DK2283117T3 - Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller - Google Patents
Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamcellerInfo
- Publication number
- DK2283117T3 DK2283117T3 DK08816858.8T DK08816858T DK2283117T3 DK 2283117 T3 DK2283117 T3 DK 2283117T3 DK 08816858 T DK08816858 T DK 08816858T DK 2283117 T3 DK2283117 T3 DK 2283117T3
- Authority
- DK
- Denmark
- Prior art keywords
- cleaning
- procedure
- embryonic stem
- human embryonic
- pancreatic endoderm
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2008/061053 WO2009131568A1 (en) | 2008-04-21 | 2008-04-21 | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2283117T3 true DK2283117T3 (da) | 2014-01-20 |
Family
ID=41217089
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08816858.8T DK2283117T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
| DK13188913.1T DK2727998T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåder til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13188913.1T DK2727998T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåder til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2283117B1 (da) |
| AU (1) | AU2008355123B2 (da) |
| DK (2) | DK2283117T3 (da) |
| HK (1) | HK1154404A1 (da) |
| WO (1) | WO2009131568A1 (da) |
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| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| CN101484575B (zh) | 2005-06-08 | 2013-10-02 | 森托科尔公司 | 用于眼变性的细胞疗法 |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| BRPI0814894A2 (pt) | 2007-07-31 | 2014-10-21 | Lifescan Inc | Diferenciação de células-tronco embrionárias de ser humano. |
| WO2009070592A2 (en) | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| US10066203B2 (en) | 2008-02-21 | 2018-09-04 | Janssen Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| US9234178B2 (en) | 2008-10-31 | 2016-01-12 | Janssen Biotech, Inc. | Differentiation of human pluripotent stem cells |
| CN102333862B (zh) | 2008-10-31 | 2018-04-27 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌谱系的分化 |
| JP2012509085A (ja) | 2008-11-20 | 2012-04-19 | ヤンセン バイオテツク，インコーポレーテツド | マイクロキャリア上での多能性幹細胞の培養 |
| CN102257132B (zh) | 2008-11-20 | 2014-09-03 | 森托科尔奥索生物科技公司 | 用于在平面基底上进行细胞附着和培养的方法和组合物 |
| KR101785626B1 (ko) | 2009-07-20 | 2017-10-16 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| GB2484873B (en) | 2009-07-20 | 2014-04-30 | Janssen Biotech Inc | Differentiation of pancreatic endoderm cells. |
| AR077766A1 (es) | 2009-07-20 | 2011-09-21 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas |
| ES2365343B1 (es) * | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| RU2610176C2 (ru) | 2009-12-23 | 2017-02-08 | Янссен Байотек, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| JP5882226B2 (ja) | 2009-12-23 | 2016-03-09 | ヤンセン バイオテツク，インコーポレーテツド | ヒト胚性幹細胞の分化 |
| US9969981B2 (en) * | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| ES2728900T3 (es) | 2010-05-12 | 2019-10-29 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas |
| SG187944A1 (en) | 2010-08-31 | 2013-04-30 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| RU2599420C2 (ru) | 2010-08-31 | 2016-10-10 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
| CN103221536B (zh) | 2010-08-31 | 2016-08-31 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| WO2012037456A1 (en) * | 2010-09-17 | 2012-03-22 | President And Fellows Of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
| WO2013095953A1 (en) | 2011-12-22 | 2013-06-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| EP2823037A4 (en) | 2012-03-07 | 2015-09-16 | Janssen Biotech Inc | DEFINED MEDIA FOR THE EXPANSION AND CARE OF PLURIPOTENTAL STEM CELLS |
| JP6469003B2 (ja) | 2012-06-08 | 2019-02-13 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞へのヒト胚性幹細胞の分化 |
| EP2893000B1 (en) | 2012-09-03 | 2019-04-10 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| CN105008518B (zh) | 2012-12-31 | 2020-08-07 | 詹森生物科技公司 | 在空气-液体界面处培养人胚胎干细胞以用于分化成胰腺内分泌细胞 |
| JP6529440B2 (ja) | 2012-12-31 | 2019-06-12 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞への分化のためのヒト多能性細胞の懸濁及びクラスタリング |
