NO331013B1 - Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat - Google Patents

Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat

Info

Publication number
NO331013B1
NO331013B1 NO20040100A NO20040100A NO331013B1 NO 331013 B1 NO331013 B1 NO 331013B1 NO 20040100 A NO20040100 A NO 20040100A NO 20040100 A NO20040100 A NO 20040100A NO 331013 B1 NO331013 B1 NO 331013B1
Authority
NO
Norway
Prior art keywords
compounds
immunomodulatory
inflammatory
well
pharmaceutical preparations
Prior art date
Application number
NO20040100A
Other languages
English (en)
Other versions
NO20040100L (no
Inventor
Bernd Kramer
Johann Leban
Gabriel Garcia
Wael Saeb
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of NO20040100L publication Critical patent/NO20040100L/no
Publication of NO331013B1 publication Critical patent/NO331013B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/59—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
NO20040100A 2001-07-10 2004-01-09 Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat NO331013B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2001/007948 WO2003006424A1 (en) 2001-07-10 2001-07-10 Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
PCT/EP2002/007655 WO2003006425A2 (en) 2001-07-10 2002-07-09 Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Publications (2)

Publication Number Publication Date
NO20040100L NO20040100L (no) 2004-03-09
NO331013B1 true NO331013B1 (no) 2011-09-05

Family

ID=8164500

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040100A NO331013B1 (no) 2001-07-10 2004-01-09 Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat

Country Status (24)

Country Link
US (2) US7176241B2 (no)
EP (2) EP2093214A1 (no)
JP (1) JP2004536122A (no)
KR (2) KR20080093077A (no)
CN (1) CN100462352C (no)
AT (1) ATE451349T1 (no)
AU (1) AU2002325315C1 (no)
BR (1) BRPI0211055B8 (no)
CA (1) CA2452491C (no)
CY (1) CY1109886T1 (no)
DE (1) DE60234690D1 (no)
DK (1) DK1392642T3 (no)
ES (1) ES2337239T3 (no)
HU (1) HU229869B1 (no)
IL (2) IL159418A0 (no)
MX (1) MXPA04000224A (no)
NO (1) NO331013B1 (no)
NZ (1) NZ530304A (no)
PL (1) PL211388B1 (no)
PT (1) PT1392642E (no)
RU (1) RU2309946C2 (no)
SI (1) SI1392642T1 (no)
WO (2) WO2003006424A1 (no)
ZA (1) ZA200309887B (no)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
ES2440284T3 (es) 2002-11-14 2014-01-28 Thermo Fisher Scientific Biosciences Inc. ARNip dirigido a tp53
EP1541198A1 (en) * 2003-12-05 2005-06-15 4Sc Ag Cycloalkyl compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
WO2004056747A1 (en) * 2002-12-23 2004-07-08 4Sc Ag Dhodh-inhibitors and method for their identification
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
NZ541382A (en) * 2002-12-23 2009-04-30 4Sc Ag Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7247736B2 (en) 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
SE0400234D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New compounds, methods for their preparation and use thereof
US7605250B2 (en) 2004-05-12 2009-10-20 Dharmacon, Inc. siRNA targeting cAMP-specific phosphodiesterase 4D
EP1763346A4 (en) * 2004-05-21 2009-03-04 Uab Research Foundation COMPOSITION AND METHODS RELATING TO INHIBITORS OF PYRIMIDINE SYNTHESIS
WO2006022442A1 (ja) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
EP1798224A1 (en) * 2004-10-05 2007-06-20 Shionogi Co., Ltd. Biaryl derivative
JPWO2006051937A1 (ja) * 2004-11-15 2008-05-29 塩野義製薬株式会社 ヘテロ５員環誘導体
CN101437823B (zh) 2006-05-04 2014-12-10 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CN101563082A (zh) * 2006-09-05 2009-10-21 窦德献 治疗免疫介导性皮肤病的组合物和方法
ES2319596B1 (es) * 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ES2327372B1 (es) * 2007-04-23 2010-08-24 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ATE508108T1 (de) 2007-02-06 2011-05-15 Chelsea Therapeutics Inc Neue verbindungen, verfahren zu deren herstellung und deren verwendung
EP2100881A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Pyrimidyl- or pyridinylaminobenzoic acid derivatives
UY31272A1 (es) * 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
EP2135610A1 (en) * 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
WO2010052027A1 (en) * 2008-11-07 2010-05-14 4Sc Ag Combinational therapy comprising dhodh inhibitor and methotrexate for treating autoimmune disease
EP2230232A1 (en) 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
EP2228367A1 (en) 2009-03-13 2010-09-15 Almirall, S.A. Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
TWI530286B (zh) * 2009-05-04 2016-04-21 帕納特斯製藥格斯有限公司 作為抑制病毒化合物之抗發炎劑
EP2314577A1 (en) 2009-10-16 2011-04-27 Almirall, S.A. Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
BR112012012641A2 (pt) 2009-11-27 2020-08-11 Boehringer Ingelheim International Gmbh TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
US8686048B2 (en) * 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
WO2011163502A1 (en) * 2010-06-24 2011-12-29 Allergan, Inc. Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
EP2444086A1 (en) 2010-10-22 2012-04-25 Almirall, S.A. Combinations comprising DHODH inhibitors and COX inhibitors
EP2444088A1 (en) * 2010-10-22 2012-04-25 Almirall, S.A. Amino derivatives for the treatment of proliferative skin disorders
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US20140031383A1 (en) 2011-02-08 2014-01-30 Dana-Farber Cancer Institute, Inc. Methods for treatment of melanoma
US10016402B2 (en) 2011-02-08 2018-07-10 Children's Medical Center Corporation Methods for treatment of melanoma
US8492556B2 (en) * 2011-11-10 2013-07-23 Allergan, Inc. 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2015154820A1 (en) 2014-04-11 2015-10-15 Panoptes Pharma Gmbh Anti-inflammatory agents as virostatic compounds
WO2016200778A1 (en) * 2015-06-08 2016-12-15 Children's Medical Center Corporation Methods for treatment of melanoma
WO2017075559A1 (en) 2015-10-30 2017-05-04 E. I. Du Pont De Nemours And Company Dihydroorotate dehydrogenase inhibitor compositions effective as herbicides
MX2018008169A (es) * 2015-12-30 2019-02-20 Agios Pharmaceuticals Inc Tratamiento de tumores que incorpora isocitrato deshidrogenasa mutante.
AU2017276758A1 (en) 2016-06-10 2018-11-08 Boehringer Ingelheim International Gmbh Combinations of Linagliptin and metformin
CN110248937B (zh) 2016-10-27 2022-03-29 拜耳股份有限公司 4,5-环状1,2,4-三唑酮
WO2018136009A1 (en) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Combination therapy
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
PL3615027T3 (pl) * 2017-04-24 2022-01-03 Aurigene Discovery Technologies Limited Sposoby zastosowania trójpodstawionych pochodnych benzotriazolu jako inhibitorów oksygenazy dihydroorotanowej
KR20200090204A (ko) 2017-11-23 2020-07-28 이뮤닉 아게 만성 염증성 및/또는 자가면역 질환의 예방 또는 치료에 사용하기 위한 비도플루디무스의 투여량 레지멘
TWI818954B (zh) 2018-02-20 2023-10-21 法商施維雅藥廠 三取代之苯并三唑衍生物的使用方法
UA128135C2 (uk) 2018-03-16 2024-04-17 Іммунік Аґ Поліморфи кальцієвої солі як протизапальні, імуномодулюючі та антипроліферативні засоби
CN111018836A (zh) * 2019-12-31 2020-04-17 南京福斯特牧业科技有限公司 一种增效磺胺类药物作用的嘧啶制剂及其制法
CA3176008A1 (en) 2020-04-21 2021-10-28 Manfred Groppel Vidofludimus for use in the treatment or prevention of viral diseases
IL307559A (en) 2021-04-09 2023-12-01 Immunic Ag Deuterated dihydroorotate dihydrogenase (DHODH) inhibitors
TW202333706A (zh) 2021-11-01 2023-09-01 德商埃慕尼克股份公司 Ｎ—羥基胞磷膽鹼（ｃｉｔｉｃｏｌｉｎｅ）化合物的醫藥用途
AR128080A1 (es) 2021-12-23 2024-03-20 Immunic Ag Inhibidores de dhodh que contienen un bioisóstero de ácido carboxílico
WO2023232884A1 (en) 2022-06-01 2023-12-07 Immunic Ag Treatment of ulcerative colitis comprising vidofludimus or a pharmaceutically acceptable salt thereof
WO2024200872A1 (en) 2023-03-29 2024-10-03 Immunic Ag Vidofludimus and related structures acting as nurr1 agonists

