CN1295548A - 新的三环化合物 - Google Patents

新的三环化合物 Download PDF

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CN1295548A
CN1295548A CN99804345A CN99804345A CN1295548A CN 1295548 A CN1295548 A CN 1295548A CN 99804345 A CN99804345 A CN 99804345A CN 99804345 A CN99804345 A CN 99804345A CN 1295548 A CN1295548 A CN 1295548A
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CN1231440C (zh
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谷本宪彦
长谷川靖
芳贺展弘
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Shionogi and Co Ltd
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Abstract

本发明提供式(Ⅰ)化合物,其中A环、B环和C环各自独立为取代的或未取代的芳族环或可以与苯环稠合的取代的或未取代的5－或6－元杂环,当A环、B环和/或C环为取代的或未取代的5－元杂环时,W1、W2和/或W3表示键,X为D或－NR1－(其中R1为氢、低级烷基等),Y为氢、低级烷基、低级链烯基等,V1和V2之一为单键,而另一个为单键、－O－等,和含有该化合物的药物。

Description

新的三环化合物
技术领域
本发明涉及新的三环化合物和用作免疫抑制剂、抗过敏剂或IgE产生的抑制剂的含有该化合物的药用组合物。
背景技术
近年来，进行组织或器官移植时经常遇到的一个严重问题就是手术后排斥移植部分的排斥症状。预防排斥症状对移植的成功是非常重要的。
各种免疫抑制剂，如硫唑嘌呤、类皮质激素、环孢菌素A、他克莫司等已被开发出来，并开始投入到预防和治疗针对器官或组织移植或因骨髓移植引起的移植物对宿主反应的实际应用中。但鉴于它们的效果及副作用，这些免疫抑制剂并不那么令人满意。
近年来，过敏性疾病，如特应性皮炎、过敏性鼻炎、支气管哮喘、过敏性结膜炎等，在全球范围内趋向于增加并成为严重的问题。常规的抗炎药为自肥大细胞释放化学介质的抑制剂，已释放的化学介质的受体抑制剂、过敏性炎症反应的抑制剂等。所有这些药物均是用于症状缓解疗法的药物，并不是用于过敏性疾病的根本的治疗剂。
因此，一直在期待着开发更有效和更安全的药物。
WO94/27980、WO95/13067、WO96/40659、WO96/40143、WO96/38412、WO97/24356、WO97/24324、WO97/46524、JP-A8-3163、JP-A9-12457、JP-A9-71564、JP-A9-124571等描述了具有与本发明化合物类似的结构并表现出免疫抑制或抗过敏作用的许多化合物。JP-A9-87253、JP-A63-253065、JP-A1-106864、JP-A1-106871、JP-A2-83346、JP-A9-48760、JP-A9-31063等描述了液晶化合物，JP-A8-193067描述了显示出杀昆虫剂或杀螨剂活性的化合物，EP0600717A1描述了对循环系统疾病或精神病有治疗活性的化合物，所有这些化合物均具有与本发明化合物类似的结构。本发明的公开
本发明提供式(Ⅰ)化合物、其药学上可接受的盐或水合物：
Figure 9980434500161
I其中A环、B环和C环各自独立为任选取代的芳族碳环或可以与苯环稠合的任选取代的5-或6-元杂环，当A环、B环和/或C环为任选取代的5-元杂环时，W1、W2和/或W3表示键，X为-O-、-CH2-、-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基或-S(O)p-，其中p为0-2的整数，Y为氢、任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的酰基、任选取代的环烷基、任选取代的环烯基、任选取代的低级烷氧基羰基、任选取代的氨磺酰基、任选取代的氨基、任选取代的芳基或任选取代的5-或6-元杂环，当X为-CH2-时，Y可以是任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可以是任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，V1和V2之一为键，而另一个为键、-O-、-NH-、-OCH2-、-CH2O-、-CH=CH-、-C≡C-、-CH(OR2)-，其中R2为氢或低级烷基、-CO-或-NHCHR3-，其中R3为氢或羟基，及当V1和V2均为单键时，A环、B环和C环中至少一个为任选取代的芳族碳环和至少另一个为可以与苯环稠合的任选取代的5-或6-元杂环。
本发明提供用作免疫抑制剂、抗过敏剂或IgE产生的抑制剂的药用组合物，它包含化合物(Ⅰ)、其药学上可接受的盐或水合物。
在一个其它的实施方案中，本发明提供包括给予化合物(Ⅰ)在内的抑制免疫应答的方法或治疗和/或预防过敏性疾病的方法。在另一个实施方案中，本发明提供化合物(Ⅰ)在制备用于抑制免疫应答或治疗和/或预防过敏性疾病的药物中的用途。
在本说明书中，术语“卤素”包括氟、氯、溴和碘。氟或氯为优选的。
术语“低级烷基”包括具有1-10个碳原子，优选1-8个碳原子，更优选1-6个碳原子，及最优选1-3个碳原子的直链或支链烷基。例如，包括甲基、乙基、正丙基、异丙基、正丁基、异丁基、仲丁基、叔丁基、正戊基、异戊基、新戊基、己基、异己基、正庚基、异庚基、正辛基、异辛基、正壬基、正癸基等。
作为“任选取代的低级烷基”的示例性取代基有卤素、羟基、由低级烷氧基任选取代的低级烷氧基、酰基、酰氧基、羧基、低级烷氧基羰基、巯基、低级烷硫基、由羟基、低级烷基或任选取代的酰基任选取代的氨基、由羟基、低级烷氧基、羧基(低级)烷氧基、芳基(低级)烷氧基或5-或6-元杂环任选取代的亚氨基、由氨基甲酰基或低级烷氧基羰基任选取代的亚肼基、由低级烷基或氨基任选取代的氨基甲酰基、由低级烷基任选取代的硫代氨基甲酰基、由低级烷基或低级烷氧基任选取代的环烷基、由低级烷基任选取代的环烯基、由至少一个选自羟基、低级烷基、羧基、低级烷氧基羰基和低级烷氧基的取代基任选取代的苯基、可由低级烷基取代的和可与苯环稠合的5-或6-元杂环，等等。所述低级烷基可由一个或多个这些取代基在任何可能的位置上取代。卤素、羟基、酰氧基、由低级烷基或低级烷氧基任选取代的苯基、吡啶基等是优选的。
“低级烷氧基”的低级烷基部分与上述“低级烷基”相同。
作为“任选取代的低级烷氧基”的示例性取代基有卤素、羟基、由酰氧基任选取代的低级烷氧基、酰基、由羟基或羧基任选取代的酰氧基、羧基、低级烷氧基羰基、低级烷硫基、由低级烷基任选取代的氨基、由低级烷基或低级烷氧基任选取代的苯基、杂环、杂环基羰基氧基等。
“低级烷氧基羰基”、“低级烷基磺酰基”、“低级烷基磺酰基氧基”、“低级烷硫基”、“低级烷基氨基”和“低级亚烷基二氧基”中的低级烷基部分与上述“低级烷基”相同。对于“任选取代的低级烷氧基羰基”、“任选取代的低级烷基磺酰基”和“任选取代的低级烷硫基”的取代基与上述“任选取代的低级烷氧基”的相同。
术语“低级链烯基”包括2-10个碳原子，优选2-8个碳原子，更优选3-6个碳原子的在任何可能的位置上具有至少一个双键的直链或支链链烯基。例如，包括乙烯基、丙烯基如2-丙烯基等、异丙烯基、丁烯基、异丁烯基、异戊二烯基、丁二烯基、戊烯基、异戊烯基、戊二烯基、己烯基、异己烯基、己二烯基、庚烯基、辛烯基、壬烯基、癸烯基等。对于“任选取代的低级链烯基”的取代基与对于上述的“任选取代的低级烷氧基”的取代基相同，优选由卤素取代的链烯基或未取代的链烯基。
“低级链烯基氧基”、“低级链烯基氧基羰基”和“低级链烯基氨基”的低级链烯基部分与上述“低级链烯基”相同。对于“任选取代的低级链烯基氧基”、“任选取代的低级链烯基氧基羰基”和“任选取代的低级链烯基硫基”的取代基与上述“任选取代的低级烷氧基”的取代基相同。
术语“低级链炔基”包括2-10个碳原子，优选2-8个碳原子，更优选3-6个碳原子的直链或支链炔基，其示例有乙炔基、丙炔基如2-丙炔基等、丁炔基如2-丁炔基、戊炔基、己炔基、庚炔基、辛炔基、壬炔基、癸炔基等。这些基团在任何可能的位置上至少有一个三键并可以有数个双键。对于“任选取代的低级链炔基”的取代基与对于上述的“任选取代的低级烷氧基”的取代基相同。
术语“酰基”包括具有1-20个碳原子，优选1-15个碳原子，更优选1-8个碳原子，更优选1-6个碳原子，最优选1-4个碳原子的直链或支链脂族酰基，具有4-9个碳原子，优选4-7个碳原子的环状脂族酰基和芳酰基。例如，包括甲酰基、乙酰基、丙酰基、丁酰基、异丁酰基、戊酰基、新戊酰基、己酰基、丙烯酰基、丙炔酰基、异丁烯酰基、丁烯酰基、环丙基羰基、环己基羰基、环辛基羰基、苯甲酰基等。对于“任选取代的酰基”的取代基与对于上述的“任选取代的低级烷氧基”的取代基相同，芳酰基还可由低级烷基取代。在这些取代基中，优选卤素。
“酰氧基”中的酰基部分与上述的“酰基”相同，对于“任选取代的酰氧基”的取代基与对于上述的“任选取代的酰基”的取代基相同。
术语“低级烷基羰基”包括具有2-4个碳原子的脂族酰基，包括乙酰基、丙酰基、丁酰基、异丁酰等。优选乙酰基。
术语“环烷基”包括具有3-6个碳原子的碳环，如环丙基、环丁基、环戊基、环己基等。作为“任选取代的环烷基”的示例性取代基有低级烷基、卤素、羟基、羧基、低级烷氧基羰基、低级烷氧基、低级亚烷基二氧基、由低级烷氧基任选取代的亚氨基、芳基、5-或6-元杂环等，所述环烷基可在任何可能的位置上被取代。
术语“环烯基”包括在上述环烷基的任何可能位置上具有至少一个双键的基团，其实例有环丙烯基、环丁烯基、环戊烯基、环己烯基、环己二烯基等。对于“任选取代的环烯基”的取代基与对于上述的“环烷基”的取代基相同。
作为“任选取代的氨基”的示例性取代基有任选取代的低级烷基{其中所述取代基为低级烷氧基、环烷基、任选取代的氨基(其中所述取代基为由酰氧基(低级)烷氧基任选取代的芳酰基)、任选取代的芳基(其中所述取代基为低级烷基、低级烷氧基、羧基或低级烷氧基羰基)或杂环}、低级链烯基、低级链炔基、环烷基、由低级烷基、羧基、酰基、低级烷氧基羰基任选取代的芳基、由低级烷基任选取代的氨磺酰基、任选取代的低级烷氧基羰基(所述取代基为卤素、酰氧基、由羟基取代的酰氧基、由羧基取代的酰氧基或杂环基羰基氧基等)、低级烷基磺酰基等。
术语“任选取代的氨基甲酰基”包括由低级烷基、低级链烯基、低级链炔基等任选取代的氨基甲酰基。
术语“任选取代的氨磺酰基”包括由低级烷基、低级链烯基、低级链炔基等任选取代的氨磺酰基。
术语“芳族碳环”包括苯环、萘环、蒽环、菲环、茚环等，优选苯环。
术语“芳基”包括苯基、萘基、蒽基、菲基、茚基等，优选苯基。
作为“任选取代的芳族碳环”和“任选取代的芳基”的示例性取代基有卤素、羟基、由卤素或羧基任选取代的低级烷基、由卤素、芳基、杂芳基或低级烷氧基任选取代的低级烷氧基、低级链烯基、低级链炔基、环烷基、低级链烯基氧基、低级链炔基氧基、环烷氧基、酰基、酰氧基、羧基、低级烷氧基羰基、低级链烯基氧基羰基、低级烷硫基、低级链炔基硫基、由低级烷基、环烷基(低级)烷基、杂芳基(低级)烷基、低级链烯基、环烷基、由卤素、低级烷氧基羰基或低级烷基磺酰基任选取代的酰基任选取代的氨基、胍基、硝基、低级烷基磺酰基、二羟基硼烷、由卤素任选取代的低级烷基磺酰基氧基、芳基磺酰基、芳基磺酰基氧基、芳基、5-或6-元杂环等。芳族碳环和芳基可以在一个或多个任何可能的位置上由这些取代基取代。优选的实例为卤素、羟基、由卤素任选取代的低级烷基、由芳基或低级烷氧基任选取代的低级烷氧基、低级链烯基氧基、酰氧基、低级烷硫基、由低级烷基、低级链烯基、由卤素任选取代的酰基或低级烷基磺酰基任选取代的氨基、硝基、低级烷基磺酰基、由卤素任选取代的低级烷基磺酰基氧基，或芳基磺酰基。
“芳基磺酰基”和“芳基磺酰基氧基”的芳基部分与上述“芳基”相同，优选苯基。对于“任选取代的芳基磺酰基”的取代基与上述“任选取代的芳基”的取代基相同，优选未取代的芳基磺酰基。
术语“5-或6-元杂环”包括含有至少一个任意选自O、S和N的杂原子的5-或6-元杂环。杂环的实例包括芳族杂环如吡咯环、咪唑环、吡唑环、吡啶环如4-吡啶基、哒嗪环、嘧啶环、吡嗪环、三唑环、三嗪环、异噁唑环、噁唑环、噁二唑环、异噻唑环、噻唑环、噻二唑环、呋喃环如2-呋喃基或3-呋喃基、噻吩环如3-噻吩基等，脂族杂环如四氢吡喃环、二氢吡啶环如1,2-二氢吡啶基、二氢哒嗪如2,3-二氢哒嗪基、二氢吡嗪环如1,2-二氢吡嗪基、二噁烷环、oxathiorane环、thiane环、吡咯烷环、吡咯啉环、咪唑烷环、咪唑啉环、吡唑烷环、吡唑啉环、哌啶环、哌嗪环、吗啉环等。
在上述“5-或6-元杂环”中术语“含有一个或两个杂原子的5-或6-元杂环”包括芳族杂环如吡咯环、咪唑环、吡唑环、吡啶环、哒嗪环、嘧啶环、吡嗪环、异噁唑环、噁唑环、异噻唑环、噻唑环、呋喃环、噻吩环等以及脂族杂环如二噁烷环、oxathiorane环、thiane环、二氢吡啶环、吡咯烷环、吡咯啉环、咪唑烷环、咪唑啉环、吡唑烷环、吡唑啉环、哌啶环、哌嗪环、吗啉环等，优选芳族杂环。
“可与苯环稠合的5-或6-元环”的示例有吲哚环、异吲哚环、苯并咪唑环、吲唑环、噌啉环、2,3-二氮杂萘环、喹唑啉环、苯并异噁唑环、苯并噁唑环、苯并噁二唑环、苯并噻唑环、苯并异噻唑环、苯并呋喃环、苯并噻吩环、苯并三唑环、异苯并呋喃环、苯并吡喃环、二氢吲哚环、二氢异吲哚环等。
作为“任选取代的5-或6-元杂环”和“可与苯环稠合的任选取代的5-或6-元杂环”的示例性取代基有卤素、羟基、由羟基或酰氧基任选取代的低级烷基、由卤素、芳基或5-或6-元杂环任选取代的低级烷氧基、低级链烯基、低级链烯基氧基、低级链炔基、低级链炔基氧基、酰氧基、羧基、低级烷氧基羰基、巯基、低级烷硫基、低级链烯基硫基、可以由卤素、任选取代的低级烷基(其中所述取代基为环烷基或5-或6-元杂环)、由卤素、低级链烯基、环烷基或低级烷基磺酰基任选取代的酰基一取代或二取代的氨基、由低级烷基磺酰基任选取代的亚氨基、硝基、低级烷基磺酰基、芳基、5-或6-元杂环、氧代、氧化物等。这些取代基可在一个或多个任何可能的位置上被取代。
对于“含有一个或两个杂原子的任选取代的5-或6-元杂环”的取代基与上述的相同。优选由低级烷基取代的5-或6-元杂环或未取代的5-或6-元杂环。
术语“当A环、B环和/或C环为任选取代的5-元杂环时，W1、W2和/或W3表示键”意思如下：当A环为任选取代的5-元杂环时，W1表示键，产生如下所示的V1和X键合于A环上的位置：当B环或C环为5-元杂环时，W2和W3各自表示键，产生如下所示的V1和V2的键合位置：
Figure 9980434500222
X、V1和V2可各自直接连接于构成A环、B环或C环的杂原子上。
术语“化合物(Ⅰ)”包括每种化合物可形成的且药学上可接受的盐。作为“药学上可接受的盐”的示例有与无机酸如盐酸、硫酸、硝酸、磷酸、氢氟酸、氢溴酸等的盐，与有机酸如甲酸、乙酸、酒石酸、乳酸、柠檬酸、富马酸、马来酸、琥珀酸等的盐，与有机碱的盐如铵盐、三甲基铵盐、三乙基铵盐等，与碱金属如钠、钾等的盐以及与碱土金属如钙、镁等的盐。
本发明化合物包括水合物及其所有的立体异构体，例如其阻转异构体等。
实施本发明的最好模式
所有的化合物(Ⅰ)均具有免疫抑制作用、抗过敏作用和/或对IgE产生的抑制作用，下列化合物是特别优选的。
在式(Ⅰ)中，1)其中A环是任选取代的苯环的化合物，优选A环是任选取代的苯环{其中所述取代基为卤素、羟基、低级烷基、低级烷氧基、酰氧基、低级烷基磺酰基、任选取代的低级烷基磺酰基氧基(其中所述取代基为卤素)或芳基磺酰基氧基}，更优选A环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基或低级烷基磺酰基氧基)，2)其中B环是任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的噻吩环、任选取代的呋喃环、任选取代的吡唑环或任选取代的噁唑环的化合物，优选B环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基、低级链烯基氧基、低级烷硫基、环烷氧基、低级烷氧基羰基或低级烷基磺酰基氧基)，任选取代的吡啶环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基、低级烷硫基、低级链烯基、氨基、羧基或低级烷氧基羰基)，任选取代的嘧啶环{其中所述取代基为卤素、任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、低级烷氧基、低级烷硫基、任选取代的氨基(其中所述取代基为低级烷基)、羧基或低级烷氧基羰基}，任选取代的哒嗪环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基、低级烷硫基、低级链烯基、氨基、羧基、低级烷氧基羰基或氧化物)，任选取代的噻吩环(其中所述取代基为低级烷基)，任选取代的吡唑环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基)、低级烷氧基、羧基或低级烷氧基羰基}，或任选取代的噁唑环(其中所述取代基为低级烷基)，更优选B环是任选取代的苯环(其中所述取代基为羟基、低级烷基、低级烷氧基或低级烷基磺酰基氧基)，任选取代的吡啶环(其中所述取代基为卤素或低级烷基)，任选取代的嘧啶环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、低级烷氧基、低级烷硫基、任选取代的氨基(其中所述取代基为低级烷基)、羧基或低级烷氧基羰基}，任选取代的吡唑环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基)、低级烷氧基、羧基或低级烷氧基羰基}，3)其中C环是任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的异噁唑环、任选取代的吡唑环、任选取代的苯并噻唑环、任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环、任选取代的三唑环、任选取代的二氢吡啶环、任选取代的二氢哒嗪环或任选取代的二氢吡嗪环，优选C环是任选取代的苯环{其中所述取代基为卤素、羟基、任选取代的低级烷基(其中所述取代基为卤素)、任选取代的低级烷氧基(其中所述取代基为芳基或低级烷氧基)、低级链烯基氧基、低级烷硫基、任选取代的氨基[其中所述取代基为低级烷基、低级链烯基、任选取代的酰基(其中所述取代基为卤素)或低级烷基磺酰基]、硝基、低级烷基磺酰基或低级烷基磺酰基氧基}的化合物，任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的异噁唑环、任选取代的吡唑环{其中所述取代基为卤素、羟基、任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、任选取代的低级烷氧基(其中所述取代基为卤素、芳基或5-或6-元杂环)、低级链烯基、低级链烯基氧基、低级链炔基、低级链炔基氧基、酰氧基、羧基、低级烷氧基羰基、巯基、低级烷硫基、低级链烯基硫基、任选一-或二-取代的氨基{其中所述取代基为卤素、任选取代的低级烷基(其中所述取代基为环烷基或5-或6-元杂环)、任选取代的酰基(其中所述取代基为卤素)、低级链烯基、环烷基或低级烷基磺酰基}、任选取代的亚氨基(其中所述取代基为低级烷基磺酰基)、硝基、低级烷基磺酰基、芳基、5-或6-元杂环、氧代或氧化物}，苯并噻唑环，任选取代的二氢吡啶(其中所述取代基为氧代)，任选取代的二氢哒嗪环(其中所述取代基为氧代)，任选取代的二氢吡嗪环(其中所述取代基为氧代)，更优选C环为任选取代的苯环{其中所述取代基为卤素、羟基、任选取代的低级烷基(其中所述取代基为卤素)、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、低级烷硫基、任选一-或二-取代的氨基{其中所述取代基为低级烷基、低级链烯基、任选取代的酰基(其中所述取代基为卤素)或低级烷基磺酰基]、硝基、低级烷基磺酰基或低级烷基磺酰基氧基}、任选取代的吡啶环{其中所述取代基为卤素、羟基、低级烷基、低级链烯基、低级链炔基、任选取代的低级烷氧基(其中所述取代基为卤素、芳基或5-或6-元杂环)、低级链烯基氧基、低级链炔基氧基、低级烷硫基、低级链烯基硫基、任选取代的氨基(其中所述取代基为低级烷基、杂环(低级)烷基、环烷基烷基、低级链烯基或环烷基)、低级烷基磺酰基、5-或6-元杂环、硝基或氧代}，任选取代的嘧啶环{其中所述取代基为卤素、羟基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基或低级链烯基)}，任选取代的哒嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基、低级烷氧基或低级链烯基)}，任选取代的吡嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级链烯基)}，4)其中X为-O-或-NR1-(其中R1为氢、甲基或异戊二烯基)，优选X为-O-、-NH-或-NMe-，更优选X为-O-或-NH-的化合物，5)其中Y为氢、任选取代的低级烷基、任选取代的低级链烯基、低级烷基磺酰基或任选取代的酰基，优选Y为任选取代的低级烷基、任选取代的低级链烯基、低级烷基磺酰基或任选取代的酰基，更优选Y为任选取代的低级烷基{其中所述取代基为5-或6-元杂环或任选取代的苯基(其中所述取代基为低级烷基或低级烷氧基)}或任选取代的低级链烯基(其中所述取代基为卤素)，最优选Y为甲基、任选取代的异戊二烯基(其中所述取代基为卤素)或任选取代的苄基(其中所述取代基为低级烷基或低级烷氧基)的化合物，6)其中X为-O-或-NH-和Y为任选取代的异戊二烯基(其中所述取代基为卤素)或任选取代的苄基(其中所述取代基为低级烷基或低级烷氧基)，或X为-NR1-和Y为甲基的化合物，优选-X-Y为-OCH2CH=CMe2-、-OBn、-OCH2C6H4-2-Me、-OCH2C6H4-3-Me、-OCH2C6H4-4-Me、-OCH2C6H4-4-OMe、-NMe2或-NHCH2CH=CMe2，更优选-X-Y为-OCH2CH=CMe2、-OBn或-NMe2，7)其中V1和V2之一为单键，而另一个为单键、-O-或-NH-，优选V1为单键和V2为单键、-O-或-NH-，最优选V1和V2均为单键的化合物，8)化合物，其中A环为任选取代的苯环，B环为任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的噻吩环、任选取代的呋喃环、任选取代的吡唑环或任选取代的噁唑环的化合物，C环是任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的异噁唑环、任选取代的吡唑环、任选取代的苯并噻唑环、任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环或任选取代的三唑环，X为-O-或-NR1-其中R1为氢、甲基或异戊二烯基，Y为任选取代的低级烷基或任选取代的低级链烯基，及V1和V2之一为单键，而另一个为单键、-O-或-NH-，优选A环是任选取代的苯环{其中所述取代基为卤素、羟基、低级烷氧基、酰氧基、低级烷基磺酰基、任选取代的低级烷基磺酰基氧基(其中所述取代基为卤素)或芳基磺酰基氧基}，B环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基、低级烷氧基羰基、低级链烯基氧基或低级烷基磺酰基氧基)，任选取代的吡啶环(其中所述取代基为卤素或低级烷基)，任选取代的嘧啶环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、低级烷氧基、低级烷硫基、任选取代的氨基(其中所述取代基为低级烷基)、羧基或低级烷氧基羰基)}，任选取代的哒嗪环(其中所述取代基为低级烷基或氧化物)，任选取代的噻吩环(其中所述取代基为低级烷基)，任选取代的吡唑环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基)、低级烷氧基、羧基或低级烷氧基羰基}，或任选取代的噁唑环(其中所述取代基为低级烷基)，C环是任选取代的苯环{其中所述取代基为卤素、羟基、任选取代的低级烷基(其中所述取代基为卤素)、任选取代的低级烷氧基(其中所述取代基为芳基或低级烷氧基)、低级链烯基氧基、低级烷硫基、任选取代的氨基{其中所述取代基为低级烷基、低级链烯基、任选取代的酰基(其中所述取代基为卤素)或低级烷基磺酰基}、硝基、低级烷基磺酰基或低级烷基磺酰基氧基}，任选取代的吡啶环{其中所述取代基为卤素、羟基、低级烷基、低级链烯基、低级链炔基、任选取代的低级烷氧基(其中所述取代基为卤素、芳基或5-或6-元杂环)、低级链烯基氧基、低级链炔基氧基、低级烷硫基、低级链烯基硫基、任选取代的氨基(其中所述取代基为低级烷基、杂环(低级)烷基、环烷基烷基、低级链烯基或环烷基)、低级烷基磺酰基、5-或6-元杂环、硝基或氧代}，任选取代的嘧啶环{其中所述取代基为卤素、羟基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基或低级链烯基)}，任选取代的哒嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基、低级烷氧基或低级链烯基)}，任选取代的吡嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、任选取代的氨基(其中所述取代基为低级链烯基)}，任选取代的异噁唑环{其中所述取代基为任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、任选取代的氨基(其中所述取代基为低级链烯基或低级烷基磺酰基)}，任选取代的吡唑环{其中所述取代基为低级烷基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级链烯基或低级烷基磺酰基)}，或苯并噻唑环，X为-O-、-NH-或-NMe-，Y为任选取代的低级烷基{其中所述取代基为5-或6-元杂环或任选取代的苯基(其中所述取代基为低级烷基或低级烷氧基)}或低级链烯基(其中所述取代基为卤素)，V1和V2之一为单键，而另一个为单键、-O-或-NH-，更优选A环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷氧基或低级烷基磺酰基氧基)，B环是苯环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基或低级烷氧基羰基)，任选取代的吡啶环(其中所述取代基为卤素或低级烷基)，任选取代的嘧啶环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、低级烷氧基、低级烷硫基、任选取代的氨基(其中所述取代基为低级烷基)、羧基或低级烷氧基羰基}，任选取代的吡唑环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基)、低级烷氧基、羧基或低级烷氧基羰基}，C环是任选取代的苯环{其中所述取代基为卤素、羟基、任选取代的低级烷基(其中所述取代基为卤素)、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、低级烷硫基、任选取代的氨基{其中所述取代基为低级烷基、低级链烯基、任选取代的酰基(其中所述取代基为卤素)或低级烷基磺酰基}、硝基、低级烷基磺酰基或低级烷基磺酰基氧基}，任选取代的吡啶环{其中所述取代基为卤素、羟基、低级烷基、低级链烯基、低级链炔基、任选取代的低级烷氧基(其中所述取代基为卤素、芳基或5-或6-元杂环)、低级链烯基氧基、低级链炔基氧基、低级烷硫基、低级链烯基硫基、任选取代的氨基(其中所述取代基为低级烷基、杂环(低级)烷基、环烷基烷基、低级链烯基或环烷基)，低级烷基磺酰基、5-或6-元杂环、硝基或氧代}，任选取代的嘧啶环{其中所述取代基为卤素、羟基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基或低级链烯基)}。任选取代的哒嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基、低级烷氧基或低级链烯基)}，或任选取代的吡嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级链烯基)}，X为-O-和Y为异戊二烯基或任选取代的苄基(其中所述取代基为低级烷基或低级烷氧基)或X为-NR1-和Y为甲基，V1为单键和V2为单键、-O-或-NH-，更优选A环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷氧基或低级烷基磺酰基氧基)，B环是任选取代的苯环(其中所述取代基为卤素、羟基、低级烷基、低级烷氧基或低级烷氧基羰基)，任选取代的吡啶环(其中所述取代基为低级烷基)，任选取代的嘧啶环(其中所述取代基为低级烷基、低级烷氧基、羧基或低级烷氧基羰基)，任选取代的吡唑环(其中所述取代基为低级烷基、低级烷氧基、羧基或低级烷氧基羰基)，C环是任选取代的苯环{其中所述取代基为卤素、羟基、低级烷氧基、低级链烯基氧基、任选取代的氨基(其中所述取代基为低级烷基)或低级烷基磺酰基氧基}，任选取代的吡啶环{其中所述取代基为任选取代的氨基{其中所述取代基为卤素、低级烷基、任选取代的低级烷氧基(其中所述取代基为芳基或5-或6-元杂环)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基、杂环基(低级)烷基或低级链烯基)}，任选取代的嘧啶环(其中所述取代基为卤素、羟基、低级烷氧基、低级链烯基氧基、氨基或低级链烯基氨基)，任选取代的哒嗪环(其中所述取代基为卤素、低级烷氧基、低级链烯基氧基、氨基、低级烷基氨基或低级链烯基氨基)，或任选取代的吡嗪环(其中所述取代基为低级链烯基氧基、氨基或低级链烯基氨基)，X为-O-和Y为异戊二烯基或任选取代的苄基(其中所述取代基为低级烷基或低级烷氧基)或X为NR1和Y为甲基或异戊二烯基，V1为单键和V2为单键、-O-或-NH-，9)其中A环、B环和C环中的两个为任选取代的苯环而另一个为可与苯环稠合的任选取代的5-或6-元杂环，优选A环是任选取代的苯环，B环和C环之一是任选取代的苯环而另一个是可与苯环稠合的任选取代的5-或6-元杂环，更优选A环是任选取代的苯环，B环和C环之一是任选取代的苯环而另一个是可与苯环稠合的任选取代的5-或6-元杂环且V1和V2均为单键的化合物，10)其中A环、B环和C环均为任选取代的苯环，V1为单键和V2为-O-或-NH-的化合物，11)其中A环和B环均为任选取代的苯环而-X-Y为-NMe2、异戊二烯基氧基或异戊二烯基氨基的化合物，优选A环和B环均为任选取代的苯环和C环为任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的异噁唑环或任选取代的吡唑环，-X-Y为-NMe2、异戊二烯基氧基或异戊二烯基氨基以及V1和V2均为单键，12)任何下式的化合物：
Figure 9980434500311
其中R4、R5、R6和R7各自独立为氢、卤素、羟基、低级烷氧基、酰氧基、任选取代的低级烷基磺酰基氧基(其中所述取代基为卤素)或芳基磺酰基氧基，R8、R9、R10和R11各自独立为氢、羟基、低级烷基、低级烷氧基或低级烷基磺酰基氧基，R12、R13、R14、R15和R16各自独立为氢、卤素、羟基、任选取代的低级烷基(其中所述取代基为卤素)、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、低级烷硫基、低级烷基磺酰基、低级烷基磺酰基氧基、硝基或任选取代的氨基{其中所述取代基为低级烷基、低级链烯基、任选取代的酰基(其中所述取代基为卤素)或低级烷基磺酰基}，B环是任选取代的吡啶环(其中所述取代基为卤素或低级烷基)，任选取代的嘧啶环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基或酰氧基)、低级烷氧基、低级烷硫基、任选取代的氨基(其中所述取代基为低级烷基)、羧基或低级烷氧基羰基}，任选取代的哒嗪(其中所述取代基为低级烷基或氧化物)，任选取代的噻吩环(其中所述取代基为低级烷基)，任选取代的吡唑环{其中所述取代基为任选取代的低级烷基(其中所述取代基为羟基)、低级烷氧基、羧基或低级烷氧基羰基}，或任选取代的噁唑环(其中所述取代基为低级烷基)，C环是任选取代的吡啶环{其中所述取代基为羟基、卤素、低级烷基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基、任选取代的氨基{其中所述取代基为低级烷基、任选取代的酰基(其中所述取代基为卤素)、低级链烯基或低级烷基磺酰基}、硝基、低级烷硫基、低级烷基磺酰基或任选取代的亚氨基(其中所述取代基为低级烷基磺酰基)}，任选取代的嘧啶环{其中所述取代基为卤素、羟基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基或低级链烯基)}，任选取代的哒嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基、低级烷氧基、低级链烯基或低级链烯基氧基)}，任选取代的吡嗪环{其中所述取代基为卤素、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级烷基或低级链烯基)}，任选取代的异噁唑环{其中所述取代基为任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级链烯基或烷基磺酰基)}，任选取代的吡唑环{其中所述取代基为低级烷基、任选取代的低级烷氧基(其中所述取代基为芳基)、低级链烯基氧基或任选取代的氨基(其中所述取代基为低级链烯基或低级烷基磺酰基)}，苯并噻唑环，吗啉环，哌嗪环(其中所述取代基为低级烷基或苯基)，咪唑环，或三唑环，V1为单键或-O-，V2为单键、-O-、-NH-、-OCH2-、-CH2O-、-CH=CH-、-C≡C-、-CH(OEt)-，-CH(OH)-、-CO-、-NHCH2-或-NHCH(OH)-，X为-O-或-NR1-(其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基)，和Y为甲基、任选取代的异戊二烯基(其中所述取代基为卤素)或任选取代的苄基(其中所述取代基为低级烷基或低级烷氧基)，13)其中A环和B环均为任选取代的苯环而C环为Y为CH2CH=CMe2和V1和V2均为单键的化合物，14)其中A环和B环均为苯环，C环为X为-O-,Y为氢，V1和V2均为单键的化合物，15)其中A环和B环均为任选取代的苯环，而C环为X为-NH-和V1和V2均为单键的化合物。
另一优选的实施方案为，[1]下式(Ib’)的化合物
Ib’其中C环为含有一个或两个杂原子的任选取代的5-或6-元杂环，当C环是5-元杂环时，W3表示键，X和X’各自独立为-O-、-CH2-、-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基或-S(O)p-，其中p为0-2的整数，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的酰基、任选取代的环烷基、任选取代的环烯基、任选取代的低级烷氧基羰基、任选取代的氨基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR')、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR'-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R8、R9、R10和R11各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的环烷基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、任选取代的氨基甲酰基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，排除其中R8、R9、R10和R11都选自氢和卤素的化合物。
在式(Ib’)的下列化合物中，优选的是：其中R4和R5各自独立为氢、羟基、卤素、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的酰氧基、任选取代的低级烷基磺酰基氧基或任选取代的芳基磺酰基氧基的化合物(下文称作“R4和R5为R45-1”)，其中R4和R5各自独立为氢、羟基、卤素、低级烷基、低级烷氧基、酰氧基、任选取代的低级烷基磺酰基氧基或芳基磺酰基氧基的化合物(下文称作“R4和R5为R45-2”)，其中R4和R5各自独立为氢、卤素或低级烷氧基的化合物(下文称作“R4和R5为R45-3”)，其中R4和R5之一为氢，而另一个为卤素的化合物(下文称作“R4和R5为R45-4”)，其中R4和R5之一为氢，而另一个为氯代或氟代的化合物(下文称作“R4和R5为R45-5”)，其中R4为氢和R5为卤素的化合物(下文称作“R4和R5为R45-6”)，其中R4为氢和R5为氯代或氟代的化合物(下文称作“R4和R5为R45-7”)，其中R6和R7各自独立为氢、卤素或低级烷基的化合物(下文称作“R6和R7为R67-1”)，其中R6和R7均为氢的化合物(下文称作“R6和R7为R67-2”)，其中R8和R11各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的环烷氧基、任选取代的低级烷硫基、任选取代的低级烷氧基羰基或任选取代的低级烷基磺酰基氧基的化合物(下文称作“R8和R11为R811-1”)，其中R8和R11各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的环烷氧基、任选取代的低级烷硫基、任选取代的低级烷氧基羰基或任选取代的低级烷基磺酰基氧基的化合物(下文称作“R8和R11为R811-2”)，其中R8和R11各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基或任选取代的低级烷氧基羰基的化合物(下文称作“R8和R11为R811-3”)，其中R8和R11各自独立为氢、卤素、任选取代的低级烷基、任选取代的低级烷氧基或低级烷氧基碳基的化合物(下文称作“R8和R11为R811-4”)，其中R8和R11各自独立为氢、任选取代的低级烷基、任选取代的低级烷氧基或低级烷氧基羰基的化合物(下文称作“R8和R11为R811-5”)，其中R8和R11各自独立为氢、任选取代的低级烷基或任选取代的低级烷氧基的化合物(下文称作“R8和R11为R811-6”)，其中R8和R11各自独立为任选取代的低级烷基或任选取代的低级烷氧基的化合物(下文称作“R8和R11为R811-7”)，其中R8和R11各自独立为低级烷基或低级烷氧基的化合物(下文称作“R8和R11为R811-8”)，其中R8和R11均为任选取代的低级烷基或任选取代的低级烷氧基的化合物(下文称作“R8和R11为R811-9”)，其中R8和R11均为低级烷基，或R8和R11之一为低级烷基而另一个为低级烷氧基的化合物(下文称作“R8和R11为R811-10”)，其中R8和R11均为低级烷基的化合物(下文称作“R8和R11为R811-11”)，其中R8和R11各自独立为甲基或甲氧基的化合物(下文称作“R8和R11为R811-12”)，其中R9和R10各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的环烷氧基、任选取代的低级烷硫基、任选取代的低级烷氧基羰基或任选取代的低级烷基磺酰基氧基的化合物(下文称作“R9和R10为R910-1”)，其中R9和R10各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、环烷氧基、低级烷硫基、低级烷氧基羰基或任选取代的低级烷基磺酰基氧基的化合物(下文称作“R9和R10为R910-2”)，其中R9和R10各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基或任选取代的低级烷基磺酰基氧基的化合物(下文称作“R9和R10为R910-3”)，其中R9和R10各自独立为氢、卤素、羟基、任选取代的低级烷基或任选取代的低级烷氧基的化合物(下文称作“R9和R10为R910-4”)，其中R9和R10各自独立为氢、任选取代的低级烷基或任选取代的低级烷氧基的化合物(下文称作“R9和R10为R910-5”)，其中R9和R10各自独立为氢或任选取代的低级烷基的化合物(下文称作“R9和R10为R910-6”)，其中R9和R10均为氢或任选取代的低级烷基的化合物(下文称作“R9和R10为R910-7”)，其中R9和R10均为氢或低级烷基的化合物(下文称作“R9和R10为R910-8”)，其中R9和R10均为氢的化合物(下文称作“R9和R10为R910-9”)，其中R9和R10均为低级烷基的化合物(下文称作“R9和R10为R910-10”)，其中R9和R10各自独立为氢或低级烷基的化合物(下文称作“R9和R10为R910-11”)，其中C环为含有至少一个N原子的5-或6-元杂环的化合物(下文称作“C环为C-1”)，其中C环为含有至少一个N原子的6-元杂环的化合物(下文称作“C环为C-2”)，其中C环为任选取代的吡啶、任选取代的嘧啶、任选取代的哒嗪或任选取代的吡嗪的化合物(下文称作“C环为C-3”)，其中C环为任选取代的吡啶或任选取代的嘧啶的化合物(下文称作“C环为C-4”)，其中C环为
Figure 9980434500391
其中G1为CR13或N,G2为CR15或N,R12、R13、R14和R15各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基碳基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基的化合物(下文称作“C环为C-5”)，其中C环为
Figure 9980434500392
其中G1为CR13或N,G2为CR15或N,R12、R13、R14和R15各自独立为氢、卤素、羟基、低级烷基、任选取代的低级链烯基、任选取代的低级烷氧基、任选取代的氨基或硝基的化合物(下文称作“C环为C-6”)，其中C环为C-5,G1和G2各自独立为CH或N的化合物(下文称作“C环为C-7”)，其中C环为C-6,G1和G2各自独立为CH或N的化合物(下文称作“C环为C-8”)，其中C环为
Figure 9980434500393
的化合物(下文称作“C环为C-9”)，其中X和X’为-O-、-CH2-、-NR1-(其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基)或-S(O)p-，其中p为0-2的整数，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的环烯基、任选取代的氨基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环，当X为-O-或-NR1-时，Y可以是任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可以是任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可以是氢或卤素，当X’为-CH2-或-NR1-时，Y’可以是氢或卤素，条件是Y和Y’不同时为氢的化合物(下文称作“X、X’、Y和Y’为XY-1”)，其中X和X’各自独立为-O-、-CH2-、-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基或-S(O)p-，其中p为0-2的整数，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-2”)，其中X和X’之一为-O-，而另一个为-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基的化合物(下文称作“X、X’、Y和Y’为XY-3”)，其中X和X’之一为-O-，而另一个为-NH-的化合物(下文称作“X、X’、Y和Y’为XY-4”)，其中Y和Y’中至少一个为异戊二烯基的化合物(下文称作“X、X’、Y和Y’为XY-5”)，其中X和X’各自独立为-O-或-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-6”)，其中X和X’之一为-O-而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基的化合物(下文称作“X、X’、Y和Y’为XY-7”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-8”)，其中X和X’之一为-O-而另一个为-NR1-，其中R1为氢、低级烷基或低级链烯基，Y和Y’各自独立为任选取代的低级烷基或任选取代的低级链烯基的化合物(下文称作“X、X’、Y和Y’为XY-9”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’各自独立为任选取代的低级烷基或任选取代的低级链烯基的化合物(下文称作“X、X’、Y和Y’为XY-10”)，其中X和X’之一为-O-而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’之一为低级烷基或低级链烯基而另一个为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-11”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’之一为低级烷基或低级链烯基而另一个为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-12”)，其中X和X’之一为-O-而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’之一为低级烷基或低级链烯基而另一个为氢或任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基的化合物(下文称作“X、X’、Y和Y’为XY-13”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’之一为低级烷基或低级链烯基而另一个为氢、任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基的化合物(下文称作“X、X’、Y和Y’为XY-14”)，其中X和X’为-O-而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’之一为异戊二烯基而另一个为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-15”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’之一为异戊二烯基而另一个为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的环烷基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环的化合物(下文称作“X、X’、Y和Y’为XY-16”)，其中X和X’之一为-O-而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或任选取代的低级烷氧基羰基，Y和Y’之一为异戊二烯基而另一个为氢、任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基的化合物(下文称作“X、X’、Y和Y’为XY-17”)，其中X和X’之一为-O-而另一个为-NH-,Y和Y’之一为异戊二烯基而另一个为氢、任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基的化合物(下文称作“X、X’、Y和Y’为XY-18”)，其中-X-Y和-X’-Y’中之一为任选取代的低级烷基氨基或任选取代的低级链烯基氨基，而另一个为任选取代的低级烷氧基或任选取代的低级链烯基氧基的化合物(下文称作“X、X’、Y和Y’为XY-19”)，其中-X-Y和-X’-Y’中之一为任选取代的低级烷基氨基或任选取代的低级链烯基氨基，而另一个为异戊二烯基氧基的化合物(下文称作“X、X’、Y和Y’为XY-20”)，其中R4和R5为R45-1且R6和R7为R67-1的化合物，其中R4和R5为R45-1且R6和R7为R67-2的化合物，其中R4和R5为R45-2且R6和R7为R67-1的化合物，其中R4和R5为R45-2且R6和R7为R67-2的化合物，其中R4和R5为R45-3且R6和R7为R67-1的化合物，其中R4和R5为R45-3且R6和R7为R67-2的化合物，其中R4和R5为R45-4且R6和R7为R67-1的化合物，其中R4和R5为R45-4且R6和R7为R67-2的化合物，其中R4和R5为R45-5且R6和R7为R67-1的化合物，其中R4和R5为R45-5且R6和R7为R67-2的化合物，其中R4和R5为R45-6且R6和R7为R67-1的化合物，其中R4和R5为R45-6且R6和R7为R67-2的化合物，其中R4和R5为R45-7且R6和R7为R67-1的化合物，其中R4和R5为R45-7且R6和R7为R67-2的化合物，其中R8和R11为R811-2且R9和R10为R910-3的化合物，其中R8和R11为R811-2且R9和R10为R910-4的化合物，其中R8和R11为R811-2且R9和R10为R910-5的化合物，其中R8和R11为R811-2且R9和R10为R910-6的化合物，其中R8和R11为R811-2且R9和R10为R910-7的化合物，其中R8和R11为R811-2且R9和R10为R910-8的化合物，其中R8和R11为R811-2且R9和R10为R910-9的化合物，其中R8和R11为R811-2且R9和R10为R910-10的化合物，其中R8和R11为R811-2且R9和R10为R910-11的化合物，其中R8和R11为R811-3且R9和R10为R910-3的化合物，其中R8和R11为R811-3且R9和R10为R910-4的化合物，其中R8和R11为R811-3且R9和R10为R910-5的化合物，其中R8和R11为R811-3且R9和R10为R910-6的化合物，其中R8和R11为R811-3且R9和R10为R910-7的化合物，其中R8和R11为R811-3且R9和R10为R910-8的化合物，其中R8和R11为R811-3且R9和R10为R910-9的化合物，其中R8和R11为R811-3且R9和R10为R910-10的化合物，其中R8和R11为R811-3且R9和R10为R910-11的化合物，其中R8和R11为R811-4且R9和R10为R910-3的化合物，其中R8和R11为R811-4且R9和R10为R910-4的化合物，其中R8和R11为R811-4且R9和R10为R910-5的化合物，其中R8和R11为R811-4且R9和R10为R910-6的化合物，其中R8和R11为R811-4且R9和R10为R910-7的化合物，其中R8和R11为R811-4且R9和R10为R910-8的化合物，其中R8和R11为R811-4且R9和R10为R910-9的化合物，其中R8和R11为R811-4且R9和R10为R910-10的化合物，其中R8和R11为R811-4且R9和R10为R910-11的化合物，其中R8和R11为R811-5且R9和R10为R910-1的化合物，其中R8和R11为R811-5且R9和R10为R910-2的化合物，其中R8和R11为R811-5且R9和R10为R910-3的化合物，其中R8和R11为R811-5且R9和R10为R910-4的化合物，其中R8和R11为R811-5且R9和R10为R910-5的化合物，其中R8和R11为R811-5且R9和R10为R910-6的化合物，其中R8和R11为R811-5且R9和R10为R910-7的化合物，其中R8和R11为R811-5且R9和R10为R910-8的化合物，其中R8和R11为R811-5且R9和R10为R910-9的化合物，其中R8和R11为R811-5且R9和R10为R910-10的化合物，其中R8和R11为R811-5且R9和R10为R910-11的化合物，其中R8和R11为R811-6且R9和R10为R910-1的化合物，其中R8和R11为R811-6且R9和R10为R910-2的化合物，其中R8和R11为R811-6且R9和R10为R910-3的化合物，其中R8和R11为R811-6且R9和R10为R910-4的化合物，其中R8和R11为R811-6且R9和R10为R910-5的化合物，其中R8和R11为R811-6且R9和R10为R910-6的化合物，其中R8和R11为R811-6且R9和R10为R910-7的化合物，其中R8和R11为R811-6且R9和R10为R910-8的化合物，其中R8和R11为R811-6且R9和R10为R910-9的化合物，其中R8和R11为R811-6且R9和R10为R910-10的化合物，其中R8和R11为R811-6且R9和R10为R910-11的化合物，其中R8和R11为R811-7且R9和R10为R910-1的化合物，其中R8和R11为R811-7且R9和R10为R910-2的化合物，其中R8和R11为R811-7且R9和R10为R910-3的化合物，其中R8和R11为R811-7且R9和R10为R910-4的化合物，其中R8和R11为R811-7且R9和R10为R910-5的化合物，其中R8和R11为R811-7且R9和R10为R910-6的化合物，其中R8和R11为R811-7且R9和R10为R910-7的化合物，其中R8和R11为R811-7且R9和R10为R910-8的化合物，其中R8和R11为R811-7且R9和R10为R910-9的化合物，其中R8和R11为R811-7且R9和R10为R910-10的化合物，其中R8和R11为R811-7且R9和R10为R910-11的化合物，其中R8和R11为R811-8且R9和R10为R910-1的化合物，其中R8和R11为R811-8且R9和R10为R910-2的化合物，其中R8和R11为R811-8且R9和R10为R910-3的化合物，其中R8和R11为R811-8且R9和R10为R910-4的化合物，其中R8和R11为R811-8且R9和R10为R910-5的化合物，其中R8和R11为R811-8且R9和R10为R910-6的化合物，其中R8和R11为R811-8且R9和R10为R910-7的化合物，其中R8和R11为R811-8且R9和R10为R910-8的化合物，其中R8和R11为R811-8且R9和R10为R910-9的化合物，其中R8和R11为R811-8且R9和R10为R910-10的化合物，其中R8和R11为R811-8且R9和R10为R910-11的化合物，其中R8和R11为R811-9且R9和R10为R910-1的化合物，其中R8和R11为R811-9且R9和R10为R910-2的化合物，其中R8和R11为R811-9且R9和R10为R910-3的化合物，其中R8和R11为R811-9且R9和R10为R910-4的化合物，其中R8和R11为R811-9且R9和R10为R910-5的化合物，其中R8和R11为R811-9且R9和R10为R910-6的化合物，其中R8和R11为R811-9且R9和R10为R910-7的化合物，其中R8和R11为R811-9且R9和R10为R910-8的化合物，其中R8和R11为R811-9且R9和R10为R910-9的化合物，其中R8和R11为R811-9且R9和R10为R910-10的化合物，其中R8和R11为R811-9且R9和R10为R910-11的化合物，其中R8和R11为R811-10且R9和R10为R910-1的化合物，其中R8和R11为R811-10且R9和R10为R910-2的化合物，其中R8和R11为R811-10且R9和R10为R910-3的化合物，其中R8和R11为R811-10且R9和R10为R910-4的化合物，其中R8和R11为R811-10且R9和R10为R910-5的化合物，其中R8和R11为R811-10且R9和R10为R910-6的化合物，其中R8和R11为R811-10且R9和R10为R910-7的化合物，其中R8和R11为R811-10且R9和R10为R910-8的化合物，其中R8和R11为R811-10且R9和R10为R910-9的化合物，其中R8和R11为R811-10且R9和R10为R910-10的化合物，其中R8和R11为R811-10且R9和R10为R910-11的化合物，其中R8和R11为R811-11且R9和R10为R910-1的化合物，其中R8和R11为R811-11且R9和R10为R910-2的化合物，其中R8和R11为R811-11且R9和R10为R910-3的化合物，其中R8和R11为R811-11且R9和R10为R910-4的化合物，其中R8和R11为R811-11且R9和R10为R910-5的化合物，其中R8和R11为R811-11且R9和R10为R910-6的化合物，其中R8和R11为R811-11且R9和R10为R910-7的化合物，其中R8和R11为R811-11且R9和R10为R910-8的化合物，其中R8和R11为R811-11且R9和R10为R910-9的化合物，其中R8和R11为R811-11且R9和R10为R910-10的化合物，其中R8和R11为R811-11且R9和R10为R910-11的化合物，其中R8和R11为R811-12且R9和R10为R910-1的化合物，其中R8和R11为R811-12且R9和R10为R910-2的化合物，其中R8和R11为R811-12且R9和R10为R910-3的化合物，其中R8和R11为R811-12且R9和R10为R910-4的化合物，其中R8和R11为R811-12且R9和R10为R910-5的化合物，其中R8和R11为R811-12且R9和R10为R910-6的化合物，其中R8和R11为R811-12且R9和R10为R910-7的化合物，其中R8和R11为R811-12且R9和R10为R910-8的化合物，其中R8和R11为R811-12且R9和R10为R910-9的化合物，其中R8和R11为R811-12且R9和R10为R910-10的化合物，其中R8和R11为R811-12且R9和R10为R910-1 1的化合物，其中R8和R5为R45-1且R8和R11为R811-3的化合物，其中R8和R5为R45-1且R8和R11为R811-4的化合物，其中R4和R5为R45-1且R8和R11为R811-5的化合物，其中R4和R5为R45-1且R8和R11为R811-6的化合物，其中R4和R5为R45-1且R8和R11为R811-7的化合物，其中R4和R5为R45-1且R8和R11为R811-8的化合物，其中R4和R5为R45-1且R8和R11为R811-9的化合物，其中R4和R5为R45-1且R8和R11为R811-10的化合物，其中R4和R5为R45-1且R8和R11为R811-11的化合物，其中R4和R5为R45-1且R8和R11为R811-12的化合物，其中R4和R5为R45-2且R8和R11为R811-3的化合物，其中R4和R5为R45-2且R8和R11为R811-4的化合物，其中R4和R5为R45-2且R8和R11为R811-5的化合物，其中R4和R5为R45-2且R8和R11为R811-6的化合物，其中R4和R5为R45-2且R8和R11为R811-7的化合物，其中R4和R5为R45-2且R8和R11为R811-8的化合物，其中R4和R5为R45-2且R8和R11R811-9的化合物，其中R4和R5为R45-2且R8和R11为R811-10的化合物，其中R4和R5为R45-2且R8和R11为R811-11的化合物，其中R4和R5为R45-2且R8和R11为R811-12的化合物，其中R4和R5为R45-3且R8和R11为R811-1的化合物，其中R4和R5为R45-3且R8和R11为R811-2的化合物，其中R4和R5为R45-3且R8和R11为R811-3的化合物，其中R4和R5为R45-3且R8和R11为R811-4的化合物，其中R4和R5为R45-3且R8和R11为R811-5的化合物，其中R4和R5为R45-3且R8和R11为R811-6的化合物，其中R4和R5为R45-3且R8和R11为R811-7的化合物，其中R4和R5为R45-3且R8和R11为R811-8的化合物，其中R4和R5为R45-3且R8和R11为R811-9的化合物，其中R4和R5为R45-3且R8和R11为R811-10的化合物，其中R4和R5为R45-3且R8和R11为R811-11的化合物，其中R4和R5为R45-3且R8和R11为R811-12的化合物，其中R4和R5为R45-4且R8和R11为R811-1的化合物，其中R4和R5为R45-4且R8和R11为R811-2的化合物，其中R4和R5为R45-4且R8和R11为R811-3的化合物，其中R4和R5为R45-4且R8和R11为R811-4的化合物，其中R4和R5为R45-4且R8和R11为R811-5的化合物，其中R4和R5为R45-4且R8和R11为R811-6的化合物，其中R4和R5为R45-4且R8和R11为R811-7的化合物，其中R4和R5为R45-4且R8和R11为R811-8的化合物，其中R4和R5为R45-4且R8和R11为R811-9的化合物，其中R4和R5为R45-4且R8和R11为R811-10的化合物，其中R4和R5为R45-4且R8和R11为R811-11的化合物，其中R4和R5为R45-4且R8和R11为R811-12的化合物，其中R4和R5为R45-5且R8和R11为R811-1的化合物，其中R4和R5为R45-5且R8和R11为R811-2的化合物，其中R4和R5为R45-5且R8和R11为R811-3的化合物，其中R4和R5为R45-5且R8和R11为R811-4的化合物，其中R4和R5为R45-5且R8和R11为R811-5的化合物，其中R4和R5为R45-5且R8和R11为R811-6的化合物，其中R4和R5为R45-5且R8和R11为R811-7的化合物，其中R4和R5为R45-5且R8和R11为R811-8的化合物，其中R4和R5为R45-5且R8和R11为R811-9的化合物，其中R4和R5为R45-5且R8和R11为R811-10的化合物，其中R4和R5为R45-5且R8和R11为R811-11的化合物，其中R4和R5为R45-5且R8和R11为R811-12的化合物，其中R4和R5为R45-6且R8和R11为R811-1的化合物，其中R4和R5为R45-6且R8和R11为R811-2的化合物，其中R4和R5为R45-6且R8和R11为R811-3的化合物，其中R4和R5为R45-6且R8和R11为R811-4的化合物，其中R4和R5为R45-6且R8和R11为R811-5的化合物，其中R4和R5为R45-6且R8和R11为R811-6的化合物，其中R4和R5为R45-6且R8和R11为R811-7的化合物，其中R4和R5为R45-6且R8和R11为R811-8的化合物，其中R4和R5为R45-6且R8和R11为R811-9的化合物，其中R4和R5为R45-6且R8和R11为R811-10的化合物，其中R4和R5为R45-6且R8和R11为R811-11的化合物，其中R4和R5为R45-6且R8和R11为R811-12的化合物，其中R4和R5为R45-7且R8和R11为R811-1的化合物，其中R4和R5为R45-7且R8和R11为R811-2的化合物，其中R4和R5为R45-7且R8和R11为R811-3的化合物，其中R4和R5为R45-7且R8和R11为R811-4的化合物，其中R4和R5为R45-7且R8和R11为R811-5的化合物，其中R4和R5为R45-7且R8和R11为R811-6的化合物，其中R4和R5为R45-7且R8和R11为R811-7的化合物，其中R4和R5为R45-7且R8和R11为R811-8的化合物，其中R4和R5为R45-7且R8和R11为R811-9的化合物，其中R4和R5为R45-7且R8和R11为R811-10的化合物，其中R4和R5为R45-7且R8和R11为R811-11的化合物，其中R4和R5为R45-7且R8和R11为R811-12的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R4和R10为R910-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-8的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-5的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-8的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-8的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-5的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-8的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-3的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-8的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-3的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-4的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-5的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-8的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-3的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-8的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-3的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-4的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-5的化合物，其中R4和R5为R45-2,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-8的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-3的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-8的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-3的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-5的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-8的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-3的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-8的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-3的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-5的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-8的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-3的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-8的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-3的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-4的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-5的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-7且R9和R10为R910-8的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-3的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-8的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-3的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-4的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-5的化合物，其中R4和R5为R45-4,R6和R7为R67-1,R8和R11为R811-12且R9和R10为R910-8的化合物，
[1]中描述的化合物、其盐或水合物，其中X’为-O-、-NR1-或-S(O)p-和C环为含有一个或两个杂原子的任选取代的5-元杂环，其中R4和R5为R45-4和C环为C-1的化合物，其中R8和R11为R811-9,R9和R10为R910-7和C环为C-1的化合物，其中R4和R5为R45-4和C环为C-2的化合物，其中R8和R11为R811-9,R9和R10为R910-7和C环为C-2的化合物，其中R4和R5为R45-4和C环为C-4的化合物，其中R8和R11为R811-9,R9和R10为R910-7和C环为C-4的化合物，其中X、Y、X’和Y’为XY-3和C环为C-2的化合物，其中X、Y、X’和Y’为XY-3和C环为C-3的化合物，其中X、Y、X’和Y’为XY-3和C环为C-4的化合物，其中X、Y、X’和Y’为XY-3和C环为C-6的化合物，其中X、Y、X’和Y’为XY-3和C环为C-8的化合物，其中X、Y、X’和Y’为XY-3和C环为C-9的化合物，其中X、Y、X’和Y’为XY-4和C环为C-2的化合物，其中X、Y、X’和Y’为XY-4和C环为C-3的化合物，其中X、Y、X’和Y’为XY-4和C环为C-4的化合物，其中X、Y、X’和Y’为XY-4和C环为C-6的化合物，其中X、Y、X’和Y’为XY-4和C环为C-8的化合物，其中X、Y、X’和Y’为XY-4和C环为C-9的化合物，其中X、Y、X’和Y’为XY-5和C环为C-2的化合物，其中X、Y、X’和Y’为XY-5和C环为C-3的化合物，其中X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中X、Y、X’和Y’为XY-5和C环为C-8的化合物，其中X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中X、Y、X’和Y’为XY-6和C环为C-2的化合物，其中X、Y、X’和Y’为XY-6和C环为C-3的化合物，其中X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中X、Y、X’和Y’为XY-6和C环为C-8的化合物，其中X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中X、Y、X’和Y’为XY-7和C环为C-2的化合物，其中X、Y、X’和Y’为XY-7和C环为C-3的化合物，其中X、Y、X’和Y’为XY-7和C环为C-4的化合物，其中X、Y、X’和Y’为XY-7和C环为C-6的化合物，其中X、Y、X’和Y’为XY-7和C环为C-8的化合物，其中X、Y、X’和Y’为XY-7和C环为C-9的化合物，其中X、Y、X’和Y’为XY-8和C环为C-2的化合物，其中X、Y、X’和Y’为XY-8和C环为C-3的化合物，其中X、Y、X’和Y’为XY-8和C环为C-4的化合物，其中X、Y、X’和Y’为XY-8和C环为C-6的化合物，其中X、Y、X’和Y’为XY-8和C环为C-8的化合物，其中X、Y、X’和Y’为XY-8和C环为C-9的化合物，其中X、Y、X’和Y’为XY-9和C环为C-2的化合物，其中X、Y、X’和Y’为XY-9和C环为C-3的化合物，其中X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中X、Y、X’和Y’为XY-9和C环为C-8的化合物，其中X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中X、Y、X’和Y’为XY-10和C环为C-2的化合物，其中X、Y、X’和Y’为XY-10和C环为C-3的化合物，其中X、Y、X’和Y’为XY-10和C环为C-4的化合物，其中X、Y、X’和Y’为XY-10和C环为C-6化合物，其中X、Y、X’和Y’为XY-10和C环为C-8的化合物，其中X、Y、X’和Y’为XY-10和C环为C-9的化合物，其中X、Y、X’和Y’为XY-11和C环为C-2的化合物，其中X、Y、X’和Y’为XY-11和C环为C-3的化合物，其中X、Y、X’和Y’为XY-11和C环为C-4的化合物，其中X、Y、X’和Y’为XY-11和C环为C-6的化合物，其中X、Y、X’和Y’为XY-11和C环为C-8的化合物，其中X、Y、X’和Y’为XY-11和C环为C-9的化合物，其中X、Y、X’和Y’为XY-12和C环为C-2的化合物，其中X、Y、X’和Y’为XY-12和C环为C-3的化合物，其中X、Y、X’和Y’为XY-12和C环为C-4的化合物，其中X、Y、X’和Y’为XY-12和C环为C-6的化合物，其中X、Y、X’和Y’为XY-12和C环为C-8的化合物，其中X、Y、X’和Y’为XY-12和C环为C-9的化合物，其中X、Y、X’和Y’为XY-13和C环为C-2的化合物，其中X、Y、X’和Y’为XY-13和C环为C-3的化合物，其中X、Y、X’和Y’为XY-13和C环为C-4的化合物，其中X、Y、X’和Y’为XY-13和C环为C-6的化合物，其中X、Y、X’和Y’为XY-13和C环为C-8的化合物，其中X、Y、X’和Y’为XY-13和C环为C-9的化合物，其中X、Y、X’和Y’为XY-14和C环为C-2的化合物，其中X、Y、X’和Y’为XY-14和C环为C-3的化合物，其中X、Y、X’和Y’为XY-14和C环为C-4的化合物，其中X、Y、X’和Y’为XY-14和C环为C-6的化合物，其中X、Y、X’和Y’为XY-14和C环为C-8的化合物，其中X、Y、X’和Y’为XY-14和C环为C-9的化合物，其中X、Y、X’和Y’为XY-15和C环为C-2的化合物，其中X、Y、X’和Y’为XY-15和C环为C-3的化合物，其中X、Y、X’和Y’为XY-15和C环为C-4的化合物，其中X、Y、X’和Y’为XY-15和C环为C-6的化合物，其中X、Y、X’和Y’为XY-15和C环为C-8的化合物，其中X、Y、X’和Y’为XY-15和C环为C-9的化合物，其中X、Y、X’和Y’为XY-16和C环为C-2的化合物，其中X、Y、X’和Y’为XY-16和C环为C-3的化合物，其中X、Y、X’和Y’为XY-16和C环为C-4的化合物，其中X、Y、X’和Y’为XY-16和C环为C-6的化合物，其中X、Y、X’和Y’为XY-16和C环为C-8的化合物，其中X、Y、X’和Y’为XY-16和C环为C-9的化合物，其中X、Y、X’和Y’为XY-17和C环为C-2的化合物，其中X、Y、X’和Y’为XY-17和C环为C-3的化合物，其中X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中X、Y、X’和Y’为XY-17和C环为C-8的化合物，其中X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中X、Y、X’和Y’为XY-18和C环为C-2的化合物，其中X、Y、X’和Y’为XY-18和C环为C-3的化合物，其中X、Y、X’和Y’为XY-18和C环为C-4的化合物，其中X、Y、X’和Y’为XY-18和C环为C-6的化合物，其中X、Y、X’和Y’为XY-18和C环为C-8的化合物，其中X、Y、X’和Y’为XY-18和C环为C-9的化合物，其中X、Y、X’和Y’为XY-19和C环为C-2的化合物，其中X、Y、X’和Y’为XY-19和C环为C-3的化合物，其中X、Y、X’和Y’为XY-19和C环为C-4的化合物，其中X、Y、X’和Y’为XY-19和C环为C-6的化合物，其中X、Y、X’和Y’为XY-19和C环为C-8的化合物，其中X、Y、X’和Y’为XY-19和C环为C-9的化合物，其中X、Y、X’和Y’为XY-20和C环为C-2的化合物，其中X、Y、X’和Y’为XY-20和C环为C-3的化合物，其中X、Y、X’和Y’为XY-20和C环为C-4的化合物，其中X、Y、X’和Y’为XY-20和C环为C-6的化合物，其中X、Y、X’和Y’为XY-20和C环为C-8的化合物，其中X、Y、X’和Y’为XY-20和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R6为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-1 7和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R91 0-7,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R8114且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-4且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-5且R9和R10为R910-5,X、Y、X’和Y’为XY-7和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为 R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-8且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-4,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-20和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-20和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-5,X、Y、X’和Y’为XY-20和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-5和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y5为XY-5和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y5为XY-5和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y5为XY-6和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y5为XY-6和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y5为XY-6和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X5和Y’为XY-9和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-9和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-17和C环为C-9的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-20和C环为C-4的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-20和C环为C-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R8和R11为R811-10且R9和R10为R910-7,X、Y、X’和Y’为XY-20和C环为C-9的化合物，其中X’为-O-、-NR1-或-S(O)p-和C环为含有一个或两个杂原子的任选取代的5-元杂环的化合物，其中C环为吡啶环，-X-Y和-X’-Y’之一为1-吡咯烷基、1-哌啶基、4-吗啉基、4-硫代吗啉基、任选取代的1-哌啶基(piperadinyl)(其中所述取代基为低级烷基或低级链烯基)或任选取代的1-吡咯基(其中所述取代基为低级烷基)，而另一个为-NHCH2CH=CMe2、-OCH2CH=CMe2或-SCH2CH=CMe2的化合物，其中C环为吡啶环，-X-Y和-X’-Y’之一为1-吡咯烷基、任选取代的1-吡咯基(其中所述取代基为低级烷基)，而另一个为-NHCH2CH=CMe2、-OCH2CH=CMe2或-SCH2CH=CMe2的化合物。
本发明的另一个实施方案是[2]下式的化合物：
Figure 9980434500861
其中每个符号与上面[1]中的定义相同，[3]式(Ia’)的化合物、其盐或水合物：其中B环为含有一个或两个杂原子的任选取代的5-或6-元杂环(其中所述取代基为卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，其中B环仅被卤素取代的化合物不包括在内)，和当B环为5-元杂环时W2表示键，X、X’、Y和Y’如同在[1]中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR')、-CR'=CH-CH=CR'-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR'-(CH2)n-或-C(=O)-NR'-N=CH-，其中m是4或5,n是2或3，R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R12、R13、R14和R15各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的链烯基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、任选取代的氨基甲酰基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，排除：
(ⅰ)其中Y和Y’同时为氢的化合物，
(ⅱ)其中Y和Y’中至少一个为任选取代的酰基的化合物，
(ⅲ)其中-X-Y和-X’-Y’中至少一个为未取代的低级烷氧基的化合物，及
(ⅳ)其中-X-Y和-X’-Y’同时为任选取代的低级烷氧基或由苯基取代的氨基的化合物。
更优选下列式(Ia’)化合物、其盐或水合物：其中R4和R5为R45-1的化合物，其中R4和R5为R45-2的化合物，其中R4和R5为R45-3的化合物，其中R4和R5为R45-4的化合物，其中R4和R5为R45-5的化合物，其中R4和R5为R45-6的化合物，其中R4和R5为R45-7的化合物，其中R6和R7为R67-1的化合物，其中R6和R7为R67-2的化合物，其中B环为含有至少一个N原子的5-或6-元杂环的化合物(此后称作“B环为B-1”)，其中B环为含有至少一个N原子的6-元杂环的化合物(此后称作“B环为B-2”)，其中B环为任选取代的吡啶、任选取代的嘧啶、任选取代的哒嗪或任选取代的吡嗪的化合物(此后称作“B环为B-3”)，其中B环为任选取代的吡啶或任选取代的嘧啶的化合物(此后称作“B环为B-4”)，其中B环为任选取代的吡啶或任选取代的嘧啶(其中所述取代基为任选取代的低级烷基或任选取代的低级烷氧基)的化合物(此后称作“B环为B-5”)，其中B环为任选取代的吡啶的化合物(此后称作“B环为B-6”)，其中B环为，其中G为CH或N,R8和R11和各自独立为卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的酰氧基、羧基或任选取代的低级烷氧基羰基的化合物(此后称作“B环为B-7”)，其中R12、R13、R14和R15各自独立为氢、羟基、卤素、任选取代的低级烷氧基、任选取代的酰氧基、任选取代的低级烷基磺酰基氧基或任选取代的芳基磺酰基氧基的化合物(此后称作“R12、R13、R14、R15和R16为R12-15-1”)，其中R12、R13、R14和R15各自独立为氢、羟基、卤素、低级烷氧基、酰氧基、任选取代的低级烷基磺酰基氧基或芳基磺酰基氧基的化合物(此后称作“R12、R13、R14和R15为R12-15-2”)，其中R12、R13、R14和R15各自独立为氢、卤素或低级烷基的化合物(此后称作“R12、R13、R14和R15为R12-15-3”)，其中R12、R13、R14和R15各自独立为氢、氟代或氟代的化合物(此后称作“R12、R13、R14和R15为R12-15-4”)，其中X、Y、X’和Y为XY-1的化合物，其中X、Y、X’和Y为XY-2的化合物，其中X、Y、X’和Y为XY-3的化合物，其中X、Y、X’和Y为XY-4的化合物，其中X、Y、X’和Y为XY-5的化合物，其中X、Y、X’和Y为XY-6的化合物，其中X、Y、X’和Y为XY-7的化合物，其中X、Y、X’和Y为XY-8的化合物，其中X、Y、X’和Y为XY-9的化合物，其中X、Y、X’和Y为XY-10的化合物，其中X、Y、X’和Y为XY-11的化合物，其中X、Y、X’和Y为XY-12的化合物，其中X、Y、X’和Y为XY-13的化合物，其中X、Y、X’和Y为XY-14的化合物，其中X、Y、X’和Y为XY-15的化合物，其中X、Y、X’和Y为XY-16的化合物，其中X、Y、X’和Y为XY-17的化合物，其中X、Y、X’和Y为XY-18的化合物，其中X、Y、X’和Y为XY-19的化合物，其中X、Y、X’和Y为XY-20的化合物，其中R4和R5为R45-3且R6和R7为R67-2的化合物，其中R4和R5为R45-4且R6和R7为R67-2的化合物，其中R4和R5为R45-4且B环为B-1的化合物，其中R4和R5为R45-4且B环为B-2的化合物，其中R4和R5为R45-4且B环为B-4的化合物，其中R4和R5为R45-4且R12、R13、R14和R15为R12-15-3的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-1,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-4且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-2,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R5为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-5的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-7的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-3,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-3且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-3且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-5且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-5且X、X’、Y和Y’为XY-17的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-7且X、X’、Y和Y’为XY-6的化合物，其中R4和R5为R45-3,R6和R7为R67-1,R12、R13、R14和R15为R12-15-4,B环为B-7且X、X’、Y和Y’为XY-17的化合物，其中B环为B-7,X和X’各自独立为-O-、-NR1-(其中R1为氢、低级烷基、低级链烯基或低级烷基羰基)或-S(O)p-(其中p为0-2的整数)的化合物。
本发明的另一个实施方案是[4]式(If’)的化合物、其盐或水合物：
If’其中B环和C环之一为含有一个或两个杂原子的任选取代的5-或6-元杂环，而另一个为含有至少一个N原子的6-元杂环，其中B环的每一个取代基都选自氰基和卤素的化合物不包括在内，X、X’、Y、Y’和W3如同在[1]中的定义，W2如同在[3]中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6和R7如同在[1]中的定义。
优选属于化合物(If’)的下列化合物。其中B环为B-2的化合物，其中B环为B-3的化合物，其中B环为B-4的化合物，其中B环为B-5的化合物，其中B环为B-6的化合物，其中B环为可由低级烷基或低级烷氧基取代的吡啶的化合物，其中C环为C-1的化合物，其中C环为C-2的化合物，其中C环为任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环、任选取代的三唑环或任选取代的吡啶环的化合物，其中C环为任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环、任选取代的三唑环或任选取代的吡啶环(其中所述取代基为低级烷基、芳基或低级链烯基氧基)的化合物，其中R4、R5、R6和R7各自独立为氢、羟基或低级烷基磺酰基氧基的化合物，其中B环为可由低级烷基或低级烷氧基取代的吡啶环，C环为任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环、任选取代的三唑环或任选取代的吡啶环(其中所述取代基为低级烷基、芳基或低级链烯基氧基)，及R4、R5、R6和R7各自独立为氢、羟基或低级烷基磺酰基氧基的化合物。
本发明的另一个实施方案是[5]式(Ig’)的化合物、其盐或水合物：其中A环和C环各自独立为含有一个或两个杂原子的任选取代的5-或6-元环，当A环为5-元杂环时，W1为键X、X’、Y和Y’如同在[1]中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基碳基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R8、R9、R10和R11如同在[1]中的定义，其中R8、R9、R10和R11都选自氢和卤素的化合物不包括在内。
优选属于化合物(Ig’)的下列化合物或其盐或水合物。其中A环和C环中至少一个为6-元环的化合物，其中A环和C环中至少一个为含有N原子的6-元环的化合物，其中A环为任选取代的吡啶环的化合物，其中A环为未取代的吡啶环的化合物，其中R8、R9、R10和R11各自独立为氢、低级烷基或低级烷氧基的化合物，其中C环为任选取代的吡啶环、任选取代的嘧啶环或任选取代的吡嗪环的化合物，其中C环为未取代的吡啶环、未取代的嘧啶环或未取代的吡嗪环的化合物，其中-X-Y为低级链烯基氧基或低级链烯基氨基的化合物，其中-X’-Y’为可由低级链烯基取代的氨基的化合物，其中A环为未取代的吡啶环，R8、R9、R10和R11各自独立为氢、低级烷基或低级烷氧基的化合物，C环为未取代的吡啶环，未取代的嘧啶环或未取代的吡嗪环，-X-Y为低级链烯基氧基或低级链烯基氨基和-X’-Y’为可由低级链烯基取代的氨基的化合物。
本发明的其它优选实施方案如下。[6]用作免疫抑制剂的含有式(Ib’)化合物、其盐或水合物的药用组合物：
Figure 9980434500981
Ib’其中C环和W3如同在[1]中的定义，其中X和X’各自独立为-O-、-CH2-、-NR1-(其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基)、-S(O)p-(其中p为O-2的整数)或键，Y和Y’如同[1]中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，及R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为低级烷氧基，当X’为-CH2-时，Y’可为低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，当X’为键时，Y’可为氢、羟基、卤素、硝基或氧代，R4、R5、R6、R7、R8、R9、R10和R11如同在[1]中的定义，其中R8、R9、R10和R11都选自氢和卤素的化合物不包括在内。
[7]用作免疫抑制剂的含有式(Ia’)化合物、其盐或水合物的药用组合物：
Figure 9980434500991
Ia’其中B环为含有一个或两个杂原子的任选取代的5-或6-元杂环，其中B环的每一个取代基都选自氰基和卤素的化合物不包括在内，当B环为5-元杂环时，W2为键，X、X’、Y和Y’如同[3]中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，及R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R12、R13、R14和R15如同在[3]中的定义，排除
(ⅰ)其中-X-Y和-X’-Y’同时为未取代的低级烷基、任选取代的低级烷氧基或未取代的酰氧基的化合物，
(ⅱ)-X-Y和-X’-Y’中之一为甲基，而另一个为甲氧基的化合物，及
(ⅲ)其中-X’-Y’为氢或卤素和-X-Y为未取代的低级烷基、未取代的低级烷氧基或二(低级)烷基氨基的化合物。
[8]用作免疫抑制剂的含有[4]中所述的式(If’)化合物、其盐或水合物的药用组合物，
[9]用作免疫抑制剂的含有[5]中所述的化合物(Ig’)、其盐或水合物的药用组合物，
[10]用作抗过敏剂的含有[4]中所述的式(If’)化合物、[5]中所述的式(Ig’)化合物、[6]中所述的式(Ib’)化合物、[7]中所述的式(Ia’)化合物、其盐或水合物的药用组合物，
[11]用作IgE产生抑制剂的含有[4]中所述的式(If’)化合物、[5]中所述的式(Ig’)化合物、[6]中所述的式(Ib’)化合物、[7]中所述的式(Ia’)化合物、其盐或水合物的药用组合物，
[12][4]中所述的式(If’)化合物、[5]中所述的式(Ig’)化合物、[6]中所述的式(Ib’)化合物、[7]中所述的式(Ia’)化合物、其盐或水合物在制备用于抑制免疫应答、治疗和/或预防过敏性疾病的药物中的用途，
[13]抑制免疫应答或治疗和/或预防过敏性疾病的方法，该方法包括给予[4]中所述的式(If’)化合物、[5]中所述的式(Ig’)化合物、[6]中所述的式(Ib’)化合物、[7]中所述的式(Ia’)化合物、其盐或水合物，及
[14]治疗和/或预防过敏性疾病的方法，该方法包括给予[4]中所述的式(If’)化合物、[5]中所述的式(Ig’)化合物、[6]中所述的式(Ib’)化合物、[7]中所述的式(Ia’)化合物、其盐或水合物。
本发明的优选化合物为具有下列结构的化合物。表中的符号A2,A5,...B1,B4,...T1,T2...意义如下。
                                       表1
    R4  R5  R6  R7     X       Y
A2     H  H  H  H     O   CH2-2-呋喃基
A5     H  H  H  H     O    CH2CH=CMe2
A35    OMe  H  H  H     O    CH2CH=CMe2
A37     F  H  H  H     O    CH2CH=CMe2
A45     H  H  H  H     NH    CH2CH=CH2
A46     H  H  H  H     NH    CH2CH=CMe2
A49     H  H  H  H     NH    CH2-环己基
A54     H  H  H  H     NH   CH2-2-呋喃基
A66     H  F  H  H     NH     iBu
A67     H  F  H  H     NH   CH2CH=CMe2
A68     H  F  H  H     NH     环戊基
A69     H  F  H  H     NH     环己基
A70     H  F  H  H     NH   CH2环己基
A76     H  F  H  H    N-异丙基    SO2NHMe
A77     H  F  H  H  NCH2CH=CMe2    SO2NHMe
A78     F  H  H  H     NH   CH2CH=CMe2
A106     H  F  H  H     NH    CH2C6H5
A110     F  H  H  H     O    CH2C6H5
                              表2
Figure 9980434501021
   R8    R9    R10    R11
 B1  OMe     H     H    OMe
 B4   Me     H     H     Me
 B7   Me     Me     Me     Me
 B8   Me     Me    OMe     Me
 B9   Me     Me     OH     Me
 B10   Me     Me     Me    OMe
 B12  OMe     Me     Me    OMe
 B14   Me     Me     H     Me
 B16   Me     F     H     Me
 B17  OMe     H     H     Me
 B24   Me     Me     Me   COOMe
 B28   Me     Me     Me     Cl
 B29   Me    OMe     H     Me
 B30  COOMe     Me     Me     Me
 B31   Cl     Me     Me     Me
 B32   H     Me     Me     Cl
 B33   Me     H     Cl     Me
 B34   H     Me     Cl     H
 B35   Me     H     H     Cl
 B36   Me     Me     H     H
 B37   H     Me     H     Me
 B38   Me     H     Me     H
 B39  OMe    OMe     H     H
 B40   H    OMe     H    OMe
 B41  OMe     H    OMe     H
 B42   H     Me     H    OMe
 B43  OMe     H     Me     H
                     表3
Figure 9980434501031
表4
                                    表5
  T2-2     B1     A68     T2-3     B1     A68
  T2-2     B1     A69     T2-3     B1     A69
  T2-2     B1     A70     T2-3     B1     A70
  T2-2     B1     A76     T2-3     B1     A76
  T2-2     B1     A77     T2-3     B1     A77
  T2-2     B1     A78     T2-3     B1     A78
  T2-2     B1     A106     T2-3     B1     A106
  T2-2     B1     A110     T2-3     B1     A110
  T2-4     B1     A2     T2-5     B1     A2
  T2-4     B1     A5     T2-5     B1     A5
  T2-4     B1     A35     T2-5     B1     A35
  T2-4     B1     A37     T2-5     B1     A37
  T2-4     B1     A45     T2-5     B1     A45
  T2-4     B1     A46     T2-5     B1     A46
  T2-4     B1     A49     T2-5     B1     A49
  T2-4     B1     A54     T2-5     B1     A54
  T2-4     B1     A66     T2-5     B1     A66
  T2-4     B1     A67     T2-5     B1     A67
  T2-4     B1     A68     T2-5     B1     A68
  T2-4     B1     A69     T2-5     B1     A69
  T2-4     B1     A70     T2-5     B1     A70
  T2-4     B1     A76     T2-5     B1     A76
  T2-4     B1     A77     T2-5     B1     A77
  T2-4     B1     A78     T2-5     B1     A78
  T2-4     B1     A106     T2-5     B1     A106
  T2-4     B1     A110     T2-5     B1     A110
  T5-1     B1     A2     T7-1     B1     A2
  T5-1     B1     A5     T7-1     B1     A5
  T5-1     B1     A35     T7-1     B1     A35
  T5-1     B1     A37     T7-1     B1     A37
  T5-1     B1     A45     T7-1     B1     A45
  T5-1     B1     A46     T7-1     B1     A46
  T5-1     B1     A49     T7-1     B1     A49
  T5-1     B1     A54     T7-1     B1     A54
  T5-1     B1     A66     T7-1     B1     A66
  T5-1     B1     A67     T7-1     B1     A67
  T5-1     B1     A68     T7-1     B1     A68
  T5-1     B1     A69     T7-1     B1     A69
  T5-1     B1     A70     T7-1     B1     A70
  T5-1     B1     A76     T7-1     B1     A76
  T5-1     B1     A77     T7-1     B1     A77
  T5-1     B1     A78     T7-1     B1     A78
  T5-1     B1     A106     T7-1     B1     A106
  T5-1     B1     A110     T7-1     B1     A110
                                   表6
  T1-1     B4     A2     T2-1     B4     A2
  T1-1     B4     A5     T2-1     B4     A5
  T1-1     B4     A35     T2-1     B4     A35
  T1-1     B4     A37     T2-1     B4     A37
  T1-1     B4     A45     T2-1     B4     A45
  T1-1     B4     A46     T2-1     B4     A46
  T1-1     B4     A49     T2-1     B4     A49
  T1-1     B4     A54     T2-1     B4     A54
  T1-1     B4     A66     T2-1     B4     A66
  T1-1     B4     A67     T2-1     B4     A67
  T1-1     B4     A68     T2-1     B4     A68
  T1-1     B4     A69     T2-1     B4     A69
  T1-1     B4     A70     T2-1     B4     A70
  T1-1     B4     A76     T2-1     B4     A76
  T1-1     B4     A77     T2-1     B4     A77
  T1-1     B4     A78     T2-1     B4     A78
  T1-1     B4     A106     T2-1     B4     A106
  T1-1     B4     A110     T2-1     B4     A110
  T2-2     B4     A2     T2-3     B4     A2
  T2-2     B4     A5     T2-3     B4     A5
  T2-2     B4     A35     T2-3     B4     A35
  T2-2     B4     A37     T2-3     B4     A37
  T2-2     B4     A45     T2-3     B4     A45
  T2-2     B4     A46     T2-3     B4     A46
  T2-2     B4     A49     T2-3     B4     A49
  T2-2     B4     A54     T2-3     B4     A54
  T2-2     B4     A66     T2-3     B4     A66
  T2-2     B4     A67     T2-3     B4     A67
  T2-2     B4     A68     T2-3     B4     A68
  T2-2     B4     A69     T2-3     B4     A69
  T2-2     B4     A70     T2-3     B4     A70
  T2-2     B4     A76     T2-3     B4     A76
  T2-2     B4     A77     T2-3     B4     A77
  T2-2     B4     A78     T2-3     B4     A78
  T2-2     B4     A106     T2-3     B4     A106
  T2-2     B4     A110     T2-3     B4     A110
  T2-4     B4     A2     T2-5     B4     A2
  T2-4     B4     A5     T2-5     B4     A5
  T2-4     B4     A35     T2-5     B4     A35
  T2-4     B4     A37     T2-5     B4     A37
  T2-4     B4     A45     T2-5     B4     A45
  T2-4     B4     A46     T2-5     B4     A46
  T2-4     B4     A49     T2-5     B4     A49
  T2-4     B4     A54     T2-5     B4     A54
                                    表7
  T2-4     B4     A66     T2-5     B4     A66
  T2-4     B4     A67     T2-5     B4     A67
  T2-4     B4     A68     T2-5     B4     A68
  T2-4     B4     A69     T2-5     B4     A69
  T2-4     B4     A70     T2-5     B4     A70
  T2-4     B4     A76     T2-5     B4     A76
  T2-4     B4     A77     T2-5     B4     A77
  T2-4     B4     A78     T2-5     B4     A78
  T2-4     B4     A106     T2-5     B4     A106
  T2-4     B4     A110     T2-5     B4     A110
  T5-1     B4     A2     T7-1     B4     A2
  T5-1     B4     A5     T7-1     B4     A5
  T5-1     B4     A35     T7-1     B4     A35
  T5-1     B4     A37     T7-1     B4     A37
  T5-1     B4     A45     T7-1     B4     A45
  T5-1     B4     A46     T7-1     B4     A46
  T5-1     B4     A49     T7-1     B4     A49
  T5-1     B4     A54     T7-1     B4     A54
  T5-1     B4     A66     T7-1     B4     A66
  T5-1     B4     A67     T7-1     B4     A67
  T5-1     B4     A68     T7-1     B4     A68
  T5-1     B4     A69     T7-1     B4     A69
  T5-1     B4     A70     T7-1     B4     A70
  T5-1     B4     A76     T7-1     B4     A76
  T5-1     B4     A77     T7-1     B4     A77
  T5-1     B4     A78     T7-1     B4     A78
  T5-1     B4     A106     T7-1     B4     A106
  T5-1     B4     A110     T7-1     B4     A110
  T1-1     B7     A2     T2-1     B7     A2
  T1-1     B7     A5     T2-1     B7     A5
  T1-1     B7     A35     T2-1     B7     A35
  T1-1     B7     A37     T2-1     B7     A37
  T1-1     B7     A45     T2-1     B7     A45
  T1-1     B7     A46     T2-1     B7     A46
  T1-1     B7     A49     T2-1     B7     A49
  T1-1     B7     A54     T2-1     B7     A54
  T1-1     B7     A66     T2-1     B7     A66
  T1-1     B7     A67     T2-1     B7     A67
  T1-1     B7     A68     T2-1     B7     A68
  T1-1     B7     A69     T2-1     B7     A69
  T1-1     B7     A70     T2-1     B7     A70
  T1-1     B7     A76     T2-1     B7     A76
  T1-1     B7     A77     T2-1     B7     A77
  T1-1     B7     A78     T2-1     B7     A78
                             表8
  T1-1     B7     A106     T2-1     B7     A106
  T1-1     B7     A110     T2-1     B7     A110
  T2-2     B7     A2     T2-3     B7     A2
  T2-2     B7     A5     T2-3     B7     A5
  T2-2     B7     A35     T2-3     B7     A35
  T2-2     B7     A37     T2-3     B7     A37
  T2-2     B7     A45     T2-3     B7     A45
  T2-2     B7     A46     T2-3     B7     A46
  T2-2     B7     A49     T2-3     B7     A49
  T2-2     B7     A54     T2-3     B7     A54
  T2-2     B7     A66     T2-3     B7     A66
  T2-2     B7     A67     T2-3     B7     A67
  T2-2     B7     A68     T2-3     B7     A68
  T2-2     B7     A69     T2-3     B7     A69
  T2-2     B7     A70     T2-3     B7     A70
  T2-2     B7     A76     T2-3     B7     A76
  T2-2     B7     A77     T2-3     B7     A77
  T2-2     B7     A78     T2-3     B7     A78
  T2-2     B7     A106     T2-3     B7     A106
  T2-2     B7     A110     T2-3     B7     A110
  T2-4     B7     A2     T2-5     B7     A2
  T2-4     B7     A5     T2-5     B7     A5
  T2-4     B7     A35     T2-5     B7     A35
  T2-4     B7     A37     T2-5     B7     A37
  T2-4     B7     A45     T2-5     B7     A45
  T2-4     B7     A46     T2-5     B7     A46
  T2-4     B7     A49     T2-5     B7     A49
  T2-4     B7-     A54     T2-5     B7     A54
  T2-4     B7     A66     T2-5     B7     A66
  T2-4     B7     A67     T2-5     B7     A67
  T2-4     B7     A68     T2-5     B7     A68
  T2-4     B7     A69     T2-5     B7     A69
  T2-4     B7     A70     T2-5     B7     A70
  T2-4     B7     A76     T2-5     B7     A76
  T2-4     B7     A77     T2-5     B7     A77
  T2-4     B7     A78     T2-5     B7     A78
  T2-4     B7     A106     T2-5     B7     A106
  T2-4     B7     A110     T2-5     B7     A110
  T5-1     B7     A2     T7-1     B7     A2
  T5-1     B7     A5     T7-1     B7     A5
  T5-1     B7     A35     T7-1     B7     A35
  T5-1     B7     A37     T7-1     B7     A37
  T5-1     B7     A45     T7-1     B7     A45
                                   表9
  T5-1     B7     A46     T7-1     B7     A46
  T5-1     B7     A49     T7-1     B7     A49
  T5-1     B7     A54     T7-1     B7     A54
  T5-1     B7     A66     T7-1     B7     A66
  T5-1     B7     A67     T7-1     B7     A67
  T5-1     B7     A68     T7-1     B7     A68
  T5-1     B7     A69     T7-1     B7     A69
  T5-1     B7     A70     T7-1     B7     A70
  T5-1     B7     A76     T7-1     B7     A76
  T5-1     B7     A77     T7-1     B7     A77
  T5-1     B7     A78     T7-1     B7     A78
  T5-1     B7     A106     T7-1     B7     A106
  T5-1     B7     A110     T7-1     B7     A110
  T1-1     B8     A2     T2-1     B8     A2
  T1-1     B8     A5     T2-1     B8     A5
  T1-1     B8     A35     T2-1     B8     A35
  T1-1     B8     A37     T2-1     B8     A37
  T1-1     B8     A45     T2-1     B8     A45
  T1-1     B8     A46     T2-1     B8     A46
  T1-1     B8     A49     T2-1     B8     A49
  T1-1     B8     A54     T2-1     B8     A54
  T1-1     B8     A66     T2-1     B8     A66
  T1-1     B8     A67     T2-1     B8     A67
  T1-1     B8     A68     T2-1     B8     A68
  T1-1     B8     A69     T2-1     B8     A69
  T1-1     B8     A70     T2-1     B8     A70
  T1-1     B8     A76     T2-1     B8     A76
  T1-1     B8     A77     T2-1     B8     A77
  T1-1     B8     A78     T2-1     B8     A78
  T1-1     B8     A106     T2-1     B8     A106
  T1-1     B8     A110     T2-1     B8     A110
  T2-2     B8     A2     T2-3     B8     A2
  T2-2     B8     A5     T2-3     B8     A5
  T2-2     B8     A35     T2-3     B8     A35
  T2-2     B8     A37     T2-3     B8     A37
  T2-2     B8     A45     T2-3     B8     A45
  T2-2     B8     A46     T2-3     B8     A46
  T2-2     B8     A49     T2-3     B8     A49
  T2-2     B8     A54     T2-3     B8     A54
  T2-2     B8     A66     T2-3     B8     A66
  T2-2     B8     A67     T2-3     B8     A67
  T2-2     B8     A68     T2-3     B8     A68
  T2-2     B8     A69     T2-3     B8     A69
                                 表10
  T2-2     B8     A70     T2-3     B8     A70
  T2-2     B8     A76     T2-3     B8     A76
  T2-2     B8     A77     T2-3     B8     A77
  T2-2     B8     A78     T2-3     B8     A78
  T2-2     B8     A106     T2-3     B8     A106
  T2-2     B8     A110     T2-3     B8     A110
  T2-4     B8     A2     T2-5     B8     A2
  T2-4     B8     A5     T2-5     B8     A5
  T2-4     B8     A35     T2-5     B8     A35
  T2-4     B8     A37     T2-5     B8     A37
  T2-4     B8     A45     T2-5     B8     A45
  T2-4     B8     A46     T2-5     B8     A46
  T2-4     B8     A49     T2-5     B8     A49
  T2-4     B8     A54     T2-5     B8     A54
  T2-4     B8     A66     T2-5     B8     A66
  T2-4     B8     A67     T2-5     B8     A67
  T2-4     B8     A68     T2-5     B8     A68
  T2-4     B8     A69     T2-5     B8     A69
  T2-4     B8     A70     T2-5     B8     A70
  T2-4     B8     A76     T2-5     B8     A76
  T2-4     B8     A77     T2-5     B8     A77
  T2-4     B8     A78     T2-5     B8     A78
  T2-4     B8     A106     T2-5     B8     A106
  T2-4     B8     A110     T2-5     B8     A110
  T5-1     B8     A2     T7-1     B8     A2
  T5-1     B8     A5     T7-1     B8     A5
  T5-1     B8     A35     T7-1     B8     A35
  T5-1     B8     A37     T7-1     B8     A37
  T5-1     B8     A45     T7-1     B8     A45
  T5-1     B8     A46     T7-1     B8     A46
  T5-1     B8     A49     T7-1     B8     A49
  T5-1     B8     A54     T7-1     B8     A54
  T5-1     B8     A66     T7-1     B8     A66
  T5-1     B8     A67     T7-1     B8     A67
  T5-1     B8     A68     T7-1     B8     A68
  T5-1     B8     A69     T7-1     B8     A69
  T5-1     B8     A70     T7-1     B8     A70
  T5-1     B8     A76     T7-1     B8     A76
  T5-1     B8     A77     T7-1     B8     A77
  T5-1     B8     A78     T7-1     B8     A78
  T5-1     B8     A106     T7-1     B8     A106
  T5-1     B8     A110     T7-1     B8     A110
  T1-1     B9     A2     T2-1     B9     A2
                                        表11
  T1-1     B9     A5     T2-1     B9     A5
  T1-1     B9     A35     T2-1     B9     A35
  T1-1     B9     A37     T2-1     B9     A37
  T1-1     B9     A45     T2-1     B9     A45
  T1-1     B9     A46     T2-1     B9     A46
  T1-1     B9     A49     T2-1     B9     A49
  T1-1     B9     A54     T2-1     B9     A54
  T1-1     B9     A66     T2-1     B9     A66
  T1-1     B9     A67     T2-1     B9     A67
  T1-1     B9     A68     T2-1     B9     A68
  T1-1     B9     A69     T2-1     B9     A69
  T1-1     B9     A70     T2-1     B9     A70
  T1-1     B9     A76     T2-1     B9     A76
  T1-1     B9     A77     T2-1     B9     A77
  T1-1     B9     A78     T2-1     B9     A78
  T1-1     B9     A106     T2-1     B9     A106
  T1-1     B9     A110     T2-1     B9     A110
  T2-2     B9     A2     T2-3     B9     A2
  T2-2     B9     A5     T2-3     B9     A5
  T2-2     B9     A35     T2-3     B9     A35
  T2-2     B9     A37     T2-3     B9     A37
  T2-2     B9     A45     T2-3     B9     A45
  T2-2     B9     A46     T2-3     B9     A46
  T2-2     B9     A49     T2-3     B9     A49
  T2-2     B9     A54     T2-3     B9     A54
  T2-2     B9     A66     T2-3     B9     A66
  T2-2     B9     A67     T2-3     B9     A67
  T2-2     B9     A68     T2-3     B9     A68
  T2-2     B9     A69     T2-3     B9     A69
  T2-2     B9     A70     T2-3     B9     A70
  T2-2     B9     A76     T2-3     B9     A76
  T2-2     B9     A77     T2-3     B9     A77
  T2-2     B9     A78     T2-3     B9     A78
  T2-2     B9     A106     T2-3     B9     A106
  T2-2     B9     A110     T2-3     B9     A110
  T2-4     B9     A2     T2-5     B9     A2
  T2-4     B9     A5     T2-5     B9     A5
  T2-4     B9     A35     T2-5     B9     A35
  T2-4     B9     A37     T2-5     B9     A37
  T2-4     B9     A45     T2-5     B9     A45
  T2-4     B9     A46     T2-5     B9     A46
  T2-4     B9     A49     T2-5     B9     A49
  T2-4     B9     A54     T2-5     B9     A54
                                     表12
  T2-4     B9     A66     T2-5     B9     A66
  T2-4     B9     A67     T2-5     B9     A67
  T2-4     B9     A68     T2-5     B9     A68
  T2-4     B9     A69     T2-5     B9     A69
  T2-4     B9     A70     T2-5     B9     A70
  T2-4     B9     A76     T2-5     B9     A76
  T2-4     B9     A77     T2-5     B9     A77
  T2-4     B9     A78     T2-5     B9     A78
  T2-4     B9     A106     T2-5     B9     A106
  T2-4     B9     A110     T2-5     B9     A110
  T5-1     B9     A2     T7-1     B9     A2
  T5-1     B9     A5     T7-1     B9     A5
  T5-1     B9     A35     T7-1     B9     A35
  T5-1     B9     A37     T7-1     B9     A37
  T5-1     B9     A45     T7-1     B9     A45
  T5-1     B9     A46     T7-1     B9     A46
  T5-1     B9     A49     T7-1     B9     A49
  T5-1     B9     A54     T7-1     B9     A54
  T5-1     B9     A66     T7-1     B9     A66
  T5-1     B9     A67     T7-1     B9     A67
  T5-1     B9     A68     T7-1     B9     A68
  T5-1     B9     A69     T7-1     B9     A69
  T5-1     B9     A70     T7-1     B9     A70
  T5-1     B9     A76     T7-1     B9     A76
  T5-1     B9     A77     T7-1     B9     A77
  T5-1     B9     A78     T7-1     B9     A78
  T5-1     B9     A106     T7-1     B9     A106
  T5-1     B9     A110     T7-1     B9     A110
  T1-1     B10     A2     T2-1     B10     A2
  T1-1     B10     A5     T2-1     B10     A5
  T1-1     B10     A35     T2-1     B10     A35
  T1-1     B10     A37     T2-1     B10     A37
  T1-1     B10     A45     T2-1     B10     A45
  T1-1     B10     A46     T2-1     B10     A46
  T1-1     B10     A49     T2-1     B10     A49
  T1-1     B10     A54     T2-1     B10     A54
  T1-1     B10     A66     T2-1     B10     A66
  T1-1     B10     A67     T2-1     B10     A67
  T1-1     B10     A68     T2-1     B10     A68
  T1-1     B10     A69     T2-1     B10     A69
  T1-1     B10     A70     T2-1     B10     A70
  T1-1     B10     A76     T2-1     B10     A76
  T1-1     B10     A77     T2-1     B10     A77
  T1-1     B10     A78     T2-1     B10     A78
                                  表13
  T1-1     B10     A106     T2-1     B10     A106
  T1-1     B10     A110     T2-1     B10     A110
  T2-2     B10     A2     T2-3     B10     A2
  T2-2     B10     A5     T2-3     B10     A5
  T2-2     B10     A35     T2-3     B10     A35
  T2-2     B10     A37     T2-3     B10     A37
  T2-2     B10     A45     T2-3     B10     A45
  T2-2     B10     A46     T2-3     B10     A46
  T2-2     B10     A49     T2-3     B10     A49
  T2-2     B10     A54     T2-3     B10     A54
  T2-2     B10     A66     T2-3     B10     A66
  T2-2     B10     A67     T2-3     B10     A67
  T2-2     B10     A68     T2-3     B10     A68
  T2-2     B10     A69     T2-3     B10     A69
  T2-2     B10     A70     T2-3     B10     A70
  T2-2     B10     A76     T2-3     B10     A76
  T2-2     B10     A77     T2-3     B10     A77
  T2-2     B10     A78     T2-3     B10     A73
  T2-2     B10     A106     T2-3     B10     A106
  T2-2     B10     A110     T2-3     B10     A110
  T2-4     B10     A2     T2-5     B10     A2
  T2-4     B10     A5     T2-5     B10     A5
  T2-4     B10     A35     T2-5     B10     A35
  T2-4     B10     A37     T2-5     B10     A37
  T2-4     B10     A45     T2-5     B10     A45
  T2-4     B10     A46     T2-5     B10     A46
  T2-4     B10     A49     T2-5     B10     A49
  T2-4     B10     A54     T2-5     B10     A54
  T2-4     B10     A66     T2-5     B10     A66
  T2-4     B10     A67     T2-5     B10     A67
  T2-4     B10     A68     T2-5     B10     A68
  T2-4     B10     A69     T2-5     B10     A69
  T2-4     B10     A70     T2-5     B10     A70
  T2-4     B10     A76     T2-5     B10     A76
  T2-4     B10     A77     T2-5     B10     A77
  T2-4     B10     A78     T2-5     B10     A78
  T2-4     B10     A106     T2-5     B10     A106
  T2-4     B10     A110     T2-5     B10     A110
  T5-1     B10     A2     T7-1     B10     A2
  T5-1     B10     A5     T7-1     B10     A5
  T5-1     B10     A35     T7-1     B10     A35
  T5-1     B10     A37     T7-1     B10     A37
  T5-1     B10     A45     T7-1     B10     A45
                                  表14
  T5-1     B10     A46     T7-1     B10     A46
  T5-1     B10     A49     T7-1     B10     A49
  T5-1     B10     A54     T7-1     B10     A54
  T5-1     B10     A86     T7-1     B10     A66
  T5-1     B10     A67     T7-1     B10     A67
  T5-1     B10     A68     T7-1     B10     A68
  T5-1     B10     A69     T7-1     B10     A69
  T5-1     B10     A70     T7-1     B10     A70
  T5-1     B10     A76     T7-1     B10     A76
  T5-1     B10     A77     T7-1     B10     A77
  T5-1     B10     A78     T7-1     B10     A78
  T5-1     B10     A106     T7-1     B10     A106
  T5-1     B10     A110     T7-1     B10     A110
  T1-1     B12     A2     T2-1     B12     A2
  T1-1     B12     A5     T2-1     B12     A5
  T1-1     B12     A35     T2-1     B12     A35
  T1-1     B12     A37     T2-1     B12     A37
  T1-1     B12     A45     T2-1     B12     A45
  T1-1     B12     A46     T2-1     B12     A46
  T1-1     B12     A49     T2-1     B12     A49
  T1-1     B12     A54     T2-1     B12     A54
  T1-1     B12     A66     T2-1     B12     A66
  T1-1     B12     A67     T2-1     B12     A67
  T1-1     B12     A68     T2-1     B12     A68
  T1-1     B12     A69     T2-1     B12     A69
  T1-1     B12     A70     T2-1     B12     A70
  T1-1     B12     A76     T2-1     B12     A76
  T1-1     B12     A77     T2-1     B12     A77
  T1-1     B12     A78     T2-1     B12     A78
  T1-1     B12     A106     T2-1     B12     A106
  T1-1     B12     A110     T2-1     B12     A110
  T2-2     B12     A2     T2-3     B12     A2
  T2-2     B12     A5     T2-3     B12     A5
  T2-2     B12     A35     T2-3     B12     A35
  T2-2     B12     A37     T2-3     B12     A37
  T2-2     B12     A45     T2-3     B12     A45
  T2-2     B12     A46     T2-3     B12     A46
  T2-2     B12     A49     T2-3     B12     A49
  T2-2     B12     A54     T2-3     B12     A54
  T2-2     B12     A66     T2-3     B12     A66
  T2-2     B12     A67     T2-3     B12     A67
  T2-2     B12     A68     T2-3     B12     A68
  T2-2     B12     A69     T2-3     B12     A69
                                    表15
  T2-2     B12     A70     T2-3     B12     A70
  T2-2     B12     A76     T2-3     B12     A76
  T2-2     B12     A77     T2-3     B12     A77
  T2-2     B12     A78     T2-3     B12     A78
  T2-2     B12     A106     T2-3     B12     A106
  T2-2     B12     A110     T2-3     B12     A110
  T2-4     B12     A2     T2-5     B12     A2
  T2-4     B12     A5     T2-5     B12     A5
  T2-4     B12     A35     T2-5     B12     A35
  T2-4     B12     A37     T2-5     B12     A37
  T2-4     B12     A45     T2-5     B12     A45
  T2-4     B12     A46     T2-5     B12     A46
  T2-4     B12     A49     T2-5     B12     A49
  T2-4     B12     A54     T2-5     B12     A54
  T2-4     B12     A66     T2-5     B12     A66
  T2-4     B12     A67     T2-5     B12     A67
  T2-4     B12     A68     T2-5     B12     A68
  T2-4     B12     A69     T2-5     B12     A69
  T2-4     B12     A70     T2-5     B12     A70
  T2-4     B12     A76     T2-5     B12     A76
  T2-4     B12     A77     T2-5     B12     A77
  T2-4     B12     A78     T2-5     B12     A78
  T2-4     B12     A106     T2-5     B12     A106
  T2-4     B12     A110     T2-5     B12     A110
  T5-1     B12     A2     T7-1     B12     A2
  T5-1     B12     A5     T7-1     B12     A5
  T5-1     B12     A35     T7-1     B12     A35
  T5-1     B12     A37     T7-1     B12     A37
  T5-1     B12     A45     T7-1     B12     A45
  T5-1     B12     A46     T7-1     B12     A46
  T5-1     B12     A49     T7-1     B12     A49
  T5-1     B12     A54     T7-1     B12     A54
  T5-1     B12     A66     T7-1     B12     A66
  T5-1     B12     A67     T7-1     B12     A67
  T5-1     B12     A68     T7-1     B12     A68
  T5-1     B12     A69     T7-1     B12     A69
  T5-1     B12     A70     T7-1     B12     A70
  T5-1     B12     A76     T7-1     B12     A76
  T5-1     B12     A77     T7-1     B12     A77
  T5-1     B12     A78     T7-1     B12     A78
  T5-1     B12     A106     T7-1     B12     A106
  T5-1     B12     A110     T7-1     B12     A110
  T1-1     B14     A2     T2-1     B14     A2
                                     表16
  T1-1     B14     A5     T2-1     B14     A5
  T1-1     B14     A35     T2-1     B14     A35
  T1-1     B14     A37     T2-1     B14     A37
  T1-1     B14     A45     T2-1     B14     A45
  T1-1     B14     A46     T2-1     B14     A46
  T1-1     B14     A49     T2-1     B14     A49
  T1-1     B14     A54     T2-1     B14     A54
  T1-1     B14     A66     T2-1     B14     A66
  T1-1     B14     A67     T2-1     B14     A67
  T1-1     B14     A68     T2-1     B14     A68
  T1-1     B14     A69     T2-1     B14     A69
  T1-1     B14     A70     T2-1     B14     A70
  T1-1     B14     A76     T2-1     B14     A76
  T1-1     B14     A77     T2-1     B14     A77
  T1-1     B14     A78     T2-1     B14     A78
  T1-1     B14     A106     T2-1     B14     A106
  T1-1     B14     A110     T2-1     B14     A110
  T2-2     B14     A2     T2-3     B14     A2
  T2-2     B14     A5     T2-3     B14     A5
  T2-2     B14     A35     T2-3     B14     A35
  T2-2     B14     A37     T2-3     B14     A37
  T2-2     B14     A45     T2-3     B14     A45
  T2-2     B14     A46     T2-3     B14     A46
  T2-2     B14     A49     T2-3     B14     A49
  T2-2     B14     A54     T2-3     B14     A54
  T2-2     B14     A66     T2-3     B14     A66
  T2-2     B14     A67     T2-3     B14     A67
  T2-2     B14     A68     T2-3     B14     A68
  T2-2     B14     A69     T2-3     B14     A69
  T2-2     B14     A70     T2-3     B14     A70
  T2-2     B14     A76     T2-3     B14     A76
  T2-2     B14     A77     T2-3     B14     A77
  T2-2     B14     A78     T2-3     B14     A78
  T2-2     B14     A106     T2-3     B14     A106
  T2-2     B14     A110     T2-3     B14     A110
  T2-4     B14     A2     T2-5     B14     A2
  T2-4     B14     A5     T2-5     B14     A5
  T2-4     B14     A35     T2-5     B14     A35
  T2-4     B14     A37     T2-5     B14     A37
  T2-4     B14     A45     T2-5     B14     A45
  T2-4     B14     A46     T2-5     B14     A46
  T2-4     B14     A49     T2-5     B14     A49
  T2-4     B14     A54     T2-5     B14     A54
                                   表17
  T2-4     B14     A66     T2-5     B14     A66
  T2-4     B14     A67     T2-5     B14     A67
  T2-4     B14     A68     T2-5     B14     A68
  T2-4     B14     A69     T2-5     B14     A69
  T2-4     B14     A70     T2-5     B14     A70
  T2-4     B14     A76     T2-5     B14     A76
  T2-4     B14     A77     T2-5     B14     A77
  T2-4     B14     A78     T2-5     B14     A78
  T2-4     B14     A106     T2-5     B14     A106
  T2-4     B14     A110     T2-5     B14     A110
  T5-1     B14     A2     T7-1     B14     A2
  T5-1     B14     A5     T7-1     B14     A5
  T5-1     B14     A35     T7-1     B14     A35
  T5-1     B14     A37     T7-1     B14     A37
  T5-1     B14     A45     T7-1     B14     A45
  T5-1     B14     A46     T7-1     B14     A46
  T5-1     B14     A49     T7-1     B14     A49
  T5-1     B14     A54     T7-1     B14     A54
  T5-1     B14     A66     T7-1     B14     A66
  T5-1     B14     A67     T7-1     B14     A67
  T5-1     B14     A68     T7-1     B14     A68
  T5-1     B14     A69     T7-1     B14     A69
  T5-1     B14     A70     T7-1     B14     A70
  T5-1     B14     A76     T7-1     B14     A76
  T5-1     B14     A77     T7-1     B14     A77
  T5-1     B14     A78     T7-1     B14     A78
  T5-1     B14     A106     T7-1     B14     A106
  T5-1     B14     A110     T7-1     B14     A110
  T1-1     B16     A2     T2-1     B16     A2
  T1-1     B16     A5     T2-1     B16     A5
  T1-1     B16     A35     T2-1     B16     A35
  T1-1     B16     A37     T2-1     B16     A37
  T1-1     B16     A45     T2-1     B16     A45
  T1-1     B16     A46     T2-1     B16     A46
  T1-1     B16     A49     T2-1     B16     A49
  T1-1     B16     A54     T2-1     B16     A54
  T1-1     B16     A66     T2-1     B16     A66
  T1-1     B16     A67     T2-1     B16     A67
  T1-1     B16     A68     T2-1     B16     A68
  T1-1     B16     A69     T2-1     B16     A69
  T1-1     B16     A70     T2-1     B16     A70
  T1-1     B16     A76     T2-1     B16     A76
  T1-1     B16     A77     T2-1     B16     A77
                                        表18
  T1-1     B16     A78     T2-1     B16     A78
  T1-1     B16     A106     T2-1     B16     A106
  T1-1     B16     A110     T2-1     B16     A110
  T2-2     B16     A2     T2-3     B16     A2
  T2-2     B16     A5     T2-3     B16     A5
  T2-2     B16     A35     T2-3     B16     A35
  T2-2     B16     A37     T2-3     B16     A37
  T2-2     B16     A45     T2-3     B16     A45
  T2-2     B16     A46     T2-3     B16     A46
  T2-2     B16     A49     T2-3     B16     A49
  T2-2     B16     A54     T2-3     B16     A54
  T2-2     B16     A66     T2-3     B16     A66
  T2-2     B16     A67     T2-3     B16     A67
  T2-2     B16     A68     T2-3     B16     A68
  T2-2     B16     A69     T2-3     B16     A69
  T2-2     B16     A70     T2-3     B16     A70
  T2-2     B16     A76     T2-3     B16     A76
  T2-2     B16     A77     T2-3     B16     A77
  T2-2     B16     A78     T2-3     B16     A78
  T2-2     B16     A106     T2-3     B16     A106
  T2-2     B16     A110     T2-3     B16     A110
  T2-4     B16     A2     T2-5     B16     A2
  T2-4     B16     A5     T2-5     B16     A5
  T2-4     B16     A35     T2-5     B16     A35
  T2-4     B16     A37     T2-5     B16     A37
  T2-4     B16     A45     T2-5     B16     A45
  T2-4     B16     A46     T2-5     B16     A46
  T2-4     B16     A49     T2-5     B16     A49
  T2-4     B16     A54     T2-5     B16     A54
  T2-4     B16     A66     T2-5     B16     A66
  T2-4     B16     A67     T2-5     B16     A67
  T2-4     B16     A68     T2-5     B16     A68
  T2-4     B16     A69     T2-5     B16     A69
  T2-4     B16     A70     T2-5     B16     A70
  T2-4     B16     A76     T2-5     B16     A76
  T2-4     B16     A77     T2-5     B16     A77
  T2-4     B16     A78     T2-5     B16     A78
  T2-4     B16     A106     T2-5     B16     A106
  T2-4     B16     A110     T2-5     B16     A110
  T5-1     B16     A2     T7-1     B16     A2
  T5-1     B16     A5     T7-1     B16     A5
  T5-1     B16     A35     T7-1     B16     A35
  T5-1     B16     A37     T7-1     B16     A37
                                       表19
  T5-1     B16     A45     T7-1     B16     A45
  T5-1     B16     A46     T7-1     B16     A46
  T5-1     B16     A49     T7-1     B16     A49
  T5-1     B16     A54     T7-1     B16     A54
  T5-1     B16     A66     T7-1     B16     A66
  T5-1     B16     A67     T7-1     B16     A67
  T5-1     B16     A68     T7-1     B16     A68
  T5-1     B16     A69     T7-1     B16     A69
  T5-1     B16     A70     T7-1     B16     A70
  T5-1     B16     A76     T7-1     B16     A76
  T5-1     B16     A77     T7-1     B16     A77
  T5-1     B16     A78     T7-1     B16     A78
  T5-1     B16     A106     T7-1     B16     A106
  T5-1     B16     A110     T7-1     B16     A110
  T1-1     B17     A2     T2-1     B17     A2
  T1-1     B17     A5     T2-1     B17     A5
  T1-1     B17     A35     T2-1     B17     A35
  T1-1     B17     A37     T2-1     B17     A37
  T1-1     B17     A45     T2-1     B17     A45
  T1-1     B17     A46     T2-1     B17     A46
  T1-1     B17     A49     T2-1     B17     A49
  T1-1     B17     A54     T2-1     B17     A54
  T1-1     B17     A66     T2-1     B17     A66
  T1-1     B17     A67     T2-1     B17     A67
  T1-1     B17     A68     T2-1     B17     A68
  T1-1     B17     A69     T2-1     B17     A69
  T1-1     B17     A70     T2-1     B17     A70
  T1-1     B17     A76     T2-1     B17     A76
  T1-1     B17     A77     T2-1     B17     A77
  T1-1     B17     A78     T2-1     B17     A78
  T1-1     B17     A106     T2-1     B17     A106
  T1-1     B17     A110     T2-1     B17     A110
  T2-2     B17     A2     T2-3     B17     A2
  T2-2     B17     A5     T2-3     B17     A5
  T2-2     B17     A35     T2-3     B17     A35
  T2-2     B17     A37     T2-3     B17     A37
  T2-2     B17     A45     T2-3     B17     A45
  T2-2     B17     A46     T2-3     B17     A46
  T2-2     B17     A49     T2-3     B17     A49
  T2-2     B17     A54     T2-3     B17     A54
  T2-2     B17     A66     T2-3     B17     A66
  T2-2     B17     A67     T2-3     B17     A67
  T2-2     B17     A68     T2-3     B17     A68
                                        表20
  T2-2     B17     A69     T2-3     B17     A69
  T2-2     B17     A70     T2-3     B17     A70
  T2-2     B17     A76     T2-3     B17     A76
  T2-2     B17     A77     T2-3     B17     A77
  T2-2     B17     A78     T2-3     B17     A78
  T2-2     B17     A106     T2-3     B17     A106
  T2-2     B17     A110     T2-3     B17     A110
  T2-4     B17     A2     T2-5     B17     A2
  T2-4     B17     A5     T2-5     B17     A5
  T2-4     B17     A35     T2-5     B17     A35
  T2-4     B17     A37     T2-5     B17     A37
  T2-4     B17     A45     T2-5     B17     A45
  T2-4     B17     A46     T2-5     B17     A46
  T2-4     B17     A49     T2-5     B17     A49
  T2-4     B17     A54     T2-5     B17     A54
  T2-4     B17     A66     T2-5     B17     A66
  T2-4     B17     A67     T2-5     B17     A67
  T2-4     B17     A68     T2-5     B17     A68
  T2-4     B17     A69     T2-5     B17     A69
  T2-4     B17     A70     T2-5     B17     A70
  T2-4     B17     A76     T2-5     B17     A76
  T2-4     B17     A77     T2-5     B17     A77
  T2-4     B17     A78     T2-5     B17     A78
  T2-4     B17     A106     T2-5     B17     A106
  T2-4     B17     A110     T2-5     B17     A110
  T5-1     B17     A2     T7-1     B17     A2
  T5-1     B17     A5     T7-1     B17     A5
  T5-1     B17     A35     T7-1     B17     A35
  T5-1     B17     A37     T7-1     B17     A37
  T5-1     B17     A45     T7-1     B17     A45
  T5-1     B17     A46     T7-1     B17     A46
  T5-1     B17     A49     T7-1     B17     A49
  T5-1     B17     A54     T7-1     B17     A54
  T5-1     B17     A66     T7-1     B17     A66
  T5-1     B17     A67     T7-1     B17     A67
  T5-1     B17     A68     T7-1     B17     A68
  T5-1     B17     A69     T7-1     B17     A69
  T5-1     B17     A70     T7-1     B17     A70
  T5-1     B17     A76     T7-1     B17     A76
  T5-1     B17     A77     T7-1     B17     A77
  T5-1     B17     A78     T7-1     B17     A78
  T5-1     B17     A106     T7-1     B17     A106
  T5-1     B17     A110     T7-1     B17     A110
                                        表21
  T1-1     B24     A2     T2-1     B24     A2
  T1-1     B24     A5     T2-1     B24     A5
  T1-1     B24     A35     T2-1     B24     A35
  T1-1     B24     A37     T2-1     B24     A37
  T1-1     B24     A45     T2-1     B24     A45
  T1-1     B24     A46     T2-1     B24     A46
  T1-1     B24     A49     T2-1     B24     A49
  T1-1     B24     A54     T2-1     B24     A54
  T1-1     B24     A66     T2-1     B24     A66
  T1-1     B24     A67     T2-1     B24     A67
  T1-1     B24     A68     T2-1     B24     A68
  T1-1     B24     A69     T2-1     B24     A69
  T1-1     B24     A70     T2-1     B24     A70
  T1-1     B24     A76     T2-1     B24     A76
  T1-1     B24     A77     T2-1     B24     A77
  T1-1     B24     A78     T2-1     B24     A78
  T1-1     B24     A106     T2-1     B24     A106
  T1-1     B24     A110     T2-1     B24     A110
  T2-2     B24     A2     T2-3     B24     A2
  T2-2     B24     A5     T2-3     B24     A5
  T2-2     B24     A35     T2-3     B24     A35
  T2-2     B24     A37     T2-3     B24     A37
  T2-2     B24     A45     T2-3     B24     A45
  T2-2     B24     A46     T2-3     B24     A46
  T2-2     B24     A49     T2-3     B24     A49
  T2-2     B24     A54     T2-3     B24     A54
  T2-2     B24     A66     T2-3     B24     A66
  T2-2     B24     A67     T2-3     B24     A67
  T2-2     B24     A68     T2-3     B24     A68
  T2-2     B24     A69     T2-3     B24     A69
  T2-2     B24     A70     T2-3     B24     A70
  T2-2     B24     A76     T2-3     B24     A76
  T2-2     B24     A77     T2-3     B24     A77
  T2-2     B24     A78     T2-3     B24     A78
  T2-2     B24     A106     T2-3     B24     A106
  T2-2     B24     A110     T2-3     B24     A110
  T2-4     B24     A2     T2-5     B24     A2
  T2-4     B24     A5     T2-5     B24     A5
  T2-4     B24     A35     T2-5     B24     A35
  T2-4     B24     A37     T2-5     B24     A37
  T2-4     B24     A45     T2-5     B24     A45
  T2-4     B24     A46     T2-5     B24     A46
  T2-4     B24     A49     T2-5     B24     A49
                                      表22
  T2-4     B24     A54     T2-5     B24     A54
  T2-4     B24     A66     T2-5     B24     A66
  T2-4     B24     A67     T2-5     B24     A67
  T2-4     B24     A68     T2-5     B24     A68
  T2-4     B24     A69     T2-5     B24     A69
  T2-4     B24     A70     T2-5     B24     A70
  T2-4     B24     A76     T2-5     B24     A76
  T2-4     B24     A77     T2-5     B24     A77
  T2-4     B24     A78     T2-5     B24     A78
  T2-4     B24     A106     T2-5     B24     A106
  T2-4     B24     A110     T2-5     B24     A110
  T5-1     B24     A2     T7-1     B24     A2
  T5-1     B24     A5     T7-1     B24     A5
  T5-1     B24     A35     T7-1     B24     A35
  T5-1     B24     A37     T7-1     B24     A37
  T5-1     B24     A45     T7-1     B24     A45
  T5-1     B24     A46     T7-1     B24     A46
  T5-1     B24     A49     T7-1     B24     A49
  T5-1     B24     A54     T7-1     B24     A54
  T5-1     B24     A66     T7-1     B24     A66
  T5-1     B24     A67     T7-1     B24     A67
  T5-1     B24     A68     T7-1     B24     A68
  T5-1     B24     A69     T7-1     B24     A69
  T5-1     B24     A70     T7-1     B24     A70
  T5-1     B24     A76     T7-1     B24     A76
  T5-1     B24     A77     T7-1     B24     A77
  T5-1     B24     A78     T7-1     B24     A78
  T5-1     B24     A106     T7-1     B24     A106
  T5-1     B24     A110     T7-1     B24     A110
  T1-1     B28     A2     T2-1     B28     A2
  T1-1     B28     A5     T2-1     B28     A5
  T1-1     B28     A35     T2-1     B28     A35
  T1-1     B28     A37     T2-1     B28     A37
  T1-1     B28     A45     T2-1     B28     A45
  T1-1     B28     A46     T2-1     B28     A46
  T1-1     B28     A49     T2-1     B28     A49
  T1-1     B28     A54     T2-1     B28     A54
  T1-1     B28     A66     T2-1     B28     A66
  T1-1     B28     A67     T2-1     B28     A67
  T1-1     B28     A68     T2-1     B28     A68
  T1-1     B28     A69     T2-1     B28     A69
  T1-1     B28     A70     T2-1     B28     A70
  T1-1     B28     A76     T2-1     B28     A76
                                     表23
  T1-1     B28     A77     T2-1     B28     A77
  T1-1     B28     A78     T2-1     B28     A78
  T1-1     B28     A106     T2-1     B28     A106
  T1-1     B28     A110     T2-1     B28     A110
  T2-2     B28     A2     T2-3     B28     A2
  T2-2     B28     A5     T2-3     B28     A5
  T2-2     B28     A35     T2-3     B28     A35
  T2-2     B28     A37     T2-3     B28     A37
  T2-2     B28     A45     T2-3     B28     A45
  T2-2     B28     A46     T2-3     B28     A46
  T2-2     B28     A49     T2-3     B28     A49
  T2-2     B28     A54     T2-3     B28     A54
  T2-2     B28     A66     T2-3     B28     A66
  T2-2     B28     A67     T2-3     B28     A67
  T2-2     B28     A68     T2-3     B28     A68
  T2-2     B28     A69     T2-3     B28     A69
  T2-2     B28     A70     T2-3     B28     A70
  T2-2     B28     A76     T2-3     B28     A76
  T2-2     B28     A77     T2-3     B28     A77
  T2-2     B28     A78     T2-3     B28     A78
  T2-2     B28     A106     T2-3     B28     A106
  T2-2     B28     A110     T2-3     B28     A110
  T2-4     B28     A2     T2-5     B28     A2
  T2-4     B28     A5     T2-5     B28     A5
  T2-4     B28     A35     T2-5     B28     A35
  T2-4     B28     A37     T2-5     B28     A37
  T2-4     B28     A45     T2-5     B28     A45
  T2-4     B28     A46     T2-5     B28     A46
  T2-4     B28     A49     T2-5     B28     A49
  T2-4     B28     A54     T2-5     B28     A54
  T2-4     B28     A66     T2-5     B28     A66
  T2-4     B28     A67     T2-5     B28     A67
  T2-4     B28     A68     T2-5     B28     A68
  T2-4     B28     A69     T2-5     B28     A69
  T2-4     B28     A70     T2-5     B28     A70
  T2-4     B28     A76     T2-5     B28     A76
  T2-4     B28     A77     T2-5     B28     A77
  T2-4     B28     A78     T2-5     B28     A78
  T2-4     B28     A106     T2-5     B28     A106
  T2-4     B28     A110     T2-5     B28     A110
  T5-1     B28     A2     T7-1     B28     A2
  T5-1     B28     A5     T7-1     B28     A5
  T5-1     B28     A35     T7-1     B28     A35
                                表24
  T5-1     B28     A37     T7-1     B28     A37
  T5-1     B28     A45     T7-1     B28     A45
  T5-1     B28     A46     T7-1     B28     A46
  T5-1     B28     A49     T7-1     B28     A49
  T5-1     B28     A54     T7-1     B28     A54
  T5-1     B28     A66     T7-1     B28     A66
  T5-1     B28     A67     T7-1     B28     A67
  T5-1     B28     A68     T7-1     B28     A68
  T5-1     B28     A69     T7-1     B28     A69
  T5-1     B28     A70     T7-1     B28     A70
  T5-1     B28     A76     T7-1     B28     A76
  T5-1     B28     A77     T7-1     B28     A77
  T5-1     B28     A78     T7-1     B28     A78
  T5-1     B28     A106     T7-1     B28     A106
  T5-1     B28     A110     T7-1     B28     A110
  T1-1     B29     A2     T2-1     B29     A2
  T1-1     B29     A5     T2-1     B29     A5
  T1-1     B29     A35     T2-1     B29     A35
  T1-1     B29     A37     T2-1     B29     A37
  T1-1     B29     A45     T2-1     B29     A45
  T1-1     B29     A46     T2-1     B29     A46
  T1-1     B29     A49     T2-1     B29     A49
  T1-1     B29     A54     T2-1     B29     A54
  T1-1     B29     A66     T2-1     B29     A66
  T1-1     B29     A67     T2-1     B29     A67
  T1-1     B29     A68     T2-1     B29     A68
  T1-1     B29     A69     T2-1     B29     A69
  T1-1     B29     A70     T2-1     B29     A70
  T1-1     B29     A76     T2-1     B29     A76
  T1-1     B29     A77     T2-1     B29     A77
  T1-1     B29     A78     T2-1     B29     A78
  T1-1     B29     A106     T2-1     B29     A106
  T1-1     B29     A110     T2-1     B29     A110
  T2-2     B29     A2     T2-3     B29     A2
  T2-2     B29     A5     T2-3     B29     A5
  T2-2     B29     A35     T2-3     B29     A35
  T2-2     B29     A37     T2-3     B29     A37
  T2-2     B29     A45     T2-3     B29     A45
  T2-2     B29     A46     T2-3     B29     A46
  T2-2     B29     A49     T2-3     B29     A49
  T2-2     B29     A54     T2-3     B29     A54
  T2-2     B29     A66     T2-3     B29     A66
  T2-2     B29     A67     T2-3     B29     A67
                                       表25
  T2-2     B29     A68     T2-3     B29     A68
  T2-2     B29     A69     T2-3     B29     A69
  T2-2     B29     A70     T2-3     B29     A70
  T2-2     B29     A76     T2-3     B29     A76
  T2-2     B29     A77     T2-3     B29     A77
  T2-2     B29     A78     T2-3     B29     A78
  T2-2     B29     A106     T2-3     B29     A106
  T2-2     B29     A110     T2-3     B29     A110
  T2-4     B29     A2     T2-5     B29     A2
  T2-4     B29     A5     T2-5     B29     A5
  T2-4     B29     A35     T2-5     B29     A35
  T2-4     B29     A37     T2-5     B29     A37
  T2-4     B29     A45     T2-5     B29     A45
  T2-4     B29     A46     T2-5     B29     A46
  T2-4     B29     A49     T2-5     B29     A49
  T2-4     B29     A54     T2-5     B29     A54
  T2-4     B29     A66     T2-5     B29     A66
  T2-4     B29     A67     T2-5     B29     A67
  T2-4     B29     A68     T2-5     B29     A68
  T2-4     B29     A69     T2-5     B29     A69
  T2-4     B29     A70     T2-5     B29     A70
  T2-4     B29     A76     T2-5     B29     A76
  T2-4     B29     A77     T2-5     B29     A77
  T2-4     B29     A78     T2-5     B29     A78
  T2-4     B29     A106     T2-5     B29     A106
  T2-4     B29     A110     T2-5     B29     A110
  T5-1     B29     A2     T7-1     B29     A2
  T5-1     B29     A5     T7-1     B29     A5
  T5-1     B29     A35     T7-1     B29     A35
  T5-1     B29     A37     T7-1     B29     A37
  T5-1     B29     A45     T7-1     B29     A45
  T5-1     B29     A46     T7-1     B29     A46
  T5-1     B29     A49     T7-1     B29     A49
  T5-1     B29     A54     T7-1     B29     A54
  T5-1     B29     A66     T7-1     B29     A66
  T5-1     B29     A67     T7-1     B29     A67
  T5-1     B29     A68     T7-1     B29     A68
  T5-1     B29     A69     T7-1     B29     A69
  T5-1     B29     A70     T7-1     B29     A70
  T5-1     B29     A76     T7-1     B29     A76
  T5-1     B29     A77     T7-1     B29     A77
  T5-1     B29     A78     T7-1     B29     A78
  T5-1     B29     A106     T7-1     B29     A106
                                     表26
  T5-1     B29     A110     T7-1     B29     A110
  T1-1     B30     A2     T2-1     B30     A2
  T1-1     B30     A5     T2-1     B30     A5
  T1-1     B30     A35     T2-1     B30     A35
  T1-1     B30     A37     T2-1     B30     A37
  T1-1     B30     A45     T2-1     B30     A45
  T1-1     B30     A46     T2-1     B30     A46
  T1-1     B30     A49     T2-1     B30     A49
  T1-1     B30     A54     T2-1     B30     A54
  T1-1     B30     A66     T2-1     B30     A66
  T1-1     B30     A67     T2-1     B30     A67
  T1-1     B30     A68     T2-1     B30     A68
  T1-1     B30     A69     T2-1     B30     A69
  T1-1     B30     A70     T2-1     B30     A70
  T1-1     B30     A76     T2-1     B30     A76
  T1-1     B30     A77     T2-1     B30     A77
  T1-1     B30     A78     T2-1     B30     A78
  T1-1     B30     A106     T2-1     B30     A106
  T1-1     B30     A110     T2-1     B30     A110
  T2-2     B30     A2     T2-3     B30     A2
  T2-2     B30     A5     T2-3     B30     A5
  T2-2     B30     A35     T2-3     B30     A35
  T2-2     B30     A37     T2-3     B30     A37
  T2-2     B30     A45     T2-3     B30     A45
  T2-2     B30     A46     T2-3     B30     A46
  T2-2     B30     A49     T2-3     B30     A49
  T2-2     B30     A54     T2-3     B30     A54
  T2-2     B30     A66     T2-3     B30     A66
  T2-2     B30     A67     T2-3     B30     A67
  T2-2     B30     A68     T2-3     B30     A68
  T2-2     B30     A69     T2-3     B30     A69
  T2-2     B30     A70     T2-3     B30     A70
  T2-2     B30     A76     T2-3     B30     A76
  T2-2     B30     A77     T2-3     B30     A77
  T2-2     B30     A78     T2-3     B30     A78
  T2-2     B30     A106     T2-3     B30     A106
  T2-2     B30     A110     T2-3     B30     A110
  T2-4     B30     A2     T2-5     B30     A2
  T2-4     B30     A5     T2-5     B30     A5
  T2-4     B30     A35     T2-5     B30     A35
  T2-4     B30     A37     T2-5     B30     A37
  T2-4     B30     A45     T2-5     B30     A45
  T2-4     B30     A46     T2-5     B30     A46
                                      表27
  T2-4     B30     A49     T2-5     B30     A49
  T2-4     B30     A54     T2-5     B30     A54
  T2-4     B30     A66     T2-5     B30     A66
  T2-4     B30     A67     T2-5     B30     A67
  T2-4     B30     A68     T2-5     B30     A68
  T2-4     B30     A69     T2-5     B30     A69
  T2-4     B30     A70     T2-5     B30     A70
  T2-4     B30     A76     T2-5     B30     A76
  T2-4     B30     A77     T2-5     B30     A77
  T2-4     B30     A78     T2-5     B30     A78
  T2-4     B30     A106     T2-5     B30     A106
  T2-4     B30     A110     T2-5     B30     A110
  T5-1     B30     A2     T7-1     B30     A2
  T5-1     B30     A5     T7-1     B30     A5
  T5-1     B30     A35     T7-1     B30     A35
  T5-1     B30     A37     T7-1     B30     A37
  T5-1     B30     A45     T7-1     B30     A45
  T5-1     B30     A46     T7-1     B30     A46
  T5-1     B30     A49     T7-1     B30     A49
  T5-1     B30     A54     T7-1     B30     A54
  T5-1     B30     A66     T7-1     B30     A66
  T5-1     B30     A67     T7-1     B30     A67
  T5-1     B30     A68     T7-1     B30     A68
  T5-1     B30     A69     T7-1     B30     A69
  T5-1     B30     A70     T7-1     B30     A70
  T5-1     B30     A76     T7-1     B30     A76
  T5-1     B30     A77     T7-1     B30     A77
  T5-1     B30     A78     T7-1     B30     A78
  T5-1     B30     A106     T7-1     B30     A106
  T5-1     B30     A110     T7-1     B30     A110
  T1-1     B31     A2     T2-1     B31     A2
  T1-1     B31     A5     T2-1     B31     A5
  T1-1     B31     A35     T2-1     B31     A35
  T1-1     B31     A37     T2-1     B31     A37
  T1-1     B31     A45     T2-1     B31     A45
  T1-1     B31     A46     T2-1     B31     A46
  T1-1     B31     A49     T2-1     B31     A49
  T1-1     B31     A54     T2-1     B31     A54
  T1-1     B31     A66     T2-1     B31     A66
  T1-1     B31     A67     T2-1     B31     A67
  T1-1     B31     A68     T2-1     B31     A68
  T1-1     B31     A69     T2-1     B31     A69
  T1-1     B31     A70     T2-1     B31     A70
                                      表28
  T1-1     B31     A76     T2-1     B31     A76
  T1-1     B31     A77     T2-1     B31     A77
  T1-1     B31     A78     T2-1     B31     A78
  T1-1     B31     A106     T2-1     B31     A106
  T1-1     B31     A110     T2-1     B31     A110
  T2-2     B31     A2     T2-3     B31     A2
  T2-2     B31     A5     T2-3     B31     A5
  T2-2     B31     A35     T2-3     B31     A35
  T2-2     B31     A37     T2-3     B31     A37
  T2-2     B31     A45     T2-3     B31     A45
  T2-2     B31     A46     T2-3     B31     A46
  T2-2     B31     A49     T2-3     B31     A49
  T2-2     B31     A54     T2-3     B31     A54
  T2-2     B31     A66     T2-3     B31     A66
  T2-2     B31     A67     T2-3     B31     A67
  T2-2     B31     A68     T2-3     B31     A68
  T2-2     B31     A69     T2-3     B31     A69
  T2-2     B31     A70     T2-3     B31     A70
  T2-2     B31     A76     T2-3     B31     A76
  T2-2     B31     A77     T2-3     B31     A77
  T2-2     B31     A78     T2-3     B31     A78
  T2-2     B31     A106     T2-3     B31     A106
  T2-2     B31     A110     T2-3     B31     A110
  T2-4     B31     A2     T2-5     B31     A2
  T2-4     B31     A5     T2-5     B31     A5
  T2-4     B31     A35     T2-5     B31     A35
  T2-4     B31     A37     T2-5     B31     A37
  T2-4     B31     A45     T2-5     B31     A45
  T2-4     B31     A46     T2-5     B31     A46
  T2-4     B31     A49     T2-5     B31     A49
  T2-4     B31     A54     T2-5     B31     A54
  T2-4     B31     A66     T2-5     B31     A66
  T2-4     B31     A67     T2-5     B31     A67
  T2-4     B31     A68     T2-5     B31     A68
  T2-4     B31     A69     T2-5     B31     A69
  T2-4     B31     A70     T2-5     B31     A70
  T2-4     B31     A76     T2-5     B31     A76
  T2-4     B31     A77     T2-5     B31     A77
  T2-4     B31     A78     T2-5     B31     A78
  T2-4     B31     A106     T2-5     B31     A106
  T2-4     B31     A110     T2-5     B31     A110
  T5-1     B31     A2     T7-1     B31     A2
  T5-1     B31     A5     T7-1     B31     A5
                                    表29
  T5-1     B31     A35     T7-1     B31     A35
  T5-1     B31     A37     T7-1     B31     A37
  T5-1     B31     A45     T7-1     B31     A45
  T5-1     B31     A46     T7-1     B31     A46
  T5-1     B31     A49     T7-1     B31     A49
  T5-1     B31     A54     T7-1     B31     A54
  T5-1     B31     A66     T7-1     B31     A66
  T5-1     B31     A67     T7-1     B31     A67
  T5-1     B31     A68     T7-1     B31     A68
  T5-1     B31     A69     T7-1     B31     A69
  T5-1     B31     A70     T7-1     B31     A70
  T5-1     B31     A76     T7-1     B31     A76
  T5-1     B31     A77     T7-1     B31     A77
  T5-1     B31     A78     T7-1     B31     A78
  T5-1     B31     A106     T7-1     B31     A106
  T5-1     B31     A110     T7-1     B31     A110
  T1-1     B32     A2     T2-1     B32     A2
  T1-1     B32     A5     T2-1     B32     A5
  T1-1     B32     A35     T2-1     B32     A35
  T1-1     B32     A37     T2-1     B32     A37
  T1-1     B32     A45     T2-1     B32     A45
  T1-1     B32     A46     T2-1     B32     A46
  T1-1     B32     A49     T2-1     B32     A49
  T1-1     B32     A54     T2-1     B32     A54
  T1-1     B32     A66     T2-1     B32     A66
  T1-1     B32     A67     T2-1     B32     A67
  T1-1     B32     A68     T2-1     B32     A68
  T1-1     B32     A69     T2-1     B32     A69
  T1-1     B32     A70     T2-1     B32     A70
  T1-1     B32     A76     T2-1     B32     A76
  T1-1     B32     A77     T2-1     B32     A77
  T1-1     B32     A78     T2-1     B32     A78
  T1-1     B32     A106     T2-1     B32     A106
  T1-1     B32     A110     T2-1     B32     A110
  T2-2     B32     A2     T2-3     B32     A2
  T2-2     B32     A5     T2-3     B32     A5
  T2-2     B32     A35     T2-3     B32     A35
  T2-2     B32     A37     T2-3     B32     A37
  T2-2     B32     A45     T2-3     B32     A45
  T2-2     B32     A46     T2-3     B32     A46
  T2-2     B32     A49     T2-3     B32     A49
  T2-2     B32     A54     T2-3     B32     A54
  T2-2     B32     A66     T2-3     B32     A66
                                     表30
  T2-2     B32     A67     T2-3     B32     A67
  T2-2     B32     A68     T2-3     B32     A68
  T2-2     B32     A69     T2-3     B32     A69
  T2-2     B32     A70     T2-3     B32     A70
  T2-2     B32     A76     T2-3     B32     A76
  T2-2     B32     A77     T2-3     B32     A77
  T2-2     B32     A78     T2-3     B32     A78
  T2-2     B32     A106     T2-3     B32     A106
  T2-2     B32     A110     T2-3     B32     A110
  T2-4     B32     A2     T2-5     B32     A2
  T2-4     B32     A5     T2-5     B32     A5
  T2-4     B32     A35     T2-5     B32     A35
  T2-4     B32     A37     T2-5     B32     A37
  T2-4     B32     A45     T2-5     B32     A45
  T2-4     B32     A46     T2-5     B32     A46
  T2-4     B32     A49     T2-5     B32     A49
  T2-4     B32     A54     T2-5     B32     A54
  T2-4     B32     A66     T2-5     B32     A66
  T2-4     B32     A67     T2-5     B32     A67
  T2-4     B32     A68     T2-5     B32     A68
  T2-4     B32     A69     T2-5     B32     A69
  T2-4     B32     A70     T2-5     B32     A70
  T2-4     B32     A76     T2-5     B32     A76
  T2-4     B32     A77     T2-5     B32     A77
  T2-4     B32     A78     T2-5     B32     A78
  T2-4     B32     A106     T2-5     B32     A106
  T2-4     B32     A110     T2-5     B32     A110
  T5-1     B32     A2     T7-1     B32     A2
  T5-1     B32     A5     T7-1     B32     A5
  T5-1     B32     A35     T7-1     B32     A35
  T5-1     B32     A37     T7-1     B32     A37
  T5-1     B32     A45     T7-1     B32     A45
  T5-1     B32     A46     T7-1     B32     A46
  T5-1     B32     A49     T7-1     B32     A49
  T5-1     B32     A54     T7-1     B32     A54
  T5-1     B32     A66     T7-1     B32     A66
  T5-1     B32     A67     T7-1     B32     A67
  T5-1     B32     A68     T7-1     B32     A68
  T5-1     B32     A69     T7-1     B32     A69
  T5-1     B32     A70     T7-1     B32     A70
  T5-1     B32     A76     T7-1     B32     A76
  T5-1     B32     A77     T7-1     B32     A77
  T5-1     B32     A78     T7-1     B32     A78
                                      表31
  T5-1     B32     A106     T7-1     B32     A106
  T5-1     B32     A110     T7-1     B32     A110
  T1-1     B33     A2     T2-1     B33     A2
  T1-1     B33     A5     T2-1     B33     A5
  T1-1     B33     A35     T2-1     B33     A35
  T1-1     B33     A37     T2-1     B33     A37
  T1-1     B33     A45     T2-1     B33     A45
  T1-1     B33     A46     T2-1     B33     A46
  T1-1     B33     A49     T2-1     B33     A49
  T1-1     B33     A54     T2-1     B33     A54
  T1-1     B33     A66     T2-1     B33     A66
  T1-1     B33     A67     T2-1     B33     A67
  T1-1     B33     A68     T2-1     B33     A68
  T1-1     B33     A69     T2-1     B33     A69
  T1-1     B33     A70     T2-1     B33     A70
  T1-1     B33     A76     T2-1     B33     A76
  T1-1     B33     A77     T2-1     B33     A77
  T1-1     B33     A78     T2-1     B33     A78
  T1-1     B33     A106     T2-1     B33     A106
  T1-1     B33     A110     T2-1     B33     A110
  T2-2     B33     A2     T2-3     B33     A2
  T2-2     B33     A5     T2-3     B33     A5
  T2-2     B33     A35     T2-3     B33     A35
  T2-2     B33     A37     T2-3     B33     A37
  T2-2     B33     A45     T2-3     B33     A45
  T2-2     B33     A46     T2-3     B33     A46
  T2-2     B33     A49     T2-3     B33     A49
  T2-2     B33     A54     T2-3     B33     A54
  T2-2     B33     A66     T2-3     B33     A66
  T2-2     B33     A67     T2-3     B33     A67
  T2-2     B33     A68     T2-3     B33     A68
  T2-2     B33     A69     T2-3     B33     A69
  T2-2     B33     A70     T2-3     B33     A70
  T2-2     B33     A76     T2-3     B33     A76
  T2-2     B33     A77     T2-3     B33     A77
  T2-2     B33     A78     T2-3     B33     A78
  T2-2     B33     A106     T2-3     B33     A106
  T2-2     B33     A110     T2-3     B33     A110
  T2-4     B33     A2     T2-5     B33     A2
  T2-4     B33     A5     T2-5     B33     A5
  T2-4     B33     A35     T2-5     B33     A35
  T2-4     B33     A37     T2-5     B33     A37
  T2-4     B33     A45     T2-5     B33     A45
                                    表32
  T2-4     B33     A46     T2-5     B33     A46
  T2-4     B33     A49     T2-5     B33     A49
  T2-4     B33     A54     T2-5     B33     A54
  T2-4     B33     A66     T2-5     B33     A66
  T2-4     B33     A67     T2-5     B33     A67
  T2-4     B33     A68     T2-5     B33     A68
  T2-4     B33     A69     T2-5     B33     A69
  T2-4     B33     A70     T2-5     B33     A70
  T2-4     B33     A76     T2-5     B33     A76
  T2-4     B33     A77     T2-5     B33     A77
  T2-4     B33     A78     T2-5     B33     A78
  T2-4     B33     A106     T2-5     B33     A106
  T2-4     B33     A110     T2-5     B33     A110
  T5-1     B33     A2     T7-1     B33     A2
  T5-1     B33     A5     T7-1     B33     A5
  T5-1     B33     A35     T7-1     B33     A35
  T5-1     B33     A37     T7-1     B33     A37
  T5-1     B33     A45     T7-1     B33     A45
  T5-1     B33     A46     T7-1     B33     A46
  T5-1     B33     A49     T7-1     B33     A49
  T5-1     B33     A54     T7-1     B33     A54
  T5-1     B33     A66     T7-1     B33     A66
  T5-1     B33     A67     T7-1     B33     A67
  T5-1     B33     A68     T7-1     B33     A68
  T5-1     B33     A69     T7-1     B33     A69
  T5-1     B33     A70     T7-1     B33     A70
  T5-1     B33     A76     T7-1     B33     A76
  T5-1     B33     A77     T7-1     B33     A77
  T5-1     B33     A78     T7-1     B33     A78
  T5-1     B33     A106     T7-1     B33     A106
  T5-1     B33     A110     T7-1     B33     A110
  T1-1     B34     A2     T2-1     B34     A2
  T1-1     B34     A5     T2-1     B34     A5
  T1-1     B34     A35     T2-1     B34     A35
  T1-1     B34     A37     T2-1     B34     A37
  T1-1     B34     A45     T2-1     B34     A45
  T1-1     B34     A46     T2-1     B34     A46
  T1-1     B34     A49     T2-1     B34     A49
  T1-1     B34     A54     T2-1     B34     A54
  T1-1     B34     A66     T2-1     B34     A66
  T1-1     B34     A67     T2-1     B34     A67
  T1-1     B34     A68     T2-1     B34     A68
  T1-1     B34     A69     T2-1     B34     A69
                                     表33
  T1-1     B34     A70     T2-1     B34     A70
  T1-1     B34     A76     T2-1     B34     A76
  T1-1     B34     A77     T2-1     B34     A77
  T1-1     B34     A78     T2-1     B34     A78
  T1-1     B34     A106     T2-1     B34     A106
  T1-1     B34     A110     T2-1     B34     A110
  T2-2     B34     A2     T2-3     B34     A2
  T2-2     B34     A5     T2-3     B34     A5
  T2-2     B34     A35     T2-3     B34     A35
  T2-2     B34     A37     T2-3     B34     A37
  T2-2     B34     A45     T2-3     B34     A45
  T2-2     B34     A46     T2-3     B34     A46
  T2-2     B34     A49     T2-3     B34     A49
  T2-2     B34     A54     T2-3     B34     A54
  T2-2     B34     A66     T2-3     B34     A66
  T2-2     B34     A67     T2-3     B34     A67
  T2-2     B34     A68     T2-3     B34     A68
  T2-2     B34     A69     T2-3     B34     A69
  T2-2     B34     A70     T2-3     B34     A70
  T2-2     B34     A76     T2-3     B34     A76
  T2-2     B34     A77     T2-3     B34     A77
  T2-2     B34     A78     T2-3     B34     A78
  T2-2     B34     A106     T2-3     B34     A106
  T2-2     B34     A110     T2-3     B34     A110
  T2-4     B34     A2     T2-5     B34     A2
  T2-4     B34     A5     T2-5     B34     A5
  T2-4     B34     A35     T2-5     B34     A35
  T2-4     B34     A37     T2-5     B34     A37
  T2-4     B34     A45     T2-5     B34     A45
  T2-4     B34     A46     T2-5     B34     A46
  T2-4     B34     A49     T2-5     B34     A49
  T2-4     B34     A54     T2-5     B34     A54
  T2-4     B34     A66     T2-5     B34     A66
  T2-4     B34     A67     T2-5     B34     A67
  T2-4     B34     A68     T2-5     B34     A68
  T2-4     B34     A69     T2-5     B34     A69
  T2-4     B34     A70     T2-5     B34     A70
  T2-4     B34     A76     T2-5     B34     A76
  T2-4     B34     A77     T2-5     B34     A77
  T2-4     B34     A78     T2-5     B34     A78
  T2-4     B34     A106     T2-5     B34     A106
  T2-4     B34     A110     T2-5     B34     A110
                                     表34
  T5-1     B34     A2     T7-1     B34     A2
  T5-1     B34     A5     T7-1     B34     A5
  T5-1     B34     A35     T7-1     B34     A35
  T5-1     B34     A37     T7-1     B34     A37
  T5-1     B34     A45     T7-1     B34     A45
  T5-1     B34     A46     T7-1     B34     A46
  T5-1     B34     A49     T7-1     B34     A49
  T5-1     B34     A54     T7-1     B34     A54
  T5-1     B34     A66     T7-1     B34     A66
  T5-1     B34     A67     T7-1     B34     A67
  T5-1     B34     A68     T7-1     B34     A68
  T5-1     B34     A69     T7-1     B34     A69
  T5-1     B34     A70     T7-1     B34     A70
  T5-1     B34     A76     T7-1     B34     A76
  T5-1     B34     A77     T7-1     B34     A77
  T5-1     B34     A78     T7-1     B34     A78
  T5-1     B34     A106     T7-1     B34     A106
  T5-1     B34     A110     T7-1     B34     A110
  T1-1     B35     A2     T2-1     B35     A2
  T1-1     B35     A5     T2-1     B35     A5
  T1-1     B35     A35     T2-1     B35     A35
  T1-1     B35     A37     T2-1     B35     A37
  T1-1     B35     A45     T2-1     B35     A45
  T1-1     B35     A46     T2-1     B35     A46
  T1-1     B35     A49     T2-1     B35     A49
  T1-1     B35     A54     T2-1     B35     A54
  T1-1     B35     A66     T2-1     B35     A66
  T1-1     B35     A67     T2-1     B35     A67
  T1-1     B35     A68     T2-1     B35     A68
  T1-1     B35     A69     T2-1     B35     A69
  T1-1     B35     A70     T2-1     B35     A70
  T1-1     B35     A76     T2-1     B35     A76
  T1-1     B35     A77     T2-1     B35     A77
  T1-1     B35     A78     T2-1     B35     A78
  T1-1     B35     A106     T2-1     B35     A106
  T1-1     B35     A110     T2-1     B35     A110
  T2-2     B35     A2     T2-3     B35     A2
  T2-2     B35     A5     T2-3     B35     A5
  T2-2     B35     A35     T2-3     B35     A35
  T2-2     B35     A37     T2-3     B35     A37
  T2-2     B35     A45     T2-3     B35     A45
  T2-2     B35     A46     T2-3     B35     A46
  T2-2     B35     A49     T2-3     B35     A49
                                    表35
  T2-2     B35     A54     T2-3     B35     A54
  T2-2     B35     A66     T2-3     B35     A66
  T2-2     B35     A67     T2-3     B35     A67
  T2-2     B35     A68     T2-3     B35     A68
  T2-2     B35     A69     T2-3     B35     A69
  T2-2     B35     A70     T2-3     B35     A70
  T2-2     B35     A76     T2-3     B35     A76
  T2-2     B35     A77     T2-3     B35     A77
  T2-2     B35     A78     T2-3     B35     A78
  T2-2     B35     A106     T2-3     B35     A106
  T2-2     B35     A110     T2-3     B35     A110
  T2-4     B35     A2     T2-5     B35     A2
  T2-4     B35     A5     T2-5     B35     A5
  T2-4     B35     A35     T2-5     B35     A35
  T2-4     B35     A37     T2-5     B35     A37
  T2-4     B35     A45     T2-5     B35     A45
  T2-4     B35     A46     T2-5     B35     A46
  T2-4     B35     A49     T2-5     B35     A49
  T2-4     B35     A54     T2-5     B35     A54
  T2-4     B35     A66     T2-5     B35     A66
  T2-4     B35     A67     T2-5     B35     A67
  T2-4     B35     A68     T2-5     B35     A68
  T2-4     B35     A69     T2-5     B35     A69
  T2-4     B35     A70     T2-5     B35     A70
  T2-4     B35     A76     T2-5     B35     A76
  T2-4     B35     A77     T2-5     B35     A77
  T2-4     B35     A78     T2-5     B35     A78
  T2-4     B35     A106     T2-5     B35     A106
  T2-4     B35     A110     T2-5     B35     A110
  T5-1     B35     A2     T7-1     B35     A2
  T5-1     B35     A5     T7-1     B35     A5
  T5-1     B35     A35     T7-1     B35     A35
  T5-1     B35     A37     T7-1     B35     A37
  T5-1     B35     A45     T7-1     B35     A45
  T5-1     B35     A46     T7-1     B35     A46
  T5-1     B35     A49     T7-1     B35     A49
  T5-1     B35     A54     T7-1     B35     A54
  T5-1     B35     A66     T7-1     B35     A66
  T5-1     B35     A67     T7-1     B35     A67
  T5-1     B35     A68     T7-1     B35     A68
  T5-1     B35     A69     T7-1     B35     A69
  T5-1     B35     A70     T7-1     B35     A70
  T5-1     B35     A76     T7-1     B35     A76
                                 表36
  T5-1     B35     A77     T7-1     B35     A77
  T5-1     B35     A78     T7-1     B35     A78
  T5-1     B35     A106     T7-1     B35     A106
  T5-1     B35     A110     T7-1     B35     A110
  T1-1     B36     A2     T2-1     B36     A2
  T1-1     B36     A5     T2-1     B36     A5
  T1-1     B36     A35     T2-1     B36     A35
  T1-1     B36     A37     T2-1     B36     A37
  T1-1     B36     A45     T2-1     B36     A45
  T1-1     B36     A46     T2-1     B36     A46
  T1-1     B36     A49     T2-1     B36     A49
  T1-1     B36     A54     T2-1     B36     A54
  T1-1     B36     A66     T2-1     B36     A66
  T1-1     B36     A67     T2-1     B36     A67
  T1-1     B36     A68     T2-1     B36     A68
  T1-1     B36     A69     T2-1     B36     A69
  T1-1     B36     A70     T2-1     B36     A70
  T1-1     B36     A76     T2-1     B36     A76
  T1-1     B36     A77     T2-1     B36     A77
  T1-1     B36     A78     T2-1     B36     A78
  T1-1     B36     A106     T2-1     B36     A106
  T1-1     B36     A110     T2-1     B36     A110
  T2-2     B36     A2     T2-3     B36     A2
  T2-2     B36     A5     T2-3     B36     A5
  T2-2     B36     A35     T2-3     B36     A35
  T2-2     B36     A37     T2-3     B36     A37
  T2-2     B36     A45     T2-3     B36     A45
  T2-2     B36     A46     T2-3     B36     A46
  T2-2     B36     A49     T2-3     B36     A49
  T2-2     B36     A54     T2-3     B36     A54
  T2-2     B36     A66     T2-3     B36     A66
  T2-2     B36     A67     T2-3     B36     A67
  T2-2     B36     A68     T2-3     B36     A68
  T2-2     B36     A69     T2-3     B36     A69
  T2-2     B36     A70     T2-3     B36     A70
  T2-2     B36     A76     T2-3     B36     A76
  T2-2     B36     A77     T2-3     B36     A77
  T2-2     B36     A78     T2-3     B36     A78
  T2-2     B36     A106     T2-3     B36     A106
  T2-2     B36     A110     T2-3     B36     A110
  T2-4     B36     A2     T2-5     B36     A2
  T2-4     B36     A5     T2-5     B36     A5
  T2-4     B36     A35     T2-5     B36     A35
                                      表37
  T2-4     B36     A37     T2-5     B36     A37
  T2-4     B36     A45     T2-5     B36     A45
  T2-4     B36     A46     T2-5     B36     A46
  T2-4     B36     A49     T2-5     B36     A49
  T2-4     B36     A54     T2-5     B36     A54
  T2-4     B36     A66     T2-5     B36     A66
  T2-4     B36     A67     T2-5     B36     A67
  T2-4     B36     A68     T2-5     B36     A68
  T2-4     B36     A69     T2-5     B36     A69
  T2-4     B36     A70     T2-5     B36     A70
  T2-4     B36     A76     T2-5     B36     A76
  T2-4     B36     A77     T2-5     B36     A77
  T2-4     B36     A78     T2-5     B36     A78
  T2-4     B36     A106     T2-5     B36     A106
  T2-4     B36     A110     T2-5     B36     A110
  T5-1     B36     A2     T7-1     B36     A2
  T5-1     B36     A5     T7-1     B36     A5
  T5-1     B36     A35     T7-1     B36     A35
  T5-1     B36     A37     T7-1     B36     A37
  T5-1     B36     A45     T7-1     B36     A45
  T5-1     B36     A46     T7-1     B36     A46
  T5-1     B36     A49     T7-1     B36     A49
  T5-1     B36     A54     T7-1     B36     A54
  T5-1     B36     A66     T7-1     B36     A66
  T5-1     B36     A67     T7-1     B36     A67
  T5-1     B36     A68     T7-1     B36     A68
  T5-1     B36     A69     T7-1     B36     A69
  T5-1     B36     A70     T7-1     B36     A70
  T5-1     B36     A76     T7-1     B36     A76
  T5-1     B36     A77     T7-1     B36     A77
  T5-1     B36     A78     T7-1     B36     A78
  T5-1     B36     A106     T7-1     B36     A106
  T5-1     B36     A110     T7-1     B36     A110
  T1-1     B37     A2     T2-1     B37     A2
  T1-1     B37     A5     T2-1     B37     A5
  T1-1     B37     A35     T2-1     B37     A35
  T1-1     B37     A37     T2-1     B37     A37
  T1-1     B37     A45     T2-1     B37     A45
  T1-1     B37     A46     T2-1     B37     A46
  T1-1     B37     A49     T2-1     B37     A49
  T1-1     B37     A54     T2-1     B37     A54
  T1-1     B37     A66     T2-1     B37     A66
  T1-1     B37     A67     T2-1     B37     A67
                                      表38
  T1-1     B37     A68     T2-1     B37     A68
  T1-1     B37     A69     T2-1     B37     A69
  T1-1     B37     A70     T2-1     B37     A70
  T1-1     B37     A76     T2-1     B37     A76
  T1-1     B37     A77     T2-1     B37     A77
  T1-1     B37     A78     T2-1     B37     A78
  T1-1     B37     A106     T2-1     B37     A106
  T1-1     B37     A110     T2-1     B37     A110
  T2-2     B37     A2     T2-3     B37     A2
  T2-2     B37     A5     T2-3     B37     A5
  T2-2     B37     A35     T2-3     B37     A35
  T2-2     B37     A37     T2-3     B37     A37
  T2-2     B37     A45     T2-3     B37     A45
  T2-2     B37     A46     T2-3     B37     A46
  T2-2     B37     A49     T2-3     B37     A49
  T2-2     B37     A54     T2-3     B37     A54
  T2-2     B37     A66     T2-3     B37     A66
  T2-2     B37     A67     T2-3     B37     A67
  T2-2     B37     A68     T2-3     B37     A68
  T2-2     B37     A69     T2-3     B37     A69
  T2-2     B37     A70     T2-3     B37     A70
  T2-2     B37     A76     T2-3     B37     A76
  T2-2     B37     A77     T2-3     B37     A77
  T2-2     B37     A78     T2-3     B37     A78
  T2-2     B37     A106     T2-3     B37     A106
  T2-2     B37     A110     T2-3     B37     A110
  T2-4     B37     A2     T2-5     B37     A2
  T2-4     B37     A5     T2-5     B37     A5
  T2-4     B37     A35     T2-5     B37     A35
  T2-4     B37     A37     T2-5     B37     A37
  T2-4     B37     A45     T2-5     B37     A45
  T2-4     B37     A46     T2-5     B37     A46
  T2-4     B37     A49     T2-5     B37     A49
  T2-4     B37     A54     T2-5     B37     A54
  T2-4     B37     A66     T2-5     B37     A66
  T2-4     B37     A67     T2-5     B37     A67
  T2-4     B37     A63     T2-5     B37     A68
  T2-4     B37     A69     T2-5     B37     A69
  T2-4     B37     A70     T2-5     B37     A70
  T2-4     B37     A76     T2-5     B37     A76
  T2-4     B37     A77     T2-5     B37     A77
  T2-4     B37     A78     T2-5     B37     A78
  T2-4     B37     A106     T2-5     B37     A106
                                        表39
  T2-4     B37     A110     T2-5     B37     A110
  T5-1     B37     A2     T7-1     B37     A2
  T5-1     B37     A5     T7-1     B37     A5
  T5-1     B37     A35     T7-1     B37     A35
  T5-1     B37     A37     T7-1     B37     A37
  T5-1     B37     A45     T7-1     B37     A45
  T5-1     B37     A46     T7-1     B37     A46
  T5-1     B37     A49     T7-1     B37     A49
  T5-1     B37     A54     T7-1     B37     A54
  T5-1     B37     A66     T7-1     B37     A66
  T5-1     B37     A67     T7-1     B37     A67
  T5-1     B37     A68     T7-1     B37     A68
  T5-1     B37     A69     T7-1     B37     A69
  T5-1     B37     A70     T7-1     B37     A70
  T5-1     B37     A76     T7-1     B37     A76
  T5-1     B37     A77     T7-1     B37     A77
  T5-1     B37     A78     T7-1     B37     A78
  T5-1     B37     A106     T7-1     B37     A106
  T5-1     B37     A110     T7-1     B37     A110
  T1-1     B38     A2     T2-1     B38     A2
  T1-1     B38     A5     T2-1     B38     A5
  T1-1     B38     A35     T2-1     B38     A35
  T1-1     B38     A37     T2-1     B38     A37
  T1-1     B38     A45     T2-1     B38     A45
  T1-1     B38     A46     T2-1     B38     A46
  T1-1     B38     A49     T2-1     B38     A49
  T1-1     B38     A54     T2-1     B38     A54
  T1-1     B38     A66     T2-1     B38     A66
  T1-1     B38     A67     T2-1     B38     A67
  T1-1     B38     A68     T2-1     B38     A68
  T1-1     B38     A69     T2-1     B38     A69
  T1-1     B38     A70     T2-1     B38     A70
  T1-1     B38     A76     T2-1     B38     A76
  T1-1     B38     A77     T2-1     B38     A77
  T1-1     B38     A78     T2-1     B38     A78
  T1-1     B38     A106     T2-1     B38     A106
  T1-1     B38     A110     T2-1     B38     A110
  T2-2     B38     A2     T2-3     B38     A2
  T2-2     B38     A5     T2-3     B38     A5
  T2-2     B38     A35     T2-3     B38     A35
  T2-2     B38     A37     T2-3     B38     A37
  T2-2     B38     A45     T2-3     B38     A45
  T2-2     B38     A46     T2-3     B38     A46
                                         表40
  T2-2     B38     A49     T2-3     B38     A49
  T2-2     B38     A54     T2-3     B38     A54
  T2-2     B38     A66     T2-3     B38     A66
  T2-2     B38     A67     T2-3     B38     A67
  T2-2     B38     A68     T2-3     B38     A68
  T2-2     B38     A69     T2-3     B38     A69
  T2-2     B38     A70     T2-3     B38     A70
  T2-2     B38     A76     T2-3     B38     A76
  T2-2     B38     A77     T2-3     B38     A77
  T2-2     B38     A78     T2-3     B38     A78
  T2-2     B38     A106     T2-3     B38     A106
  T2-2     B38     A110     T2-3     B38     A110
  T2-4     B38     A2     T2-5     B38     A2
  T2-4     B38     A5     T2-5     B38     A5
  T2-4     B38     A35     T2-5     B38     A35
  T2-4     B38     A37     T2-5     B38     A37
  T2-4     B38     A45     T2-5     B38     A45
  T2-4     B38     A46     T2-5     B38     A46
  T2-4     B38     A49     T2-5     B38     A49
  T2-4     B38     A54     T2-5     B38     A54
  T2-4     B38     A66     T2-5     B38     A66
  T2-4     B38     A67     T2-5     B38     A67
  T2-4     B38     A68     T2-5     B38     A68
  T2-4     B38     A69     T2-5     B38     A69
  T2-4     B38     A70     T2-5     B38     A70
  T2-4     B38     A76     T2-5     B38     A76
  T2-4     B38     A77     T2-5     B38     A77
  T2-4     B38     A78     T2-5     B38     A78
  T2-4     B38     A106     T2-5     B38     A106
  T2-4     B38     A110     T2-5     B38     A110
  T5-1     B38     A2     T7-1     B38     A2
  T5-1     B38     A5     T7-1     B38     A5
  T5-1     B38     A35     T7-1     B38     A35
  T5-1     B38     A37     T7-1     B38     A37
  T5-1     B38     A45     T7-1     B38     A45
  T5-1     B38     A46     T7-1     B38     A46
  T5-1     B38     A49     T7-1     B38     A49
  T5-1     B38     A54     T7-1     B38     A54
  T5-1     B38     A66     T7-1     B38     A66
  T5-1     B38     A67     T7-1     B38     A67
  T5-1     B38     A68     T7-1     B38     A68
  T5-1     B38     A69     T7-1     B38     A69
  T5-1     B38     A70     T7-1     B38     A70
                                       表41
  T5-1     B38     A76     T7-1     B38     A76
  T6-1     B38     A77     T7-1     B88     A77
  T5-1     B88     A78     T7-1     B38     A78
  T5-1     B38     A106     T7-1     B88     A106
  T5-1     B38     All0     T7-1     B38     A1lO
  T1-1     B89     A2     T2-1     B39     A2
  T1-1     B39     A5     T2-1     B39     A5
  T1-1     B39     A35     T2-1     B39     A35
  T1-1     B39     A87     T2-1     B39     A37
  T1-1     B39     A45     T2-1     B39     A45
  T1-1     B39     A46     T2-1     B89     A46
  T1-1     B89     A49     T2-1     B39     A49
  T1-1     B39     A54     T2-1     B39     A54
  T1-1     B39     A66     T2-1     B89     A66
  T1-1     B39     A67     T2-1     B39     A67
  T1-1     B39     A68     T2-1     B39     A68
  T1-1     B39     A69     T2-1     B39     A89
  T1-1     B39     A70     T2-1     B39     A70
  T1-1     B39     A76     T2-1     B39     A76
  T1-1     B39     A77     T2-1     B39     A77
  T1-1     B89     A78     T2-1     B39     A78
  T1-1     B39     A106     T2-1     B39     A106
  T1-1     B89     AllO     T2-1     B89     AllO
  T2-2     B89     A2     T2-3     B39     A2
  T2-2     B39     A5     T2-3     B39     A5
  T2-2     B39     A35     T2-3     B89     A35
  T2-2     B39     A37     T2-3     B39     A37
  T2-2     B39     A45     T2-3     B39     A45
  T2-2     B39     A46     T2-3     B39     A46
  T2-2     B39     A49     T2-3     B39     A49
  T2-2     B39     A54     T2-3     B39     A54
  T2-2     B89     A66     T2-3     B39     A66
  T2-2     B39     A67     T2-3     B39     A67
  T2-2     B39     A68     T2-3     B39     A68
  T2-2     B39     A69     T2-3     B39     A69
  T2-2     B39     A70     T2-3     B39     A70
  T2-2     B39     A76     T2-3     B39     A76
  T2-2     B39     A77     T2-3     B39     A77
  T2-2     B39     A78     T2-3     B39     A78
  T2-2     B89     A106     T2-3     B39     A106
  T2-2     B39     A110     T2-3     B39     A1lO
  T2-4     B39     A2     T2-5     B39     A2
                                       表42
  T2-4     B39     A5     T2-5     B39     A5
  T2-4     B39     A35     T2-5     B39     A35
  T2-4     B39     A37     T2-5     B39     A37
  T2-4     B39     A45     T2-5     B39     A45
  T2-4     B39     A46     T2-5     B39     A46
  T2-4     B39     A49     T2-5     B39     A49
  T2-4     B39     A54     T2-5     B39     A54
  T2-4     B39     A66     T2-5     B39     A66
  T2-4     B39     A67     T2-5     B39     A67
  T2-4     B39     A68     T2-5     B39     A68
  T2-4     B39     A69     T2-5     B39     A69
  T2-4     B39     A70     T2-5     B39     A70
  T2-4     B39     A76     T2-5     B39     A76
  T2-4     B39     A77     T2-5     B39     A77
  T2-4     B39     A78     T2-5     B39     A78
  T2-4     B39     A106     T2-5     B39     A106
  T2-4     B39     A110     T2-5     B39     A110
  T5-1     B39     A2     T7-1     B39  A2
  T5-1     B39     A5     T7-1     B39     A5
  T5-1     B39     A35     T7-1     B39     A35
  T5-1     B39     A37     T7-1     B39     A37
  T5-1     B39     A45     T7-1     B39     A45
  T5-1     B39     A46     T7-1     B39     A46
  T5-1     B39     A49     T7-1     B39     A49
  T5-1     B39     A54     T7-1     B39     A54
  T5-1     B39     A66     T7-1     B39     A66
  T5-1     B39     A67     T7-1     B39     A67
  T5-1     B39     A68     T7-1     B39     A68
  T5-1     B39     A69     T7-1     B39     A69
  T5-1     B39     A70     T7-1     B39     A70
  T5-1     B39     A76     T7-1     B39     A76
  T5-1     B39     A77     T7-1     B39     A77
  T5-1     B39     A78     T7-1     B39     A78
  T5-1     B39     A106     T7-1     B39     A106
  T5-1     B39     A110     T7-1     B39     A110
  T1-1     B40     A2     T2-1     B40     A2
  T1-1     B40     A5     T2-1     B40     A5
  T1-1     B40     A35     T2-1     B40     A35
  T1-1     B40     A37     T2-1     B40     A37
  T1-1     B40     A45     T2-1     B40     A45
  T1-1     B40     A46     T2-1     B40     A46
  T1-1     B40     A49     T2-1     B40     A49
                                    表43
  T1-1     B40     A54     T2-1     B40     A54
  T1-1     B40     A66     T2-1     B40     A66
  T1-1     B40     A67     T2-1     B40     A67
  T1-1     B40     A68     T2-1     B40     A68
  T1-1     B40     A69     T2-1     B40     A69
  T1-1     B40     A70     T2-1     B40     A70
  T1-1     B40     A76     T2-1     B40     A76
  T1-1     B40     A77     T2-1     B40     A77
  T1-1     B40     A78     T2-1     B40     A78
  T1-1     B40     A106     T2-1     B40     A106
  T1-1     B40     A110     T2-1     B40     A110
  T2-2     B40     A2     T2-3     B40     A2
  T2-2     B40     A5     T2-3     B40     A5
  T2-2     B40     A35     T2-3     B40     A35
  T2-2     B40     A37     T2-3     B40     A37
  T2-2     B40     A45     T2-3     B40     A45
  T2-2     B40     A46     T2-3     B40     A46
  T2-2     B40     A49     T2-3     B40     A49
  T2-2     B40     A54     T2-3     B40     A54
  T2-2     B40     A66     T2-3     B40     A66
  T2-2     B40     A67     T2-3     B40     A67
  T2-2     B40     A68     T2-3     B40     A68
  T2-2     B40     A69     T2-3     B40     A69
  T2-2     B40     A70     T2-3     B40     A70
  T2-2     B40     A76     T2-3     B40     A76
  T2-2     B40     A77     T2-3     B40     A77
  T2-2     B40     A78     T2-3     B40     A78
  T2-2     B40     A106     T2-3     B40     A106
  T2-2     B40     A110     T2-3     B40     A110
  T2-4     B40     A2     T2-5     B40     A2
  T2-4     B40     A5     T2-5     B40     A5
  T2-4     B40     A35     T2-5     B40     A35
  T2-4     B40     A37     T2-5     B40     A37
  T2-4     B40     A45     T2-5     B40     A45
  T2-4     B40     A46     T2-5     B40     A46
  T2-4     B40     A49     T2-5     B40     A49
  T2-4     B40     A54     T2-5     B40     A54
  T2-4     B40     A66     T2-5     B40     A66
  T2-4     B40     A67     T2-5     B40     A67
  T2-4     B40     A68     T2-5     B40     A68
  T2-4     B40     A69     T2-5     B40     A69
  T2-4     B40     A70     T2-5     B40     A70
                                         表44
  T2-4     B40     A76     T2-5     B40     A76
  T2-4     B40     A77     T2-5     B40     A77
  T2-4     B40     A78     T2-5     B40     A78
  T2-4     B40     A106     T2-5     B40     A106
  T2-4     B40     A110     T2-5     B40     A110
  T5-1     B40     A2     T7-1     B40     A2
  T5-1     B40     A5     T7-1     B40     A5
  T5-1     B40     A35     T7-1     B40     A35
  T5-1     B40     A37     T7-1     B40     A37
  T5-1     B40     A45     T7-1     B40     A45
  T5-1     B40     A46     T7-1     B40     A46
  T5-1     B40     A49     T7-1     B40     A49
  T5-1     B40     A54     T7-1     B40     A54
  T5-1     B40     A66     T7-1     B40     A66
  T5-1     B40     A67     T7-1     B40     A67
  T5-1     B40     A68     T7-1     B40     A68
  T5-1     B40     A69     T7-1     B40     A69
  T5-1     B40     A70     T7-1     B40     A70
  T5-1     B40     A76     T7-1     B40     A76
  T5-1     B40     A77     T7-1     B40     A77
  T5-1     B40     A78     T7-1     B40     A78
  T5-1     B40     A106     T7-1     B40     A106
  T5-1     B40     A110     T7-1     B40     A110
  T1-1     B41     A2     T2-1     B41     A2
  T1-1     B41     A5     T2-1     B41     A5
  T1-1     B41     A35     T2-1     B41     A35
  T1-1     B41     A37     T2-1     B41     A37
  T1-1     B41     A45     T2-1     B41     A45
  T1-1     B41     A46     T2-1     B41     A46
  T1-1     B41     A49     T2-1     B41     A49
  T1-1     B41     A54     T2-1     B41     A54
  T1-1     B41     A66     T2-1     B41     A66
  T1-1     B41     A67     T2-1     B41     A67
  T1-1     B41     A68     T2-1     B41     A68
  T1-1     B41     A69     T2-1     B41     A69
  T1-1     B41     A70     T2-1     B41     A70
  T1-1     B41     A76     T2-1     B41     A76
  T1-1     B41     A77     T2-1     B41     A77
  T1-1     B41     A78     T2-1     B41     A78
  T1-1     B41     A106     T2-1     B41     A106
  T1-1     B41     A110     T2-1     B41     A110
                                    表45
  T2-2     B41     A2     T2-3     B41     A2
  T2-2     B41     A5     T2-3     B41     A5
  T2-2     B41     A35     T2-3     B41     A35
  T2-2     B41     A37     T2-3     B41     A37
  T2-2     B41     A45     T2-3     B41     A45
  T2-2     B41     A46     T2-3     B41     A46
  T2-2     B41     A49     T2-3     B41     A49
  T2-2     B41     A54     T2-3     B41     A54
  T2-2     B41     A66     T2-3     B41     A66
  T2-2     B41     A67     T2-3     B41     A67
  T2-2     B41     A68     T2-3     B41     A68
  T2-2     B41     A69     T2-3     B41     A69
  T2-2     B41     A70     T2-3     B41     A70
  T2-2     B41     A76     T2-3     B41     A76
  T2-2     B41     A77     T2-3     B41     A77
  T2-2     B41     A78     T2-3     B41     A78
  T2-2     B41     A106     T2-3     B41     A106
