CN1942160A - Container for constituting a formulation in liquid form - Google Patents

Abstract

A container (70) for constituting a formulation in liquid form, comprises an elongate outer body (71) split into a first section (72) and a second section (73), along the longitudinal axis thereof, The container (70) has an inner chamber (77) divided into a first compartment (78) and a second compartment (79) by a seal (80). Seal (80) is movable in use between a closed position, wherein the first compartment 78 and the second compartment are sealed thereby, to an open position, wherein the first compartment (78) and the second compartment (79) are unsealed and any contents therein are free to mix together in the inner chamber (77) to form the formulation. The seal (80) is movable from the closed position to the open position by rotation of the first section (72) relative to the second section (73), and the volume of the inner chamber (77) remains unchanged following unsealing. Once the seal (80) has been moved to the open position it is retained in that position. Reversal of the rotational movement causes an outer cover (74) to become detached from a tear strip (75), permitting the outer cover (74) to be removed and the formulation to be capable of being delivered from the container (70). A formulation administered from the container (70) can ensure, for example, that a precise dose of an active ingredient is delivered to a patient, where the formulation is a pharmaceutical product.

Description

Be used to form the container of formulation in liquid form

Technical field

The present invention relates to liquid preparation, the component that forms this preparation was combined before using, and for example, this is because if store with combining form, and these components just do not have essential activity or stable.

On the other hand, the present invention relates to be used for the pharmaceutical preparation of oral administration, be specifically related to the pharmaceutical preparation that directly from selling container, to draw.

Background technology

The medicine that is used for oral administration is capsule, granule, powder, tablet or other solid dosage forms normally, and they be not difficult to swallow in drinking water or the beverage.

When medicine during, must use soupspoon or other instruments for the medicine of aequum being delivered in the mouth, even must use hands with administrations such as liquid, syrup.

Gerontal patient or have the individuality of special requirement and difficulty often takes place the child when carrying out Drug therapy.For example, these people may be reluctant to swallow or be difficult to swallow conventional peroral dosage form.

Those take care of the people of senior people, particularly professional health worker, and the change administering mode that is under an embargo legally, they have to assist administration according to the explanation of manufacturer.But for the above reasons, these professional health workers may have to change medicine under the situation of subsidiary legal consequence, and for example broken or crushing tablet accepts to guarantee the effectively regulation medicine of the amount of treatment with the patient who guarantees them.

Another problem of conventional medicine is that it has taste beastly usually.Although can use coating, sugar-coat for example, covering the taste of active component or excipient, but senior people or other patient often chew these medicines and expose active component beastly or excipient, this can cause medicine to spue from mouth, therefore makes the patient can not get required dosage.

Many countries in the world are difficult to find the water supply of cleaning.Therefore, if medicine must and liquid use together, the people who takes medicine so needs the water medicine of swallowing through regular meeting, perhaps or even dissolved substance.

Equally in natural disaster for example under the situation of earthquake and flood, water supply meeting is temporarily interrupted, and this just exists once more to need not the demand that people have the medicine of clean water supply on hand.

In already provided system, for storing purpose the active component of powder form is put into the container of hermetically-sealed construction, and when needs are taken active component with liquid form, this active component is released in the liquid medium of container.But the problem that this system ran into is that active component is easy to caking in hermetically-sealed construction, and when needs, active component can not all be discharged in the liquid like this, and brings the consequence of underdosage.

An example of the preparation that the pharmaceutical preparation of the above-mentioned type just need be made up before using point.But, beverage, food, domestic and other need use the kind of liquid preparation aspect also have many other type preparations, but ingredient wherein must keep unmixed state before needs use as mentioned above.

The preparation that is used for the feeding baby is an example of these other type preparations.Known many containers can store the component of these preparations, are used for mixing when needs subsequently.

For example, U.S. Pat 5,419,445 have described a kind of baby bottle, and it has two compartments that are used to store Powdered baby preparation and water.Water is stored in bottle portion and powderous preparations is stored in the cartridge assembly.The milk nozzle assembly is positioned at an end of cartridge assembly, and the other end of this cartridge assembly is arranged in a bottle portion.Sealing member and can discharge the sealing part by rotation milk nozzle assembly between cartridge assembly and bottle portion.Activated mixed process makes sealing member outward winding from cartridge assembly by rotation milk nozzle assembly, causes powderous preparations and sealing member to discharge in the water inlet.When shaking bottle, the sealing member after the release is as the instrument of mixed-powder and water.

The rotation of milk nozzle assembly causes isolating interior compartment fusion to obtain littler container in activation process.Therefore, this feature limits in the preactivate bottle available storage area amount.

This bottle can be used to form the preparation that is different from the Infants'feeding product.But, in fact, when activating, sealing member is discharged in the bottle and can generation has the problem of more viscous preparation, because sealing member may stop up two spaces between the compartment, thereby cause preparation not exclusively to mix.

An object of the present invention is to overcome the problem of the above-mentioned type container.

Summary of the invention

Therefore, the invention provides the container that is used to form formulation in liquid form, described container comprises the elongation shell body that is divided into several parts along its longitudinal axis, the inner cavity chamber that is divided into two or more compartments, sealing member and sealing member is remained on the device of release position movably, described sealing member moves to the release position from the detent position that seals all compartments during use, wherein all compartments all do not have sealed and all the elements thing wherein freely mixes in inner cavity chamber and forms preparation when the release position, described sealing member can move to the release position with respect to its other partial rotation from detent position by a part that makes shell body, thereby after compartment is disengaged sealing the volume of inner cavity chamber is remained unchanged.

Advantage with container of the sealing member that can be retained in the release position is that behind depressurization, the mixing of component can not be subjected to the obstruction of sealing member in the inner cavity chamber.If sealing member can move freely in inner cavity chamber after depressurization, then it may partially or completely block the transfer of component between compartment in the inner cavity chamber.

Avoid the potential blocking action of the sealing member that discharged to mean that the component in the inner cavity chamber can fully mix, and can shift blending ingredients from container when needed.

Inner cavity chamber's volume according to container of the present invention remains unchanged behind the compartment depressurization, and its advantage is can obtain being used for the volume of mixer component.

Can be used to make the component of liquid preparation before needs use, to keep activity or steady statue according to container of the present invention, thereby the storage life that prolongs them provide a kind of convenient in use and feasible preparation device for formulating simultaneously.

The present invention mainly by describing with reference to medicine or other liquid preparation that can drink form immediately, for the purpose of concentrated and convenient, hereinafter all uses pharmaceutical preparation as an illustration at this.

Therefore, from container of the present invention administration can drink the difficult problem that pharmaceutical preparation has overcome above-mentioned conventional peroral dosage form immediately, overcome the difficult problem that active component not exclusively maybe can't discharge in the locking device of the above-mentioned type simultaneously.

Described container allows the pharmaceutical preparation " disposable " of required dosage is delivered medicine to the patient.And because the form of active component in the preparation, preparation can directly absorb or postpone the effect starting point of active component, and this is because preparation can contact with gastrointestinal top with mouth immediately.Therefore, absorption can by the vestibule of mouth wall, arrive in throat and the esophagus, rather than begin under one's belt from the Sublingual.Can guarantee the active component of accurate dosage is delivered to the patient from the preparation of container administration of the present invention.

According to first embodiment of the present invention, described shell body is a plain cylindrical form, and is divided into two common cylinder body portions usually, and these two parts are docking together and relatively move between the two allowing.

Herein, butt joint means two parts with the combination of cylinder opposing end surface ways of connecting, and rotates to move between these two butt joint cylinders and carry out.

Preferably, described two parts link together by snap fit.

Further preferably, sealing member is circular spacer, and when detent position, and the threaded area by periphery is connected on the female thread on surface of one of described part, thereby the rotation of one part makes the sealing member thread surface of outwarding winding, and arrives the release position from the closed position.

But, be understandable that container of the present invention can have a lot of different shapes according to its instructions for use.And this container can have aesthetic features or to the special user colony attractive feature of child for example.

According to second embodiment of the invention, sealing member is installed in an end of elongation connector, wherein extend first compartment that connector can be positioned at inner cavity chamber, have preparation on the end of elongation connector away from sealing member, this elongation connector can match with the supplementing structure on the shell body that the covers compartment inner surface partly.

Preferably, shell body is general cylindrical and is separated into two general column parts, first has opening at the one end, when storing, opening is sealed by the screw thread enclosed construction by second portion, in use, sealing member moves to the release position by the sealing motion of separating of enclosed construction.

The advantage of this device just is to separate the strength that the sealing motion does not need user to cost a lot of money, because it only needs enclosed construction is turned on.

Further preferably, opening is positioned at the neck type part of first, described neck type partly has the screw thread that is positioned on the outer surface, be used to guarantee the threaded engagement on enclosed construction and the inner surface, female thread combines with the threaded portion of the elongation connector other end, the sealing motion of separating of enclosed construction makes shell body outward winding from neck type part like this, makes sealing member move to the release position then.

According to third embodiment of the invention, first compartment of inner cavity chamber all has the generally cylindrical of opening for each end, elongation connector in wherein can settling, and opening is fit to sealing member is installed in its closed position, and the other end is fit to prolate body is linked together away from the supplementing structure on the inner surface of an end of sealing member and the shell body part that covers described first compartment.

An advantage of this device is that shell body can rotate, subsequently by holding shell body and sealing member is moved to the release position in its any appropriate location.This rotatablely moving of shell body is converted by structure on the elongation connector and the supplementing structure on the shell body, moves with the sealing of separating that sealing member is provided.

Another advantage of this device is, it allows user to hold shell, so that it rotates with respect to interior compartment, compartment is separated sealing and allowed active component to mix mutually with certain amount of fluid in so just making, and avoids the too early danger of leakage from container of liquid simultaneously.

Preferably, the shell body part is fixed on the interior compartment by the loop seal band.

Further preferably, shell body part and loop seal band can be along direction rotations, described rotation causes the displacement of sealing member, and the trial of rotational shell body portion causes shell to leave Sealing strap in the opposite direction, thereby allows the shell body part to remove from container.

This device allows user after component is mixed shell to be removed from container.

Suitable is, first compartment that an end can be mounted with sealing member is connected on other shell body part, and described other shell body partly has and is positioned at one of them or more other compartment.

Preferably, when other shell body part only had a compartment that is positioned at wherein, sealing member can move into this compartment to arrive the release position.

Further preferably, in use, the rotation of shell body part causes first compartment with respect to the corresponding rotation of other shell body part, and the elongation housing moves along the corresponding inclination extension on the inner surface of first compartment away from the sloping edge of the end of sealing member, causes extending housing and moves and make sealing member move to the release position along the longitudinal axis of container.

Suitable is that at place, described release position, the supplementing structure on structure on the elongation connector and the shell body part irreversibly breaks away from.