| KR101942769B1 (ko) | 2012-12-31 | 2019-01-28 | 얀센 바이오테크 인코포레이티드 | Hb9 조절제를 사용하는 인간 배아 줄기세포의 췌장 내분비 세포로의 분화 |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| US11085067B2 (en) | 2013-06-10 | 2021-08-10 | President And Fellows Of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| RU2016100219A (ru) | 2013-06-11 | 2017-07-17 | Президент Энд Феллоус Оф Гарвард Колледж | КЛЕТКИ SC-β И КОМПОЗИЦИИ, И СПОСОБЫ ДЛЯ ИХ СОЗДАНИЯ |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| US10253298B2 (en) | 2014-12-18 | 2019-04-09 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and methods of use thereof |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| EP3286300B1 (en) | 2015-04-24 | 2020-10-21 | University of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| JP6909230B2 (ja) * | 2015-11-30 | 2021-07-28 | カディマステム リミテッド | 膵臓内分泌細胞の分化および精製のための方法 |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| US20210147807A1 (en) * | 2017-06-14 | 2021-05-20 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| IL312134A (en) | 2017-11-15 | 2024-06-01 | Vertex Pharma | Preparations for the production of islet cells and methods of use |
| CA3108275A1 (en) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| JP2022535239A (ja) | 2019-05-31 | 2022-08-05 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 生体適合性メンブレン複合体 |
| AU2020283150B2 (en) | 2019-05-31 | 2023-08-17 | Viacyte, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| WO2020243663A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| CA1335181C (en) | 1988-10-11 | 1995-04-11 | R. Alan Hardwick | System for selective cell separation from cell concentrate |
| DE68919715T2 (de) | 1988-12-28 | 1995-04-06 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| US5171846A (en) | 1990-05-21 | 1992-12-15 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use |
| US5272257A (en) | 1990-05-21 | 1993-12-21 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use |
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| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
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| US5248772A (en) | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| JPH10507997A (ja) | 1993-06-11 | 1998-08-04 | クールター コーポレイション | Ｔ細胞の活性化および増殖を誘導するための抗ｃｄ３抗体−アミノデキストラン結合体 |
| US5989833A (en) | 1994-09-20 | 1999-11-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for detection of molecules with affinity for MPL polypeptides |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| EP0885308A4 (en) | 1996-02-28 | 2002-02-27 | Univ Vanderbilt | CONNECTIONS AND METHODS FOR THE PRODUCTION OF EMBRYONIC STEM CELLS |
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| US5945293A (en) | 1997-10-09 | 1999-08-31 | Coulter International Corp. | Protein-colloidal metal-aminodextran coated particle and methods of preparation and use |
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| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| EP1670900A4 (en) * | 2003-08-27 | 2008-06-11 | Stemcells California Inc | ENHANCED PANCREATIC STEM CELL AND PRECURSOR CELL POPULATIONS AND METHOD OF IDENTIFYING, INSULATING AND ENRICHING SUCH POPULATIONS |
| AU2004309421B2 (en) | 2003-12-23 | 2011-04-21 | Viacyte, Inc. | Definitive endoderm |
| ES2711278T3 (es) * | 2005-12-29 | 2019-04-30 | Celularity Inc | Poblaciones de células madre placentarias |
| US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB2506936A (en) | 2012-10-15 | 2014-04-16 | Innovia Films Ltd | Birefringence authentication apparatus and method |
-
2008
- 2008-04-21 DK DK08816858.8T patent/DK2283117T3/da active
- 2008-04-21 EP EP08816858.8A patent/EP2283117B1/en active Active
- 2008-04-21 AU AU2008355123A patent/AU2008355123B2/en active Active
- 2008-04-21 EP EP13188913.1A patent/EP2727998B1/en active Active
- 2008-04-21 WO PCT/US2008/061053 patent/WO2009131568A1/en active Application Filing
- 2008-04-21 DK DK13188913.1T patent/DK2727998T3/da active
-
2011
- 2011-08-15 HK HK11108564.6A patent/HK1154404A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008355123A2 (en) | 2010-12-16 |
| WO2009131568A1 (en) | 2009-10-29 |
| AU2008355123B2 (en) | 2014-12-04 |
| DK2727998T3 (da) | 2019-08-26 |
| EP2283117A4 (en) | 2011-09-07 |
| EP2283117B1 (en) | 2013-10-23 |
| EP2283117A1 (en) | 2011-02-16 |
| EP2727998A2 (en) | 2014-05-07 |
| AU2008355123A1 (en) | 2009-10-29 |
| EP2727998B1 (en) | 2019-06-12 |
| EP2727998A3 (en) | 2014-08-13 |
| HK1154404A1 (en) | 2012-04-20 |
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