EA201500316A1 - Антагонисты толл-подобного рецептора 3 - Google Patents

Антагонисты толл-подобного рецептора 3

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Publication number
EA201500316A1
EA201500316A1 EA201500316A EA201500316A EA201500316A1 EA 201500316 A1 EA201500316 A1 EA 201500316A1 EA 201500316 A EA201500316 A EA 201500316A EA 201500316 A EA201500316 A EA 201500316A EA 201500316 A1 EA201500316 A1 EA 201500316A1
Authority
EA
Eurasian Patent Office
Prior art keywords
toll
receptor
antagonists
tlr3
antagonist antibodies
Prior art date
Application number
EA201500316A
Other languages
English (en)
Inventor
Марк Каннингхэм
Лани Сан Матео
Роберт Т. Сариски
Рэймонд Свит
Роберт Раухенбергер
Марк Рутц
Ицин Фэн
Катарина Херинга
Цзиньцюань Ло
Фан Тэн
Алексей Тепляков
Шэн-Дзюн Ву
Original Assignee
Сентокор Орто Байотек Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентокор Орто Байотек Инк. filed Critical Сентокор Орто Байотек Инк.
Publication of EA201500316A1 publication Critical patent/EA201500316A1/ru

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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Описываются антитела-антагонисты толл-подобного рецептора 3 (TLR3), полинуклеотиды, кодирующие антитела-антагонисты TLR3 или их фрагменты, и способы изготовления и применения вышеуказанных веществ.
EA201500316A 2008-10-31 2009-10-30 Антагонисты толл-подобного рецептора 3 EA201500316A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10997408P 2008-10-31 2008-10-31
US16186009P 2009-03-20 2009-03-20
US16510009P 2009-03-31 2009-03-31
US17368609P 2009-04-29 2009-04-29

Publications (1)

Publication Number Publication Date
EA201500316A1 true EA201500316A1 (ru) 2016-01-29

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201170636A EA022832B1 (ru) 2008-10-31 2009-10-30 Выделенное антитело, способное взаимодействовать с tlr3
EA201500316A EA201500316A1 (ru) 2008-10-31 2009-10-30 Антагонисты толл-подобного рецептора 3

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201170636A EA022832B1 (ru) 2008-10-31 2009-10-30 Выделенное антитело, способное взаимодействовать с tlr3

