EA201500316A1 - Антагонисты толл-подобного рецептора 3 - Google Patents
Антагонисты толл-подобного рецептора 3Info
- Publication number
- EA201500316A1 EA201500316A1 EA201500316A EA201500316A EA201500316A1 EA 201500316 A1 EA201500316 A1 EA 201500316A1 EA 201500316 A EA201500316 A EA 201500316A EA 201500316 A EA201500316 A EA 201500316A EA 201500316 A1 EA201500316 A1 EA 201500316A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- toll
- receptor
- antagonists
- tlr3
- antagonist antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
Abstract
Описываются антитела-антагонисты толл-подобного рецептора 3 (TLR3), полинуклеотиды, кодирующие антитела-антагонисты TLR3 или их фрагменты, и способы изготовления и применения вышеуказанных веществ.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10997408P | 2008-10-31 | 2008-10-31 | |
US16186009P | 2009-03-20 | 2009-03-20 | |
US16510009P | 2009-03-31 | 2009-03-31 | |
US17368609P | 2009-04-29 | 2009-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201500316A1 true EA201500316A1 (ru) | 2016-01-29 |
Family
ID=42129569
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170636A EA022832B1 (ru) | 2008-10-31 | 2009-10-30 | Выделенное антитело, способное взаимодействовать с tlr3 |
EA201500316A EA201500316A1 (ru) | 2008-10-31 | 2009-10-30 | Антагонисты толл-подобного рецептора 3 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170636A EA022832B1 (ru) | 2008-10-31 | 2009-10-30 | Выделенное антитело, способное взаимодействовать с tlr3 |
Country Status (33)
Country | Link |
---|---|
US (8) | US8409567B2 (ru) |
EP (1) | EP2350304B1 (ru) |
JP (1) | JP5751631B2 (ru) |
KR (1) | KR101683033B1 (ru) |
CN (2) | CN105601742A (ru) |
AU (1) | AU2009308763B2 (ru) |
BR (1) | BRPI0921696A2 (ru) |
CA (1) | CA2742014A1 (ru) |
CL (1) | CL2011000975A1 (ru) |
CO (1) | CO6362052A2 (ru) |
CY (1) | CY1118797T1 (ru) |
DK (1) | DK2350304T3 (ru) |
EA (2) | EA022832B1 (ru) |
EC (1) | ECSP11011072A (ru) |
ES (1) | ES2618567T3 (ru) |
HK (1) | HK1166105A1 (ru) |
HR (1) | HRP20170415T1 (ru) |
HU (1) | HUE031756T2 (ru) |
IL (1) | IL212545A (ru) |
LT (1) | LT2350304T (ru) |
MX (1) | MX2011004635A (ru) |
MY (1) | MY183144A (ru) |
NI (1) | NI201100085A (ru) |
NZ (2) | NZ603824A (ru) |
PE (1) | PE20110808A1 (ru) |
PL (1) | PL2350304T3 (ru) |
PT (1) | PT2350304T (ru) |
RS (1) | RS55861B1 (ru) |
SI (1) | SI2350304T1 (ru) |
SM (1) | SMT201700127B (ru) |
SV (1) | SV2011003891A (ru) |
UA (1) | UA109397C2 (ru) |
WO (1) | WO2010051470A2 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130090457A1 (en) * | 2008-10-31 | 2013-04-11 | Janssen Biotech, Inc. | Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases |
US8460659B2 (en) | 2008-10-31 | 2013-06-11 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
AU2009308763B2 (en) | 2008-10-31 | 2017-03-09 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
EA021512B1 (ru) * | 2009-04-29 | 2015-07-30 | Янссен Байотек Инк. | Антагонисты толл-подобного рецептора 3 |
WO2011004028A2 (en) | 2009-07-10 | 2011-01-13 | Innate Pharma | Tlr3 binding agents |
AU2012206614A1 (en) | 2011-01-12 | 2013-08-01 | Innate Pharma | TLR3 binding agents |
CA2855955A1 (en) * | 2011-09-12 | 2013-03-21 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
MX361773B (es) | 2012-05-31 | 2018-12-17 | Innate Pharma | Agentes de ligación a tlr3. |
EP3560960A1 (en) * | 2013-04-22 | 2019-10-30 | The University of Tokyo | Preventive or therapeutic agent for inflammatory disease |
US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
WO2015016282A1 (ja) * | 2013-07-30 | 2015-02-05 | 国立大学法人東京大学 | 放射線誘導性消化管症候群の予防又は治療用医薬組成物 |
GB201522394D0 (en) * | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