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726881A (en) 1970-12-28 1973-04-10 Richter Gedeon Vegyeszet N-aminoxy-acetyl-n'-isonicotinoyl-hydrazine and the pharmaceutically acceptable salts thereof
JPS50121428A (no) * 1974-03-12 1975-09-23
NL186239B (nl) 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
IL56012A (en) * 1977-11-29 1983-07-31 Takeda Chemical Industries Ltd N-(2-fluoro-4-bromo(or chloro)phenyl)-3,4,5,6-tetrahydrophthalamic acid derivatives,their preparation,and herbicidal compositions comprising them
JPS54154737A (en) * 1978-05-25 1979-12-06 Mitsubishi Chem Ind Ltd Cyclohexenedicarboxylic acid diamide and herbicide
JPS5547668A (en) 1978-09-30 1980-04-04 Taisho Pharmaceut Co Ltd Epoxysuccinamic acid
JPS55157547A (en) * 1979-05-28 1980-12-08 Takeda Chem Ind Ltd Tetrahydrophthalamide derivative, its preparation and herbicide
AU1526483A (en) * 1982-06-14 1983-12-22 Nippon Kayaku Kabushiki Kaisha N-substituted-3,4,5,6-tetrahydrophthalamic acids
JPS59118750A (ja) * 1982-12-27 1984-07-09 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
DE3332780A1 (de) 1983-09-10 1985-03-28 Hoechst Ag, 6230 Frankfurt 6-sulfoxyphenolderivate, ihre herstellung und ihre verwendung als cytoprotekiva
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
IL110427A (en) 1993-08-11 1998-10-30 Rohm & Haas Process for the preparation of 1,2-diacyl-T-2-alkyl hydrazides
GB9320299D0 (en) 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
AUPN191295A0 (en) 1995-03-23 1995-04-27 Unisearch Limited Microbiocide or microbial regulator
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
EP0994961B1 (en) 1997-06-18 2006-10-18 Montana State University - Bozeman Homoserine lactones biofilm regulating compounds and their methods of use
GB9725599D0 (en) 1997-12-04 1998-02-04 Univ Nottingham Control of biofilm formation
WO1999038846A1 (en) 1998-01-30 1999-08-05 Procept, Inc. Immunosuppressive agents
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
AUPP303498A0 (en) 1998-04-17 1998-05-14 Unisearch Limited Inhibition of gram positive bacteria
WO1999055368A1 (en) 1998-04-27 1999-11-04 President And Fellows Of Harvard College Regulation of biofilm formation
AU752209B2 (en) 1998-08-27 2002-09-12 Dow Agrosciences Llc Process for substituted hydrazides using carboxylic acids
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
GB2356398A (en) 1999-11-18 2001-05-23 Lilly Dev Ct S A Preparation of arylsulfamides
EP1246795B1 (en) 2000-01-13 2007-10-31 Amgen Inc. Antibacterial agents
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Also Published As

Publication number Publication date
SI1392642T1 (sl) 2010-04-30
RU2004103741A (ru) 2005-06-20
US20030203951A1 (en) 2003-10-30
EP1392642A2 (en) 2004-03-03
CN100462352C (zh) 2009-02-18
US7176241B2 (en) 2007-02-13
JP2004536122A (ja) 2004-12-02
BR0211055A (pt) 2004-07-20
RU2309946C2 (ru) 2007-11-10
HUP0400998A3 (en) 2009-01-28
EP2093214A1 (en) 2009-08-26
BRPI0211055B1 (pt) 2018-03-20
KR20080093077A (ko) 2008-10-17
KR20040029357A (ko) 2004-04-06
BRPI0211055B8 (pt) 2021-05-25
IL159418A (en) 2011-03-31
WO2003006424A1 (en) 2003-01-23
ZA200309887B (en) 2004-07-20
CA2452491A1 (en) 2003-01-23
DE60234690D1 (de) 2010-01-21
KR100891571B1 (ko) 2009-04-03
NZ530304A (en) 2006-02-24
HU229869B1 (en) 2014-10-28
PL366590A1 (en) 2005-02-07
CA2452491C (en) 2013-04-30
WO2003006425A2 (en) 2003-01-23
NO20040100L (no) 2004-03-09
ES2337239T3 (es) 2010-04-22
AU2002325315C1 (en) 2009-03-26
DK1392642T3 (da) 2010-03-08
US20060199856A1 (en) 2006-09-07
AU2002325315B2 (en) 2008-08-07
PT1392642E (pt) 2010-02-24
WO2003006425A3 (en) 2003-11-27
HUP0400998A2 (hu) 2004-09-28
ATE451349T1 (de) 2009-12-15
US7423057B2 (en) 2008-09-09
CY1109886T1 (el) 2014-09-10
MXPA04000224A (es) 2005-07-25
PL211388B1 (pl) 2012-05-31
EP1392642B1 (en) 2009-12-09
IL159418A0 (en) 2004-06-01
CN1525954A (zh) 2004-09-01
WO2003006425A9 (en) 2004-02-26

Similar Documents

Publication Publication Date Title
NO331013B1 (no) Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat
ECSP045104A (es) Ligandos de los receptores de los cannabinoides
ATE302775T1 (de) Carbolinderivate
NO20055219L (no) Nye forbindelser
BR0314688A (pt) Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina
EA200301142A1 (ru) Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
SE0400043D0 (sv) New compounds
ATE346067T1 (de) Carbolinderivate
CY1111851T1 (el) Αρωματικες ενωσεις ως αντι-φλεγμονωδεις, ανοσορυθμιστικοι και αντι-πολλαπλασιαστικοι παραγοντες
IT1311922B1 (it) Composti farmaceutici.
ATE332903T1 (de) Kondensierte pyridoindolderivate
SE0101932D0 (sv) Pharmaceutical combinations
NO20054787L (no) Indenderivater som farmasotiske midler
NO20040881L (no) Orale antidiabetes midler.
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
NO20060718L (no) Substituerte tiofoner og deres anvendelse
ATE299871T1 (de) Neue zyklische depsipeptid pf1022 derivate
ATE274515T1 (de) Pyrazolopyridinderivate
DE60222465D1 (de) Pyrazolopyridin-derivate als antiherpesmittel
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
NO20053562L (no) Nye aminobenzofenonforbindelser
DK1541553T3 (da) Indolinforbindelse samt medicinsk anvendelse deraf
DE50310743D1 (de) Wässrige formulierungen von (2-hydroxymethyl-indanyl-4-oxy)-phenyl-4,4,4- trifluorbutan-1-sulfonat
CY1105981T1 (el) Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees