DK0538477T3 - Hidtil ukendte cykliske aminophenyleddikesyrederivater, fremstilling deraf og immunreaktonskodulator, der indeholder disse som aktiv bestanddel - Google Patents

Hidtil ukendte cykliske aminophenyleddikesyrederivater, fremstilling deraf og immunreaktonskodulator, der indeholder disse som aktiv bestanddel

Info

Publication number: DK0538477T3
Authority: DK; Denmark
Prior art keywords: substituted; active ingredient; halogen; novel cyclic; aminophenylacetic acid
Prior art date: 1991-04-16

Application number

DK92908279T

Other languages

Danish (da)

English (en)

Inventor

Yasushi Kohno

Katsuya Awano

Takayoshi Ishizaki

Eisuke Kojima

Shinji Kudoh

Yasuhiko Sakoe

Koji Saito

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-16

Filing date

1992-04-15

Publication date

2002-11-11

1992-04-15 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2002-11-11 Application granted granted Critical

2002-11-11 Publication of DK0538477T3 publication Critical patent/DK0538477T3/da

Links

-1 cyclic aminophenylacetic acid derivatives Chemical class 0.000 title abstract 6
239000004480 active ingredient Substances 0.000 title abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
External Artificial Organs (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Quinoline Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

DK92908279T 1991-04-16 1992-04-15 Hidtil ukendte cykliske aminophenyleddikesyrederivater, fremstilling deraf og immunreaktonskodulator, der indeholder disse som aktiv bestanddel DK0538477T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP11100091		1991-04-16
JP11673092A JP3209568B2 (ja)	1991-04-16	1992-04-10	新規環状アミノフェニル酢酸誘導体、その製造法及びそれらを有効成分とする免疫応答の修飾剤
PCT/JP1992/000476 WO1992018482A1 (en)	1991-04-16	1992-04-15	Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient

Publications (1)

Publication Number	Publication Date
DK0538477T3 true DK0538477T3 (da)	2002-11-11

Family

ID=26450490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92908279T DK0538477T3 (da)	1991-04-16	1992-04-15	Hidtil ukendte cykliske aminophenyleddikesyrederivater, fremstilling deraf og immunreaktonskodulator, der indeholder disse som aktiv bestanddel

Country Status (19)

Country	Link
US (1)	US5359076A (zh)
EP (1)	EP0538477B1 (zh)
JP (1)	JP3209568B2 (zh)
KR (1)	KR960007085B1 (zh)
AT (1)	ATE226196T1 (zh)
AU (1)	AU647612B2 (zh)
BG (1)	BG61262B1 (zh)
CA (1)	CA2085347C (zh)
CZ (1)	CZ282165B6 (zh)
DE (1)	DE69232812T2 (zh)
DK (1)	DK0538477T3 (zh)
ES (1)	ES2184730T3 (zh)
FI (1)	FI101300B1 (zh)
HU (2)	HU222522B1 (zh)
NO (1)	NO179174C (zh)
RO (1)	RO114615B1 (zh)
SK (1)	SK282146B6 (zh)
TW (1)	TW203606B (zh)
WO (1)	WO1992018482A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL112567A (en) *	1994-02-10	2000-02-29	Wyeth John & Brother Ltd	Substituted quinolines their preparation and pharmaceutical compositions containing them
AU4583599A (en)	1998-06-25	2000-01-10	Sepracor, Inc.	Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
CN102958919A (zh) *	2010-07-02	2013-03-06	霍夫曼-拉罗奇有限公司	新的四氢喹啉衍生物
US8592594B2 (en) *	2010-07-02	2013-11-26	Hoffmann-La Roche Inc.	Tetrahydro-quinoline derivatives
JP6770005B2 (ja)	2016-02-10	2020-10-14	住友化学株式会社	１−メチルピロリジン−３−オールの製造方法
US20240116903A1 (en)	2020-12-25	2024-04-11	Toray Industries, Inc.	Tetrahydroquinoline derivative and medicinal use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2042352A1 (fr) *	1969-04-21	1971-02-12	Ciba Geigy Ag	Acides alpha-(1,2,3,4-tetrahydro-6-quinolyl)-carboxyliques et leurs derives
CH603587A5 (zh) *	1972-03-10	1978-08-31	Ciba Geigy Ag
JPS5665097A (en) *	1979-05-30	1981-06-02	Lion Corp	Manufacture of fatty acid lower alcohol ester
JPS58116466A (ja) *	1981-12-29	1983-07-11	Nippon Zoki Pharmaceut Co Ltd	新規キノリル酢酸誘導体及び該化合物を含有する医薬組成物
US4956372A (en) *	1987-10-02	1990-09-11	Kyorin Pharmaceutical Co., Ltd.	Cyclic anthranilic acid derivatives and process for their preparation
US5124325A (en) *	1989-06-13	1992-06-23	Kyorin Pharmaceutical Co., Ltd.	Therapeutic agents of metabolic bone disease