BR112018014810A2 (pt) | 2016-01-22 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-fator xi de coagulação |
AR108717A1 (es) | 2016-06-14 | 2018-09-19 | Merck Sharp & Dohme | Anticuerpos antifactor de la coagulación xi |
US10429214B2 (en) * | 2017-03-07 | 2019-10-01 | Newtonoid Technologies, L.L.C. | Modular elongated wall-mounted sensor system and method |
CN109136231B (zh) * | 2018-09-14 | 2019-08-30 | 苏州大学 | 一种翘嘴鳜tlr3基因及其应用 |
WO2023235771A2 (en) * | 2022-05-31 | 2023-12-07 | The University Of Chicago | Chemical screen of modulators for vaccine adjuvants |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
CA2461315A1 (en) * | 2001-10-05 | 2003-04-17 | Coley Pharmaceutical Gmbh | Toll-like receptor 3 signaling agonists and antagonists |
JP2004016021A (ja) * | 2002-06-12 | 2004-01-22 | Japan Science & Technology Corp | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
BRPI0411514A (pt) | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
CA2483732A1 (en) | 2004-09-29 | 2006-03-29 | Ronan Le Goffic | Toll-like receptor 3, its signalling associated molecule trif and their use thereof |
TWI487535B (zh) * | 2004-11-30 | 2015-06-11 | Centocor Inc | 類鐸受體3(toll like receptor3)拮抗劑,方法及用途 |
UA97229C2 (ru) * | 2004-11-30 | 2012-01-25 | Центокор, Инк. | Изолированное моноклональное антитело, которое специфически связывается с toll-подобным рецептором 3 (tlr3) |
ES2435775T3 (es) * | 2005-10-27 | 2013-12-23 | Janssen Biotech, Inc. | Moduladores de receptor tipo Toll 3, procedimientos y usos |
US20100183638A1 (en) * | 2007-03-05 | 2010-07-22 | Gowen Brian B | Restrictive agonist of toll-like receptor 3 (tlr3) |
EP2155889A4 (en) | 2007-05-25 | 2010-06-16 | Centocor Ortho Biotech Inc | TOLL RECEPTOR 3 MODULATORS AND USES THEREOF |
US8273541B2 (en) | 2008-09-17 | 2012-09-25 | Innate Pharma | Compositions and methods for detecting TLR3 |
WO2010040054A2 (en) | 2008-10-02 | 2010-04-08 | Centocor Ortho Biotech Inc. | Methods for suppressing toll-like receptor activity |
AU2009308763B2 (en) | 2008-10-31 | 2017-03-09 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
US20100188778A1 (en) * | 2009-01-29 | 2010-07-29 | Castagna Joseph T | Disk Drive Assembly Having Flexible Support for Flexible Printed Circuit Board |
EA021512B1 (ru) | 2009-04-29 | 2015-07-30 | Янссен Байотек Инк. | Антагонисты толл-подобного рецептора 3 |
WO2011004028A2 (en) * | 2009-07-10 | 2011-01-13 | Innate Pharma | Tlr3 binding agents |
-
2009
- 2009-10-30 AU AU2009308763A patent/AU2009308763B2/en not_active Ceased
- 2009-10-30 US US12/609,675 patent/US8409567B2/en not_active Expired - Fee Related
- 2009-10-30 CN CN201610006370.5A patent/CN105601742A/zh active Pending
- 2009-10-30 ES ES09824182.1T patent/ES2618567T3/es active Active
- 2009-10-30 PL PL09824182T patent/PL2350304T3/pl unknown
- 2009-10-30 BR BRPI0921696-0A patent/BRPI0921696A2/pt not_active Application Discontinuation
- 2009-10-30 WO PCT/US2009/062813 patent/WO2010051470A2/en active Application Filing
- 2009-10-30 EP EP09824182.1A patent/EP2350304B1/en active Active
- 2009-10-30 MX MX2011004635A patent/MX2011004635A/es active IP Right Grant
- 2009-10-30 PT PT98241821T patent/PT2350304T/pt unknown
- 2009-10-30 CA CA2742014A patent/CA2742014A1/en not_active Abandoned
- 2009-10-30 UA UAA201106797A patent/UA109397C2/uk unknown
- 2009-10-30 LT LTEP09824182.1T patent/LT2350304T/lt unknown
- 2009-10-30 DK DK09824182.1T patent/DK2350304T3/en active
- 2009-10-30 JP JP2011534819A patent/JP5751631B2/ja not_active Expired - Fee Related
- 2009-10-30 CN CN200980153815.0A patent/CN102300997B/zh not_active Expired - Fee Related
- 2009-10-30 EA EA201170636A patent/EA022832B1/ru not_active IP Right Cessation
- 2009-10-30 RS RS20170263A patent/RS55861B1/sr unknown
- 2009-10-30 NZ NZ603824A patent/NZ603824A/xx not_active IP Right Cessation
- 2009-10-30 NZ NZ592542A patent/NZ592542A/xx not_active IP Right Cessation
- 2009-10-30 KR KR1020117012075A patent/KR101683033B1/ko active IP Right Grant
- 2009-10-30 MY MYPI2011001876A patent/MY183144A/en unknown
- 2009-10-30 PE PE2011000964A patent/PE20110808A1/es not_active Application Discontinuation
- 2009-10-30 HU HUE09824182A patent/HUE031756T2/en unknown
- 2009-10-30 EA EA201500316A patent/EA201500316A1/ru unknown
- 2009-10-30 SI SI200931604A patent/SI2350304T1/sl unknown
-
2010
- 2010-04-29 US US12/770,147 patent/US8540986B2/en not_active Expired - Fee Related
-
2011
- 2011-04-28 IL IL212545A patent/IL212545A/en not_active IP Right Cessation
- 2011-04-29 CL CL2011000975A patent/CL2011000975A1/es unknown
- 2011-04-29 NI NI201100085A patent/NI201100085A/es unknown
- 2011-04-30 SV SV2011003891A patent/SV2011003891A/es unknown
- 2011-05-12 CO CO11058446A patent/CO6362052A2/es active IP Right Grant
- 2011-05-23 EC EC2011011072A patent/ECSP11011072A/es unknown
-
2012
- 2012-06-13 HK HK12105768.5A patent/HK1166105A1/zh not_active IP Right Cessation
-
2013
- 2013-01-28 US US13/751,718 patent/US9481731B2/en not_active Expired - Fee Related
- 2013-02-26 US US13/777,513 patent/US9255153B2/en not_active Expired - Fee Related
- 2013-03-13 US US13/798,494 patent/US9238693B2/en not_active Expired - Fee Related
- 2013-08-22 US US13/973,187 patent/US9522957B2/en not_active Expired - Fee Related
-
2016
- 2016-11-08 US US15/345,860 patent/US9932404B2/en not_active Expired - Fee Related
-
2017
- 2017-02-24 SM SM201700127T patent/SMT201700127B/it unknown
- 2017-03-13 HR HRP20170415TT patent/HRP20170415T1/hr unknown
- 2017-03-14 CY CY20171100323T patent/CY1118797T1/el unknown
-
2018
- 2018-02-15 US US15/898,112 patent/US20180179294A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201500316A1 (ru) | Антагонисты толл-подобного рецептора 3 | |
EA201171307A1 (ru) | Антагонисты толл-подобного рецептора 3 | |
EA200701192A1 (ru) | Антагонисты toll-подобного рецептора 3, способы их получения и применение | |
BRPI0506679A (pt) | métodos de tratar osteoartrite com antagonistas de il-6 | |
EA201290254A1 (ru) | Антагонисты il-17a | |
CU24058B1 (es) | Antagonistas de pcsk9 | |
EA200870409A1 (ru) | Антагонисты киназы pi3 | |
ATE469895T1 (de) | Cgrp-rezeptorantagonisten | |
EA201100300A1 (ru) | Композиции и способы, предназначенные для направленного воздействия антител на белок c5 системы комплемента | |
MA34520B1 (fr) | Anticorps se liant à la myostatine, compositions et procédés | |
UY32501A (es) | Anticuerpo antagonista específico para el heterodímero alfa4-beta7 | |
MY156315A (en) | Anti-vegf antibodies | |
EA201101009A1 (ru) | АНТАГОНИСТЫ C5aR | |
EA201201435A1 (ru) | ГЕТЕРОДИМЕРНЫЕ АНТИТЕЛО-Fc-СОДЕРЖАЩИЕ БЕЛКИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ | |
ATE512366T1 (de) | Ms-verfahren zur evaluierung von glycanen | |
DK1773885T3 (da) | Humaniserede anti-c-met-antagonister | |
DE602006006200D1 (de) | Antikörper gegen 25-hydroxyvitamin d | |
EA201100868A1 (ru) | Противоопухолевые комбинации, содержащие антитела, специфически распознающие cd38, и цитарабин | |
MX2009008104A (es) | Hepcidina, antagonistas de hepcidina y metodos de uso. | |
EA201170030A1 (ru) | Il-6-опосредованная иммунотерапия | |
MX2010004374A (es) | Armazones proteinicos. | |
DK2064348T3 (da) | Profilering af receptorfamilie | |
ATE554769T1 (de) | Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon | |
MX2011010012A (es) | NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS. | |
EA201101152A1 (ru) | Лиофилизированный дабигатран |