DE60236212D1 - Neue isoform des gefässendothelzell wachstumshemmers (vegi) - Google Patents

Neue isoform des gefässendothelzell wachstumshemmers (vegi)

Info

Publication number
DE60236212D1
DE60236212D1 DE60236212T DE60236212T DE60236212D1 DE 60236212 D1 DE60236212 D1 DE 60236212D1 DE 60236212 T DE60236212 T DE 60236212T DE 60236212 T DE60236212 T DE 60236212T DE 60236212 D1 DE60236212 D1 DE 60236212D1
Authority
DE
Germany
Prior art keywords
vegi
isoforms
hemmer
total cellular
cellular growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236212T
Other languages
English (en)
Inventor
Luyuan Li
Hongguang Pan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Application granted granted Critical
Publication of DE60236212D1 publication Critical patent/DE60236212D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60236212T 2001-11-09 2002-11-12 Neue isoform des gefässendothelzell wachstumshemmers (vegi) Expired - Lifetime DE60236212D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33119001P 2001-11-09 2001-11-09
PCT/US2002/037426 WO2003039491A2 (en) 2001-11-09 2002-11-12 Novel isoforms of vascular endothelial cell growth inhibitor

Publications (1)

Publication Number Publication Date
DE60236212D1 true DE60236212D1 (de) 2010-06-10

Family

ID=23292954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60236212T Expired - Lifetime DE60236212D1 (de) 2001-11-09 2002-11-12 Neue isoform des gefässendothelzell wachstumshemmers (vegi)

Country Status (10)

Country Link
US (2) US7498407B2 (de)
EP (1) EP1487854B1 (de)
CN (1) CN100398551C (de)
AT (1) ATE466020T1 (de)
AU (1) AU2002359446B2 (de)
CA (1) CA2465953A1 (de)
DE (1) DE60236212D1 (de)
ES (1) ES2345329T3 (de)
RU (1) RU2316591C2 (de)
WO (1) WO2003039491A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE361313T1 (de) * 2000-01-25 2007-05-15 Oklahoma Med Res Found Allgemeines verfahren zur rückfaltung rekombinanter proteine
DE60236212D1 (de) 2001-11-09 2010-06-10 Univ Georgetown Neue isoform des gefässendothelzell wachstumshemmers (vegi)
CN1311076C (zh) * 2003-04-16 2007-04-18 普罗特奥姆技术公司 生产重组尿激酶的方法
WO2005058930A2 (en) * 2003-12-11 2005-06-30 Proteomtech Inc. Methods for production of recombinant vascular endothelial cell growth inhibitor
EP1691764A2 (de) * 2003-12-11 2006-08-23 Proteomtech, Inc. Verfahren zur behandlung von krebs mit vaskulärem endothelzell-wachstumshemmer oder vegi-192a
DK1919954T3 (en) 2005-08-30 2017-01-30 Univ Miami Immune modulating tumor necrosis factor receptor (TNFR25) - agonists, antagonists and immunotoxins
GB2446550B (en) * 2005-11-28 2010-12-08 Proteomtech Inc Methods for production of recombinant alpha1-antitrypsin
KR101248422B1 (ko) 2007-11-13 2013-04-09 테바 바이오파머수티컬스 유에스에이, 아이엔씨. Ｔｌ１ａ에 대한 인간화된 항체
CN101503474B (zh) * 2009-03-09 2012-07-04 中山大学 一种人血管内皮细胞生长抑制因子嵌合多肽及其制备方法和在靶向性抗肿瘤活性中的应用
CN101503697B (zh) * 2009-03-09 2013-08-07 中山大学 一种人血管内皮细胞生长抑制因子rhVEGI-192A的重组蛋白的制备方法
SG178125A1 (en) 2009-08-03 2012-03-29 Univ Miami Method for in vivo expansion of t regulatory cells
CN102453097A (zh) * 2010-10-27 2012-05-16 上海科新生物技术股份有限公司 抑制血管新生的融合蛋白vf及药物组合物和应用
CA2897826C (en) 2013-01-09 2022-09-27 Taylor H. Schreiber Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein
US9918669B2 (en) 2014-08-08 2018-03-20 Medtronic Xomed, Inc. Wireless nerve integrity monitoring systems and devices
CN107951862B (zh) * 2016-10-17 2021-03-12 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN111569051B (zh) * 2020-05-11 2021-10-22 中山大学 人血管内皮细胞抑制因子vegi-251在制备抗肿瘤药物中的应用

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
JP2752788B2 (ja) 1989-01-23 1998-05-18 カイロン コーポレイション 感染および過剰増殖障害の為の組換え療法
CA2357538A1 (en) 1989-03-21 1990-10-04 Wisconsin Alumni Research Foundation Expression of exogenous polynucleotide sequences in a vertebrate
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
WO1991002805A2 (en) 1989-08-18 1991-03-07 Viagene, Inc. Recombinant retroviruses delivering vector constructs to target cells
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
NZ237464A (en) 1990-03-21 1995-02-24 Depotech Corp Liposomes with at least two separate chambers encapsulating two separate biologically active substances
DK0648271T3 (da) 1991-08-20 2003-07-21 Us Gov Health & Human Serv Adenovirusmedieret overførsel af gener til mave-/tarmkanal
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
JPH07507689A (ja) 1992-06-08 1995-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 特定組織のターゲティング方法及び組成物
EP0644946A4 (de) 1992-06-10 1997-03-12 Us Health Gegen die inaktivierung durch menschliches serum resistente vektorpartikel.
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
EP1024198A3 (de) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenovirenvectors zur Gentherapie der Hämophilien
EP0695169B1 (de) 1993-04-22 2002-11-20 SkyePharma Inc. Multivesikuläre liposomen mit verkapseltem cyclodextrin und pharmakologisch wirksamen verbindungen sowie verfahren zu deren verwendung
EP0705344B8 (de) 1993-06-24 2006-05-10 Advec Inc. Adenovirus vektoren für gentherapie
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
ATE440957T1 (de) 1993-09-15 2009-09-15 Novartis Vaccines & Diagnostic Rekombinante alphavirus vektoren
CA2173975C (en) 1993-10-25 2007-06-12 Richard J. Gregory Recombinant adenoviral vector and methods of use
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
ES2149955T3 (es) 1993-11-16 2000-11-16 Skyepharma Inc Vesiculas con liberacion controlada de sustancias activas.
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
ES2297831T3 (es) 1994-05-09 2008-05-01 Oxford Biomedica (Uk) Limited Vectores retroviricos que presentan una tasa de recombinacion reducida.
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US6599719B2 (en) 1994-11-07 2003-07-29 Human Genome Sciences, Inc. Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
KR100507431B1 (ko) 1994-11-07 2005-12-21 휴먼 게놈 사이언시즈, 인코포레이티드 종양괴사인자-γ
WO1996017072A2 (en) 1994-11-30 1996-06-06 Chiron Viagene, Inc. Recombinant alphavirus vectors
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1997029212A1 (en) 1996-02-08 1997-08-14 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
ATE424463T1 (de) 1996-05-06 2009-03-15 Oxford Biomedica Ltd Rekombinationsunfähige retrovirale vektoren
EP0892047A3 (de) 1997-07-09 2000-03-08 Hoechst Marion Roussel Deutschland GmbH Humanes und murines Semaphorin L
US20020111325A1 (en) 1997-11-03 2002-08-15 Human Genome Sciences, Inc. VEGI, an inhibitor of angiogenesis and tumor growth
CN1174993C (zh) 1997-11-03 2004-11-10 人体基因组科学有限公司 Vegi,一种血管发生和肿瘤生长的抑制剂
US6146848A (en) 1998-07-23 2000-11-14 The Hong Kong University Of Science & Technology Bacterial expression system
AU4934099A (en) 1998-08-04 2000-02-28 Center For Advanced Science And Technology Incubation, Ltd. Method for enzymatic amplification of nucleic acid
AU5124500A (en) 1999-04-30 2000-11-17 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
ATE361313T1 (de) 2000-01-25 2007-05-15 Oklahoma Med Res Found Allgemeines verfahren zur rückfaltung rekombinanter proteine
PE20020908A1 (es) 2001-03-21 2002-10-26 Cell Therapeutics Inc Produccion recombinante de polimeros polianionicos y uso de de los mismos
DE60236212D1 (de) 2001-11-09 2010-06-10 Univ Georgetown Neue isoform des gefässendothelzell wachstumshemmers (vegi)
EP1691764A2 (de) * 2003-12-11 2006-08-23 Proteomtech, Inc. Verfahren zur behandlung von krebs mit vaskulärem endothelzell-wachstumshemmer oder vegi-192a