  T2-2     B41     A110     T2-3     B41     A110
  T2-4     B41     A2     T2-5     B41     A2
  T2-4     B41     A5     T2-5     B41     A5
  T2-4     B41     A35     T2-5     B41     A35
  T2-4     B41     A37     T2-5     B41     A37
  T2-4     B41     A45     T2-5     B41     A45
  T2-4     B41     A46     T2-5     B41     A46
  T2-4     B41     A49     T2-5     B41     A49
  T2-4     B41     A54     T2-5     B41     A54
  T2-4     B41     A66     T2-5     B41     A66
  T2-4     B41     A67     T2-5     B41     A67
  T2-4     B41     A68     T2-5     B41     A68
  T2-4     B41     A69     T2-5     B41     A69
  T2-4     B41     A70     T2-5     B41     A70
  T2-4     B41     A76     T2-5     B41     A76
  T2-4     B41     A77     T2-5     B41     A77
  T2-4     B41     A78     T2-5     B41     A78
  T2-4     B41     A106     T2-5     B41     A106
  T2-4     B41     A110     T2-5     B41     A110
  T5-1     B41     A2     T7-1     B41     A2
  T5-1     B41     A5     T7-1     B41     A5
  T5-1     B41     A35     T7-1     B41     A35
  T5-1     B41     A37     T7-1     B41     A37
  T5-1     B41     A45     T7-1     B41     A45
  T5-1     B41     A46     T7-1     B41     A46
                                       表46
  T5-1     B41     A49     T7-1     B41     A49
  T5-1     B41     A54     T7-1     B41     A54
  T5-1     B41     A66     T7-1     B41     A66
  T5-1     B41     A67     T7-1     B41     A67
  T5-1     B41     A68     T7-1     B41     A68
  T5-1     B41     A69     T7-1     B41     A69
  T5-1     B41     A70     T7-1     B41     A70
  T5-1     B41     A76     T7-1     B41     A76
  T5-1     B41     A77     T7-1     B41     A77
  T5-1     B41     A78     T7-1     B41     A78
  T5-1     B41     A106     T7-1     B41     A106
  T5-1     B41     A110     T7-1     B41     A110
  T1-1     B42     A2     T2-1     B42     A2
  T1-1     B42     A5     T2-1     B42     A5
  T1-1     B42     A35     T2-1     B42     A35
  T1-1     B42     A37     T2-1     B42     A37
  T1-1     B42     A45     T2-1     B42     A45
  T1-1     B42     A46     T2-1     B42     A46
  T1-1     B42     A49     T2-1     B42     A49
  T1-1     B42     A54     T2-1     B42     A54
  T1-1     B42     A66     T2-1     B42     A66
  T1-1     B42     A67     T2-1     B42     A67
  T1-1     B42     A68     T2-1     B42     A68
  T1-1     B42     A69     T2-1     B42     A69
  T1-1     B42     A70     T2-1     B42     A70
  T1-1     B42     A76     T2-1     B42     A76
  T1-1     B42     A77     T2-1     B42     A77
  T1-1     B42     A78     T2-1     B42     A78
  T1-1     B42     A106     T2-1     B42     A106
  T1-1     B42     A110     T2-1     B42     A110
  T2-2     B42     A2     T2-3     B42     A2
  T2-2     B42     A5     T2-3     B42     A5
  T2-2     B42     A35     T2-3     B42     A35
  T2-2     B42     A37     T2-3     B42     A37
  T2-2     B42     A45     T2-3     B42     A45
  T2-2     B42     A46     T2-3     B42     A46
  T2-2     B42     A49     T2-3     B42     A49
  T2-2     B42     A54     T2-3     B42     A54
  T2-2     B42     A66     T2-3     B42     A66
  T2-2     B42     A67     T2-3     B42     A67
  T2-2     B42     A68     T2-3     B42     A68
  T2-2     B42     A69     T2-3     B42     A69
                                  表47
  T2-2     B42     A70     T2-3     B42     A70
  T2-2     B42     A76     T2-3     B42     A76
  T2-2     B42     A77     T2-3     B42     A77
  T2-2     B42     A78     T2-3     B42     A78
  T2-2     B42     A106     T2-3     B42     A106
  T2-2     B42     A110     T2-3     B42     A110
  T2-4     B42     A2     T2-5     B42     A2
  T2-4     B42     A5     T2-5     B42     A5
  T2-4     B42     A35     T2-5     B42     A35
  T2-4     B42     A37     T2-5     B42     A37
  T2-4     B42     A45     T2-5     B42     A45
  T2-4     B42     A46     T2-5     B42     A46
  T2-4     B42     A49     T2-5     B42     A49
  T2-4     B42     A54     T2-5     B42     A54
  T2-4     B42     A66     T2-5     B42     A66
  T2-4     B42     A67     T2-5     B42     A67
  T2-4     B42     A68     T2-5     B42     A68
  T2-4     B42     A69     T2-5     B42     A69
  T2-4     B42     A70     T2-5     B42     A70
  T2-4     B42     A76     T2-5     B42     A76
  T2-4     B42     A77     T2-5     B42     A77
  T2-4     B42     A78     T2-5     B42     A78
  T2-4     B42     A106     T2-5     B42     A106
  T2-4     B42     A110     T2-5     B42     A110
  T5-1     B42     A2     T7-1     B42     A2
  T5-1     B42     A5     T7-1     B42     A5
  T5-1     B42     A35     T7-1     B42     A35
  T5-1     B42     A37     T7-1     B42     A37
  T5-1     B42     A45     T7-1     B42     A45
  T5-1     B42     A46     T7-1     B42     A46
  T5-1     B42     A49     T7-1     B42     A49
  T5-1     B42     A54     T7-1     B42     A54
  T5-1     B42     A68     T7-1     B42     A66
  T5-1     B42     A67     T7-1     B42     A67
  T5-1     B42     A68     T7-1     B42     A68
  T5-1     B42     A69     T7-1     B42     A69
  T5-1     B42     A70     T7-1     B42     A70
  T5-1     B42     A76     T7-1     B42     A76
  T5-1     B42     A77     T7-1     B42     A77
  T5-1     B42     A78     T7-1     B42     A78
  T5-1     B42     A106     T7-1     B42     A106
  T5-1     B42     A110     T7-1     B42     A110
                                     表48
  T1-1     B43     A2     T2-1     B43     A2
  T1-1     B43     A5     T2-1     B43     A5
  T1-1     B43     A35     T2-1     B43     A35
  T1-1     B43     A37     T2-1     B43     A37
  T1-1     B43     A45     T2-1     B43     A45
  T1-1     B43     A46     T2-1     B43     A46
  T1-1     B43     A49     T2-1     B43     A49
  T1-1     B43     A64     T2-1     B43     A54
  T1-1     B43     A66     T2-1     B43     A66
  T1-1     B43     A67     T2-1     B43     A67
  T1-1     B43     A68     T2-1     B43     A68
  T1-1     B43     A69     T2-1     B43     A69
  T1-l     B43     A70     T2-1     B43     A70
  T1-1     B43     A76     T2-1     B43     A76
  T1-1     B43     A77     T2-1     B43     A77
  T1-1     B43     A78     T2-1     B43     A78
  T1-1     B43     A106     T2-1     B43     A106
  T1-1     B43     A110     T2-1     B43     A1lO
  T2-2     B43     A2     T2-3     B48     A2
  T2-2     B43     A5     T2-3     B43     A5
  T2-2     B43     A35     T2-3     B43     A35
  T2-2     B43     A37     T2-3     B43     A37
  T2-2     B43     A45     T2-3     B48     A45
  T2-2     B43     A46     T2-3     B43     A4B
  T2-2     B48     A49     T2-3     B43     A49
  T2-2     B43     A54     T2-3     B43     A54
  T2-2     B43     A66     T2-3     B43     A66
  T2-2     B43     A67     T2-3     B43     A67
  T2-2     B43     A68     T2-8     B43     A68
  T2-2     B43     A69     T2-3     B43     A69
  T2-2     B43     A70     T2-3     B43     A70
  T2-2     B43     A76     T2-3     B43     A76
  T2-2     B43     A11     T2-3     B43     A77
  T2-2     B43     A78     T2-3     B43     A78
  T2-2     B43     A106     T2-8     B43     A106
  T2-2     B43     AllO     T2-3     B43     A110
  T2-4     B43     A2     T2-5     B43     A2
  T2-4     B43     A5     T2-5     B43     A5
  T2-4     B43     A35     T2-5     B43     A35
  T2-4     B43     A37     T2-5     B43     A37
  T2-4     B43     A45     T2-5     B43     A45
  T2-4     B43     A46     T2-5     B43     A46
                                    表49
  T2-4     B43     A49     T2-5     B43     A49
  T2-4     B43     A54     T2-5     B43     A54
  T2-4     B43     A66     T2-5     B43     A66
  T2-4     B43     A67     T2-5     B43     A67
  T2-4     B43     A68     T2-5     B43     A68
  T2-4     B43     A69     T2-5     B43     A69
  T2-4     B43     A70     T2-5     B43     A70
  T2-4     B43     A76     T2-5     B43     A76
  T2-4     B43     A77     T2-5     B43     A77
  T2-4     B43     A78     T2-5     B43     A78
  T2-4     B43     A106     T2-5     B43     A106
  T2-4     B43     A110     T2-5     B43     A110
  T5-1     B43     A2     T7-1     B43     A2
  T5-1     B43     A5     T7-1     B43     A5
  T5-1     B48     A35     T7-1     B43     A35
  T5-1     B43     A37     T7-1     B43     A37
  T5-1     B43     A45     T7-1     B43     A45
  T5-1     B43     A46     T7-1     B43     A46
  T5-1     B43     A49     T7-1     B43     A49
  T5-1     B43     A54     T7-1     B43     A54
  T5-1     B43     A66     T7-1     B43     A66
  T5-1     B43     A67     T7-1     B43     A67
  T5-1     B43     A68     T7-1     B43     A68
  T5-1     B43     A69     T7-1     B43     A69
  T5-1     B43     A70     T7-1     B43     A70
  T5-1     B43     A76     T7-1     B43     A76
  T5-1     B43     A77     T7-1     B43     A77
  T5-1     B43     A78     T7-1     B43     A78
  T5-1     B43     A106     T7-1     B43     A106
  T5-1     B43     A110     T7-1     B43     A110
此外，优选具有上述结构的化合物，其中-X’-Y’选自下列基团之一：OCH2CH=CMe2、OCH2-2-呋喃基、OCH2-3-呋喃基、OCH2C≡CMe、NHCH2CH=CMe2、N(iPr)SO2NHMe、NHCH(Me)CH2OMe、NH异丙基、NH-异丁基、NH环戊基、NHCH2环己基、NH环己基、NH环己基-4-(=NOMe)、NH环己基-4,4-(OMe)2、NHCH2C6H4-4-B(OH)2、NHCH2C6H4-2-OH、NHCH2C6H3-3,4-(OH)2、NHCH2C6H2-3,4,5-(OMe)3、NHCH2C6H4-4-COOH、NHCH2C6H4-4-OH、NHCH2C6H4-3-OH、NHCH2-2-呋喃基、NHCH2-3-呋喃基、NH-4-四氢吡喃、NHCH2-苯并吡咯基、NHCH2-2-噻唑基、NHCH2-喹啉基、NH环己基-4,4-亚乙基二氧基、1-吡咯烷基、4-吗啉基、1-piperadinyl、4-硫代吗啉基、1-哌啶基、其中-X’-Y’为-OCH2-2-呋喃基、-NHCH2CH=CMe2或-OCH2CH=CMe2的化合物是更优选的。
制备化合物(Ⅰ)的方法如下。制备化合物(Ⅰ’)的方法
下式(Ⅰ’)的化合物(此后称作“化合物(Ⅰ’)”)可通过使式(Ⅱa)化合物(此后称作“化合物(Ⅱa)”)与式(Ⅲa)的二环化合物(此后称作“化合物(Ⅲa)”)反应，或通过使式(Ⅱb)化合物(此后称作“化合物(Ⅱb)”)与式(Ⅲb)的二环化合物(此后称作“化合物(Ⅲb)”)反应来制备，
Figure 9980434501492
其中L和Z中的任一个为二羟基硼烷、二(低级)烷基硼烷或二(低级)烷氧基硼烷，而另一个为卤素或-OSO2(CqF2q+1)(q是0-4的整数)，其它符号与如上定义相同。
化合物(Ⅰ’)可以通过使化合物(Ⅱa)与化合物(Ⅲa)或使化合物(Ⅱb)与化合物(Ⅲb)在下列条件下反应制备：于室温下或加热数十分钟至数十小时，在合适的溶剂如苯、甲苯、N,N-二甲基甲酰胺、二甲氧基乙烷、四氢呋喃、二氧六环、乙醇、甲醇等和水的混合物中，或在无水溶液中，在钯催化剂如Pd(PPh3)4、PdCl2(PPh3)2、PdCl2(OAc)2、PdCl2(CH3CN)2等，优选Pd(PPh3)4存在下，在碱性条件下(例如磷酸钾、碳酸氢钠、NaOEt、碳酸钠、Et4NCl、氢氧化钡、Cs2CO3、CsF、氢氧化钠、碳酸银等)。
要进行反应的化合物的取代基L和Z中之一可以为能用于Suzuki反应(化学通讯1979,866,合成有机化学杂志，日本，1993,51卷，11期，91-100)的任何硼烷基团，优选二羟基硼烷。另一个可以为能用于Suzuki反应的任何离去基团，例如卤素、-OSO2(CqF2q+1)，其中q是0-4的整数，等等。特别优选卤素、三氟甲磺酰基氧基(此后称作OTf)等，更优选溴、碘或OTf。
化合物(Ⅱa)、(Ⅲa)、(Ⅱb)和(Ⅲb)的A环、B环和C环以及-X-Y的其它取代基可以是不影响Suzuki反应的任何基团，例如除卤素和-OSO2(CqF2q+1)(其中q是0-4的整数)外的任何基团。
例如，Y可为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的酰基、任选取代的环烷基、任选取代的环烯基、任选取代的芳基或可与苯环稠合的任选取代的5-或6-元杂环，当X是-CH2-时，Y可以为任选取代的低级烷氧基，当X是-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基。
当取代基L与取代基Z的反应性高于卤素与取代基L和Z中的任一个的反应性时，即使A环、B环或C环的任何取代基为卤素，这些反应可以毫无困难地进行。
即使A环、B环和C环或-X-Y的取代基为羟基时，也优选进行上述反应。优选上述反应可在用通常的羟基-保护基团，如甲氧基甲基、苄基、叔丁基二甲基甲硅烷基、甲磺酰基、对甲苯磺酰基等保护羟基后进行，接着通过常规方法去保护。
至于制备化合物(Ⅰ’)的方法，根据反应的效率和容易程度，最优选上述Suzuki反应，但用硅、锌、锡等代替上述流程中的硼烷基。
例如，在A和Z之一为-SiR17 3-r(Hal)r(其中R17独立为低级烷基，Hal为卤素和r为1-3的整数)，而另一个为卤素或-OSO2(CqF2q+1)(其中q是0-4的整数)的情况下，可以使用常规的钯催化剂进行偶合反应(Synlett(1991)845-853，有机化学杂志1996,61,7232-7233)。优选的钯催化剂的实例有(i-Pr3P)2PdCl2、[(dcpe)PdCl2](dcpe=Cy2PCH2CH2PCy2)、(η3·C3H5PdCl)2等。
即使在L和Z之一为-SnR18 3(其中R18每个独立为低级烷基)，而另一个为卤素、乙酰氧基或-OSO2(CqF2q+1)(其中q是0-4的整数)的情况下，使用常规的钯催化剂(优选Pd(PPh3)4等)可以获得目标化合物(Angew.Chem.Int.Ed.Engl.25(1986)508-524)。
在L和Z之一为-Zn(Hal)(其中Hal为卤素)，而另一个为卤素的情况下，可以获得目标化合物(Acc.Chem.Res.1982,15,340-348)。可使用任何常规的钯催化剂，优选的实例有Pd(PPh3)4、PdCl2(dppf)、PdCl2(PPh3)2、PdCl2(P(o-甲苯基)3)2、Pd(OAc)2等。
所有这些反应都可于室温下或加热数十分钟至数十小时的条件下，在合适的溶剂，如N,N-二甲基甲酰胺、四氢呋喃等中进行。
可以使用已知的化合物或衍生自下式(Ⅴa)化合物(此后称作“化合物(Ⅴa)”)或下式(Ⅴb)化合物(此后称作“化合物(Ⅴb)”)的化合物作为上述反应中的化合物(Ⅲa)和(Ⅲb)，所述式(Ⅴa)和式(Ⅴb)化合物可通过已知的方法或以下方法制备：其中D是不影响L与Z的Suzuki反应的任何基团，且当式(Ⅳb)化合物为双对称化合物时，D可以为与L相同的基团。其它符号与上述相同。
化合物(Ⅱb)与化合物(Ⅳa)反应或化合物(Ⅱa)与化合物(Ⅳb)反应得到化合物(Ⅴa)或(Ⅴb)。当式(Ⅳa)或式(Ⅳb)化合物不是双对称化合物时，D优选为不影响L与Z的Suzuki反应的基团，并且可容易地转化为L。例如，羟基、氢、甲酰基、硝基等是优选的。在L与Z的反应中，可以使用硅、锌、锡等代替上述的硼烷基。
可将D转化为可用于Suzuki反应的基团L。
于-20℃或加热数分钟至数十小时的条件下，在碱如氢化钠、吡啶、三乙胺、碳酸钾等存在下，在合适的溶剂如二氯甲烷、氯仿、四氢呋喃或苯中，其中D为羟基的化合物可以与三氟甲磺酰化剂，例如三氟甲磺酸酐、三氟甲磺酰氯、N-苯基三氟甲磺酰亚胺(sulfone imide)等反应得到其中L为OTf的目标化合物。
例如，于-20℃或加热数分钟至数十小时的条件下，在合适的溶剂如乙酸、二氯甲烷、氯仿、四氯化碳、苯、水等中，其中D为氢的化合物可以与卤化剂，例如溴、氯、碘、N-溴代琥珀亚酰胺等反应得到其中L为卤素的目标化合物。
其中D为甲酰基的化合物可经Baeyer-Villiger反应氧化得到其中D为甲酰基氧基的化合物，接着水解得到其中D为羟基的化合物。其中L为OTf的化合物可通过如以上提及的类似的方法获得。
其中D为硝基的化合物可还原为其中D为氨基的化合物，接着经Sandmeyer反应得到其中L为卤素的化合物。制备化合物(Ⅰ”)的方法
下式(Ⅰ”)的化合物(此后称作“化合物(Ⅰ”)”)可通过使式(Ⅵ)化合物(此后称作“化合物(Ⅵ)”)与式(Ⅱa)化合物(此后称作“化合物(Ⅱa)”)的Suzuki反应，或通过使式(Ⅶ)化合物(此后称作“化合物(Ⅶ)”)与式(Ⅷ)化合物(此后称作“化合物(Ⅷ)”)的缩合来制备：
Figure 9980434501531
其中M和Q中的任一个为羟基或氨基，而另一个为卤素、低级烷基磺酰基氧基、芳基磺酰基氧基、低级烷基磺酰基、芳基磺酰基或含有上述基团作为取代基的甲基，M和Q中之一为锂或Mg(Hal)，其中Hal为卤素，而另一个为羧基、低级烷氧基羰基、氨基甲酰基或甲酰基，M和Q之一为甲酰基，而另一个为卤代甲基，或M和Q之一为乙炔基，而另一个为卤素；其它符号与如上定义相同。
化合物(Ⅵ)与化合物(Ⅱa)反应的各种条件与制备化合物(Ⅰ’)的方法的条件相同。
在化合物(Ⅶ)与化合物(Ⅷ)的反应中，当目标化合物的V2为-O-、-NH-、-OCH2-、-CH2O-或-NHCH2-时，M和Q中的一个为羟基或氨基，而另一个为离去基团如卤素、低级烷基磺酰基氧基、芳基磺酰基氧基、低级烷基磺酰基、芳基磺酰基等或具有离去基团作为取代基的甲基。这两种化合物在合适的溶剂如苯、甲苯、丙酮、乙腈、N,N-二甲基甲酰胺、二甲亚矾、吡啶、甲醇、乙醇等中，在碱如氢化钠、吡啶、三乙胺、碳酸钾、氢氧化钠、氢氧化钾等(如果需要，加入铜催化剂如铜粉、氯化亚铜、氧化铜等)存在下反应，于0℃或加热数分钟至数十小时，得到目标化合物。
在化合物(Ⅶ)与化合物(Ⅷ)的反应中，当目标化合物的V2为-CO-或-CH(OH)-时，M和Q中的一个为有机金属如锂或Mg(Hal)，其中Hal为卤素，而另一个为羧基、低级烷氧基羰基、氨基甲酰基或甲酰基。这两种化合物在合适的溶剂如乙醚、四氢呋喃、二甲氧基乙烷、二氧六环等中，于-78℃或加热数分钟至数十小时反应，得到目标化合物。
当目标化合物的V2为-CH(OR)-时，其中R为低级烷基，在获得其中V2为-CH(OH)-的化合物后，可使获得的化合物经烷基化作用。
其中V2为-CO-的化合物可以通过其中V2为-CH(OH)-的化合物与氧化剂如铬酐、Jone’s试剂等在诸如叔丁醇、丙酮等的溶剂(取决于氧化剂)中反应(于0℃或加热数十小时)而获得。其中V2为-CH(OH)-的化合物可以通过其中V2为-CO-的化合物与还原剂如硼氢化钠、氢化铝锂等在诸如乙醚、四氢呋喃、二甲氧基乙烷、二氧六环、甲醇、乙醇等的合适溶剂中反应而获得。
当目标化合物的V2为-CH=CH-的化合物时，M和Q中的一个为甲酰基，而另一个为卤代甲基(例如卤素为氯代、溴代或碘代)。通过Wittig反应(有机反应，14卷，270页，1965)可以得到目标化合物。
当目标化合物的V2为-CH≡CH-时，M和Q中的一个为乙炔基，而另一个为卤素(优选溴代或或碘代)。通过一般使用钯催化剂的偶合反应(例如，合成反应，(1980)627，四面体，1982,38,631)可以合成目标化合物。
化合物(Ⅵ)、(Ⅱa)、(Ⅶ)和(Ⅷ)的A环、B环、C环以及-X-Y的其它取代基可以是不影响L与Z的Suzuki反应或M与Q的缩合反应的任何取代基。即使在化合物(Ⅵ)与其中任一取代基为卤素的化合物(Ⅱa)的反应中，如果取代基L与取代基Z的反应性高于与卤素的反应性时，该反应可以毫无困难地进行。即使任一取代基为羟基时，上面的反应也可以进行。优选在此之前保护羟基，接着在上述反应后去保护。
至于上面流程中的化合物(Ⅵ)，可以使用已知的化合物或用下面的方法合成的式(Ⅹ)化合物：
Figure 9980434501541
其中D’是不影响M与Q的缩合反应的基团，当式(Ⅸ)化合物是不对称化合物时，D’可以为如同Q的基团，其它符号与上述定义相同。
当式(Ⅸ)化合物不是对称化合物时，D’优选为不影响M与Q的缩合反应的且可容易地转化为L的基团。例如，氢、甲酰基、保护的羟基、硝基等是优选的。羟基保护基团的实例有苄基、叔丁基二甲基甲硅烷基、甲氧基甲基等。将D’转化为L的方法类似于上面的将D转化为L的方法。其它各种条件与化合物(Ⅶ)与化合物(Ⅷ)的反应条件相似。
可以使用已知的化合物作为上述反应流程中的化合物(Ⅷ)，也可以使用通过已知的方法合成的或经常规方法衍生自上面化合物(Vb)的化合物。
在化合物具有干扰以上反应的取代基的情况下，该取代基可以提前用合适的保护基团保护，该保护基团可在合适的步骤中，通过常规方法除去。例如，如果羟基干扰该反应，可以用甲氧基甲基、甲磺酰基、苄基、三氟甲磺酰基、叔丁基二甲基甲硅烷基等对其进行保护，随后在合适的步骤中除去。
例如，对于用甲磺酰基保护羟基来说，可以在碱如三乙胺、吡啶等存在下，在诸如二氯甲烷、氯仿、四氯化碳等溶剂中，使具有羟基的化合物与甲磺酰氯在冰冷或室温下反应数小时。于室温或加热数十分钟至数十小时的条件下，在诸如二甲亚砜、二甲基甲酰胺、四氢呋喃、二氧六环、二甲氧基乙烷等溶剂中，用1-4N氢氧化钠、氢氧化钾、其水溶液、甲醇钠、乙基溴化镁等使被保护的化合物去保护。
当使用甲氧基甲基作为羟基保护基团时，可以在氢化钠、二异丙基乙胺等存在下，在诸如四氢呋喃、二氧六环、二甲氧基乙烷等溶剂中，使具有羟基的化合物与氯代甲基甲醚反应，得到具有保护的羟基的化合物。使该化合物与盐酸、硫酸等在诸如甲醇、四氢呋喃、乙酸等溶剂中经受常规的去保护反应脱去保护。
当使用叔丁基二甲基甲硅烷基作为保护基团时，可以在咪唑、三乙胺、2,6-二甲基吡啶等存在下，在诸如二甲基甲酰胺、乙腈、四氢呋喃、二甲基甲酰胺、二氯甲烷等溶剂中，使具有羟基的化合物与叔丁基二甲基甲硅烷基氯、叔丁基二甲基甲硅烷基三氟甲磺酸酯等反应。对于去保护反应来说，被保护的化合物可以与四丁基氟化铵等在溶剂如四氢呋喃等中反应。
如此获得的本发明化合物可以转化为其前药。术语“前药”包括在活体内能容易地转化为具有本发明活性的化合物的化合物。可以使用任何常规的转化为前药的方法。
例如，连接于本发明化合物的任何可能的位置上的羟基或氨基可以用通常的基团取代，以制备前药。例如，取代的酰基(其中所述取代基为羧基、磺基、氨基、低级烷基氨基等)、膦酰氧基等可以被引入羟基，而取代的烷氧基羰基(其中所述取代基为卤素、酰氧基、羟基乙酰氧基、羧基乙酰氧基、杂环羰基氧基等)或取代的烷基(其中所述取代基为可由酰氧基(低级)烷氧基等取代的芳酰基氨基)可以被引入氨基。
更加确定的是，当A环或C环具有羟基作为取代基时，可以引入诸如-COCH2CH2COOH、-COCH=CHCOOH、-COCH2SO3H、-PO3H2、-COCH2NMe2、-CO-Py，其中Py为吡啶等的取代基。当A环或C环具有氨基作为取代基(如X,X’等)时，可以引入-COOCH2O(C=O)CH2OH、-COOCH2O(C=O)CH2CH2COOH、-COOCH2OAc、-COOCH(Me)OAc、-COOCH(Me)OCOCMe3、-COOCH2OCO(CH2)14Me、COOCH2OCO-Pyr、CH2NHCO-C6H4-o-OCH2OAc等的取代基。
本发明的免疫抑制剂或抗过敏药物用于预防或治疗针对器官或组织移植的排斥症状，因骨髓移植引起的移植物对宿主反应、特应性过敏性疾病(如支气管哮喘、过敏性鼻炎、过敏性皮炎等)、嗜酸细胞增多综合征、过敏性结膜炎、系统性红斑狼疮、多肌炎、皮肌炎、睑硬结、MCTD、慢性类风湿性关节炎、炎性肠道疾病、因缺血性再灌注引起的损伤、枯草热、过敏性鼻炎、荨麻疹、牛皮癣等。
本发明化合物可作为免疫抑制剂、抗过敏剂和/或IgE产生的抑制剂口服或胃肠外给予。在口服给予的情况下，它可以为任何常用的形式，例如片剂、颗粒、散剂、胶囊、丸剂、溶液、糖浆剂、颊下含片、舌下含片等。当该化合物为胃肠外给药时，优选任何常用的形式，例如注射剂(如静脉内、肌内)、栓剂、透皮剂、气雾剂等。特别优选口服给药。
通过将有效量的本发明化合物与各种适合于给予形式的药用组分(如赋形剂、粘合剂、湿润剂、崩解剂、润滑剂、稀释剂等)混合，可以制备药用组合物。当该组合物为注射剂时，可以用合适的载体对活性组分灭菌，以得到药用组合物。
赋形剂的具体实例包括乳糖、蔗糖、葡萄糖、淀粉、碳酸钙、结晶纤维素等，粘合剂的实例包括甲基纤维素、羧甲基纤维素、羟丙基纤维素、明胶、聚乙烯吡咯烷酮等，崩解剂的实例包括羧甲基纤维素、羧甲基纤维素钠、淀粉、藻酸钠、琼脂、十二烷基硫酸钠等，润滑剂的实例包括滑石、硬脂酸镁、大粒凝胶(macrogol)等。可可油、大粒凝胶、甲基纤维素等可被用作栓剂的基质材料。当将该组合物制备为溶液、乳化的注射液或悬浮的注射液时，可以加入助溶剂、悬浮剂、乳化剂、稳定剂、防腐剂、等渗剂等。对于口服给药，可以加入甜味剂、调味剂等。
尽管本发明化合物作为免疫抑制剂、抗过敏剂和/或IgE产生的抑制剂的剂量应当考虑病人的年龄和体重、疾病的类型及程度、给药途径等因素来决定，但对于成人的常规口服剂量为0.05-100mg/kg天，优选0.1-10mg/kg/天。对于胃肠外给药，虽然剂量随给药途径变化很大，但通常的剂量为0.005-10mg/kg/天，优选0.01-1mg/kg/天。该剂量可以每天给予一次或分几次给予。
通过下列实施例和实验进一步说明本发明，但这些实施例和实验并不限制本发明的范围。
实施例
实施例中所用的缩写意思如下，
Ac        乙酰基
Bn        苄基
Et        乙基
iPr       异丙基
Me        甲基
Ms        甲磺酰基
Ph        苯基
Py        吡啶基
TBS       叔丁基二甲基甲硅烷基
TFAA      三氟乙酸酐
THF        四氢呋喃
实施例1化合物(Ⅰa-71)、(Ⅰa-73)、(Ⅰa-75)和(Ⅰa-76)的合成(步骤1)化合物(2)的合成
于室温下，向831mg(2.32mmol)化合物(1)(WO98/04508，参考实施例1)在12ml甲苯中的溶液中加入701mg(2.79mmol)2,5-二溴-3-甲基吡啶、80mg(0.07mmol)四(三苯膦)钯(0)和6mg 2M的碳酸钠水溶液。在氮气环境下，将该混合物加热至回流4小时。冷却后，用水稀释该混合物并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙基97∶3)，得到化合物(2)(808mg，收率60％)。(步骤2)化合物(4)的合成
根据步骤1的方法，使404mg(0.83mmol)化合物(2)与231mg(0.92mmol)硼酸(3)(GB2276162A)反应，得到化合物(4)(411mg，收率81％)。(步骤3)化合物(Ⅰa-71)的合成
于室温下，向411mg(0.67mmol)化合物(4)在3.4ml四氢呋喃中的溶液中加入1M四丁基氟化铵在1.4ml(1.40mmol)四氢呋喃中的溶液，搅拌该混合物3小时。将该溶液倾入5％的硫酸氢钾水溶液中并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥并浓缩。残留物经从乙酸乙酯中结晶得到化合物(Ⅰa-71)(247mg，收率96％)。(步骤4)化合物(Ⅰa-75)的合成
于室温下，向227mg(0.59mmol)化合物(Ⅰa-71)在3ml四氢呋喃中的溶液中顺序加入0.17ml(1.18mmol)三乙胺和0.07ml(0.89mmol)甲磺酰氯，搅拌该混合物20小时。用乙酸乙酯稀释该溶液，用水、5％的碳酸氢钠水溶液和饱和盐水顺序洗涤，干燥并浓缩。残留物经从己烷-乙酸乙酯中结晶得到化合物(Ⅰa-75)(303mg，收率95％)。(步骤5)化合物(5)的合成
于-78℃下，向283mg(0.52mmol)化合物(1a-75)在2.6ml二氯甲烷中的溶液中加入1M三溴化硼在0.63ml(0.63mmol)二氯甲烷中的溶液，并于同样的温度下搅拌该混合物1小时。通过加入甲醇分解过量的试剂后，将该溶液倾入5％的碳酸氢钠水溶液中并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥并浓缩。残留物经从己烷-乙酸乙酯中结晶得到化合物(5)(204mg，收率87％)。(步骤6)化合物(Ⅰa-76)的合成
向184mg(0.41mmol)化合物(5)在2ml丙酮中的溶液中顺序加入169mg(1.23mmol)碳酸钾和0.12ml(1.02mmol)异戊二烯基溴，于室温下搅拌该混合物14小时。用乙酸乙酯稀释该溶液，用水和饱和盐水顺序洗涤，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯1∶1)，自己烷-乙酸乙酯结晶，得到化合物(Ⅰa-76)(170mg，收率80％)。(步骤7)化合物(Ⅰa-73)的合成
向149mg(0.29mmol)化合物(Ⅰa-76)在1.4ml四氢呋喃中的溶液中加入在冰冷却的0.6ml(2.89mmol)甲醇中的28％甲醇钠溶液，于室温下搅拌该混合物17小时。将该溶液倾入5％的氯化铵水溶液中并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙基7∶3)后，从乙醚-己烷中结晶获得的产物，得到化合物(Ⅰa-73)(88mg，收率84％)。
实施例2化合物(Ⅰb-15)、(Ⅰb-37)和(Ⅰb-49)的合成
Figure 9980434501611
(步骤1)化合物(Ⅰb-49)的合成
根据实施例1步骤1的方法，使200mg(0.74mmol)硼酸(6)与236mg(1.49mmol)2-氯代-5-硝基吡啶反应，得到化合物(Ⅰb-49)(232mg，收率90％)。(步骤2)化合物(Ⅰb-15)的合成
向257mg(0.74mmol)化合物(Ⅰb-49)在5ml甲苯中的溶液中加入5ml水、207mg(3.70mmol)铁粉和213mg(3.70mmol)氯化铵，将该混合物回流15小时。冷却后，用硅藻土滤除不溶性物质。用乙酸乙酯提取滤液，用饱和盐水洗涤该提取物，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯1∶3)后，从乙酸乙酯中结晶获得的产物，得到化合物(Ⅰb-15)(161mg，收率69％)。(步骤3)化合物(Ⅰb-37)的合成
向130mg(0.41mmol)化合物(Ⅰb-15)在4ml二氯甲烷中的溶液中加入冰冷却的0.05ml(0.61mmol)吡啶和86ml(0.49mmol)甲磺酸酐，搅拌该混合物1小时。用乙酸乙酯稀释该溶液，用水、5％的碳酸氢钠水溶液和饱和盐水顺序洗涤，干燥并浓缩。残留物经从乙酸乙酯中结晶得到化合物(Ⅰb-37)(124mg，收率77％)。
实施例3化合物(Ⅰb-11)、(Ⅰb-12)、(Ⅰb-16)、(Ⅰb-21)、(Ⅰb-46)和(Ⅰb-47)的合成
Figure 9980434501621
(步骤1)化合物(Ⅰb-46)的合成
于室温下，向867mg(1.36mmol)化合物(7)(WO98/04508，参考实施例4和6)在16ml 1,2-二甲氧基乙烷和5ml乙醇中的混合溶液中加入200mg(1.26mmol)2-氯代-5-硝基吡啶、44mg(0.04mmol)四(三苯膦)钯(0)和5mg 2M的碳酸钠水溶液，在氮气下回流该溶液3小时。冷却后，用水稀释该混合物并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥、浓缩，将获得的残留物溶于6ml四氢呋喃中。向该溶液中加入在2ml(2.02mmol)四氢呋喃中的冰冷却的1M四丁基氟化铵溶液，搅拌该混合物1.5小时。将该溶液倾入水中并用乙酸乙酯提取后，用饱和盐水洗涤该提取物，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯7∶3)，从己烷-乙酸乙酯中结晶获得化合物(Ⅰb-46)(472mg，收率79％)。(步骤2)化合物(Ⅰb-47)的合成
根据实施例1步骤4的方法，用0.40ml(2.89mmol)三乙胺和0.19ml(2.41mmol)甲磺酰氯处理458mg(0.97mmol)化合物(Ⅰb-46)在4.8ml四氢呋喃中的溶液，得到化合物(Ⅰb-47)(572mg，收率94％)。(步骤3)化合物(Ⅰb-12)的合成
根据实施例2步骤2的方法，用242mg(4.34mmol)铁粉和232mg(4.34mmol)氯化铵处理547mg(0.87mmol)化合物(Ⅰb-47)，得到化合物(Ⅰb-12)(461mg，收率89％)。(步骤4)化合物(Ⅰb-21)的合成
向110mg(0.18mmol)化合物(Ⅰb-12)在1.8ml二氯甲烷中的溶液中加入冰冷却的0.03ml(0.22mmol)的三氟乙酸酐，并于室温下搅拌该混合物2小时。用乙酸乙酯稀释该溶液，用水、5％的碳酸氢钠水溶液和饱和盐水顺序洗涤，干燥并浓缩。残留物经从乙醚-己烷中结晶得到化合物(Ⅰb-21)(122mg，收率96％)。(步骤5)化合物(Ⅰb-11)的合成
于室温下及氮气下，将122mg(0.18mmol)化合物(Ⅰb-21)、24mg20％氢氧化钯-炭在1.8ml甲醇和1.8ml1,4-二氧六环中的混合物搅拌15小时。用硅藻土滤除不溶性物质后，浓缩滤液得到110mg残留物。
向该残留物的3.5ml N,N-二甲基甲酰胺的溶液中顺序加入73mg(0.53mmol)碳酸钾和0.05ml(0.39mmol)异戊二烯基溴，搅拌该混合物4小时。用乙酸乙酯稀释该溶液，用水和饱和盐水顺序洗涤，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯7∶3)，从乙醚-己烷中结晶得到化合物(Ⅰb-11)(121mg，收率93％)。(步骤6)化合物(Ⅰb-16)的合成
根据实施例1步骤7的方法，从111mg(0.15mmol)化合物(Ⅰb-111)获得化合物(Ⅰb-16)(73mg，收率99％)。
实施例4化合物(Ⅰc-23)和(Ⅰc-24)的合成
Figure 9980434501641
(步骤1)化合物(9)的合成
根据实施例1步骤1的方法，使500mg(2.35mmol)化合物(8)与883mg(2.46mmol)硼酸(1)反应，得到化合物(9)(983mg，收率94％)。(步骤2)化合物(10)的合成
向983mg(2.20mmol)化合物(9)在10ml四氢呋喃的溶液中加入1M四丁基氟化铵在2.2ml(2.20mmol)四氢呋喃中的冰冷却溶液，于室温下搅拌该混合物1小时。将该溶液倾入水中并用乙酸乙酯提取后，用饱和盐水洗涤该提取物，干燥并浓缩。使残留物溶于10ml四氢呋喃中，然后将0.46ml(3.29mmol)三乙胺和0.20ml(2.64mmol)甲磺酰氯顺序加入冰冷却的该溶液中，于同样的温度下搅拌该混合物30分钟。用乙酸乙酯稀释该溶液，用水、5％的碳酸氢钠水溶液、饱和盐水顺序洗涤，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯7∶3)，得到化合物(10)(881mg，收率98％)。(步骤3)化合物(11)的合成
于室温下及氮气下，将120mg(0.29mmol)化合物(10)和11mg 10％钯-炭在2ml甲醇和2ml 1,4-二氧六环中的溶液搅拌2小时。用硅藻土滤除不溶性物质后，浓缩滤液。向该残留物的3ml甲醇溶液中加入冰冷却的11mg(0.29mmol)硼氢化钠，搅拌该混合物30分钟。将该溶液倾入水中并用乙酸乙酯提取。用饱和盐水洗涤该提取物，干燥并浓缩。向获得的粗产物在3ml丙酮中的溶液中顺序加入122mg(0.88mmol)碳酸钾和0.10ml(0.88mmol)异戊二烯基溴，于室温下搅拌该混合物2小时。用乙酸乙酯稀释该混合物，用水和饱和盐水顺序洗涤，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯7∶3)，得到化合物(11)(108mg，收率95％)。(步骤4)化合物(Ⅰc-24)的合成
向108mg(0.28mmol)化合物(11)在2ml乙腈中的溶液中加入87mg(0.33mmol)三苯膦和冰冷却的110mg(0.33mmol)四溴化碳，于室温下将该混合物搅拌1小时。向该混合物中加入152mg(1.38mmol)氢醌和114mg(0.83mmol)碳酸钾，于室温下将该混合物搅拌20小时。将该混合物倾入稀盐酸中并用乙酸乙酯提取。用5％的碳酸氢钠水溶液和饱和盐水洗涤提取物，干燥并浓缩。残留物经硅胶层析纯化(己烷-乙酸乙酯7∶3)，得到化合物(Ⅰc-24)(61mg，收率46％)。(步骤5)化合物(Ⅰc-23)的合成
根据实施例1步骤7的方法，由59mg(0.12mmol)化合物(Ⅰc-24)获得化合物(Ⅰc-23)(34mg，收率69％)。
实施例5化合物(Ⅰb-539)和(Ⅰb-540)的合成(步骤1)化合物(Ⅰb-539)的合成
使化合物(Ⅰb-250)(444mg,1mmol)溶于冰冷却的无水乙醚(40ml)中。在氮气及搅拌下，将氯代甲基氯代甲酸酯(194mg,1mmol)和三乙胺(210ml,1mmol)顺序加入该溶液中，在无冰冷却的情况下，搅拌该混合物4小时。滤除反应混合物中的沉淀，用水洗涤滤液，经无水硫酸钠干燥，减压浓缩，得到为油状物的540mg化合物(Ⅰb-539)。C31H34N2O3FCl的元素分析计算值：C,69.33；H,6.38；N,5.22；F,3.54；Cl,6.60。分析值：C,68.85；H,6.42；N,5.21,F,3.58；Cl,7.06。(步骤2)化合物(Ⅰb-540)的合成
于室温及减压下，将乙醇酸(glycol acid)(38mg,0.5mmol)、碳酸钾(35mg,0.25mmol)和N,N-二甲基甲酰胺(1ml)的混合物搅拌10分钟。加入化合物1(54mg,0.1mmol)在N,N-二甲基甲酰胺(0.5ml)中的溶液和溴化钾(12mg,0.1mmol)并在氩气下剧烈搅拌该混合物20小时。用乙醚(5ml)稀释该混合物，滤除不溶性物质。用水洗涤滤液，经无水硫酸钠干燥并减压浓缩。残留的粗产物经硅胶层析纯化(洗脱溶剂：己烷-乙酸乙酯2∶1)，得到为油状的27mg化合物(1b-540)。C33H37N2O6F的元素分析计算值：C,68.73；H,6.47；N,4.86；F,3.29。分析值：C,68.59；H,6.68；N,4.98,F,3.25。
实施例6化合物(Ⅰb-541)的合成
于室温及减压下，将琥珀酸(590mg,5mmol)、碳酸钾(345mg,2.5mmol)和N,N-二甲基甲酰胺(6ml)的混合物搅拌10分钟。顺序加入通过实施例5步骤1的方法获得的化合物(Ⅰb-539)(537mg,1mmol)在N,N-二甲基甲酰胺(5ml)中的溶液和碘化钠(70mg,0.5mmol)并在氩气下剧烈搅拌5天。将该混合物倾入5％乙酸的水溶液中并用乙醚-己烷(4∶1)提取。获得的混合物经无水硫酸钠干燥后，除去溶剂。残留的粗产物经硅胶层析纯化(洗脱溶剂：氯仿-甲醇(20∶1))，得到为油状的60mg化合物(lb-541)。C35H39N2O7F的元素分析计算值：C,67.95；H,6.35；N,4.53；F,3.07。分析值：C,68.25；H,5.96；N,4.64,F,3.13。LSIMS:m/z=618[M+H]+
实施例7其它化合物(Ⅰ)的合成
采用类似的方法，合成下列化合物(Ⅰ)。结构式和物理常数如下所示。表50-55表示用于表56或此后作为缩写A1、A2、…B1、B2、…C1、C2…的部分结构。
                                   表50
Figure 9980434501681
    R4  R5  R6  R7  X        Y
 A1     H  H  H  H  O        H
 A2     H  H  H  H  O    CH2-2-呋喃基
 A3     H  H  H  H  O     CH2C6H5
 A4     H  H  H  H  O    CH2C6H4-4-Me
 A5     H  H  H  H  O    CH2CH=CMe2
 A6     OH  H  H  H  O     CH2C6H5
 A7     OAc  H  H  H  O     CH2C6H5
 A8     OMs  H  H  H  O     CH2C6H5
 A9   OSO2CF3  H  H  H  O     CH2C6H5
 A10   OSO2Ph  H  H  H  O     CH2C6H5
 A11     OMe  H  H  H  O     CH2C6H5
 A12     OH  H  H  H  O    CH2C6H4-2-Me
 A13     OH  H  H  H  O    CH2C6H4-3-Me
 A14     OH  H  H  H  O    CH2C6H4-4-Me
 A15     OMs  H  H  H  O    CH2C6H4-2-Me
 A16     OMs  H  H  H  O    CH2C6H4-3-Me
 A17     OMs  H  H  H  O    CH2C6H4-4-Me
 A18     OH  H  H  H  O    CH2C6H4-2-OMe
 A19     OH  H  H  H  O    CH2C6H4-3-OMe
 A20     OH  H  H  H  O    CH2C6H4-4-OMe
 A21     OMs  H  H  H  O    CH2C6H4-2-OMe
 A22     OMs  H  H  H  O    CH2C6H4-3-OMe
 A23     OMs  H  H  H  O    CH2C6H4-4-OMe
 A24     OH  H  H  H  O       CH2-2-Py
 A25     OH  H  H  H  O       CH2-3-Py
 A26     OH  H  H  H  O       CH2-4-Py
 A27     OMs  H  H  H  O       CH2-2-Py
 A28     OMs  H  H  H  O       CH2-3-Py
 A29     OMs  H  H  H  O       CH2-4-Py
 A30     OH  H  H  H  O      CH2CH2C6H5
 A31     OMs  H  H  H  O      CH2CH2C6H5
 A32     OH  H  H  H  O      CH2CH=CMe2
 A33     OMs  H  H  H  O      CH2CH=CMe2
 A34     OH  H  H  H  O      CH2CH=CCl2
 A35     OMe  H  H  H  O      CH2CH=CMe2
                              表51
    R4  R5 R6  R7     X     Y  Y
 A36    OMe  H  H  H     O     CH2CH=CCl2
 A37     F  H  H  H     O     CH2CH=CMe2
 A38     F  H  H  H     O     CH2CH=CCl2
 A39    OH  H  H  H     O    CH2CH2CH=CMe2
 A40    OMs  H  H  H     O    CH2CH2CH=CMe2
 A41     H  H  H  H     NMe        Me
 A42     H  H  H  H     NH        H
 A43     H  H  H  H     NH        Me
 A44     H  H  H  H     NH       异丙基
 A45     H  H  H  H     NH     CH2CH=CH2
 A46     H  H  H  H     NH     CH2CH=CMe2
 A47     H  H  H  H     NH     CH2C≡CH
 A48     H  H  H  H     NH      环己基
 A49     H  H  H  H     NH     CH2-环己基
 A50     H  H  H  H     NH      CH2C6H5
A51 H H H H NH     CH2C6H4-4-COOMe
 A52     H  H  H  H     NH   CH2C6H4-4-COOH
 A53     H  H  H  H     NH      CH2-4-Pyr
 A54     H  H  H  H     NH     CH2-2-呋喃基
 A55     H  H  H  H     NH     CH2-3-呋喃基
 A56     H  H  H  H     NH     CH2-2-噻吩基
 A57     H  H  H  H     NH     CH2-3-噻吩基
 A58     H  H  H  H NCH2CH=CMe2       SO2NHMe
 A59     H  H  H  H     NMe       SO2NH2
 A60    OMe  H  H  H     NH     CH2CH=CMe2
 A61    OMe  H  H  H     NH       CH2C6H5
 A62     Me  H  H  H     NH     CH2CH=CMe2
 A63     Me  H  H  H     NH       CH2C6H5
 A64     H  F  H  H     NH          H
 A65     H  F  H  H     NH        异丙基
 A66     H  F  H  H     NH        异丁基
 A67     H  F  H  H     NH      CH2CH=CMe2
 A68     H  F  H  H     NH        环戊基
 A69     H  F  H  H     NH        环己基
 A70     H  F  H  H     NH      CH2环己基
 A71     H  F  H  H     NH    CH2C6H4-4-Et
 A72     H  F  H  H     NH   CH2C6H4-4-异丙基
 A73     H  F  H  H     NH   CH2C6H4-4-COOH
 A74     H  F  H  H     NH     CH2C6H4-4-COOMe
 A75     H  F  H  H    N-异丙基       SO2NH2
 A76     H  F  H  H    N-异丙基       SO2NHMe
 A77     H  F  H  H   NCH2CH=CMe2       SO2NHMe
                                 表52
                                表53
                            表54
Figure 9980434501721
    R8     R8     R10    R11
 B1     OMe     H     H    OMe
 B2     OMe     H     OH    OMe
 B3     OMe     H    OMs    OMe
 B4     Me     H     H     Me
 B5     Me     H     OH     Me
 B6     Me     H    OMs     Me
 B7     Me     Me     Me     Me
 B8     Me     Me    OMe     Me
 B9     Me     Me     OH     Me
 B10     Me     Me     Me    OMe
 B11     Me     Me     Me     OH
 B12     OMe     Me     Me    OMe
 B13     Me     H     Me     Me
 B14     Me     Me     H     Me
 B15     Me     H     F     Me
 B16     Me     F     H     Me
 B17     OMe     H     H     Me
 B18     Me     H     H    OMe
 B19     Cl     H     H     Cl
 B20     OEt     H     H    OEt
 B21  O异丙基     H     H  O异丙基
B22  O环丙基     H     H  O环丙基
B23     OMe     Me     Me  COOMe
 B24     Me     Me     Me  COOMe
 B25     SMe     H     H    SMe
 B26     SEt     H     H    SEt
 B27    COOMe     Me     Me    OMe
 B28     Me     Me     Me     Cl
 B29     Me    OMe     H     Me
 B30    COOMe     Me     Me     Me
 B31     Cl     Me     Me     Me
 B32     H     Me     Me     Cl
 B33     Me     H     Cl     Me
 B34     H     Me     Cl     H
 B35     Me     H     H     C1
B36     Me     Me     H     H
 B37     H     Me     H     Me
 B38     Me     H     Me     H
 B39    OMe    OMe     H     H
 B40     H    OMe     H    OMe
 B41    OMe     H    OMe     H
 B42     H     Me     H    OMe
 B43    OMe     H     Me     H
                           表55
Figure 9980434501731
R12     R13  R14 R15    -X1-Y1
 C1  H     H  H  H     H
 C2  H     H  H  H     OH
 C3  H     H  H  H     OMs
 C4  H     H  H  H     OMe
 C5  H     H  H  H     NH2
 C6  H     H  H  H     NMe2
 C7  H     H  H  H     SMe
 C8  H     H  H  H     Ms
 C9  H     H  H  H      F
 C10  H     CF3  H  H      H
 C11  H     NO2  H  H      H
 C12  H     NH2  H  H      H
 C13  H     NHAc  H  H      H
 C14  H     NHMs  H  H      H
 C15  H  N(Ms)CH2CH=CMe2  H  H      H
 C16  H     OH  H  H   OCH2C6H5
 C17  H     OMs  H  H   OCH2C6H5
 C18  H     OH  H  H  OCH2CH=CMe2
 C19  H     OMe  H  H  OCH2CH=CMe2
 C20  H     OMs  H  H  OCH2CH=CMe2
 C21 NO2     H  H  H      H
 C22 NH2     H  H  H      H
 C23 NHAc     H  H  H      H
 C24 NHMs     H  H  H      H
 C25  Cl     H  H  H     NO2
 C26  Cl     H  H  H     NH2
 C27  Cl     H  H  H     NHMs
 C28  Cl     H  H  H   NHCOCF3
 C29  Cl     H  H  H  NHCH2CH=CMe2
 C30  H     H  H  H  NHCH2CH=CMe2
                              表56
Figure 9980434501742
                             表57
                                 表58
Figure 9980434501761
                               表59
                                 表60
                                   表61
                                  表62
Figure 9980434501801
                                   表63
Figure 9980434501811
                                    表64
                                  表65
Figure 9980434501831
                                  表66
Figure 9980434501841
                               表67
                                    表68
Figure 9980434501861
                                 表69
Figure 9980434501871
                                 表70
                                表71
                                   表72
Figure 9980434501901
                                  表73
Figure 9980434501911
                              表74
                                表75
Figure 9980434501931
                             表76
Figure 9980434501941
                                  表77
                                  表78
Figure 9980434501961
                                    表79
Figure 9980434501971
                                   表80
                                表81
                                   表82
    No.     V2     C     B     A
    Ⅰc-1     O     C2     B4     A32
    Ⅰc-2     O     C2     B4     A35
    Ⅰc-3     O     C3     B4     A6
    Ⅰc-4     O     C3     B4     A8
    Ⅰc-5     O     C3     B4     A11
    Ⅰc-6     O     C3     B4     A33
    Ⅰc-7     O     C3     B4     A35
    Ⅰc-8     O     C5     B4     A11
    Ⅰc-9     O     C5     B4     A35
    Ⅰc-10     O     C6     B1     A35
    Ⅰc-11     O     C6     B1     A37
    Ⅰc-12     O     C6     B4     A11
    Ⅰc-13     O     C6     B4     A32
    Ⅰc-14     O     C6     B4     A35
    Ⅰc-15     O     C19     B4     A35
    Ⅰc-16     O     C25     B4     A41
    Ⅰc-17     O     C26     B4     A41
    Ⅰc-18     O     C27     B4     A41
    Ⅰc-19     O     C28     B4     A41
    Ⅰc-20     O     C29     B4     A41
    Ⅰc-21     NH     C2     B4     A32
    Ⅰc-22     NH     C2     B4     A35
    Ⅰc-23     OCH2     C2     B4     A32
    Ⅰc-24     OCH2     C2     B4     A33
                                表83
    No.      V2     C     B      A
    Ⅰc-25     OCH2     C2     B4     A35
    Ⅰc-26     OCH2     C6     B4     A35
    Ⅰc-27     OCH2     C19     B4     A35
    Ⅰc-28     CH2O     C2     B1     A32
    Ⅰc-29     CH2O     C2     B1     A35
    Ⅰc-30     CH2O     C2     B4     A35
    Ⅰc-31     CH2O     C3     B1     A33
    Ⅰc-32     CH2O     C3     B4     A33
    Ⅰc-33    NHCH2     C2     B4     A35
    Ⅰc-34    NHCH2     C6     B4     A35
    Ⅰc-35    CH=CH     C2     B4     A32
    Ⅰc-36    CH=CH     C2     B4     A33
    Ⅰc-37    CH=CH     C2     B4     A35
    Ⅰc-38    CH=CH     C3     B4     A33
    Ⅰc-39    CH=CH     C6     B4     A32
    Ⅰc-40    CH=CH     C6     B4     A35
    Ⅰc-41    CH=CH     C19     B4     A35
    Ⅰc-42     C=C     C2     B4     A32
    Ⅰc-43     C=C     C2     B4     A35
    Ⅰc-44     C=C     C3     B4     A35
    Ⅰc-45     C=C     C19     B4     A35
    Ⅰc-46     CO     C2     B4     A32
    Ⅰc-47     CO     C2     B4     A35
    Ⅰc-48   CH(OH)     C2     B4     A32
    Ⅰc-49   CH(OH)     C2     B4     A35
                       表84
Figure 9980434502011
Figure 9980434502012
                           表85
                               表86
Figure 9980434502031
Figure 9980434502032
                             表87
Figure 9980434502041
Figure 9980434502042
                            表88
    No.                               mp,1H-NMR
   Ⅰa-2 195-197℃,1H-NMR(CDCl3-DMSO-d6)δ1.77(3H,s),1.82(3H,s),4.63(2H,J=6.8),5.52(1H,brt,J=6.8),6.25(1H,s),6.93-6.98(3H,m),7.10(1H,dd,J=2.2,8.3),7.20(1H,d,J=2.2),7.69(1H,d,J=8.1),7.85(1H,dd,J=2.0,8.1),7.89(2H,d,J=8.8),8.53(1H,brs),8.82(1H,d,J=2.0)
   Ⅰa-4 181-182℃,1H-NMR(CDCl3)δ3.18(3H,s),5.19(2H,s),5,78(1H,s),7.04(1H,d,J=8.3),7,12(1H,dd,J=2.2,8.3),7.25(1H,d,J=2.2),7.38-7.45(7H,m),7.76(1H,brd,J=8.3),7.92(1H,dd,J=2.4,8.3),8.88(1H,brd,J=2.4)
   Ⅰa-5 171-172℃,1H-NMR(CDCl3)δ3.40(3H,s),3.43(3H,s),5.29(2H,s),7.36-7.53(8H,m),7.78-7.81(2H,m),8.09(1H,d,J=8.3),8.21(1H,dd,J=2.2,8.3),8.25(2H,d,J=8.8),9.02(1H,brs)
   Ⅰa-6 165-166℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.18(3H,s),3.25(3H,s),4.65(2H,d,J=6.8),5.50(1H,brt,J=6.8),7.13(1H,d,J=8.5),7.42(2H,d,J=8.8),7.53(1H,dd,J=2.2,8.5),7.58(1H,d,J=2.2),7.77(1H,dd,J=0.7,8.3),7.92(1H,dd,J=2.2,8.3),8.10(2H,d,J=8.8),8.88(1H,dd,J=0.7,2.2)
   Ⅰa-8 176-177℃,1H-NMR(CDCl3)δ3.87(3H,s),5.18(2H,s),5.77(1H,s),7.01(2H,d,J=9.0),7.02(1H,d,J=8.6),7.11(1H,dd,J=2.2,8.6),7.24(1H,d,J=2.2),7.40-7.45(5H,m),7.71(1H,dd,J=1.0,8.3),7.86(1H,dd,J=2.4,8.3),7.99(2H,d,J=9.0),8.84(1H,dd,J=1.0,2.4)
   Ⅰa-9 187-188℃,1H-NMR(CDCl3)δ3.13(3H,s),3.88(3H,s),5.19(2H,s),7.02(2H,d,J=8.8),7.17(1H,d,J=8.6),7.37-7.49(5H,m),7.51(1H,dd,J=2.2,8.6),7.59(1H,d,J=2.2),7.73(1H,brd,J=8.3),7.86(1H,dd,J=2.4,8.3),8.00(2H,d,J=8.8),8.83(1H,brd,J=2.4)
   Ⅰa-10 141-142℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.88(3H,s),4.63(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.79(1H,5),6.97(1H,d,J=8.3),7.02(2H,d,J=9.0),7.11(1H,dd,J=2.2,8.3),7.21(1H,d,J=2.2),7.71(1H,dd,J=0.7,8.3),7.86(1H,dd,J=2.4,8.3),7.99(2H,d,J=9.0),8.85(H,dd,J=0.7,2.4)
   Ⅰa-11 161-162℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.24(3H,s),3.88(3H,s),4.65(2H,d,J=6.8),5.50(1H,brt,J=6.8),7.02(2H,d,J=9.0),7.11(1H,d,J=8.5),7.52(1H,dd,J=2.4,8.5),7.57(1H,d,J=2.4),7.73(1H,dd,J=0.7,8.3),7.86(1H,dd,J=2.4,8.3),8.00(2H,d,J=9.0),8.83(1H,dd,J=0.7,2.4)
   Ⅰa-12 233-236℃,1H-NMR(CDCl3)δ3.13(3H,s),3.14(3H,s),5.20(2H,s),5.21(2H,s),7.17(2H,dd,J=1.7,8.3),7.36-7.54(11H,m),7.59(1H,d,J=2.4),7.73(1H,d,J=8.3),7.78(1H,dd,J=2.4,8.3),7.98-8.02(2H,m),8.84(1H,d,J=2.5)
   Ⅰa-13 150-151℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(6H,s),4.63(4H,d,J=6.8),5.52(2H,brt,J=6.8),5.73(1H,s),5.78(1H,s),6.97(2H,d,J=8.3),7.10(1H,dd,J=2.2,8.3),7.21(1H,d,J=2.2),7.57(1H,dd,J=2.2,8.3),7.60(1H,d,J=2.2),7.69(1H,brd,J=8.3),7 85(1H,dd,J=2.4,8.3),8.84(1H,brd,J=2.4)
   Ⅰa-15 172-173℃,1H-NMR(CDCl3)δ5.11(1H,s),5.17(2H,s),5.75(1H,s),6.93(2H,d,J=8.5),6.95-7.03(2H,m),7.11(1H,d,J=2.0),7.38-7.45(5H,m),7.62(1H,d,J=8.1),7.67(1H,d,J=8.1),7.96(2H,d,J=8.5)
                                 表89
    Ⅰa-16 159-161℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),4.63(2H,d,J=6.8),5.02(1H,s),5.52(1h,brt,J=6.8),5.75(1H,s),6.92(2H,d,J=8.5),6.94(1H,d,J=8.3),6.97(1H,dd,J=2.2,8.3),7.08(1H,d,J=2.2),7.62(1H,d,J=8.1),7.66(1H,d,J=8.1),7.95(2H,d,J=8.5)
    Ⅰa-17 134-134.5℃,1H-NMR(CDCl3)δ3.13(3H,s),3.18(3H,s),5.20(2H,s),7.16(1H,d,J=8.5),7.37-7.50(9H,m),7.71和7.74(各为1H,ABq,J=8.1),8.10(2H,d,J=8.8)
    Ⅰa-18 99-100℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.19(3H,s),3.24(3H,s),4.66(2H,d,J=6.8),5.51(1h,brt,J=6.8),7.10(1H,d,J=8.5),7.38-7.48(4H,m),7.71和7.74(各为1H,ABq,J=8.1),8.10(2H,d,J=8.8)
    Ⅰa-21 215-216℃,1H-NMR(CDCl3-DMSO-d6)δ1.77(3H,s),1.82(3H,s),2.35(3H,s),4.63(2H,d,J=6.8),5.54(1H,brt,J=6.8),6.51(1H,s),6.79(1H,dd,J=2.2,8.1),6.93-6.96(4H,m),7.52(1H,s),7.87(2H,d,J=8.8),8.43(1H,s),8.79(1H,s)
    Ⅰa-22 203-204℃,1H-NMR(CDCl3)δ1.76(3H,s),1.80(3H,s),2.37(3H,s),3.89(3H,s),4.64(2H,d,J=6.8),5.56(1H,brt,J=6.8),6.20(1H,brs),6.86-6.89(2H,m),6.89(2H,d,J=8.8),6.97(1H,d,J=8.5),7.55(1H,s),7.88(2H,d,J=8.8),8.48(1H,s)
    Ⅰa-23 140-141℃,1H-NMR(CDCl3)δ2.39(3H,s),3.17(3H,s),5.18(2H,s),5.78(1H,s),6.83(1H,dd,J=2.2,8.3),6.98(1H,d,J=2.2),7.03(1H,d,J=8.3),7.40(2H,d,J=8.8),7.41-7.47(5H,m),7.59(1H,s),8.07(2H,d,J=8.8),8.50(1H,s)
    Ⅰa-24 156-157℃,1H-NMR(CDCl3)δ2.39(3H,s),3.13(3H,s),3.18(3H,s),5.20(2H,s),7.18(1H,d,J=8.5),7.26(1H,dd,J=2.0,8.5),7.36-7.49(8H,m),7.61(1H,s),8.07(2H,d,J=90.),8.50(1H,s)
    Ⅰa-25 111-112℃,1H-NMR(CDCl3)δ1.78(3H,s),1.83(3H,s),2.39(3H,s),3.18(3H,s),3.24(3H,s),4.65(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.11(1H,d,J=8.5),7.26(1H,dd,J=2.2,8.5),7.34(1H,d,J=2.2),7.40(2H,d,J=8.8),7.60(1H,s),8.07(2H,d,J=8.8),8.50(1H,s)
    Ⅰa-26 124-127℃,1H-NMR(CDCl3)δ1.77(3H,s),1.80(3H,s),2.39(3H,s),3.18(3H,s),3.90(3H,s),4.65(2H,d,J=6.8),5.57(1H,brt,J=6.8),6.87-6.912H,m),6.98(1H,d,J=8.3),7.40(2H,d,J=8.8),7.60(1H,s),8.08(2H,d,J=8.8),8.53(1H,s)
    Ⅰa-27 213-214℃,1H-NMR(CDCl3)δ2.58(3H,s),5.21(2H,s),5.87(1H,s),7.06-7.18(5H,m),7.42-7.49(7H,m),8.29(1H,brs),8 86(1H,brs),9.011H,brs)
    Ⅰa-28 198-199℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.42(3H,s),4.63(2H,d,J=6.7),5.51(1H,t,J=6.7),5.68(1H,s),5.77(1H,s),6.87(2H,d,J=7.8),6.96(1H,d,J=8.5),7.10(1H,dd,J=8.5,2.4),7.21(1H,d,J=2.4),7.44(2H,d,J=7.8)7.71(1H,d,J=2.4),8.68(1H,d,J=2.4),
    Ⅰa-31 198-199℃,1H-NMR(CDCl3)δ2.53(3H,s),3.14(3H,s),3.21(3H,s),5.21(2H,s),7.22(1H,d,J=8.5),7.39-7.49(7H,m),7.55-7.62(2H,m),7.73(2H,d,J=9.2),8.05(1H,brs),8.84(1H,brs)
    Ⅰa-32 142-144℃,1H-NMR(CDCl3)δ1.78(3H,s),1.82(3H,s),2.43(3H,s),3.17(3H,s),3.24(3H,s),4.65(2H,d,J=6.7),5.50(1H,brt,J=6.7),7.12(1H,d,J=8.5),7.40(2H,dd,J=6.7,1.8),7.52(1H,dd,J=8.6,2.4),7.57(1H,s)7.64(2H,d,J=8.5),7.74(1H,s)8.70(1H,d,J=2.5)
                                  表90
    Ⅰa-35 152-154℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.59(3H,s),4.12(2H,d,J=7.3),5.53(1H,t,J=7.3),5.77(1H,brs),6.79-6.95(5H,m),7.49(1H,d,J=8.0),7.55(1H,d,J=8.0),7.88(2H,d,J=8.5)
    Ⅰa-38 109-112℃,1H-NMR(CDCl3)δ2.60(3H,s),3.12(3H,s),3.16(3H,s),5.19(2H,s),7.15(1H,d,J=8.5),7.27(1H,dd,J=7.8,1.8),7.35-7.50(8H,m),7.59(2H,s),8.09(2H,d,J=9.2)
    Ⅰa-39 oil,1.78(3H,s),1H-NMR(CDCl3)δ1.82(3H,s),2.60(3H,s),3.17(3H,s),3.24(3H,s),4.65(2H,d,J=6.7),5.51(1H,brt,J=6.7),7.09(1H,d,J=8.6),7.24-7.27(1H,m),7.34-7.35(2H,m),7.40(1H,d,J=8.6)7.59(2H,s),8.09(2H,d,J=9.2)
    Ⅰa-42 175-176℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.32(3H,s),2.54(3H,s),4.63(2H,d,J=6.8),5.52(1H,brs),5.53(1H,t,J=6.8),5.75(1H,brs),6.80-6.84(3H,m),6.93(1H,d,J=7.8),6.95(1H,d,J=1.8),7.38-7.41(3H,m)
    Ⅰa-43 177-178℃,1H-NMR(CDCl3)δ1.77(3H,s),1.79(3H,s),2.32(3H,s),2.56(3H,s),3.90(3H,s),4.64(2H,d,J=6.8),5.56(1H,t,J=6.8),6.75(2H,d,J=8.5),6.87-6.97(3H,m),7.33(2H,d,J=8.5),7.43(1H,s)
    Ⅰa-45 79-81℃,1H-NMR(CDCl3)δ2.33(3H,s),2.53(3H,s),3.16(3H,s),5.18(2H,s),5.75(1H,s),6.83(1H,dd,J=7.8,1.8),6.98(1H,d,J=1.8),7.00(1H,d,J=8.5),7.37-7.55(8H,m),7.63(2H,d,J=8.5)
    Ⅰa-46 163-164℃,1H-NMR(CDCl3)δ2.34(3H,s),2.54(3H,s),3.13(3H,s),3.17(3H,s),5.19(2H,s),7.15(1H,d,J=8.5),7.27(1H,dd,J=8.5,2.5),7.35-7.50(9H,m),7.62(2H,d,J=8.5)
    Ⅰa-47 oil,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.34(3H,s),2.54(3H,s),3.17(3H,s),3.23(3H,s),4.66(2H,d,J=7.3),5.51(1H,brt,J=7.3),7.08(1H,d,J=8.6),7.26(1H,dd,J=8.6,2.4),7.35(1H,d,J=2.4),7.39(2H,d,J=8.6),7.43(1H,s),7.64(2H,d,J=8.6)
    Ⅰa-48 149-150℃,1H-NMR(CDCl3)δ1.77(3H,s),1.80(3H,s),2.35(3H,s),2.54(3H,s),3.17(3H,s),3.90(3H,s),4.64(2H,d,J=6.8),5.57(1H,t,J=6.8),6.87(1H,s),6.88-6.98(2H,m),7.39(2H,d,J=8.5),7.44(1H,s),7.63(2H,d,J=8.5)
    Ⅰa-65 237-239℃,1H-NMR(CDCl3-CD3OD)δ3.16(3H,s),5.21(2H,s),6.96(2H,d,J=8.6),7.20(1H,d,J=9.3),7.38-7.51(5H,m),7.72(1H,brd,J=8.3),7.90-7.95(3H,m),8.80(1H,brd,J=2.4)
    Ⅰa-66 152-153℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),5.59(1H,brs),5.75(1H,s),6.95(2H,d,J=8.6),6.97(1H,d,J=8.3),7.50(2H,d,J=8.6),7.56(1H,dd,J=2.2,8.3),7.59(1H,d,J=2.2),7.69(1H,dd,J=0.7,8.3),7.86(1H,2.4,8.3),8.83(1H,dd,J=0.7,2.4)
    Ⅰa-68 167-168℃,1H-NMR(CDCl3)δ3.13(3H,s),3.20(3H,s),5.21(2H,s),7.18(1H,d,J=8.3),7.38-7.48(7H,m),7.67(2H,d,J=8.8),7.76(1H,brd,J=3.3),7.91(1H,dd,J=2.4,8.3),7.99-8.03(2H,m),8.85(1H,brd,J=2.4)
    Ⅰa-69 151-152.5℃,1H-NMR(CDC13)δ1.77(3H,s),1.81(3H,s),3.20(3H,s),3.24(3H,s),4.66(2H,d,J=6.8),5.50(1H,brt,J=6.8),7.12(1H,d,J=9.3),7.42(2H,d,J=8.5),7.67(2H,d,J=8.5),7.76(1H,brd,J=8.3),7.90(1H,dd,J=2.4,8.3),8.00-8.03(2H,m),8.85(1H,brd,J=2.4)
    Ⅰa-71 220-221℃1H-NMR(CDCl3)δ2.57(3H,s),3.51(2H,brs),5.18(2H,s),7.14(1H,d,J=7.3),7.15-7.62(11H,m),8.11(1H,d,J=1.8),8.78(1H,d,J=1.8)
                                表91
    Ⅰa-73 180-181℃,1H-NMR(CDCl3)δ1.74(3H,s),1.79(3H,s),2.42(3H,s),4.61(2H,d,J=6.8),5.50(1H,t,J=6.8),6.84-6.96(5H,m),7.05(1H,dd,J=7.8,1.8),7.14(1H,d,J=1.8),7.44(2H,d,J=9.2),7.71(1H,f,J=1.8)8.65(1H,d,J=1.8),
    Ⅰa-75 164-165℃,1H-NMR(CDCl3)δ2.53(3H,s),3.13(3H,s),3.21(3H,s),5.19(2H,s),7.16(1H,d,J=7.3),7.32-7.50(7H,m),7.61(2H,dd,J=8.5,2.4),7.70(2H,d,J=7.3),7.79(1H,d,J=1.8)8.76(1H,d,J=1.8)
    Ⅰa-76 151-152℃1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.48(3H,s),3.20(3H,s),3.21(3H,s),4.65(2H,d,J=6.8),5.50(1H,t,J=6.8),7.11(1H,d,J=7.9),7.41(2H,d,J=9.2),7.55(1H,dd,J=7.8,1.8),7.58(1H,s),7.66(2H,d,J=7.9),7.74(1H,d,J=1.8)8.71(1H,d,J=1.8),
    Ⅰa-79 189-191℃,1H-NMR(CDCl3)δ2.34(3H,s),5.18(2H,s),5.29(1H,brs),5.71(1H,s),6.83(1H,dd,J=2.2,8.3),6.92(2H,d,J=8.6),7.03(1H,d,J=8.3),7.23(2H,d,J=8.6),7.37-7.47(5H,m),7.54(1H,s),7.55(1H,dd,J=2.2,8.3),7.60(2H,d,J=2.2),8.45(1H,s)
    Ⅰa-80 165-166℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.35(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),5.75(1H,s),6.19(1H,brs),6.92(2H,d,J=8.8),6.96(1H,d,J=8.8),7.21(2H,d,J=8.8),7.52-7.57(3H,m),8.44(1H,s)
    Ⅰa-82 18.9-190℃,1H-NMR(CDCl3)δ2.35(3H,s),3.13(3H,s),3.22(3H,s),5.20(2H,s),7.18(1H,d,J=9.0),7.36-7.49(9H,m),7.58(1H,s),7.99-8.02(2H,m),8.46(1H,s)
    Ⅰa-83 169-170℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.35(3H,s),3.22(3H,s),3.24(3H,s),4.66(2H,d,J=6.8),5.50(1H,brt,J=6.8),7.11(1H,d,J=8.6),7.40(4H,s),7.58(1H,s),7.96(1H,d,J=2.2),8.00(1H,dd,J=2.2,8.6),8.45(1H,s)
    Ⅰa-85 143-146℃,1H-NMR(CDCl3)δ2.53(3H,s),5.03(1H,brs),5.18(2H,s),5.72(1H,s),6.92(2H,dd,J=7.8,1.8),7.02(1H,d,J=6.8),7.23(2H,dd,J=7.3,1.8),7.33-7.48(5H,m),7.49-7.60(3H,m),7.67(1H,d,J=1.8)
    Ⅰa-87 168-169℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.56(3H,s),4.63(2H,d,J=6.8),4.84(1H,s),5.51(1H,t,J=6.8),5.70(1H,s),6.91(2H,d,J=8.5),6.95(1H,d,J=8.5),7.22(2H,s),7.51(2H,s),7.55(1H,dd,J=8,5,2.4),7.62(1H,d,J=2.4)
    Ⅰa-89 174-175℃,1H-NMR(CDCl3)δ2.56(3H,s),3.13(3H,s),3.21(3H,s),5.20(2H,s),7.15(1H,d,J=8.5),7.29-7.48(9H,m),7.56(2H,s),7.99(1H,dd,J=8.5,2.4),8.03(1H,d,J=2.4)
    Ⅰa-90 141-142℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.56(3H,s),3.21(3H,s),3.24(3H,s),4.65(2H,d,J=6.8),5.50(1H,t,J=6.8),7.10(1H,d,J=8.6),7.36-7.43(4H,m),7.55(2H,d,J=1.2),7.98(1H,dd,J=8.6,2.4),8.01(1H,d,J=1.2)
    Ⅰa-93 118-121℃,1H-NMR(CDCl3)δ2.36(3H,s),2.51(3H,s),3.10(3H,s),5.10(1H,brs),5.18(2H,s),6.90(2H,d,J=8.6),7.14(1H,d,J=8.6),7.21-7.48(8H,m),7.52(1H,dd,J=8.6,1.8).7.58(1H,d,J=1.8)
    Ⅰa-94 168-169℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.33(3H,s),2.51(3H,s),4.61(2H,d,J=6.8),5.32(1H,brs),5.51(1H,t,J=6.8),5.73(1H,s),6.87-6.95(3H,m),7.04(1H,dd,J=8.5,1.8),7.14(1H,d,J=1.8),7.21-7.24(2H,m),7.37(1H,s)
    Ⅰa-96 140-141℃,1H-NMR(CDCl3)δ2.38(3H,s),2.50(3H,s),3.11(3H,s),3.21(3H,s),5.19(2H,s),7.16(1H,d,J=8.5),7.33-7.51(10H,m),7.55(1H,dd,J=7.8,1.8),7.62(1H,d,J=1.8)
                               表92
    Ⅰa-97 106-107℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.38(3H,s),2.51(3H,s),3.20(3H,s),3.21(3H,s),4.64(2H,d,J=6.8),5.49(1H,t,J=6.8),7.10(1H,d,J=8.0),7.35-7.44(5H,m),7.51-7.65(2H,m)
