DOP2012000153A - Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedades inmunes - Google Patents

Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedades inmunes

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Publication number
DOP2012000153A
DOP2012000153A DO2012000153A DO2012000153A DOP2012000153A DO P2012000153 A DOP2012000153 A DO P2012000153A DO 2012000153 A DO2012000153 A DO 2012000153A DO 2012000153 A DO2012000153 A DO 2012000153A DO P2012000153 A DOP2012000153 A DO P2012000153A
Authority
DO
Dominican Republic
Prior art keywords
cancer
bcl
treatment
selectivity
cells
Prior art date
Application number
DO2012000153A
Other languages
English (en)
Inventor
Steven W Elmore
Andrew J Souers
Milan Bruncko
Xiaohong Song
Xilu Wang
Le Wang
Cheol-Min Park
Zhi-Fu Tao
Hong Ding
Lisa Hasvold
Laura Hexamer
William J Mcclellan
Chang H Park
Andrew M Petros
Gerard M Sullivan
Gary T Wang
Michael D Wendt
Robert A Mantei
Todd M Hansen
George A Doherty
Aaron Kunzer
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42481688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2012000153(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of DOP2012000153A publication Critical patent/DOP2012000153A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Compuestos de Fórmula I derivados de sulfonamida, por ejemplo, N-({5-cloro-6-[(4,4-difluorociclohexil)metoxi]piridin-3-il}sulfonil)-4-(4-{[2-(4-clorofenil)-4,4-dimetilciclohex-1-en-1-il]metil}piperazin-1-il)-2-(1H-indazol-4-iloxi)benzamida, que inhiben la actividad de las proteínas anti-apoptóticas Bcl- 2 o Bcl-XL y composiciones que contienen dichos compuestos, los cuales sirven para preparer un medicamento útil en el tratamiento de enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2, por ejemplo, cáncer de vejiga, cáncer de cerebro, cáncer de mamas, cáncer de médula ósea, cáncer cervical, leucemia linfocítica crónica, cáncer colorrectal, cancer de esófago, cáncer hepatocelular, leucemia linfoblástica, linfoma folicular, una malignidad linfoide originada en células T o células B, melanoma, leucemia mielógena, mieloma, cáncer oral, cáncer de ovarios, cáncer de pulmón de células no pequeñas, cáncer de próstata, cáncer de pulmón de células pequeñas o cáncer de bazo, entre otras.
DO2012000153A 2009-12-04 2012-06-01 Derivados de sulfonamida como agentes inductores de apoptosis con selectividad por bcl-2 para el tratamiento de cancer y enfermedades inmunes DOP2012000153A (es)

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