EA200701192A1 - Антагонисты toll-подобного рецептора 3, способы их получения и применение - Google Patents

Антагонисты toll-подобного рецептора 3, способы их получения и применение

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Publication number
EA200701192A1
EA200701192A1 EA200701192A EA200701192A EA200701192A1 EA 200701192 A1 EA200701192 A1 EA 200701192A1 EA 200701192 A EA200701192 A EA 200701192A EA 200701192 A EA200701192 A EA 200701192A EA 200701192 A1 EA200701192 A1 EA 200701192A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
toll
receptor
methods
reception
Prior art date
Application number
EA200701192A
Other languages
English (en)
Inventor
Джилл Картон
Марк Каннингхэм
Анук Дас
Карен Даффи
Дэвид М. Найт
Роберта Лэмб
Моухамадоу Л. Мбоу
Гопалан Рагхунатхан
Лани Сан Матео
Роберт Т. Сариски
Николь Стоуэлл
Рэймонд Свит
Шаньжун Чжао
Шичжун Чэнь
Джилл Джайлс-Комар
Кристен Пича
Ведрана Стоянович-Сусулич
Тереза Дж. Голетц
Original Assignee
Сентокор, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентокор, Инк. filed Critical Сентокор, Инк.
Publication of EA200701192A1 publication Critical patent/EA200701192A1/ru

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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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Abstract

Раскрываются антагонисты Toll-подобного рецептора 3 (TLR3), полинуклеотиды, кодирующие антагонисты TLR3 или их фрагменты, а также способы получения и применения вышеуказанных соединений.
EA200701192A 2004-11-30 2005-11-30 Антагонисты toll-подобного рецептора 3, способы их получения и применение EA200701192A1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
US63639904P 2004-12-15 2004-12-15
US64187705P 2005-01-06 2005-01-06
US71319505P 2005-08-31 2005-08-31
US72761005P 2005-10-18 2005-10-18
PCT/US2005/043373 WO2006060513A2 (en) 2004-11-30 2005-11-30 Toll like receptor 3 antagonists, methods and uses

Publications (1)

Publication Number Publication Date
EA200701192A1 true EA200701192A1 (ru) 2009-12-30

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Application Number Title Priority Date Filing Date
EA200701192A EA200701192A1 (ru) 2004-11-30 2005-11-30 Антагонисты toll-подобного рецептора 3, способы их получения и применение

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Country Link
US (1) US8153583B2 (ru)
EP (2) EP1824514B1 (ru)
JP (2) JP5039560B2 (ru)
KR (1) KR101317264B1 (ru)
AR (1) AR051836A1 (ru)
AU (1) AU2005311894A1 (ru)
BR (1) BRPI0518664A2 (ru)
CA (1) CA2589636C (ru)
EA (1) EA200701192A1 (ru)
HK (2) HK1111360A1 (ru)
IL (1) IL183541A (ru)
MX (1) MX2007006442A (ru)
NO (1) NO20073293L (ru)
NZ (1) NZ555475A (ru)
TW (1) TWI487535B (ru)
WO (1) WO2006060513A2 (ru)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
JP5199878B2 (ja) * 2005-10-27 2013-05-15 セントカー・インコーポレーテツド Toll様受容体3モジュレーター、方法および用途
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
JP2010527633A (ja) * 2007-05-25 2010-08-19 セントコア・オーソ・バイオテツク・インコーポレーテツド Toll様受容体3モジュレーター及びその使用
CA2708251C (en) 2007-12-07 2016-04-12 Zymogenetics, Inc. Humanized antibody molecules specific for il-31
EP2238155A4 (en) * 2007-12-26 2011-07-06 Centocor Ortho Biotech Inc CYNOMOLGUS TYPE TOLL 3 RECEIVER
EP2294085A1 (en) * 2008-06-09 2011-03-16 Novartis AG Antibodies against neisserial factor h binding protein
EP2138513B1 (en) * 2008-06-27 2011-02-09 Theranor SPRL Pharmaceutical compositions of antibodies for diseases caused by viruses
WO2010040054A2 (en) * 2008-10-02 2010-04-08 Centocor Ortho Biotech Inc. Methods for suppressing toll-like receptor activity
SI2350304T1 (sl) * 2008-10-31 2017-04-26 Janssen Biotech, Inc. Antagonisti toll-u podobnega receptorja
US8460659B2 (en) 2008-10-31 2013-06-11 Janssen Biotech, Inc. Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135908A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
CN102482699A (zh) * 2009-04-29 2012-05-30 詹森生物科技公司 Toll样受体3拮抗剂
EP2451844B1 (en) 2009-07-10 2015-04-22 Innate Pharma Tlr3 binding agents
MX2012003770A (es) 2009-09-30 2012-08-03 Harvard College Metodos para la modulacion de autofagia a traves de la modulacion de productos de genes que aumentan la autofagia.
CA2824313A1 (en) 2011-01-12 2012-07-19 Innate Pharma Tlr3 binding agents
PT2748201T (pt) * 2011-08-23 2018-02-08 Roche Glycart Ag Moléculas de ligação ao antigénio biespecíficas que ativam as células t
WO2013026837A1 (en) * 2011-08-23 2013-02-28 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
CA2855955A1 (en) * 2011-09-12 2013-03-21 Janssen Biotech, Inc. Toll-like receptor 3 antagonists
EP2855527B1 (en) 2012-05-31 2018-08-01 Innate Pharma Tlr3 binding agents
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
KR101833602B1 (ko) * 2013-02-26 2018-02-28 로슈 글리카트 아게 이중특이적 t 세포 활성화 항원 결합 분자
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
EP3221359B1 (en) 2014-11-17 2020-05-27 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using cd3xcd20 bispecific antibody
EP3277725B1 (en) 2015-03-30 2020-11-25 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to fc gamma receptors
CN107849137B (zh) 2015-10-02 2021-11-26 豪夫迈·罗氏有限公司 双特异性抗ceaxcd3 t细胞活化性抗原结合分子
AU2016368469B2 (en) 2015-12-09 2023-11-02 F. Hoffmann-La Roche Ag Type II anti-CD20 antibody for reducing formation of anti-drug antibodies
KR20180097615A (ko) 2016-01-08 2018-08-31 에프. 호프만-라 로슈 아게 Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US20230009902A1 (en) 2018-06-20 2023-01-12 Progenity, Inc. Treatment of a disease or condition in a tissue orginating from the endoderm
WO2020047389A1 (en) 2018-08-31 2020-03-05 Regeneron Pharmaceuticals, Inc. Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
CN1800214A (zh) 1997-05-07 2006-07-12 先灵公司 人Toll样受体蛋白、相关试剂和方法
WO2000053224A2 (en) 1999-03-09 2000-09-14 Max-Delbrück-Centrum für Molekulare Medizin Use of inhibitors of endotoxin for the treatment of heart failure and of cachexia
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
US7709451B2 (en) * 2001-09-07 2010-05-04 Trustees Of Boston University Method and composition for treating immune complex associated disorders
EP1451581A4 (en) 2001-10-05 2006-01-11 Coley Pharm Gmbh AGONISTS AND ANTAGONISTS OF THE SIGNALING OF THE GREAT-SIMILAR RECEPTOR 3
AU2003236290A1 (en) 2002-04-08 2003-10-20 Takeda Chemical Industries, Ltd. Severe sepsis preventive therapeutic agent
JP2004016021A (ja) * 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
BRPI0411514A (pt) * 2003-06-20 2006-08-01 Coley Pharm Gmbh antagonistas de receptor toll-like de molécula pequena

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