    Ⅰa-125 121-122℃,1H-NMR(CDCl3)δ2.38(3H,s),3.90(3H,s),4.03(3H,s),5.21(2H,s),6.77(1H,dd,J=2.0,8.3),6.82(1H,d,J=2.0),6.97(1H,d,J=8.3),7.32-7.49(8H,m),8.46-8.49(2H,m)
    Ⅰa-127 110-111℃,1H-NMR(CDCl3)δ2.39(3H,s),4.03(3H,s),5.11(2H,s),7.06(2H,d,J=8.5),7.22(2H,d,J=8.5),7.34-7.51(8H,m),8.44-8.50(2H,m)
    Ⅰa-128 115-116℃,1H-NMR(CDCl3)δ2.38(3H,s),4.03(3H,s),5.07(2H,s),7.06(2H,d,J=9.2),7.21(4H,d,J=9.2),7.36(2H,d,J=8.5),7.45-7.51(3H,m),8.46-8.50(2H,m)
    Ⅰa-129 129-130℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.39(3H,s),4.03(3H,s),4.56(2H,d,J=6.7),5.55(1H,brt,J=6.7),7.00(2H,d,J=8.5),7.21(2H,d,J=8.5),7.46-7.51(3H,m),8.46-8.50(2H,m)
    Ⅰa-131 121-122℃,1H-NMR(CDCl3)δ2.39(3H,s),4.03(3H,s),5.16(2H,s),5.75(1h,s),6.76(1H,dd,J=2.2,8.3),6.90(1H,d,J=2.2),7.01(1H,d,J=8.1),7.38-7.5(8H,m),8.46-8.50(2H,m)
    Ⅰa-132 142-143℃,1H-NMR(CDCl3)δ2.29(3H,s),2.41(3H,s),4.02(3H,s),5.14(2H,s),7.02(1H,d,J=1.2),7.05-7.11(2H,m),7.33-7.49(8H,m),8.45-8.50(2H,m)
    Ⅰa-133 161.5-162.5℃,1H-NMR(CDCl3)δ2.42(3H,s),3.11(3H,s),4.03(3H,s),5.18(2H,s),7.14(1H,d,J=8.6),7.21(1H,dd,J=2.0,8.6),7.31(1H,d,J=2.0),7.37-7.50(8H,m),8.46-8.49(2H,m)
    Ⅰa-134 142-143℃,1H-NMR(CDCl3)δ2.39(3H,s),4.03(3H,s),5.23(2H,s),7.15(1H,d,J=8.5),7.17-7.25(2H,m),7.33-7.51(8H,m),8.45-8.50(2H,m)
    Ⅰa-135 132-133℃,1H-NMR(CDCl3)δ2.37(3H,s),4.03(3H,s),4.94(2H,s),6.98(1H,d,J=8.6),7.15(1H,dd,J=1.8,8.6),7.17(1H,d,J=1.8),7.33-7.60(11H,m),7.87(2H,d,J=7.3),8.45-8.59(2H,m)
    Ⅰa-136 127-128℃,1H-NMR(CDCl3)δ2.40(3H,s),2.42(3H,s),4.04(3H,s),5.14(2H,s),5.70(1H,s),6.79(1H,dd,J=1.8,7.9),6.90(1H,d,J=1.8),7.05(1H,d,J=7.9),7.22-7.36(3H,m),7.40(1H,d,J=6.7),7.43-7.55(3H,m),8.44-8.50(2H,m)
    Ⅰa-137 87-89℃,1H-NMR(CDCl3)δ2.39(3H,s),2.41(3H,s),4.03(3H,s),5.12(2H,s),5.73(1H,s),6.76(1H,dd,J=1.8,7.9),6.90(1H,d,J=1.8),7.011H,d,J=7.9),7.18-7.36(4H,m),7.43-7.53(3H,m),8.46-8.52(2H,m)
    Ⅰa-138 114-115℃,1H-NMR(CDCl3)δ2.39(6H,s),4.02(3H,s),5.10(2H,s),5.741H,s),6.75(1H,dd,J=2.0,8.3),6.89(1H,d,J=2.0),7.01(1H,d,J=8.3),7.24(2H,d,J=8.6),7.36(2H,d,J=8.6),7.45-7.50(3H,m),8.46-8.50(2H,m)
    Ⅰa-139 92-193℃,1H-NMR(CDCl3)δ2.42(3H,s),2.43(3H,s),3.06(3H,s),4.04(3H,s),5.16(2H,s),7.15-7.33(6H,m),7.41-7.50(4H,m),8.46-8.51(2H,m)
    Ⅰa-140 151-152℃,1H-NMR(CDCl3)δ2.39(3H,s),2.42(3H,s),3.12(3H,s),4.03(3H,s),5.14(2H,s),7.14(1H,d,J=8.5),7.18-7.31(6H,m),7.46-7.50(3H,m),8.45-8.50(2H,m)
    Ⅰa-141 188-189℃,1H-NMR(CDCl3)δ2.39(3H,s),2.41(3H,s),3.11(3H,s),4.03(3H,s),5.13(2H,s),7.14(1H,d,J=8.6),7.20(1H,dd,J=2.2,8.6),7.22(2H,d,J=8.0),7.30(1H,d,J=2.2),7.36(2H,d,J=8.0),7.47-7.50(3H,m),8.46-8.49(2H,m)
                               表93
  Ⅰa-142 166-167℃,1H-NMR(CDCl3)δ2.39(3H,s),3.91(3H,s),4.03(3H,s),5.15(2H,s),6.18(1H,s),6.75(1H,dd,J=1.8,7.9),6.89(1H,d,J=2.4),6.97(1H,d,J=7.9),7.03(1H,d,J=7.9),7.34-7.49(5H,m),8.46-8.50(2H,m)
  Ⅰa-143 166-167℃,1H-NMR(CDCl3)δ2.39(3H,s),3.84(3H,s),4.03(3H,s),5.13(2H,s),5.74(1H,s),6.75(1H,dd,J=1.8,8.5),6.89(1H,d,J=1.8),6.90-7.05(4H,m),7.34(1H,d,J=7.9),7.44-7.50(3H,m),8.45-8.50(2H,m)
  Ⅰa-144 125-126℃,1H-NMR(CDCl3)δ2.39(3H,s),3.85(3H,s),4.03(3H,s),5.08(2H,s),5.70(1H,s),6.76(1H,dd,J=1.8,7.9),6.89(1H,d,J=8.5),6.96(2H,d,J=8.5),7.02(1H,d,J=7.9),7.38(2H,d,J=8.5),7.44-7.50(3H,m),8.45-8.50(2H,m)
  Ⅰa-145 193-195℃,1H-NMR(CDCl3)δ2.42(3H,s),3.13(3H,s),3.87(3H,s),4.03(3H,s),5.21(2H,s),6.94(1H,d,J=7.9),6.98-7.04(1H,m),7.19-7.21(2H,m),7.30(1H,d,J=1.8),7.36(1H,d,J=7.9)7.45-7.50(4H,m),8.45-8.50(2H,m)
  Ⅰa-146 166-167℃,1H-NMR(CDCl3)δ2.41(3H,s),3.15(3H,s),3.84(3H,s),4.03(3H,s),5.16(2H,s),6.91(1H,d,J=8.5),7.02-7.06(2H,m),7.12(1H,d,J=8.5),7.20(1H,dd,J=1.8,8.5),7.30(1H,d,J=1.8),7.35(1H,d,J=7.9)7.45-7.49(3H,m),8.45-8.50(2H,m)
  Ⅰa-147 171-172℃1H-NMR(CDCl3)δ2.41(3H,s),3.09(3H,s),3.84(3H,s),4.03(3H,s),5.10(2H,s),6.94(2H,d,J=8.5),6.97-7.23(2H,m),7.29(1H,d,J=1.8),7.39(2H,d,J=8.5),7.45-7.49(3H,m),8.45-8.49(2H,m)
  Ⅰa-148 177-179℃,1H-NMR(CDCl3)δ2.39(8H,s),4.03(3H,s),5.27(2H,s),6.72(1H,dd,J=2.4,8.5),6.93(1H,d,J=1.8),7.12(1H,d,J=7.9),7.31-7.36(2H,m),7.46-7.49(3H,m),7.78(1H,dt,J=1.8,7.3),8.46-8.50(2H,m),8.68(1H,d,J=4.9),9.76(1H,s)
  Ⅰa-149 221-212℃,1H-NMR(CDCl3)δ2.39(3H,s),4.03(3H,s),5.19(2H,s)5.69(1H,s),6.78(1H,dd,J=1.8,7.9),6.92(1H,d,J=2.4),7.01(1H,d,J=8.5),7.35-7.40(1H,m),7.45-7.51(3H,m),7.80(1H,d,J=7.9),8.46-8.50(2H,m),8.65(1H,d,J=4.9),8.72(1H,s)
  Ⅰa-150 222-224℃,1H-NMR(CDCl3)δ2.39(3H,s),4.03(3H,s),5.19(2H,s),6.08(1H,s),6.75(1H,dd,J=1.8,7.9),6.92(1H,d,J=6.7),6.94(1H,s),7.35(2H,d,J=6.1),7.45-7.51(3H,m),8.25-8.50(2H,m),8.65(2H,d,J=5.5)
  Ⅰa-151 195-197℃,1H-NMR(CDCl3)δ2.41(3H,s),3.23(3H,s),4.03(3H,s),5.32(2H,s),7.13(1H,d,J=8.5),7.20(1H,dd,J=2.4,8.5),7.26-7.33(2H,m),7.46-7.50(3H,m),7.62(1H,d,J=7.3),7.78(1H,dt,J=1.8,7.9),8.45-8.50(2H,m),8.62(1H,d,J=4.9)
  Ⅰa-152 173-174℃,1H-NMR(CDCl3)δ2.42(3H,s),3.13(3H,s),4.03(3H,s),5.21(2H,s),7.15(1H,d,J=7.9),7.21(1H,d,J=1.8),7.31(1H,d,J=1.8),7.36-7.41(1H,m),7.47-7.89(3H,m),8.46-8.50(2H,m),8.73(1H,s),8.65(1H,d,J=4.9),8.73(1H,s)
  Ⅰa-153 186-187℃,1H-NMR(CDCl3)δ2.41(3H,s),3.20(3H,s),4.03(3H,s),5.22(2H,s),7.06(1H,d,J=8.5),7.21(1H,dd,J=1.8,8.5),7.32(1H,d,J=2.4),7.42(1H,d,J=6.1),7.47-7.50(3H,m),8.45-8.50(2H,m),8.68(2H,d,J=4.9)
  Ⅰa-154 112-113℃,1H-NMR(CDCl3)δ2.37(3H,s),3.16(2H,t,J=6.7),4.02(3H,s),4.32(2H,t,J=6.7),5.55(1H,s),6.74(1H,dd,J=1.8,8.5),6.85(1H,d,J=1.8),6.93(1H,d,J=8.5),7.25-7.39(5H,m),7.45-7.49(3H,m),8.45-8.49(2H,m)
                               表94
  Ⅰa-155 169-170℃,1H-NMR(CDCl3)δ2.39(3H,s),2.88(3H,s),3.18(2H,t,J=6.7),4.02(3H,s),4.35(2H,t,J=6.7),7.07(1H,d,J=8.5),7.19(1H,dd,J=1.8,7.9),7.25-7.38(6H,m),7.46-7.49(3H,m),8.44-8.49(2H,m)
  Ⅰa-156 117-119℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.39(3H,s),4.03(3H,s),4.62(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.75(1H,s),6.75(1H,dd,J=2.2,8.3),6.87(1H,d,J=2.2),6.94(1H,d,J=8.3),7.45-7.50(3H,m),8.46-8.49(2H,m)
  Ⅰa-157 121-124℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.42(3H,s),3.23(3H,s),3.40(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.07(1H,d,J=8.6),7.19(1H,dd,J=2.0,8.6),7.28(1H,d,J=2.0),7.45-7.50(3H,m),8.45-8.49(2H,m)
  Ⅰa-159 79-80℃,1H-NMR(CDCl3)δ1.75(3H,s),1.76(3H,s),2.38(3H,s),2.54(2H,q,J=6.7),4.03(3H,s),4.08(2H,t,J=6.7),5.23(1H,t,J=7.3),5.71(1H,s),6.74(1H,dd,J=1.8,7.9),6.87(1H,d,J=1.8),6.92(1H,d,J=7.9),7.44-7.51(3H,m),8.45-8.50(2H,m)
  Ⅰa-160 152-153℃,1H-NMR(CDCl3)δ1.69(3H,s),1.74(3H,s),2.41(3H,s),2.56(2H,q,J=6.7),3.21(3H,s),4.03(3H,s),4.08(2H,t,J=6.7),5.22(1H,t,J=6.7),7.06(1H,d,J=7.9),7.20(1H,dd,J=1.8,7.9),7.28(1H,d,J=1.8),7.46-7.50(3H,m),8.45-8.50(2H,m)
  Ⅰa-162 200.5-201.5℃,1H-NMR(CDCl3)δ2.38(3H,s),3.11(3H,s),4.01(3H,s),5.17(2H,s),5.38(1H,s),6.90(2H,d,J=8.8),7.13(1H,d,J=8.5),7.19(1H,dd,J=2.0,8.5),7.29(1H,d,J=2.0),7.37-7.49(5H,m),8.37(2H,d,J=8.8)
  Ⅰa-163 163-168℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.36(3H,s),4.01(3H,s),4.62(2H,d,J=6.6),5.53(1H,brt,J=6.6),5.58(1H,br),5.74(1H,brs),6.73(1H,dd,J=2.0,8.3),6.86(1H,d,J=2.0),6.89(2H,d,J=8.8),6.93(1H,d,J=8.3),8.37(2H,J=8.8)
  Ⅰa-167 185.5-186.5℃,1H-NMR(CDCl3)δ2.41(3H,s),3.11(3H,s),3.18(3H,s),4.02(3H,s),5.18(2H,s),7.15(1H,d,J=8.3),7.21(1H,dd,J=2.0,8.3),7.30(1H,d,J=2.0),7.36-7.49(7H,m),8.54(2H,d,J=8.8)
  Ⅰa-168 138-139℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.41(3H,s),3.18(3H,s),3.22(3H,s),4.02(3H,s),4.64(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.08(1H,d,J=8.5),7.19(1H,dd,J=2.0,8.5),7.28(1H,d,J=2.0),7.39(2H,d,J=9.0),8.54(2H,J=9.0)
  Ⅰa-173 202-204℃,1H-NMR(CDCl3)δ2.40(3H,s),2.55(3H,s),3.11(3H,s),4.02(3H,s),5.17(2H,s),7.14(1H,d,J=8.5),7.20(1H,dd,J=2.0,8.5),7.30(1H,d,J=2.0),7.33(2H,brd,J=8.6),7.37-7.50(5H,m),8.40(2H,brd,J=8.6)
  Ⅰa-175 205-206℃,1H-NMR(CDCl3)δ2.44(3H,s),3.10(3H,s),3.12(3H,s),4.05(3H,s),5.18(2H,s),7.16(1H,d,J=8.5),7.21(1H,dd,J=2.0,8.5),7.31(1H,d,J=2.0),7.37-7.50(5H,m),8.05(2H,brd,J=8.6),8.68(2H,brd,J=8.6)
  Ⅰa-176 178-179℃,1H-NMR(CDCl3)δ2.40(3H,s),3.11(3H,s),4.01(3H,s),5.17(2H,s),7.12-7.22(4H,m),7.29(1H,d,J=2.0),7.37-7.50(5h,m),8.48(2H,dd,J=5.6,9.0)
  Ⅰa-177 127-128℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.37(3H,s),4.01(3H,s),4.62(2H,d,J=6.8),5.53(1H,brt,J=6.8),5.74(1H,s),6.74(1H,dd,J=2.0,8.3),6.86(1H,d,J=2.0),6.94(1H,d,J=8.3),7.14(2H,d,J=8.8),8.48(2H,dd,J=5.6,8.8)
                            表95
    Ⅰa-178 143-144℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.40(3H,s),3.23(3H,s),4.02(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.05-7.20(4H,m),7.27(1H,d,J=2.2),8.48(2H,dd,J=5.6,9.0)
    Ⅰa-179 118-120℃,1H-NMR(CDCl3)δ2.43(3H,s),3.12(3H,s),4.05(3H,s),5.18(2H,s),7.15(1H,d,J=8.6),7.21(1H,dd,J=2.0,8.6),7.31(1H,d,J=2.0),7.38-7.50(5H,m),7.60(1H,brt,J=7.8),7.73(1H,br d,J=7.8),8.67(1H,brd,J=7.8),8.75(1H,brs)
    Ⅰa-180 114-115℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.40(3H,s),4.04(3H,s),4.63(2H,d,J=6.8),5.53(1H,brt,J=6.8),5.74(1H,s),6.75(1H,dd,J=2.0,8.3),6.87(1H,d,J=2.0),6.95(1H,d,J=8.3),7.60(1H,t,J=7.8),7.72(1H,brd,J=7.8),8.67(1H,brd,J=7.8),8.75(1H,s)
    Ⅰa-181 102-103℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.43(3H,s),3.23(3H,s),4.05(3H,s),4.64(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.08(1H,d,J=8.6),7.20(1H,dd,J=2.2,8.6),7.28(1H,d,J=2.2),7.60(1H,t,J=7.6),7.73(1H,d,J=7.6),8.67(1H,d,J=7.6),8.75(1H,s)
    Ⅰa-182 155-156℃,1H-NMR(CDCl3)δ2.41(3H,s),4.06(3H,s),5.17(2H,s),5.75(1H,s),6.76(1H,dd,J=2.0,8.3),6.90(1H,d,J=2.0),7.02(1H,d,J=8.3),7.40-7.48(5H,m),7.65(1H,t,J=8.1),8.31(1H,ddd,J=1.2,2.5,8.1),8.83(1H,ddd,J=1.2,1.5,8,1),9.31(1H,dd,J=1.5,2.5)
    Ⅰa-183 160-167℃,1H-NMR(CDCl3)δ2.44(3H,s),3.12(3H,s),4.06(3H,s),5.19(2H,s),7.16(1H,d,J=8.5),7.22(1H,dd,J=2.2,8.5),7.31(1H,d,J=2.2),7.38-7.49(5H,m),7.65(1H,t,J=8.1),8.32(1H,ddd,J=1.2,2.4,8.3),8.83(1H,ddd,J=1.2,1.5,8,3),9.31(1H,dd,J=1.5,2.4)
    Ⅰa-184 153-155℃,1H-NMR(CDCl3)2.40(3H,s),3.11(3H,s),4.02(3H,s),5.17(2H,s),6.81(1H,ddd,J=1.2,2.5,7.8),7.14(1H,d,J=8.5),7.20(1H,dd,J=2.2,8.5),7.27(1H,t,J=7.8),7.30(1H,d,J=2.2),7.37-7.48(5H,m),7.81(1H,dd,J=1.5,2.5),7.88(1H,ddd,J=1.2,1.5,7.8)
    Ⅰa-185 143-144℃,1H-NMR(CDCl3)δ2.22(3H,s),2.40(3H,s),3.11(3H,s),4.03(3H,s),5.17(2H,s),7.14(1H,d,J=8.6),7.21(1H,dd,J=2.0,8.6),7.30(1H,d,J=2.0),7.31(1H,s),7.37-7.48(6H,m),7.91(1H,br d,J=81),8.23(1H,brd,J=8.1),8.35(1H,brs)
    Ⅰa-186 171-172℃,1H-NMR(CDCl3)δ2.40(3H,s),3.05(3H,s),3.12(3H,s),4.02(3H,s),5.18(2H,s),6.59(1H,brs),7.14(1H,d,J=8.6),7.20(1H,dd,J=2.0,8.6),7.30(1H,d,J=2.0),7.37-7.52(7H,m),8.24(1H,br s),8.31(1H,brd,J=6.8)
    Ⅰa-187 165-167℃,1H-NMR(CDCl3)1.77(3H,s),1.83(3H,s),2.39(3H,s),3.05(3H,s),4.03(3H,s),4.6(2H,d,J=6.8),5.5(1H,brt,J=6.8),5.74(1H,s),6.45(1H,brs),6.73(1H,dd,J=2.2,8.3),6.86(1H,d,J=2.2),6.941H,d,J=8.3),7.45-7.52(2H,m),8.24(1H,m),8.30-8.34(1H,m)
    Ⅰa-188 150-151℃,1H-NMR(CDCl3)δ1.58(3H,s),1.67(3H,s),2.41(3H,s),2.96(3H,s),3.12(3H,s),4.03(3H,s),4.36(2H,d,J=7.3),5.18(2H,s),5.291H,brt,J=7.3),7.15(1H,d,J=8.6),7.20(1H,dd,J=2.0,8.6),7.29(1H,d,J=2.0),7.37-7.48(7H,m),8.42-8.45(2H,m)
    Ⅰa-189 91-94℃,1H-NMR(CDCl3)1.58(3H,s),1.67(3H,s),1.77(3H,s),1.83(3H,s),2.38(3H,s),2.96(3H,s),4.02(3H,s),4.36(2H,d,J=6.8),4.62(2H,d,J=6.8),5.29(1H,brt,J=6.8),5.52(1H,brt,J=6.8),5.76(1H,s),6.73(1H,dd,J=2.2,8.3),6.86(1H,d,J=2.2),6.94(1H,d,J=8.3),7.45-7.51(2H,m),8.42-8.46(2H.m)
                         表96
   Ⅰa-190 110-111℃,1H-NMR(CDCl3)δ1.58(3H,s),1.67(3H,s),1.77(3H,s),1.82(3H,s),2.41(3H,s),2.97(3H,s),3.23(3H,s),4.02(3H,s),4.36(2H,d,J=7.1),4.64(2H,d,J=7.1),5.29(1H,brt,J=7.1),5.51(1H,brt,J=7.1),7.08(1H,d,J=8.5),7.19(1H,dd,J=2.0,8.5),7.27(1H,d,J=2.0)7.46-7.52(2H,m),8.43(2H,m)
   Ⅰa-191 131-132℃
   Ⅰa-192 171.5-172℃,1H-NMR(CDCl3)δ2.40(3H,s),3.11(3H,s),3.89(3H,s)5.18(2H,s),7.15(1H,d,J=8.6),7.22(1H,dd,J=2.0,8.6),7.30(1H,d,J=2.0),7.38-7.50(5H,m),7.56(1H,ddd,J=1.5,7.6,7.6),7.66(1H,ddd,J=1.5,7.6,7.6),7.73(1H,dd,J=1.5,7.6),8.17(1H,dd,J=1.5,7.6)
   Ⅰa-194 249-251℃,1H-NMR(CDCl3)δ2.27(3H,s),2.45(3H,s),3.12(3H,s),4.05(3H,s),5.30(2H,s),7.13-7.24(3H,m),7.31(1H,d,J=2.0),7.38-7.50(6H,m),8.62(1H,dd,J=1.7,8.3),8.73(1H,brd,J=8.1),13.18(1H,brs)
   Ⅰa-195 180-181℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.27(3H,s),2.42(3H,s),4.04(3H,s),4.63(2H,d,J=6.8),5.53(1H,brt,J=6.8),5.77(1H,s),6.76(1H,dd,J=2.0,8.3),6.88(1H,d,J=2.0),6.96(1H,d,J=8.3),7.16(1H,ddd,J=1.2,7.0,8.1),7.46(1H,ddd,J=1.7,7.0,8.5),8.63(1H,dd,J=1.7,8.1),8.73(1H,brd,J=8.5),13.28(1H,brs)
   Ⅰa-196 169-170℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.27(3H,s),2.45(3H,s),3.23(3H,s),4.04(3H,s),4.65(2H,d,J=6.8),5.52(1H,brt,J=6.8),7.16(1H,ddd,J=1.2,7.3,8.1),7.22(1H,dd,J=2.2,8.6),7.29(1H,d,J=2.2),7.47(1H,ddd,J=1.5,7.3,8.1),8.62(1H,dd,J=1.5,8.1),8.73(1H,brd,J=8.1),13.21(1H,brs)
   Ⅰa-197 176-178℃,1H-NMR(CDCl3)δ2.45(3H,s),3.03(3H,s),3.12(3H,s),4.05(3H,s),5.18(2H,s),7.14-7.24(3H,m),7.30(1H,d,J=2.0),7.38-7.51(6H,m),7.76(1H,dd,J=1.0,8.3),8.69(1H,dd,J=1.7,8.1),13.19(1H,brs)
   Ⅰa-199 157-158℃,1H-NMR(CDCl3)δ1.36(3H,t,J=6.7),2.42(3H,s),3.11(3H,s),4.54(2H,q,J=6.7),5.18(2H,s),7.14(1H,d,J=7.9),7.21(1H,dd,J=1.8,8.5),7.32(1H,d,J=2.4),7.37-7.49(8H,m),8.43-8.48(2H,m)
   Ⅰa-200 122-123℃,1H-NMR(CDCl3)δ1.36(3H,t,J=7.3),2.39(3H,s),2.40(3H,s),4.54(2H,q,J=7.3),5.11(2H,s),5.69(1H,s),6.76(1H,dd,J=1.8,8.5),6.89(1H,d,J=1.8),7.00(1H,d,J=8.5),7.22-7.50(3H,m),8.42-8.48(2H,m)
   Ⅰa-201 147-148℃,1H-NMR(CDCl3)δ1.36(3H,t,J=6.7),2.39(3H,s),2.42(3H,s),3.10(3H,s),4.54(2H,q,J=6.7),5.13(2H,s),7.14(1H,d,J=8.5),7.18-7.28(3H,m),7.31(1H,d,J=1.8),7.36(2H,d,J=8.5),7.46-7.50(3H,m),8.43-8.48(2H,m)
   Ⅰa-202 99-100℃,1H-NMR(CDCl3)δ1.36(3H,s),1.77(3H,s),1.83(3H,s),2.39(3H,s),4.54(2H,q,J=7.3),4.62(2H,d,J=6.7),5.53(1H,brt,J=6.7),5.72(1H,s),6.75(1H,dd,J=24,8.5),6.87(1H,d,J=2.4),6.93(1H,d,J=8.5),7.42-7.52(3H,m),8.42-8.50(2H,m)
   Ⅰa-203 128-129℃,1H-NMR(CDC13)δ1.37(3H,t,J=6.7),1.77(3H,s),1.82(3H,s),2.42(3H,s),3.22(3H,s),5.34(2H,q,J=6.7),4.63(2H,d,J=6.7),5.51(1H,brt,J=6.7),7.06(1H,d,J=8.5),7.20(1H,dd,J=2.4,8.5),7.30(1H,d,J=1.8),7.45-7.49(3H,m),8.43-8.48(2H,m)
   Ⅰa-206 oil,1H-NMR(CDCl3)δ1.33(6H,d,J=6.1),2.38(3H,s),5.16(2H,s),5.55(1H,sept,J=6.1),5.68(1H,s),6.75(1H,dd,J=1.8,8.5),6.89(1H,d,J=1.8),6.99(1H,d,J=8.5),7.36-7.48(8H,m),8.42-8.47(2H,m)
                         表97
   Ⅰa-207 123-124℃,1H-NMR(CDCl3)δ1.33(3H,s),1.36(3H,s),2.41(3H,s),3.11(3H,s),5.18(2H,s),5.55(1H,七峰,J=6.1),7.13(1H,d,J=8.5),7.20(1H,dd,J=1.8,8.5),7.31(1H,d,J=1.8),7.37-7.50(8H,m),8.42-8.46(2H,m)
   Ⅰa-208 157-158℃,1H-NMR(CDCl3)δ1.32(3H,s),1.34(3H,s),2.38(3H,s),2.40(3H,s),5.11(2H,s),5.55(1H,七峰,J=6.1),5.68(1H,s),6.75(1H,dd,J=2.4,8.5),6.88(1H,d,J=2.4),6.99(1H,d,J=8.5),7.24(1H,d,J=7.9),7.36(2H,d,J=7.9),7.45-7.52(3H,m),8.42-8.47(2H,m)
   Ⅰa-209 159-160℃,1H-NMR(CDCl3)δ1.33(3H,s),1.35(3H,s),2.39(3H,s),2.41(3H,s),3.10(3H,s),5.13(2H,s),5.55(1H,七峰,J=6.1),7.13(1H,d,J=7.9),7.18(1H,d,J=1.8),7.23(1H,d,J=7.3),7.30(1H,d,J=1.8),7.36(2H,d,J=7.9),7.44-7.49(3H,m),8.42-8.46(2H,m)
   Ⅰa-210 113-114℃,1H-NMR(CDCl3)δ1.32(3H,s),1.34(3H,s),1.77(3H,s),1.83(3H,s),2.38(3H,s),4.62(2H,d,J=7.3),5.49-5.59(2H,m),5.70(1H,s),6.73(1H,dd,J=2.4,8.5),6.86(1H,d,J=2.4),6.92(1H,d,J=8.5),7.45-7.50(3H,m),8.42-8.46(2H,m)
   Ⅰa-211 128-129℃,1H-NMR(CDCl3)δ1.33(3H,s),1.35(3H,s),1.77(3H,s),1.82(3H,s),2.41(3H,s),3.22(3H,s),4.64(2H,d,J=6.7),5.49-5.60(2H,m),7.05(1H,d,J=8.5),7.18(1H,dd,J=1.8,8.5),7.29(1H,d,J=2.4),7.45-7.49(3H,m),8.42-8.46(2H,m)
   Ⅰa-214 110-111℃,1H-NMR(CDCl3)δ1.24(3H,t,J=7.6),2.65(2H,q,J=7.6),4.02(3H,s),5.16(2H,s),5.71(1H,s),6.74(1H,dd,J=2.0,8.3),6.88(1H,d,J=2.0),7.01(1H,d,J=8.3),7.41-7.49(8H,m),8.48-8.53(2H,m)
   Ⅰa-215 161-162℃,1H-NMR(CDCl3)δ1.25(3H,t,J=7.6),2.66(2H,q,J=7.6),3.11(3H,s),4.02(3H,s),5.17(2H,s),7.14(1H,d,J=8.5),7.18(1H,dd,J=2.0,8.5),7.28(1H,d,J=2.0),7.37-7.49(8H,m),8.49-8.53(2H,m)
   Ⅰa-216 121-122℃,1H-NMR(CDCl3)δ1.24(3H,t,J=7.6),2.40(3H,s),2.65(2H,q,J=7.6),4.02(3H,s),5.11(2H,s),5.70(1H,s),6.74(1H,dd,J=2.0,8.3),6.87(1H,d,J=2.0),7.01(1H,d,J=8.3),7.24(2H,d,J=8.1),7.34(2H,d,J=8.1),7.46-7.50(3H,m),8.49-8.53(2H,m)
   Ⅰa-217 184-185℃,1H-NMR(CDCl3)δ1.25(3H,t,J=7.6),2.39(3H,s),2.66(2H,q,J=7.6),3.10(3H,s),4.02(3H,s),5.13(2H,s),7.14(1H,d,J=8.6),7.18(1H,dd,J=2.0,8.6),7.22(2H,d,J=7.8),7.27(1H,d,J=2.0),7.36(2H,d,J=7.8),7.47-7.51(3H,m),8.49-8.53(2H,m)
   Ⅰa-218 119-120℃,1H-NMR(CDCl3)δ1.24(3H,t,J=7.6),1.77(3H,s),1.83(3H,s),2.65(2H,q,J=7.6),4.02(3H,s),4.62(2H,d,J=6.8),5.51(1H,brt,J=6.8),5.73(1H,s),6.73(1H,dd,J=2.0,8.3),6.85(1H,d,J=2.0),6.94(1H,d,J=8.3),7.46-7.50(3H,m),8.49-8.53(2H,m)
   Ⅰa-219 141-142℃,1H-NMR(CDCl3)δ1.25(3H,t,J=7.6),1.77(3H,s),1.82(3H,s),2.66(2H,q,J=7.6),3.22(3H,s),4.02(3H,s),4.63(2H,d,J=6.6),5.51(1H,brt,J=6.6),7.07(1H,d,J=8.5),7.17(1H,dd,J=2.0,8.5),7.26(1H,d,J=2.0),7.46-7.50(3H,m),8.49-8.53(2H,m)
   Ⅰa-222 187-189℃,1H-NMR(CDCl3)δ5.18(2H,s),5.76(1H,s),6.93(1H,dd,J=2.2,8.3),7.04(1H,d,J=8.6),7.05(1H,d,J=2.2),7.42-7.58(8H,m),8.45-8.49(2H,m),8.97(1H,s)
   Ⅰa-223 163-166℃,1H-NMR(CDCl3)δ3.13(3H,s),5.21(2H,s),7.19(1H,d,J=8.5),7.36(1H,dd,J=2.0,8.5),7.38-7.54(9H,m),8.45-8.49(2H,m),8.99(2H,s)
                         表98
   Ⅰa-224 165-166℃,1H-NMR(CDCl3)δ1.78(3H,s),1.83(3H,s),4.65(2H,d,J=6.8),5.53(1H,t,J=6.8),5.77(1H,s),6.92(1H,dd,J=2.0,8.3),6.97(1H,d,J=8.3),7.02(1H,d,J=2.0),7.54-7.58(3H,m),8.45-8.48(2H,m),8.97(1H,s)
   Ⅰa-226 118-119℃,1H-NMR(CDCl3)δ3.87(3H,s),5.17(2H,s),5.79(1H,s),6.88(1H,dd,J=2.2,8.3),7.01(1H,d,J=8.3),7.03(1H,d,J=2.2),7.39-7.52(8H,m),8.48-8.51(2H,m),8.90(1H,s)
   Ⅰa-227 117-118℃,1H-NMR(CDCl3)δ3.13(3H,s),3.90(3H,s),5.19(2H,s),5.79(1H,s),7.18(1H,d,J=8.6),7.33(1H,dd,J=2.2,8.3),7.40(1H,d,J=2.2),7.41-7.53(8H,m),8.48-8.52(2H,m),8.90(1H,s)
   Ⅰa-229 92-94℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),3.87(3H,s),4.63(2H,d,J=6.8),5.51(1H,t,J=6.8),5.78(1H,s),6.88(1H,dd,J=2.0,8.3),6.95(1H,d,J=8.3),7.00(1H,d,J=2.0),7.49-7.51(3H,m),8.47-8.51(2H,m),8.90(1H,s)
   Ⅰa-230 134-135℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.23(3H,s),3.91(3H,s),4.65(2H,d,J=6.6),5.49(1H,t,J=6.6),7.11(1H,d,J=8.3),7.32(1H,dd,J=2.0,8.3),7.37(1H,d,J=2.0),7.49-7.54(3H,m),8.48-8.52(2H,m),8.90(1H,s)
   Ⅰa-232 151-152℃,1H-NMR(CDCl3)δ2.14(3H,s),3.13(3H,s),5.21(2H,s),7.19(1H,d,J=8.5),7.28(1H,dd,J=2.2,8.5),7.38-7.52(9H,m),8.46-8.49(2H,m),8.70(2H,s)
   Ⅰa-233 197-198℃,1H-NMR(CDCl3)δ2.32(3H,s),2.60(3H,s),3.11(3H,s),5.19(2H,s),7.18(2H,brs),7.28(1H,m),7.38-7.50(8H,s),8.49-8.53(2H,m)
   Ⅰa-235 184-185℃,1H-NMR(CDCl3)δ2.23(3H,s),3.04(3H,d,J=4.6),4.55(1H,brq,J=4.6),5.17(2H,s),5.82(1H,s),6.71(1H,dd,J=2.0,8.1),6.85(1H,d,J=2.0),7.04(1H,d,J=8.1),7.39-7.48(8H,m),8.44-8.48(2H,m)
   Ⅰa-236 204-205℃,1H-NMR(CDCl3)δ2.23(3H,s),3.05(3H,d,J=4.6),3.13(3H,s),4.51(1H,brq,J=4.6),5.19(2H,s),7.16(1H,dd,J=2.0,8.6),7.19(1H,d,J=8.6),7.25(1H,d,J=2.0),7.38-7.50(8H,m),8.44-8.48(2H,m)
   Ⅰa-238 oil,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.35(3H,s),3.99(3H,s),4.66(2H,d,J=6.7),4.78(1H,s),5.51(1H,brt,J=6.7),5.69(1H,s),6.91(2H,d,J=8.6),8.95(1H,d,J=8.6),8.01(1H,dd,J=8.6,1.8),8.07(1H,d,J=1.8)
   Ⅰa-239 189-190℃1H-NMR(CDCl3)δ2.34(3H,s),3.21(3H,s),3.99(3H,s),5.20(2H,s),5.70(1H,s),7.02(1H,d,J=8.6),7.31-7.47(9H,m),8.03(1H,dd,J=8.6,1.8),8.10(1H,d,J=1.8)
   Ⅰa-240 190-192℃,1H-NMR(CDCl3)δ2.34(3H,s),3.12(3H,s),3.21(3H,s),4.00(3H,s),5.21(2H,s),7.14(1H,d,J=8.6),7.28-7.49(9H,m),8.41(1H,dd,J=8.6,2.5),8.44(1H,d,J=2.5)
   Ⅰa-241 72-74℃,1H-NMR(CDCl3)δ1.78(3H,s),1.81(3H,s),2.34(3H,s),3.21(3H,s),3.24(3H,s),4.01(3H,s),4.67(2H,d,J=6.7),5.50(1H,brt,J=6.7),7.08(1H,d,J=8.6),7.28-7.39(4H,m),8.39(1H,dd,J=8.5,1.8),8.42(1H,s)
   Ⅰa-248 228-230℃,1H-NMR(CDCl3)δ5.21(2H,s),7.08(1H,d,J=9.0),7.38-7.56(8H,m),7.72-7.76(2H,m),7.85和7.88(各为1H,Abq,J=9.0),8.13-8.16(2H,m)
   Ⅰa-249 220-221℃,1H-NMR(CDCl3)δ3.15(3H,s),5.23(2H,s),7.24(1H,d,J=8.8),7.37-7.58(8H,m),7.89和7.93(各为1H,Abq,J=9.0),8.07(1H,d,J=2.2),814-8.17(2H,m),8.21(1H,dd,J=2.2,8.8)
                                 表99
   Ⅰa-252 185-186℃,1H-NMR(CDCl3)δ1.78(3H,s),1.82(3H,s),4.66(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.66(1H,brs),5.78(1H,s),6.99-7.03(3H,m),7.68(2H,d,J=9.0),7.72(1H,dd,J=2.2,8.6),7.82(2H,s),8.06(2H,d,J=8.8)
   Ⅰa-253 198-200℃,1H-NMR(CDCl3)δ3.15(3H,s),3.21(3H,s),5.23(2H,s),7.24(1H,d,J=8.8),7.38-7.46(5H,m),7.47(2H,d,J=9.0),7.91(2H,s),8.07(1H,d,J=2.2),8.19(1H,dd,J=2.2,8.8),8.22(2H,d,J=9.0)
   Ⅰa-254 192-193℃,1H-NMR(CDCl3)δ1.78(3H,s),1.82(3H,s),3.21(3H,s),3.25(3H,s),4.69(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.18(1H,d,J=8.8),7.48(2H,d,J=9.0),7.90(2H,s),8.03(1H,d,J=2.2),8.22(1H,dd,J=2.2,8.8),8.23(2H,d,J=8.8)
   Ⅰa-255 233-235℃,1H-NMR(CDCl3)δ3.89(3H,s),5.21(2H,s),5.75(1H,s),7.05(2H,d,J=8.8),7.08(1H,d,J=9.0),7.37-7.47(5H,m),7.73-7.75(2H,m),7.81和7.83(各为1H,ABq,J=9.3),8.12(2H,d,J=8.8)
   Ⅰa-256 212-215℃,1H-NMR(CDCl3)δ3.15(3H,s),3.89(3H,s),5.23(2H,s),7.07(2H,d,J=9.0),7.23(1H,d,J=8.8),7.37-7.50(5H,m),7.84和7.86(各为1H,ABq,J=9.3),8.05(1H,d,J=2.0),8.12(2H,d,J=9.0),8.18(1H,dd,J=2.0,8.8)
   Ⅰa-257 171-174℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.89(3H,s),4.66(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.78(1H,s),7.01(1H,d,J=8.3),7.05(2H,d,J=8.8),7.69(1H,d,J=2.2),7.73(1H,dd,J=2.2,8.3),7.81和7.82(各为1H,ABq,J=9.0),8.11(2H,d,J=8.8),
   Ⅰa-258 197-199℃,1H-NMR(CDCl3)δ1.78(3H,s),1.82(3H,s),3.25(3H,s),3.90(3H,s),4.68(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.06(2H,d,J=9.0),7.17(1H,d,J=8.8),7.84和7.85(各为1H,ABq,J=9.3),800(1H,d,J=2.2),8.12(2H,d,J=9.0),8.20(1H,dd,J=2.2,8.8)
   Ⅰa-269 198-199℃,1H-NMR(CDCl3)δ4.83(1H,brs),5.14(2H,s),5.69(1H,s),6.85(2H,d,J=8.8),6.92(1H,d,J=8.3),7.09(1H,dd,J=2.2,8.3),7.13和7.14(各为1H,ABq,J=3.9),7.23(1H,d,J=2.2),7.38-7.45(5H,m),7.49(2H,d,J=8.8)
   Ⅰa-271 167-168℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),4.60(2H,d,J=6.8),4.79(1H,s),5.50(1H,brt,J=6.8),5.71(1H,s),6.85(2H,d,J=8.8),6.87(1H,d,J=8.3),7.09(1H,dd,J=2.2,8.3),7.12和7.14(各为1H,ABq,J=3.7),7.20(1H,d,J=2.2),7.50(2H,d,J=8.8)
   Ⅰa-272 162-164℃,1H-NMR(CDCl3)δ3.12(3H,s),3.17(3H,s),5.16(2H,s),7.08(1H,d,J=8.6),7.21(1H,d,J=3.7),7.25(1H,d,J=3.7),7.31(2H,d,J=8.8),7.39-7.44(5H,m),7.48(1H,dd,J=2.2,8.6),7.57(1H,d,J=2.2),7.64(2H,d,J=8.8)
   Ⅰa-273 128-129℃,1H-NMR(CDCl3)δ1.76(3H,s),1.80(3H,s),3.17(3H,s),3.233H,s),4.62(2H,d,J=6.8),5.48(1H,brt,J=6.8),7.02(1H,d,J=8.5),7.20(1H,d,J=3.9),7.25(1H,d,J=3.9),7.31(2H,d,J=8.8),7.48(1H,dd,J=2.2,8.5),7.56(1H,d,J=2.2),7.64(2H,d,J=8.8)
   Ⅰa-275 165-166℃,1H-NMR(CDCl3)δ5.14(4H,s),5.69(2H,s),6 92(2H,d,J=8.3),7.09(2H,dd,J=2.2,8.3),7.14(2H,s),7.22(2H,d,J=2.2),7 37-7.44(10H,m)
   Ⅰa-280 178-179℃,1H-NMR(CDCl3)δ2.31(3H,s),3.11(3H,s),4.82(1H,s),5.16(2H,s),6.84(2H,d,J=8.8),7.01(1H,s),7.10(1H,d,J=8.6),7.34-7.48(9H,m)
                                表100
   Ⅰa-281 128-129℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.31(3H,s),4.61(2H,d,J=6.8),4.81(1H,s),5.51(1H,brt,J=6.8),5.72(1H,s),6.83(2H),d,J=8.8),6.90(1H,d,J=8.3),6.96(1H,dd,J=2.2,8.3),7.00(1H,s),7.08(1H,d,J=2.2),7.47(2H,d,J=8.8)
   Ⅰa-282 133-134℃,1H-NMR(CDCl3)δ2.33(3H,s),3.12(3H,s),3.17(3H,s),5.17(2H,s),7.11(1H,d,J=8.6),7.12(1H,s),7.30(2H,d,J=8.8),7.35-7.48(7H,m),7.61(2H,d,J=8.8)
   Ⅰa-283 86-87℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.33(3H,s),3.17(3H,s),3.22(3H,s),4.63(2H,d,J=6.8),5.49(1H,brt,J=6.8),7.05(1H,d,J=8.6),7.11(1H,s),7.29(2H,d,J=8.6),7.36(1H,dd,J=2.2,8.6),7.44(1H,d,J=2.2),7.61(2H,d,J=8.8)
   Ⅰa-309 128-129℃,1H-NMR(CDCl3)δ2.31(3H,s),3.64(3H,s),5.15(2H,s),5.70(1H,s),6.92(1H,dd,J=2.0,8.3),6.98(1H,d,J=8.3),7.07(1H,d,J=2.0),7.28(1H,brt,J=7.6),7.38-7.47(7H,m),7.71(2H,brd,J=7.6)
   Ⅰa-310 132-133℃,1H-NMR(CDCl3)δ2.34(3H,3),3.11(3H,s),3.65(3H,s),5.16(2H,s),7.13(1H,d,J=8.5),7.29-7.48(m,10H),7.70(2H,brd,J=7.6)
   Ⅰa-311 148-149℃,1H-NMR(CDCl3)δ2.30(3H,s),2.39(3H,s),3.64(3H,s),5.10(2H,s),5.69(1H,s),6.92(1H,dd,J=2.0,8.3),6.99(1H,d,J=8.3),7.06(1H,d,J=2.0),7.23(2H,d,J=8.1),7.30(1H,m),7.33(2H,d,J=8.1),7.43(2H,brt,J=8.1),7.68-7.72(2H,m)
   Ⅰa-312 146-147℃,1H-NMR(CDCl3)δ2.33(3H,s),2.38(3H,s),3.11(3H,s),3.653H,s),5.16(2H,s),7.13(1H,d,J=8.6),7.22(2H,d,J=8.1),7.29-7.477H,m),7.68-7.72(2H,M)
   Ⅰa-313 78-79℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.33(3H,s),3.22(3H,s),3.65(3H,s),4.62(2H,d,J=6.8),5.50(1H,brt,J=6.8),7.06(1H,d,J=8.6),7.29-7.47(5H,m),7.68-7.72(2H,m)
   Ⅰa-314 120-121℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.30(3H,s),3.64(3H,s),4.61(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.72(1H,s),6.91(2H,brs),7.04(1H,brs),7.27(1H,brt,J=7.3),7.43(2H,brt,J=8.3),7.70-7.73(2H,m)
   Ⅰa-315 136-137℃,1H-NMR(CDCl3)δ2.31(3H,s),3.62(3H,s),3.84(3H,s),5.16(2H,s),5.71(1H,s),6.91-7.01(4H,m),7.07(1H,d,J=1.8),7.37-7.48(5H,m),7.61(2H,d,J=8.9)
   Ⅰa-316 120-121℃,1H-NMR(CDCl3)δ2.32(3H,s),3.11(3H,s),3.63(3H,s),3.843H,s),5.16(2H,s),6.96(2H,d,J=8.9),7.13(1H,d,J=6.8),7.32-7.49(7H,m),7.59(2H,d,J=8.9)
   Ⅰa-317 130-131℃,1H-NMR(CDCl3)δ2.30(3H,s),2.39(3H,s),3.62(3H,s),3.84(3H,s),5.10(2H,s),5.70(1H,s),6.89-7.00(2H,m),6.96(2H,d,J=9.2),7.06(1H,d,J=1.8),7.23(2H,d,J=7.9),7.34(2H,d,J=7.9),7.57(2H,d,J=9.2)
   Ⅰa-318 145-146℃,1H-NMR(CDCl3)δ2.33(3H,s),2.38(3H,s),3.10(3H,s),3.63(3H,s),3.85(3H,s),5.11(2H,s),6.97(2H,d,J=8.5),7.12(1H,d,J=8.5),7.22(2H,d,J=7.9),7.34(1H,d,J=8.5),7.35(2H,d,J=7.9),7.46(1H,d,J=1.8),7.57(2H,d,J=8.5)
   Ⅰa-319 113-114℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.30(3H,s),3.62(3H,s),3.84(3H,s),4.60(2H,d,J=6.7),5.52(1H,brt,J=6.7),6.91(2H,d,J=1.2),6.96(2H,d,J=9.2),7.04(1H,s),7.58(2H,d,J=9.2)
                             表101
   Ⅰa-320 66-67℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2 32(3H,s),3.22(3H,s),3.63(3H,s),3.85(3H,s),4.62(2H,d,J=6.1),5.50(1H,brt,J=6.1),6.97(2H,d,J=8.5),7.05(1H,d,J=8.5),7.34(1H,dd,J=1.8,8.5),7.44(1H,d,J=1.8),7.57(2H,d,J=8.5)
   Ⅰa-322 152-153℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.24(3H,s),3.44(1H,br),3.84(3H,s),4.60(2H,d,J=6.7),5.51(1H,brt,J=6.7),6.78-6.94(5H,m),7.33(2H,d,J=8.5)
   Ⅰa-323 油，1H-NMR(CDCl3)δ0.96(3H,t,J=7.3),2.27(3H,s),3.82(3H,s),4.06(2H,q,J=7.3),5.13(2H,s),6.18(1H,dd,J=1.8,7.9),6.91-6.97(4H,m),7.32-7.45(7H,m)
   Ⅰa-324 108-109℃,1H-NMR(CDCl3)δ0.97(3H,t,J=7.3),2.28(3H,s),3.12(3H,s),3.85(3H,s),4.07(2H,q,J=7.3),5.17(2H,s),6.96(1H,d,J=6.7),7.11(1H,d,J=8.5),7.24-7.49(9H,m)
   Ⅰa-325 油，1H-NMR(CDCl3)δ0.99(3H,t,J=7.3),1.76(3H,s),1.82(3H,s),2.28.(3H,s),3.84,(3H,s),4.07(2H,q,J=7.3),4.61(2H,brd,J=6.7),5.51(1H,brt,J=6.7),5.78(1H,d,J=1.8),6.82(1H,dd,J=1.8,8.5),6.89-6.98(4H,m),7.36(2H,d,J=8.5)
   Ⅰa-326 85-86℃,1H-NMR(CDCl3)δ0.99(3H,t,J=7.3),1.76(3H,s),1.81(3H,s),2.28(3H,s),3.22(3H,s),3.85(3H,s),4.07(2H,q,J=7.3),4.63(2H,d,J=6.7),5.50(1H,brt,J=6.7),6.96(2H,d,J=8.6),7.04(1H,d,J=8.6),7.24-7.29(1H,m),7.33-7.37(3H,m)
   Ⅰa-328 140-141℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),2.34(3H,s),3.85(3H,s),4.52(2H,d,J=3.1),4.62(2H,d,J=6.7),5.52(1H,brt,J=6.7),5.78(1H,s),6.84-7.02(5H,m),7.58(2H,d,J=8.6)
   Ⅰa-334 136-137℃,1H-NMR(CDCl3)δ2.13(3H,s),3.80(3H,s),5.18(2H,s),5.85(1h,s),6.83(1H,dd,J=2.0,8.3),6.96(1H,d,J=2.0),7.04(1H,d,J=8.3),7.32-7.46(8H,m),7.69-7.73(2H,m)
   Ⅰa-335 165-165.5℃,1H-NMR(CDCl3)δ2.15(3H,s),3.13(3H,s),3.82(3H,s),5.20(2H,s),7.19(1H,d,J=8.3),7.27(1H,dd,J=2.2,8.3),7.33(1H,m),7.35(1H,d,J=2.2),7.38-7.50(7H,m),7.67-7.71(2H,m)
   Ⅰa-336 143-144℃,1H-NMR(CDCl3)δ1.78(3H,s),1.83(3H,s),2.14(3H,s),3.80(3H,s),4.64(2H,d,J=6.8),5.53(1H,brt,J=6.8),5.84(1H,s),6.82(1H,dd,J=2.2,8.3),6.93(1H,d,J=2.2),6.97(1H,d,J=8.3),7.32(1H,m),7.43(2H,m),7.69-7.73(2H,m)
   Ⅰa-337 126.5-127.5℃,1H-NMR(CDCl3)δ1.78(3H,s),1.83(3H,s),2.15(3H,s),3.24(3H,s),3.82(3H,s),4.66(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.12(1H,d,J=8.5),7.26(1H,dd,J=2.2,8.5),7.32(1H,m),7.33(1H,d,J=2.2),7.43(2H,m),7.67-7.71(2H.m)
   Ⅰa-338 167-168℃1H-NMR(CDCl3)δ5.17(2H,s),5.75(1H,s),6.99(1H,d,J=8.6),7.22(1H,dd,J=2.4,8.6),7.32(2H,s),7.33-7.52(8H,m),8.06-8.11(2H,m)
   Ⅰa-339 149-150℃1H-NMR(CDCl3)δ3.13(3H,s),5.18(2H,s),7.14(1H,d,J=8 5),7.37-7.50(8H,m),7.60(1H,dd,J=1.8,8.5),7.68(1H,d,J=1.8),8.07-8.12(2H,m)
   Ⅰa-340 184-186℃,1H-NMR(CDCl3)δ2.38(3H,s),5.12(2H,s),5.77(1H,s),6.99(1H,d,J=8.6),7.19-7.34(7H,m),7.40-7.52(3H,m),8.05-8.13(2H,m)
   Ⅰa-341 175-176℃,1H-NMR(CDCl3)δ2.38(3H,s),3.12(3H,s),5.14(2H,s),7.14(1H,d,J=8.5),7.22(2H,d,J=7.9),7.34(2H,d,J=7.9),7.37(1H,s),7.47(2H,d,J=1.8),7.49(1H,d,J=2.4),7.60(1H,dd,J=2.4,8.5),8.06-8.12(2H,m)
                          表102
   Ⅰa-342 131-132℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),4.63(2H,d,J=6.7),5.50(1H,brt,J=6.7),5.78(1H,s),6.92(1H,d,J=8.5),7.22(1H,dd,J=2.4,8.5),7.30-7.32(2H,m),7.43-7.51(3H,m),8.07-8.11(2H,m)
   Ⅰa-343 126-127℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),3.25(3H,s),4.64(2H,d,J=6.7),5.49(1H,brt,J=6.7),7.07(1H,d,J=8.6),7.37(1H,s),7.45-7.53(3H,m),7.60(1H,dd,J=1.8,8.6),7.66(1H,d,J=2.4),8.08-8.12(2H,m)
   Ⅰa-348 150-151℃,1H-NMR(CDCl3)δ3.85(3H,s),5.16(2H,s),5.71(1H,s),6.98(4H,d,J=8.9),7.31-7.46(6H,m),7.82(1H,s),8.04(2H,d,J=8.9)
   Ⅰa-349 112-113℃,1H-NMR(CDCl3)δ3.12(3H,s),3.88(3H,s),5.16(2H,s),6.99(2H,d,J=9.2),7.12(1H,dJ=8.8),7.33-7.48(5H,m),7.73(1H,dd J=8.3,1.8),7.74(1H,s),7.87(1H,s),8.04(2H,d,J=9.2)
   Ⅰa-350 137-138℃,1H-NMR(CDCl3)δ1.75(3H,s),1.81(3H,s),3.87(3H,s),4.60(2H,d,J=6.8),5.49(1H,t,J=6.8),5.70(1H,s),6.91(1H,d,J=9.2),6.98(2H,d,J=9.1),7.32-7.35(2H,m),7.82(1H,s),8.04(2H,d,J=9.1)
   Ⅰa-351 127-128℃,1H-NMR(CDCl3)δ1.75(3H,s),1.81(3H,s),3.23(3H,s),3.873H,s),4.63(2H,d,J=6.8),5.48(1H,t,J=6.8),6.98(2H,d,J=9.1),7.051H,d,J=9.1),7.71-7.75(2H,m),7.85(1H,s),8.04(2H,d,J=9.1)
   Ⅰa-352 99-100℃,1H-NMR(CDCl3)δ2.58(3H,s),3.83(3H,s),5.17(2H,s),5.71(1H,s),6.93-7.01(3H,m),7.23(1H,d,J=1.9),7.32(1H,d,J=1.9),7.34-7.44(5H,m),8.01(2H,d,J=9.1)
   Ⅰa-353 159-160℃,1H-NMR(CDCl3)δ2.57(3H,s),3.11(3H,s),3.86(3H,s),5.17(2H,s),6.97(2H,d,J=9.1),7.13(1H,d,J=8.5),7.35-7.47(5H,m),7.65(2H,d,J=9.1)7.99(2H,d,J=9.1)
   Ⅰa-354 oil,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.16(3H,s),2.57(3H,s),3.86(3H,s),4.61(2H,d,J=6.7),5.50(1H,brt,J=6.7),5.71(1H,s),6.94(2H,d,J=7.3),6.97(1H,d,J=8.6),7.23(1H,dd,J=8.6,1.8),7.28(1H,d,J=1.8),8.00(2H,d,J=7.3)
   Ⅰa-355 130-131℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.57(3H,s),3.213H,s),3.87(3H,s),4.63(2H,d,J=6.7),5.49(1H,t,J=6.7),6.97(2H,d,J=6.7),7.07(1H,d,J=9.1)7.62-7.67(2H,m),7.99(2Hh,d,J=9.1)
Ⅰa-356 mp91.5-92.5℃；1H NMR(CDCl3)δ1.74(s,3H),1.76(s,3H),1.77(s,3H),1.80(s,3H),2.34(s,3H),2.54(s,3H),3.74(d,J=6.6Hz,2H),4.63(d,J=6.6Hz,2H),5.37(brt,J=6.6Hz,1H),5.54(brt,J=6.6Hz,1H),6.68(d,J=8.5Hz,2H),7.04(t,J=8.5Hz,1H),7.19(d,J=8.5Hz,2H),7.27(brd,J=8.5Hz,1H),7.33(dd,J=2.0,12.0Hz,1H)7.39(s,1H)
Ⅰa-357 mp136-136.5℃；1H NMR(CDCl3)δ1.73(s,3H),1.76(s,3H),1.77(s,3H),1.82(s,3H),2.37(s,3H),2.52(s,3H),3.74(d,J=6.6Hz,2H),4.64(d,J=6.8Hz,2H),5.35(brt,J=6.6Hz,1H),5.55(brt,J=6.8Hz,1H),6.68(d,J=8.8Hz,2H),7.01-7.12(m,3H),7.35(s,1H),7.43(d,J=8.8Hz,2H)
                             表103
   Ⅰb-3 157-158℃,(CDCl3)δ1.78(3H,s),1.82(3H,s),3.56(3H,s),3.80(3H,s),4.62(2H,d,J=6.8),5.52(1H,t,J=6.8),5.69(1H,s),5.84(1H,s),6.95(4H,d,J=2.4),7.05(1H,s),7.76(1H,td,J=7.8,1.8),7.94(1H,d,J=7.8),8.75(1H,dd,J=4.9,2.4)
   Ⅰb-8 oil,1H-NMR(CDCl3)δ1.76(3H,s),1.79(3H,s),2.29(3H,s),2.37(3H,s),3.89(3H,s),4.64(2H,d,J=6.7),5.57(1H,brt,J=6.7),6.85-6.96(3H,m),7.16(1H,s),7.22-7.27(1H,m),7.33(1H,s),7.46(1H,d,J=7.9),7.75(1H,dt,J=1.8,7.9),8.71(1H,dd,J=4.9,1.8),
  Ⅰb-11 112-113℃,1H-NMR(CDCl3)δ1.45(3H,s),1.73(3H,s),1.76(3H,s),1.81(3H,s),2.67(3H,s),3.25(3H,s),3.68(3H,s),3.85(3H,s),4.39(2H,d,J=7.3),4.64(2H,d,J=6.3),5.27(1H,t,J=7.3),5.49(1H,t,J=6.8),7.09(1H,d,J=8.5),7.33-7.39(2H,m),7.49(1H,s),7.60(1H,dd,J=8.5,2.5),8.16(1H,d,J=8.5),8.56(1H,d,J=1.8)
  Ⅰb-12 139-141℃,1H-NMR(CDCl3)δ2.66(3H,s),3.12(3H,s),3.64(3H,s),3.82(3H,s),3.84(2H,brs),5.18(2H,s),7.05(1H,dd,J=8.5,3.0),7.14(1H,d,J=8.5),7.32-7.48(8H,m),7.86(1H,d,J=8.5),8.21(1H,d,J=3.0)
  Ⅰb-13 oil,1H-NMR(CDCl3)δ1.76(3H,s),1.79(3H,s),2.28(3H,s),2.36(3H,s),3.73(2H,brs),3.88(3H,s),4.63(2H,d,J=6.8),5.57(1H,brt,J=6.8),6.84-6.95(3H,m),7.06(1H,dd,J=2.9,8.3),7.14(1H,s),7.25(1H,dd,J=0.5,8.3),8.20(1H,dd,J=0.5,2.9)
  Ⅰb-15 157-158℃,1H-NMR(CDCl3)δ2.30(3H,s),2.35(3H,s),2.99(6H,s),3.70(2H,brs),6.79(2H,d,J=8.9),7.05(1H,dd,J=8.5,2.4),7.13(1H,s),7.24-7.29(4H,m),8.20(1H,d,J=2.4)
  Ⅰb-16 164-165℃,1H-NMR(CDCl3)δ1.75(3H,s),1.78(3H,s),1.81(3H,s),3.56(3H,s),3.77(2H,d,J=6.8),3.79(3H,s),4.61(2H,d,J=7.3),5.34(1H,t,J=6.8),5.53(1H,t,J=7.3),5.68(1H,s),5.85(1H,s),6.92-6.98(4H,m),7.05(1H,s),7.77(1H,d,J=9.2),8.14(1H,d,J=3.1)
  Ⅰb-17 oil,1H-NMR(CDCl3)δ1.75(6H,s),1.78(3H,s),1.79(3H,s),2.29(3H,s),2.37(3H,s),3.76(2H,d,J=6.6),3.88(3H,s),4.63(2H,d,J=6.8),5.35(1H,brt,J=6.6),5.57(1H,brt,J=6.8),6.84-6.98(4H,m),7.13(1H,s),7.27(1H,d,J=8.6),7.31(1H,s),8.13(1H,d,J=2.4)
  Ⅰb-20 116-117℃,1H-NMR(CDCl3)δ1.75(3H,s)1.78(3H,s),2.30(3H,s)2.36(3H,s),2.99(6H,s),3.75(2H,d,J=6.8),5.35(2H,t,J=6.8),6.90(2H,d,J=8.5),6.94(1H,dd,J=8.5,3.1),7.13(1H,s),7.22-7.29(4H,m),8.13(1H,d,J=2.4)
  Ⅰb-21 233-234℃,1H-NMR(CDCl3)δ2.65(3H,s),3.13(3H,s),3.69(3H,s),3.84(3H,s),5.19(2H,s),7.15(1H,d,J=8.5),7.33-7.48(8H,m),8.10(1H,brs),8.16(2H,d,J=1.4),8.88(1H,s)
  Ⅰb-23 152-153℃,1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.30(3H,s),2.37(3H,s),3.88(3H,s),4.63(2H,d,J=6.6),5.56(1H,brt,J=6.6),6.84-6.96(3H,m),7.17(1H,s),7.32(1H,s),7.53(1H,d,J=8.5),8.25(1H,dd,J=2.7,8.5),8.76(1H,d,J=2.7)
  Ⅰb-25 178-180℃,1H-NMR(CDCl3)δ2.32(3H,s),2.37(3H,s),3.00(6H,s),6.80(2H,d,J=9.1),7.17(1H,s),7.25(2H,d,J=8.5),7.32(1H,s),7.53(1H,d,J=8.5),8.05(1H,brs),8.24(1H,dd,J=8.5,2.5),8.74(1H,d,J=2.5)
  Ⅰb-35 219-221℃,1H-NMR(CDCl3)δ3.00(6H,s),3.09(3H,s),3 84(3H,s),3.863H,s),6.50(1H,br),6.80(2H,d,J=9.0),6.99(1H,s),7.51(2H,d,J=9.0),7.52(1H,s),7.71(1H,dd,J=2.7,8.7),8.02(1H,d,J=8.7),8.52(1H,d,J=2.7)
                        表104
Ⅰb-37 187-190℃,1H-NMR(CDCl3)δ2.32(3H,s),2.36(3H,s),3.00(6H,s),3.10(3H,s),6.66(1H,brs),6.80(2H,d,J=9.2),7.16(1H,s),7.18-7.32(3H,m),7.48(1H,d,J=8.5),7.76(1H,dd,J=8.5,3.1),8.51(1H,d,J=3.1)
Ⅰb-39 169-170℃,1H-NMR(CDCl3)δ2.67(3H,s),3.06(6H,s),3.13(3H,s),3.65(3H,s),3.83(3H,s),5.18(2H,s),7.04(1H,dd,J=8.5,3.0),7.13(1H,d,J=8.5),7.32-7.47(8H,m),7.93(1H,d,J=8.5),8.25(1H,d,J=3.0)
Ⅰb-40 205-206℃,1H-NMR(CDCl3)δ1.73(3H,s),1.81(3H,s),3.06(6H,s),3.59(3H,s),3.80(3H,s),4.61(2H,d,J=6.8),5.51(1H,t,J=6.8),5.70(1H,brs),5.87(1H,brs),6.92(3H,s),7.04-7.10(2H,m),7.82(1H,d,J=8.5),8.24(1H,d,J=1.8)
Ⅰb-41 157-158℃,1H-NMR(CDCl3)δ1.74(3H,s),1.81(3H,s),2.70(3H,s),3.05(6H,s),3.21(3H,s),3.61(3H,s),3.81(3H,s),4.61(2H,d,J=6.8),5.51(1H,t,J=6.8),7.03-7.11(2H,m),7.33(1H,dd,J=8.5,2.0),7.38(1H,d,J=2.0),7.41(1H,s),7.92(1H,d,J=8.5),8.24(1H,d,J=2.0)
Ⅰb-44 117-118℃,1H-NMR(CDCl3)δ1.76(3H,s),1.80(3H,s),2.29(3H,s),2.36(3H,s),3.04(6H,s),3.89(3H,s),4.63(2H,d,J=6.8),5.57(1H,brt,J=6.8),6.86-6.95(3H,m),7.08(1H,dd,J=2.9,8.6),7.14(1H,s),7.31(1H,s),7.32(1H,d,J=8.6),8.22(1H,d,J=2.9)
Ⅰb-46 216-218℃,1H-NMR(CDCl3)δ3.64(3H,s),3.82(3H,s),5.16(2H,s),5.73(1H,s),5.77(1H,s),6.94(1H,dd,J=8.5,2.4),7.07(1H,s),7.09(2H,d,J=6.7),7.36-7.47(5H,m),8.25(1H,d,J=8.5),8.54(1H,dd,J=8.5,2.4),9.54(1H,d,J=2.4)
Ⅰb-47 159-160℃,1H-NMR(CDCl3)δ2.63(3H,s),3.14(3H,s),3.73(3H,s),3.86(3H,s),5.19(2H,s),7.16(2H,d,J=8.5),7.29-7.48(6H,m),7.56(1H,s),8.35(1H,d,J=9.1),8.54(1H,dd,J=9.1,2.5),9.54(1H,d,J=2.5)
Ⅰb-49 194-195℃,1H-NMR(CDCl3)δ2.35(3H,s),2.41(3H,s),3.01(6H,s),6.80(2H,d,J=9.1),7.20(1H,s),7.26(2H,d,J=9.1),7.37(1H,s),7.67(1H,d,J=9.1),8.53(1H,dd,J=9.1,2.5),9.53(1H,d,J=2.4)
Ⅰb-51 126-127℃,1H-NMR(CDCl3)δ2.25(3H,s),2.32(3H,s),3.01(6H,s),6.80(2H,d,J=8.5),7.09(1H,s),7.18(1H,s),7.22-7.29(2H,m),7.38(1H,d,J=8.5),7.66(1H,dd,J=8.0,2.4),8.76(1H,d,J=2.4)
Ⅰb-54 162-163℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),3.48(3H,s),3.76(3H,s),4.62(2H,d,J=6.8),5.53(1H,t,J=6.8),5.72(1H,s),5.81(1H,s),6.47(1H,s),6.94-6.99(2H,m),7.04(1H,s),7.37-7.68(4H,m),7.99(1H,dd,J=6.1,1.8)8.62(1H,d,J=4.9),8.89(1H,d,J=1.8),
Ⅰb-58 油，1H-NMR(CDCl3)δ1.76(3H,s),1.80(3H,s),2.28(3H.s),2.30(3H,s),3.89(3H,s),4.64(2H,d,J=6.7),5.57(1H,brt,J=6.7),6.86-6.96(3H,m),7.13(1H,s),7.19(1H,s),7.36(1H,dd,J=8.2,4.9),7.70(1H,dt,J=1.8,8.2),8.60(1H,dd,J=4.9,1.8),8.65(1H,d,J=1.8)
Ⅰb-65 180-181℃,1H-NMR(CDCl3)δ2.28(3H,s),2.31(3H,s),3.00(6H,s),4.45(2H,brs),6.57(1H,d,J=9.1),6.80(2H,d,J=9.1),7.09(1H,s),7.15(1H,s),7.25(2H,dd,J=8.0,2.4),7.47(1H,dd,J=8.5,2.4),8.10(1H,d,J=2.4)
Ⅰb-67 185-188℃1H-NMR(CDCl3)δ2.07(3H,s),2.21(3H,s),2.28(3H,s),3.00(6H,s),4.41(2H,brs),6.41(1H,d,J=7.8),6.80(2H,d,J=9.2),6.97(1H,s),7.12(1H,s),7.22-7.29(3H,m)
                           表105
Ⅰb-69 mp184-185.5℃；1H NMR(CDCl3)δ1.75(s,3H),1.77(s,3H),2.29(s,3H),2.30(s,3H),3.00(s,6H),3.90(brt,J=5.6Hz,2H),4.45(brs,1H),5.37(brt,J=5.6Hz,1H),6.45(dd,J=0.5,8.5Hz,1H),6.80(d,J=8.8Hz,2H,7.10(s,1H),7.15(s,1H),7.27(d,J=8.8Hz,2H),7.47(dd,J=2.4,8.5Hz,1H),8.13(dd,J=0.5,2.4Hz,1H)
Ⅰb-71 118-119℃,1H-NMR(CDCl3)δ1.73(3H,s),1.76(3H,s),2.08(3H,s),2.20(3H,s),2.28(3H,s),3.00(6H,s),3.83(2H,d,J=6.8),4.81(1H,brs),5.35(1H,t,J=6.7),6.29(1H,d,J=8.5),6.79(2H,d,J=8.5),6.97(1H,s),7.12(1H,s),7.24-7.29(3H,m)
Ⅰb-73 196-197℃,1H-NMR(CDCl3)δ2.25(3H,s),2.27(3H,s),2.32(3H,s),3.02(6H,s),6.86(2H,d,J=8.5),7.11(1H,s),7.17(1H,s),7.28(2H,d,J=8.5),7.75(1H,dd,J=8.0,2.4),8.19(1H,brs),8.25-8.28(2H,m)
Ⅰb-75 169-171℃,1H-NMR(CDCl3)δ2.05(3H,s),2.22(3H,s),2.27(3H,s),2.29(3H,s),3.01(6H,s),6.80(2H,d,J=8.5),6.97(1H,s),7.14(1H,s),7.28(1H,d,J=8.5),7.49(1H,d,J=8.5),7.92(1H,brs),8.05(1H,d,J=8.5)
Ⅰb-79 149-152℃,1H-NMR(CDCl3)δ2.07(3H,s),2.28(3H,s),2.29(3H,s),3.00(6H,s),3.19(3H,s),6.80(2H,d,J=9.1),6.94(1H,s),7.03(1H,d,J=8.5),7.15(1H,s),7.24-7.27(2H,m),7.47(1H,d,J=8.5)
Ⅰb-81 164-165℃,1H-NMR(CDCl3)δ2.69(3H,s),3.12(3H,s),3.16(6H,s),3.59(3H,s),3.77(3H,s),5.18(2H,s),6.59(1H,d,J=8.5),6.84(1H,s),7.14(1H,d,J=8.5),7.32-7.48(7H,m),7.84(1H,dd,J=8.5,2.4),8.40(1H,d,J=2.4)
Ⅰb-82 72-74℃,1H-NMR(CDCl3)δ1.75(3H,s),1.82(3H,s),3.16(6H,s),3.52(3H,s),3.74(3H,s),4.62(2H,d,J=6.8),5.52(1H,t,J=6.8),5.68(1H,s),5.85(1H,s),6.45(1H,s),6.61(1H,d,J=9.1),6.94(2H,d,J=1.8),7.05(1H,d,J=1.2),7.81(1H,dd,J=8.5,2.4)8.46(1H,d,J=2.4),
Ⅰb-83 132-133℃,1H-NMR(CDCl3)δ1.75(3H,s),1.81(3H,s),2.71(3H,s),3.15(6H,s),3.25(3H,s),3.61(3H,s),3.77(3H,s),4.62(2H,d,J=6.8),5.52(1H,t,J=6.8),6.59(1H,d,J=8.5),6.83(1H,s),7.07(1H,d,J=8.5),7.34(1H,dd,J=8.5,1.8),7.38(1H,d,J=1.8),7.83(1H,dd,J=6.1,1.2),8.39(1H,d,J=1.2)
Ⅰb-90 91-91.5℃,1H-NMR(CDCl3)δ1.79(3H,s),1.82(3H,s),2.27(3H,s),2.313H,s),3.00(6H,s),4.87(2H,d,J=7.1),5.57(1H,brt,J=7.1),6.79-6.83(3H,m),7.10(1H,s),7.16(1H,s),7.27(2H,d,J=8.8),7.59(1H,dd,J=2.4,8.3),8.17(1H,dd,J=0.7,2.4)
Ⅰb-99 239-241℃,1H-NMR(CDCl3)δ2.28(3H,s),2.34(3H,s),3.02(6H,s),3.30(3H,s),6.81(2H,d,J=8.8),7.26(2H,d,J=8.8),7.95(1H,dd,J=2.2,8.0),8.15(1H,dd,J=0.7,8.0),8.75(1H,dd,J=0.7,2.2)
Ⅰb-101 159-160℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),3.50(3H,s),3.76(3H,s),4.62(2H,d,J=6.8),5.53(1H,t,J=6.8),5.73(1H,s),5.84(1H,s),6.48(1H,s),6.91-6.99(2H,m),7.04(1H,d,J=1.8),7.59(2H,d,J=5.5),8.70(2H,d,J=5.5),
Ⅰb-105 113-114℃,2.28(3H,s),2.29(3H,s),3.91(3H,s),5.21(2H,s),6.83(1H,dd,J=2.0,8.3),6.90(1H,d,J=2.0),6.95(1H,d,J=8.3),7.12(1H,s),7.17(1H,s),7.30(2H,d,J=6.1),7.31-7.50(5H,m),8.65(2H,d,J=6.1)
Ⅰb-124 157-158℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),3.66(3H,s),3.80(3H,s),4.05(3H,s),4.62(2H,d,J=6.8),5.52(1H,t,J=6.8),5.72(1H,s),5.78(1H,s),6.89-6.98(2H,m),7.03(1H,d,J=1.8)7.09(1H,s),7.45(1H,d,J=1.2)8.89(1H,d,J=1.2)
                          表106
 Ⅰb-127 99-100℃,1H-NMR(CDCl3)δ2.32(3H,s),2.40(3H,s),3.03(6H,s),4.04(3H,s),6.79(2H,d,J=8.7),6.87(1H,s),7.16(1H,s),7.25(2H,d,J=7.3),7.34(1H,s),8.86(1H,d,J=1.2)
 Ⅰb-145 184-185℃,1H-NMR(CDCl3)δ2.60(3H,s),3.14(3H,s),3.71(3H,s),3.84(3H,s),5.19(2H,s),7.16(1H,d,J=7.9),7.33(7H,m),7.58(1H,d,J=8.6),7.59(1H,s),8.24(1H,d,J=9.2)
 Ⅰb-146 154-155℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),3.62(3H,s),3.80(3H,s),4.62(2H,d,J=6.8),5.53(1H,t,J=6.8),5.69(1H,s),5.76(1H,s),6.89-7.03(3H,m),7.12(1H,s),7.57(1H,d,J=8.5)8.14(1H.d,J=9.2)
 Ⅰb-147 195-196℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.64(3H,s),3.26(3H,s),3.71(3H,s),3.84(3H,s),4.64(2H,d,J=6.8),5.49(1H,t,J=6.8),7.10(1H,d,J=8.6),7.34(1H,dd,J=8.5,1.8),7.39(1H,d,J=1.8)7.59(1H,s),7.58(1H,d,J=9.2),8.23(1H,d,J=9.2)
 Ⅰb-150 197-198℃,1H-NMR(CDCl3)δ2.34(3H,s),2.39(3H,s)3.01(6H,s),6.81(2H,d,J=9.1),7.21(1H,s),7.26(2H,d,J=8.5),7.34(1H,s),7.58(2H,d,J=4.2)
 Ⅰb-154 185-186℃,1H-NMR(CDCl3)δ2.61(3H,s),3.14(3H,s),3.25(6H,s),3.67(3H,s),3.81(3H,s),5.19(2H,s),6.85(1H,d,J=9.7),7.14(1H,d,J=8.8),7.33-7.48(7H,m),7.65(1H,s),8.02(1H,d,J=9.7)
 Ⅰb-162 188-189℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),3.60(3H,s),3.79(3H,s),4.21(3H,s),4.62(2H,d,J=6.8),5.52(1H,t,J=6.8),5.69(1H,s),5.72(1H,s),6.91-7.07(4H,m),7.13(1H,s),8.06(1H,d,J=9.8)
 Ⅰb-165 152-153℃,1H-NMR(CDCl3)δ2.33(3H,s),2.39(3H,s),3.01(6H,s),4.19(3H,s),6.80(2H,d,J=9.1),7.03(1H,d,J=9.1),7.19(1H,s),7.26(2H,d,J=7.8),7.33(1H,s),7.53(1H,d,J=9.1)
 Ⅰb-168 oil,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),3.65(3H,s),3.81(3H,s),4.63(2H,d,J=6.7),5.53(1H,brt,J=6.7),5.74(1H,s),5.77(1H,s),6.92-6.99(3H,m),7.04(1H,d,J=1.8),8.53(1H,d,J=1.8),8.69(1H,s),9.25(1H,s)
 Ⅰb-169 165-166℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.72(3H,s),3.24(3H,s),3.77(3H,s),3.84(3H,s),4.64(2H,d,J=6.8),5.49(1H,t,J=6.8),7.10(1H,d,J=8.5),7.35(1H,dd,J=8.5,2.4),7.41(1H,d,J=2.4),7.45(1H,s),8.57(1H,s),8.69(1H,s),9.32(1H,s)
 Ⅰb-188 165-168℃,1H-NMR(CDCl3)δ2.29(3H,s),2.42(3H,s),3.00(6H,s),4.46(2H,brs),5.31(1H,s),6.78(2H,d,J=8.5),7.11(1H,s),7.23(2H,d,J=8.5),7.38(1H,s),
 Ⅰb-198 103-104℃,1H-NMR(CDCl3)δ2.28(3H,s),2.43(3H,s),2.99(6H,s),3.50(2H,brs),3.74(3H,s),5.76(1H,s),6.79(2H,d,J=8.5),7.09(1H,s),7.24(2H,d,J=8.5),7.43(1H,s)
 Ⅰb-200 oil,1H-NMR(CDCl3)δ1.73(3H,s),1.76(3H,s),2.29(3H,s),2.46(3H,s),2.99(6H,s),3.16(1H,brs),3.68(3H,s),3.70(2H,d,J=5.5),5.37(1H,brt,J=5.5),5.67(1H,s),6.79(2H,d,J=9.2),7.10(1H,s),7.24(2H,d,J=9.2),7.44(1H,s)
 Ⅰb-202 174-177℃1H-NMR(CDCl3)δ2.31(3H,s),2.43(3H,s),3.01(6H,s),3.12(3H,s),3.93(3H,s),6.25(1H,brs),6.37(1H,s),6.79(2H,d,J=8.5),7.10(1H,s),7.25(2H,d,J=8.5),7.42(1H,s),
 Ⅰb-203 234-235℃,1H-NMR(CDCl3)δ3.89(3H,s),3.95(3H,s),5.17(2H,s),5.56(1H,brs),5.74(1H,brs),6.92(1H,dd,J=8.2,2.0),7.05-7.07(2H,m),7.39-7.53(7H,m),7.58(1H,s),7.95(1H,d,J=8.0),8.11(1H,d,J=8.3),
                          表107
 Ⅰb-204 197-198℃,1H-NMR(CDCl3)δ2.68(3H,s),3.14(3H,s),3.93(3H,s),4.05(3H,s),5.20(2H,s),7.16(1H,d,J=7.3),7.37-7.53(9H,m),7.96(1H,d,J=7.3),8.06(1H,s),8.11(1H,d,J=8.0)
 Ⅰb-205 189-190℃,1H-NMR(CDCl3)δ1.77(3H,s),1.83(3H,s),3.89(3H,s),3.95(3H,s),4.63(2H,d,J=6.8),5.53(1H,t,J=6.8),5.55(1H,s),5.76(1H,s),6.89-7.03(3H,m),7.41(1H,td,J=7,3,1.2),7.52(1H,td,J=7.3,1.2),7.58(1H,s),7.95(1H,d,J=7.3),8.11(1H,d,J=7.3)
 Ⅰb-206 166-167℃,1H-NMR(CDCl3)δ1.77(3H,s),1.81(3H,s),2.72(3H,s),3.25(8H,s),3.93(3H,s),4.05(3H,s),4.65(2H,d,J=6.8),5.49(1H,t,J=6.8),7.10(1H,d,J=8.5),7.36-7.53(4H,m),7.96(1H,d,J=7.3),8.05(1H,s),8.11(1H,d,J=8.5)
Ⅰb-207 mp75-78℃；1H NMR(CDCl3)δ1.75(s,3H),1.76(s,3H),1.77(s,3H),1.81(s,3H),2.27(s,3H),2.36(s,3H),3.75(d,J=6.6Hz,2H),4.63(d,J=6.6Hz,2H),5.33-5.36(m,1H),5.52-5.57(m,1H),6.93-7.11(m,5H),7.24-7.30(m,2H),8.12(d,J=2.4Hz,1H)IR(KBr):3405,2970,2924,1596,1570,1521,1493,1466,1386,1363,1299,1282,1235,1196,1126,1079,964cm-1
Ⅰb-208 mp100-102℃；1H NMR(CDCl3)δ1.76(s,3H),1.81(s,3H),2.27(s,3H),2.34(s,3H),3.73(brs,3H),4.63(d,J=6.6Hz,2H),5.53-5.58(m,1H),7.00-7.11(m,5H),7.23-7.29(m,2H),8.20(d,J=2.4Hz,1H)IR(KBr):3422,3326,3202,2973,2923,1618,1563,1517,1484,1383,1309,1298,1267,1256,1230,1125,1000cm-1
Ⅰb-209 mp107-108℃；1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.31(s,3H),2.40(s,3H),4.64(d,J=6.6Hz,2H),5.52-5.58(m,1H),7.02-7.11(m,3H),7.18(s,1H),7.37(s,1H),7.66(d,J=8.7Hz,1H),8.54(dd,J=2.4,8.4Hz,1H),9.53(d,J=2.1Hz,1H)IR(KBr):3440,2969,1592,1572,1517,1497,1460,1346,1314,1294,1264,1233,1195,1128,990cm-1
Ⅰb-210 油；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.36(s,3H),4.56(d,J=6.6Hz,2H),5.54(t,J=6.6Hz,1H),6.97(d,J=8.1Hz,2H),7.15(s,1H),7.25(m,1H),7.28(d,J=8.1Hz,2H),7.32(s,1H),7.45(d,J=7.5Hz,1H),7.75(td,J=7.5,1.8Hz,1H),8.71(d,J=5.1Hz,1H).