1992
- 1992-04-10 JP JP11673092A patent/JP3209568B2/ja not_active Expired - Fee Related
- 1992-04-15 ES ES92908279T patent/ES2184730T3/es not_active Expired - Lifetime
- 1992-04-15 EP EP92908279A patent/EP0538477B1/en not_active Expired - Lifetime
- 1992-04-15 CZ CS923651A patent/CZ282165B6/cs not_active IP Right Cessation
- 1992-04-15 HU HU9203870A patent/HU222522B1/hu not_active IP Right Cessation
- 1992-04-15 US US07/956,012 patent/US5359076A/en not_active Expired - Lifetime
- 1992-04-15 CA CA002085347A patent/CA2085347C/en not_active Expired - Fee Related
- 1992-04-15 KR KR1019920703236A patent/KR960007085B1/ko not_active IP Right Cessation
- 1992-04-15 DE DE69232812T patent/DE69232812T2/de not_active Expired - Fee Related
- 1992-04-15 DK DK92908279T patent/DK0538477T3/da active
- 1992-04-15 AU AU15549/92A patent/AU647612B2/en not_active Ceased
- 1992-04-15 SK SK3651-92A patent/SK282146B6/sk unknown
- 1992-04-15 AT AT92908279T patent/ATE226196T1/de not_active IP Right Cessation
- 1992-04-15 RO RO92-01558A patent/RO114615B1/ro unknown
- 1992-04-15 HU HU9203870A patent/HU9203870D0/hu unknown
- 1992-04-15 WO PCT/JP1992/000476 patent/WO1992018482A1/ja active IP Right Grant
- 1992-04-25 TW TW081103268A patent/TW203606B/zh active
- 1992-12-15 BG BG97173A patent/BG61262B1/bg unknown
- 1992-12-15 FI FI925697A patent/FI101300B1/fi active
- 1992-12-15 NO NO924854A patent/NO179174C/no unknown

Also Published As

Publication number	Publication date
DE69232812D1 (de)	2002-11-21
KR960007085B1 (ko)	1996-05-27
KR930700449A (ko)	1993-03-15
AU1554992A (en)	1992-11-17
BG97173A (bg)	1993-12-24
SK282146B6 (sk)	2001-11-06
JPH05125052A (ja)	1993-05-21
ATE226196T1 (de)	2002-11-15
FI925697A0 (fi)	1992-12-15
JP3209568B2 (ja)	2001-09-17
ES2184730T3 (es)	2003-04-16
EP0538477B1 (en)	2002-10-16
EP0538477A4 (en)	1993-02-12
TW203606B (zh)	1993-04-11
CZ365192A3 (en)	1993-08-11
WO1992018482A1 (en)	1992-10-29
HU9203870D0 (en)	1993-03-29
HU222522B1 (hu)	2003-08-28
NO179174B (no)	1996-05-13
NO924854L (no)	1993-02-16
BG61262B1 (en)	1997-04-30
AU647612B2 (en)	1994-03-24
FI101300B (fi)	1998-05-29
CA2085347A1 (en)	1992-10-17
NO924854D0 (no)	1992-12-15
EP0538477A1 (en)	1993-04-28
FI925697A (fi)	1992-12-15
HUT68184A (en)	1995-05-29
FI101300B1 (fi)	1998-05-29
NO179174C (no)	1996-08-21
CA2085347C (en)	2003-08-19
SK365192A3 (en)	2000-11-07
RO114615B1 (ro)	1999-06-30
US5359076A (en)	1994-10-25
DE69232812T2 (de)	2003-08-07
CZ282165B6 (cs)	1997-05-14

Publication	Publication Date	Title
DK0562956T3 (da)	1996-02-05	Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
DK0539204T3 (da)	1998-09-07	Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
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AR011174A1 (es)	2000-08-02	Compuestos de pirazina, composiciones farmaceuticas que los contienen, su uso en la peparacion de medicamentos y proceso para prepararlos
ES2054825T3 (es)	1994-08-16	Compuestos heterociclicos terapeuticos.
NO20060870L (no)	2006-04-07	Fluorsubstituert omega-karboksyaryldifenylurea for behandling og profylakse av sykdommer og tilstander
EA200200708A1 (ru)	2003-02-27	Производные бензазола и их применение в качестве модуляторов jnk
BR9803295A (pt)	2000-03-21	preparos e composições farmacêuticas contendo os mesmos.
DK0519327T3 (da)	2000-03-20	N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt
DK1320526T3 (da)	2010-10-18	Farmaceutisk aktive benzsulfonamidderivater som inhibitorer af protein-junkinaser
EP0372940A3 (en)	1991-03-06	Anti-inflammatory 2-furanones
ATE267826T1 (de)	2004-06-15	Pharmazeutisch wirksame sulfonyl hydrazid- derivate
DK0538477T3 (da)	2002-11-11	Hidtil ukendte cykliske aminophenyleddikesyrederivater, fremstilling deraf og immunreaktonskodulator, der indeholder disse som aktiv bestanddel
DK528789D0 (da)	1989-10-24	4-amino-3-acylquinolinderivater og deres anvendelse som inhibitorer af mavesyresekretion
CY1112057T1 (el)	2015-11-04	Θεραπευτικος παραγων για διαταραχη επαρκειας τροφης στο στομαχι
DK0521393T3 (da)	1996-07-22	Dichlofenac-cholinsalt, fremgangsmåde til fremstilling deraf og farmaceutiske præparater der indeholder det
DK0861250T3 (da)	2002-04-29	Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase
NO167029C (no)	1991-09-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinkarboksylsyrederivater
RU94037965A (ru)	1996-08-10	Производные бензоксазола в виде рацемата или отдельных энантиомеров и их фармацевтически приемлемые соли и фармацевтические композиции с ингибирующей биосинтез лейкотриенов активностью
FI802384A (fi)	1981-02-03	Nya 3-amino-1-benzoxepin-derivat och deras salter; foerfarande foer deras framstaellning samt laekemedel innehaollande dessa foereningar
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NO951812L (no)	1995-11-13	Pyrrolderivater, deres fremstilling og anvendelse
ES2123038T3 (es)	1999-01-01	Nuevos derivados pirrolo-tieno-pirazinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DK1240162T3 (da)	2003-08-11	3-imino-1,2-dithiolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse