DK1165528T3 - Hidtil ukendte morpholinoderivater, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse - Google Patents

Hidtil ukendte morpholinoderivater, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse

Info

Publication number
DK1165528T3
DK1165528T3 DK00911009T DK00911009T DK1165528T3 DK 1165528 T3 DK1165528 T3 DK 1165528T3 DK 00911009 T DK00911009 T DK 00911009T DK 00911009 T DK00911009 T DK 00911009T DK 1165528 T3 DK1165528 T3 DK 1165528T3
Authority
DK
Denmark
Prior art keywords
preparing
methods
pharmaceutical preparations
preparations containing
morpholine derivatives
Prior art date
Application number
DK00911009T
Other languages
English (en)
Inventor
Patrick Gueule
Jean Philippe Ducoux
Xavier Emonds-Alt
Vincenzo Proietto
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1165528T3 publication Critical patent/DK1165528T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00911009T 1999-03-25 2000-03-21 Hidtil ukendte morpholinoderivater, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse DK1165528T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9903854A FR2791346B3 (fr) 1999-03-25 1999-03-25 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
EP00911009A EP1165528B1 (fr) 1999-03-25 2000-03-21 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/000695 WO2000058292A1 (fr) 1999-03-25 2000-03-21 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
DK1165528T3 true DK1165528T3 (da) 2005-01-10

Family

ID=9543720

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00911009T DK1165528T3 (da) 1999-03-25 2000-03-21 Hidtil ukendte morpholinoderivater, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse

Country Status (41)

Country Link
US (1) US6506750B1 (da)
EP (1) EP1165528B1 (da)
JP (1) JP3853155B2 (da)
KR (1) KR100696340B1 (da)
CN (1) CN100422160C (da)
AR (1) AR023139A1 (da)
AT (1) ATE275136T1 (da)
AU (1) AU756855B2 (da)
BG (1) BG64623B1 (da)
BR (1) BR0009281B1 (da)
CA (1) CA2366829C (da)
CO (1) CO5160340A1 (da)
CZ (1) CZ300911B6 (da)
DE (1) DE60013418T2 (da)
DK (1) DK1165528T3 (da)
EE (1) EE04525B1 (da)
ES (1) ES2226794T3 (da)
FR (1) FR2791346B3 (da)
HK (1) HK1042092B (da)
HR (1) HRP20010704B1 (da)
HU (1) HUP0201863A3 (da)
ID (1) ID29871A (da)
IL (2) IL145041A0 (da)
IS (1) IS2338B (da)
ME (2) ME00057B (da)
MX (1) MXPA01009643A (da)
NO (1) NO321576B1 (da)
NZ (1) NZ513674A (da)
PE (1) PE20001596A1 (da)
PL (1) PL205318B1 (da)
PT (1) PT1165528E (da)
RS (1) RS50085B (da)
RU (1) RU2222537C2 (da)
SI (1) SI1165528T1 (da)
SK (1) SK286977B6 (da)
TR (1) TR200102639T2 (da)
TW (1) TW534906B (da)
UA (1) UA73931C2 (da)
UY (1) UY26079A1 (da)
WO (1) WO2000058292A1 (da)
ZA (1) ZA200106981B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2234929T3 (es) * 2000-11-28 2005-07-01 Smithkline Beecham Plc Derivados de morfolina como antagonistas de los receptores de orexina.
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0228787D0 (en) * 2002-12-10 2003-01-15 Pfizer Ltd Morpholine dopamine agonists
JP2006511555A (ja) * 2002-12-13 2006-04-06 スミスクライン ビーチャム コーポレーション Ｃｃｒ５拮抗剤としての複素環式化合物
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
AR046769A1 (es) * 2003-12-22 2005-12-21 Schering Corp Composiciones farmaceuticas
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
CN103142569B (zh) * 2013-02-27 2016-01-20 南京医科大学 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ3134U1 (cs) * 1995-01-10 1995-03-17 Pavel Ing. Janda Rotor universálního radiálního ventilátoru
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5780466A (en) * 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
RU2135494C1 (ru) * 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
CA2312770A1 (en) * 1997-12-04 1999-06-10 Takahide Nishi Alicyclic acylated heterocyclic derivatives

Also Published As

Publication number Publication date
AU3301600A (en) 2000-10-16
SK286977B6 (sk) 2009-08-06
PL205318B1 (pl) 2010-04-30
AR023139A1 (es) 2002-09-04
CN100422160C (zh) 2008-10-01
FR2791346B3 (fr) 2001-04-27
WO2000058292A1 (fr) 2000-10-05
ATE275136T1 (de) 2004-09-15
YU68201A (sh) 2004-03-12
HK1042092B (zh) 2005-04-22
KR20010108381A (ko) 2001-12-07
ID29871A (id) 2001-10-18
TW534906B (en) 2003-06-01
CA2366829C (fr) 2007-05-15
JP3853155B2 (ja) 2006-12-06
EP1165528A1 (fr) 2002-01-02
ZA200106981B (en) 2002-10-24
TR200102639T2 (tr) 2002-02-21
FR2791346A1 (fr) 2000-09-29
RS50085B (sr) 2009-01-22
IS6063A (is) 2001-08-24
SI1165528T1 (en) 2005-02-28
AU756855B2 (en) 2003-01-23
NZ513674A (en) 2003-05-30
KR100696340B1 (ko) 2007-03-20
HUP0201863A3 (en) 2003-03-28
JP2002540195A (ja) 2002-11-26
HK1042092A1 (en) 2002-08-02
HRP20010704B1 (en) 2005-04-30
IL145041A0 (en) 2002-06-30
PE20001596A1 (es) 2001-04-01
CZ20013365A3 (cs) 2002-01-16
BR0009281B1 (pt) 2011-05-17
CA2366829A1 (fr) 2000-10-05
HUP0201863A2 (hu) 2002-12-28
IL145041A (en) 2010-11-30
EE200100499A (et) 2002-12-16
ES2226794T3 (es) 2005-04-01
RU2222537C2 (ru) 2004-01-27
NO20014632L (no) 2001-11-26
CO5160340A1 (es) 2002-05-30
MXPA01009643A (es) 2002-05-14
BG64623B1 (bg) 2005-09-30
NO20014632D0 (no) 2001-09-24
CZ300911B6 (cs) 2009-09-09
MEP12008A (en) 2010-06-10
UA73931C2 (en) 2005-10-17
US6506750B1 (en) 2003-01-14
PL351317A1 (en) 2003-04-07
BG105923A (en) 2002-05-31
DE60013418T2 (de) 2005-09-22
ME00057B (me) 2010-10-10
EE04525B1 (et) 2005-08-15
HRP20010704A2 (en) 2002-08-31
IS2338B (is) 2008-02-15
PT1165528E (pt) 2005-01-31
DE60013418D1 (de) 2004-10-07
CN1353698A (zh) 2002-06-12
UY26079A1 (es) 2000-10-31
BR0009281A (pt) 2002-01-22
EP1165528B1 (fr) 2004-09-01
SK13462001A3 (sk) 2002-05-09
NO321576B1 (no) 2006-06-06

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