EE03523B1 - Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine - Google Patents

Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine

Info

Publication number
EE03523B1
EE03523B1 EE9800223A EE9800223A EE03523B1 EE 03523 B1 EE03523 B1 EE 03523B1 EE 9800223 A EE9800223 A EE 9800223A EE 9800223 A EE9800223 A EE 9800223A EE 03523 B1 EE03523 B1 EE 03523B1
Authority
EE
Estonia
Prior art keywords
phenanthridines
drugs containing
compounds
formula
description
Prior art date
Application number
EE9800223A
Other languages
English (en)
Estonian (et)
Other versions
EE9800223A (et
Inventor
Gutterer Beate
Amschler Hermann
Flockerzi Dieter
Ulrich Wolf-R�diger
B�r Thomas
Martin Thomas
Schudt Christian
Hatzelmann Armin
Beume Rolf
H�fner Dietrich
Boss Hildegard
Kley Hans-Peter
Goebel Karl-Josef
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19603321A external-priority patent/DE19603321A1/de
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9800223A publication Critical patent/EE9800223A/xx
Publication of EE03523B1 publication Critical patent/EE03523B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EE9800223A 1996-01-31 1997-01-30 Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine EE03523B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19603321A DE19603321A1 (de) 1996-01-31 1996-01-31 Neue Phenanthridine
EP96101791 1996-02-08
PCT/EP1997/000402 WO1997028131A1 (de) 1996-01-31 1997-01-30 Neue phenanthridine

Publications (2)

Publication Number Publication Date
EE9800223A EE9800223A (et) 1998-12-15
EE03523B1 true EE03523B1 (et) 2001-10-15

Family

ID=26022482

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800223A EE03523B1 (et) 1996-01-31 1997-01-30 Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine

Country Status (19)

Country Link
US (1) US6191138B1 (pt)
EP (1) EP0882021B1 (pt)
JP (1) JP4138003B2 (pt)
KR (1) KR100454781B1 (pt)
AT (1) ATE233735T1 (pt)
BR (1) BR9707233A (pt)
CA (1) CA2245142C (pt)
CY (1) CY2473B1 (pt)
CZ (1) CZ289340B6 (pt)
DE (1) DE59709437D1 (pt)
DK (1) DK0882021T3 (pt)
EA (1) EA001205B1 (pt)
EE (1) EE03523B1 (pt)
ES (1) ES2194180T3 (pt)
HU (1) HU221380B1 (pt)
PT (1) PT882021E (pt)
SI (1) SI0882021T1 (pt)
UA (1) UA48216C2 (pt)
WO (1) WO1997028131A1 (pt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2245142C (en) * 1996-01-31 2004-11-30 Byk Gulden Lomberg Chemische Fabrik Gmbh New phenanthridines
PT1000035E (pt) * 1997-07-25 2003-04-30 Altana Pharma Ag 6-fenilfenantridinas substituidas
US6410551B1 (en) * 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
JP2002534505A (ja) * 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規フェナントリジン−ｎ−オキシド
JP2002534507A (ja) * 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規６−アリールフェナントリジン
NZ512872A (en) * 1999-01-15 2003-07-25 Altana Pharma Ag Phenylphenanthridines with PDE-IV inhibiting activity
PT1147103E (pt) 1999-01-15 2005-08-31 Altana Pharma Ag Fenantridina-n-oxidos com actividade inibitoria de pde-iv
CA2360386A1 (en) * 1999-01-15 2000-07-20 Beate Gutterer Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
AU782908B2 (en) 2000-01-11 2005-09-08 Altana Pharma Ag Phenanthridine-N-oxides
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
SI1303506T1 (en) 2000-07-14 2005-06-30 Altana Pharma Ag 6-heteroarylphenanthridines
AU2001269126A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Phenanthridine n-oxides
AU2001267589A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
KR100610131B1 (ko) * 2000-09-06 2006-08-09 다나베 세이야꾸 가부시키가이샤 경구 투여용 제제
CA2437754C (en) * 2001-02-15 2010-05-18 Tanabe Seiyaku Co., Ltd. Tablets quickly disintegrated in oral cavity
US20060116518A1 (en) * 2002-08-17 2006-06-01 Altana Pharma Ag Novel phenanthridines
ES2279215T3 (es) 2002-08-29 2007-08-16 Altana Pharma Ag 2-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
JP4587295B2 (ja) * 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン
JP2007500686A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
CA2533635A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
MXPA06002521A (es) * 2003-09-05 2006-06-20 Altana Pharma Ag Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus.
WO2005077906A1 (en) * 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
DK1723135T5 (da) 2004-03-03 2013-09-16 Takeda Gmbh Ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som pde4-inhibitorer
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
KR20060124784A (ko) * 2004-03-09 2006-12-05 알타나 파마 아게 신규한 이소아미도 치환된 히드록시-6-페닐페난트리딘 및ｐｄｅ４ 억제제로서의 이의 용도
BRPI0508471A8 (pt) * 2004-03-10 2019-01-15 Altana Pharma Ag compostos de hidróxi-6-fenilfenantidinas substituídas por difluoroetóxi, composição farmacêutica e uso para a produção dos mesmos
AU2005221832A1 (en) * 2004-03-10 2005-09-22 Nycomed Gmbh Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
KR20060124783A (ko) * 2004-03-10 2006-12-05 알타나 파마 아게 신규 티오-함유 히드록시-6-페닐페난트리딘 및 ｐｄｅ４억제제로서의 이의 용도
ES2365926T3 (es) * 2004-09-08 2011-10-13 Nycomed Gmbh 3-oxa-10-aza-fenantrenos como inhibidores de pde4 o pde3/4.
WO2006027345A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
US7411093B2 (en) * 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
MX2007010400A (es) 2005-03-02 2008-01-11 Nycomed Gmbh Nuevas sales de derivados de hexahidrofenantridina sustituida con 6-heterociclilo.
AU2006222060B2 (en) 2005-03-08 2011-09-01 Takeda Gmbh Roflumilast for the treatment of diabetes mellitus
EP1858880A1 (en) * 2005-03-09 2007-11-28 Nycomed GmbH Amido-substituted 6-phenylphenanthridines
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007104035A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) * 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
KR101067069B1 (ko) * 2009-03-09 2011-09-22 부경대학교 산학협력단 트리플루오로아세트산을 이용한 페난트리딘 유도체의 제조방법
CN102179655B (zh) * 2011-06-01 2013-09-04 柳州市久日工程机械有限公司 履带梁拼搭气动工装
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
JP7234470B2 (ja) 2015-10-30 2023-03-08 トーヨーカネツ株式会社 立体自動倉庫

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786031A (fr) * 1971-07-08 1973-01-08 Rhone Poulenc Sa Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof
CA2245142C (en) * 1996-01-31 2004-11-30 Byk Gulden Lomberg Chemische Fabrik Gmbh New phenanthridines

Also Published As

Publication number Publication date
CZ241498A3 (cs) 1998-12-16
HUP9900666A3 (en) 2000-04-28
JP2000503996A (ja) 2000-04-04
KR100454781B1 (ko) 2005-04-08
KR19990082143A (ko) 1999-11-15
HU221380B1 (en) 2002-09-28
EA001205B1 (ru) 2000-12-25
HUP9900666A2 (hu) 1999-06-28
DK0882021T3 (da) 2003-06-23
CA2245142C (en) 2004-11-30
EA199800667A1 (ru) 1999-02-25
EE9800223A (et) 1998-12-15
UA48216C2 (uk) 2002-08-15
SI0882021T1 (en) 2003-10-31
EP0882021B1 (de) 2003-03-05
WO1997028131A1 (de) 1997-08-07
EP0882021A1 (de) 1998-12-09
ATE233735T1 (de) 2003-03-15
ES2194180T3 (es) 2003-11-16
US6191138B1 (en) 2001-02-20
JP4138003B2 (ja) 2008-08-20
PT882021E (pt) 2003-07-31
CA2245142A1 (en) 1997-08-07
CZ289340B6 (cs) 2002-01-16
CY2473B1 (en) 2005-06-03
DE59709437D1 (de) 2003-04-10
BR9707233A (pt) 1999-07-20

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