EA200400809A1 - Способ получения эсциталопрама - Google Patents

Способ получения эсциталопрама

Info

Publication number
EA200400809A1
EA200400809A1 EA200400809A EA200400809A EA200400809A1 EA 200400809 A1 EA200400809 A1 EA 200400809A1 EA 200400809 A EA200400809 A EA 200400809A EA 200400809 A EA200400809 A EA 200400809A EA 200400809 A1 EA200400809 A1 EA 200400809A1
Authority
EA
Eurasian Patent Office
Prior art keywords
escitaloprama
obtaining
cyanidation
formulas
iii
Prior art date
Application number
EA200400809A
Other languages
English (en)
Inventor
Халех Ахмадиан
Ханс Петерсен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200400809A1 publication Critical patent/EA200400809A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Amplifiers (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

Изобретение относится к способу получения эсциталопрама цианированием оптически активных промежуточных соединений формул (III) и (II) и к получению таких промежуточных соединений оптическим разделением.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400809A 2001-12-14 2002-12-09 Способ получения эсциталопрама EA200400809A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101881 2001-12-14
PCT/DK2002/000837 WO2003051861A1 (en) 2001-12-14 2002-12-09 Method for the preparation of escitalopram

Publications (1)

Publication Number Publication Date
EA200400809A1 true EA200400809A1 (ru) 2004-12-30

Family

ID=34072369

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400809A EA200400809A1 (ru) 2001-12-14 2002-12-09 Способ получения эсциталопрама

Country Status (22)

Country Link
US (1) US20050154051A1 (ru)
EP (1) EP1458701A1 (ru)
JP (1) JP2005513069A (ru)
KR (1) KR20040073463A (ru)
CN (1) CN1602305A (ru)
AR (1) AR037795A1 (ru)
AU (1) AU2002351726A1 (ru)
BR (1) BR0214327A (ru)
CA (1) CA2470225A1 (ru)
CO (1) CO5590910A2 (ru)
EA (1) EA200400809A1 (ru)
HR (1) HRP20040390A2 (ru)
HU (1) HUP0402252A3 (ru)
IL (1) IL161714A0 (ru)
IS (1) IS7239A (ru)
MX (1) MXPA04005766A (ru)
NO (1) NO20042667L (ru)
PL (1) PL368986A1 (ru)
RS (1) RS50704A (ru)
TW (1) TW200409625A (ru)
WO (1) WO2003051861A1 (ru)
ZA (1) ZA200403432B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
ES2228274B1 (es) * 2003-09-24 2006-06-01 Astur Pharma, S.A. Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
WO2006025071A1 (en) * 2004-09-02 2006-03-09 Natco Pharma Limited A process for the preparation of escitalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP1987016A1 (en) * 2005-07-27 2008-11-05 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
EP1954257A4 (en) 2005-10-14 2009-05-20 Lundbeck & Co As H METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
NZ570884A (en) * 2007-09-11 2010-03-26 Lundbeck & Co As H Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AU738359B2 (en) * 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
DK1123284T3 (da) * 1998-10-20 2003-04-28 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
ATE286037T1 (de) * 2001-08-02 2005-01-15 Infosint Sa Verfahren zur herstellung von 5-substituierten isobenzofuranen

Also Published As

Publication number Publication date
EP1458701A1 (en) 2004-09-22
TW200409625A (en) 2004-06-16
IL161714A0 (en) 2004-09-27
BR0214327A (pt) 2004-11-03
HRP20040390A2 (en) 2004-08-31
MXPA04005766A (es) 2004-09-10
KR20040073463A (ko) 2004-08-19
IS7239A (is) 2004-04-29
HUP0402252A2 (hu) 2005-02-28
WO2003051861A1 (en) 2003-06-26
CO5590910A2 (es) 2005-12-30
PL368986A1 (en) 2005-04-04
CA2470225A1 (en) 2003-06-26
CN1602305A (zh) 2005-03-30
AU2002351726A1 (en) 2003-06-30
RS50704A (en) 2007-02-05
AR037795A1 (es) 2004-12-01
ZA200403432B (en) 2005-05-06
US20050154051A1 (en) 2005-07-14
HUP0402252A3 (en) 2007-05-29
JP2005513069A (ja) 2005-05-12
NO20042667L (no) 2004-06-24

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