Also Published As

Publication number Publication date
CN1668630A (zh) 2005-09-14
RU2316591C2 (ru) 2008-02-10
US7750133B2 (en) 2010-07-06
WO2003039491A2 (en) 2003-05-15
ES2345329T3 (es) 2010-09-21
WO2003039491A3 (en) 2004-09-30
ATE466020T1 (de) 2010-05-15
EP1487854A2 (de) 2004-12-22
US20090227014A1 (en) 2009-09-10
CA2465953A1 (en) 2003-05-15
WO2003039491A8 (en) 2003-10-30
US7498407B2 (en) 2009-03-03
EP1487854A4 (de) 2006-01-04
CN100398551C (zh) 2008-07-02
US20030170242A1 (en) 2003-09-11
RU2004117536A (ru) 2005-04-20
AU2002359446B2 (en) 2008-12-04
EP1487854B1 (de) 2010-04-28

Similar Documents

Publication Publication Date Title
DE60236212D1 (de) Neue isoform des gefässendothelzell wachstumshemmers (vegi)
ATE526041T1 (de) Verfahren zur hemmung okularer vorgänge
FI962350A0 (fi) BPM-12, BMP-13 sekä niiden jännettä indusoivat koostumukset
PT1187918E (pt) Antagonistas de tek
DK1140173T3 (da) Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf
ECSP045468A (es) Nuevas proteínas de fusión con trombomodulina dirigidas contra factores tisulares como anticoagulantes
TR200100267T2 (tr) İkameli anilid bileşimleri ve yöntemler.
SG158141A1 (en) Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
ATE407698T1 (de) Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung
DE69735502D1 (de) Mutanten des lag-3 proteins, ihre expression und verwendung
ATE347611T1 (de) Automatischer apparat zum messen von wassertoxizität
ATE376428T1 (de) Metallkomplexverbindungen
EA200201138A1 (ru) Пептид, модулирующий рецептор тромбопоэтина
NO971341L (no) Promoter for reseptor tyrosinkinase TIE
ATE543833T1 (de) Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
DK1509618T3 (da) Autoimmune sygdomme og NADPH-oxidasedefekter
CY1109167T1 (el) Μεθοδος για την παρασκευη αυξητικης ορμονης και ανταγωνιστη αυτης εχοντας χαμηλοτερα επιπεδα ισομορφικων προσμειξεων αυτου
ATE306668T1 (de) Diagnose von brustkrebs unter verwendung von bcmp-7 als marker
NO20026286D0 (no) Nye peptider
PT723552E (pt) Oligopeptidos derivados de fragmentos de proteina reactiva c
DK1095275T3 (da) Endogen, konstitutivt aktiverede G-protein-koblede orphan-receptorer
DE60135489D1 (de) Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung
SE0202608D0 (sv) New sequences
AU4782501A (en) Angiogenic onchocerca volvulus proteins and uses thereof
CY1108517T1 (el) Σκεyασμα 2-μεθυλο-θειενο-βενζοδιαζεπiνης

Legal Events

Date Code Title Description
8364 No opposition during term of opposition