Ⅰb-211 mp91-92℃；1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.29(s,3H),2.36(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.98-7.15(m,4H),7.25(m,1H),7.32(s,1H),7.45(m,1H)7.75(m,1H),8.71(m,1H)；IR(KBr)1584,1566,1520,1498,1469,1460,1433,1422,1385,1302,1278,1267,1234,1129,998cm-1.
Ⅰb-212 mp120-122℃；1H NMR(CDCl3)δ1.13-1.25(m,4H),1.62-1.90(m,4H),1.77(s,3H),1.81(s,3H),2.03-2.16(m,2H),2.27(s,3H),2.36(s,3H),3.31(m,1H),4.63(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.90-7.13(m,5H),7.21-7.32(m,2H),8.10(m,1H)；IR(KBr)3392,1591,1516,1482,1298,1274,1262,1231,1136,1124,994,835cm-1.
Ⅰb-213 1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.16(s,6H),2.27(s,3H),3.85(s,3H),4.63(d,J=6.6Hz,2H),5.53-5.58(m,1H),6.98-7.13(m,4H),7.22-7.30(m,3H),8.31(t,J=3.0Hz,1H),；IR(neat):2960,2918,1579,1496,1294,1117,991.753cm-1
Ⅰb-214 1H NMR(CDCl3)δ1.69(s,3H),1.74(s,3H),1.77(s,3H),1.81(s,3H),2.17(s,3H),2.26(s,3H),4.56(d,J=6.6Hz,2H),4.63(d,J=6.9Hz,2H),5.34-5.39(m,1H),5.53-5.58(m,1H),7.97-7.13(m,4H),7.21-7.29(m,3H),8.30(dd,J=1.5,4.5Hz,1H),；IR(neat):2968,2914,1577,1516,1495,1267,1229,1117.995,841,782cm-1
                             表108
Ⅰb-215 mp134-136℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.93(s,6H)；1.94(s,6H)；3.78(brs,2H)；4.64(d,J=6.6Hz,2H)；5.57(m,1H)；6.73-7.13(m,5H)；8.24(m,1H)；IR(KBr):3465,3333,3216,2920,1633,1512,1493,1461,1296,1262,1242,1209,1115cm-1.
Ⅰb-216 mp124-126℃；1H NMR(CDCl3)δ1.76(s,3H)；1.77(s,3H)；1.79(s,3H)；1.82(d,3H)；1.93(s,6H)；1.95(s,6H)；3.74(br,1H)；3.77(d,J=6.3Hz,2H)；4.64(d,J=6.9Hz,2H)；5.38(m,1H)；5.57(m,1H)；6.73-7.10(m,5H)；8.14(d,J=2.7Hz,1H)；IR(KBr):3272,2913,1596,1509,1466,1302,1261,1240,1209,1115cm-1.
Ⅰb-217 mp103-110℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.91(s,6H)；1.93(s,6H)；4.64(d,J=6.6Hz,2H)；5.57(m,1H)；6.74-7.23(m,5H)；8.28(d,J=2.7Hz,1H)；IR(KBr):3441,2921,1570,1514,1462,1298,1264,1241,1210,1113,1004cm-1.
Ⅰb-218 mp109-110℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),3.77(s,3H),3.78(s,3H),4.87(d,J=7.2Hz,2H),5.57(m,1H),6.45-6.55(m,2H),6.81(d,J=8.7,Hz,1H),6.83(s,1H),6.91(s,1H),7.19(t,J=8.1Hz,1H),7.83(dd,J=8.7,2.4Hz,1H),8.37(d,J=2.4Hz,1H)IR(KBr):3425,3348,3223,1634,1604,1524,1484,1463,1443,1396,1359,1279,1209,1053,1032,1003,867,832,782,661cm-1
Ⅰb-219 mp99-100℃；1H NMR(CDCl3)δ1.25(d,J=6.3Hz,6H),1.78(s,3H),1.81(s,3H),3.63(m,1H),3.77(s,3H),3.79(s,3H),4.87(d,J=6.9Hz,2H),5.57(m,1H),6.33-6.47(m,2H),6.81(d,J=8.7Hz,1H),6.92(s,2H),7.20(t,J=8.4Hz,1H),7.83(dd,J=8.7,2.4Hz,1H),8.36(d,J=2.4Hz,1H).IR(KBr):3408,1627,1599,1526,1502,1477,1280,1246,1210,1182,1133,1121,1054,1030,968,869,837,783,668cm-1
Ⅰb-220 mp139-145℃；1H NMR(CDCl3)δ1.25(d,J=6.6Hz,6H),1.79(s,3H),1.82(s,3H),3.79(s,3H),3.80(s,3H),4.53(m,1H),4.61(s,2H),4.88(d,J=6.9Hz,2H),5.57(m,1H),6.82(d,J=9.0,Hz,1H),6.93(s,1H),6.96(s,1H),7.14-7.24(m,2H),7.45(m,1H),7.84(dd,J=9.0,2.1Hz,1H),8.37(d,J=2.1Hz,1H).IR(KBr):3377,3273,1656,1605,1564,1520,1484,1465,1394,1339,1282,1207,1055,1033,1008,984,871,829,779,688,653,602,541cm-1
Ⅰb-221 mp137-138℃；1H NMR(CDCl3)δ1.24(d,J=6.9Hz,6H),1.79(s,3H),1.82(s,3H),2.78(d,J=5.4Hz,3H),3.79(s,3H),3.81(s,3H),4.17(q,J=5.4Hz,2H),4.44(m,1H),4.88(d,J=7.2Hz,2H),5.57(m,1H),6.82(d,J=8.7Hz,1H),6.93(s,1H),6.96(s,1H),7.12-7.22(m,2H),7.44(t,J=8.1mz,1H),7.84(dd,J=8.7,2.7Hz,1H),8.38(d,J=2.7Hz,1H)IR(KBr):3294,1604,1566,1519,1484,1464,1395,1334,1281,1208,1187,1153,1103,1055,1035,1007,981,870,829,779,688cm-1
Ⅰb-222 mp79-80℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),1.78(s,3H),1.81(s,3H),3.71(d,J=6.6Hz,2H),3.77(s,3H),3.79(s,3H),4.87(d,J=8.4Hz,2H),5.35(m,1H),5.57(m,1H),6.36-6.48(m,2H),6.81(d,J=8.4,Hz,1H),6.92(s,2H),7.21(t,J=8.4Hz,1H),7.83(dd,J=8.4,2.4Hz,1H),8.37(d,J=2.4Hz,1H)IR(KBr):3416,1629,1603,1570,1526,1464,1395,1278,1209,1051.1034,1006,869,830,777,666cm-1
                          表109
Ⅰb-223 mp103-104℃；1H NMR(CDCl3)δ1.56(s,3H),1.72(s,3H),1.78(s,3H),1.82(s,3H),2.79(d,J=5.1Hz,3H),3.78(s,3H),3.79(s,3H),4.22(q,J=5.1Hz,1H),4.28(d,J=6.9Hz,2h),4.88(d,J=6.6Hz,2H),5.30(m,1H),5.57(m,1H),6.82(d,J=8.1Hz,1H),6.91(s,2H),6.95(s,1H),7.17-7.26(m,2H),7.37-7.44(m,1H),7.83(dd,J=8.1,2.4Hz,1H),8.37(d,J=2.4Hz,1H)IR(KBr):3404,3313,1604,1566,1520,1484,1465,1395,1335,1282,1209,1153,1127,1055,1034,867,828,669cm-1
Ⅰb-224 mp95-96℃；1H NMR(CDCl3)δ1.70(s,3H),1.82(s,3H),2.27(s,3H),3.82(br,2H),4.87(d,J=7.2Hz,2H),5.57(m,1H),6.64-6.55(m,2H),6.81(d,J=8.4,Hz,1H),7.50(t,J=8.1Hz,1H),7.11(s,1H),7.12(s,1H),7.59(dd,J=8.4,2.4Hz,1H),8.17(d,J=2.4Hz,1H)IR(KBr)；3436,3328,3218,1634,1622,1606,1566,1522,1480,1460,1444,1396,1362,1304,1285,1245,1168,1129,1008,834cm-1
Ⅰb-225 mp90-91℃；1H NMR(CDCl3)δ1.26(d,J=6.3Hz,2H),1.79(s,3H),1.82(s,3H),2.22(s,3H),2.26(s,3H),3.64(m,1H),4.87(d,J=7.5Hz,2H),5.57(m,1H),6.33-6.47(m,2H),6.81(d,J=8.4,Hz,1H),7.05(t,J=8.1Hz,1H),7.10(s,1H),7.13(s,1H),7.59(dd,J=8.4,2.4Hz,1H),8.17(d,J=2.4Hz,1H)IR(KBr):3335,1628,1606,1527,1481,1283,1240,1183,1116,989,835,812,635cm-1
Ⅰb-226 mp87-88℃；1H NMR(CDCl3)δ0.91-1.09(m,2H),1.13-1.36(m,4H),1.40-1.92(m,5H),1.79(s,3H),1.82(s,3H),2.22(s,3H),2.26(s,3H),2.98(d,J=6.6Hz,2H),4.87(d,J=7.2Hz,2H),5.57(m,1H),6.32-6.46(m,2H),6.80(d,J=8.4Hz,1H),7.04(t,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.59(dd,J=8.4,2.4Hz,1H),8.17(d,J=2.4Hz,1H)IR(KBr):3444,1628,1603,1573,1524,1481,1459,1358,1278,1242,1168,1117,1006,974,825cm-1.
Ⅰb-227 mp76-77℃；1H NMR(CDCl3)δ1.55(s,3H),1.71(s,3H),1.79(s,3H),1.82(s,3H),2.19(s,3H),2.28(s,3H),2.80(d,J=5.4Hz,3H),4.20(q,J=5.4Hz,1H),4.27(d,J=7.2Hz,2H),4.87(d,J=7.2Hz,2H),5.29(m,1H),5.57(m,1H),6.82(d,J=8.1Hz,1H),7.13(s,2H),7.16-7.31(m,3H),7.59(dd,J=8.1,2.4Hz,1H),8.17(d,J=2.4Hz,1H)IR(KBr):3314,1605,1562,1514,1481,1346,1328,1307,1283,1154,1125,1072,1003,854,831,703,666,cm-1
Ⅰb-228 泡沫；1H NMR(CDCl3)δ1.00-1.74(m,11H),1.79(s,3H),1.82(s,3H),2.13(s,3H),2.27(s,3H),2.98(d,J=6.6Hz,2H),4.87(d,J=6.9Hz,2H),5.54-5.60(m,1H),6.53(dd,J=2.4,8.1Hz,1H),6.68(d,J=2.7Hz,1H),6.80(d,J=7.8Hz,1H),7.01(d,J=8.4Hz,1H),7.06(s,1H),7.10(s,1H),7.60(dd,J=2.4,8.4Hz,1H),8 18(d,J=2.1Hz,1H)IR(KBr):3413,2926,2853,1607,1517,1479,1449,1376,1281,1240,1033,977cm-1.
Ⅰb-229 mp110-112℃；1H NMR(CDCl3)δ1.17-1.79(m,8H),1.79(s,3H),1.82(s,3H),2.07-2.14(m,2H),2.14(s,3H),2.26(s,3H),3.23-3.30(m,1H),3.73(brs,1H),4.87(d,J=6.9Hz,2H),5.54-5.60(m,1H),6.52(dd,J=2.1,8.1Hz,1H),6.68(d,J=2.7Hz,1H),6.80(d,J=8.7Hz,1H),7.01(d,J=8.4Hz,1H),7.06(s,1H)；7.09(s,1H),7.60(dd,J=2.7,8.7Hz,1H),8.18(d,J=1.8Hz,1H)IR(KBr):3411,3310,2926,2852,1607,1517,1479,1376,1357,1302,1284,1241.1013,980cm-1
                          表110
Ⅰb-230 mp油；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.79(s,3H),1.82(s,3H),2.14(s,3H),2.27(s,3H),3.71(d,J=6.6Hz,2H),4 87(d,J=6.9Hz,2H),5.33-5.37(m,1H),5.55-5.60(m,1H),6.55(dd,J=2.4,8.4Hz,1H),6.71(d,J=2.4Hz,1H),6.81(d,J=8.7Hz,1H),7.03(d,J=8.1Hz,1H),7.06(s,1H),7.09(s,1H),7.61(dd,J=2.7,8.7Hz,1H),8.18(d,J=2.4Hz,1H)IR(CDCl3):3017,2975,1607,1517,1479,1378,1358,1282,1240,1227,1220,977cm-1
Ⅰb-231 mp137-139℃；1H NMR(CDCl3)δ1.05-1.80(m,8H),1.79(s,3H),1.82(s,3H),2.05-2.12(m,2H),2.22(s,3H),2.26(s,3H),3.22-3.30(m,1H),3.75(brs,1H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.34-6.44(m,2H),6.81(d,J=9.0Hz,1H),7.03(d,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.59(dd,J=2.4,8.4Hz,1H),8.17(d,J=2.7Hz,1H)IR(KBr):3331,2924,2852,1628,1605,1526,1481,1452,1425,1375,1334,1302,1283,1241,1176,1114,1016,986cm-1
Ⅰb-232 mp108-109℃；1H NMR(CDCl3)δ1.48-1.78(m,6H),1.79(s,3H),1.82(s,3H),2.00-2.09(m,2H),2.22(s,3H),2.26(s,3H),3.75-3.83(m,1H),3.84-3.90(m,1H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.35-6.45(m,2H),6.80(d,J=8.4Hz,1H),7.04(t,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.59(dd,J=2.7,8.4Hz,1H),8.17(dd,J=0.6,2.4Hz,1H)IR(KBr):3328,2955,2866,1627,1605,1526,1481,1423,1394,1356,1337,1283,1240,1176,1116,1016,974cm-1
Ⅰb-233 mp77-79℃；1H NMR(CDCl3)δ1.00(d,J=0.6Hz,3H),1.02(d,J=0.6Hz,3H),1.79(s,3H),1.82(s,3H),1.86-1.99(m,1H),2.22(s,3H),2.26(s,3H),2.24(d,J=13.2Hz,2H),3.90(brs,1H),4.87(d,J=6.6Hz,2H),5.54-5.60(m,1H),6.34-6.50(m,2H),6.81(d,J=8.7Hz,1H),7.05(t,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.59-7.61(m,1H),8.16-8.17(m,1H)IR(KBr):3340,2958,2928,2866,1627,1606,1530,1481,1395,1358,1337,1284,1241,1178,1115,1046,991cm-1
Ⅰb-234 mp109-111℃；1H NMR(CDCl3)δ1.25(t,J=7.2Hz,3H),1.78(s,3H),1.82(s,3H),2.22(s,3H),2.26(s,3H),2.62-2.70(m,2H),4.19(brs,1H),4.31(s,1H),4.84(d,J=6.6Hz,2H),5.54-5,60(m,1H),6.39-6.50(m,2H),6.81(d,J=9.0Hz,1H),7.06(t,J=8.4Hz,1H),7.10(s,1H)；7.12(s,1H),7.21(d,J=8.1Hz,2H),7.32(d,J=8.1Hz,2H),7.59(dd,J=2.7,8.4Hz,1H),8.17(d,J=1.8Hz,1H)IR(KBr):3286,2967,2927,2871,1628,1598,1529,1481,1469,1376,1356,1336,1274,1237,1173,1149,1121,1003,975cm-1
Ⅰb-235 mp油；1H NMR(CDCl3)δ1.26(s,3H),1.27(s,3H),1.79(s,3H),1.82(s,3H),；2.22(s,3H),2.26(s,3H),2.87-2.99(m,1H),4.31(s,2H),4.87(d,J=7.5Hz,2H),5.55-5.60(m,1H),6.40-6.51(m,2H),6.81(d,J=8.7Hz,1H),7.07(t,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.17(d,J=8.1Hz,2H),7.33(d,J=8.1Hz,2H),7.57-7.61(m,1H),8.16-8.18(m,1H)IR(CDCl3):8010,2964,1628,1603,1523,1480,1357,1282,1241,977cm-1
Ⅰb-236 mp203-204℃；1H NMR(CDCl3)δ1.73(s,3H),1.75(s,3H),2.19(s,3H),2.21(s,3H),4.39(d,J=4.5Hz,2H),4.81(d,J=6.9Hz,2H),5.47-5.52(m,1H),6.48-6.49(m,1H),6.62(d,J=8.4Hz,2H),6.85(d,J=8.4Hz,1H),7.05-7.09(m,4H),7.50(d,J=8.1Hz,2H),7.71(dd,J=2.4,8.7Hz,1H),7.92(d,J=8.1Hz,2H),8.13(d,J=2.1Hz,1H)IR(KBr):3422,3004,1686,1609,1523,1482,1423,1392,1377,1356,1283,1240,1182,1124,977cm-1
                          表111
Ⅰb-237 mp144-147℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.26(s,3H),2.29(s,3H),3.92(s,3H),4.46(s,3H),4.46(s,2H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.65-6.70(m,2H),6.76(d,J=8.4Hz,2H),7.17-7.21(m,2H),7.47-7.50(m,2H),7.59(dd,J=2.7,8.4Hz,2H),8.01-8.05(m,2H),8.16(d,J=2.7Hz,1H)IR(KBr):3366,2951,1709,1609,1523,1478,1469,1437,1313,1282,1235,1180,1115,1105,1019,987cm-1
Ⅰb-238 mp75-76℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.79(s,3H),1.82(s,3H),2.06(s,3H),2.08(s,3H),2.25(s,3H),3.72(d,J=6.9Hz,2H),4.87(d,J=6.9Hz,2H),5.35-5.60(m,2H),6.49-6.55(m,2H),6.79-7.08(m,4H),7.60(dd,J=2.7,8.4Hz,1H),8.18(dd,J=0.9,2.7Hz,1H)IR(KBr):3331,2965,2916,1610,1522,1480,1449,1393,1302,1283,1251,1240,977cm-1
Ⅰb-239 mp87-89℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(m,3H),2.30(s,3H),3.82(d,J=5.4Hz,2H),4.87(d,J=6.9Hz,2H),5.18-5.36(m,2H),5.54-5.60(m,1H),5.93-6.06(m,1H),6.66-6.71(m,2H),6.80(d,J=8.7Hz,1H),7.10(s,1H),7.15(s,1H),7.17-7.22(m,2H),7.58(dd,J=2.4,8.4Hz,1H),8.16(dd,J=0.6,2.4Hz,1H)IR(KBr):3330,3007,2973,2855,1610,1526,1481,1470,1392,1376,1354,1299,1283,1266,1240,1129,1019,988cm-1
Ⅰb-240 mp 113-114℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.25-2.27(m,4H),2.29(s,3H),3.99(d,J=2.4Hz,2H),4.87(d,J=5.1Hz,2H),5.50-5.60(m,1H),6.73-6.78(m,2H),6.81(dd,J=0.6,8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.21-7.25(m,2H),7.59(dd,J=2.7,8.4Hz,1H),8.17(dd,J=0.6,2.4Hz,1H)IR(KBr):3311,3271,2974,2924,1609,1525,1481,1392,1377,1352,1320,1300,1283,1265,1239,1182,1121,987cm-1
Ⅰb-241 mp125-126℃；1H NMR(CDCl3)δ0.94-1.87(m,11H),1.78(s,3H),1.82(s,3H),2.26(s,3H),2.30(s,3H),3.00(d,J=6.6Hz,2H),4 87(d,J=6.9Hz,2H),5.54-5.60(m,1H),6.60-6.67(m,2H),6.81(d,J=8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.16-7.21(m,2H),7.58(dd,J=2.4,8.4Hz,1H),8.17(dd,J=0.6,2.1Hz,1H)IR(KBr):3356,2919,2851,1613,1528,1482,1470,1447,1395,1355,1325,1299,1284,1262,1241,1182,1020,985cm-1
Ⅰb-242 mp173-175℃；1H NMR(CDCl3)δ1,14-1,787(m,8H),1.78(s,3H),1.81(s,3H),2,08-2,12(m,2H),2,27(s,3H),2.30(s,3H),3.26-3.34(m,1H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.62-6.67(m,2H),6.81(dd,J=0.6,8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.15-7.19(m,2H),7.58(dd,J=2.4,8.7Hz,1H),8.16(dd,J=0.6,2.4Hz,1H)IR(KBr):3326,2922,2852,1611,1523,1482,1452,1393,1354,1319,1300,1282,1239, 1182,1125,983cm-1
Ⅰb-243 mp141-142℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.26(s,3H),2.28(s,3H),4.27(brs,1H),4.43(brs,2H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.63-6.66(m,2H),6.81(d,J=8.4Hz,1H),7.09(s,1H),7.13(s,1H),7.17-7.20(m,2H),7.33-7.35(m,2H),7.57(dd,J=2.1,8.4Hz,1H),8.16(d,J=2.4Hz,1H),8.57-8.59(m,2H)IR(KBr):3279,2972,2925,1603,1522,1479,1459,1418,1375,1351,1318,1282,1272,1240,1179,1120,1001,cm-1
                              表112
Ⅰb-244 mp123-125℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.26(s,3H),2.29(s,3H),4.38(s,2H),4.87(d,J=6.9Hz,2H),5.54-5.60(m,1H),6.69-6.73(m,2H),6.81(dd,J=0.6,8.4Hz,1H),7.09(s,1H),7.14(s,1H),7.17-7.22(m,2H),7.26-7.44(m,5H),7.58(dd,J=2.4,8.4Hz,1H),8.16(d,J=1.8Hz,1H)IR(KBr):3348,2966,2921,1613,1527,1482,1469,1453,1394,1356,1326,1297,1285,1264,1241,1020,987cm-1
Ⅰb-245 mp137-138℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.28(s,6H),3.33(s,3H),4.55(brs,2H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.81(dd,J=0.6,8.7Hz,1H),7.12-7.14(m,2H),7.35-7.39(m,2H),7.44-7.49(m,2H),7.59(dd,J=2.4,8.4Hz,1H),8.17(dd,J=0.6,2.4Hz,1H),IR(KBr):3376,3284,2972,2922,1604,1480,1462,1342,1281,1180,1140,999cm-1
Ⅰb-246 mp118-120℃；1H NMR(CDCl3)δ1.78(s,3H),1.87(s,3H),2.26(s,3H),2.30(s,3H),4.39(s,2H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.70-6.73(m,2H),6.80(d,J=8.4Hz,1H),7.10-7.14(m,3H),7.15-7.24(m,3H),7.34(dd,J=3.0,5.1Hz,1H),7.59(dd,J=2.4,8.4Hz,1H),8.17(d,J=1.8Hz,1H)IR(KBr):3397,2973,2920,2851,1610,1522,1480,1470,1376,1350,1298,1280,1260,1235,1182,1122,980cm-1
Ⅰb-247 mp112-115℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(s,3H),2.30(s,3H),4.22(s,2H),4.87(d,J=6.9Hz,2H),5.55-5.60(m,1H),6.44-6.45(m,1H),6.70-6.74(m,2H),6.81(dd,,J=0.9,8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.18-7.23(m,1H),7.41-7.45(m,1H),7.59(dd,J=2.4,8.7Hz,1H),8.17(dd,J=0.6,2.4Hz,1H),IR(KBr):3338,2924,1613,1526,1501,1482,1471,1394,1355,1317,1298,1285,1241,1156,1020,977cm-1
Ⅰb-248 mp123-125℃；1H NMR(CDCl3)δ1.78(s,3H),1.81(s,3H),2.27(s,3H),2.29(s,3H),2.60(brs,3H),4.87(d,J=7.2Hz,2H),5.54-5.60(m,1H),6.73-6.77(m,2H),6.8(d,J=8.4Hz,1H),7.09(s,1H),7.14(s,1H),7.14-7.18(m,2H),7.59(dd,J=2.4,8.4Hz,1H),8.17(d,J=2.4Hz,1H),IR(KBr):3449,3341,2972,2925,1623,1604,1521,1481,1394,1359,1281,1241,1128,984cm-1
Ⅰb-249 mp70-72℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(s,3H),2.30(s,3H),2.89(s,3H),4.87(d,J=7.2Hz,2H),5.55-5.60(m,1H),6.66-6.71(m,2H),6.81(dd,J=0.9,8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.19-7.23(m,2H),7.59(dd,J=2.7,8.4Hz,1H),8.17(dd,J=0.6,2.4Hz,1H),IR(KBr):3356,2923,2883,1614,1603,1529,1482,1393,1357,1320,1298,1282,1264,1241,1182,981cm-1
Ⅰb-250 mp87-88℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.79(s,3H),1.80(s,3H),2.22(s,3H),2.26(s,3H),3.71(d,J=6.9Hz,2H),4.87(d,J=7,2Hz,2H),5.32-5.37(m,1H),5.55-5.60(m,1H),6.35-6.47(m,2H),6.81(dd,J=0.6,8.4Hz,1H),7.02-7.13(m,3H),7.59(dd,J=2.4,8.4Hz,1H),8.16(dd,J=0.9,5.7Hz,1H),HR(Nujol):3330,2923,2853,1627,1606,1564,1527,1481,1471,1395,1376,1357,1337,1284,1240,1178,1116,990cm-1
                        表113
Ⅰb-251 mp102-103℃；1H NMR(CDCl3)δ1.75(s,3H),1.79(s,6H),1.82(s,3H),2.19(s,3H),2.27(s,3H),2.31(s,3H),3.49(brs,1H),3.78(d,J=6.9Hz,2H),4.87(d,J=6.9Hz,2H),5.42(t,J=6.9Hz,1H),5.57(t,J=7.2Hz,1H),6.68(d,J=8.1Hz,1H),6.80(d,J=8.4Hz,1H),7.09(s,2H),7.13-7.17(m,2H),7.59(dd,J=2.7,8.4Hz,1H),8.17(d,J=2.4Hz,1H)；IR(KBr):3363,2969,2918,2884,2854,1609,1601,1517,1482,1468,1442,1378,1283,1250,981,891cm-1.
Ⅰb-252 mp109-110℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.23(s,3H),2.27(s,3H),2.30(s,3H),3.85(brs,1H),4.42(s,2H),4.87(d,J=7.2Hz,2H),5.57(t,J=6.6Hz,1H),6.69(d,J=8.1Hz,1H),7.09-7.15(m,4H),7.31-7.44(m,5H),7.59(dd,J=2.4,8.7Hz,1H),8.17(d,J=1.5Hz,1H)；IR(KBr):3431,3351,2970,2919,2854,1602,1517,1483,1466,1451,1377,1285,1250,1132,975,836cm-1.
Ⅰb-253 mp72-73℃；1H NMR(CDCl3)δ1.75(s,3H),1.79(s,6H),1.82(s,3H),2.27(s,3H),2.30(s,3H),3.77(d,J=6.9Hz,2H),3.92(brs,1H),4.87(d,J=7.2Hz,2H),5.38(t,J=6.9Hz,1H),5.57(t,J=6.9Hz,1H),6.74(dd,J=8.1,8.7Hz,1H),6.81(dd,J=0.9,6.3Hz,1H),6.99-7.00(m,1H),7.00(s,1H),7.03(s,1H),7.14(s,1H),7.58(dd,J=2.7,8.7Hz,1H),8.16(d,J=2.7Hz,1H)；IR(KBr):3431,2971,2915,1624,1599,1528,1479,1465,1335,1241,1122,987,833cm-1.
Ⅰb-254 mp106-107℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.26(s,3H),2.29(s,3H),4.42(s,2H),3.85(brs,1H),4.87(d,J=7.2Hz,2H),5.57(t,J=7.2Hz,1H),6.73(dd,J=8.7,8.7Hz,1H),6.81(d,J=8.4Hz,1H),6.96-6.99(m,1H),7.03(d,J=12.9Hz,1H),7.10(d,J=9.9Hz,2H),7.26-7.43(m,5H),7.58(dd,J=2.4,8.4Hz,1H),8.16(d,J=1.8Hz,1H)；IR(KBr):3428,2922,2857,1623,1601,1566,1500,1427,1391,1376,1308,1298,1149,1134,1074,1038,1018,927,895cm-1.
Ⅰb-255 mp83-84℃；1H NMR(CDCl3)δ1.75(s,3H),1.79(s,6H),1.82(s,3H),2.27(s,3H),2.30(s,3H),3.79(d,J=6.3Hz,2H),4.29(brs,1H),4.87(d,J=7.2Hz,2H),5.39(t,J=6.6Hz,1H),5.57(t,J=7.2Hz,1H),6.71(d,J=8.7Hz,1H),6.81(d,J=8.1Hz,1H),7.10(s,1H),7.13(s,1H),7.16(dd,J=2.1,8.4Hz,1H),7.27(dd,J=2.1,7.5Hz,1H),7.58(dd,J=2.7,8.7Hz,1H),8.16(d,J=1.8Hz,1H)；IR(KBr):3420,3356,2968,2924,1603,1520,1482,1468,1284,1248,1078,981,838cm-1.
Ⅰb-256 mp89-90℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.26(s,3H),2.29(s,3H),4.46(s,2H),4.79(brs,1H),4.87(d,J=6.9Hz,2H),5.57(t,J=7.2Hz,1H),6.69(d,J=8.1Hz,1H),6.81(d,J=8.7Hz,1H),7.09-7.13(m,3H),7.31-7.43(m,6H),7.58(dd,J=2.7,8.7Hz,1H),8.16(d,J=2.4Hz,1H)；IR(KBr):3422,3340,2975,2923,1604,1520,1482,1455,1286,1248,975,887cm-1.
Ⅰb-257 mp62-63℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.79(s,3H),1.82(s,3H),2.28(s,3H),2.32(s,3H),3.76(d,J=6.6Hz,2H),3.86(s,3H),4.27(brs,1H),4.87(d,J=6.9Hz,2H),5.41(t,J=6.6Hz,1H),5.58(t,J=6.9Hz,1H),6.67(d,J=8.1Hz,1H),6.78-6.79(m,2H),6.88(dd,J=1.8,8.1Hz,1H),7.11(s,1H),7.18(s,1H),7.59(dd,J=2.4,8.4Hz,1H),8.17(d,J=1.8Hz,1H)；IR(KBr):3437,2880,2856,1560,1416,1378,1306,1176,1075,1017,948,898,883cm-1.
                          表114
Ⅰb-258 mp86-87℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(s,3H),3.31(s,3H),3.87(s,3H),4.40(s,2H),4.67(brs,1H),4.87(d,J=6.9Hz,2H),5.57(t,J=7.2Hz,1H),6.65(d,J=7.8Hz,1H),6.79-6.86(m,3H),7.10(s,1H),7.17(s,1H),7.31-7.44(m,5H),7.59(dd,J=2.4,8.7Hz,1H),8.17(d,J=2.4Hz,1H)；IR(KBr):3426,2948,2914,2857,1600,1561,1525,1415,1304,1177,1018,948,900,883cm-1.
Ⅰb-259 mp108-109℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.79(s,3H),1.82(s,3H),2.27(s,3H),2.31(s,3H),3.66(brs,1H),3.74(d,J=6.8Hz,2H),4.87(d,J=7.1Hz,2H),5.38(brt,J=6.8Hz,1H),5.58(brt,J=7.1Hz,1H),6.67(d,J=8.5Hz,2H),6.81(dd,J=0.7,8.6Hz,1H),7.10(s,1H),7.15(s,1H),7.20(d,J=8.5Hz,2H),7.59(dd,J=2.4,8.6Hz,1H)8.17(dd,J=0.7,2.4Hz,1H)
Ⅰb-260 mp74-75℃；1H NMR(CDCl3)δ1.72(s,3H),177(s,3H),1.81(s,6H),2.29(s,3H),2.31(s,3H),3.76(d,2H,J=6.9Hz),5.07(d,J=7.2Hz,2H),5.39(m,1H),5.58(m,1H),6.77(d,J=7.8Hz,2H),7.11-7.23(m,5H),8.26(d,J=2.1Hz,1H),8.40(d,J=2.1Hz,2H)；IR(CHCl3):3426,2975,2918,2862,1612,1556,1528,1498,1471,1379,1854,1299,1241,12256,1185,1091,970,947cm-1
Ⅰb-261 1H NMR(DMSO)δ1.73(s,3H),1.76(s,3H),2.22(s,3H),2.23(s,3H),4.82(d,J=6.9Hz,2H),5.50(t,J=6.9Hz,1H),6.86(d,J=8.4Hz,1H),6.96-7.05(m,2H),7.11-7.17(m,3H),7.72(dd,J=2.7,8.7Hz,1H),8.15(d,J=2.7Hz,1H),9.94(brs,1H)；IR(neat)；3350,2964,1601,1520,1480,1377,1355,1283,1241,1113,979,755cm-1
Ⅰb-262 mp96℃1H NMR(DMSO)δ1.74(s,6H),1.76(s,3H),1.77(s,3H),2.22(s,3H),2.34(s,3H),4.65(d,J=6.9Hz,2H),4.82(d,J=6.6Hz,2H),5.44-5.54(m,2H),7.10-7.18(m,3H),7.21-7.27(m,2H),7.73(dd,J=2.4,8.4Hz,1H),8.15(d,J=2.4Hz,1H),；IR(nujol):1600,1517,1280,1269,1127,995,836cm-1
Ⅰb-263 mp78-79℃1H NMR(CD3OD)δ1.79(s,3H),1.80(s,3H),2.42(s,6H),3.92(s,3H),4.83(d,J=7.0Hz,2H),5.50-5.56(m,1H),6.84(dd,J=0.6,8.7Hz,1H),7.05-7.18(m,5H),7.67(dd,J=2.7,8.7Hz,1H),8.07(dd,J=2.7,0.6Hz,1H),；IR(nujol):1600,1577,1280,1270,1127,983,838cm-1
Ⅰb-264 mp80-81℃1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.72(s,6H),4.88(d,J=7.2Hz,2H),5.13(s,2H),5.55-5.60(m,1H),6.40(dd,J=1.5,3.6Hz,1H),6.48(d,J=3.6Hz,1H),6.82(d,J=8.4Hz,1H),7.02-7.06(m,1H),7.08-7.16(m,4H),7.47-7.48(m,1H),7.58(dd,J=2.7,8.4Hz,1H)8.16(d,J=2.7Hz,1H)；IR(nujol):1601,1518,1281,1125,984,834cm-1
Ⅰb-265 mp105℃1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(s,6H),4.88(d,J=7.2Hz,2H),5.20(s,2H),5.50-5.60(m,1H),6.81(d,J=8.4Hz,1H),7.00-7.15(m,5H),7.32-7.50(m,5H),7.58(dd,J=2.4,8.4Hz,1H)8.16(d,J=2.4Hz,1H)；IR(nujol):1602,1299,1276,1128,974,749cm-1
Ⅰb-266 mp188-190℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.27(s,3H),2.29(s,3H),4.88(d,J=7.1Hz,2H),4.89(s,2H),5.58(t,J=7.1Hz,2H),6.83(dd,J=8.4,0.6Hz,1H),7.13(s,1H),7,15(s,1H),7.50-7.55(m,2H),7.59(dd,J=8.4,2.4Hz,1H),7.97-8.02(m,2H),8.16(dd,J=2.4,0.6Hz,1H)；IR(KBr):3367,3321,3271,1602,1479,1333,1281,1163,1153,995,980,785,607,553cm-1
                         表115
Ⅰb-267 mp176-178℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.19(s,3H),2.28(s,3H),4.88(d,J=6.9Hz,2H),4.96(s,2H),5.57(t,J=7.1Hz,2H),6.82(dd,J=8.4,0.6Hz,1H),7.11(s,1H),7,15(s,1H),7.47(t,J=8.1Hz,1H),7.59(dd,J=8.4,2.6Hz,1H),7.74(dd,J=9.0,1.8Hz,1H),7.80(dd,J=8.1,1.8Hz,1H),8.16(dd,J=2.6,0.6Hz,1H)；IR(KBr):3352,3261,1603,1479,1317,1152,993,831,777,600cm-1
Ⅰb-268 油；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(s,3H),1.81(s,3H),2.05(s,3H),2.19(s,3H),2.26(s,3H),3.72(d,J=6.6Hz,2H),3.77(brs,1H),4.85(m,2H),5.35(m,1H),5.56(m,1H),6.34(dd,J=2.1,9.3Hz,1H),6.45(dd,J=2.1,8.4Hz,1H),6.61(d,J=8.4Hz,1H),6.97(s,1H),7.07(t,J=8.4Hz,1H),7.34(d,J=8.4Hz,1H)
Ⅰb-269 油；1H NMR(CDCl3)δ1.74(s,3H),1.8(s,6H),1.82(s,3H),2.21(s,3H),2.25(s,3H),2.27(s,3H),3.71(d,J=6.6Hz,2H),4.89(d,J=6.6Hz,2H),5.35(brt,J=6.6Hz,1H),5.57(brt,J=6.6Hz,1H),6.39(dd,J=2.1,12.6Hz,1H),6.45(dd,J=2.1,8.4Hz,1H),7.06(t,J=8.4Hz,1H),7.10(s,1H),7.12(s,1H),7.41(d,J=2.4Hz,1H),8.01(d,J=2.4Hz,1H)
Ⅰb-270 油；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,6H),1.82(s,3H),2.05(s,3H),2.07(s,3H),2.20(s,3H),3.72(d,J=6.6Hz,2H),3.85(br,1H),4.85(d,J=7.8Hz,2H),5.36(m,1H),5.56(m,1H),6.39(dd,J=2.4,12.3Hz,1H),6.45(dd,J=2.4,8.1Hz,1H),6.68(s,1H),6.97(s,1H),7.07(t,J=8.4Hz,1H),7.10(s,1H),7.93(s,1H)
Ⅰb-271 油；1H NMR(CDCl3)δ1.78(s,3H),1.81(s,3H),2.20(s,3H),2.25(s,3H),2.27(s,3H),4.90(d,J=6.6Hz,2H),5.58(brt,J=6.9Hz,1H),6.47(dd,J=2.1,11.4Hz,1H),6.53(dd,J=2.1,8.1Hz,1H),7.05(t,J=8.1Hz,1H),7.10(s,1H),7.11(s,1H),7.41(d,J=2.1Hz,1H),8.01(d,J=2.1Hz,1H)
Ⅰb-272 油；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.05(s,3H),2.07(s,3H),2.19(s,3H),3.85(brs,2H),4.85(d,J=6.9Hz,2H),5.56(m,1H),6.48(dd,J=2.1,11.7Hz,1H),6.53(dd,J=2.1,8.4Hz,1H),6.68(s,1H),6.98(s,1H),7.07(t,J=8.4Hz,1H),7.10(s,1H),7.92(s,1H)
Ⅰb-273 油；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.805(s,3H),1.810(s,3H),2.06(s,3H),2.26(s,3H),2.28(s,3H),3.74(d,J=6.6Hz,2H),4.83-4.87(m,2H),5.38(m,1H),5.56(m,1H),6.61(d,J=8.4Hz,1H),6.68(d,J=9.0Hz,2H),6.96(s,1H),7.21(d,J=9.0Hz,2H),7.34(d,J=8.4Hz,1H)
Ⅰb-274 油；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.78(s,3H),1.81(s,3H),2.25(s,3H),2.27(s,3H),2.30(s,3H),3.74(d,J=6.6Hz,2H),4.89(d,J=6.9Hz,2H),5.38(m,1H),5.58(m,1H),6.68(d,J=8.7Hz,2H),7.09(s,1H),7.15(s,1H),7.20(d,J=8.7Hz,2H),7.41(m,1H),8.01(m,1H)
Ⅰb-275 油；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,6H),1.81(s,3H),2.05(s,3H),2.07(s,3H),2.28(s,3H),3.74(d,J=6.9Hz,2H),4.85(d,J=7.5Hz,2H),5.38(m,1H),5.56(m,1H),6.67-6.71(m,3H),6.96(s,1H),7.12(s,1H),7.21(d,J=8.7Hz,1H),7.92(s,1H)
Ⅰb-276 油；1H NMR(CDCl3)δ1.75(s,3H),1.81(s,3H),2.05(s,3H),2.06(s,3H),2.26(s,3H),3.75(br,2H),4.84-4.87(m,2H),5.57(m,1H),6.62(d,J=8.1Hz,1H),6.74-6.77(m,3H),6.96(s,1H),7.11(s,1H),7.17-7.20(m,2H),7.34(d,J=8.1Hz,1H)
                             表116
Ⅰb-277 油；1H NMR(CDCl3)δ1.78(s,3H),1.81(s,3H),2.25(s,3H),2.27(s,3H),2.28(s,3H),4.90(d,J=6.8Hz,2H),5.58(m,1H),6.73-6.78(m,2H),7.08-7.41(m,5H),8.00(d,J=2.2Hz,1H)
Ⅰb-278 油；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.05(s,3H),2.08(s,3H),2.27(s,3H),4.85(d,J=8.1Hz,2H),5.57(m,1H),6.68(s,1H),6.75-6.78(m,2H),6.97(s,1H),7.12(s,1H),7.17-7.21(m,2H),7.92(s,1H)
Ⅰb-279 mp102-103℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),2.26(s,3H),2.31(s,3H),3.74(d,J=6.9Hz,2H),4.56-4.60(m,1H),4.66-4.73(m,2H),4.86-4.89(m,1H),5.35-5.40(m,1H),6.65-6.70(m,2H),6.86(d,J=8.4Hz,1H),7.09(s,1H),7.16(s,1H),7.18-7.22(m,2H),7.62(dd,J=2.4,8.7Hz,1H),8.13-8.14(m,1H)IR(KBr):3356,2983,2925,1611,1526,1482,1452,1391,1348,1307,1289,1263,1242,1073,1020cm-1
Ⅰb-280 mp81-82℃；1H NMR(CDCl3)δ2.27(s,3H),2.30(s,3H),3.82-3.84(m,2H),4.88-4.91(m,2H),5.18-5.47(m,4H),5.93-6.21(m,2H),6.67-6.71(m,2H),6.83(d,J=8.4Hz,1H),7.09(s,1H),7.15(s,1H),7.17-7.22(m,2H),7.61(dd,J=2.4,7.2Hz,1H),8.16(dd,J=0.9,2.4Hz,1H)IR(KBr):3342,3007,2921,1609,1524,1482,1391,1314,1279,1182,1020,996cm-1
Ⅰb-281 mp142-144℃；1H NMR(CDCl3)δ2.20-2.27(m,4H),2.29(s,3H),2.50(s,1H),3.99(d,J=2.4Hz,1H),5.04(d,J=2.7Hz,1H),6.73-6.78(m,2H),6.87(dd,J=2.4,8.7Hz,1H),7.10(s,1H),7.16(s,1H),7.21-7.26(m,2H),7.63(dd,J=2.4,8.7Hz,1H),8.18(dd,J=0.9,2.4Hz,1H)IR(KBr):3360,3292,3266,3005,1608,1523,1479,1438,1391,1299,1280,1265,1233,1022,1010cm-1
Ⅰb-282 mp65-68℃；1H NMR(CDCl3)δ1.58(s,3H),1.70(s,3H),1.73(s,3H),1.78(s,3H),2.23(s,3H),2.26(s,3H),2.43-2.50(m,2H),2.87(t,J=7.5Hz,2H),3.71(d,J=6.9Hz,2H),3.79(brs,1H),5.20-5.36(m,2H),6.36-6.47(m,2H),7.06(t,J=8.4Hz,1H),7.12(s,1H),7.14(s,1H),7.19(d,J=7.8Hz,1H),7.60(dd,J=2.1,7.8Hz,1H),8.55(d,J=1.8Hz,1H)IR(KBr):3427,3274,2965,2913,2854,1629,1536,1480,1443,1421,1375,1343,1305,1276,1245,1173,1115,1023cm-1
Ⅰb-283 mp112-113℃；1H NMR(CDCl3)δ1.69(s,3H),1.70(s,3H),1.73(s,3H),1.77(s,3H),2.22(s,3H),2.23(s,3H),3.83-3.88(m,2H),4.64(d,J=7.2Hz,2H),5.28-5.33(m,1H),5.46-5.51(m,1H),6.50-6.61(m,2H),7.07-7.11(m,3H),7.19-7.26(m,2H),7.40(dd,J=2.7,8.7Hz,1H),7.97(d,J=2.4Hz,1H),IR(KBr):3222,2971,2922,2858,1605,1536,1493,1468,1428,1396,1318,1297,1272,1262,1229,1194,1125,1090,996cm-1
Ⅰb-284 mp141-143℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,6H),1.82(s,3H),2.28(s,3H),2.29(s,3H),3.85-3.95(m,2H),4.56(d,J=6.6Hz,2H),5.36(m,1H),5.54(tm,J=6.6Hz,1H),6.45(m,1H),6.97(d,J=8.7Hz,2H),7.11(s,1H),7.14(s,1H),7.28(d,J=8.7Hz,2H),7.47(m,1H),8.13(m,1H)；IR(KBr)3433,3220,1610,1536,1492,1233,1176.998,844cm-1.
Ⅰb-285 mp113-114℃；1H NMR(DMSO-d6)δ1.73(s,3H),1.77(s,3H),2.22(s,6H),4.64(d,J=6.9Hz,2H),5.46-5.50(m,1H),5.98(s,2H),6.51(d,J=8.4Hz,1H),7.07-7.11(m,3H),7.19-7.26(m,2H),7.41(dd,J=2.7,8.4Hz,1H),7.90(d,J=2.7Hz,1H),IR(KBr):3456,3292,3173,2917,1631,1617,1521,1485,1442,1395,1378,1298,1268,1232,1193,1126,1004cm-1
                           表117
Ⅰb-286 mp134-136℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.28(s,6H),4.56(d,J=6.6Hz,2H),5.54(tm,J=6.6Hz,1H),6.58(m,1H),6.98(d,J=90Hz,2H),7.10(s,1H),7.14(s,1H),7.28(d,J=9.0Hz,2H),7.48(m,1H),8.10(m,1H)；IR(KBr)3458,3300,3176,1630,1614,1519,1485,1238,1003,837cm-1.
Ⅰb-287 mp187-189℃；1H NMR(CDCl3)δ1.15-1.54(m,4H),1.58-1.86(m,4H),1.77(s,3H),1.82(s,3H),2.02-2.15(m,2H),2.28(s,3H),2.29(s,3H),3.58(m,1H),4.56(d,J=6.9Hz,2H),5.54(tm,J=6.9Hz,1H),5.54(m,1H),6.44(m,1H),6.97(d,J=8.7Hz,2H),7.10(s,1H),7.13(s,1H),7.28(d,J=8.7Hz,2H),7.45(m,1H),8.10(m,1H)；IR(KBr)3334,1612,1519,1488,1231,1006,833cm-1.
Ⅰb-288 mp89-90℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),2.22(s,3H),2.26(s,3H),3.71(d,J=6.9Hz,2H),5.32-5.36(m,1H),5.38(s,2H),6.36-6.49(m,4H),6.84(dd,J=0.6,8.4Hz,1H),7.06(t,J=8.1Hz,1H),7.11(s,1H),7.13(s,1H),7.46-7.48(m,1H),7.61(dd,J=2.4,8.4Hz,1H),8.18(dd,J=0.9,2.4Hz,1H)IR(KBr):3423,2963,2926,2860,1627,1604,1523,1480,1448,1393,1378,1343,1282,1269,1240,1169,1150,1117,1014,1000cm-1
Ⅰb-289 mp油℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.90(t,J=2.1Hz,3H),2.22(s,3H),2.26(s,3H),3.71(d,J=6.9Hz,2H),4.99-5.01(m,2H),5.33-5.37(m,1H),6.37-6.47(m,2H),6.86(d,J=8.4Hz,1H),7.03-7.13(m,3H),7.61(dd,J=2.4,8.4Hz,1H),8.17(d,J=2.1Hz,1H)
Ⅰb-290 mp104-105℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),2.24(s,3H),2.29(s,3H),3.72(d,J=6.9Hz,2H),5.33-5.36(m,1H),6.37-6.78(m,4H),7.06(t,J=8.4Hz,1H),7.14(s,1H),7.16(s,1H),7.38(d,J=8.4Hz,1H),7.56(t,J=2.4Hz,1H),7.77(dd,J=2.1,8.1Hz,1H),8.45(dd,J=0.6,2.4Hz,1h)IR(KBr):3396,2976,2929,2855,1626,1596,1573,1523,1482,1378,1367,1335,1130,1065cm-1
Ⅰb-291 mp119-120℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),2.01-2.06(m,4H),2.21(s,3H),2.29(s,3H),3.49-3.54(m,4H),3.71(d,J=6.6Hz,2H),5.33-5.36(m,1H),6.35-6.46(m,3H),7.06(t,J=8.4Hz,1H),7.10(s,2H),7.48(dd,J=2.7,9.0Hz,1H),8.20(d,J=2.1Hz,1H)IR(KBr):3438,2957,2914,2855,1628,1602,1540,1525,1490,1457,1416,1341,1306,1235,1168,1115cm-1.
Ⅰb-292 油；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.27(s,3H),2.30(s,3H),4.56(d,J=6.9Hz,2H),5.55(tm,J=6.9Hz,1H),6.99(d,J=8.7Hz,2H),7.13(s,1H),7.17(s,1H),7.29(d,J=8.7Hz,2H),7.37(m,1H),7.45(m,H),8.56-8.70(m,2H)；IR(CHCl3)1672,1607,1514,1494,1471,1450,1383,1234,1230,1174,998,978cm-1.
Ⅰb-293 mp114-115℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),2.26(s,3H),2.31(s,3H),3.74(d,J=6.9Hz,2H),3.99(s,3H),5.35-5.44(m,1H),6.65-6.70(m,2H),6.81(d,J=8.4Hz,1H),7.10(s,1H),7.16(s,1H),7.17-7.22(m,2H),7.60(dd,J=2.4,8.4Hz,1H),8.18(d,J=2.1Hz,1H)IR(KBr):3333,3006,2968,1612,1524,1483,1387,1367,1319,1300,1288,1240,1024cm-1
Ⅰb-294 mp75-76℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),2.28(s,3H),2.31(s,3H),3.76(d,J=6.9Hz,2H),4.17(s,2H),5.39(m,1H),6.75(d,J=8.4Hz,2H),7.10-7.22(m,4H),8.29(d,J=2.4Hz,1H),8.42(d,J=2.4Hz,1H)；IR(CHCl3):3426,2923,2868,1613,1557,1530,1499,1478,1427,1381,1353,1301,1245,1093,1007,956,929,894cm-1
                            表118
Ⅰb-295 mp88-89℃1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.28(s,6H),4.64(d,J=6.9Hz,2H),5.44(s,2H),5.53-5.58(m,1H),6.89(dd,J=0.6,8.7Hz,1H),7.00-7.14(m,5H),7.32-7.44(m,3H),7.49-7.53(m,2H),7,62(dd,J=2.7,8.7Hz,1H)8.19(dd,J=0.6,2.7Hz,1H)；IR(nujol):1602,1285,1129,988,836cm-1.
Ⅰb-296 mp110℃1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.27(s,6H),2.28(s,3H),4.01(s,3H),4.64(d,J=6.9Hz,2H),5.53-5.58(m,1H),6.82(d,J=8.4Hz,1H),7.00-7.26(m,5H),7.60(dd,J=2.4,8.4Hz,1H),8.18(d,J=2.4Hz,1H),；IR(nujol):1598,1283,1273,1124,992,838cm-1
Ⅰb-297 mp201-204℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),1.97(s,6H),1.98(s,6H),4.88(d,J=6.9Hz,2H),5.56-5.61(m,1H),6.75-6.80(m,2H),6.83(d,J=8.1Hz,1H),6.92-6.98(m,2H),7.41(dd,J=2.4,8.7Hz,1H),7.98(d,J=2.4Hz,1H)IR(KBr)；3452,3368,2927,1619,1599,1517,1487,1465,1378,1350,1275,1240,1125,980cm-1
Ⅰb-298 mp158-160℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.79(s,3H),1.83(s,3H),1.97(s,6H),2.00(s,6H),3.74(d,J=6,9Hz,2H),4.88(d,J=6.9Hz,2H),5.37-5.42(m,1H),5.56-5.62(m,1H),6.67-6.72(m,2H),6.84(d,J=8.4Hz,1H),6.94-7.00(m,2H),7.41(dd,J=2.4,8.7Hz,1H),7.99(dd,J=0.6,2.4Hz,1H)IR(KBr):3388,2928,2854,1613,1600,1518,1486,1465,1376,1349,1312,1291,1275,1240,1125,983cm-1
Ⅰb-299 mp124-125℃；1H NMR(CDCl3)δ1.25(s,3H),1.27(s,3H),1.80(s,3H),1.83(s,3H),1.97(s,6H),2.00(s,6H),3.62-3.75(m,1H),4.88(d,J=6.9Hz,2H),5.56-5.62(m,1H),6.64-6.68(m,2H),6.83(d,J=8.4Hz,1H),6.93-6.98(m,2H),7.41(dd,J=2.4,8.4Hz,2H),7.99(d,J=1.8Hz,1H)IR(KBr):3391,2965,2930,1613,1600,1519,1412,1376,1362,1349,1316,1277,1242,1181,1125,977cm-1
Ⅰb-300 mp116-119℃；1H NMR(CDCl3)δ1.78(s,3H)；1.82(s,3H)；1.97(s,12H)；4.01(s,3H)；4.64(d,J=6.6Hz,2H)；5.58(m,1H)；6.82-6.87(m,2H)；6.91(ddd,J=1.8,4.8,11.7Hz,1H)；7.05(dt,J=1.5,8.7Hz,1H)；7.41(ddd,J=1.5,2.4,8.7Hz,1H)7.99(d,J=2.4Hz,1H)；IR(KBr):3432,2944,1603,1514,1496,1462,1297,1281,1263,1245,1210,1113cm-1.
Ⅰb-301 mp150-153℃；1H NMR(CDCl3)δ1.75(s,3H)；1.780(s,3H)；1.784(s,3H)；1.82(s,3H)；1.96(s,6H)；2.01(s,6H)；3.91(t,J=6.0Hz,2H)；4.50(brt,J=4.5Hz,1H)；4.64(d,J=6.9Hz,2H)；5.38(m,1H)；5.57(m,1H)；6.49(m,1H)；6.84(m,1H)；6.91(ddd,J=2.1,3.3,12Hz,1H)；7.04(dt,J=2.1,8.4Hz,1H)；7.27(m,1H)；7.91(m,1H)；IR(KBr):3235,2917,1608,1540,1513,1381,1294,1261cm-1.
Ⅰb-302 mp155-157℃；1H NMR(CDCl3)δ1.30(d,J=6.3Hz,6H)；1.78(s,3H)；1.83(s,3H)；1.96(s,6H)；2.01(s,6H)；3.92(sept,J=6.3Hz,1H)；4.54(br,1H)；4.64(d,J=6.6Hz,2H)；5.58(m,1H)；6.48(d,J=7.5Hz,1H)；6.83-7.07(m,3H)；7.27(m,1H)；7.89(m,1H)；IR(KBr):3419,3249,2969,1610,1537,1513,1463,1389,1293,1263,1241,1209,1180,1113cm-1.
Ⅰb-303 mp134-137℃；1H NMR(CDCl3)δ0.99-1.92(m,11H)；1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；2.01(s,6H)；3.16(t,J=6.0Hz,2H)；4.64(d,J=6.6Hz,2H)；4.73(brs,1H)；5.57(m,1H)；6.49(m,1H)；6.82-6.94(m,2H)；7.04(dt,J=1.5,7.8Hz,1H)；7.27(m,1H)；7.88(m,1H)；IR(KBr):3425,3250,2925,2852,1607,1533,1512,1448,1294,1261,1240,1211,1115cm-1.
