DE540767T1 - Behandlung und Vorbeugung von von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten - Google Patents
Behandlung und Vorbeugung von von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-AntagonistenInfo
- Publication number
- DE540767T1 DE540767T1 DE0540767T DE91118745T DE540767T1 DE 540767 T1 DE540767 T1 DE 540767T1 DE 0540767 T DE0540767 T DE 0540767T DE 91118745 T DE91118745 T DE 91118745T DE 540767 T1 DE540767 T1 DE 540767T1
- Authority
- DE
- Germany
- Prior art keywords
- paf
- lyso
- treatment
- antagonists
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000020016 psychiatric disease Diseases 0.000 title claims abstract 4
- 230000002265 prevention Effects 0.000 title claims 2
- 239000005557 antagonist Substances 0.000 title abstract 3
- 230000001404 mediated effect Effects 0.000 title abstract 2
- VLBPIWYTPAXCFJ-XMMPIXPASA-O Lyso-PAF C-16-d4 Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](O)COP(O)(=O)OCC[N+](C)(C)C VLBPIWYTPAXCFJ-XMMPIXPASA-O 0.000 title 1
- 108700020675 O-deacetyl platelet activating factor Proteins 0.000 title 1
- 229930184727 ginkgolide Natural products 0.000 claims abstract 4
- 239000003848 thrombocyte activating factor antagonist Substances 0.000 claims abstract 3
- 108700023400 Platelet-activating factor receptors Proteins 0.000 claims abstract 2
- 102000030769 platelet activating factor receptor Human genes 0.000 claims abstract 2
- JAOUCUCEKMTRCE-UHFFFAOYSA-N 105219-59-8 Chemical compound ClC1=CC=CC=C1C(C=1C=C(CCC(=O)N2CCOCC2)SC=1N12)=NCC1=NN=C2C1CC1 JAOUCUCEKMTRCE-UHFFFAOYSA-N 0.000 claims 1
- 208000018152 Cerebral disease Diseases 0.000 claims 1
- JGPJQFOROWSRRS-UHFFFAOYSA-N LSM-2613 Chemical compound S1C=2N3C(C)=NN=C3CN=C(C=3C(=CC=CC=3)Cl)C=2C=C1CCC(=O)N1CCOCC1 JGPJQFOROWSRRS-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000036753 Schizophrenia, disorganised type Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000003340 mental effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (1)
- EP No.91118745.8-1216, /jPublication No. 0540 767 Al DF/FPnSZfl7G7TiDr.med Ruth-Maria Korth yL-/LT U dfU/O/UPalestrinastr. 7A
D-80639 MünchenAnspruch 1:Verwendung von einer wirksamen Menge von mindestens einem Paf Antagonisten gegen Lyso paf Rezeptoren, ausgewählt aus der Gruppe der Ginkgolide, rac-3-(N-n-Octadecy!-carbamoyl-oxy)-2-methoxypropyl-2-thiazolioethyl phosphat (CV 3988) oder 3-(4-(2-Chlorphenyl)-9-methyl-6H-thieno-(3,2-f) (1,2,4) triazolo-(4,3-a)-(1,4)-diazepin-2yl)-1-(4-morpholinyl)-1-propanon (WEB 2086), (3-4-(2-Chlorphenyl)-9-cyclopropyl-6H-thieno-(3,2-f])-(l,2,4)-triazolo-(4,3-a) (1,4) diazepin-2yl)-1-(4-morpholinyl)-l-propanon (WEB 2098) und Tetrahydro-4,7,8,10-methyl-(chloro-2-phenyl)-6-[dimethoxy-3,4-phenyt)-thio]-methylthiocarbonyl-9-pyrido-(4',3'-4,-5)-thieno-[3,2-f]-triazolo-1,2,4-[4,3-a]-diazepin-1,4 (BN 50739) für die Herstellung einer pharmazeutischen Komposition zur Behandlung und Vorbeugung von Psychosen, paranoiden Syndromen, Hebephrenia, mentalen Erkrankungen und zerebralen Erkrankungen, die von einem erhöhten Gehalt von Lyso paf begfeitet sind.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91118745A EP0540767B9 (de) | 1991-11-04 | 1991-11-04 | Behandlung und Vorbeugung von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
DE540767T1 true DE540767T1 (de) | 2001-10-25 |
Family
ID=8207297
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0540767T Pending DE540767T1 (de) | 1991-11-04 | 1991-11-04 | Behandlung und Vorbeugung von von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten |
DE69133083T Expired - Lifetime DE69133083C5 (de) | 1991-11-04 | 1991-11-04 | Behandlung und Vorbeugung von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69133083T Expired - Lifetime DE69133083C5 (de) | 1991-11-04 | 1991-11-04 | Behandlung und Vorbeugung von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten |
Country Status (6)
Country | Link |
---|---|
US (3) | US5346894A (de) |
EP (1) | EP0540767B9 (de) |
JP (1) | JPH06305981A (de) |
AT (1) | ATE221779T1 (de) |
DE (2) | DE540767T1 (de) |
ES (1) | ES2181665T3 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530023A (en) * | 1987-10-20 | 1996-06-25 | Korth; Ruth | Production of binding sites for PAF, PAF analogues and PAF antagonists in endothelial cells |
US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
US6274621B1 (en) * | 1995-11-09 | 2001-08-14 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ginkgolides for inhibition of membrane expression of benzodiazepine receptors |
US5854279A (en) * | 1996-06-04 | 1998-12-29 | Eisai Co., Ltd | Therapeutic agent for dermatosis |
US7078434B1 (en) * | 1999-08-12 | 2006-07-18 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Use of Ginkgo extract |
JP4733801B2 (ja) * | 1999-08-23 | 2011-07-27 | 丸善製薬株式会社 | エストロゲン様作用剤および皮膚化粧料 |
US6583152B2 (en) * | 2001-04-30 | 2003-06-24 | Dexgen Pharmaceuticals, Inc. | Composition for reducing the risk or progression of cardiovascular diseases |
US20050032713A1 (en) * | 2002-03-27 | 2005-02-10 | Wurtman Richard J. | Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents |
DE102005062417A1 (de) * | 2005-12-27 | 2007-08-23 | Korth, Ruth-Maria, Dr.med. | Kompositionen mit spezifischen und unspezifischen Lipidantagonisten |
US11039997B2 (en) | 2005-12-27 | 2021-06-22 | Ruth-Maria Korth | Cosmetic, dermatic, protective compositions comprising phospholipids, lecithins with peptides and at least one acetylating compound |
JP5982676B2 (ja) * | 2011-02-28 | 2016-08-31 | 学校法人 いわき明星大学 | 抗paf活性を有するビオチニル化ペプチド化合物 |
DE202011108417U1 (de) * | 2011-11-29 | 2012-03-01 | Ruth-Maria Korth | Örtliche und dietätische Kompositionen ohne Etherlipide, Etherphospholipide, Alkylradikale, die geeignet sind für sensible Personen |
CN108096241B (zh) * | 2017-11-24 | 2020-06-16 | 江苏康缘药业股份有限公司 | 银杏内酯组合物的医药用途 |
DE202019003092U1 (de) | 2019-07-24 | 2020-01-17 | Ruth-Maria Korth | Test zur Bestimmung von Proteophospholipiden und FIDA-Formeln zur Bestimmung von Schutzfaktoren , die mit Substraten auszugleichen sind |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8705890A3 (es) * | 1971-06-18 | 1986-11-16 | Yoshitomi Pharmaceutical | Un metodo de preparacion de compuesto de triazolotienodiaze-pina |
DE3338995A1 (de) * | 1983-10-27 | 1985-05-09 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Bilobalid enthaltende arzneimittel |
DE2732921A1 (de) * | 1977-07-21 | 1979-02-08 | Boehringer Sohn Ingelheim | Neue substituierte 1-acyl-piperidino- bzw. -piperazino-4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4- diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
US4183912A (en) * | 1978-01-16 | 1980-01-15 | American Home Products Corporation | Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine |
DE2830782A1 (de) * | 1978-07-13 | 1980-01-24 | Boehringer Sohn Ingelheim | Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
JPS6045518A (ja) * | 1983-08-22 | 1985-03-12 | Takeda Chem Ind Ltd | 抗シヨツク剤 |
US4540709A (en) * | 1983-10-13 | 1985-09-10 | Merck & Co., Inc. | Method for treatment of diseases mediated by PAF using 5-allyl-2-(3,4-Dimethoxyphenyl)-3a,α-methoxy-3-methyl-2,3,3a,6-tetrahydro-6-oxobenzofuran |
US4595693A (en) * | 1984-06-04 | 1986-06-17 | Merck & Co., Inc. | Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
GB8418424D0 (en) * | 1984-07-19 | 1984-08-22 | Scras | Inhibition of platelets aggregation |
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
DE3778559D1 (de) * | 1986-01-21 | 1992-06-04 | Boehringer Ingelheim Kg | Thieno-1,4-diazepine. |
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
JPS63225373A (ja) * | 1986-07-24 | 1988-09-20 | Sumitomo Pharmaceut Co Ltd | 新規チアゾリジン−4−オン誘導体およびその酸付加塩 |
SU1681729A3 (ru) * | 1986-07-25 | 1991-09-30 | Берингер Ингельгейм Кг (Фирма) | Способ получени производных 1,4-бензодиазепина |
DE3710921C2 (de) * | 1986-10-21 | 1996-09-26 | Korth Ruth | Verwendung der Gingkolide BN 52020, BN 52021 und BN 52063 zur Behandlung von Arteriosklerose |
DE3735524C2 (de) * | 1986-10-21 | 1996-07-11 | Korth Ruth Maria | Verfahren zur Bestimmung des paf-Acether- oder Peak X-Gehaltes von Blut |
DE3716004A1 (de) * | 1987-05-13 | 1988-11-24 | Bischof Hubert | Sicherheitsfolie, deren verwendung und mit dieser hergestelltes sicherheitsglas |
DE4244265C2 (de) * | 1992-12-28 | 1999-08-12 | Korth Ruth Maria | Verwendung von Paf-Antagonisten gegen die neue Ausbildung von Paf-Bindungsstellen auf endothelialen Zellen zur Behandlung oder Vorbeugung des Hyperinsulinismus |
DE3735525C2 (de) * | 1987-10-20 | 1997-02-20 | Korth Ruth Maria | Verfahren zur Bestimmung der Wirksamkeit von paf-Acether-Rezeptor-Antagonisten |
GB8725871D0 (en) * | 1987-11-04 | 1987-12-09 | Scras | Ginkgolide derivatives |
DE8716044U1 (de) * | 1987-12-04 | 1988-03-24 | Lewitz, Reinwald, 3100 Celle | Einbau-Häng-Globus |
US5334592A (en) * | 1988-04-27 | 1994-08-02 | Schering Corporation | Certain PAF antagonist antihistamine combinations and methods |
US5147864A (en) * | 1988-12-19 | 1992-09-15 | American Cyanamid Company | Bis-arylphosphate ester antagonists of platelet activating factor |
HUT60631A (en) * | 1989-05-05 | 1992-10-28 | North Sydney Area Health Serv | Process for producing pharmaceutical compositions suitable for increasing fertility |
IT1238684B (it) * | 1990-02-09 | 1993-09-01 | Indena Spa | Derivati del bilobalide,loro usi e formulazioni che li contegono |
ATE195653T1 (de) * | 1990-06-06 | 2000-09-15 | Ruth Korth | Behandlung von erkrankungen mit paf-antagonisten und verfahren zur bestimmung deren wirksamkeit |
-
1991
- 1991-11-04 DE DE0540767T patent/DE540767T1/de active Pending
- 1991-11-04 AT AT91118745T patent/ATE221779T1/de not_active IP Right Cessation
- 1991-11-04 EP EP91118745A patent/EP0540767B9/de not_active Expired - Lifetime
- 1991-11-04 ES ES91118745T patent/ES2181665T3/es not_active Expired - Lifetime
- 1991-11-04 DE DE69133083T patent/DE69133083C5/de not_active Expired - Lifetime
-
1992
- 1992-10-28 US US07/969,674 patent/US5346894A/en not_active Expired - Fee Related
- 1992-11-04 JP JP4319511A patent/JPH06305981A/ja active Pending
-
1994
- 1994-06-17 US US08/261,765 patent/US5605927A/en not_active Expired - Lifetime
-
1996
- 1996-12-09 US US08/761,938 patent/US5852052A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5852052A (en) | 1998-12-22 |
DE69133083C5 (de) | 2007-05-31 |
EP0540767B1 (de) | 2002-08-07 |
EP0540767B9 (de) | 2004-12-22 |
US5346894A (en) | 1994-09-13 |
DE69133083T2 (de) | 2003-05-08 |
ATE221779T1 (de) | 2002-08-15 |
ES2181665T3 (es) | 2003-03-01 |
JPH06305981A (ja) | 1994-11-01 |
EP0540767A1 (de) | 1993-05-12 |
US5605927A (en) | 1997-02-25 |
DE69133083D1 (de) | 2002-09-12 |
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