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US (8) US8409567B2 (ru)
EP (1) EP2350304B1 (ru)
JP (1) JP5751631B2 (ru)
KR (1) KR101683033B1 (ru)
CN (2) CN105601742A (ru)
AU (1) AU2009308763B2 (ru)
BR (1) BRPI0921696A2 (ru)
CA (1) CA2742014A1 (ru)
CL (1) CL2011000975A1 (ru)
CO (1) CO6362052A2 (ru)
CY (1) CY1118797T1 (ru)
DK (1) DK2350304T3 (ru)
EA (2) EA022832B1 (ru)
EC (1) ECSP11011072A (ru)
ES (1) ES2618567T3 (ru)
HK (1) HK1166105A1 (ru)
HR (1) HRP20170415T1 (ru)
HU (1) HUE031756T2 (ru)
IL (1) IL212545A (ru)
LT (1) LT2350304T (ru)
MX (1) MX2011004635A (ru)
MY (1) MY183144A (ru)
NI (1) NI201100085A (ru)
NZ (2) NZ603824A (ru)
PE (1) PE20110808A1 (ru)
PL (1) PL2350304T3 (ru)
PT (1) PT2350304T (ru)
RS (1) RS55861B1 (ru)
SI (1) SI2350304T1 (ru)
SM (1) SMT201700127B (ru)
SV (1) SV2011003891A (ru)
UA (1) UA109397C2 (ru)
WO (1) WO2010051470A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130090457A1 (en) * 2008-10-31 2013-04-11 Janssen Biotech, Inc. Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases
US8460659B2 (en) 2008-10-31 2013-06-11 Janssen Biotech, Inc. Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
AU2009308763B2 (en) 2008-10-31 2017-03-09 Janssen Biotech, Inc. Toll-like receptor 3 antagonists
EA021512B1 (ru) * 2009-04-29 2015-07-30 Янссен Байотек Инк. Антагонисты толл-подобного рецептора 3
WO2011004028A2 (en) 2009-07-10 2011-01-13 Innate Pharma Tlr3 binding agents
AU2012206614A1 (en) 2011-01-12 2013-08-01 Innate Pharma TLR3 binding agents
CA2855955A1 (en) * 2011-09-12 2013-03-21 Janssen Biotech, Inc. Toll-like receptor 3 antagonists
MX361773B (es) 2012-05-31 2018-12-17 Innate Pharma Agentes de ligación a tlr3.
EP3560960A1 (en) * 2013-04-22 2019-10-30 The University of Tokyo Preventive or therapeutic agent for inflammatory disease
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
WO2015016282A1 (ja) * 2013-07-30 2015-02-05 国立大学法人東京大学 放射線誘導性消化管症候群の予防又は治療用医薬組成物
GB201522394D0 (en) * 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
BR112018014810A2 (pt) 2016-01-22 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-fator xi de coagulação
AR108717A1 (es) 2016-06-14 2018-09-19 Merck Sharp & Dohme Anticuerpos antifactor de la coagulación xi
US10429214B2 (en) * 2017-03-07 2019-10-01 Newtonoid Technologies, L.L.C. Modular elongated wall-mounted sensor system and method
CN109136231B (zh) * 2018-09-14 2019-08-30 苏州大学 一种翘嘴鳜tlr3基因及其应用
WO2023235771A2 (en) * 2022-05-31 2023-12-07 The University Of Chicago Chemical screen of modulators for vaccine adjuvants

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
CA2461315A1 (en) * 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Toll-like receptor 3 signaling agonists and antagonists
JP2004016021A (ja) * 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
BRPI0411514A (pt) 2003-06-20 2006-08-01 Coley Pharm Gmbh antagonistas de receptor toll-like de molécula pequena
CA2483732A1 (en) 2004-09-29 2006-03-29 Ronan Le Goffic Toll-like receptor 3, its signalling associated molecule trif and their use thereof
TWI487535B (zh) * 2004-11-30 2015-06-11 Centocor Inc 類鐸受體3(toll like receptor3)拮抗劑,方法及用途
UA97229C2 (ru) * 2004-11-30 2012-01-25 Центокор, Инк. Изолированное моноклональное антитело, которое специфически связывается с toll-подобным рецептором 3 (tlr3)
ES2435775T3 (es) * 2005-10-27 2013-12-23 Janssen Biotech, Inc. Moduladores de receptor tipo Toll 3, procedimientos y usos
US20100183638A1 (en) * 2007-03-05 2010-07-22 Gowen Brian B Restrictive agonist of toll-like receptor 3 (tlr3)
EP2155889A4 (en) 2007-05-25 2010-06-16 Centocor Ortho Biotech Inc TOLL RECEPTOR 3 MODULATORS AND USES THEREOF
US8273541B2 (en) 2008-09-17 2012-09-25 Innate Pharma Compositions and methods for detecting TLR3
WO2010040054A2 (en) 2008-10-02 2010-04-08 Centocor Ortho Biotech Inc. Methods for suppressing toll-like receptor activity
AU2009308763B2 (en) 2008-10-31 2017-03-09 Janssen Biotech, Inc. Toll-like receptor 3 antagonists
US20100188778A1 (en) * 2009-01-29 2010-07-29 Castagna Joseph T Disk Drive Assembly Having Flexible Support for Flexible Printed Circuit Board
EA021512B1 (ru) 2009-04-29 2015-07-30 Янссен Байотек Инк. Антагонисты толл-подобного рецептора 3
WO2011004028A2 (en) * 2009-07-10 2011-01-13 Innate Pharma Tlr3 binding agents

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