According to four embodiment of the invention, when other shell body partly had the compartment of surpassing, sealing member can leave from these compartments and move to the release position.

An advantage of this container is, can preserve those respectively and in a single day mix and will lose active active component, when needs are formed preparation.

Preferably, a compartment is suitable for depositing certain amount of fluid and this compartment or each other compartment and all is suitable for depositing a certain amount of active component.

As described below, if desired, the form that active component can keep dry before mixing or be liquid form.

Liquid can be the liquid of any required use, for example solvent or organic chemicals.Because those preparations that will in use consume or draw, liquid is aqueous or aqueous medium normally.

Therefore, in one embodiment, liquid is a kind of aqueous medium.

Aqueous medium can be water or be made up of water basically.

If desired, active component can comprise the mixture of active component.

Established liquid preparation comprise in the solution or as the active component of its dispersion.

According to an embodiment, active component is solvable in water.

According to alternative embodiment, active component is soluble in water.

Container must often rock usually or otherwise stir, so that especially before using, active component is dispersed in the aqueous medium, particularly under the situation of insoluble active component.

As mentioned above, container can have various ways or shape, comprises bottle, tank body, box body, wide-mouth bottle, medicated bag, utricule or staving.

For example, the medicated bag of adequate types is a kind of paper tinsel bag of selling with trade mark GUALA.

For ready-to-drink preparation, the volume that container is suitable is 40-100ml, but the final volume of pharmaceutical preparation will be no more than 100ml usually, to guarantee to absorb the active component of required dosage.

But as mentioned below, the vessel volume that is used for other purposes can be very big.

A series of materials can be used to prepare container of the present invention.But, usually this container is prepared by plastic material, more specifically be for example high density polyethylene (HDPE) (HDPE), polyethylene (PE), low density polyethylene (LDPE) (LDPE) or polyethylene terephthalate (PET) of thermoplastic, especially for aqueous or water fluid.

But, when container also can be used for forming the material that comprises organic solvent and oil product, can use other can the material that it comprised be tolerated or inert plastic material.

In addition, if container is a tank body, the material that then is used to form tank body can be aluminum, stannum, steel or above-mentioned plastic material.

Preferably, container is equipped with the locking device of conventional obvious stopper, is at the container that leaves factory or manufactured place or be not opened or changed before administration or use with what guarantee to offer the user.

Because the character of active component, require usually for container according to the present invention provides locking device to children's safety, though, will suppose that in fact the consciousness of consumer is administration from container according to the present invention in the preparation use usually by father and mother's control.

Active component is spaced from each other with not combining form and aqueous medium and is kept in the container, when preparing to use preparation till.

Therefore, said here non-combination is meant waterborne liquid and active component no matter the state when which kind of form to keep them to be introduced into container with moves to the release position up to sealing member, forms preparation thereby cause.

According to an embodiment, active component is a powder type.

In a preferred embodiment, powder particle is a micron-scale.

In a further preferred embodiment, granule is a nano-scale.

In another embodiment, a compartment can also be deposited a kind of active component before mixing.

Start the preparation that container of the present invention forms and to be delivered to people or non-human animal by separating sealed partition.

Therefore, in one embodiment, preparation is suitable for oral delivery.

Therefore, this aspect according to the present invention, active component is selected from health care water (aquaceutical), nutritional drugs, medicine, alcoholic beverage, non-alcoholic beverage, food, homeopathic therapeutic method's medicament, prebiotics, probiotic bacteria or their mixture.

For example, active component can be a kind of probiotic bacteria, and this probiotic bacteria can provide 100% probiotics preparation at the most be stored to many 3 years with dried forms after.

According to this embodiment, probiotic bacteria is the bacterial strain of probiotic bacteria, and described probiotic bacteria is selected from lactobacillus, bacillus bifidus, streptococcus faecalis and streptococcus thermophilus, enterococcus and solidifies bacillus cereus.

Suitable probiotic bacteria example is: bacillus acidophilus, imunitass lactobacillus casei, Lactobacillus bulgaricus, lactobacillus helveticus, Mus A lactobacillus, salivarium lactobacillus, Lactobacillusreuteri, lactobacillus casei, Lactobacillus brevis, Lactobacillus plantarum, Mus B lactobacillus, lactobacillus lactis: bifidobacterium bifidum, bifidobacterium infantis, lactic acid Bacillus bifidus, bifidobacterium longum, bifidobacterium breve; Excrement ball chain bacterium, streptococcus thermophilus; Enterococcus and bacillus coagulans.

Therefore, described preparation can be a kind of lactic acid type beverage that comprises the conventional probiotic products of the above-mentioned type, and this preparation only is adapted at storing about 21 days under the refrigerated condition usually.This product only comprises its original activity of about 1% when being everlasting consumption.

Particularly preferred probiotic bacteria has anti-cholesterolemia activity.

Container also comprises prebiotics except that probiotic bacteria.

The prebiotics that uses among the present invention normally can't digest in small intestinal and enter the nutrient material of large intestine as the probiotic bacteria nutrient source then.

The example of suitable prebiotics is selected from glucide, inulin base prebiotics material, Bulbus Allii and extract, Mel and extract thereof and dietary fiber, and described glucide comprises that monosaccharide, disaccharide, monomeric unit are selected from the oligosaccharide and/or the polysaccharide of fructose, galactose, glucose and maltose.

Therefore, this type of suitable material is lactose, sucrose, dextrin, cellulose, glycogen and starch.

The prebiotics material of many fruit or vegetable or plant is applicable to described prebiotics.

Therefore, other suitable prebiotics comprises and derives from chickory inulin base prebiotics, Jerusalem artichoke or Herba Taraxaci, Bulbus Allii or Bulbus Allii extract.Other suitable prebiotics is Mel or its extract and common dietary fiber.

According to a preferred embodiment of the invention, said preparation does not contain lipid material.

Therefore, the present invention suitable probiotic products is no fat, so right and wrong are based on milk product.

Preparation in container of the present invention is used for oral delivery and a kind of or every kind of active component is the powder particle form, particularly when described active component be that described powder particle is the particle form that allows active component controlled release in gastrointestinal tract when having treatment or the medicine of preventive effect or other preparation.

Active component is capsule, granule, liquor, powder or tablet form normally.

When active component was powder form, preferred powder particle was the particle form that allows active component controlled release in gastrointestinal tract.

More preferably, this granule has different release profiles.

Described active component can discharge with controlled and predetermined way from granule in gastrointestinal tract, and multiple this type of granule can be used for preparation of the present invention, and these granules also are that those skilled in the art of the present technique are known.

In order to ensure the controlled release of active component, preferably on granule with one or more polymeric material coatings to realize described controlled release.

As mentioned above, granule can be micron-sized or littler size, and is promptly nano level, writes in the text and does " nanonised ".

In one aspect of the invention, active component is a large amount of granules or granose form, and each granule comprises the nuclear of active component or its pharmaceutically acceptable salt, and wraps by the polymer coating of this nuclear to reach the release profiles of expectation.

Before the using polymer coating, can use sealant or barrier layer to described nuclear.

Suitable sealant or blocking agent are permeable or solvable reagent, for example hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose and xanthan gum.

Can add other additive to improve the processing characteristics on sealant or barrier layer.Described reagent can comprise Talcum, glue Silicon stone, polyvinyl alcohol, titanium dioxide, particle silicon, fumed silica, glyceryl monostearate, magnesium trisilicate or magnesium silicate or its mixture.

Sealant and barrier layer can use the known technology in present technique field from solvent coating.

Suitable is active component to be applied to inert core, for example average diameter 0.4-1.1mm, the more preferably top grade seed of 0.85-1.00mm.

Active component can with or be not applied on the inert core together with other excipient.Active component for example can use the fluidized bed coating device or be coated with in the system at dish and spray from solution or suspension.In addition, can be adhered to pulverous active component on the inert core by using binding agent.Nuclear also can be by examining with following suitable plasticizers and other required processing aid extrusion molding.

Can use polymer widely in the polymer coating.The example of these polymer comprises the polymer coating material, for example cellulose acetate phthalate, maleic acid cellulose acetate, phthalic acid hydroxypropyl methylcellulose, phthalic acid polyvinyl acetate, Eudragit ^Polyacrylic acid and polyacrylate and methacrylate coating, for example Eudragit ^S or Eudragit ^L, polyvinyl acetal lignocaine acetate, acetic acid succinic acid hydroxypropyl methylcellulose, benzenetricarboxylic acid cellulose acetate, lac; Hydrogel and gel formation material, for example for example hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, crosslinked starch, microcrystalline Cellulose, chitin, cellulose propionate cellulose acetate, propanoic acid acetate fiber, cellulose acetate butyrate, cellulose triacetate, aminoacyl-methacrylate copolymer (Eudragit of CVP Carbopol ETD2050, sodium alginate, carmellose sodium, Carmellose calcium, carboxymethyl starch sodium, polyvinyl alcohol, hydroxyethyl-cellulose, methylcellulose, gelatin, starch and cellulose base cross linked polymer ^RS-PM, Rohm﹠amp; Haas), amylase, collagen, casein, agar, arabic gum, sodium carboxymethyl cellulose, carboxymethylethylcellulose, (inflatable water absorbent polymer) gathers (hydroxy alkyl methacrylate) (m.wt is about 5k-5000k), polyvinylpyrrolidone (m.wt is about 10k-360k), anion or cationic water gel, the polyvinyl alcohol of low acetic acid residue, the inflatable mixture of agar and carboxymethyl cellulose, maleic anhydride and styrene, ethylene, the copolymer of propylene or isobutene., pectin (m.wt is about 30k-300k), polysaccharide is agar for example, arabic gum, karaya, tragacanth, Algin and melon glue, polysaccharide, Polyox ^Polyoxyethylene (m.wt is about 100k-5000k), AquaKeep ^Acrylate copolymer, glucosan diester, the pure and mild poly N-ethylene-2-Pyrrolidone of crosslinked polyethylene, starch glucose ester sodium are (as Explotab ^Edward Mandell C.Ltd); Water absorbent polymer for example polysaccharide, methylcellulose, carboxymethylcellulose calcium, carboxylic propyl methocel, carboxy-propyl cellulose, hydroxy methocel, celluloid, carboxymethyl cellulose, cellulose ether, polyethylene three phthalic acids, polyvinyl isobutyl ether, polyester, polyoxyethylene (as Polyox ^, Union Carbide), methylethylcellulose, ethyl carboxy ethyl cellulose, cellulose acetate, ethyl cellulose, cellulose butyrate, cellulose propionate, gelatin, collagen, starch, maltodextrin, amylase, polyvinylpyrrolidone, polyvinyl alcohol, polyvinyl acetate, fatty glyceride, polyacrylamide, polyacrylic acid, amino methyl acrylate copolymer Eudragit for example ^RL or Eudragit ^RS (Eudragit for example ^, Rohm and Haas), other acrylic acid derivative, Isosorbide Dinitrate, polydimethylsiloxane, natural gum, lecithin, pectin, alginate, alginic acid ammonia, sodium alginate, calcium, potassium, hydroxypropyl alginate, agar, natural gum: arabic gum, karaya, Sophora japonica L. glue, tragacanth, carrageenin, melon glue, xanthan gum, scleroglucan and their mixture and blend.

In one embodiment, polymer coating comprises a kind of film forming polymer of the insoluble thin film of the acceptable formation hypotonicity of pharmacy of larger proportion.

In another embodiment, polymer coating comprises the film forming polymer of the insoluble thin film of the acceptable formation high osmosis of a kind of pharmacy than small scale.

Further preferably, this or every kind of polymer is a methacrylic acid copolymer.

Scheme as an alternative, this or every kind of polymer is the amino methyl acrylate copolymer.

But, also can use the mixture of methacrylate copolymer and amino methyl acrylate copolymer.

Comprise by Rohm﹠amp; The trade mark that Haas sells is that the methacrylic acid copolymer of the polymer of Eudragit S and Eudragit L is applicable to preparation of the present invention.

Comprise by Rohm﹠amp; The trade mark that Haas sells is that the amino methyl acrylate copolymer of the polymer of Eudragit RS and Eudragit RL is applicable to preparation of the present invention.

The independent coating that this polymer of two types also can be used for examining with any mixed.

Except above-mentioned Eudragit polymer, many these polymer can be used to cause that release lags behind.These polymer comprise methacrylate copolymer (for example Eudragit NE 30D).

The out of Memory of Eudragit polymer can " obtain on the edited by JamesMcGinity (Marcel Dekker Inc., NewYork) pg 109-114) from Chemistry and Application Properties ofPolymethacrylate Coating Systems " from " Aqueous Polymeric Coatings forPharmaceutical Dosage Forms.

Polymer coating can comprise that one or more soluble excipient are to increase the permeability of coating.

Suitable is that this or every kind of solvable excipient of use is selected from soluble polymer, surfactant, alkali metal salt, organic acid, sugar and sugar alcohol.

The example of solvable excipient comprises for example sodium lauryl sulphate, organic acid acetic acid, adipic acid, citric acid, fumaric acid, 1,3-propanedicarboxylic acid, malic acid, succinic acid and tartaric acid and sugar for example lactose, maltose alcohol, mannitol, sorbitol and xylitol, xanthan gum, dextrin, poloxamer and maltodextrin of glucose, fructose, dextrose and sucrose and sugar alcohol for example for example of polyvinylpyrrolidone, polyvinyl alcohol, sodium chloride, surfactant.

Polymer coating also comprises one or more adjuvant, and it is selected from filler, plasticizer and defoamer.

Typical filler comprises Talcum, aerosil, glyceryl monostearate, magnesium stearate, calcium stearate, Kaolin, silica sol, Gypsum Fibrosum, micron silica and magnesium trisilicate.

With the polymer gross dry weight is benchmark, and the amount of filler can reach about 300% at the most.

Coating can also comprise a kind of material that improves Polymer Processing.This material so-called " plasticizer " comprises for example adipate ester, azelate, benzoate, citrate, isoebucate, phthalic acid ester, sebacate, stearate and ethylene glycol.

Representational plasticizer comprises the acetylation monoglyceride; Butyl phthalyl glycolic butyl ester; Dibutyl tartrate; Diethyl phthalate; Dimethyl phthalate; Ethyl phthalyl glycolic ethyl ester; Glycerol; Ethylene glycol, glycerol; The triacetic acid citric acid glyceride; Glyceryl triacetate; Three propargyl alcohols (tripropinoin); Diacetine; Dibutyl phthalate; Acetylated monoglyceride; Polyvinyl alcohol; Oleum Ricini; Triethyl citrate; Polyhydric alcohol, acetate, glyceryl triacetate, acetyl triethyl citrate, dibenzyl phthalate; Dihexylphthalate, butyl octyl phthalate, diisononyl phthalate, butyl octyl phthalate, dioctyl azelate, epoxy aliphatic ester, three benzenetricarboxylic acids, three different monooctyl esters, phthalic acid two b hexyls, dinoctyl phthalate, diisooctyl phthalate, diisooctyl phthalate, 2-nonyl-phthalate ester, phthalic acid two n-tridecane base esters, three benzenetricarboxylic acids, three-2-b hexyl, adipic acid two-2-b hexyl, decanedioic acid two-2-b hexyl, Azelaic Acid two-2-b hexyl, dibutyl sebacate, single caprylin and glycerol decanoin.

Based on the weight of dry polymer, the amount that is used in the plasticizer in the coating is approximately 10% to 50%.

Be used to form granose coating amount and can send character and release profiles decides, comprise the amount of delivering drugs, needed time delay and granose size by needed.

Sealant or barrier layer can be applied to this polymer coating.

Here the above-mentioned specific sealant that is used to examine or any materials on barrier layer can be used in sealant of Chu Xianing or barrier layer.

When active component is particle form, comprise in the granule a certain proportion of can be when preparation be drawn the granule of rapid release active component.

The preparation that is used for oral administration generally includes one or more excipient, and this excipient is selected from absorption enhancer, acid regulator, antioxidant, foaming agent, flavoring agent, fusion inhibitor, pH regulator agent, antiseptic, solubilizing agent, sweeting agent and sense of taste masking agent.

The example of these excipient has explanation hereinafter.But,, also can use other excipient well known in the art if be fit to.

Can select these excipient to prolong the storage life of product, 36 months storage life will become possibility.

The example of suitable absorption enhancer comprises: acetone, ethanol, ascorbic acid, bile salts, chitosan, citric acid, cyclodextrin, dimethyl sulfoxide, isopropyl myristate, oleic acid, polidocanol (Laureth 9), polyvinyl alcohol, propylene glycol and sodium lauryl sulphate.

The example of suitable acid regulator comprises: fumaric acid, lactic acid, sodium phosphate (binary with monobasic) and tartaric acid.

Suitable examples of antioxidants comprises: alpha tocopherol, ascorbic acid, BHA, butylated hydroxytoluene, fumaric acid, malic acid, Propylgallate, sodium ascorbate, sodium pyrosulfite, sodium sulfite and stearic acid.

The example of suitable foaming agent comprises: citric acid and sodium bicarbonate and/or potassium bicarbonate.But can use aforesaid other foaming agent well-known in the art equally.

The example of suitable flavoring agent comprises flavoring agent of fruit.

Flavoring agent can be a fruity arbitrarily, and for example Fructus Mali pumilae, Fructus Musae, blackberry, Pericarpium Citri tangerinae, Fructus Citri junoris, Fructus Persicae, raspberry or Fructus Fragariae Ananssae are to help to cover the special unwelcome taste that is caused by active component or excipient.

Also can use medical herbs and other flavoring agent, for example menthol, Herba Menthae, Oleum menthae or Rhizoma et radix valerianae.Also can use the compositions of these flavoring agents and flavoring agent of fruit, for example orange and peach or orange and Herba Menthae.

The example of suitable pH regulator agent comprises: malic acid, potassium citrate, sodium citrate and sodium phosphate (binary and monobasic).

Suitable examples of preservatives comprises: two DMC dimethyl carbonate, glycerol, methyl hydroxybenzoate, potassium sorbate, propyl p-hydroxybenzoate, sodium benzoate, sodium pyrosulfite and sodium sulfite, benzalkonium chloride, sodium propionate and sorbic acid.

The example of suitable solubilizing agent comprises: the pH regulator agent of ethanol, inorganic solvent, organic solvent, buffer agent form, poloxamer (poloxamer) and surfactant.

Suitable poloxamer is the poloxamer polyhydric alcohol.

The poloxamer polyhydric alcohol is a series of block copolymer relevant with oxirane and expoxy propane.

More specifically, the poloxamer polyhydric alcohol is alpha-hydro-omega-hydroxypoly oxirane poly(propylene oxide) polyethylene oxide block copolymer, more particularly polyethylene-propylene glycol copolymers or poly(ethylene oxide)-poly(propylene oxide) copolymer.

The content of the poly(ethylene oxide) part in the preferred poloxamer is between 60%-90%, more preferably between 70%-80%.

The commodity of the example of these poloxamers are called Lutrol, Monolan and Pluronic.

During use, poloxamer is melted, then active component and other adjuvant are dispersed in the poloxamer of fusing.

Poloxamer described in the literary composition also comprises the combination of two or more poloxamers.

Surfactant comprises: anion, cation, natural and non-ionic surface active agent.

The example of suitable sweeting agent comprises: synthetical and natural sweeting agent.The artificial sweetener that the present invention uses is preferably selected from aspartame and acesulfame potassium or their mixture, but also can use for example glucide of other artificial sweetener.Natural sweetener comprises fructose and sucrose.

The example of suitable sense of taste masking agent comprises: acesulfame potassium, alginic acid, alpha-glucan, aspartame, glucose, ethyl maltol, ethyl vanillin, fumaric acid, fructose, glycerol, lactose, malic acid, maltose alcohol, maltol, maltose, menthol, pectin, glucide, sorbitol, sucrose, starch and starch derivatives, tartaric acid and vanillin.

Be understandable that, be used for to overlap between the excipient of various objectives.

Preferred liquid comprises antiseptic, although liquid also can use Pasteur's method sterilization as required.If desired, liquid also can comprise other composition, for example sweeting agent.

When container is prepared by plastic material,, use is called the technology of flash pasteurization or heat perfusion pasteurization if use Pasteur's method sterilization.

Flash pasteurization need be warmed up to liquid more than 65 ℃ in very short time before perfusion, reduced to about 30-40 ℃ then again immediately.Plastic bottle body can make in this way.But, make in this way, between quick sterilization and perfusion point, there is the danger of liquid contamination.Therefore, the antiseptic of common this method and type mentioned above is united use.

Heat is filled sterilization, as described in name, comprises liquid is warmed up to keeping this temperature more than 65 ℃ and dabbling the time.Therefore, this method is suitable for the plastic bottle body of glass and special heatproof, for example PET.

According to the present invention, can prepare the combination of a lot of active component or active component.The concrete active component of quoting in the literary composition also comprises the acceptable salt of its pharmacy, alkali, hydras and other form.

Medicine in the literary composition also means homoeopathic reagent and is used to select the medicament of administration.

Suitable medicine is selected from adrenaline excitant, adrenergic blocker, adrenocortical hormone, the smoking cessation agent, anobolite, analgesic, androgen, antacid, antiabnormal reaction agent, anti-asthmatic agent, antibiotic, anticarcinogen, antidepressants, antidiabetic, anti-diarrhea agents, antidote, antiemetic, Anti-epileptics, the gout agent, antihistaminic, antihypertensive, the antihypercholesterolemic medicine, anti-infective, antimigraine, appetrol, the osteoporosis agent, antianxiety drugs, blood modifier, bronchodilator, cardiovascular agents, contraceptive, cytokine, dietary supplement, fertility factor, the intestines and stomach agent, hormones, sleeping pill, laxative, local anesthetic, lymphokine, mineral, mucolytic agent, anesthetics, non-steroidal anti-inflammatory agent, the psychosis agent, steroid, vaccine and vitamin.

Suitable epinephrine agonist or selectivity β 2 agonists comprise: the pure and mild terbutaline of husky fourth ammonium.

Suitable adrenergic blocker or α/Beta receptor blockers comprise: Carvedilol, metoprolol and Propranolol.

Suitable adrenocortical hormone comprises: betamethasone; Corticosterone; Cortisone; Fluocinolone acetonide; Fluprednisolone; Fluticasone propionate; Hydrocortisone; Methylprednisolone; Mometasone; Paramethasone; Andrographolide; Prednisone; And triamcinolone.

Suitable smoking cessation agent comprises, especially nicotine.

Suitable tissue metabolism's agent comprises: the compound preparation of spironolactone and hydrochlorothiazide and spironolactone.

Suitable analgesic comprises: acetaminophen, aspirin (aspirin), alfentanil, benorylate; buprenorphine; Butorphanol; Choline magnesium trisalicylate; codeine; salt acidify diamorphine; Diflonid; dihydrocodeine phosphate; fentanyl; dihydrocodeinone; Dromoran; meptazinol; methadone hydrochloride; morphine; nalbuphlne hydrochloride; nefopam hydrochloride; oxycodone hydrochloride; pentazocine; pethidine hydrochloride; penicillin; phenazocine hydrobromide; phenazopyridine hydrochloride; hydrochloric acid phenoperidine; sodium salicylate; sufentanil citrate and tramadol hydrochloride.

Suitable androgen comprises: testosterone and danazol.

Suitable the intestines and stomach agent comprises antacid, diarrhea and antiemetic, and comprises: calcium hydroxide, calcium carbonate, cimetidine, famotidine, Lansoprazole, magnesium hydroxide, magnesium trisilicate, omeprazole, draw beta to draw azoles, ranitidine, sodium bicarbonate, hydrochloric acid Luo Pu Lamine, hydrochloric acid diphenoxylate, zaldaride, difenidol hydrochloride, domperidone, metoclopramide and Ondansetron Hydrochloride.

Suitable antiabnormal reaction agent comprises: astemizole, azatadine maleate, hydrochloric acid bromo diphenylamines, brompheniramine maleate, carbinoxamine maleate, cetirizine hydrochloride, chlorphenamine maleate, tavehil, marezine, cyproheptadine hydrochloride, Dimethindene Maleate, benadryl, diphenylpyraline hydrochloride, doxylamine succinate, fexofenadine hydrochloride, loratadine, the mebhydrolin, trimeton, phenyltoloxamine citrate, terfenadine, tripelennamine and triprolidine hydrochloride.

Suitable anti-asthmatic agent and bronchodilator comprise aminophylline, Clenbuterol Hydrochloride, ketotifen, orciprenaline, albuterol, terbutaline sulfate, Oxtriphylline and beclometasone.

Suitable antibiotic comprises: amoxicillin, ampicillin, Azithromycin, Bacampicillin Hydrochloride, carbapen, cefaclor, cefadroxil, cefuroxime, cephalexine, chloromycetin, ciprofloxacin, Clarith, Clindamycin Hydrochloride, cloxacillin, Abboticine, lincomycin hydrochloride, metampicilline, mupirocin, neomycin, norfloxacin, ofloxacin, rifampicin and Ticarcillin Disodium.Suitable anticarcinogen comprises: Bleomycin Sulphate, busulfan, carboplatin, chlorambucil, cis-dichlorodiammineplatinum, cyclophosphamide, mercaptopurine, L-PAM, methotrexate, mitotane, procarbazine hydrochloride and Tamoxifen Citrate.

Suitable anti-gallbladder alcohol blood agent comprises: phytosterol, beta Sitosterol, campesterol (campsterol), stigmasterol, brassicasterol, and situstanol.

Suitable antidepressants comprise: amitriptyline, Amoxapine, bupropion hydrochloride, desipramine, fluoxetine Hydrochloride, fluvoxamine maleate, miboplatin are bright, lithium carbonate, maprotiline, Mianserin Hydrochloride, Moclobemide, nomifensine maleate, hydrochloric acid Paroxetine, sertraline hydrochloride, trazodone hydrochloride, trimeprimine and VENLAFAXINE HCL.

Suitable antidiabetic comprises: Acarbose, chlorpropamide, glimepiride, glipizide, insulin, metformin hydrochloride, tolazamide, tolbutamide and troglitazone.

Suitable antuepileptic comprises: carbamazepine, lamotrigine and phenytoin Sodium.

Suitable gout agent comprises: allopurinol, colchicine and sulphinpyrazone.

Suitable antihypertensive comprises: M B 17803A, alprenolol, amiloride hydrochloride, Amlodipine Besylate, atenolol, methyclothiazide, betaxolol hydrochloride, the bisoprolol fumarate, Bupranolol Hydrochloride, captopril, carvedilol, chlorothiazide, chlortalidone, clonidine hydrochloride, diltiazem hydrochloride, Carclura, Enalapril, fosinopril sodium, Guanabenz Acetate, guanadrel sulfate, guanethidine monosulphate, Guanfacine Hydrochloride, hydrochlorothiazide, indamines, Isradipine, lisinopril, Losartan, mefruside, methyldopa, methaqualone, Metoprolol Tartrate, moexipril hydrochloride, nadolol, Licardipine Hydrochloride, nifedipine, oxprenolol, pindolol, many thiazines, prazosin, propranolol hydrochloride, quinapril hydrochloride, quinethazone, ramipril, terazosin hydrochloride, timolol maleate, triamterene, DU-717, valsartan, hydralazine hydrochloride, minoxidil, phentolamin methanesulfonate and terazosin hydrochloride.

Suitable anti-infective comprises: domiphen bromide, aminosallcylic acid, cinoxacin, dapsone, dicloxacillin, Hetabiotic, isoniazid, lomefloxacin hydrochloride, Lorabid, sodium nafcillin, nalidixan, nitrofurantoin, oxacillin sodium, pyrazinamide, renoquid, sulfamethoxazole, Itraconazole, tobramycin, trimethoprim, Nitric acid butoconazole, clotrimazole, fluconazol, griseofulvin, ketoconazole, miconazole, nysfungin, terbinafine HCl, terconzaole, tioconazole, tineatonsurans is moved back, chloroquine (antimalarial), Mefloquine Hydrochloride, quinine, ivermectin (antiparasitic), piperazine, pyrvinium pamoate, thiabendazole, aciclovir, Ganciclovir Sodium, interferon, valaciclovir hydrochlordide, and azidothymidine AZT.

Suitable antimigraine comprises: dihydroergotamine, Ergotamine, desernil, pizotifen and Sumatriptan Succinate.

Suitable appetrol comprise: sibutramine and α, Ionamin.

Suitable antianxiety drug comprises: alprazolam, buspirone hydrochloride, bent, chlorine nitrogen grass, lorazepam, meprobamate, oxazepam and prochlorperazine.

Suitable blood vessel modifier comprises anticoagulant, anti-platelet agents, folic acid derivatives and their compositions; Ferrum and iron ion comprise liver extract preparation and comprise its preparation; Hemorheology preparation and hemorrhage.

Suitable contraceptive comprises: ethinylestradiol, norgestimate, desogestrel, lynenol, norgestrel, Amen and ethisterone.

Suitable cytokine comprises interleukin 8, erythropoietin and interleukin 8-2.

Suitable hormones comprises: diethylstilbestrol, Fei Nasi carry, Cynomel, levothyroxine sodium and calitriol.

Suitable local anesthetic comprises: bupivacaine hydrochloride, lignocaine (lignocaine) and L-67.

Suitable laxative is a dantron.

Suitable non-steroidal anti-inflammatory agent (NSAIDs) comprising: acemetacin, azapropazone, diclofenac, etodolac, fenbufen, fenoprofen calcium, flurbirprofen, ibuprofen, indomethacin, ketone ibuprofen, ketorolac, Meclofenamate Sodium, mefenamic acid, naproxen, Evil promazine, crovaril, Phenylbutazone, piroxicam, sulindac, tenoxicam, Artiflam, meclofenamic acid and tolmetin sodium.

Suitable vitamins and food additives comprise: ascorbic acid, carotene (vitamin A precursor), niacin, pantothenic acid, pyrodoxine, retinol, lactoflavine, sodium chloride (source of sodium ion), sodium fluoride (oral hygiene/bone density), sodium phosphate (hypophosphatemia), thiamine, vitamin A, vitamin B12, vitamin C, vitamin D, vitamin E and vitamin K.

Container of the present invention has many application and purposes.

Therefore, except the application of the preparation that is used to form human body and animal oral administration, this container can also be used to form the preparation by other administration.For example, this container can be used for the administration of nasal decongestant and bronchodilator, and it can be used as an inhaler like this.Other suitable applications comprises to be formed the eye medicament and sends skin and mucus membrane.

Container of the present invention also can be as forming injection, and sterile product can mix in container before administration.The concrete application of this respect is in the vaccine field.

Be understandable that container of the present invention has special application in old and child's administration.

Container of the present invention also can be as the assembly in urgent health care and the first-aid unit.Therefore, except above-described embodiment, this container can be included in synthetic disinfectant and analgesic before the patient in the accident of being administered into.Another example is, comprises the container of the component that is used to handle burn.

When container of the present invention is used to form food, this based food generally includes oil, soup, soy sauce, flavoring agent, cereals, comprise breakfast fast food, baby food and baby preparation, food and drink, fruits and vegetables, still more frequent is food supply place that is used for family, dining room and " dashboard " or fast food restaurant.

Be understandable that the present invention has special application for babymilk or preparation, wherein solid is stored in the compartment and before using and mixes with water.This aspect of the present invention has special benefits, because user does not need to provide the water supply of cleaning.

The example of non-alcoholic beverage comprises that tea bag draws together green tea and medicated tea, coffee, chocolate beverage, milk, energy drink, combined beverage and edible beverage.

Combined beverage an example be to comprise the beverage that surpasses a kind of composition, for example a kind of mineral and a kind of vitamin.

Except various alcoholic beverage, container of the present invention also can prepare the preparation that is used for the treatment of excessive drinking.

Clearly if desired, in all above-mentioned embodiments, the composition that is used for oral administration will be sterilized/the pasteurization sterilization.

According to another embodiment of the invention, preparation is made into local delivery.

Therefore, this container can be used to send hair dye.

The term hair dye that uses in the literary composition comprises permanent and impermanent hair-dyeing agent, highlight agent and beard stain.

The example of the hair dyeing active component that uses in the literary composition is hydrogen peroxide, ammonia, phenylenediamine, resorcinol and dimethyl stearyl chlorination ammonium.

What can form in container of the present invention equally is various types of cosmetics, comprises that two kinds of perfume and the tanning agent in perfume in hands frost, hand lotion, replenisher liquid, food supplement, the container and deodorizer, the container comprises preceding and back daylight or do not have the daylight type.In the latter, the example of tanning agent is Fructus Pruni, Fructus Pruni pseudocerasi.

Container of the present invention can be used for formulation delivered to vagina.

According to this embodiment, preparation is the form of irrigating solution.

Preferred active component is a probiotic bacteria.

Suitable in this probiotic bacteria is with above described consistent.

Preferred, comprise a kind of prebiotics in the container.

At this, the example of suitable prebiotics is exactly those prebioticses that above limit.

As mentioned above, the volume of liquid preparation is less than 100ml usually, especially in the scope of 40-80ml.The component that the size of container will adapt to the administration of liquid preparation and form these preparations comprises and considering when preparation is formed for example because the form that the variation of foaming phenomenon brings and the variation of volume.

If desired, the volume of container and liquid preparation can be increased to 5000ml.Can imagine the situation that needs the 5000ml volume, if for example at the volley the heart someone need distribute the energy drink of significant volume or similar articles the time.For bulk container, need make and with the hands go rotary container to start the Kaifeng instrument.

Described container can be used to form abnormal smells from the patient reinforcing agent, aromatotherapy agent, with fresh air and evaporant, the set of mentioning hereinafter that is called air freshener.

Therefore, according to another embodiment of the invention, this container is used to form air freshener.

Other of container of the present invention used and purposes is cleaning agent and the detergent that synthesizes in family and industrial aspect use.

According to another embodiment, described container is used to form fuel.

Preferred component separately is gasoline and oil.

More preferably, this gasoline and oil are used for two-cycle engine with 40: 1 ratio.

According to another embodiment of the invention, liquid and this or every kind of active component are used for forming the preparation that uses at civil construction or japanning and decoration.

Application in this respect comprises paint, mixture of glass fibers, is used for the material of silicone mold, and so-called " screen wall " promptly is used for the material of building industry, and wherein powder and water are mixed for plastering, more particularly conventional plaster and filler.

The other embodiment of container purposes of the present invention is aspect agricultural and gardening, for example container is used to form fertilizer.

Other purposes of container of the present invention can comprise the field of common rehydrated product.

Implement mode of the present invention

The present invention will further specify in the following embodiments.

The preparation of following embodiment 1-14 preparation carries out at laboratory level, and scalable.When as hereinafter saying detailed description, when in sealed container, preparing, can use those compositions and correlative thereof according to the present invention.

The preparation of embodiment 1-10 is the embodiment of those unstable or undissolved active component in aqueous medium.Embodiment 11 and 12 preparation are the embodiment of stable and soluble active component in aqueous medium.

Embodiment 13 and 14 is used to optimize from container of the present invention carry out the method for preparation administration and the example of test.

Embodiment 1

Aceta Elixir (1000mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/w
			Acetaminophen	1000	59.17％
Ascorbic acid	100	5.92％
			Citric acid	120	7.10％
Sodium bicarbonate	60	3.55％
			Potassium bicarbonate	60	3.55％
Glucose
		20	1.18％
Caffeine
		30	1.78％
Glucide				250	14.79％
	The strawberry-flavoured agent	50	2.96％
Amount to				1690	100％

Take by weighing these compositions and put into the appropriate containers of selling with trade mark SECURIAINER, vibration mixed five minutes then.Checked a container in per two minutes, with all powder on the spatula removal container limit.Check that mixture mixes homogeneous and checks from visual appearance guaranteeing.The sample that takes out product is used for analyzing, and uses HPLC to determine the amount of active component.

The visual appearance of preparation in the same assessment water finds that adularescent is to linen effervescent suspension.

When carrying out the multiple dose test, increase the amount of active component and excipient accordingly.

Embodiment 2

Genprin (500mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Aspirin	500	42.02％
Ascorbic acid	100	8.40％

Citric acid	120	10.08％
			Sodium bicarbonate	60	5.04％
Potassium bicarbonate	60	5.04％
			Glucose
	20	1.68％
			Caffeine
	30	2.52％
			Glucide	250	21.01％
The strawberry-flavoured agent	50	4.20％
			Amount to	1190	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 3

Motrin (200mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			4-isobutyl group-Alpha-Methyl phenylpropionic acid (ibuprofen)	200	23.53％
Citric acid	120	14.12％
			Sodium bicarbonate	60	7.06％
Potassium bicarbonate	60	7.06％
			Cyclodextrin	100	11.76％
Codeine
		10	1.18％
Glucide				250	29.41％
	The strawberry-flavoured agent	50	5.88％
The total amount of one dosage				850	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 4

Diclofenac preparation (100mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Diclofenac sodium	100	15.15％
Citric acid	120	18.18％
			Sodium bicarbonate	60	9.09％
Potassium bicarbonate	60	9.09％
			Cyclodextrin	100	15.15％
Caffeine
		30	4.55％
Glucide
		125	18.94％
Sucrose
		40	6.06％
Flavoring agent
		25	3.79％
Amount to				660	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 5

Amitriptyline preparation (150mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Amitriptyline
	150	25.82％
			Citric acid	120	20.65％
Sodium bicarbonate	60	10.33％

Potassium bicarbonate	60	10.33％
			Benzalkonium chloride	1	0.17％
Sucrose
		40	6.88％
Glucide
		125	21.52％
Flavoring agent
		25	4.30％
Amount to				581	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 6

Amoxapine preparation (150mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Amoxapine
	150	25.82％
			Citric acid	120	20.65％
Sodium bicarbonate	60	10.33％
			Potassium bicarbonate	60	10.33％
Benzalkonium chloride	1	0.17％
			Glucide
	125	21.52％
			Sucrose
	40	6.88％
			Flavoring agent
	25	4.30％
			The total amount of one dosage	581	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 7

Chlorpheniramine (150mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Chlorpheniramine	4	0.92％
Citric acid	120	27.59％
			Sodium bicarbonate	60	13.79％
Potassium bicarbonate	60	13.79％
			Benzalkonium chloride	1	0.23％
Sucrose
		40	9.20％
Glucide
		125	28.74％
Flavoring agent
		25	5.74％
Amount to				435	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 8

Cetirizine (10mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Cetirizine
	10	2.27％
			Citric acid	120	27.21％
Sodium bicarbonate	60	13.61％
			Potassium bicarbonate	60	13.61％
Benzalkonium chloride	1	0.23％
			Sucrose
	40	9.07％
			Glucide
	125	28.34％

Flavoring agent

	25	5.66％
			Amount to	441	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 9

Bisacodyl preparation (10mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Bisacodyl
	10	2.27％
			Citric acid	120	27.21％
Sodium bicarbonate	60	13.61％
			Potassium bicarbonate	60	13.61％
Benzalkonium chloride	1	0.23％
			Glucide
	125	28.34％
			Chocolate flavor
	25	5.66％
			Sucrose
	40	9.07％
			Amount to	441	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 10

Dantron (15mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Dantron
	15	3.36％

Citric acid	120	26.91％
			Sodium bicarbonate	60	13.45％
Potassium bicarbonate	60	13.45％
			Benzalkonium chloride	1	0.22％
Sucrose
		40	8.97％
Glucide
		125	28.03％
The strawberry-flavoured agent				25	5.61％
	The total amount of one dosage	446	100％

Use with embodiment 1 in identical method preparation and test said preparation.

Embodiment 11

Isosorbide mononitrate (20mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Isosorbide mononitrate
	20	4.44％
			Citric acid	120	26.61％
Sodium bicarbonate	60	13.30％
			Potassium bicarbonate	60	13.30％
Benzalkonium chloride	1	0.22％
			Sucrose
	40	8.87％
			Glucide
	125	27.72％
			The strawberry-flavoured agent	25	5.54％
The total amount of one dosage	451	100％

Take by weighing these compositions and put into the appropriate containers that trade mark SECURIAINER sells, vibration mixed five minutes then.Checked a container in per two minutes, with all powder on the spatula removal container limit.Check that mixture mixes homogeneous and checks from visual appearance guaranteeing.Single dose is joined in the bottle that has added sterilized water.The sample that takes out product is used for analyzing, and uses HPLC to determine the amount of active component.The visual appearance of preparation in the same assessment water.

When carrying out the multiple dose test, increase the amount of active component and excipient accordingly.

Embodiment 12

Adrenaline preparation (50mg dosage)

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Epinephrine
	50	10.40％
			Citric acid	120	24.94％
Sodium bicarbonate	60	12.47％
			Potassium bicarbonate	60	12.47％
Benzalkonium chloride	1	0.21％
			Sucrose
	40	8.32％
			Glucide
	125	25.99％
			The strawberry-flavoured agent	25	5.20％
The total amount of one dosage	481	100％

Use with embodiment 11 in identical method preparation and test said preparation.

Embodiment 13

Aceta Elixir (50mg dosage)

First preparation:

According to following composition and amount preparation said preparation.

Composition

Dosage mg

％W/W

Acetaminophen	1000	44.44％
			Ascorbic acid	100	4.44％
Citric acid	500	22.22％
			Sodium bicarbonate	300	13.33％
Potassium bicarbonate	300	13.33％
			Glucose
	20	0.89％
			Caffeine
	30	1.33％
			Amount to	2250	100％

Use the water mixing mentioned component of three kinds of different volumes to test: respectively at 20ml, in the different bottles of 40ml and 80ml.

The result:

Consider in bottle and to use the water of 80ml to obtain the good reaction and the suspension of acetaminophen, can think and use that still less the water of volume can be better.

In the situation of 40ml, use three kinds of different containers to test, be respectively graduated cylinder, beaker and bottling.In graduated cylinder, observed the foam (approximately 60ml) of certain volume.And the acetaminophen of a great deal of is still stayed on the limit of container separately and the surface of water.Acetaminophen is deposited to the bottom of bottle after 15 minutes.

The situation of 20ml is still used three kinds of different containers, is respectively beaker, the sampling container and the little bottling of lid arranged.The foam and the gas of a great deal of under each situation, have all been observed.Same, acetaminophen does not rest in the suspension, but rests on container edge, the top of water and the bottom of container separately.

Second preparation:

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Acetaminophen	1000	78.74％
Ascorbic acid	100	7.87％
			Citric acid	60	4.72％

Sodium bicarbonate

	30	2.36％
			Potassium bicarbonate
	30	2.36％
			Glucose
	20	1.57％
			Caffeine
	30	2.36％
			The total amount of one dosage	1270	100％

Using single volume (20ml), in two kinds of different vessels, is respectively little bottling and the sampling container that lid is arranged, and carries out the research of second preparation.

The result that second preparation obtains is only to have produced a spot of foam, and had only a spot of acetaminophen to rest on the top of water.In any case with respect to first preparation, the visual appearance of the second preparation integral body all has improvement.

Conclusion:

Acetaminophen is unstable and do not rest in the suspension in water.But, can be that the amount of citric acid, sodium bicarbonate and calcium bicarbonate minimizes the gas of generation and foam by reducing foaming agent, with obtain can administration from container of the present invention drinkable preparation.

Embodiment 14

The Motrin test

First preparation:

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Ibuprofen	200	62.50％
Citric acid	60	18.75％
			Sodium bicarbonate
	30	9.38％
			Potassium bicarbonate
	30	9.38％
			The total amount of one dosage	320	100％

Use the water of two kinds of volumes to test, i.e. 20ml and 40ml, in two different containers, promptly little bottling and beaker.

The result:

-only observe a spot of foam; Some granules are in suspension and the top of water according to observations.

-water becomes white.

Second preparation:

According to following composition and amount preparation said preparation.

Composition	Dosage mg	％W/W
			Ibuprofen	200	45.45％
Citric acid	120	27.27％
			Sodium bicarbonate	60	13.64％
Potassium bicarbonate	60	13.64％
			The total amount of one dosage	440	100％

The water that uses a kind of volume is that 20ml and a kind of container are to test in the little bottling.

The result:

-original observed is to foam.

-then rock and observe small amount of foam.

Do not observe the granule of ibuprofen in the-water.

-water becomes white.

Conclusion:

In the situation of two kinds of preparations, tested the characteristic of ibuprofen in water in the above, and by increasing citric acid, the amount of sodium bicarbonate and calcium bicarbonate has been optimized foamy generation.

In two kinds of preparations, second preparation has preferable performance.

Conclusion is that ibuprofen is unstable and can not rest in the suspension in water.But it is suitable for the preparation as a kind of administration from container of the present invention.

Embodiment 15

Probiotics preparation

(0.1 gram dosage)

Prepare probiotics preparation according to following composition.

Composition	Dosage (g)	％W/W
			Probiotic bacteria: bacillus acidophilus	0.1	1.5％
Prebiotics: inulin/fructooligosaccharides	5.5	79.7％
			Cholesterol-lowering agent: sterol ester	1.3	18.8％
Amount to	320	100％

Process:

Step 1: will with trade mark Duolac sell from Cell Biotech Ltd., the double-deck lactobacillus that Seoul, South Korea obtain is the lactobacterium acidophilus, the inulin/fructooligosaccharides (Frutafit CLR (trade mark)) that obtains from Senus Ingerdients and the sterol ester (Vegapure 67 WDP (trade mark)) that obtains from Cognis take by weighing the amount that can be used for 10 doses.

Step 2: three kinds of compositions are joined in 1 liter the hydrostatic column, and firmly rock container and it was mixed fully in two minutes.By determining after a series of bulk testing that best mixing time is 2 minutes.In 2 minutes incorporation time, obtained uniform mixed style.

Step 3: the step 2 of a dosage is obtained mixture join in second compartment in the two Compartment comtainers of the present invention.From Reagecon, purify waste water (40ml) that Shannon, Ireland obtain joins in first compartment.Clockwise rotate shell opening sealing, thereby allow water to mix with powder composition.5 seconds of shake mix firmly.At last, inhour is rotated the following character of removing lid and estimating the aqueous medium of forming:

-mixed-powder is dissolubility in aqueous medium.

The residual minim of-powder on base wall.

The result:

-obtain aqueous medium completely.

There is not powder residual on the-chamber wall.

-add flavoring agent (0.2% the Pericarpium Citri tangerinae that Synergy Flavours provides, 0.2% tropical plants, 0.2% Fructus Citri tangerinae or 0.2% Fructus Mali pumilae) in purify waste water the dissolubility of mixed-powder is not had adverse influence.

Use following probiotic bacteria to repeat embodiment 15 and obtain comparing result:

The source	Probiotic bacteria
		Cell Biotech，Ltd.	The streptococcus thermophilus bifidobacterium longum is had a liking for the yogurt coccus
Institut Rosell	Bacillus acidophilus's bifidobacterium longum streptococcus thermophilus bacillus acidophilus (microcapsule) bifidobacterium longum (microcapsule) streptococcus thermophilus (microcapsule)
		Brewster Foods	Bacillus acidophilus's bifidobacterium bifidum
Danisco	Bacillus acidophilus's Bifidobacterium lactis
		Nebraska Cultures	Lactobacillus brevis Lactobacillus bulgaricus lactobacillus casei Bifidobacterium lactis streptococcus thermophilus

Embodiment 16

The prebiotics preparation

(5.5 gram dosage)

Prepare the prebiotics preparation according to following composition.

Composition	Dosage (g)	％W/W
			Prebiotics: natural inulin/fructooligosaccharides	5.5	79.7％
Probiotic bacteria: streptococcus thermophilus	0.1	1.5％
			Cholesterol-lowering agent: sterol ester	1.3	18.8％
The total amount of one dosage	6.9	100％

Process:

Carry out the step 1-3 among the embodiment 15, just in step 3, firmly rock 10 seconds of container.Streptococcus thermophilus is from Cell Biotech Ltd., Seoul, and South Korea obtains, and inulin/fructooligosaccharides (Frutafit CLR (trade mark)) obtains from Senus Ingerdients, and sterol ester (Vegapure 67 WDP (trade mark)) obtains from Cognis.

The result:

-obtain aqueous medium completely.

-add flavoring agent (0.2% the Pericarpium Citri tangerinae that Synergy Flavours provides, 0.2% tropical plants, 0.2% Fructus Citri tangerinae or 0.2% Fructus Mali pumilae) in purify waste water the dissolubility of mixed-powder is not had adverse influence.

Use following probiotic bacteria to repeat embodiment 16 to obtain comparing result:

The source	Prebiotics	Trade mark
			Orafti Active Food Ingredients	Oligofructose	Raftilose P95
Orafti Active Food Ingredients	Inulin	Raftiline GR
			Cosucra Warcoing	Oligofructose	Fibrulose F97
Cosucra Warcoing	Inulin	Fibruline Instant

Embodiment 17

The cholesterol reducing preparation

(5.5 gram dosage)

Prepare the cholesterol reducing preparation according to following composition.

Composition	Dosage (g)	％W/W
			Cholesterol-lowering agent: plant sterol	1.3	18.8％
Probiotic bacteria: bifidobacterium bifidum	0.1	1.5％
			Prebiotics: natural inulin	5.5	79.7％
The total amount of one dosage	6.9	100％

Process:

Carry out the step 1-3 among the embodiment 15.Bifidobacterium bifidum obtains from Brewster Foods, inulin/fructooligosaccharides (Frutafit IQ (trade mark)) obtains and plant sterol from Senus Ingerdients, and CardioAid-M (trade mark) obtains from ADM-Archer Daniels Midland Company.

The result:

-obtain aqueous medium completely.

-add flavoring agent (0.2% the Pericarpium Citri tangerinae that Synergy Flavours provides, 0.2% tropical plants, 0.2% Fructus Citri tangerinae or 0.2% Fructus Mali pumilae) in purify waste water the dissolubility of mixed-powder is not had adverse influence.

Use following cholesterol-lowering agent to repeat embodiment 17 to obtain comparing result:

The source	Prebiotics	Trade mark
			ADM	Plant sterol ester	CardioAid-GA
ADM	Plant sterol-sucrose fatty acid ester composition	CardioAid-WD

********

The vitamin E (0.05g) that ascorbic acid (0.5g) that O ' Brien Ingredients is provided and Eastman provide is successfully sneaked in every kind of mixed-powder describing among the embodiment 15-17.The corresponding consumption that reduces prebiotics among each embodiment.

Embodiment 18-20

The bi-component polymeric preparation

Embodiment	Principal agent	Catalyst	Xiao A hardness
				18	10 parts of polysiloxanes Moldsil F	1 part of Moldsil thixo additive	22
19	4 parts of polyurethane Poly74-65 principal agents	1 part of Poly 74-65 additive	65
				20	2 parts of polyurethane Poly74-40 principal agents	1 part of Poly 74-40 additive	40

All use of the present invention pair of chamber container in each embodiment, when sealing member broke a seal, catalyst (being contained in first compartment) mixed with principal agent (being contained in second compartment).In these embodiments, all raw materials provide by W.P.Notcutt Ltd..

When two kinds of compositions mix, these two component system have been formed.Use container of the present invention to guarantee the catalyst of the correct amount of each use, eliminated the possibility of people's operate miss.

Embodiment 21-22

Bi-component chromotrichia preparation

Embodiment	The chromotrichia product	Coloring agent	Painted active Emulsion
				21	Laboratoires Garnier (bi-component is regulated the emulsion coloring agent)	1 part	1 part

22

Clariol nice ' n easy (nice ' n easy be trade mark) (the natural gloss color-grade 3-is permanent)

1 part

2 parts

In each embodiment, all use of the present invention pair of chamber container, use a kind of " purified solution " to mix the bi-component hair coloring agents.When sealing member broke a seal, painted activating agent or developer (being contained in first compartment) mixed with coloring agent (being contained in second compartment).Use this activation of hair coloring agent then in a usual manner.Therefore,

The possibility that the people slips up has been eliminated in the use of container of the present invention in the process of preparation hair coloring agents.

The accompanying drawing summary

Fig. 1 is the diagram that is used to prepare the formulation in liquid form container according to of the present invention;

Fig. 2 is the cross-sectional view of Fig. 1 along the II-II line;

Fig. 3 is the exploded view of Fig. 1 container;

Fig. 4 is the diagram of second embodiment of the invention container;

Fig. 5 is the cross-sectional view of Fig. 4 along the V-V line;

Fig. 6 is the exploded view of Fig. 4 container;

Fig. 7 is the diagram according to the container of third embodiment of the invention;

Fig. 8 is the cross-sectional view of Fig. 7 along the VIII-VIII line, and wherein sealing member is in its closed position;

Fig. 9 is the cross-sectional view of Fig. 7 container, and wherein sealing member is located in the release position;

Figure 10 is the exploded view of Fig. 7 container;

Figure 11 is the diagram according to the container of four embodiment of the invention;

Figure 12 is the cross-sectional view of Figure 11 along the XXI-XII line, and wherein sealing member is in its closed position; And

Figure 13 is the cross-sectional view of Figure 11 container, and wherein sealing member is located in the release position.

With reference to figure 1, a kind of container for oral delivery liquid-type pharmaceutical preparation shown in it, usually with Reference numeral 10 expressions, container 10 has be used to the first component 11 that fills a certain amount of drinkable liquid, and is used for filling the second component 12 of a certain amount of active component.

Container 10 has the bottle-shaped end, has neck type parts 14 at one end 13, is fixed for the anti-tampering seal that stores on it.

Second component 12 is connected on the first component 11, so that two parts can vertically moving with respect to the other side along container 10.

With reference to figure 2, can observe container 10 from more details. Seal closure 15 is fixed to the neck type parts 14 of first component 11. Screw thread on the neck type parts 14 of the screw thread on the inner surface 17 of seal closure 15 and first component 11 matches.

On the other end 19 of first component 11, has annular groove 21 in the annular shoulder 20.

Second component 12 is cylindrical and at one end has base portion 22 on 23 that have loop configuration 24 at the other end 25, its annular groove 21 on first component 11 is assembled into snap fit.

Circular salable barrier film 26 separates first component 11 and second component 12. A plurality of vertical pieces 27 are arranged on the circumferentia 28 of barrier film 26. Have screw thread 29 on the outer surface 30 of these sheets 27, wherein screw thread 29 matches with the additional screw thread 31 of the inner surface of first component 11. When storing, barrier film 26 forms sealing with the end 19 of first component 11.

A large amount of parts 33 are arranged on the inner surface 34 of second component 12. The lower surface 36 that these parts 33 are arranged in barrier film 26 has on the end 35 of a large amount of fluting (not shown).

During use, partially filled drinkable liquid in the first component 11, and active component is arranged in second component 12. When storing, isolated by salable barrier film 26 between liquid and the active component. When needs formed and draw preparation, two parts 11 and 12 were rotated movement with respect to the other side. This rotary moving is so that parts 33 touch the edge of the fluting in the barrier film 26, so that it outwards winding from first component, thereby destroyed sealing between parts 11 and the barrier film 26, obtains the passage that drinkable liquid enters second component 12. Then rock container 10 and form preparation with mixed active composition and drinkable liquid, preparation can be drawn after seal closure 15 is removed.

With reference to figure 3, show the exploded view of Fig. 1 container. By formation sealing between the two in the end 19 that barrier film 26 is screwed in first component 11, thereby fill described container. Then in parts 11, fill a certain amount of drinkable liquid, and anti-tampering seal closure 15 is screwed on the neck type parts 14. A certain amount of active component is arranged in second component 12, and by parts 24 are embedded in the groove 21 two parts 11,12 is linked together, thereby has guaranteed that parts 33 are arranged in the fluting of barrier film 26.

With reference to figure 4, the container of second embodiment of the invention shown in it is usually with Reference numeral 40 expressions. Container 40 is pitchers, and has the first component 41 that holds certain quantity of fluid and the second component 42 that holds a certain amount of active component. Two parts 41,42 link together by band shaped part part 43. Have neck type parts 45 on the end 44 of first component 11, be fixed with jamming-proof seal closure 46 on the neck type parts 45.

With reference to figure 5, show the cross-sectional view of container 40. Salable barrier film 47 is arranged in seal 48, and wherein seal 48 is arranged in the band shaped part part 43 of container 40.

Cylindrical prolongation connector 49 end 50 wherein is connected on the salable barrier film 47. Annular ring parts 51 are fixed on the other end 52 that prolongs connector 49. Annular ring parts 51 are positioned on the shoulder 53, and described interior shoulder is positioned on the neck type parts 45 of container 40. Additional screw thread 55 on screw thread 54 on the annular ring parts 51 and the inner surface 56 of seal closure 46 matches.

During use, a certain amount of active component is arranged in parts 42. Salable barrier film 47 is arranged in seal 48 and a certain amount of drinkable liquid is arranged in parts 41. Then the seal closure 46 of outwarding winding of the screw thread 57 on the neck type parts 45 of container 40. When needs form and draw preparation, continue from the neck type parts 45 of container 40 seal closure 46 of outwarding winding, until it breaks away from from the screw thread 57 on the neck type parts 45, it can rotate freely around it subsequently. Further rotate so that the additional screw thread on the inner surface 56 of the screw thread 54 on the annular ring parts 51 and seal closure 46 matches. Then continue hydrodynamic reciprocating sealing cover 46 so that barrier film 47 is mentioned from seal 48, thereby allow drinkable liquid to enter second component 42 and mix mutually with wherein active component. In case active component mixes mutually with liquid, seal closure 46 just can be removed, and the user just can drink the preparation that obtains.

It is cylindrical prolonging connector 49, and has a large amount of fluting 58 at its outer surface 59. These flutings 58 have supplied clear passage to liquid carrying in the first compartment 41.

With reference to figure 6, show the exploded view of container 40. Two parts 41,42 and their middle band shaped part parts 43 form the unitary plastic parts by blowing. Before these parts are placed in the container, seal 48 is placed on the barrier film 47.

With reference to figure 7, the container of third embodiment of the invention shown in it is usually with Reference numeral 70 expressions. Container 70 has the extension body 71 that is divided into first component 72 and second component 73 along its longitudinal axis. First component 72 is with 75 to form by shell 74 and Kaifeng, and Kaifeng is connected on the shell removedly with 75 edges 76 along shell 74.

With reference to figure 8, container 70 has inner room 77, and wherein inner room 77 is divided into the first compartment 78 and second compartment 79 by seal 80. In Fig. 8, seal 80 diagrams are in its closed position, so wherein the first compartment 78 and second component 79 seal.

Seal 80 is installed on the end 81 of shell body 82, and wherein shell body 82 is positioned at the first compartment 78 of inner room 77. The first compartment is normally cylindrical and 84 have an opening 83 in the end, and opening 83 is used for seal 80 is fixed on its closed position. The end 84 of the first compartment 78 is annular elements, concentrates in the literary composition to represent end and annular element with Reference numeral 84. The annular element 84 of extend through opening 83 has the larger diameter of ratio open 83.

Shell 74 is connected on the annular element 84 by clasp 85, and second component 73 is connected on the annular element 84 by clasp 86.

Has opening 88 in the other end 87 of the first compartment 78. End 87 is arranged in the upstanding part-annular wall 89 of the inner surface 90 of shell 74, wherein the hermetic terminal 87 of inner surface 90. The other end 91 of extension body 82 is arranged in opening 88. End 91 is open, and for the upstanding part-annular wall 92 on the inner surface 90 that holds shell 74. Interior upstanding part-annular wall 92 has four open flutings, each 93 and refill component 94 co-operating of slotting, fluting is positioned on the other end 91 of extension body 82, so that seal 80 moves to release position (Fig. 9) from its closed position (Fig. 8).

With reference to figure 9, four patterns 95 on the end 81 of shell body 82 provide clear passage for the inclusion in the inner room 77, and wherein seal 80 is positioned at the place, release position.

Figure 10 is the exploded view of container 70, for the sake of clarity, shows respectively shell 74, the first compartment 78, shell body 82 and second component 73.

Can observe in more detail the parts 94 on the other end 91 of shell body 82. Each parts 94 is forms of flexible flange 96, and in the end 98 of parts rectangle projection 97 is installed. The outer rim 99 of each rectangle projection 97 is positioned within the fluting corresponding on the shell body 74 93 (Fig. 8 and 9). Edge 100 opposed ends 91 of each flange 96 tilt, and dwindle into the otch 101 on shell body 82 surfaces 102. Otch 101 offers flange 96 with pliability.

Four inclined planes 103 are positioned on the inner surface 104 of end 87 of the first compartment 78. When assembling container 70, seal 80 is positioned at sealing place, align with end 87 in the end 91 of shell body 82, each rectangular flange 96 is positioned at the first groove 105 on the inner surface 104, and the outer rim 99 of each rectangle projection 97 is placed in the corresponding fluting 93. In same position, the inclined side 100 of each flange rests on the corresponding inclined plane 103, and inclined plane 103 is positioned within the corresponding otch 101 fully. Along the direction rotation shell 74 of arrow A so that prolong inner bulk 82 same with respect to 78 rotations of the first compartment, move on the track 103 that each inclined side 100 is relatively corresponding simultaneously and each rectangle projection 97 on move on the relatively corresponding fluting 93. When each rectangle projection 97 arrives and enters in the second groove of inner surface 104, stoped being moved further and so that seal 80 arrival release positions of extension inner bulk.

Shell 74 is further rotated along equidirectional, for the not impact of position of shell body 82, because the rectangle projection will break away from from the fluting 93 of correspondence.

When assembling container 70, the convex annular wall 109 on the edge 108 adjacency annular elements 84 of the first compartment 78 of the second compartment 73. Four projections 110 on the edge 108 are positioned within the fluting 110 of corresponding convex annular wall 109, and have stoped the movement of the second compartment with respect to the first compartment.

When assembling, annular Kaifeng is with 75 equally in abutting connection with convex annular wall 109. Four elasticity stitch 112 are looped around annular Kaifeng with on 75 the edge 113. Each stitch 112 by moulding with when shell 74 a large amount of grooves 114 that replenish in the turnover convex annular wall 109 along the direction rotation of arrow A the time. But when if shell 74 moves along opposite direction, each assiatant 112 will enter to replenish groove 114 and break a seal and will be positioned at the positions of pinning with respect to compartment 78 with 75. Anyly attempt along that direction mobile shell 74, all will so that shell 74 115 break away from Kaifeng and be with 75 along the junction. Junction 115 is zigzag and therefore so that clasp 85 makes shell 74 remove from container 70 easily.

In order to assemble the use container, inner shell body 82 is placed in the first compartment 78, and wherein seal 80 is positioned at its closed position. Active component is positioned at the second compartment 79, and second component 73 is connected on the first compartment 78. A certain amount of liquid is positioned at the first compartment 78 and shell 74 is connected thereto. Then the container that assembles is positioned in the suitable reservoir vessel (not shown), until need to form preparation.

When needs form preparation, from reservoir vessel, take out container 70, and the direction rotation of shell body 74 along arrow A, hold simultaneously second component 73. This seal 80 of rotatablely moving moves to the release position from sealing, thereby allows active component to mix with a certain amount of liquid. When mixing was finished, then reverse rotation can shift out preparation except decapsidate 74 from container 70.

In another embodiment (not shown) of the lid 74 of container 70, the open fluting of each in the interior upstanding part-annular wall 92 93 is replaced by cup, and wherein rectangle projection 97 is positioned at sealing place. Shell 74 causes that along the rotation of arrow A direction each wall of cup of inner shell body 82 promotes corresponding rectangle projection 97 along the rotation of same direction.

When each rectangle projection 97 arrived and enters in the second groove 107, it had broken away from corresponding wall of cup, so the position that is moved further for extension body 82 of shell 74 same directions does not affect.

With reference to Figure 11, the container of four embodiment of the invention shown in it is usually with Reference numeral 120 expressions. Container 120 has the extension body 121 that is divided into first component 122 and second component 123 along its longitudinal axis. First component is comprised of shell 124 and Sealing strap 125, and Sealing strap 125 is connected on the shell 124 removedly along the edge 126 of shell 124.

With reference to Figure 12, container 120 has inner cavity chamber 127, and wherein inner cavity chamber 127 is divided into the first compartment 128, the second compartment 129 and the 3rd compartment 130 by seal. Seal 131 shown in Figure 12 is positioned at sealing place, therefore seals the first compartment 128, the second compartment 129 and the 3rd compartment 130.

Seal 131 is installed on the end 132 of elongation connector 133, wherein extends the first compartment 128 that connector 133 is positioned at inner cavity chamber 127. The first compartment 128 is normally cylindrical, has opening 134 at one end 135, and opening 134 is used for seal 131 is fixed on its closed position.

Shell 124 and second component 123 are installed on the end 135 of the first compartment, and by the annular wall 136 on the end 135 separately. Shell 124 and second component 123 are fixed by clasp 137 and 138 respectively.

The other end 139 of the first compartment 128 has opening 140. End 139 is arranged in the upstanding part-annular wall 141 of the inner surface 142 of shell 124, wherein inner surface 142 hermetic terminals 139. The other end 143 of elongation connector 133 is arranged in opening 139. End 143 is open, and for the upstanding part-annular wall 144 on the inner surface 142 that holds shell 124. Interior upstanding part-annular wall 144 has four open flutings 145, each 145 and refill component 146 co-operating of slotting, be positioned on the other end 143 of elongation connector 133, so that seal 131 moves to release position (Figure 13) from its closed position (Figure 12).

With reference to Figure 13, four patterns 147 on the end 132 of elongation connector 133 provide clear passage for the inclusion in the inner room 127, and wherein seal 131 is positioned at the release position. The clear passages of the inclusion that extends out parts 148 same assistance formation inner rooms 127 of the first compartment 128.

During use, shell 124 along arrow B direction (Figure 11) with respect to the rotation of second component 123 so that seal 131 moves to release position (Figure 13) from sealing (Figure 12). Be used for causing that the structure (not shown) that elongation connector 133 moves is similar to the embodiment shown in Fig. 7-10. But in this embodiment, elongation connector 133 stretches to the inner surface 142 of shell body 124, rather than leaves inner surface 142, and this is because seal 131 has moved into the release position.

Again with reference to Figure 11, shell 124 along in contrast to the movement of arrow B direction so that Kaifeng enter within the additional fluting 150 in the wall 136 with the stitch 149 on 125, thereby pinned stitch 149. Being moved further of this direction caused junction 141 along the edge 126 shearing force, then shell 124 removes from container 120. The zigzag fashion at edge 126 will be convenient to carry out shell and be removed.

Claims (50)

1. container that is used to form formulation in liquid form, described container comprises the elongation shell body that is divided into several parts along its longitudinal axis, the inner cavity chamber that is divided into two or more compartments, sealing member and sealing member is remained on the device of release position movably, described sealing member moves to the release position from the detent position that seals all compartments during use, wherein all compartments all do not have sealed and all the elements thing wherein freely mixes in inner cavity chamber and forms preparation when the release position, described sealing member can move to the release position with respect to its other partial rotation from detent position by a part that makes shell body, thereby after compartment is disengaged sealing the volume of inner cavity chamber is remained unchanged.

2. the container of claim 1, wherein said shell body is generally cylindrical, and is separated into two general barrel portions, described two parts are docking together to allow relatively moving between the two.

3. the container of claim 2, wherein said two parts are by being fastened and connected together.

4. claim 2 or 3 container, wherein said sealing member is circular spacer, and when it is in detent position, be connected in these parts by its outer periphery threads district on one the interior threaded surface, thereby the rotation of one part makes sealing member outward winding, and makes it from the detent position to the release position and leave thread surface.

5. the container of claim 1, wherein said sealing member is installed in an end of elongation connector, wherein extend first compartment that connector can be positioned at inner cavity chamber, the end of prolate body is away from the sealing member that has structure on it, and this sealing member can match with the supplementing structure on the shell body part inner surface that covers compartment.

6. the container of claim 5, wherein said shell body is general cylindrical and is separated into two general column parts, first has an opening at the one end, this opening is sealed by second portion by the screw thread sealing during storage, and sealing member moves to the release position by the opening movement that seals in use.

7. the container of claim 6, wherein said opening is positioned at the neck type part of first, described neck type partly has the screw thread that is positioned on its outer surface, be used to make threads engaged on sealing and its inner surface, female thread and the threaded area co-operating of extending the connector other end, make the opening movement of sealing cause prolate body to be outwarded winding, make sealing member move to the release position then from neck type part.

8. the container of claim 5, first compartment of wherein said inner cavity chamber all has the generally cylindrical of opening for each end, elongation connector in wherein can settling, and opening is fit to sealing member is installed in its closed position, and the other end is fit to prolate body is linked together away from the supplementing structure on the inner surface of an end of sealing member and the shell body part that covers described first compartment.

9. the container of claim 8, place, compartment top position in wherein said shell body part is fixed on by the loop seal band.

10. the container of claim 9, wherein said shell body part and loop seal band can be along direction rotations, described rotation causes the sealing member displacement, and the trial of wherein rotating described shell body part in the opposite direction causes shell to leave the Kaifeng bar, thereby the shell body part is removed from this container.

11. each container among the claim 8-10, wherein said first compartment is connected to other shell body part at the end that can settle sealing member, and described other shell body partly has and is positioned at one or more other compartment.

12. the container of claim 11, wherein when other shell body part only had a compartment that is positioned at wherein, sealing member can enter this compartment and move to the release position.

13. the container of claim 12, wherein in use, the rotation of described shell body part causes the corresponding rotation of first compartment with respect to other shell body part, and the elongation housing moves along the corresponding inclination extension on the first compartment inner surface away from the sloping edge on sealing member one end, make the elongation housing be shifted, so that sealing member moves to the release position along the longitudinal axis of container.

14. the container of claim 12 or 13, wherein at place, described release position, the supplementing structure on structure on the described elongation connector and the shell body part irreversibly breaks away from.

15. the container of claim 11, wherein when other shell body partly had the compartment that is positioned at wherein of surpassing, sealing member can be removed from these compartments and enter into the release position.

16. each container in the aforementioned claim, one of them compartment is suitable for holding certain amount of fluid, and another or each other compartment are suitable for holding a certain amount of active component.

17. the container of claim 16, wherein said liquid is aqueous medium.

18. the container of claim 16 or 17, wherein said active component water soluble.

19. the container of claim 16 or 17, wherein said active component is water insoluble.

20. each container among the claim 16-19, wherein said active component are powder type.

21. the container of claim 20, wherein said powder particle is a micron particles.

22. the container of claim 20, wherein said powder particle is a nano-scale particle.

23. each container among the claim 16-22, a wherein said compartment also can hold active component before mixing.

24. each container among the claim 16-23, wherein said preparation is used to be delivered to people or non-human animal.

25. the container of claim 24, wherein said preparation is suitable for oral delivery.

26. each container among the claim 16-25, wherein said active component are selected from health care water, nutritional drugs, medicine, alcoholic beverage, non-alcoholic beverage, food, homeopathic therapeutic method's medicament, prebiotics, probiotic bacteria or its mixture.

27. the container of claim 26, wherein said active component is a probiotic bacteria, and described probiotic bacteria can provide 100% active probiotic preparation at the most be stored to many 3 years with dried forms after.

28. the container of claim 26 or 27, wherein said probiotic bacteria are the bacterial strains of probiotic bacteria, described probiotic bacteria antibacterial is selected from lactobacillus, bacillus bifidus, streptococcus faecalis and streptococcus thermophilus, enterococcus and solidifies bacillus cereus.

29. each container among the claim 26-28, it comprises prebiotics.

30. the container of claim 28, wherein prebiotics is selected from glucide, inulin base prebiotics material, Bulbus Allii and extract, Mel and extract thereof and dietary fiber, described glucide comprises monosaccharide, disaccharide, oligosaccharide and/or polysaccharide, and wherein monomeric unit is selected from fructose, galactose, glucose and maltose.

31. each container among the claim 26-30, wherein said preparation does not contain lipid material.

32. each container among the claim 20-31, wherein said powder particle have the particle form that allows active component controlled release in gastrointestinal tract.

33. the container of claim 32, wherein said granule has different release profiles.

34. the container of claim 32 or 33, wherein said granule are coated with one or more polymeric materials to realize described release.

35. each container among the claim 32-34, wherein said granule comprise a certain proportion of can be when drawing preparation the granule of rapid release active component.

36. each container among the claim 26-35, wherein said preparation comprises one or more excipient, and described excipient is selected from absorption enhancer, acid regulator, antioxidant, foaming agent, flavoring agent, fusion inhibitor, pH regulator agent, antiseptic, solubilizing agent, sweeting agent and sense of taste masking agent.

37. each container among the claim 26-36, wherein said active component is a medicine, is selected from adrenaline excitant, adrenergic blocker, adrenocortical hormone, the smoking cessation agent, anobolite, analgesics, androgen, antacid, antiabnormal reaction agent, anti-asthmatic agent, antibiotic, anticarcinogen, antidepressants, antidiabetic drug, anti-diarrhea agents, antiemetic, Anti-epileptics, the gout agent, antihypertensive, anti-infective, antimigraine, appetrol, antianxiety drugs, bronchodilator, contraceptive, cytokine, dietary supplement, the intestines and stomach agent, hormone, laxative, local anesthetic, lymphokine, mucolytic agent, non-steroidal anti-inflammatory agent, steroid, vaccine and vitamin.

38. the container of claim 26, wherein said preparation is applicable to topical.

39. the container of claim 38, it is used to send hair dye.

40. the container of claim 38, it is used for formulation delivered to vagina.

41. the container of claim 40, wherein said preparation are the forms of irrigating solution.

42. the container of claim 40 or 41, wherein active component is a probiotic bacteria.

43. the container of claim 42, it comprises prebiotics.

44. each container in the aforementioned claim, the volume of wherein said liquid preparation is at most 5000ml.

45. each container among the claim 1-15, wherein said container is used to form air freshener.

46. each container among the claim 1-15, it is used to form fuel.

47. the container of claim 46, wherein component separately is gasoline and oil.

48. the container of claim 47, wherein gasoline is used for two-cycle engine with oily ratio with 40: 1.

49. the container of claim 16, wherein liquid and active component or every kind of active component are the compositions that is used to form adhesive or glue.

50. the container that is used to form formulation in liquid form of claim 1 is basic as have the mentioned above of concrete Reference numeral, and as shown in Fig. 1-3, Fig. 4-6, Fig. 7-10 and Figure 11-13 of accompanying drawing.

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