DD262662A5 - Verfahren zur herstellung von 13 beta-milbemycin-derivaten - Google Patents

Verfahren zur herstellung von 13 beta-milbemycin-derivaten Download PDF

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Publication number
DD262662A5
DD262662A5 DD85308111A DD30811185A DD262662A5 DD 262662 A5 DD262662 A5 DD 262662A5 DD 85308111 A DD85308111 A DD 85308111A DD 30811185 A DD30811185 A DD 30811185A DD 262662 A5 DD262662 A5 DD 262662A5
Authority
DD
German Democratic Republic
Prior art keywords
formula
milbemycin
group
alkyl
compounds
Prior art date
Application number
DD85308111A
Other languages
German (de)
English (en)
Inventor
Bruno Frei
Anthony C O'sullivan
Original Assignee
Ciba-Geigy Ag,Ch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba-Geigy Ag,Ch filed Critical Ciba-Geigy Ag,Ch
Publication of DD262662A5 publication Critical patent/DD262662A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD85308111A 1984-12-04 1985-12-03 Verfahren zur herstellung von 13 beta-milbemycin-derivaten DD262662A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH575084 1984-12-04

Publications (1)

Publication Number Publication Date
DD262662A5 true DD262662A5 (de) 1988-12-07

Family

ID=4298719

Family Applications (2)

Application Number Title Priority Date Filing Date
DD85308111A DD262662A5 (de) 1984-12-04 1985-12-03 Verfahren zur herstellung von 13 beta-milbemycin-derivaten
DD85283626A DD250457A5 (de) 1984-12-04 1985-12-03 Mittel zur bekaempfung von parasiten an pflanzen und insekten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD85283626A DD250457A5 (de) 1984-12-04 1985-12-03 Mittel zur bekaempfung von parasiten an pflanzen und insekten

Country Status (20)

Country Link
US (1) US4696945A (da)
EP (1) EP0184173B1 (da)
JP (1) JPH072748B2 (da)
CN (1) CN85109491A (da)
AU (1) AU584950B2 (da)
CA (1) CA1261823A (da)
DD (2) DD262662A5 (da)
DE (1) DE3587746D1 (da)
DK (1) DK559985A (da)
ES (3) ES8704473A1 (da)
FI (1) FI854773A (da)
GB (1) GB2167751B (da)
GR (1) GR852893B (da)
HU (1) HUT39739A (da)
IL (1) IL77198A (da)
MA (1) MA20583A1 (da)
NZ (1) NZ214425A (da)
PT (1) PT81591B (da)
ZA (1) ZA859247B (da)
ZW (1) ZW21785A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI860233A (fi) * 1985-01-22 1986-07-23 Ciba Geigy Ag 13 -alkyl-milbemycinderivat foer bekaempning av parasiter hos djur och vaexter.
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
EP0235085A1 (de) * 1986-02-20 1987-09-02 Ciba-Geigy Ag 13-Beta-Zuckerderivate von Milbemycinen, deren Herstellung und Verwendung gegen Ekto-und Endoparasiten am Nutztier oder an der Nutzpflanze
NZ219575A (en) * 1986-03-12 1990-04-26 Glaxo Group Ltd Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions
EP0240274A3 (en) * 1986-04-03 1990-03-14 Merck & Co. Inc. Avermectins as growth promotant agents
DE3778768D1 (de) * 1986-07-02 1992-06-11 Ciba Geigy Ag Pestizide.
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US5212322A (en) * 1986-12-11 1993-05-18 Sankyo Company, Limited Macrolide compounds, their preparation and their use
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
DE3880088T2 (de) * 1987-11-09 1993-07-22 Pfizer Ethylierte avermectine.
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
TW202452B (da) * 1989-12-01 1993-03-21 Ciba Geigy Ag
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5114930A (en) * 1990-05-14 1992-05-19 Merck & Co., Inc. Avermectin derivatives with a spacer inserted between the disaccharide and the aglycone useful as antiparasitic agents
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
EP0530901A1 (en) * 1991-09-04 1993-03-10 Merck & Co. Inc. 13-beta-O-methoxymethyl-22,23-dihydro avermectin B1A/B1B aglycone
JP2591552B2 (ja) * 1991-10-04 1997-03-19 三共株式会社 １５−ヒドロキシミルベマイシン誘導体及びその製法
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5461168A (en) * 1992-09-01 1995-10-24 Sankyo Company, Limited Processes for the production of 13-ether derivatives of milbemycins, and intermediates therefor
EP0810823B1 (en) 1995-02-24 2001-03-14 Novartis AG Composition for controlling parasites
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
JP2010526065A (ja) * 2007-05-03 2010-07-29 メリアル リミテッド Ｃ−１３アルコキシエーテルマクロライド化合物及びフェニルピラゾール化合物を含む組成物
US7919522B2 (en) 2007-05-03 2011-04-05 Merial Limited Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
JP5740676B2 (ja) * 2013-10-17 2015-06-24 メリアル リミテッド Ｃ−１３アルコキシエーテルマクロライド化合物及びフェニルピラゾール化合物を含む組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
JPS5461167A (en) * 1977-10-11 1979-05-17 Glaxo Group Ltd Novel substituted heterocyclic compounds* their manufacture and medical composition containing them
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use

Also Published As

Publication number Publication date
AU5071985A (en) 1986-06-12
GB2167751A (en) 1986-06-04
EP0184173B1 (de) 1994-02-02
US4696945A (en) 1987-09-29
ES8704473A1 (es) 1987-04-01
EP0184173A3 (en) 1989-03-15
ES556927A0 (es) 1987-10-01
ZA859247B (en) 1986-07-30
PT81591B (de) 1987-10-16
FI854773A (fi) 1986-06-05
NZ214425A (en) 1988-05-30
MA20583A1 (fr) 1986-07-01
ES8708232A1 (es) 1987-10-01
GB2167751B (en) 1988-04-27
DD250457A5 (de) 1987-10-14
DK559985A (da) 1986-06-05
CN85109491A (zh) 1986-07-23
ZW21785A1 (en) 1986-07-02
GB8529637D0 (en) 1986-01-08
HUT39739A (en) 1986-10-29
IL77198A (en) 1989-06-30
DE3587746D1 (de) 1994-03-17
PT81591A (de) 1986-01-01
ES556926A0 (es) 1987-10-01
GR852893B (da) 1986-04-01
ES8708233A1 (es) 1987-10-01
DK559985D0 (da) 1985-12-03
EP0184173A2 (de) 1986-06-11
FI854773A0 (fi) 1985-12-02
JPH072748B2 (ja) 1995-01-18
ES549508A0 (es) 1987-04-01
JPS61178986A (ja) 1986-08-11
CA1261823A (en) 1989-09-26
AU584950B2 (en) 1989-06-08

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Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee