hydrobromide also has useful pharmaceutical properties and in particular it is indicated to be useful for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof. Accordingly, the present invention provides 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide or a solvate thereof.
Suitably, the hydrobromide is a monohydrobromide.
In one favoured aspect, the Hydrobromide provides an infrared spectrum substantially in accordance with Figure I. In one favoured aspect, the Hydrobromide provides a Raman spectrum substantially in accordance with Figure II.
In one favoured aspect, the Hydrobromide provides an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table I or Figure III.
In one favoured aspect, the Hydrobromide provides a solid-state 13C NMR spectrum substantially in accordance with Figure IV.
It is also favoured that the Hydrobromide has a melting point within the range of from 175 to 185°C, especially 180 to 185°C, for example 181°C. Also the Hydrobromide has a Tonset within the range of from 180 to 186°C, for example 182.5°C.
Thus in a preferred aspect, the the Hydrobromide is characterised in that it provides two or more of: (i) an infrared spectrum substantially in accordance with Figure I; (ii) a Raman spectrum substantially in accordance with Figure II; (iii) an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table I or Figure III;
(iv) a solid-state 13C NMR spectrum substantially in accordance with Figure IN; and (v) a melting point within the range of from 175 to 185°C, especially 180 to 185°C, for example 181°C.
The present invention encompasses the Hydrobromide or solvate thereof isolated in pure form or when admixed with other materials. Thus in one aspect there is provided the Hydrobromide or solvate thereof in isolated form. In a further aspect there is provided the Hydrobromide or solvate thereof in a purified form.
In yet a further aspect there is provided the Hydrobromide or solvate thereof in crystalline form.
Also, the invention provides the Hydrobromide or solvate thereof in a solid pharmaceutically acceptable form, such as a solid dosage form, especially when adapted for oral administration.
Moreover, the invention also provides the Hydrobromide or solvate thereof in a pharmaceutically acceptable form, especially in bulk form, such form being particularly capable of being milled. Furthermore, the invention provides the Hydrobromide or solvate thereof in a pharmaceutically acceptable form, especially in bulk form, such form having good flow properties, especially good bulk flow properties. A suitable solvate is a hydrate.
The invention also provides a process for preparing the Hydrobromide or solvate thereof, characterised in that 5-[4-[2-(Ν-methyl-Ν-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (Compound(I)), or a salt thereof, preferably dispersed or dissolved in a suitable solvent, is reacted with a source of hydrogen bromide and thereafter, if required, a solvate of the Hydrobromide is prepared; and the Hydrobromide or solvate thereof is recovered. A suitable reaction solvent is an alkanol, for example propan-2-ol, or a hydrocarbon, such as toluene, a ketone, such as acetone, an ester, such as ethyl acetate, an ether such as tetrahydrofuran, a nitrile such as acetonitrile, or a halogenated hydrocarbon such as dichlorόmethane, water, or an organic acid such as acetic acid; or a mixture thereof.
Conveniently, the source of hydrogen bromide is provided by an aqueous solution of hydrogen bromide, for example a 48% w/w solution in water. Alternatively, the source of hydrogen bromide is a solution of hydrogen bromide in an appropriate solvent, optionally the reaction solvent, for example propan-2-ol. In addition, the hydrogen bromide may be added directly to a solution or suspension of Compound(I) in the chosen reaction solvent.
An alternative source of hydrogen bromide is provided by a base salt of hydrobromic acid for example ammonium bromide, or the hydrobromic acid salt of an amine, for example ethylamine or diethylamine.
The reaction is usually carried out at ambient temperature or at an elevated temperature, for example at the reflux temperature of the solvent, although any convenient temperature that provides the required product may be employed. Solvates, such as hydrates, of the Hydrobromide are prepared according to conventional procedures.
Recovery of the required compound generally comprises crystallisation from an appropriate solvent, conveniently the reaction solvent, usually by cooling to a temperature in the range of from 0°C to 60°C, for example 20 to 25°C or from 40 to 50°C. For example the Hydrobromide may be crystallised from an alcohol such as propan-2-ol or a ketone such as acetone.
In one preferred form the recovery comprises initial cooling to a first temperature, such as in the range of from 40 to 50°C, thereby allowing initiating crystallisation and thereafter cooling to a second temperature, suitably in the range of from 0 to 25°C. Crystallisation can also be initiated by seeding with crystals of the Hydrobromide or solvate thereof but this is not essential. Solvates are prepared by use of appropriate conventional methods.
Compound (I) is prepared according to known procedures, such as those disclosed in EP 0,306,228 and WO94/05659. The disclosures of EP 0,306,228 and WO94/05659 are incorporated herein by reference.
When used herein the term "Tonset" is generally determined by Differential Scanning Calorimetry and has a meaning generally understood in the art, as for example expressed in Pharmaceutical Thermal Analysis, Techniques and Applications", Ford and Timmins, 1989 as "The temperature corresponding to the intersection of the pre-transition baseline with the extrapolated leading edge of the transition" . When used herein in respect of certain compounds the term "good flow properties" is suitably characterised by the said compound having a Hausner ratio of less than or equal to 1.5, especially of less than or equal to 1.25.
"Hausner ratio" is an art accepted term. When used herein the term 'prophylaxis of conditions associated with diabetes mellitus' includes the treatment of conditions such as insulin resistance, impaired glucose tolerance, hyperinsulinaemia and gestational diabetes.
Diabetes mellitus preferably means Type II diabetes mellitus.
Conditions associated with diabetes include hyperglycaemia and insulin resistance and obesity. Further conditions associated with diabetes include hypertension, cardiovascular disease, especially atherosclerosis, certain eating disorders, in particular the regulation of appetite and food intake in subjects suffering from disorders associated with under-eating, such as anorexia nervosa, and disorders associated with over-eating, such as obesity and anorexia bulimia. Additional conditions associated with diabetes include polycystic ovarian syndrome and steroid induced insulin resistance.
The complications of conditions associated with diabetes mellitus encompassed herein includes renal disease, especially renal disease associated with the development of Type II diabetes including diabetic nephropathy, glomerulonephritis, glomerular sclerosis, nephrotic syndrome, hypertensive nephrosclerosis and end stage renal disease. As mentioned above the compound of the invention has useful therapeutic properties: The present invention accordingly provides the Hydrobromide or solvate thereof for use as an active therapeutic substance.
More particularly, the present invention provides the Hydrobromide or solvate thereof for use in the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
The Hydrobromide or solvate thereof may be administered per se or, preferably, as a pharmaceutical composition also comprising a pharmaceutically acceptable carrier. Suitable methods for formulating the Hydrobromide or solvate thereof are generally those disclosed for Compound (I) in the above mentioned publications. Accordingly, the present invention also provides a pharmaceutical composition comprising the Hydrobromide or solvate thereof and a pharmaceutically acceptable carrier therefor.
The Hydrobromide or solvate thereof is normally administered in unit dosage form. The active compound may be administered by any suitable route but usually by the oral or parenteral routes. For such use, the compound will normally be employed in the form of a pharmaceutical composition in association with a pharmaceutical carrier, diluent and/or excipient, although the exact form of the composition will naturally depend on the mode of administration.
Compositions are prepared by admixture and are suitably adapted for oral, parenteral or topical administration, and as such may be in the form of tablets, capsules, oral liquid preparations, powders, granules, lozenges, pastilles, reconstitutable powders, injectable and infusable solutions or suspensions, suppositories and transdermal devices.
Orally administrable compositions are preferred, in particular shaped oral compositions, since they are more convenient for general use.
Tablets and capsules for oral administration are usually presented in a unit dose, and contain conventional excipients such as binding agents, fillers, diluents, tabletting agents, lubricants, disintegrants, colourants, flavourings, and wetting agents. The tablets may be coated according to well known methods in the art.
Suitable fillers for use include cellulose, mannitol, lactose and other similar agents. Suitable disintegrants include starch, polyvinylpyrrolidone and starch derivatives such as sodium starch glycollate. Suitable lubricants include, for example, magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate.
Solid oral compositions may be prepared by conventional methods of blending, filling, tabletting or the like. Repeated blending operations may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are, of course, conventional in the art.
Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups, or elixirs, or may be presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; non-aqueous vehicles (which may include edible oils), for example, almond oil, fractionated coconut oil, oily esters such as esters of glycerine, propylene glycol, or ethyl alcohol; preservatives, for example methyl or propyl
£-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
For parenteral administration, fluid unit dose forms are prepared containing a compound of the present invention and a sterile vehicle. The compound, depending on the vehicle and the concentration, can be either suspended or dissolved. Parenteral solutions are normally prepared by dissolving the active compound in a vehicle and filter sterilising before filling into a suitable vial or ampoule and sealing. Advantageously, adjuvants such as a local anaesthetic, preservatives and buffering agents are also dissolved in theNehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum.
Parenteral suspensions are prepared in substantially the same manner except that the active compound is suspended in the vehicle instead of being dissolved and sterilised by exposure to ethylene oxide before suspending in the sterile vehicle. Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the active compound.
As is common practice, the compositions will usually be accompanied by written or printed directions for use in the medical treatment concerned. As used herein the term 'pharmaceutically acceptable' embraces compounds, compositions and ingredients for both human and veterinary use: for example the term 'pharmaceutically acceptable salt' embraces a veterinarily acceptable salt.
The present invention further provides a method for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, in a human or non-human mammal which comprises administering an effective, non-toxic, amount of Hydrobromide or solvate thereof to a human or non-human mammal in need thereof.
Conveniently, the active ingredient may be administered as a pharmaceutical composition hereinbefore defined, and this forms a particular aspect of the present invention.
In a further aspect the present invention provides the use of Hydrobromide or solvate thereof for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof. In the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof the Hydrobromide or solvate thereof may be taken in amounts so as to provide Compound (I) in suitable doses, such as those disclosed in EP 0,306,228, WO94/05659 or WO98/55122.
No adverse toxicological effects are indicated in the above mentioned treatments for the compounds of the invention.
The following examples illustrate the invention but do not limit it in any way. Example 1: 5-[4-[2-(N-methyl-N-(2-pyridyI)amino)ethoxy]benzyl]thiazolidine-2,4- dione hydrobromide
A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4- dione (1.0 g) and propan-2-ol (50 ml) was stirred and heated to reflux for a period of 10 minutes at which point a clear solution was observed. Hydrobromic acid (48% w/w solution in water, 0.31ml) was then added dropwise, and the reaction mixture stirred for 10 minutes at reflux then allowed to cool to 21°C. The product was collected by filtration and washed with propan-2-ol (10 ml) to give the 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide (0.41 g) as a white crystalline solid.
Example 2: 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4- dione hydrobromide
A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidineτ2,4- dione (3.0 g) and acetone (100 ml) was stirred and heated to reflux for a period of 15 minutes at which point a clear solution was observed.
Hydrobromic acid (48% w/w solution in water, 0.95 ml ) was added and the reaction mixture stirred at reflux for 15 minutes and then cooled to 21°C. After standing for 120 hours the mother liquor was decanted and the crystalline product washed with acetone (10 ml) and dried under vacuum for 3 hours to give 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dionehydrobromide (3.7 g) . 1H-NMR (d6-DMSO): consistent with 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide containing acetone, 0.5% wt/wt.
Example 3: 5-[4-[2-(N-methyI-N-(2-pyridyI)amino)ethoxy]benzyI]thiazoIidine-2,4- dione hydrobromide
A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4- dione (15.0 g) and acetone (230 ml) was stirred and heated to reflux for 15 minutes at which point a clear solution was observed. Hydrobromic acid (48% w/w aqueous solution, 4.75 ml) was then added and the mixture was cooled to 45 °C and stirred for 1 hour, and then cooled to 21 °C. The white solid was collected by filtration, and washed with acetone (100 ml) to give 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide (17.7 g) as a white crystalline solid.
CHARACTERISING DATA FOR THE HYDROBROMIDE
(1) RECORDED FOR THE PRODUCT OF EXAMPLE 3 Solubility of the Hydrobromide The solubility of the material was determined by adding water in aliquots from 1 to 1000ml to approximately lOOmg of drug substance until the powder had dissolved. The visual solubility was confirmed by an HPLC assay of a saturated solution. Solubility: 6mg/ml.
Solid State Stability of the Hydrobromide
The solid state stability of the drug substance was determined by storing approximately 1.0 g of the material in a glass bottle at i) 40°C / 75% Relative Humidity (RH), open exposure, for 1 month and b) at 50°C, closed, for 1 month. The material was assayed by HPLC for final content and degradation products in both cases. a) 40°C / 75% RH: No significant degradation observed (HPLC assay 98% initial). b) 50°C: No significant degradation observed (HPLC assay 98% initial).
Flow Properties of the Hydrobromide:
The ratio between the bulk density and the tapped bulk density (Hausner Ratio) of the Hydrobromide was determined using standard methods ("Pharmaceutics - The Science of Dosage Form Design", editor M. Aulton, 1988, published by:Churchill Livingstone). Hausner Ratio: 1.3
Tonset of the Hydrobromide
The Tonset of the drug substance was determined by Differential Scanning Calorimetry using a Perkin-Elmer DSC7 apparatus. TonSet: 182.5 oC
Melting Point of the Hydrobromide
The melting point of the drug substance was determined visually by hot stage microscopy. Mpt: 181 °C
(2) RECORDED FORTHE PRODUCT OF EXAMPLE 2
The infrared absorption spectrum of a mineral oil dispersion of the product was obtained using a Nicolet 710 FT-IR spectrometer at 2 cm-1 resolution (Figure I). Data were digitised at 1 cm-1 intervals. Bands were observed at:
2923, 2854, 2749, 1745, 1698, 1643, 1610, 1544, 1515, 1459, 1419, 1378, 1327, 1313, 1287, 1256, 1240, 1228, 1203, 1185, 1151, 1071, 1054, 1032, 1014, 985, 906, 803, 771, 738, 712, 524 cm"1.
The IR spectrum of the solid product was recorded using a universal ATR accessory. Bands were observed at: 2929, 2859, 2749, 1745, 1694, 1641, 1608, 1543, 1514, 1445, 1419, 1382, 1358, 1326, 1311, 1287, 1255, 1240, 1202, 1184, 1148, 1070, 1053, 1031, 1014, 985, 906, 862, 844, 802, 768, 737, 710, 657 cm-l.The Raman spectrum of the product (Figure II) was recorded with the sample in an NMR tube using a Nicolet 960 E.S.P. FT-Raman spectrometer, at 4 cm"1 resolution with excitation from a Nd:V04 laser (1064 nm) with a power output of 400mW. Bands were observed at: 3067, 2997, 2926, 2884, 2860, 1747, 1611, 1588, 1545, 1445, 1382, 1360, 1315, 1287, 1240, 1213, 1185, 1070, 1016, 986, 917, 826, 769, 740, 712, 659, 636, 620, 605, 506, 470, 405, 332,303,134,99 cm"1.
The XRPD pattern of the product (Figure III) was recorded using the following acquisition conditions: Tube anode: Cu, Generator tension: 40 kN, Generator current: 40 mA, Start angle: 2.0 °2Θ, End angle: 35.0 °2Θ, Step size: 0.02 °2Θ , Time per step: 2.5 seconds. Characteristic XRPD angles and relative intensities are recorded in Table 1.
Table 1

Claims

CLAIMS:
1. A compound 5-[4-[2-(N-memyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine- 2,4-dione hydrobromide or a solvate thereof.
2. A compound according to claim 1 , characterised in that it provides two or more of:
(i) an infrared spectrum substantially in accordance with Figure I;
(ii) a Raman spectrum substantially in accordance with Figure II; (iii) an X-Ray powder diffraction pattern (XRPD) substantially in accordance with
Table I or Figure III;
(iv) a solid-state 13C NMR spectrum substantially in accordance with Figure IV; and
(v) a melting point within the range of from 175 to 185°C, especially 180 to 185°C, for example 181°C.
3. A compound according to claim 1 or claim 2, in purified form.
4. A compound according to any one of claims 1 to 3, in a solid dosage form.
5. A compound according to any one of claims 1 to 3, in a pharmaceutically acceptable form capable of being milled.
6. A compound according to any one of claims 1 to 3, in a pharmaceutically acceptable form having good flow properties.
7. A process for preparing the 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide or a solvate thereof. characterised in that 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine- 2,4-dione or a salt thereof is reacted with a source of hydrogen bromide and thereafter, if required, a solvate of the Hydrobromide is prepared; and the Hydrobromide or solvate thereof is recovered.
8. A pharmaceutical composition comprising 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide or a solvate thereof. and a pharmaceutically acceptable carrier therefor.
9. A compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine- 2,4-dione hydrobromide or a solvate thereof for use as an active therapeutic substance.
10. A use of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4- dione hydrobromide or a solvate thereof, for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
EP01938400A 2000-06-08 2001-06-08 Thiazolidinedione salt for treatment of diabetes mellitus Withdrawn EP1296980A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0014006.1A GB0014006D0 (en) 2000-06-08 2000-06-08 Novel pharmaceutical
GB0014006 2000-06-08
PCT/GB2001/002567 WO2001094344A1 (en) 2000-06-08 2001-06-08 Thiazolidinedione salt for treatment of diabetes mellitus

Publications (1)

Publication Number Publication Date
EP1296980A1 true EP1296980A1 (en) 2003-04-02

Family

ID=9893257

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01938400A Withdrawn EP1296980A1 (en) 2000-06-08 2001-06-08 Thiazolidinedione salt for treatment of diabetes mellitus

Country Status (23)

Country Link
EP (1) EP1296980A1 (en)
JP (1) JP2003535862A (en)
KR (1) KR20030007918A (en)
CN (1) CN1443186A (en)
AP (1) AP2002002673A0 (en)
AU (1) AU2001264078A1 (en)
BG (1) BG107357A (en)
BR (1) BR0111536A (en)
CA (1) CA2411065A1 (en)
CZ (1) CZ20023966A3 (en)
DZ (1) DZ3382A1 (en)
EA (1) EA200300005A1 (en)
GB (1) GB0014006D0 (en)
HU (1) HUP0301137A3 (en)
IL (1) IL153279A0 (en)
MA (1) MA25753A1 (en)
MX (1) MXPA02012100A (en)
NO (1) NO20025883L (en)
OA (1) OA12284A (en)
PL (1) PL360592A1 (en)
SK (1) SK17142002A3 (en)
WO (1) WO2001094344A1 (en)
ZA (1) ZA200209954B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39384E1 (en) 1993-09-01 2006-11-07 Smithkline Beecham P.L.C. Substituted thiazolidinedione derivatives
DE102005034406A1 (en) * 2005-07-22 2007-02-01 Ratiopharm Gmbh New salts of rosiglitazone
WO2008091624A2 (en) * 2007-01-22 2008-07-31 Teva Pharmaceutical Industries Ltd. Polymorphic forms of rosiglitazone hydrobromide and processes for preparation thereof
EP1956018A1 (en) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Method of preparing a derivative of benzimidazole
WO2010021745A2 (en) * 2008-08-21 2010-02-25 Teva Pharmaceutical Industries Ltd. Polymorphic forms of rosiglitazone hydrobromide and processes for their preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0194344A1 *

Also Published As

Publication number Publication date
GB0014006D0 (en) 2000-08-02
BR0111536A (en) 2003-07-01
CZ20023966A3 (en) 2003-04-16
AP2002002673A0 (en) 2002-12-31
NO20025883L (en) 2003-02-03
JP2003535862A (en) 2003-12-02
EA200300005A1 (en) 2003-04-24
NO20025883D0 (en) 2002-12-06
IL153279A0 (en) 2003-07-06
HUP0301137A2 (en) 2003-08-28
WO2001094344A1 (en) 2001-12-13
ZA200209954B (en) 2003-10-10
PL360592A1 (en) 2004-09-20
AU2001264078A1 (en) 2001-12-17
BG107357A (en) 2003-08-29
DZ3382A1 (en) 2001-12-13
OA12284A (en) 2003-11-10
CN1443186A (en) 2003-09-17
MA25753A1 (en) 2003-04-01
CA2411065A1 (en) 2001-12-13
MXPA02012100A (en) 2003-04-25
SK17142002A3 (en) 2003-10-07
KR20030007918A (en) 2003-01-23
HUP0301137A3 (en) 2005-04-28

Similar Documents

Publication Publication Date Title
EP1305312B1 (en) Tartrate salts of thiazolidinedione derivative
EP1349855A1 (en) 5-'4-'2-(n-methyl-n- (2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione mesylate salt
WO2001094344A1 (en) Thiazolidinedione salt for treatment of diabetes mellitus
CA2421213A1 (en) The hydrochloride salt of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
EP1305311B1 (en) Tartrate salt of thiazolidinedione derivative
EP1446404A1 (en) Rosiglitazone edisylates and their use as antidiabetics
US20040014791A1 (en) Thiazolidinedione derivative and its use as antidiabetic
AU2001262550B2 (en) 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyl)thiazolidine-2,4-dione hydriodide as pharmaceutical
WO2002020520A1 (en) A thiazolidinedione derivative and its use as antidiabetic
EP1305310B1 (en) Tartrate salts of thiazolidinedione derivative
AU2001292034B2 (en) A thiazolidinedione derivative and its use as antidiabetic
US20030162815A1 (en) Thiazolidinedione salt for treatment of diabetes mellitus
AU2001262550A1 (en) 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyl)thiazolidine-2,4-dione hydriodide as pharmaceutical
AU2001292034A1 (en) A thiazolidinedione derivative and its use as antidiabetic

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030106

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060103

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1056551

Country of ref document: HK