PT1147103E - Fenantridina-n-oxidos com actividade inibitoria de pde-iv - Google Patents

Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Info

Publication number
PT1147103E
PT1147103E PT00901539T PT00901539T PT1147103E PT 1147103 E PT1147103 E PT 1147103E PT 00901539 T PT00901539 T PT 00901539T PT 00901539 T PT00901539 T PT 00901539T PT 1147103 E PT1147103 E PT 1147103E
Authority
PT
Portugal
Prior art keywords
oxides
fenantridine
pde
inhibitors activity
inhibitors
Prior art date
Application number
PT00901539T
Other languages
English (en)
Inventor
Rolf Beume
Hildegard Boss
Dieter Flockerzi
Beate Schmidt
Armin Hatzelmann
Hermann Amschler
Kley Hans-Peter
Bundschuh Daniela
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of PT1147103E publication Critical patent/PT1147103E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Pyridine Compounds (AREA)
PT00901539T 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv PT1147103E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15

Publications (1)

Publication Number Publication Date
PT1147103E true PT1147103E (pt) 2005-08-31

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00901539T PT1147103E (pt) 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Country Status (12)

Country Link
US (1) US6534519B1 (pt)
EP (1) EP1147103B1 (pt)
JP (1) JP2003502278A (pt)
AT (1) ATE294793T1 (pt)
AU (1) AU2290000A (pt)
CA (1) CA2359449A1 (pt)
DE (1) DE60019894T2 (pt)
DK (1) DK1147103T3 (pt)
ES (1) ES2241571T3 (pt)
PT (1) PT1147103E (pt)
SI (1) SI1147103T1 (pt)
WO (1) WO2000042034A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60024581T2 (de) * 1999-01-15 2006-08-10 Altana Pharma Ag 6-phenylphenanthridine mit pde-iv hemmender wirkung
US6630483B2 (en) 2000-01-11 2003-10-07 Altana Pharma Ag Phenanthridine-N-oxides
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
DE60310576T2 (de) * 2002-08-29 2007-10-31 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
AU2003273805B8 (en) 2002-08-29 2010-06-17 Takeda Gmbh 3-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
JP2007500686A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
JP2007500685A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
MXPA06002521A (es) * 2003-09-05 2006-06-20 Altana Pharma Ag Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus.
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
ES2505473T3 (es) 2004-03-03 2014-10-10 Takeda Gmbh Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la PDE4
KR20060130697A (ko) * 2004-03-10 2006-12-19 알타나 파마 아게 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
US7718668B2 (en) 2005-03-02 2010-05-18 Nycomed Gmbh Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives
KR101302838B1 (ko) 2005-03-08 2013-09-03 다케다 게엠베하 진성 당뇨병 치료용 로플루밀라스트
WO2009043784A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
DK0882021T3 (da) * 1996-01-31 2003-06-23 Altana Pharma Ag Nye phenanthridiner
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
WO1997035854A1 (de) * 1996-03-26 1997-10-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue in 6-position substituierte phenanthridine
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
EA001551B1 (ru) 1996-11-11 2001-04-23 Бык Гюльден Ломберг Хемише Фабрик Гмбх Бензонафтиридины в качестве бронхиальных терапевтических средств
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
DK0968211T3 (da) 1997-03-07 2003-12-08 Altana Pharma Ag Tetrazolderivater
JP2002502403A (ja) 1997-06-03 2002-01-22 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ベンゾナフチリジン
DE69822162T2 (de) 1997-07-25 2005-01-27 Altana Pharma Ag Neue tetrazolderivate
JP2002523505A (ja) 1998-08-31 2002-07-30 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド

Also Published As

Publication number Publication date
ATE294793T1 (de) 2005-05-15
DE60019894D1 (de) 2005-06-09
EP1147103A1 (en) 2001-10-24
CA2359449A1 (en) 2000-07-20
DE60019894T2 (de) 2006-01-12
US6534519B1 (en) 2003-03-18
DK1147103T3 (da) 2005-08-29
EP1147103B1 (en) 2005-05-04
AU2290000A (en) 2000-08-01
WO2000042034A1 (en) 2000-07-20
SI1147103T1 (en) 2005-10-31
JP2003502278A (ja) 2003-01-21
ES2241571T3 (es) 2005-11-01

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