DOP2013000192A - Compuestos y composiciones como inhibidores de la trk - Google Patents
Compuestos y composiciones como inhibidores de la trkInfo
- Publication number
- DOP2013000192A DOP2013000192A DO2013000192A DO2013000192A DOP2013000192A DO P2013000192 A DOP2013000192 A DO P2013000192A DO 2013000192 A DO2013000192 A DO 2013000192A DO 2013000192 A DO2013000192 A DO 2013000192A DO P2013000192 A DOP2013000192 A DO P2013000192A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- trk
- compositions
- inhibitors
- abnormal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona compuestos, composiciones farmaceuticas que comprenden tales compuestos y procedimientos para Ia fabricación de medicamentos contentivos de tales compuestos para su uso en el tratamiento o prevención de enfermedades o trastornos asociados con la actividad anormal o desregulada de Ia quinasa TRK.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161446572P | 2011-02-25 | 2011-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2013000192A true DOP2013000192A (es) | 2014-01-31 |
Family
ID=45815979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2013000192A DOP2013000192A (es) | 2011-02-25 | 2013-08-23 | Compuestos y composiciones como inhibidores de la trk |
Country Status (27)
Country | Link |
---|---|
US (1) | US9102671B2 (es) |
EP (1) | EP2678338B1 (es) |
JP (1) | JP5959541B2 (es) |
KR (1) | KR20140014184A (es) |
CN (1) | CN103492384B (es) |
AP (1) | AP2013007103A0 (es) |
AU (1) | AU2012220572A1 (es) |
BR (1) | BR112013021638A2 (es) |
CA (1) | CA2828219A1 (es) |
CL (1) | CL2013002430A1 (es) |
CO (1) | CO6751270A2 (es) |
CR (1) | CR20130410A (es) |
CU (1) | CU20130115A7 (es) |
DO (1) | DOP2013000192A (es) |
EA (1) | EA201391230A1 (es) |
ES (1) | ES2551592T3 (es) |
GE (1) | GEP20156285B (es) |
GT (1) | GT201300209A (es) |
IL (1) | IL227987A0 (es) |
MA (1) | MA34969B1 (es) |
MX (1) | MX2013009767A (es) |
NI (1) | NI201300073A (es) |
PE (1) | PE20140378A1 (es) |
SG (1) | SG192795A1 (es) |
TN (1) | TN2013000348A1 (es) |
WO (1) | WO2012116217A1 (es) |
ZA (1) | ZA201306221B (es) |
Families Citing this family (53)
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ES2464461T3 (es) | 2008-09-22 | 2014-06-02 | Array Biopharma, Inc. | Compuestos de imidazo[1,2B]piridazina sustituidos como inhibidores de la TRK cinasa |
KR101853026B1 (ko) | 2008-10-22 | 2018-04-27 | 어레이 바이오파마 인크. | TRK 키나아제 억제제로서 치환된 피라졸로[1,5a] 피리미딘 화합물 |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
MY191934A (en) | 2010-05-20 | 2022-07-19 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
BR112014014276A2 (pt) | 2011-12-12 | 2017-06-13 | Dr Reddys Laboratories Ltd | composto, composição farmacêutica, método para inibir uma cinase receptora, e, métodos para tratar condições, doenças e/ou distúrbios, e dor |
EP3027655B1 (en) | 2013-07-30 | 2019-08-21 | Blueprint Medicines Corporation | Ntrk2 fusions |
BR112016015057A2 (pt) * | 2013-12-26 | 2017-08-08 | Ignyta Inc | Compostos e composições farmacêuticas e respectivos usos |
AU2015214185B2 (en) * | 2014-02-05 | 2016-08-04 | VM Oncology LLC | Compositions of compounds and uses thereof |
CN105524058B (zh) * | 2014-10-21 | 2018-03-27 | 广州艾格生物科技有限公司 | 吡唑并[1,5‑a]吡啶类化合物及其应用 |
FI3699181T3 (fi) | 2014-11-16 | 2023-03-28 | Array Biopharma Inc | Kiteinen muoto (s)-n-(5-((r)-2-(2,5-diluorifenyyli)-pyrrolidin-1-yyli)-pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidivetyysulfaatista |
CN104529815B (zh) * | 2014-12-04 | 2016-08-24 | 宁波欧迅化学新材料技术有限公司 | 合成2,4-二硝基苯氧胺的方法 |
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KR20180041135A (ko) | 2015-07-16 | 2018-04-23 | 어레이 바이오파마 인크. | Ret 키나아제 억제제로서 치환된 피라졸로[1,5-a]피리딘 화합물 |
CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
CA3019671C (en) | 2016-04-04 | 2024-02-20 | Loxo Oncology, Inc. | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
FI3439663T3 (fi) | 2016-04-04 | 2024-08-28 | Loxo Oncology Inc | Menetelmiä lasten syöpien hoitamiseksi |
RS61463B1 (sr) | 2016-05-18 | 2021-03-31 | Loxo Oncology Inc | Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il) -3-hidroksipirolidin-1-karboksamida |
KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
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TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
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TW202410896A (zh) | 2017-10-10 | 2024-03-16 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
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EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
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CN110643672A (zh) * | 2019-10-15 | 2020-01-03 | 西安交通大学 | 高表达TrkB作为新型靶点在抑制胰腺癌转移方面的医药用途 |
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CN112779518B (zh) * | 2020-12-17 | 2022-07-22 | 东北师范大学 | 一种高发光强度的薄膜、制备方法及其用途 |
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AU2009246687B2 (en) * | 2008-05-13 | 2012-08-09 | Irm Llc | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
JP5559174B2 (ja) * | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
KR101853026B1 (ko) * | 2008-10-22 | 2018-04-27 | 어레이 바이오파마 인크. | TRK 키나아제 억제제로서 치환된 피라졸로[1,5a] 피리미딘 화합물 |
TW201022233A (en) * | 2008-11-04 | 2010-06-16 | Organon Nv | (Pyrrolidin-2-yl)phenyl derivatives |
US8927545B2 (en) * | 2009-03-30 | 2015-01-06 | Duke University | Inhibiting Eph B-3 kinase |
AR077468A1 (es) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
-
2012
- 2012-02-23 EP EP12708450.7A patent/EP2678338B1/en active Active
- 2012-02-23 PE PE2013001975A patent/PE20140378A1/es not_active Application Discontinuation
- 2012-02-23 BR BR112013021638A patent/BR112013021638A2/pt not_active IP Right Cessation
- 2012-02-23 CN CN201280019867.0A patent/CN103492384B/zh not_active Expired - Fee Related
- 2012-02-23 EA EA201391230A patent/EA201391230A1/ru unknown
- 2012-02-23 KR KR1020137025068A patent/KR20140014184A/ko not_active Application Discontinuation
- 2012-02-23 MA MA36253A patent/MA34969B1/fr unknown
- 2012-02-23 ES ES12708450.7T patent/ES2551592T3/es active Active
- 2012-02-23 JP JP2013555571A patent/JP5959541B2/ja not_active Expired - Fee Related
- 2012-02-23 AP AP2013007103A patent/AP2013007103A0/xx unknown
- 2012-02-23 US US14/000,578 patent/US9102671B2/en active Active
- 2012-02-23 SG SG2013062179A patent/SG192795A1/en unknown
- 2012-02-23 GE GEAP201213241A patent/GEP20156285B/en unknown
- 2012-02-23 WO PCT/US2012/026377 patent/WO2012116217A1/en active Application Filing
- 2012-02-23 MX MX2013009767A patent/MX2013009767A/es not_active Application Discontinuation
- 2012-02-23 CA CA2828219A patent/CA2828219A1/en not_active Abandoned
- 2012-02-23 AU AU2012220572A patent/AU2012220572A1/en not_active Abandoned
-
2013
- 2013-08-15 IL IL227987A patent/IL227987A0/en unknown
- 2013-08-19 ZA ZA2013/06221A patent/ZA201306221B/en unknown
- 2013-08-19 TN TNP2013000348A patent/TN2013000348A1/fr unknown
- 2013-08-22 CL CL2013002430A patent/CL2013002430A1/es unknown
- 2013-08-22 CO CO13199508A patent/CO6751270A2/es unknown
- 2013-08-23 GT GT201300209A patent/GT201300209A/es unknown
- 2013-08-23 DO DO2013000192A patent/DOP2013000192A/es unknown
- 2013-08-23 NI NI201300073A patent/NI201300073A/es unknown
- 2013-08-23 CU CU2013000115A patent/CU20130115A7/es unknown
- 2013-08-26 CR CR20130410A patent/CR20130410A/es unknown
Also Published As
Publication number | Publication date |
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CR20130410A (es) | 2013-10-17 |
CO6751270A2 (es) | 2013-09-16 |
MX2013009767A (es) | 2013-10-01 |
KR20140014184A (ko) | 2014-02-05 |
AU2012220572A1 (en) | 2013-08-29 |
ES2551592T3 (es) | 2015-11-20 |
AP2013007103A0 (en) | 2013-09-30 |
GEP20156285B (en) | 2015-05-11 |
US9102671B2 (en) | 2015-08-11 |
CU20130115A7 (es) | 2013-12-27 |
IL227987A0 (en) | 2013-09-30 |
CL2013002430A1 (es) | 2013-11-29 |
ZA201306221B (en) | 2014-04-30 |
CA2828219A1 (en) | 2012-08-30 |
EP2678338A1 (en) | 2014-01-01 |
MA34969B1 (fr) | 2014-03-01 |
WO2012116217A1 (en) | 2012-08-30 |
PE20140378A1 (es) | 2014-03-28 |
TN2013000348A1 (en) | 2015-01-20 |
GT201300209A (es) | 2015-06-02 |
JP2014506599A (ja) | 2014-03-17 |
CN103492384A (zh) | 2014-01-01 |
JP5959541B2 (ja) | 2016-08-02 |
US20130331397A1 (en) | 2013-12-12 |
EA201391230A1 (ru) | 2014-01-30 |
SG192795A1 (en) | 2013-09-30 |
NI201300073A (es) | 2013-12-17 |
BR112013021638A2 (pt) | 2016-08-02 |
EP2678338B1 (en) | 2015-09-09 |
CN103492384B (zh) | 2016-05-11 |
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