DE69025834D1 - Antivirale Verbindungen - Google Patents

Antivirale Verbindungen

Info

Publication number
DE69025834D1
DE69025834D1 DE69025834T DE69025834T DE69025834D1 DE 69025834 D1 DE69025834 D1 DE 69025834D1 DE 69025834 T DE69025834 T DE 69025834T DE 69025834 T DE69025834 T DE 69025834T DE 69025834 D1 DE69025834 D1 DE 69025834D1
Authority
DE
Germany
Prior art keywords
antiviral compounds
preparation
treatment
methods
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69025834T
Other languages
English (en)
Inventor
Sylvia Margaret Tisdale
Tuttle Joel Van
Martin John Slater
Susan Mary Daluge
Wayne Howard Miller
Thomas Anthony Krenitsky
George Walter Koszalka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE69025834D1 publication Critical patent/DE69025834D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Local Oxidation Of Silicon (AREA)
  • Element Separation (AREA)
DE69025834T 1989-09-11 1990-09-07 Antivirale Verbindungen Expired - Lifetime DE69025834D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898920534A GB8920534D0 (en) 1989-09-11 1989-09-11 Antiviral compounds

Publications (1)

Publication Number Publication Date
DE69025834D1 true DE69025834D1 (de) 1996-04-18

Family

ID=10662891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69025834T Expired - Lifetime DE69025834D1 (de) 1989-09-11 1990-09-07 Antivirale Verbindungen

Country Status (19)

Country Link
EP (2) EP0671410A1 (de)
JP (1) JPH03145497A (de)
KR (1) KR910006293A (de)
AT (1) ATE135365T1 (de)
AU (1) AU644095B2 (de)
CA (1) CA2025009A1 (de)
DD (1) DD297650A5 (de)
DE (1) DE69025834D1 (de)
FI (1) FI904445A0 (de)
GB (1) GB8920534D0 (de)
HU (1) HUT54704A (de)
IE (1) IE903269A1 (de)
MY (1) MY130035A (de)
NZ (1) NZ235244A (de)
PL (1) PL164967B1 (de)
PT (1) PT95261A (de)
RU (2) RU2043361C1 (de)
TW (2) TW226333B (de)
ZA (1) ZA907187B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5670633A (en) * 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5914396A (en) * 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
WO1991015498A2 (en) * 1990-04-04 1991-10-17 Nycomed Imaging As Nucleoside derivatives
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5677437A (en) * 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5618704A (en) * 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5792844A (en) * 1990-07-27 1998-08-11 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent nitrogen atoms
WO1992011276A1 (en) * 1990-12-18 1992-07-09 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
US7119184B2 (en) 1991-08-12 2006-10-10 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US6307040B1 (en) 1992-03-05 2001-10-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5393841A (en) * 1993-11-09 1995-02-28 Shell Oil Company Dissimilar arm asymmetric radial or star block copolymers for adhesives and sealants
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
DK0917879T3 (da) * 1997-11-22 2002-11-04 Roche Diagnostics Gmbh Forbedret fremgangsmåde til stabilisering af proteiner
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
KR100965488B1 (ko) * 1998-02-25 2010-06-24 에모리 유니버시티 2'-플루오로뉴클레오사이드
ES2402597T3 (es) 2000-10-18 2013-05-07 Gilead Pharmasset Llc Nucleósidos modificados para el tratamiento de infecciones víricas y proliferación celular anormal
US7132453B2 (en) 2002-03-15 2006-11-07 Vanderbilt University Method of using prostacyclin to treat respiratory syncytial virus infections
WO2004044133A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Modified oligonucleotides for use in rna interference
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
WO2008109080A2 (en) * 2007-03-01 2008-09-12 Siemens Medical Solutions Usa, Inc. Nucleoside based proliferation imaging markers
WO2010101951A1 (en) 2009-03-02 2010-09-10 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
WO2011123621A2 (en) 2010-04-01 2011-10-06 Alnylam Pharmaceuticals Inc. 2' and 5' modified monomers and oligonucleotides
EP2937420A1 (de) * 2014-04-23 2015-10-28 Synbias Pharma AG Verfahren zur Synthese von Clofarabin
WO2018110643A1 (ja) * 2016-12-14 2018-06-21 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus

Also Published As

Publication number Publication date
PL164967B1 (pl) 1994-10-31
HUT54704A (en) 1991-03-28
TW246641B (de) 1995-05-01
RU2043361C1 (ru) 1995-09-10
PL286820A1 (en) 1991-04-22
MY130035A (en) 2007-05-31
ATE135365T1 (de) 1996-03-15
AU644095B2 (en) 1993-12-02
RU94002475A (ru) 1996-11-10
EP0417999A1 (de) 1991-03-20
TW226333B (de) 1994-07-11
DD297650A5 (de) 1992-01-16
NZ235244A (en) 1992-11-25
FI904445A0 (fi) 1990-09-10
AU6235090A (en) 1991-03-14
ZA907187B (en) 1992-05-27
IE903269A1 (en) 1991-03-27
KR910006293A (ko) 1991-04-29
EP0671410A1 (de) 1995-09-13
JPH03145497A (ja) 1991-06-20
EP0417999B1 (de) 1996-03-13
GB8920534D0 (en) 1989-10-25
CA2025009A1 (en) 1991-03-12
PT95261A (pt) 1991-05-22

Similar Documents

Publication Publication Date Title
DE69025834D1 (de) Antivirale Verbindungen
TW371660B (en) Therapeutic nucleosides a purine carbocyclic nucleosides for treatment of HIV and HBV infections
MY104043A (en) Therapeutic nucleosides.
ATE135363T1 (de) Nucleoside zur verwendung für die therapie
UA66744C2 (en) 5,6-dichlorobenzimidazole derivatives, methods for the preparation thereof, pharmaceutical composition and method for treatment of viral infections
MY107843A (en) Anti-viral compounds.
PT777669E (pt) Utilizacao de succinato de 4-(2-amino-6-(ciclopropilamino)-9h-purin-9-il)-2-ciclopenteno-1-metanol como agente antiviral
ES2105923A1 (es) Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv).
PT87004A (pt) Process for the preparation of compositions for the treatment of viral infections and composites 3'-azide-2',3'-didesoxy-in osine and 3'-fluoro-2',3'-didesoxyguanosine
PT81387A (en) Process for preparing pharmaceutical compositions containing 1--beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide useful for treating human viral disfases
DE69033252D1 (de) Therapeutische nukleoside
PT76903A (en) Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same
MX9303985A (es) Nucleosidos terapeuticos.
HU896136D0 (en) Process for producing compounds with antiviral effect and pharmaceutical compositions comprising same
DE69311135D1 (de) Zubereitungen, die acyclovir-ähnliche verbindungen und 2'-vinylsubstituierte nukleosidanaloge enthalten, zur behandlung viraler infektionen
ES2078380T3 (es) Oligofosfatos de accion antiviral.
FI943295A (fi) Piliostigma thonningii -uutteet, niiden käyttö ja niitä sisältävät formuloinnit
TH9840A (th) สารประกอบต้านไวรัส
TH10822EX (th) นิวคลีโอไซด์ซึ่งใช้ในการรักษาโรค
TW217986B (en) Compositions for the treatment of infection and disease caused by HBV
MX9706942A (es) Compuestos quimicos.
RU93050541A (ru) Соединения, выделенные из растений семейства и их производные, способ их получения и применение

Legal Events

Date Code Title Description
8332 No legal effect for de