                             表119
Ⅰb-304 mp154-156℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.98(s,6H)；2.00(s,6H)；4.63(d,J=5.7Hz,2H)；5.00(br,1H)；5.57(m,1H)；6.52(dd,J=2.4,8.4Hz,1H)；6.85-7.01(m,2H)；7.04(dt,J=1.8,8.4Hz,1H)；7.26-7.33(m,2H)；7.77(m,1H)；7.994(m,1H)；8.56(m,1H)；8.69(brs,1H)；IR(KBr):3256,2917,1603,1514,1463,1427,1381,1296,1263,1239,1210,1112,1004cm-1.
Ⅰb-305 mp127-129℃；1H NMR(CDCl3)δ0.99(d,J=6.6Hz,6H)；1.50-1.80(m,3H)；1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；2.01(s,6H)；3.29-3.36(m,2H)；4.53(brt,1H)；4.64(d,J=6.6Hz,2H)；5.57(m,1H)；6.49(d,J=8.4Hz,1H)；6.81-6.94(m,2H)；7.04(dt,J=1.5,8.4Hz,1H)；7.28(m,2H)；7.90(m,1H)；IR(KBr):3442,3259,2956,1609,1542,1512,1457,1383,1293,1260,1238,1205,1114cm-1.
Ⅰb-306 mp86-89℃；1H NMR(CDCl3)δ1.04(d,J=6.6Hz,5H)；1.77(s,3H)；1.82(s,3H)；1.8-1.95(m,1H)；1.96(s,6H)；2.01(s,6H)；3.14(t,J=6.3Hz,2H)；4.64(d,J=6.9Hz,2H)；4.67(brt,1H).57(m,1H)；6.49(m,1H)；6.82-7.07(m,3H)；7.28(dt,J=1.8,8.4Hz,1H)；7.89(m,1H)；IR(KBr):3343,2957,1610,1513,1465,1382,1294,1263,1240,1114cm-1.
Ⅰb-307 mp157-159℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；2.00(s,6H)；4.64(d,J=6.6Hz,2H)；4.77(d,J=5.4Hz,2H)；4.94(br,1H)；5.57(m,1H)；6.56(m,1H)；6.81-7.09(m,5H)；7.24-7.30(m,2H)；7.96(d,J=2.4Hz,1H)；IR(KBr):3393,2925,1610,1512,1295,1263,1240cm-1.
Ⅰb-308 mp175-177℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；2.00(s,6H)；4.58(d,J=6.0Hz,2H)；4.64(d,J=6.9Hz,2H)；4.98(brs,1H)；5.57(m,1H)；6.54(m,1H)；6.81-6.94(m,2H)；7.04(dt,J=1.8,8.4Hz,1H)；7.14(dd,J=1.8,5.1Hz,1H)；7.27(m,1H)；7.35(dd,J=3.0,4.8Hz,1H)；7.94(m,1H)；IR(KBr):3233,2912,1546,1512,1453,1420,1384,1317,1294,1259,1238,1204,1116cm-1.
Ⅰb-309 mp134-137℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.98(s,6H)；2.00(s,6H)；4.58(d,J=5.4Hz,2H)；4.64(d,J=6.6Hz,2H)；4.88(brt,1H)；5.57(m,1H)；6.30(dd,J=0.9,3.0Hz,1H),6.36(dd,J=4.2,6.3Hz,1H)；6.57(m,1H)；6.86(m,1H)；6.91(ddd,J=2.1,3.6,11.7Hz,1H)；7.03(dt,J=1.8,8.4Hz,1H)；7.28(m,1H)；7.40(m,1H)；7.94(m,1H)；IR(KBr):3379,2928,1513,1294,1263,1240cm-1.
Ⅰb-310 mp124-126℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.97(s,6H)；2.00(s,6H)；4.41(d,J=5.4Hz,2H)；4.64(d,J=6.3Hz,2H)；4.73(brt,1H)；5.57(m,1H)；6.47(m,1H),6.54(m,1H),6.82-7.08(m,3H),7.27(m,1H),7.43(t,J=1.8Hz,1H),7.46(m,1H)；7.94(d,J=2.4Hz,1H)；IR(KBr):3456,3236,2254,1605,1512,1468,1382,1293,1261,1240,1209,1114cm-1.
Ⅰb-311 mp143-145℃；1H NMR(CDCl3)δ1.78(s,3H)；1.82(s,3H)；1.97(s,6H)；2.00(s,6H)；4.64(d,J=7.0Hz,2H)；4.74(d,J=5.2Hz,2H)；5.58(m,1H)；5.76(m,1H),6.61(d,J=8.4Hz,1H)；6.82-7.29(m,4H)；7.40(d,J=8.0Hz,1H)；7.70(m,1H)；7.95(d,J=2.0Hz,1H)；8.61(d,J=4.8Hz,1H)；IR(KBr):3251,2929,1608,1514,1440,1380,1295,1264,1252,1240,1207cm-1.
Ⅰb-312 mp166-167℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；1.99(s,6H)；4.51(brs,2H)；4.64(d,J=6.6Hz,2H)；5.57(m,1H)；6.62(m,1H)；6.84(m,1H)；6.90(m,1H)；7.04(m,1H)；7.27(m,1H)；7.90(m,1H)；IR(KBr):3467,3304,3168,2917,1638,1619,1516,1388,1297,1265,1240,1209cm-1.
                          表120
Ⅰb-313 无定形；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),1.98(s,6H),2.01(s,6H),3.69(brs,1H),3.91(t,J=5.6Hz,2H),4.64(brs,1H),5.38(t,J=6.9Hz,1H),6.50(d,J=8.7Hz,1H),6.75-6.79(m,2H),6.92-6.97(m,2H),7.30(dd,J=8.7,2.1Hz,1H),7.91(d,J=2.1Hz,1H),7.56(dd,J=9.3,2.4Hz,1H)；IR(KBr):3447,3414,3364,1605,1518,1464,1377,1278,819cm-1
Ⅰb-314 mp172-173℃；1H NMR(CDCl3)δ1.75(s,6H),1.78(s,3H),1.78(s,3H),2.00(s,6H),2.01(s,6H),3.4(brs,1H),3.74(d,J=6.6Hz,2H),3.91(t,J=6.0Hz,2H),4.53(brs,1H),5.35-5.42(m,2H),6.49(dd,J=8.4,0.9Hz,1H),6.67-6.71(m,2H),6.94-7.00(m,2H),7.29(dd,J=8.4,2.4Hz,1H),7.93(dd,J=2.4,0.9Hz,1H)；IR(KBr):3415,3229,1606,1521,1465,1379,1315,1141,985,815cm-1
Ⅰb-315 mp207-209℃；1H NMR(CDCl3)δ1.76(s,3H),1.76(s,3H),1.96(s,6H),1.98(s,6H),3.4(brs,1H),3.88(d,J=7.8Hz,2H),5.42(t,J=7.8Hz,1H),6.76-6.82(m,2H),6.92-6.98(m,2H),7.26(d,J=7.8Hz,1H),7.34(dd,J=7.8,2.1Hz,1H),8.29(d,J=2.1Hz,1H)；IR(KBr):3452,3367,1619,1517,1457,1353,1280,1176,1107,820,540cm-1
Ⅰb-316 mp156-158℃；1H NMR(CDCl3)δ1.75(s,3H),1.76(s,3H),1.76(s,3H),1.78(s,3H),1.97(s,6H),2.00(s,6H),3.75(d,J=6.6Hz,2H),3.88(d,J=7.7Hz,2H),5.40(t,J=6.6Hz,2H),5.42(t,J=7.7Hz,1H),6.68-6.73(m,2H),6.93-7.00(m,2H),7.26(dd,J=8.1,1.1Hz,1H),7.34(dd,J=8.1,2.1Hz,1H),8.29(dd,J=2.1,1.1Hz,1H)；IR(KBr):3391,1612,1518,1462,1180,1108,820,807,546cm-1.
Ⅰb-317 mp161-164℃；1H NMR(CDCl3)δ1.77(s,3H),1.77(s,3H),1.99(s,6H),1.99(s,6H),2.11(s,6H),3.89(d,J=7.8Hz,2H),5.43(t,J=7.8Hz,1H),5.94(s,2H),7.21-7.39(m,6H),8.31(dd,J=2.3,0.8Hz,1H)；IR(KBr):3439,1586,1520,1449,1406,1110.999,824,750,565cm-1
Ⅰb-318 mp137-138℃,1H NMR(CDCl3)δ1.75(s,3H),1.78(s,6H),1.81(s,3H),1.82(s,3H),1.89(s,6H),1.98(s,6H),2.15(s,3H),3.75(d,J=6.9Hz,2H),4.86(d,J=7.2Hz,2H),5.40(m,1H),5.59(m,1H),6.64-6.71(m,3H),6.94-6.99(m,2H),7.26(d,J=8.4Hz,1H).IR(KBr):3412,2914,1611,1592,1460,1311,1297,1282,1237cm-1
Ⅰb-319 mp129-130℃,1H NMR(CDCl3)δ1.74(s,3H),1.79(s,6H),1.82(s,3H),1.98(s,6H),1.99(s,6H),2.25(s,3H),3.75(d,J=6.9Hz,2H),4.90(d,J=6.6Hz,2H),5.40(brt,J=6.9Hz,1H),5.59(brt,J=6.9Hz,1H),6.70(m,2H),6.97(m,2H),7.23(d,J=2.1Hz,1H),7.82(d,J=2.1Hz,1H)
Ⅰb-320 mp153-154℃,1H NMR(CDCl3)δ1.75(s,3H),1.79(s,6H),1.83(s,3H),1.89(s,6H),1.96(s,3H),1.99(s,6H),2.15(s,3H),3.75(d,J=6.9Hz,2H),4.86(d,J=6.9Hz,2H),5.40(m,1H),5.58(m,1H),6.69-6.73(m,3H),6.94-7.01(m,2H),7.84(s,1H).IR(KBr):3386,2928,1608,1518,1464,1377,1315,1180,1122,1028cm-1
Ⅰb-321 mp115-117℃；1H NMR(CDCl3)δ1.60(s,3H),1.73(s,3H),1.75(s,3H),1.78(s,3H),1.95(s,6H),2.01(s,6H),3.60(d,J=7.7Hz,2H),3.91(t,J=6.0Hz,2H),4.52(m,1H),5.32-5.42(m,2H),6.49(d,J=8.4Hz,1H),7.05-7.11(m,2H),7.28(dd,J=8.4,2.3Hz,1H),7.39-7.44(m,2H),7.91(d,J=2.3Hz,1H)；IR(KBr):3425,1609,1541,1391,1378,814,550cm-1
                                表121
Ⅰb-322 mp119-122℃；1H NMR(CDCl3)δ1.75(s,3H),1.77(s,3H),1.78(s,3H),1.82(s,3H),2.01(s,6H),2.03(s,3H),3.34(s,3H),3.91(dd,J=5.9,5.9Hz,2H),4.51(t,J=5.2Hz,1H),4.64(d,J=6.7Hz,2H),5.38(m,1H),5.57(m,1H),6.47(d,J=8.5Hz,1H),6.97-7.08(m,3H),7.23-7.28(m,1H),7.72(d,J=1.8Hz,1H)；IR(nujor):3325,1926,2853,1608,1538,1514,1457,1389,1296,1262,1214,1110,1006cm-1
Ⅰb-323 1H NMR(300MHz,CDCl3)δ1.80(d,J=0.9Hz,3H),1.83(d,J=0.9Hz,3H),1.98(s,6H),2.06(s,3H),3.32(s,3H),4.88(d,J=6.9Hz,2H),5.55-5.62(m,1H),6.80(d,J=7.8Hz,2H),6.85(dd,J=8.6,0.8Hz,1H),7.11(d,J=7.8Hz,2H),7.40(dd,J=8.6,2.6Hz,1H),7.98(dd,J=2.6,0.8Hz,1H)
Ⅰb-324 1H NMR(300MHz,CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(s,3H),1.83(s,3H),1.98(s,3H),2.07(s,3H),3.33(s,3H),3.75(d,J=6.6Hz,2H),4.88(d,J=6.9Hz,2H),5.36-5.43(m,1H),5.55-5.62(m,1H),6.71(d,J=8.0Hz,2H),6.84(dd,J=2.4,0.8Hz,1H),7.30(d,J=8.0Hz,2H),7.40(dd,J=8.6,2.4Hz,1H),7.98(dd,J=2.4,0.8Hz,1H)
Ⅰb-325 1H NMR(300MHz,CDCl3)δ1.80(s,3H),1.83(s,3H),1.97(s,6H),2.06(s,3H),3.32(s,3H),3.92(s,3H),4.46(s,2H),4.88(d,J=6.9Hz,2H),5.55-5.62(m,1H),6.71(d,J=8.0Hz,2H),6.84(d,J=8.4Hz,1H),7.12(d,J=8.0Hz,2H),7.40H,dd,J=8.4,2.2Hz,1H),7.50(d,J=8.1Hz,2H),7.98(d,J=2.2Hz,1H),8.04(d,J=8.1Hz,2H)
Ⅰb-326 1H NMR(300MHz,CDCl3)δ1.80(s,3H),1.83(s,3H),1.97(s,6H),2.06(s,3H),3.32(s,3H),4.48(s,2H),4.88(d,J=6.9Hz,2H),5.55-5.61(m,1H),6.70(d,J=7.8Hz,2H),6.85(d,J=8.4Hz,1H),7.12(d,J=7.8Hz,2H),7.40(dd,J=8.4,0.7Hz,1H),7.53(d,J=8.1Hz,2H),7.99(d,J=0.7Hz,1H),8.11(d,J=8.1Hz,2H)
Ⅰb-327 1H NMR(300MHz,CDCl3)δ1.80(s,3H),1.83(s,3H),1.98(s,3H),2.07(s,3H),3.32(s,3H),3.86(s,3H),3.87(s,6H),4.33(s,2H),4.88(s,J=6.6Hz,2H),5.55-5.60(m,1H),6.67(s,2H),6.76(d,J=7.1Hz,2H),6.85(dd,J=8.4,0.6Hz,1H),7.15(d,J=7.1Hz,2H),7.40(dd,J=8.4,2.4Hz,1H),7.98(dd,J=2.4,0.6Hz,1H)
Ⅰb-328 1H NMR(300MHz,CDCl3)δ1.80(s,3H),1.83(s,3H),1.97(s,6h),2.06(s,3H),3.31(s,3H),4.38(s,2H),4.88(d,J=7.2Hz,2H),5.55-5.62(m,1H),6.29(d,J=3.0Hz,1H),6.35(dd,J=3.0,1.8Hz,1H),6.77(d,d=8.1Hz,2H),6.84(dd,J=8.2,0.6Hz,1H),7.14(d,J=8.1Hz,2H),7.399(dd,J=1.8,0.8Hz,1H),7.40(dd,J=8.2,2.4Hz,1H),7.98(dd,J=2.4,0.6Hz,1H)
Ⅰb-329 mp110-111℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),1.98(s,6H),2.06(s,3H),3.33(s,3H),4.88(d,J=6.9Hz,2H),5.59(m,1H),6.79(d,J=8.7Hz.2H),6.84(dd,J=8.4和J=0.9Hz,1H),6.95(d,J=7.2Hz,2H),7.56(dd.J=8.4和2.7Hz,1H),8.11(dd,J=2.4和0.6Hz,1H)；IR(CHCl3):3462,3016,2934,1620,1604,1279,1241,1087,982,cm-1.
Ⅰb-330 mp115-116℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H)3.33(s,3H),3.75(d,J=6.6Hz,2H),4.88(d,J=6.9Hz,2H),5.39(m,1H),5.59(m,1H),6.71(d,J=7.8Hz,2H),6.84(dd,J=8.4和0.6Hz,1H),6.97(d,J=7.5Hz,2H),7.56(dd,J=8.4和2.4Hz,1H),8.11(dd,J=2.4和0.9Hz,1H)；IR(CHCl3)；3424,3004,2975,2934,2860,1612,1491,1402,1377,1280,1241,cm-1.
                                 表122
Ⅰb-331 mp111-112℃；1H NMR(CDCl3)δ1.26(s,3H),1.28(s,3H),1.79(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),3.68(m,1H),4.88(d,J=6.9Hz,2H),5.59(m,1H),6.67(d,J=8.4Hz,2H),6.84(dd,J=8.4和6.0Hz,1H),6.95(d,J=7.2Hz,2H),7.56(dd,J=8.4和2.4Hz,1H),8.12(dd,J=2.4和0.6Hz,1H)；IR(CHCl3):3423,3018,2975,2934,2872,1612,1354,1317,1377,1280,1242,cm-1.
Ⅰb-332 mp139-140℃；1H NMR(CDCl3)δ1.14-1.46(m 5H),1.65-1.80(m 3H),1.82(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),2.10-2.15(m,2H),3.30(m,1H),4.88(d,J=7.2Hz,2H),5.59(m,1H),6.87(d,J=8.7Hz,2H),6.84(dd,J=8.7和0.9Hz,1H),6.94(d,J=7.2Hz,2H),7.56(dd,J=8.7和2.7Hz,1H),8.11(dd,J=2.7和0.9Hz,1H)；IR(CHCl3):3422,3002,2933,2856,1612,1354,1318,1280,1242,1130,1087,cm-1.
Ⅰb-333 mp155-156℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),1.99(s,6H),2.06(s,3H),3.33(s,3H),4.38(s,2H),4.89(d,J=6.9Hz,2H),5.59(m,1H),6.30(m,1H),6.35-6.37(m,1H),6.77(d,J=8.4Hz,2H),6.83(dd,J=8.4和0.9Hz,1H),6.98(d,J=7.5Hz,2H),7.40(dd,J=2.1和0.9Hz,1H)7.57(dd,J=8.7和2.7Hz,1H)8.12(dd,J=2.4和0.6Hz,1H)；IR(CHCl3):3424,2934,2861,1613,1280,1241,1217,cm-1.
Ⅰb-334 mp142-145℃；1H NMR(CDCl3)δ1.99(s,3H),2.06(s,3H),3.33(s,3H),3.79(brs,2H),5.40(s,2H),6.40(dd,J=2.0,3.2Hz,1H),6.49(d,J=3.3Hz,1H),6.78(d,J=8.4Hz,2H),6.87(dd,J=0.8,8.3Hz,1H),6.95(brd,J=7.2Hz,2H),7.47(dd,J=0.9,1.5Hz,1H),7.58(dd,J=2.6,8.6Hz,1H),8.13(dd,J=0.8,2.6Hz,1H)；IR(nujor):3342,2924,2854,1611,1523,1493,1458,1283,1011,824cm-1
Ⅰb-335 mp158-159℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),4.38(s,2H),4.89(d,J=7.0Hz,2H),5.59(m,1H),6.74(d,J=8.6Hz,2H),6.84(dd,J=0.7,8.4Hz,1H),6.98(brd,J=6.9Hz,2H),7.28-7.46(m,5H),7.56(dd,J=2.5,8.5Hz,1H),8.12(dd,J=0.7,2.3Hz,1H),IR(nujor):3357,2926,2854,1613,1526,1491,1452,1279,1090,997,823,732cm-1
Ⅰb-336 mp116-117℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H),2.30(s,3H),3.33(s,3H),4.31(s,2H),4.88(d,J=6.9Hz,2H),5.59(m,1H),5.93(m,1H),6.17(d,J=3.1Hz,1H),6.76(d,J=8.6Hz,2H),6.84(d,J=8.5Hz,1H),6.98(brd,J=6.7Hz,2H),7.56(dd,J=2.3,8.5Hz,1H),8.12(d,J=2.3Hz,1H),IR(nujor):3349,2925,2854,1611,1525,1490,1455,1280,1240,979,822,782cm-1
Ⅰb-337 mp94-97℃；1H NMR(CDCl3)δ1.66(brd,J=6.7Hz,3H),1.73(s,3H),1.80(s,3H),1.83(s,3H),1.99(s,6H),2.06(s,3H),3.33(s,3H),3.69(brs,2H),4.88(d,J=6.9Hz,2H),5.52-5.62(m,2H),6.70(d,J=8.6Hz,2H),6.83(dd,J=0.7,8.4Hz,1H),6.95(brd,J=7.4Hz,2H),7.56(dd,J=2.5,8.5Hz,1H),8.11(dd,J=0.7,2.3Hz,1H),IR(KBr):3409,3325,2927,2857,1612,1523,1457,1279,1085,1002,986,820cm-1
Ⅰb-338 mp161-163℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),3.86(s,3H),3.87(s,6H),4.42(s,2H),4.88(d,J=7.0Hz,2H),5.59(m,1H),6.66(s,2H),6.75(d,J=8.6Hz,2H),6.84(dd,J=0.6,8.5Hz,1H),6.99(brd,J=6.7Hz,2H),7.56(dd,J=2.4,8.4Hz,1H),8.12(dd,J=0.6,2.3Hz,1H),IR(KBr):3373,2934,2831,1604,1592,1522,1457,1280,1240,1124,981,822cm-1
                          表123
Ⅰb-339 mp113-115℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(d,J=0.9Hz,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),3.76(d,J=6.7Hz,2H),4.83(dd,J=5.3Hz,2H),5.39(m,1H),5.78-5.96(m,2H),6.70(d,J=8.6Hz,2H),6.84(dd,J=0.7,8.5Hz,1H),6.97(brd,J=7.3Hz,2H),7.57(dd,J=2.4,8.4Hz,1H),8.11(dd,J=0.7,2.5Hz,1H)；IR(nujor):3367,2924,2853,1611,1520,1457,1278,1241,992,820cm-1
Ⅰb-340 mp90-92℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),2.00(s,6H),2.06(s,3H),2.59(dt,J=6.7,6.7Hz),3.33(s,3H),3.75(d,J=6.9Hz,2H),4.42(t,J=6.8Hz,2H),5.12(brd,J=10.2Hz,1H),5.20(ddt,J=1.6,1.6,17.2Hz,1H),5.39(m,1H),5.96(ddt,J=6.7,10.3,17.1Hz,1H),6.70(d,J=8.6Hz,2H),6.83(dd,J=0.7,8.4Hz,1H),6.96(brd,J=6.9Hz,2H),7.57(dd,J=2.3,8.5Hz,1H),8.11(dd,J=0.7,2.4Hz,1H)；IR(nujor):3362,2952,2925,2854,1611,1604,1519,1466,1280,819cm-1
Ⅰb-341 mp97-98；1H NMR(CDCl3)δ1.04(t,J=7.5Hz,3H),1.75(s,3H),1.78(s,3H),2.00(s,6H),2.06(s,3H),2.22(dq,J=7.0,7.1Hz,2H),3.33(s,3H),3.75(d,J=6.9Hz,2H),4.95(d,J=5.3Hz,2H),5.39(m,1H),5.71(dt,J=6.1,11.0Hz,1H),5.75(dt,J=6.1,10.8Hz,1H),6.70(d,J=8.8Hz,2H),6.84(dd,J=0.7,8.5Hz,1H),6.97(brd,J=6.9Hz,2H),7.57(dd,J=2.4,8.4Hz,1H),8.12(dd,J=0.7,2.5Hz,1H),IR(KBr):3341,2965,2930,1612,1523,1491,1456,1281,1243,1089,991,822cm-1
Ⅰb-342 mp129-180℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1,92(t,J=2.1Hz 3H),2.00(s,6H),2.05(s,3H),3.32(s,3H),3.75(d,J=6.6Hz,2H),5.02(m,2H),5.40(m,1H),6.72(d,J=8.4Hz,2H),6.89(dd,J=8.4和0.6Hz,1H),6.97(d,J=7.2Hz,2H),7.59(dd,J=8.4和2.4Hz,1H),8.12(dd,J=2.4和0.6Hz,1H)；IR(CHCl3):3424,3004,2933,2858,1612,1346,1279,1241,cm-1.
Ⅰb-343 mp137-138℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),2.00(s,6H),2.06(s,3H),3.33(s,3H),3.75(d,J=6.9Hz,2H),5.40(m,3H),6.40(dd,J=3.3和1.8Hz,1H),6.49(d,J=3.3Hz,1H),6.70(d,J=8.7Hz,2H),6.87(dd,J=9.0和0.6Hz,1H),6.97(d,J=7.5Hz,2H),7.47(dd,J=1.8和0.9Hz,1H),7.59(dd,J=8.4和2.4Hz,1H),8.13(dd,J=2.4和0.6Hz,1H)；IR(CHCl3):3424,3004,2933,2860,1612,1402,1453,1346,1280,cm-1.
Ⅰb-344 mp144-146℃；1H NMR(CDCl3)δ1.80(s,3H),1.84(s,3H),1.85(t,J=2.4Hz,3H),2.00(s,6H),2.07(s,3H),3.34(s,3H),3.94(q,J=2.4Hz,2H),4.89(d,J=6.9Hz,2H),5.60(m,1H),6.76(d,J=8.4Hz,2H),6.85(d,J=8.4Hz,1H),7.00(brd,J=7.5Hz,2H),7.57(dd,J=2.4,8.4Hz,1H),8.13(d,J=2.4Hz,1H)；IR(CHCl3):3451,3395,3024,3015,2934,1621,1604,1518,1491,1280,993,825cm-1
Ⅰb-345 mp113-115℃；1H NMR(CDCl3)δ1.75(s,3H),1.77(s,3H),2.00(s,6H),2.05(s,3H),3.32(s,3H),3.75(d,J=6.7Hz,2H),4.64(dd,J=3.9,29.2Hz,1H),4.66(dd,J=2.9,29.2Hz,1H),4.81(dd,J=3.0,47.5Hz,1H),4.82(dd,J=3.9,47.4Hz,1H),5.40(m,1H),6.70(d,J=8.6Hz,2H),6.90(dd,J=0.7,8.4Hz,1H),6.96(brd,J=7.5Hz,2H),7.59(dd,J=2.4,8.4Hz,1H),8.09(dd,J=0.7,2.5Hz,1H)；IR(nujor):3399,2925,2854,1612,1519,1491,1450,1283,1087,929cm-1
                        表124
Ⅰb-346 mp111-112℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),2.00(s,6H),2.05(s,3H),3.32(s,3H),3.75(d,J=6.9Hz,2H),4.82(dq,J=1.4,8.6Hz,2H),5.39(m,1H),6.70(d,J=8.7Hz,2H),6.93-6.97(m,3H),7.64(dd,J=2.4,8.4Hz,1H),8.10(dd,J=0.3,2.1Hz,1H),IR(KBr):3407,2931,2860,1613,1521,1292,1274,1259,1240,1164,1070,823cm-1
Ⅰb-347 mp154-156℃；1H NMR(CDCl3)δ1.85(t,J=2.6Hz,3H),1.99(s,6H),2.06(s,3H),3.33(s,3H),3.93(q,J=2.4Hz,2H),5.40(s,2H),6.40(dd,J=1.7,3.2Hz,1H),6.49(dd,J=0.9,3.0Hz,1H),6.76(d,J=8.7Hz,2H),6.87(dd,J=0.9,8.7Hz,1H),6.99(brd,J=7.5Hz,2H),7.48(dd,J=0.9,1.8Hz,1H),7.58(dd,J=2.6,8.6Hz,1H),8.14(dd,J=0.6,2.4Hz,1H),IR(KBr):3410,2989,2934,2860,1610,1520,1278,1242,992,822,742cm-1
Ⅰb-348 mp165-168℃；1H NMR(CDCl3)δ1.85(t,J=2.4Hz,3H),1.91(t,J=2.4Hz,3H),1.99(s,6H),2.05(s,3H),3.32(s,3H),3.93(q,J=2.4Hz,2H),5.01(q,J=2.4Hz,2H),6.76(d,J=8.7Hz,2H),6.89(dd,J=0.8,8.6Hz,1H),6.99(brd,J=7.2Hz,2H),7.58(dd,J=2.4,8.4Hz,1H),8.12(dd,J=0.6,2.4Hz,1H),IR(KBr):3393,3338,2923,2862,2237,1612,1604,1521,1279,1243,996,824cm-1
Ⅰb-349 mp172-173℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),2.05(s,3H),2.30(s,6H),2.63(s,3H),3.32(s,3H),2.30(s,6H),3.74(d,J=6.6Hz,2H),5.39(m,1H),6.70(d,J=8.7Hz,2H),6.96(d,J=6.6Hz,2H),7.27(dd,J=8.4和0.6Hz,1H),7.51(dd,J=8.1 and 2.1Hz,1H),7.42(dd,J=2.1和0.9Hz,1H),；IR(CHCl3):3423,3003,2931,28598,1613,1589,1315,14021,1289,cm-1.
Ⅰb-350 mp183-184℃；1H NMR(CDCl3)δ1.75(s,3H),1.79(s,3H),2.01(s,6H),2.03(s,3H),3.32(s,3H),3.33(s,3H),3.75(d,J=69Hz,2H),5.40(m,1H),6.72(d,J=8.7Hz,2H),6.75(d,J=8.1Hz,2H),7.98(dd,J=8.1和2.1Hz,1H),8.17(dd,J=8.1和0.9Hz,1H),8.70(dd,J=2.7和0.6Hz,1H),；IR(CHCl3):3424,3016,2934,2860,1613,1315,1292,1231,cm-1.
Ⅰb-351 mp148-149℃；1H NMR(CDCl3)δ1.79(s,3H),1.83(s,3H),2.05(s,3H),2.06(s,3H),3.33(s,3H),3.34(s,3H),4.88(d,J=6.9Hz,2H),5.58(m,1H),6.78(d,J=8.7Hz,2H),6.84(d,J=8.4Hz,1H),7.11(d,J=8.7Hz,2H),7.56(dd,J=8.4,2.4Hz,1H),8.12(d,J=2.4Hz,1H)IR(KBr):3393,1603,1520,1492,1459,1399,1373,1357,1282,1247,1128,1038,1020,982,824cm-1
Ⅰb-352 mp106-107℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),1.80(s,3H),1.83(s,3H),2.07(s,3H),2.08(s,3H),3.33(s,3H),3.34(s,3H),3.75(d,J=6.6Hz,2H),4.88(d,J=7.2Hz,2H),5.38(m,1H),5.58(m,1H),6.70(d,J=8.4Hz,2H),6.84(d,J=8.4Hz,1H),7.12(d,J=8.4Hz,2H),7.56(dd,J=8.4,2.4Hz,1H),8.12(d,J=2.4Hz,1H)IR(KBr):3401,1614,1603,1561,1522,1491,1463,1281,1242,1182,1128,1037,985,821cm-1
Ⅰb-353 mp126-127℃；1H NMR(CDCl3)δ1.49(s,3H),1.67(s,3H),1.80(s,3H),1.83(s,3H),2.02(s,3H),2.07(s,3H),2.81(d,J=5.4Hz,3H),3.30(s,3H),3.34(s,3H),4.17(q,J=5.4Hz,2H),4.27(d,J=7.2Hz,2H),4.89(d,J=7.2Hz,2H),5.29(m,1H),5.58(m,1H),6.85(d,J=8.4Hz,1H),7.32(d,J=4.2Hz,2H),7.44(d,J=4.2Hz,2H),7.59(dd,J=8.4,2.4Hz,1H),8.11(d,J=2.4Hz,1H)IR(KBr):3304,1603,1564,1512,1491,1455,1355,1329,1279,1149,1131,1043,1019,986,879,823,583cm-1
                         表125
Ⅰb-354 mp117-118℃；1H NMR(300MHz,CDCl3)δ1.12-1.30(m,2H),1.30-1.48(m,2H),1.62-1.75(m,2H),1.80(s,3H),1.83(s,3H),1.75-1.84(m,2H),2.06(s,3H),2.07(s,3H),2.06-2.18(m,2H),3.33(s,3H),3.34(s,3H),3.30-3.37(m,1H),4.88(d,J=6.9Hz,2H),5.56-5.61(m,1H),6.65-6.72(m,2H),6.84(dd,J=8.7,0.9Hz,1H),7.06-7.13(m,2H),7.56(dd,J=8.7,2.4Hz,1H),8.11(dd.J=2.4,0.9Hz,1H).
Ⅰb-355 mp108-110℃,1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.81(s,3H),1.82(s,3),1.94(s,3H),2.06(s,3H),2.26(s,3H),3.32(s,3H),3.33(s,3H),3.75(d,J=6.9Hz,2H),4.87(d,J=7.2Hz,2H),5.40(m,1H),5.57(m,1H),6.65(d,J=8.4Hz,2H),6.72(d,J=8.4Hz,2H),7.14(d,J=8.4Hz,2H),7.37(d,J=8.4Hz,1H).IR(KBr):3417,2930,1613,1595,1520,1449,1391,1297,1281,1246,1133,1101,1038cm-1
Ⅰb-356 mp119-121℃,1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.79(s,3H),1.82(s,3H),2.06(s,3H),2.07(s,3H),2.25(s,3H),3.33(s,3H),3.35(s,3H),3.75(d,J=6.6Hz,2H),4.91(d,J=6.6Hz,2H),5.39(brt,J=6.6Hz,1H),5.59(brt,J=6.6Hz,1H),6.71(d,J=8.4Hz,2H),7.13(d,J=8.4Hz,2H),7.37(d,J=2.1Hz,1H),7.94(d,J=2.1Hz,1H)
Ⅰb-357 mp130-132℃,1H NMR(CDCl3)δ1.74(s,3H),1.79(s,6H),1.82(s,3H),1.94(s,3H),2.06(s,6H),3.33(s,3H),3.37(s,3H),3.76(d,J=6.9Hz,2H),4.86(d,J=6.9Hz,2H),5.40(m,1H),5.57(m,1H),6.71-6.74(m,3H),7.14(d,J=8.7Hz,2H),7.94(s,1H).IR(KBr):3392,2927,1611,1521,1448,1390,1349,1322,1286,1270,1236,1179,1115,1026cm-1
Ⅰb-358 mp120-121℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),2.06(s,3H),2.07(s,3H),2.63(s,3H),3.33(s,6H),3.75(d,J=9.6Hz,2H),5.39(m,1H),6.70(d,J=8.4Hz,2H),7.12(d,J=8.4Hz,2H),7.27(d,J=8.1Hz,1H),7.51(dd,J=8.1,2.4Hz,1H),8.42(d,J=2.4Hz,1H)IR(KBr):3379,1614,1587,1523,1459,1395,1351,1319,1286,1136,1109,1038,1016,985,818cm-1
Ⅰb-359 mp163-164℃；1H NMR(300MHz,CDCl3)δ1.75(s,3H),1.78(s,3H),2.07(s,3H),2.09(s,3H),3.33(s,3H),3.36(s,3H),3.75(d,J=6.6Hz,2H),3.91(t,J=5.9Hz,2H),4.58(brs,1H),5.35-5.42(m,2H),6.49(d,J=8.3Hz,1H),6.65-6.72(m,2H),7.08-7.15(m,2H),7.44(dd,J=8.3,2.0Hz,1H),8.06(d,J=2.0Hz,1H).
Ⅰb-360 mp145-146℃；1H NMR(300MHz,CDCl3)δ1.79(s,3H),2.06(s,3H).2.08(s,3H),3.35(s,3H),3.78(t,J=5.6Hz,2H),3.88(brs,1H),4.53(brs),5.36-5.44(m,1H),6.61(dd,J=8.4,0.75Hz,1H),6.73-6.79(m,1H),6.92-6.98(m,2H),7.45(dd,J=8.4,2.1Hz,1H),8.04(d,J=2.1Hz,1H).
Ⅰb-361 mp143-144℃；1H NMR(300MHz,CDCl3)δ1.75(s,3H),1.79(s,3H),2.06(s,3H),2.09(s,3H),3.35(s,3H),3.36(s,3H),3.78(t,J=6.0Hz,2H),3.83-3.94(m,3H),4.53(brs,1H),5.34-5.44(m,2H),6.48(dd,J=8.4,0.9Hz,1H),6.73-6.79(m,1H),6.92-6.98(m,2H),7.43(dd,J=8.4,2.4Hz,1H),8.05(dd,J=2,4,0.6Hz,1H).
Ⅰb-362 1H NMR(300MHz,CDCl3)δ1.20-1.35(m,3H),1.35-1.48(m,2H),1.77(s,3H),1.82(s,3H),1.60-1.96(m,3H),2.04(s,3H),2.09(s,3H),2.04-2.15(m,2H),3.34(s,3H),3.36(s,3H),3.53-3.64(m,1H),4.64(d,J=6.9Hz,2H),4.60-4.65(m,1H),5.54-5.60(m,1H),6.47(d,J=8.4Hz,1H),6.96-7.09(m,3H),7.41(dd,J=8.4,2.2Hz,1H),8.02(d,J=2.2Hz,1H).
                            表126
Ⅰb-363 mp96-97℃；1HNMR(CDCl3)δ1.74(s,3H),1.79(s,6H),1.82(s,3H),2.05(s,6H),2.18(s,3H),3.74(d,J=6.6Hz,2H),4.87(d,J=7.2Hz,2H),5.39(t,J=6.9Hz,1H),5.58(t,J=7.2Hz,1H),6.70(d,J=8.4Hz,2H),6.81(d,J=8.4Hz,1H),6.96-6.99(m,3H),7.57(dd,J=0.9,8.7Hz,1H),8.16(d,J=2.1Hz,1H)；IR(KBr):3345,2972,2913,1613,1560,1522,1490,1466,1281,1240,982,827cm-1
Ⅰb-364 mp133-134℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.05(s,6H),2.18(s,3H),4.17(brs,1H),4.38(s,2H),4.87(d,J=7.2Hz,2H),5.58(t,J=7.2Hz,1H),6.74(d,J=8.4Hz,2H),6.81(dd,J=0.6,8.4Hz,1H),6.97-6.99(m,3H),7.31-7.46(m,5H),7.57(dd,J=2.7,8.7Hz,1H),8.15(dd,J=0.6,2.4Hz,1H)；IR(KBr):3357,2962,2922,1614,1526,1491,1465,1359,1280,1241,999,828cm-1
Ⅰb-365 mp89-91℃；1H NMR(CDCl3)δ1.71(s,3H),1.75(s,3H),1.79(s,3H),1.82(s,3H),2.25(s,3H),3.75(d,J=6.9Hz,2H),3.88(s,3H),4.87(d,J=6.9Hz,2H),5.37(m,1H),5.58(m,1H),6.74-6.84(m,4H),7.21(s,1H),7.41-7.45(m,2H),7.76(dd,J=2.4,8.4Hz,1H),8.19(d,J=2.4Hz,1H)；IR(CHCl3):3426,2935,2859,1611,1524,1504,1482,1379,1357,1316,1281,1241,1187,1165,1128,1039,979,895cm-1
Ⅰb-366 mp93-94℃；1H NMR(CDCl3)δ1.25(d,J=6.3Hz,6H),1.79(s,3H),1.82(s,3H),2.24(s,3H),3.67(m,1H),3.79(s,3H),4.87(d,J=7.2Hz,2H),5.57(m,1H),6.69(d,J=7.5Hz,2H),6.79(s,1H),6.82(d,J=8.4Hz,1H),7.21(s,1H),7.42(d,J=8.4Hz,2H),7.60(dd,J=2.4,8.7Hz,1H),8.19(d,J=2.4Hz,1H)；IR(CHCl3):3424,2974,2934,2871,1673,1611,1566,1524,1504,1482,1385,1357,1318,1281,1242,1129,1039,979cm-1
Ⅰb-367 mp105-108℃；1H NMR(CDCl3)δ1.79(s,3H),1.82(s,3H),2.24(s,3H),3.78(s,3H),4.38(s,2H),4.87(d,J=7.2Hz,2H),5.57(m,1H),6.73(d,J=8.4Hz,2H),6.79(s,1H),6.82(d,J=8.4Hz,1H),7.20(s,1H),7.28-7.43(m,7H),7.60(dd,J=2.4,8.4Hz,1H),8.18(d,J=2.4Hz,1H)；IR(CHCl3):3448,3421,2936,2859,1612,1566,1524,1482,1391,1358,1316,1281,1242,1187,1165,1128,1039,979cm-1
Ⅰb-368 mp112-113℃；1H NMR(CDCl3)δ1.55-1.72(m,6H),1.79(s,3H),1.82(s,3H),2.07-2.12(m,2H),2.24(s,3H),3.41(m,1),3.79(s,3H),3.96(s,4H),4.87(d,J=6.6Hz,2H),5.57(m,1H),6.70-6.83(m,4H),7.20(s,1H),7.42(d,J=8.4Hz,2H),7.42(d,J=8.4Hz,2H),7.60(dd,J=1.8,8.4Hz,1H),8.18(d,J=1.8Hz,1H)；IR(CHCl3):3425,2952,2887,1611,1524,1504,1482,1445,1376,1357,1310,1281,1188,1152,1105,1036,977,925cm-1
Ⅰb-369 mp141-142℃；1H NMR(CDCl3)δ1.56(m,2H),1.79(s,3H),1.82(s,3H),2.05-2.10(m,2H),2.25(s,3H),3.48-3.59(m,3H),3.79(s,3H),4.00-4.05(m,2H),4.87(d,J=6.9Hz,2H),5.57(m,1H),6.73-6.84(m,4H),7.20(s,1H),7.42(d,J=8.4Hz,2H),7.60(dd,J=2.4,8.4Hz,1H),8.18(d,J=2.4Hz,1H)；IR(CHCl3):3424,2966,2939,2850,1611,1566,1523,1482,1386,1357,1316,1188,1136,1087,1039,982,870cm-1
Ⅰb-370 mp83-86℃；1H NMR(CDCl3)δ1.71(s,3H),1.75(s,3H),2.24(s,3H),3.74-3.81(m,5H),5.35-5.40(m,3H),6.40(m,1H),6.48(m,1H),6.74(d,J=8.7Hz,2H),6.80(s,1H),6.85(d,J=8.7Hz,1H),7.21(s,1H),7.42-7.48(m,3H),7.62(dd,J=2.4,8.4Hz,1H),8.20(d,J=2.4Hz,1H)；IR(CHCl3):3427,2935,2858,1611,1567,1524,1503,1480,1390,1346,1316,1282,1187,1165,1150,1127,1039,1015,992,920cm-1
                          表127
Ⅰb-371 mp100-101℃；1H NMR(CDCl3)δ1.26(d,J=6.3Hz,6H),2.24(s,3H),3.67(m,1H),3.79(s,3H),5.39(s,2H),6.40(m,1H),6.49(m,1H),6.70-6.73(m,2H),6.79(s,1H),6.84(d,J=8.4Hz,1H),7.21(s,1H),7.43(d,J=8.4Hz,2H),7.48(m,1H),7.62(dd,J=2.4,8.4Hz,1H),8.20(d,J=2.4Hz,1H)；IR(CHCl3):3424,2967,2934,1611,1567,1524,1479,1384,1346,1318,1282,1243,1187,1151,1127,1039,1015,992,920cm-1
Ⅰb-372 mp138-139℃；1H NMR(CDCl3)δ1.56-1.84(m,6H),2.09-2.12(m,2H),2.24(s,3H),3.42(m,1H),3.79(s,3H),3.97(s,4H),5.39(s,2H),6.40(m,1H),6.49(d,J=3.3Hz,1H),6.72(m,2H),6.79(s,1H),6.85(d,J=8.7Hz,1H),7.20(s,1H),7.42(d,J=8.7Hz,2H),7.47(d,J=1.8Hz,1H),7.62(dd,J=2.7,8.7Hz,1H),8.20(d,J=2.7Hz,1H)；IR(CHCl3):3425,2952,2886,1611,1568,1524,1504,1480,1446,1375,1346,1311,1282,1188,1151,1105,1037,993,924cm-1
Ⅰb-373 mp128-130℃；1H NMR(CDCl3)δ1.73(s,3H),1.78(s,3H),1.79(s,3H),1.82(s,3H),2.04(s,3H),2.08(s,3H),3.34(s,3H),3.54(s,3H),3.75(d,J=6.3Hz,2H),4.86(d,J=6.9Hz,2H),5.39(m,H),5.56(m,1H),6.72(d,J=8.4Hz,2H),6.79(dd,J=8.7,0.6Hz,1H),7.11(d,J=8.4Hz,2H),7.48(dd,J=8.7,2.4Hz,1H),8.04(dd,J=2.4,0.6Hz,1H)；IR(KBr)3420,1730,1612,1603,1561,1521,1490,1461,1277,1223,1120,1002,983,823cm-1
Ⅰb-374 mp172-173℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),2.04(s,3H),2.08(s,3H),3.35(s,3H),3.53(s,3H),3.75(d,J=6.9Hz,2H),5.38(s,2H),5.39(m,1H),6.39(dd,J=3.3,1.8Hz,1H),6.48(d,J=3.3Hz,1H),6.73(d,J=8.4Hz,2H),6.82(dd,J=8.4,0.9Hz,1H),7.11(d,J=8.4Hz,2H),7.47(dd,J=1.8,0.9Hz,1H)7.50(dd,J=8.4,2.4Hz,1H),8.06(dd,J=2.4,0.9Hz,1H)；IR(KBr)3415,1730,1610,1562,1520,1490,1452,1346,1278,1224,1121,989,825,736cm-1
Ⅰb-375 mp146-147℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),1.79(s,3H),1.83(s,3H),1.99(s,6H),2.02(s,3H),2.12(s,3H),3.75(d,J=6.9Hz,2H),3.80(brs,1H),4.89(d,J=6.9Hz,2H),5.39(t,J=6.9Hz,1H),5.59(t,J=7.2Hz,1H),6.70(d,J=8.7Hz,2H),6.85(d,J=8.4Hz,1H),6.91-6.99(m,2H),7.45(dd,J=2.4,8.4Hz,1H),8.01(dd,J=0.9,2.1Hz,1H)；IR(KBr):3395,2970,2911,2855,1613,1603,1519,1376,1277,1185,1126,977,804cm-1
Ⅰb-376 mp187-188℃；1H NMR(CDCl3)δ1.79(s,3H),1.83(s,3H),1.99(s,3H),2.02(s,3H),2.12(s,3H),4.13(brs,1H),4.38(s,2H),4.89(d,J=6.9Hz,2H),5.59(t,J=7.2Hz,1H),6.74(d,J=8.4Hz,2H),6.85(d,J=8.4Hz,1H),6.93-6.96(m,2H),7.31-7.46(m,6H),8.01(d,J=1.8Hz,1H)；IR(KBr):3358,2964,2929,1613,1526,1490,1451,1280,1244,1184,1125,997,975,804,732cm-1
Ⅰb-377 mp75-76℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),1.80(s,3H),1.83(s,3H),2.01(s,3H),2.07(s,3H),2.11(s,3H),3.37(s,3H),3.73(d,J=6.6Hz,2H),4.09(brs,1H),4.88(d,J=6.9Hz,2H),5.38(t,J=6.6Hz,1H),5.59(t,J=7.2Hz,1H),6.52-6.56(m,2H),6.84(d,J=7.5Hz,1H),6.85(s,1H),6.96(d,J=7.8Hz,1H),7.59(dd,J=2.4,8.4Hz,1H),8.14(d,J=1.8Hz,1H)；IR(KBr):3424,3339,2969,2927,1611,1509,1460,1353,1282,1252,1103,984,813cm-1
                            表128
Ⅰb-378 mp150-151℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),2.01(s,3H),2.06(s,3H),2.11(s,3H),3.37(s,3H),4.36(s,2H),4.88(d,J=6.9Hz,2H),5.59(t,J=7.2Hz,1H),6.54-6.60(m,2H),6.84(d,J=8.4Hz,1H),6.84(s,1H),6.96(d,J=8.1Hz,1H),7.30-7.44(m,5H),7.58(dd,J=2.4,8.4Hz,1H),8.14(dd,J=0.9,2.4Hz,1H)；IR(KBr):3412,3272,3018,2927,2858,1611,1517,1459,1375,1355,1317,1283,1243,1106,1050,985cm-1
Ⅰb-379 mp69-70℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(s,3H),1.83(s,3H),2.13(s,3H),2.15(s,3H),3.38(s,3H),3.72(d,J=6.9Hz,2H),4.88(d,J=6.9Hz,2H),5.36(t,J=6.9Hz,1H),5.58(t,J=7.2Hz,1H),6.38-6.49(m,2H),6.84(d,J=8.4Hz,1H),6.95(s,1H),7.06(dd,J=8.1,8.4Hz,1H),7.57(dd,J=2.4,8.4Hz,1H),8.13(d,J=1.8Hz,1H)；IR(KBr):3416,2972,2930,1627,1522,1462,1376,1269,1240,1171,1098,963,832cm-1
Ⅰb-380 mp156-157℃；1H NMR(CDCl3)δ1.80(s,3H),1.83(s,3H),2.13(s,3H),2.14(s,3H),3.38(s,3H),4.36(s,2H),4.89(d,J=7.2Hz,2H),5.58(t,J=7.2Hz,1H),6.40-6.51(m,2H),6.84(d,J=8.4Hz,1H),6.94(s,1H),7.09(dd,J=8.1,8.4Hz,1H),7.32-7.40(m,5H),7.58(dd,J=2.4,8.4Hz,1H),8.13(dd,J=0.6,1.8Hz,1H)；IR(KBr):3262,3019,2930,1626,1528,1464,1353,1317,1284,1244,1170,1105,986,821cm-1
Ⅰb-381 mp121-123℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.80(s,6H),1.83(s,3H),1.97(s,3H),2.00(s,3H),2.07(s,3H),3.51(s,3H),3.72(d,J=6.9Hz,2H),4.88(d,J=6.9Hz,2H),5.37(m,1H),5.58(m,1H),6.64(d,J=8.7Hz,2H),6.85(d,J=8.4Hz,1H),7.01-7.08(m,2H),7.38(dd,J=8.4,2.4Hz,1H),7.96(d,J=2.4Hz,1H)；IR(KBr)3391,1713,1613,1602,1524,1487,1437,1298,1276,1243,1222,1122,979cm-1
Ⅰb-382 mp126-128℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.97(s,3H),2.00(s,3H),2.07(s,3H),3.51(s,3H),3.72(d,J=6.6Hz,2H),5.37(m,1H),5.39(s,2H),6.41(dd,J=3.0,1.8Hz,1H),6.50(brd,J=3.0Hz,1H),6.64(d,J=8.7Hz,2H),6.89(dd,J=8.4,0.6Hz,1H),7.01-7.09(m,2H),7.40(dd,J=8.4,2.4Hz,1H),7.48(dd,J=1.8,0.6Hz,1H),7.98(dd,J=2.4,0.6Hz,1H)；IR(KBr)8384,1714,1612,1523,1490,1343,1322,1301,1281,1246,1224,1124,990cm-1
Ⅰb-383 mp161-163℃；1H NMR(CDCl3)δ1.73(s,3H),1.77(s,3H),1.91(t,J=2.4Hz,3H),1.96(s,3H),1.99(s,3H),2.07(s,3H),3.51(s,3H),3.72(d,J=6.6Hz,2H),5.01(q,J=2.4Hz,2H),5.37(m,1H),6.65(d,J=9.0Hz,2H),6.90(dd,J=8.7,0.9Hz,1H),7.01-7.08(m,2H),7.40(dd,J=8.7,2.4Hz,1H),7.97(dd,J=2.4,0.9Hz,1H)；IR(KBr)3385,1725,1613,1603,1525,1488,1344,1329,1303,1281,1246,1221,999cm-1
Ⅰb-384 Oil 1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.30(s,3H),2.44(s,3H),4.64(d,J=6.6Hz,2H),5.55(m,1H),6.99-7.12(m,3H),7.17(s,1H),7.37(s,1H),7.53(d,J=1.2Hz,1H),9.07(d,J=1.2Hz,1H)
Ⅰb-385 mp93-94℃；1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.28(s,3H),2.40(s,3H),4.05(s,3H),4.64(d,J=6.9Hz,2H),5.55(m,1H),6.86(d,J=1.2Hz,1H),6.98-7.12(m,3H),7.26(s,1H),7.34(s,1H),8.87(d,J=1.2Hz,1H)；IR(KBr)1589,1533,1518,1496,1394,1364,1299,1263,1232,1123,1040,997,986,872cm-1
                          表129
Ⅰb-386 mp95-96℃；1HNMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.28(s,3H),2.38(s,3H),3.17(s,6H),4.64(d,J=6.9Hz,2H),5.55(m,1H),6.53(d,J=1.2Hz,1H),6.98-7.14(m,4H),7.29(s,1H),8.69(d,J=1.2Hz,1H)；IR(KBr)1591,1512,1417,1405,1299,1278,1261,1228,1123,1000,836,827cm-1
Ⅰb-387 mp88-90℃；1H NMR(CDCl3)δ1.78(s,3H),1.83(s,3H),2.29(s,3H),2.30(s,3H),4.57(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.99(d,J=8.4Hz,2H),7.12(s,1H),7.20(s,1H),7.28(d,J=8.4Hz,2H),8.79(s,2H),9.22(s,1H)；IR(KBr)1611,1519,1497,1415,1384,1240,1007,820,731cm-1.
Ⅰb-388 mp97-98℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.29(s,3H),2.30(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),7.00-7.14(m,4H),7.18(s,1H),8.78(s,2H),9.22(s 1H)；IR(KBr)1523,1502,1415,1386,1313,1285,1274,1263,1233,1200,1131,995,858cm-1.
Ⅰb-389 mp163-166℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),4.56(d,J=6.6Hz,2H),5.11(tm,J=6.6Hz,1H),6.98(d,J=8.7Hz,2H),7.08(s,1H),7.16(s,1H),7.27(d,J=8.7Hz,2H),8.35(s,2H)；IR(KBr)3393,3315,3196,1639,1605,1595,1518,1480,1236,1002,838,802cm-1.
Ⅰb-390 mp158-160℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.28(s,3H),2.29(s,3H),4.64(d,J=6.6Hz,2H),5.17(s,2H),5.56(t,J=6.6Hz,1H),6.98-7.16(m,5H),8.35(s,2H)；IR(KBr)3334,3187,1655,1598,1522,1486,1296,1269,1230,1125,998cm-1.
Ⅰb-391 mp156-158℃；1H NMR(CDCl3)δ1.75(s,3H),1.77(s,6H),1.82(s,3H),2.28(s,3H),2.30(s,3H),4.05(t,J=6.0Hz,2H),4.56(d,J=66Hz,2H),5.11(t,J=5.4Hz,1H),5.36(tm,J=6.6Hz,1H),5.54(t,J=6.6Hz,1H),6.97(d,J=9.0Hz,2H),7.08(s,1H),7.15(s,1H),7.27(d,J=9.0Hz,2H),8.34(s,2H)；IR(KBr)3236,1608,1598,1522,1495,1436,1264,1244,1181,998,833,803cm-1.
Ⅰb-392 mp105-106℃；1H NMR(CDCl3)δ1.75(s,3H),1.77(s,6H),1.82(s,3H),2.28(s,3H),2.30(s,3H),4.00-4.09(m,2H),4.63(d,J=6.6Hz,2H),5.14(m,1H),5.37(m,1H),5.55(t,J=6.6Hz,1H),6.98-7.17(m 5H),8.34(s,2H)；IR(KBr)3254,1607,1524,1495,1440,1300,1271,1235,1129,995cm-1.
Ⅰb-393 mp182-184℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),2.29(s,6H),4.05(dd,J=6.6,5.7Hz,2H),5.17(brs,1H),5.37(tm,J=6.6Hz,1H),6.75(d,J=8.7Hz,2H),7.07(s,1H),7.14(s,1H),7.15(d,J=8.7Hz,2H),8.34(s,2H)；IR(KBr)3443,3327,3245,3110,1631,1602,1525,1493,1440,1301,828,802cm-1
Ⅰb-394 mp160-162℃；1H NMR(CDCl3)δ1.74(s,6H),1.77(s,6H),2.29(s,3H),2.30(s,3H),3.74(d,J=6.9Hz,2H),4.05(dd,J=6.6,6.0Hz,2H),5.15(brs,1H),5.37(m,2H),6.67(d,J=8.4Hz,2H),7.07(s,1H),7.16(s,1H),7.18(d,J=8.4Hz,2H),8.34(s,2H)；IR(KBr)3423,3240,3104,1612,1598,1525,1496,1436,1321,1262,1187,1087,824,802cm-1
Ⅰb-395 mp106-108℃；1H NMR(CDCl3)δ1.72(s,6H),1.74(s,9H),1.77(s,3H),2.29(s,3H),2.32(s,3H),3.91(d,J=5.7Hz,4H),4.04(dd,J=6.3,5.7Hz,2H),5.08(m,1H),5.27(m,2H),5.37(m,1H),6.72(brd,J=8.7Hz,2H),7.07(s,1H),7.17(s,1H),7.21(d,J=8.7Hz,2H),8.34(s,2H)；IR(KBr)3433,3254,3110,1599,1523,1494,1434,1378,1232,1196,1092,817,801cm-1
                         表130
Ⅰb-396 mp84-86℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.79(s,3H),2.23(s,3H),2.28(s,3H),3.71(d,J=6.9Hz,2H),4.93(d,J=6.9Hz,2H),5.32-5.61(m,2H),6.36-6.48(m,2H),7.05(t,J=8.4Hz,1H),7.09(s,1H),7.15(s,1H),8.53(s,2H)IR(KBr):3224,3315,2970,2923,1628,1592,1534,1474,1438,1377,1341,1317,1249,1173,1110,993cm-1
Ⅰb-397 mp150-152℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.80(s,3H),1.81(s,3H),1.99(s,6H),2.00(s,6H),3.74(d,J=6.9Hz,2H),4.95(d,J=7.2Hz,2H),5.37-5.42(m,1H),5.58-5.64(m,1H),6.68-6.71(m,2H),6.93-6.97(m,2H),8.36(s,2H)IR(KBr):3360,2973,2928,2857,1610,1587,1519,1436,1406,1379,1310,1245,1181,983cm-1
Ⅰb-398 mp156-158℃；1H NMR(CDCl3)δ1.60(s,3H),1.75(s,3H),1.77(s,3H),1.82(s,3H),1.97(s,6H),2.03(s,6H),4.04-4.08(m,2H),4.64(d,J=6.6Hz,2H),5.05-5.08(m,1H),5.30-5.41(m,1H),5.54-5.60(m,1H),6.81-6.84(m,1H),6.89(dd,J=1.8,12.0Hz,1H),7.05(t,J=8.7Hz,1H),8.15(s,1H),IR(KBr):3320,2971,2931,2850,1627,1604,1525,1483,1395,1373,1338,1309,1288,1263,1240,1175,1115,1038cm-1.
Ⅰb-399 mp161-163℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),1.97(s,6H),2.02(s,6H),4.64(d,J=6.6Hz,2H),5.13(brs,2H),5.54-5.60(m,1H),6.80-6.84(m,1H),6.88(dd,J=1.8,11.7Hz,1H),7.05(t,J=8.7Hz,1H),8.16(s,1H)IR(KBr):3344,3210,2987,2917,2859,1654,1618,1597,1541,1513,1479,1427,1382,1295,1263,1240,1212,1114,993cm-1.
Ⅰb-400 1H NMR(300MHz,CDCl3)δ1.75(s,3H),1.77(s,6H),1.82(s,3H),2.05(s,3H),2.12(s,3H),3.34(s,3H),3.39(s,3H),4.06(t,J=6.0Hz,2H),4.65(d,J=6.9Hz,2H),5.18(t,J=5.3Hz,1H),5.35-5.42(m,1H),5.53-5.60(m,1H),7.08-6.95(m,3H),8.30(s,2H).
Ⅰb-401 油；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.31(s,3H),2.54(s,3H),4.56(d,J=6.6Hz,2H),5.54(t,J=6.6Hz,1H),6.98(d,J=8.4Hz,2H),7.16(s,1H),7,21(t,J=5.1Hz,1H),7.28(d,J=8.4Hz,2H),7.73(s,1H),8.85(d,J=5.1Hz,2H).
Ⅰb-402 mp93-94℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.31(s,3H),2.54(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.98-7.25(m,5H),7.73(s,1H),8.85(s,1H),8.86(s 1H)；IR(KBr)1573,1560,1521,1414,1299,1277,1260,1238,1130,997cm-1.
Ⅰb-403 mp107-108℃；1H NMR(CDCl3)δ1.74(s,3H),1.77(s,3H),1.81(s,3H),1.83(s,3H),2.32(s,3H),2.39(s,3H),3.67(brs,1H),3.74(d,J=6.8Hz,2H),5.10(d,J=7.1Hz,2H),5.37(brt,J=6.8Hz,1H),5.62(brt,J=7.1Hz,1H),6.67(d,J=8.5Hz,2H),7.02(d,J=9.0Hz,1H),7.17(s,1H),7.20(d,J=8.5Hz,2H),7.33(s,1H),7.52(d,J=9.0Hz,1H)
Ⅰb-404 mp149-151℃；1H NMR(CDCl3)δ1.78(s,6H),1.82(s,3H),2.31(s,3H),2.38(s,3H),4.57(d,J=6.6Hz,2H),5.54(t,J=6.6Hz,1H),6.99(d,J=9.0Hz,2H),7.20(s,1H),7.27(d,J=9.0Hz,2H),7.34(s,1H),7.58(d,J=9.0Hz,1H),7.60(d,J=9.0Hz,1H)；IR(KBr)1610,1572,1517,1496,1421,1411,1249,1179,1142,1012,1004,857,841cm-1.
                        表131
Ⅰb-405 mp94-94.5℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.30(s,3H),2.39(s,3H),4.20(s,3H),4.57(d,J=6.6Hz,2H),5.54(tm,J=6.6Hz,1H),6.98(d,J=8.7Hz,2H),7.04(d,J=9.0Hz,1H),7.18(s,1H),7.28(d,J=8.7Hz,2H),7.34(s,1H),7.53(d,J=9.0Hz,1H)；IR(KBr)1610,1592,1518,1464,1415,1295,1235,1175,1107,1016,867,830cm-1.
Ⅰb-406 mp165-167℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.41(s,3H),3.24(s,6H),4.56(d,J=6.6Hz,2H),5.54(tm,J=6.6Hz,1H),6.87(d,J=9.3Hz,1H),6.97(d,J=9.0Hz,2H),7.15(s,1H),7.28(d,J=9.0Hz,2H),7.36(s,1H)7.38(d,J=9.3Hz,1H)；IR(KBr)1606,1593,1493,1427,1387,1237,1178,1003,847,826cm-1.
Ⅰb-407 mp138-140℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.30(s,3H),2.38(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),7.00-7.13(m,3H),7.19(s,1H),7.34(s,1H),7.56(m,1H)7.62(m,1H)；IR(KBr)1518,1496,1414,1385,1299,1266,1233,1127,994,851cm-1.
Ⅰb-408 mp91-92℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.39(s,3H),4.20(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.90-7.14(m,4H),7.16(s,1H),7.34(s,1H),7.53(d,J=9.0Hz,1H)；IR(KBr)1593,1519,1496,1469,1417,1294,1274,1263,1231,1126,1010,995,845cm-1.
Ⅰb-409 mp132-134℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.41(s,3H),3.24(s,6H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.87(d,J=9.6Hz,1H),6.97-7.15(m,4H),7.36(s,1H),7.37(d,J=9.6Hz,1H)；IR(KBr)1597,1547,1519,1495,1422,1404,1297,1272,1233,1197,1133,993,849cm-1.
Ⅰb-410 mp197-200℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.36(s,3H),4.56(d,J=6.9Hz,2H),4.82(s,2H),5.54(tm,J=6.9Hz,1H),6.83(d,J=9.0Hz,1H),6.97(d,J=9.0Hz,2H),7.16(s,1H),7.27(d,J=9.0Hz,2H),7.3l(s,1H),7.39(d,J=9.0Hz,1H)；IR(KBr)3486,3370,3308,3164,1649,1625,1606,1516,1495,146l,1234,1216,1173,1011,999,982,846,835cm-1.
Ⅰb-411 mp183-185℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.28(s,3H),2.36(s,3H),4.64(d,J=6.6Hz,2H),4.89(brs,2H),5.55(tm,J=6.6Hz,1H),6.85(d,J=9.0Hz,1H),6.98-7.12(m,3H),7.14(s,1H),7.32(s,1H),7.38(d,J=9.0Hz,1H)；IR(KBr)3486,3368,3308,3161,1649,1624,1519,1497,1461,1261,1123,982,844cm-1.
Ⅰb-412 mp138-140℃；1H NMR(CDCl3)δ1.76(s,6H),1.77(s,3H),1.82(s,3H),2.29(s,3H),2.39(s,3H),4.03(t,J=6.3Hz,2H),4.56(d,J=6.9Hz,2H),4.77(m,1H),5.38(tm,J=6.9Hz,1H),5.54(tm,J=6.9Hz,1H),6.70(d,J=9.0Hz,1H),6.97(d,J=9.0Hz,2H),7.15(s,1H),7.28(d,J=9.0Hz,2H),7.33(s,1H),7.35(d,J=9.0Hz,1H)；IR(KBr)3213,1605,1530,1492,1234,1180,994,841cm-1.
Ⅰb-413 mp113-115℃；1H NMR(CDCl3)δ1.76(s,3H),1.77(s,3H),1.78(s,3H),1.81(s,3H),2.28(s,3H),2.39(s,3H),3.98-4.15(m,2H),4.64(d,J=6.9Hz,2H),4.76(m,1H),5.38(m,1H),5.55(tm,J=6.9Hz,1H),6.70(d,J=9.3Hz,1H),6.98-7.15(m,4H),7.33(s,1H),7.35(d,J=9.3Hz,1H)；IR(KBr)3424,3214,1601,1534,1492,1416,1296,1261,1232,1126,983,829cm-1.
                        表132
Ⅰb-414 mp159-161℃；1H NMR(CDCl3)δ1.76(s,3H),1.78(s,3H),2.29(s,3H),2.38(s,3H),4.03(dd,J=6.6,5.7Hz,2H),4.91(m,1H),5.38(tm,J=6.6Hz,1H),6.71(d,J=9.0Hz,2H),6.75(d,J=8.7Hz,2H),7.15(s,1H),7.17(d,J=8.7Hz,2H),7.32(s,1H),7.37(d,J=9.0Hz,1H)；IR(KBr)3440,3363,3220,1621,1599,1531,1491,1458,1410,1279,1181,1140,1045,1026,835cm-1
Ⅰb-415 mp131-133℃；1H NMR(CDCl3)δ1.74(s,3H),1.76(s,3H),1.77(s,6H),2.31(s,3H),2.38(s,3H),3.74(d,J=6.9Hz,2H),4.03(dd,J=6.0,6.0Hz,2H),4.87(brs,1H),5.38(m,2H),6.67(d,J=8.4Hz,2H),6.71(d,J=9.3Hz,1H),7.15(s,1H),7.19(d,J=8.4Hz,2H),7.32(s,1H),7.36(d,J=9.3Hz,1H)；IR(KBr)3385,3207,1609,1529,1493,1457,1186,1045,834cm-1
Ⅰb-416 mp174-175℃；1H NMR(CDCl3)δ1.72(s,6H),1.74(s,3H),1.75(s,3H),1.76(s,3H),1.78(s,3H),2.33(s,3),2.38(s,3H),3.91(d,J=6.0Hz,4H),4.03(dd,J=6.0,6.0Hz,2H),4.88(m,1H),5.26(m,2H),5.38(m,1H),6.71(d,J=9.0Hz,1H),6.75(d,J=9.0Hz,2H),7.17(s,1H),7.22(d,J=9.0Hz,2H),7.32(s,1H),7.37(d,J=9.0Hz,1H)；IR(KBr)3432,3252,3133,1615,1578,1524,1473,1449,1350,1316,1305,1234,1195,1162,1057,854,819cm-1.
Ⅰb-417 mp224-227℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.95(s,6H)；1.96(s,6H)；4.64(d,J=6.6Hz,2H)；4.91(br s,2H)；5.57(m,1H)；6.75-7.07(m,4H)；7.20(dd,J=1.8,9.0Hz,1H)；IR(KBr):3341,3163,1637,1513,1460,1297,1263,1243,1114,1001cm-1.
Ⅰb-418 mp215-216℃；1H NMR(CDCl3)δ1.77(s,6H)；1.79(s,3H)；1.82(s,3H)；1.95(s,6H)；1.97(s,6H)；4.02(t,J=6.3Hz,2H)；4.64(d,J=7.2Hz,2H)；4.84(br,1H)；5.39(m,1H)；5.57(m,1H)；6.74(dd,J=1.2,9.0Hz,1H)；6.76-6.93(m,2H)；7.04(t,J=8.4Hz,1H)；7.15(dd,J=1.8,9.0Hz,1H)；IR(KBr):3258,2917,1609,1513,1486,1466,1426,1297,1264,1241,1118cm-1.
Ⅰb-419 mp178-180℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),1.82(s,3H),1.85(s,3H),1.95(s,6H),1.98(s,6H),3.4(brs,1H),3.75(d,J=6.9Hz,2H),5.11(d,J=6.9Hz,2H),5.40(t,J=6.9Hz,1H),5.63(d,J=6.9Hz,1H),6.70-6.74(m,2H),6.92-6.99(m,2H),7.04(d,J=9.2Hz,1H),7.32(d,J=9.2Hz,1H)；IR(KBr):3368,2979,2932,2915,1612,1520,1438,1303,1285,966,821,529cm-1.
Ⅰb-420 1H NMR(300MHz,CDCl3)δ1.77(s,6H),1.79(d,J=1.2Hz,3H),1.82(d,J=0.9Hz,3H),2.04(s,3H),2.12(s,3H),3.35(s,3H),3.42(s,3H),4.02(t,J=6.2Hz,2H),4.65(d,J=6.9Hz,2H),4.81(t,J=5.0Hz,1H),5.35-5.42(m,1H),5.53-5.60(m,1H),6.72(d,J=9.2Hz,1H),6.95-7.08(m,3H),7.29(d,J=9.2Hz,1H).
Ⅰb-421 mp88-89℃；1H NMR(CDCl3)δ1.78(s,3H),1.82(s,3H),2.31(s,3H),2.40(s,3H),4.57(d,J=6.6Hz,2H),5.54(t,J=6.6Hz,1H),6.98(d,J=9.0Hz,2H),7.19(s,1H),7.28(d,J=9.0Hz,2H),7.35(s,1H),8.53(d,J=2.7Hz,1H),8.68(dd,J=2.7,1.2Hz,1H),8.78(d,J=1.2Hz,1H)；IR(KBr)1606,1574,1516,1496,1469,1386,1241,1178,1145,1011,1002,982,840,833cm-1.
Ⅰb-422 mp87-88℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.31(s,3H),2.40(s,3H),4.64(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.99-7.14(m 3H),7.17(s,1H),7.35(s,1H),8.54(m,1H),8.68(m,1H),8.77(m,1H)；IR(KBr)1517,1501,1476,1447,1397,1387,1315,1297,1265,1234,1198,1127,996,849cm-1.
                           表133
Ⅰb-423 mp74-77℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.29(s,3H),2.37(s,3H),4.56(d,J=6.9Hz,2H),4.60(s,2H),5.54(tm,J=6.9Hz,1H),6.97(d,J=8.7Hz,2H),7.14(s,1H),7.27(d,J=8.7Hz,2H),7.29(s,1H),8.10(s,1H),8.18(s 1H)；IR(KBr)3464,3319,3165,1606,1477,1381,1241,1178,1023,1002,839,832cm-1.
Ⅰb-424 mp127-128℃；1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.28(s,3H),2.37(s,3H),4.62(s,2H),4.63(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.98-7.12(m,3H),7.13(s,1H),7.29(s 1H),8.09(d,J=1.5Hz,1H),8.17(d,J=1.5Hz,1H)；IR(KBr)3426,3306,3189,1641,1580,1536,1517,1498,1482,1393,1292,1281,1265,1231,1121,982cm-1.
Ⅰb-425 mp136-138℃；1H NMR(CDCl3)δ1.77(s,3H),1.82(s,3H),2.28(s,3H),2.38(s,3H),3.74(m,1H),4.56(d,J=6.9Hz,2H),5.54(tm,J=6.9Hz,1H),6.97(d,J=8.7Hz,2H),7.13(s,1H),7.27(d,J=8.7Hz,2H),7.29(s,1H),7.96(d,J=1.2Hz,2H),8.16(d,J=1.2Hz,1H)；IR(KBr)3282,1597,1527,1492,1241,1174,1018,885,826cm-1.
Ⅰb-426 mp119-121℃；1H NMR(CDCl3)δ1.77(s,3H),1.81(s,3H),2.28(s,3H),2.38(s,3H),3.74(m,1H),4.57(d,J=8.1Hz,1H),4.63(d,J=6.6Hz,2H),5.55(t,J=6.6Hz,1H),6.98-7.12(m,3H),7.11(s,1H),7.29(s,1H),7.96(d,J=1.5Hz,1H),8.15(d,J=1.5Hz,1H)；IR(KBr)3424,3275,1598,1528,1495,1280,1265,1173,1018,1007cm-1.
Ⅰb-427 mp134-136℃；1H NMR(CDCl3)δ1.77(s,3H),1.78(s,6H),1.82(s,3H),2.29(s,3H),2.38(s,3H),3.98(t,J=5.4Hz,2H),4.56(d,J=6.9Hz,2H),5.36(tm,J=6.9Hz,1H),5.54(tm,J=6.9Hz,1H),6.97(d,J=8.7Hz,2H),7.14(s,1H),7.27(d,J=8.7Hz,2H),7.29(s,1H),7.98(d,J=1.5Hz,1H),8.19(d,J=1.5Hz,1H)；IR(KBr)3215,1608,1578,1561,1492,1380,1362,1243,1179,1166,1017,1003,830cm-1.
Ⅰb-428 mp99-100℃；1H NMR(CDCl3)δ1.76(s,6H),1.78(s,3H),1.81(s,3H),2.28(s,3H),2.38(s,3H),3.98(dd,J=6.6,5.4Hz,2H),4.59(brs,1H),4.63(d,J=6.6Hz,2H),5.36(t,J=6.6Hz,1H),5.55(t,J=6.6Hz,1H),6.98-7.12(m,3H),7.12(s,1H),7.30(s,1H),7.98(d,J=1.5Hz,1H),8.18(d,J=1.5Hz,1H)；IR(KBr)3239,1578,1565,1492,1390,1362,1303,1277,1261,1122,995,873,827cm-1
Ⅰb-429 mp133-134℃；1H NMR(CDCl3)δ1.74(s,3H),1.76(s,3H),1.77(s,3H),1.78(s,3H),2.31(s,3H),2.38(s,3H),3.73(d,J=6.6Hz,2H),3.97(dd,J=6.0,6.0Hz,2H),4.57(m,1H),5.37(m,2H),6.67(d,J=8.4Hz,2H),7.14(s,1H),7.19(d,J=8.4Hz,2H),7.28(s,1H),7.97(d,J=1.5Hz,1H),8.19(d,J=1.5Hz,1H)；1R(KBr)3413,3222,1612,1580,1561,1523,1493,1457,1379,1362,1319,1186,1165,1094,1056,1017,822cm-1
Ⅰb-430 Oil 1H NMR(CDCl3)δ1.72(s,6H),1.74(s,6H),1.76(s,3H),1.78(s,3H),2.33(s,3H),2.37(s,3H),3.90(d,J=6.3Hz,4H),3.97(dd,J=6.0,5.1Hz,2H),4.54(m,1H),5.26(m,2H),5.36(m,1H),6.74(d,J=8.7Hz,2H),7.15(s,1H),7.21(d,J=8.7Hz,2H),7.15(s,1H),7.21(d,J=8.7Hz,2H),7.28(s,1H),7.98(d,J=1.5Hz,1H)8.19(d,J=1.5Hz,1H)
                          表134
Ⅰb-431 mp167-168℃；1H NMR(CDCl3)δ1.75(s,3H),1.78(s,3H),1.81(s,3H),1.84(s,3H),1.95(s,6H),1.98(s,6H),3.63(brs,1H),3.74(d,J=6.6Hz,2H),4.90(d,J=7.1Hz,2H),5.39(t,J=6.6Hz,1H),5.58(d,J=7.1Hz,1H),6.67-6.71(m,2H),6.87-7.00(m,2H),8.07(d,J=1.5Hz,1H),8.35(d,J=1.5Hz,1H)；IR(KBr):3355,2964,2926,2874,1614,1521,1458,1345,1312,1270,1029,977,820cm-1.
Ⅰb-432 mp161-162℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.94(s,6H)；1.97(s,6H)；4.64(d,J=6.3Hz,2H)；4.64(brs,2H)；5.57(m,1H)；6.74-7.07(m,3H)；7.98(s,1H)；8.15(s,1H)；IR(KBr):3450,3340,2921,1624,1527,1514,1461,1374,1295,1261,1245,1192,1116cm-1.
Ⅰb-433 mp130-132℃；1H NMR(CDCl3)δ1.77(s,6H)；1.80(s,3H)；1.82(s,3H)；1.94(s,6H)；1.98(s,6H)；3.98(brt,J=5.4Hz,2H)；4.56(br,1H)；4.64(d,J=6.6Hz,2H)；5.39(m,1H)；5.57(m,1H)；6.74-7.08(m,3H)；7.99(s,1H)；8.02(s,1H)；IR(KBr):3244,2918,1584,1560,1514,1468,1380,1295,1264,1241,1114cm-1.
Ⅰb-434 无定形；1H NMR(CDCl3)δ1.77(s,3H),1.80(s,3H),1.96(s,6H),1.98(s,6H),3.5(brs,2H),3.98(m,2H),4.64(m,1H),5.39(m,1H),6.74-6.79(m,2H),6.84-6.99(m,2H),7.99(d,J=1.4Hz,1H),8.04(d,J=1.4Hz,1H)；IR(KBr):3334,1620,1588,1519,1462,1276,1161,1024,824,525cm-1
Ⅰb-435 mp180-182℃；1H NMR(CDCl3)δ1.74(s,3H),1.74(s,3H),1.78(s,3H),1.79(s,3H),1.97(s,6H),1.98(s,6H),3.4(brs,1H),3.74(d,J=6.9Hz,2H),3.98(t,J=6.0Hz,2H),4.50(t,J=5.1Hz,1H),5.36-5.41(m,2H),6.66-6.72(m,2H),6.86-7.02(m,2H),8.00(d,J=1.4Hz,1H),8.02(d,J=1.4Hz,1H)；IR(CHCl3):3439,1613,1585,1519,1468cm-1
Ⅰb-436 1H NMR(300MHz,CDCl3)δ1.77(s,6H),1.79(d,J=0.9Hz,3H),1.81(s,3H),2.04(s,3H),2.08(s,3H),3.34(s,3H),3.41(s,3H),3.99(t,J=5.3Hz,2H),4.64(d,J=6.9Hz,2H),4.58-4.67(m,1H),5.34-5.42(m,1H),5.53-5.60(m,1H),6.93-7.07(m,3H),8.02(d,J=1.5Hz,1H),8.11(d,J=1.5Hz,1H).
Ⅰb-437 泡沫；1H NMR(CDCl3)δ2.21(s,3H),2.28(s,3H),6.34-6.49(m,2H),6.80(d,J=2.1Hz,1H),7.03-7.12(m,3H),7.40(d,J=2.4Hz,1H),7.61(m,1H)IR(KBr):3414,2862,2589,1652,1601,1541,1492,1430,1330,1186,1222,1186,1147,1123,1040,998cm-1
Ⅰb-438 泡沫；1H NMR(CDCl3)δ2.12(s,3H),2.78(s,3H),6.61-6.81(m,3H),6.99-7.06(m,3H),7.41(d,J=2.1Hz,1H),7.58(dd,J=2.4,8.7Hz,1H)IR(KBR):3423,2857,2604,1654,1602,1539,1447,1413,1215,1133,1074cm-1
Ⅰb-439 泡沫；1H NMR(CDCl3)δ1.73(s,3H),1.79(s,3H),2.14(s,3H),2.28(s,3H),3.71(d,J=6.6Hz,2H),5.33-5.39(m,1H),6.65-6.83(m,3H),6.99-7.09(m,3H),7.36(d,J=2.7Hz,1H),7.55-7.60(m,1H)IR(KBr):3431,2923,2550,1654,1604,1480,1455,1376,1357,1284,971cm-1
Ⅰb-440 mp193-195℃；1H NMR(CDCl3)δ1.74(s,3H),1.78(s,3H),2.21(s,3H),2.28(s,3H),3.72(d,J=6.9Hz,2H),5.35(t,J=6.9Hz,1H),6.40(dd,J=12.3,2.1Hz,1H),6.46(dd,J=8.4,2.4Hz,1H),6.67(dd,J=9.3,0.6Hz,1H),7.04(t,J=8.4Hz,1H),7.07(s,1H),7.11(s,1H),7.39(dd,J=2.4,0.6Hz,1H),7.56(dd,J=9.3,2.4Hz,1H)；IR(KBr):3413,3302,1660,1620,1497,1466,1421,1337,1232,1174,835cm-1
                          表135
Ⅰb-441 mp247-249℃；1H NMR(CDCl3)δ1.78(s,3H)；1.82(s,3H)；1.96(s,6H)；2.04(s,6H)；4.64(d,J=6.9(d,2H)；5.58(m,1H)；6.72(d,J=9.3Hz,1H)；6.80-6.92(m,2H)；7.05(dt,J=1.2,8.4Hz,1H)；7.22(d,J=1.8Hz,1H)；7.35(ddd,J=1.8,2.4,9.3Hz,1H)；IR(KBr):3444,2917,1661,1619,1512,1294,1262cm-1.
Ⅰb-442 mp172-176℃；1H NMR(CDCl3)δ1.78(s,3H)；1.82(s,3H)；1.95(s,6H)；2.05(s,6H)；4.64(d,J=6.9Hz,2H)；5.57(m,1H)；6.75-7.25(m,5H)；10.81(brs,1H)；IR(KBr):2925,1689,1677,1592,1514,1295,1264,1243,1113,1008cm-1.
Ⅰb-443 mp240-242℃；1H NMR(CDCl3)δ1.77(s,3H)；1.82(s,3H)；1.96(s,6H)；2.06(s,6H)；4.64(d,J=6.3Hz,2H)；5.57(m,1H)；6.74-7.09(m,3H)；7.22(d,J=1.2Hz,1H)；8.42(d,J=1.2Hz,1H)；IR(KBr):2916,1655,1616,1512,1261cm-1.
 Ⅰb-539 1HMR(CDCl3):δ1.59(3H,s),1.74(3H,s),1.79(3H,s),1.83(3H,s),2.20(3H,s),2.28(3H,s),4.32(2H,d,J 7.2Hz),4.89(2H,d,J 6.9Hz),5.32(1H,bt,J7.2Hz),5.58(2H,bt,J 6.9Hz),5.81(2H,bs),6.83(1H,d,J 8.4Hz),7.14(2H,bs),7.03-7.30(3H),7.60(1H,dd,J 8.4Hz,2.4Hz),8.18(1H,d,J 2.4Hz).
 Ⅰb-540 1HNMR(CDCl3):δ1.58(3H,s),1.73(3H,s),1.80(3H,s),1.82(3H,s),2.20(3H,s),2.28(3H,s),2.33(1H,bs),4.25(2H,bs),4.30(2H,d,J 6.9Hz),4.88(2H,d,J 6.9Hz),5.30(1H,bt,J 6.9Hz),5.58(2H,bt,J 6.9Hz),5.90(2H,bs),6.83(1H,d,J 8.4Hz),6.95-7.30(3H),7.13(2H,bs),7.60(1H,dd,J 8.4Hz,2.4Hz),8.18(1H,d,J 2.4Hz).
 Ⅰb-541 1HMR(CDCl3):δH 1.58(3H,s),1.73(3H,s),1.79(3H,s),1.82(3H,s),2.20(3H,s),2.28(3H,s),2.71(4H,s),4.29(2H,d,J 7.2Hz),4.88(2H,d,J6.9Hz),5.30(1H,bt,J 6.9Hz),5.57(2H,bt,J 7.2Hz),5.80(2H,bs,),6.82(1H,d,J 8.1Hz),6.97-7.27(3H),7.13(1H,d,J 2.4Hz),7.60(1H,dd,J 8.1Hz,2.4Hz),8.18(1H,bs).
 Ⅰc-1 119-120℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.17(3H,s),2.24(3H,s),4.61(2H,d,J=6.8),4.63(1H,s),5.52(1H,brt,J=6.8),5.71(1H,s),6.66(1H,s),6.76(1H,dd,J=2.2,8.3),6.80(2H,d,J=8.3),6.86-6.91(4H,m),7.071H,s)
 Ⅰc-2 oil,1H-NMR(CDCl3)δ1.75(3H,s),1.78(3H,s),2.17(3H,s),2.25(3H,s),3.87(3H,s),4.62(2H,d,J=6.6),4.67(1H,s),5.56(1H,brt,J=6.6),6.68(1H,s),3.79-6.93(7H,m),7.09(1H,s)
 Ⅰc-3 oil,1H-NMR(CDCl3)δ2.18(3H,s),2.22(3H,s),3.14(3H,s),5.16(2H,s),5.71(1H,s),6.77(1H,dd,J=2.0,8.3),6.81(1H,s),6,93-6.99(4H,m),7.10(1H,s),7.22(2H,d,J=9.0),7.39-7.47(5H,m)
 Ⅰc-4 oil,1H-NMR(CDCl3)δ2.19(3H,s),2.21(3H,s),3.11(3H,s),3.15(3H,s),5.15(2H,s),6.82(1H,s),6.95(2H,d,J=9.3),7.10(1H,s),7.11(1H,d,J=8.3),7.21(1H,dd,J=2.2,8.3),7.23(2H,d,J=9.3),7.31(1H,d,J=2.2),7.37-7.49(5H,m)
  Ⅰc-5 oil,1H-NMR(CDCl3)δ2.19(3H,s),2.20(3H,s),3.14(3H,s),3.91(3H,s),5.20(2H,s),6.79(1H,dd,J=2.0,8.1),6.81(1H,s),6.86(1H,d,J=2.0),6.93(1H,d,J=8.1),6.95(2H,d,J=9.0),7.11(1H,s),7.22(2H,d,J=9.0),7.32-7.49(5H,m)
  Ⅰc-6 oil,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.19(3H,s),2.21(3H,s),3.14(3H,s),3.22(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),6.82(1H,s),6.95(2H,d,J=9.0),7.04(1H,d,J=8.3),7.11(1H,s),7.21(1H,dd,J=2.2,8.3).7.23(2H.d.J=9.0),7.29(1H,d,J=2.2)
                       表136
  Ⅰc-7 油，1H-NMR(CDCl3)δ1.76(3H,s),1.80(3H,s),2.20(3H,s),2.22(3H,s),3.15(3H,s),3.89(3H,s),4.63(2H,d,J=6.8),5.57(1H,brt,J=6.8),6.81-6.85(3H,m),6.93(1H,d,J=8.8),6.96(2H,d,J=8.8),7.13(1H,s),7.22(2H,d,J=8.8)
  Ⅰc-8 162-163℃,1H-NMR(CDCl3)δ2.14(3H,s),2.26(3H,s),3.55(2H,brs),3.89(3H,s),5.19(2H,s),6.64(1H,s),6.68(2H,d,J=8.8),6.77(1H,dd,J=2.0,8.7),6.84(2H,d,J=8.8),6.85(1H,d,J=2.0),6.91(1H,d,J=8.7),7.06(1H,s),7.31-7.49(5H,m)
  Ⅰc-9 111-112℃,1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.16(3H,s),2.27(3H,s),3.56(2H,brs),3.87(3H,s),4.62(2H,d,J=6.8),5.56(1H,brt,J=6.8),6.65(1H,s),6.68(2H,d,J=9.0),6.79-6.92(5H,m),7.08(1H,s)
  Ⅰc-12 油，1H-NMR(CDCl3)δ2.14(3H,s),2.28(3H,s),2.93(6H,s),3.89(3H,s),5.19(2H,s),6.64(1H,s),6.74(2H,d,J=9.0),6.78(1H,dd,J=2.0,8.3),6.85(1H,d,J=2.0),6.91(1H,d,J=8.3),6.93(2H,d,J=9.0).7.31-7.49(5H,m)
  Ⅰc-14 油，1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.16(3H,s),2.28(3H,s),2.93(6H,s),3.87(3H,s),4.62(2H,d,J=6.8),5.56(1H,brt,J=6.8),6.65(1H,s),6.75(2H,d,J=9.0),6.80-6.83(2H,m),6.90(1H,d,J=8.6),6.93(2H,d,J=9.0),7.08(1H,s)
  Ⅰc-16 119-120℃,1H-NMR(CDCl3)δ2.13(3H,s),2.27(3H,s),3.01(6H,s),6.78(1H,d,J=9.3).6.80(2H,d,J=8.8),6.89(1H,s),7.16(1H,s),7.22(2H,d,J=8.8),8.04(1H,dd,J=2.7,9.3),8.39(1H,d,J=2.7)
  Ⅰc-17 80-82℃,1H-NMR(CDCl3)δ2.17(3H,s),2.30(3H,s),2.98(6H,s),3.61(2H,brs),6.50(1H,s),6.55(1H,dd,J=2.7,8.6),6.77(2H,d,J=9.0),6.81(1H,d,J=2.7),6.82(1H,d,J=8.6),7.07(1H,s),7.20(2H,d,J=9.0),
  Ⅰc-18 141-142℃,1H-NMR(CDCl3)δ2.21(3H,s),2.22(3H,s),3.00(6H,s),3.03(3H,s),6.41(1H,brs),6.71(1H,s),6.78(2H,d,J=8.8),6.82(1H,d,J=8.8),7.06(1H,dd,J=2.7,8.8),7.11(1H,s),7.21(2H,d,J=8.8),7.39(1H,d,J=2.7)
  Ⅰc-19 138-139℃,1H-NMR(CDCl3)δ2.20(3H,s),2.22(3H,s),3.00(6H,s),6.72(1H,s),6.78(2H,d,J=8.8),6.85(1H,d,J=8.8),7.12(1H,s),7.21(2H,d,J=8.8),7.35(1H,dd,J=2.7,8.8),7.77(1H,d,J=2.7),7.82(1H,brs),
  Ⅰc-20 油，1H-NMR(CDCl3)δ1.73(3H,s),1.77(3H,s),2.16(3H,s),2.31(3H,s),2.98(6H,s),3.67(2H,d,J=6.6),5 33(1H,brt,J=6.6),6.48(1H,dd,J=2.7,8.8),6.49(1H,s),6.71(1H,d,J=2.7),6.77(2H,d,J=8.8),6.85(1H,d,J=8.8),7.07(1H,s),7.20(2H,d,J=8.8)
  Ⅰc-23 126-128℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.26(3H,s),2.353H,s),4.58(1H,brs),4.61(2H,d,J=6.8),4.96(2H,s),5.52(1H,brt,J=6.8),5.72(1H,s),6.75-6.81(3H,m),6.89-6.92(4H,m),7.08(1H,s),7.27(1H,s)
  Ⅰc-24 油，1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.26(3H,s),2.35(3H,s),3.21(3H,s),4.53(1H,s),4.62(2H,d,J=6.8),4.96(2H,s)5.50(1H,brt,J=6.8),6.78(2H,d,J=9.0),6.90(2H,d,J=9.0),7.03(1H,d,J=8.5),7.071H,s),7.20(1H,dd,J=2.2,8.5),7.28(1H,s),7.29(1H,d,J=2.2)
  Ⅰc-25 146-147℃,1H-NMR(CDC13)δ1.75(3H,s),1.79(3H,s),2.25(3H,s),2.26(3H,s),3.86(3H,s),4.62(2H,d,J=6.8),4.78(1H,s),5.02(2H,s),5.56(1H,brt,J=6.8),6.79-6.82(3H,m),6.86(2H,d,J=8.5),6.90(1H,d,J=8.8),7.04(1H,s),7.35(2H,d,J=8.5)
  Ⅰc-32 123-124℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.26(6H,s9,3.17(3H,s),3.21(3H,s),4.61(2H,d,J=6.8),5.10(2H,s),5.50(1H,brt,J=6.8),6.76(1H,s),7.02(1H,d,J=8.3),7.04(1H,s),7.18(1H,dd,J=2.2,8.3),7.27(1h,d,J=2.2),7.33(2H,d,J=8.8),7.53(2H,d,J=8.8)
                       表137
  Ⅰc-33 125-127℃,1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.24(3H,s),2.35(3H,s),3.87(3H,s),4.21(2H,s9,4.61(2H,d,J=6.6),5.56(1H,brt,J=6.6),6.59(2H,d,J=8.8),6.73(2H,d,J=8.8),6.81-6.85(2H,m),6.92(1H,d,J=8.8),7.08(1H,s),7.23(1H,s)
  Ⅰc-35 141-142℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.30(3H,s),2.40(3H,s),4.61(2H,d,J=6.8),4.79(1H,s),5.53(1H,brt,J=6.8),5.70(1H,s),6.79(1H,dd,J=2.2,8.3),6.84(2H,d,J=8.8),6.91(1H,d,J=8.3),6.93(1H,d,J=2.2),6.97(1H,d,J=16.1)7.04(1H,s),7.18(1H,d,J=16.1),7.43(2H,d,J=8.8),7.46(1H,s),
  Ⅰc-38 140-142℃,1H-NMR(CDCl3)δ1.77(3H,s),1.82(3H,s),2.30(3H,s),2.41(3H,s),3.16(3H,s),3.22(3H,s),4.63(2H,d,J=6.8),5.51(1H,brt,J=6.8),7.02(1H,d,J=15.4),7.04(1H,d,J=8.3),7.05(1H,s),7.22(1H,dd,J=2.2,8.3),7.29(2H,d,J=8.8),7.30(1H,d,J=2.2),7.31(1H,d,J=15.4),7.48(1H,s),7.57(2H,d,J=8.8)
  Ⅰc-43 146-147℃,1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.25(3H,s),2.48(3H,s),3.88(3H,s),4.62(2H,d,J=6.8),5.04(1H,s),5.56(1H,brt,J=6.8),6.81-6.85(4H,m),6.92(1H,d,J=8.8),7.10(1H,s),7.38(1H,s),7.44(2H,d,J=8.6)
  Ⅰc-44 121-122℃,1H-NMR(CDCl3)δ1.76(3H,s),1.79(3H,s),2.26(3H,s),2.49(3H,s),3.17(3H,s),3.88(3H,s),4.63(2H,d,J=6.8),5.56(1H,brt,J=6.8),6 81-6.85(2H,m),6.93(1H,d,J=8.8),7.12(1H,s),7.29(2H,d,J=8.8),7.40(1H,s),7.59(2H,d,J=8.8)
  Ⅰc-47 油，1H-NMR(CDCl3)δ1.76(3H,s),1.79(3H,s9,2.26(3H,s),2.29(3H,s),3.89(3H,s),4.64(2H,d,J=6.6),5.57(1H,brt,J=6.6),5.82(1H,s),6.85-6.88(2H,m),6.90(2H,d,J=8.8),6.95(1H,d,J=8.5),7.14(1H,s),7.18(1H,s),7.81(2H,d,J=8.8)
  Ⅰc-49 油，1H-NMR(CDCl3)δ1.75(3H,s),1.79(3H,s),2.07(1H,d,3.7),2.21(3H,s),2.28(3H,s),3.87(3H,s),4.62(2H,d,J=6.8),4.81(1H,s),5.56(1H,brt,J=6.8),5.96(1H,d,J=3.7),6.81(2H,d,J=8.8)6.82-6.85(2H,m),6.92(1H,d,J=8.8),7.02(1H,s),7.25(2H,d,J=8.8),7.42(1H,s)
  Ⅰe-4 170-170.5℃,1H-NMR(CDCl3)δ5.15(2H,s),5.75(1H,s),6.94(1H,dd,J=0.7,8.5),6.98(2H,m),7.06-7.16(5H,m),7.37-7.44(5H,m),7.83(1H,dd,J=2.4,8.5),8.34(1H,dd,J=0.7,2.4)
  Ⅰe-5 122-122.5℃
  Ⅰe-6 175-176℃,1H-NMR(CDCl3)δ2.38(3H,s),5.11(2H,s),5.75(1H,s),6.94(1H,d,J=8.3),6.98(2H,m),7.05-7.17(5H,m),7 22(2H,d,J=8.1),7.32(2H,d,J=8.1),7.83(1H,dd,J=2.4,8.6),8.34(1H,d,J=2.4)
  Ⅰe-7 144.5-145.5℃,1H-NMR(CDCl3)δ2.37(3H,s),3.11(3H,s),5.12(2H,s),6.961H,d,J=8.6),7.10-7.15(5H,m),7.21(2H,d,J=8.1),7.33(2H,d,J=8.1),7.39(1H,dd,J=2.2,8.6),7.47(1H,d,J=2.2),7.83(1H,dd,J=2.7,8.6),8.331H,d,J=2.7)
  Ⅰe-8 125-127℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),4.61(2H,d,J=6.8),5.51(1H,brt,J=6.8),5.76(1H,s),6.91-7.01(3H,m),7.06-7.16(5H,m),7.83(1H.dd,J=2.4,8.6),8.34(1H,dd,J=0.7,2.4)
  Ⅰe-9 127-128℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),3.22(3H,s),4.62(2H,d,J=6.8),5.48(1H,brt,J=6.8),6.96(1H,dd,J=0.7,8.6),7.06-7.15(5H,m),7.40(1H,dd,J=2.2,8.6),7.46(1H,d,J=2.2),7.83(1H,dd,J=2.4,8.6),8.33(1H,dd,J=0.7,2.4)
  Ⅰe-13 153-154℃,1H-NMR(CDCl3)δ2.25(3H,s),3.10(3H,s),3.78(3H,s).5.16(2H,s),7.13(2H,s),7.19-7.25(4H,m),7.36-7.48(7H,m)
                              表138
 Ⅰe-14 油，1H-NMR(CDCl3)δ2.23(3H,s),2.39(3H,s),3.77(3H,s),5.09(2H,s),5.74(1H,s),6.69(1H,dd,J=1.8,8.5),6.82(1H,d,J=1.8),6.98(1H,d,J=8.5),7.18-7.43(9H,m)
 Ⅰe-15 166-167℃,1H-NMR(CDCl3)δ2.25(3H,s),2.38(3H,s),3.09(3H,s),3.78(3H,s),5.11(2H,s),7.12(2H,s),7.15-7.44(10H,m)
 Ⅰe-17 132-133℃,1H-NMR(CDCl3)δ2.25(3H,s),3.10(3H,s),3.79(3H,s),3.83(3H,s),5.16(2H,s),6.91(2H,d,J=9.1),6.94-7.23(5H,m),7.36-7.48(5H,m)
 Ⅰe-18 油，1H-NMR(CDCl3)δ2.24(3H,s),2.39(3H,s),3.78(3H,s),3.83(3H,s),5.09(2H,s),5.71(1H,d,J=1.8),6.68(1H,dd,J=1.8,7.9),6.82(1H,d,J=1.8),6.90(2H,d,J=1.8),6.98(1H,d,J=7.9),7.16(2H,d,J=1.8),7.23(2H,d,J=7.9),7.33(2H,d,J=7.9)
 Ⅰe-19 113-114℃,1H-NMR(CDCl3)δ2.24(3H,s),2.38(3H,s),3.09(3H,s),3.78(3H,s),3.83(3H,s),5.11(2H,s),6.91(2H,d,J=8.5),7.34(2H,d,J=8.5)
 Ⅰe-23 157-158℃
 Ⅰe-24 114-116℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.23(3H,s),3.78(3H,s),4.60(2H,d,J=6.8),5.52(1H,brt,J=6.8),5.74(1H,s),6.67(1H,dd,J=2.0,8.3),6.79(1H,d,J=2.0),6.91(1H,d,J=8.3),7.07(1H,dd,J=8.3,9.3),7.21(1H,dd,J=4.6,8.3)
 Ⅰe-25 107-108℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.25(3H,s),3.21(3H,s),3.79(3H,s),4.62(2H,d,J=6.6),5.50(1H,brt,J=6.6),7.03-7.23(7H,m)
 Ⅰe-27 177-178℃,1H-NMR(CDCl3)δ2.24(3H,s),3.10(3H,s),3.92(3H,s),5.16(2H,s),6.99-7.49(11H,m),7.66(2H,d,J=7.9)
 Ⅰe-28 170-172℃,1H-NMR(CDCl3)δ2.22(3H,s),2.39(3H,s),3.92(3H,s),5.09(2H,s),5.71(1H,s),6.71(1H,dd,J=1.8,7.9),6.84(1H,d,J=1.8),6.98(1H,d,J=7.9),7.03(2H,d,J=7.3),7.23(2H,d,J=7.9),7.29-7.36(3H,m),7.67(2H,dd,J=1.2,8.5)
 Ⅰe-29 169-170℃,1H-NMR(CDCl3)δ2.24(3H,s),2.38(3H,s),3.10(3H,s),3.92(3H,s),5.11(2H,s),6.99-7.37(10H,m),7.66(2H,d,J=7.9)
 Ⅰe-31 150-151℃,1H-NMR(CDCl3)δ2.22(3H,s),3.10(3H,s),3.81(3H,s),3.88(3H,s),5.15(2H,s),6.87(1H,s),6.89(2H,dJ=9.1),7.09(1H,d,J=8.5),7.14(1H,dd,J=1.8,8.5),7.24(1H,d,J=1.8),7.36-7.53(5H,m),7.55(2H,d,J=9.1)
 Ⅰe-32 175-176℃,1H-NMR(CDCl5)δ2.20(3H,s),2.39(3H,s),3.81(3H,s),3.88(3H,s),5.09(2H,s),5.68(1H,s),6.70(1H,dd,J=1.8,7.9),6.83(1H,d,J=1.8),6.85(1H,brs),6.88(2H,d,J=9.2),6.97(1H,d,J=7.9),7.23(2H,d,J=7.9),7.34(2H,d,J=7.9),7.55(2H,d,J=9.2)
 Ⅰe-33 176-177℃,1H-NMR(CDCl3)δ2.22(3H,s),2.37(3H,s),3.09(3H,s),3.81(3H,s),3.88(3H,s),5.10(2H,s),6.87(1H,s),6.89(2H,d,J=8.5),7.09(1H,d,J=8.5),7.14(1H,dd,J=1.8,8.5),7.22(2H,dJ=8.5),7.23(1H,s),7.34(2H,d,J=8.5),7.55(2H,d,J=8.5)
 Ⅰe-38 188-189℃,1H-NMR(CDCl3)δ2.21(3H,s),2.39(3H,s),3.89(3H,s),5.092H,s),5.68(1H,s),6.70(1H,dd,J=1.8,7.9),6.83(1H,d,J=1.8),6.91-7.064H,m),7.23(2H,d,J=8.5),7.34(2H,d,J=8.5),7.56-7.65(2H,m)
 Ⅰe-39 194-195℃,1H-NMR(CDCl3)δ2.23(3H,s),2.38(3H,s),3.09(3H,s),3.89(3H,s),5.11(2H,s),6.94-7.21(5H,m),7.22(2H,d,J=1.8),7.23(1H,s),7.35(2H,d,J=7.9),7.57-7.63(2H,m)
 Ⅰe-40 159-160℃,1H-NMR(CDCl3)δ1.76(3H,s),1.82(3H,s),2.21(3H,s),3,89(3H,s),4.60(2H,d,J=6.7),5.52(1H,t,J=6.7),5.71(1H,s),6.68(1H,dd,J=1.8,8.5),6.81(1H,d,J=1.8),6.90(1H,d,J=8.5),7.02(2H,t,J=8.5),7.57-7.65(2H,m)
                                       表139
 Ⅰe-41 142-143℃,1H-NMR(CDCl3)δ1.76(3H,s),1.81(3H,s),2.24(3H,s),3.21(3H.s).3.89(3H.s).4.62(2H.d,J=7.3).5.50(1H.t.J=7.3).6.94(1H,s),6.99-7.08(3H,m),7.13(1H,dd,J=2.4,8.5),7.22(1H,d,J=2.4),7.56-7.65(2H,m)
 Ⅰf-10 151-152℃,1H-NMR(CDCl3)δ2.18(3H,s).3.09(3H.s).3.75-3.81(8H.m),3.83(3H,s),5.14(2H,s),7.08(1H,d,J=8.5),7.11(1H,dd,J=1.7,8.5),7.21(1H,d,J=1.7),7.35-7.47(5H,m)
 Ⅰf-14 140-141℃,1H-NMR(CDCl3)δ2.18(3H,s),2.36(3H,s),2.48(4H,t,J=5.5),3.09(3H,s),3.83(3H,s),3.87(4H,t,J=5.5),5.14(2H,s),7.07(1H,d,J=8.5),7.11(1H,dd,J=1.8,8.5),7.21(1H,d,J=1.8),7.33-7.49(5H,m)
 Ⅰf-18 152-153℃,1H-NMR(CDCl3)δ2.20(3H,s),3.09(3H,s),3 26(4H,t,J=5.5),3.86(3H,s),4.01(4H,t,J=5.5),5.14(2H,s),6.90(1H,d,J=7.3),7.00(2H,d,J=7.3),7.08(1H,d,J=8.5),7.12(1H,dd,J=1.8,8.5),7.21-7.49(8H,m)
 Ⅰf-26 195-197℃,1H-NMR(CDCl3)δ2.44(3H,s),3.12(3H,s),4.05(3H,s),5.18(2H,s),7.14-7.21(2H,m),7.28(1H,m),7.38-7.48(5H,m),8.17(1H,s),9.22(1H,s)
Ⅰf-29 mp122.5-123.5℃,1H NMR(CDCl3)δ1.74(s,3H),1.78(s,6H),1.81(s,3H),2.36(s,3H),2.57(brs,3H),3.74(d,J=6.9Hz,2H),4.88(d,J=6.9Hz,2H),5.37(brt,J=6.9Hz,1H),5.55(brt,J=6.9Hz,1H),5.68(d,J=8.7Hz,2H),6.84(dd,J=0.6,8.7,1H),7.19(d,J=8.7Hz,2H),7.43(brs,1H),7.83(dd,J=2.4,8.7Hz,1H),8.38(dd,J=0.6,2.4Hz,1H)
Ⅰf-30 mp122.5-123.5℃,1H NMR(CDCl3)δ1.78(s,3H),1.81(s,3H),2.37(s,3H),2.58(brs,3H),4.88(d,J=7.2Hz,2H),5.56(brt,J=7.2Hz,1H),6.77(d,J=8.4Hz,2H),6.85(dd,J=0.6.8.4.1H),7.16(d,J=8.4Hz,2H),7.45(brs,1H),7.84(dd,J=2.4,8.4Hz,1H),8.38(dd,J=0.6,2.4Hz,1H)
Ⅰg-1 mp176-177℃；1H NMR(CDCl3)δ1.80(s,3H)；1.83(s,3H)；1.98(s,6H)；2.00(s,6H)；4.51(brs,2H)；4.88(d,J=6.9Hz,2H)；5.90(m,1H)；6.63(m,1H)；6.85(ddd,J=0.9,1.5,8.4Hz,1H)；7.29(ddd,J=2.1,4.2,8.4Hz,1H)；7.39(ddd,J=1,2,2.4,8.4Hz,1H)；7.90(m,1H)；7.97(m,1H)；IR(KBr):3464,3302,3164,2916,1638,1603,1512,149l,1459,1385,1360,1300,1279,1242cm-1.
Ⅰg-2 mp162-164℃；1HNMR(CDCl3)δ1.75(s,3H)；1.78(s,3H)；1.80(s,3H)；1.83(s,3H)；1.98(s,6H)；2.02(s,6H)；3.91(t,J=5.7Hz,2H)；4.51(brt,1H)；4.88(d,J=7.2Hz,2H)；5.38(m,1H)；5.59(m,1H)；6.50(m,1H)；6.85(ddd,J=0.9,1.5,8.7Hz,1H)；7.27(ddd,J=2.1,4.2,8.7Hz,1H)；7.40(ddd,J=2.4,3.3,8.4Hz,1H)；7.92(m,1H)；7.98(dt,J=0.9,2.4Hz,1H)；IR(KBr):3420,3242,2913,1605,1503,1462,1378,1350,1277,1240cm-1.
Ⅰg-3 1H NMR(300MHz,CDCl3)δ1.80(s,8H),1.83(s,3H),2.07(s,3H),2.09(s,3H),3.34(s,3H),3.36(s,3H),4.59(brs,2H),4.89(d,J=7.2Hz,2H),5.54-5.62(m,1H),6.62(d,J=8.4Hz,1H),6.84(dd,J=8.4,0.7Hz,1H),7.45(dd,J=8.4,2.2Hz,1H),7.54(dd,J=8.4Hz,1H),8.04(d,J=2.2Hz,1H),8.10(dd,J=2.5,0.7Hz,1H)
Ⅰg-4 1H NMR(300MHz,CDCl3)δ1.76(s,3H),1.78(d,J=0.9Hz,3H),1.80(d,J=0.9Hz,3H),1.83(d,J=0.9Hz,3H),2.07(s,3H),2.10(s,3H),3.34(s,3H),3.36(s,3H),3.91(t,J=6.0Hz,2H),4.58(brs,1H),4.88(d,J=6.9Hz,2H),5.34-5.41(m,1H),5.55-5.62(m,1H),6.49(dd,J=8.6,0.7Hz,1H),6.84(dd,J=8.3,0.8Hz,1H),7.43(dd,J=8.6,2.3Hz,1H),7.55(dd,J=8.3,2.3Hz,1H),8.05(dd,J=2.3,0.7Hz,1H),8.11(dd,J=2.3,0.8Hz,1H)
                              表140
Ⅰg-5 mp126-128℃；1H NMR(CDCl3)δ1.75(s,6H),1.78(s,6H),2.07(s,6H),2.55(s,6H),3.90(t,J=6.0Hz,4H),4.53(m,2H),5.37(t,J=6.6Hz,2H),6.47(dd,J=8.4,0.9Hz,2H),7.17(dd,J=8.4,2.4Hz,2H),7.82(dd,J=2.4,0.9Hz,2H)；IR(KBr):3222,1607,1532,1389,1313,981,811cm-1
Ⅰg-6 1H NMR(300MHz,CDCl3)δ1.75(s,6H),1.78(d,J=0.9Hz,6H),2.10(s,6H),3.36(s,6H),3.91(t,J=0.9Hz,4H),4.53(t,J=5.0Hz,2H),5.34-5.42(m,2H),6.48(d,J=8.5Hz,2H),7.42(dd,J=8.5,2.3Hz,2H),8.05(dd,J=2.3,0.8Hz,2H)
Ⅰg-7 1H NMR(300MHz,CDCl3)δ1.80(s,3H),1.83(s,3H),2.08(s,3H),2.12(s,3H),3.34(s,3H),3.39(s,3H),4.89(d,J=6.9Hz,2H),5.17(brs,2H),5.54-5.62(m,1H),684(dd,J=8.6,0.8Hz,1H),7.53(dd,J=8.6,2.3Hz,1H),8.09(dd,J=2.3,0.8Hz,1H),8.32(s,2H)
Ⅰg-8 1H NMR(300MHz,CDCl3)δ1.76(s,3H),1.78(s,3H),1.80(s,3H),1.83(s,3H),2.08(s,3H),2.13(s,3H),3.34(s,3H),3.40(s,3H),4.05(s,J=6.2Hz,2H),4.88(d,J=6.9Hz,2H),5.14-5.18(m,1H),5.35-5.42(m,1H),5.55-5.61(m,1H),6.85(dd,J=8.5,0.7Hz,1H),7.54(dd,J=8.5,2.7Hz,1H),8.10(dd,J=2.7,0.7Hz,1H),8.30(s,2H)
Ⅰg-9 1H NMR(300MHz,CDCl3)δ1.79(s,3H),1.83(d,J=0.9Hz,3H),2.07(s,3H),2.08(s,3H),3.34(s,3H),3.40(s,3H),4.67(brs,2H),4.89(d,J=7.2Hz,2H),5.54-5.62(m,1H),6.84(dd,J=8.6,0.7Hz,1H),7.53(dd,J=8.6,2.5Hz,1H),8.09(dd,J=2.5,0.7Hz,1H),8.12(d,J=1.5Hz,1H),8.15(d,J=1.5Hz,1H)
Ⅰg-10 1H NMR(300MHz,CDCl3)δ1.77(s,3H),1.79(s,6H),1.83(s,3H),2.07(s,3H),2.09(s,3H),3.34(s,3H),3.41(s,3H),3.99(t,J=5.7Hz,2H),4.62(brs,1H),4.88(d,J=6.9Hz,2H),5.34-5.42(m,1H),5.55-5.62(m,1H),6.84(dd,J=8.4,0.8Hz,1H),7.53(dd,J=8.4,2.5Hz,1H),8.02(d,J=1.5Hz,1H),8.09(dd,J=2.5,0.8Hz,1H)
实验1  对小鼠脾细胞体外促有丝分裂活性的抑制作用
将悬浮于0.1ml 10％胎牛血清-强化RPMI1640培养基(含有2mM碳酸氢钠、50单位/ml青霉素、50μg/ml链霉素和5×10-5M 2-巯基乙醇)中的5×105C3H/HeN小鼠脾细胞加入到96-孔微量滴定板中。然后，将作为有丝分裂原的5μg/ml伴刀豆凝集素(ConA)或10μg/ml脂多糖(LPS)和预先-确定浓度的本发明化合物加入每孔中，以使每孔的终体积达到0.2ml。将本发明的每种化合物溶于二甲亚砜(DMSO)中并用上面的RPMI1640培养基稀释，以使终浓度调为100ng/ml或以下。将96孔微量滴定板中的脾细胞在维持湿度100％、5％二氧化碳和95％空气的培养箱中于37℃培养3天。然后，将25μl的6mg/mlMTT{3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑鎓溴化物}(Sigma)加入每孔中并在相同的条件下于37℃培养4小时。培养后，将50μl 20％含有0.02N盐酸的十二烷基硫酸钠(SDS)加入到生成的甲_中，并使该混合物于37℃放置24小时以溶解甲_。用安装有570nm滤器的免疫读出仪(InterMed)测定生成的甲_的吸收强度(OD)相对于活细胞数的比例(免疫学方法杂志，65,55-63,1983)。从本发明化合物浓度和吸收强度之间的相关性计算细胞增殖的50％抑制浓度(IC50)。
实验2  对EL4细胞的抗增殖活性
将4×104/0.1ml小鼠胸腺瘤株EL4细胞加入到96-孔微量滴定板中，向其中加入0.1ml本发明化合物，以使浓度范围为0-5000ng/ml。培养3天后，通过如实验1所述的MTT方法计算IC50。
实验1和实验2的结果示于表141中。
                                     表141
化合物号 ConAIC50(ng/ml) LPSIC50(ng/ml) EL-4IC50(ng/ml)
   Ⅰa-2   ≤10   ≤10     33
   Ⅰa-42     16     31     200
   Ⅰa-43     74     154     500
   Ⅰa-45     66     373     811
   Ⅰa-66     52     39     80
   Ⅰa-94     12     21     50
   Ⅰb-3     41     145     307
   Ⅰb-13     58     179     426
   Ⅰb-16     3.1     6.7     400
   Ⅰb-17     29     60     78
   Ⅰb-20     51     196     576
   Ⅰb-23     78     283     651
   Ⅰb-37     92     361     114
   Ⅰb-40     16     55     60
   Ⅰb-44     60     317     426
   Ⅰb-54   ＜20     53     91
   Ⅰb-65     92     134     553
   Ⅰb-71     18     54     69
   Ⅰb-82   ＜20   ＜20   ＜20
   Ⅰb-101     42     261     493
   Ⅰc-1     48     158     473
   Ⅰc-14     15     53     207
如上所示，本发明化合物具有免疫抑制和抗过敏作用。
实验3  对抗卵清蛋白(OVA)的IgE产生的抑制效果
1)动物
使用购自Japan SLC,Inc.(Shizuoka)的BALB/c小鼠(雌性，8-10周龄)和Wistar大鼠(雌性，8-10周龄)。
2)免疫方法
通过腹膜内给予2μg卵清蛋白(OVA)和2mg氢氧化铝凝胶在生理盐水中的0.2ml悬浮液对BALB/c小鼠免疫。10天后，从心脏采血，然后分离血清，于-40℃贮存直至测定IgE抗体效价。
3)化合物
使本发明化合物溶解于或悬浮于N,N-二甲基乙酰胺中后，用miglyol 812中性油将该混合物稀释20倍。将获得的溶液以每只小鼠0.1ml(剂量40mg/kg)口服给予小鼠。从免疫接种的那一天至采血前一天持续给药10天。
4)抗-OVAIgE抗体效价(PCA效价)的测定
将获得的小鼠血清用生理盐水进行2-倍稀释，然后以各50μl溶液对预先去毛的Wistar大鼠背部皮肤进行皮内注射。24小时后，经静脉内注射含有1mg OVA和5mg Evans’蓝染料的0.5ml生理盐水来诱导被动皮肤过敏反应(PCA)。30分钟后处死大鼠，产生直径5mm或以上的蓝色的最高稀度记录为PCA效价。例如，当血清在达27倍稀度对PCA反应呈阳性时，小鼠的抗-OVAIgE抗体效价定义为7。结果示于表142中。
                                    表142
    化合物 PCA效价     化合物 PCA效价
   Ⅰa-356     5.3    Ⅰb-281     0
   Ⅰb-37     0    Ⅰb-283     3
   Ⅰb-69     1.5    Ⅰb-284     6.8
   Ⅰb-90     1.7    Ⅰb-285     2
   Ⅰb-218     5.5    Ⅰb-293     5
   Ⅰb-219   ＜0    Ⅰb-297     3
   Ⅰb-220   ＜0    Ⅰb-298     2.3
   Ⅰb-221     0.3    Ⅰb-299     0
   Ⅰb-222   ＜0    Ⅰb-301     3
   Ⅰb-223     3.8    Ⅰb-302     1.5
   Ⅰb-224     0    Ⅰb-305     3
   Ⅰb-225     0    Ⅰb-306     5.3
   Ⅰb-226     0    Ⅰb-307     5
   Ⅰb-227     4.5    Ⅰb-309     4.3
   Ⅰb-228     2.5    Ⅰb-310     5.8
   Ⅰb-229     3    Ⅰb-311     6.3
   Ⅰb-230     0    Ⅰb-312     0
   Ⅰb-231   ＜0    Ⅰb-322     4
   Ⅰb-232     1    Ⅰb-329     3.8
   Ⅰb-233     2    Ⅰb-330     0.5
   Ⅰb-234   ＜0    Ⅰb-331   ＜0
   Ⅰb-235   ＜0    Ⅰb-332     2.3
   Ⅰb-239     0    Ⅰb-333   ＜0
   Ⅰb-240     0    Ⅰb-334   ＜0
   Ⅰb-241     0    Ⅰb-342   ＜0
   Ⅰb-242     1    Ⅰb-343     0
   Ⅰb-243     2.3    Ⅰb-344     0
   Ⅰb-244     0    Ⅰb-350     2.3
   Ⅰb-245     5.3    Ⅰb-351     2.8
   Ⅰb-246     0    Ⅰb-352   ＜0
   Ⅰb-247     0    Ⅰb-353     2.5
   Ⅰb-248     0    Ⅰb-354   ＜0
   Ⅰb-249     0    Ⅰb-358   ＜0
   Ⅰb-250     0    Ⅰb-361   ＜0
   Ⅰb-259     0    Ⅰb-396   ＜0
   Ⅰb-272     5.3    Ⅰb-431     6.5
   Ⅰb-279     1    Ⅰb-433     5.5
Ⅰb-280 0    Ⅰb-439     5.3
   Ⅰg-2     6.8
如上所示，本发明化合物具有抑制IgE产生的作用。
制剂实施例1
本发明化合物(Ⅰa-1)         15mg
淀粉                        15mg
乳糖                        15mg
结晶纤维素                  19mg
聚乙烯醇                    3mg
蒸馏水                      30ml
硬脂酸钙                    3mg
对上述所有组分(硬脂酸钙除外)进行均匀混合后，将该混合物粉碎并制粒，干燥并得到合适大小的颗粒。将硬脂酸钙加入颗粒中后，经模压形成片剂。
工业可用性
如以上实验所例举的，本发明化合物具有有效的免疫抑制和/或抗过敏活性。本发明化合物作为免疫抑制剂、抗过敏剂和/或IgE产生的抑制剂是非常有用的。

Claims (51)

1．式(Ⅰ)化合物、其盐或水合物：
I其中A环、B环和C环各自独立为任选取代的芳族碳环或可以与苯环稠合的任选取代的5-或6-元杂环，当A环、B环和/或C环为任选取代的5-元杂环时，W1、W2和/或W3表示键，X为-O-、-CH2-、-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基或-S(O)p-，其中p为0-2的整数，Y为氢、任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的酰基、任选取代的环烷基、任选取代的环烯基、任选取代的低级烷氧基羰基、任选取代的氨磺酰基、任选取代的氨基、任选取代的芳基或任选取代的5-或6-元杂环，当X为-CH2-时，Y可以是任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可以是任选取代的低级烷氧基羰基、任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，V1和V2之一为键，而另一个为键、-O-、-NH-、-OCH2-、-CH2O-、-CH=CH-、-C≡C-、-CH(OR2)-，其中R2为氢或低级烷基、-CO-或-NHCHR3-，其中R3为氢或羟基，及当V1和V2均为单键时，A环、B环和C环中至少一个为任选取代的芳族碳环和至少另一个为可以与苯环稠合的任选取代的5-或6-元杂环。
2．权利要求1的化合物、其盐或水合物，其中A环为任选取代的苯环。
3．权利要求1的化合物、其盐或水合物，其中B环为任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的噻吩环、任选取代的呋喃环、任选取代的吡唑环或任选取代的噁唑环。
4．权利要求1的化合物、其盐或水合物，其中C环为任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的异噁唑环、任选取代的吡唑环、任选取代的苯并噻唑环、任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环或任选取代的三唑环。
5．权利要求1的化合物、其盐或水合物，其中X为-O-或-NR1-，其中R1为氢、甲基或异戊二烯基。
6．权利要求1的化合物、其盐或水合物，其中Y为氢、任选取代的低级烷基、任选取代的低级链烯基、低级烷基磺酰基或任选取代的酰基。
7．权利要求1的化合物、其盐或水合物，其中V1和V2之一为单键，而另一个为单键、-O-或-NH-
8．权利要求1的化合物、其盐或水合物，其中A环为任选取代的苯环，B环为任选取代的苯环，任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的噻吩环、任选取代的呋喃环、任选取代的吡唑环或任选取代的噁唑环，C环是任选取代的苯环、任选取代的吡啶环、任选取代的嘧啶环、任选取代的哒嗪环、任选取代的吡嗪环、任选取代的异噁唑环、任选取代的吡唑环、任选取代的苯并噻唑环、任选取代的吗啉环、任选取代的哌嗪环、任选取代的咪唑环或任选取代的三唑环，X为-O-或-NR1-，其中R1为氢、甲基或异戊二烯基，Y为任选取代的低级烷基或任选取代的低级链烯基，及V1和V2之一为单键，而另一个为单键、-O-或-NH-。
9．权利要求1-8中任一项的化合物、其盐或水合物，其中A环、B环和C环中的两个为任选取代的苯环，而另一个为可与苯环稠合的任选取代的5-或6-元杂环。
10．用作免疫抑制剂的药用组合物，它包含权利要求1-9中任一项的化合物、其盐或水合物。
11．用作抗过敏剂的药用组合物，它包含权利要求1-9中任一项的化合物、其盐或水合物。
12．用作IgE产生抑制剂的药用组合物，它包含权利要求1-9中任一项的化合物、其盐或水合物。
13．权利要求1-9中任一项的化合物、其盐或水合物在用于抑制免疫应答或治疗和/或预防过敏性疾病的药物制备中的用途。
14．下式(Ib’)的化合物、其盐或水合物：
Ib’其中C环为可与苯环稠合的任选取代的5-或6-元杂环，当C环是5-元杂环时，W3表示键，X和X’各自独立为-O-、-CH2-、-NR1-(其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基)或-S(O)p-，其中p为0-2的整数，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基、任选取代的低级链炔基、任选取代的酰基、任选取代的环烷基、任选取代的环烯基、任选取代的低级烷氧基羰基、任选取代的氨基、任选取代的氨磺酰基、任选取代的芳基或任选取代的5-或6-元杂环，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3,R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R8、R9、R10和R11各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的环烷基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、任选取代的氨基甲酰基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，排除其中R8、R9、R10和R11都选自氢和卤素的化合物。
15．权利要求14的化合物、其盐或水合物，其中R4和R5各自独立为氢、卤素或低级烷氧基。
16．权利要求14的化合物、其盐或水合物，其中R4和R5之一为氢，而另一个为卤素。
17．权利要求14-16中任一项的化合物、其盐或水合物，其中R6和R7均为氢。
18．权利要求14的化合物、其盐或水合物，其中R8和R11各自独立为任选取代的低级烷基或任选取代的低级烷氧基。
19．权利要求14的化合物、其盐或水合物，其中R8和R11各自独立为甲基或甲氧基。
20．权利要求14、18和19中任一项的化合物、其盐或水合物，其中R9和R10各自独立为氢或任选取代的低级烷基。
21．权利要求14的化合物、其盐或水合物，其中R8和R11均为任选取代的低级烷基或R8和R11均为任选取代的低级烷氧基，及R9和R10均同时为氢或R9和R10均为任选取代的低级烷基。
22．权利要求14、16和21中任一项的化合物、其盐或水合物，其中C环为含有至少一个N原子的5-或6-元杂环。
23．权利要求14、16和21中任一项的化合物、其盐或水合物，其中C环为含有至少一个N原子的6-元杂环。
24．权利要求14、16和21中任一项的化合物、其盐或水合物，其中C环为任选取代的吡啶或任选取代的嘧啶。
25．式(Ia’)化合物、其盐或水合物：
Ia’其中B环为含有一个或两个杂原子的任选取代的5-或6-元环(其中取代基为卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，其中B环仅由卤素取代的化合物不包括在内，及当B环为5-元杂环时，W2为键，X、X’、Y和Y’如同权利要求14中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR'=CH-CH=CR’、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3,R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R12、R13、R14和R15各自独立为氢、卤素、羟基、任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级链烯基、任选取代的低级链烯基氧基、任选取代的酰氧基、羧基、任选取代的低级烷氧基羰基、任选取代的低级链烯基氧基羰基、任选取代的低级烷硫基、任选取代的低级链烯基硫基、任选取代的氨基、任选取代的氨基甲酰基、胍基、硝基、任选取代的低级烷基磺酰基、任选取代的低级烷基磺酰基氧基、任选取代的芳基磺酰基或任选取代的芳基磺酰基氧基，排除：
(ⅰ)其中Y和Y’同时为氢的化合物，
(ⅱ)其中Y和Y’中至少一个为任选取代的酰基的化合物，
(ⅲ)其中-X-Y和-X'-Y’中至少一个为未取代的低级烷氧基的化合物，及
(ⅳ)其中-X-Y和-X'-Y’同时为任选取代的低级烷氧基或由苯基取代的氨基的化合物。
26．权利要求25的化合物、其盐或水合物，其中R4和R5各自独立为氢、卤素或低级烷基。
27．权利要求25的化合物、其盐或水合物，其中R4和R5之一为氢，而另一个为卤素。
28．权利要求25-27中任一项的化合物、其盐或水合物，其中R6和R7均为氢。
29．权利要求25或27的化合物、其盐或水合物，其中B环为含有至少一个N原子的5-或6-元杂环。
30．权利要求25或27的化合物、其盐或水合物，其中B环为含有至少一个N原子的6-元杂环。
31．权利要求25或27的化合物、其盐或水合物，其中B环为任选取代的吡啶或任选取代的嘧啶。
32．权利要求25或27的化合物、其盐或水合物，其中R12、R13、R14和R15各自独立为氢、卤素或低级烷基。
33．权利要求14或25的化合物、其盐或水合物，其中X和X’之一为-O-，而另一个为-NR1-，其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基。
34．权利要求14或25的化合物、其盐或水合物，其中X和X’之一为-O-，而另一个为-NR1-，其中R1为氢、低级烷基或低级链烯基和Y和Y’各自独立为任选取代的低级烷基或任选取代的低级链烯基。
35．权利要求33或34的化合物、其盐或水合物，其中R1为氢。
36．权利要求14或25的化合物、其盐或水合物，其中-X-Y和-X’-Y’中之一为任选取代的低级烷基氨基或任选取代的低级链烯基氨基，而另一个为任选取代的低级烷氧基或任选取代的低级链烯基氧基。
37．权利要求14或25的化合物、其盐或水合物，其中-X-Y和-X’-Y’中之一为任选取代的低级烷基氨基或任选取代的低级链烯基氨基，而另一个为异戊二烯基氧基。
38．权利要求14的化合物、其盐或水合物，其中R4、R5、R6和R7各自独立为氢、卤素或低级烷基，R8和R11各自独立为氢、卤素、任选取代的低级烷基、任选取代的低级烷氧基或低级烷氧基羰基，R9和R10各自独立为氢、任选取代的低级烷基或任选取代的低级烷氧基，X和X’之一为-O-，而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或低级烷基羰基，Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基，和C环为任选取代的吡啶或任选取代的嘧啶。
39．权利要求14的化合物、其盐或水合物，其中X’为-O-、-NR1-或-S(O)p-和C环为含有一个或两个杂原子的任选取代的5-元杂环。
40．权利要求25的化合物、其盐或水合物，其中R4、R5、R6和R7各自独立为氢、卤素或低级烷基，R12、R13、R14和R15各自独立为氢、卤素或低级烷基，B环为任选取代的吡啶或任选取代的嘧啶(其中所述取代基为任选取代的低级烷基或任选取代的低级烷氧基)，X和X’之一为-O-，而另一个为-NR1-，其中R1为氢、低级烷基、低级链烯基或低级烷基羰基和Y和Y’各自独立为任选取代的低级烷基、任选取代的低级链烯基或任选取代的低级链炔基。
41．式(If’)的化合物、其盐或水合物：
Figure 9980434500091
If’其中B环和C环中之一为含有一个或两个杂原子的任选取代的5-或6-元杂环，而另一个为含有至少一个N原子的6-元杂环，其中B环的每一个取代基都选自氰基和卤素的化合物不包括在内，X、X’、Y、Y’和W3如同在权利要求14中的定义，W2如同在权利要求25中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR'=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR'-N=CH-，其中m是4或5,n是2或3,R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6和R7如同在权利要求14中的定义。
42．式(Ig’)的化合物、其盐或水合物：
Figure 9980434500101
Ig’其中A环和C环各自独立为含有一个或两个杂原子的任选取代的5-或6-元杂环，当A环为5-元杂环时，W1为键X、X’、Y、Y’和W3如同在权利要求14中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR'-N=CH-，其中m是4或5,n是2或3,R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R8、R9、R10和R11如同在权利要求14中的定义，其中R8、R9、R10和R11都选自氢和卤素的化合物不包括在内。
43．用作免疫抑制剂的药用组合物，它含有式(Ib’)化合物、其盐或水合物：
Ib’其中C环和W3如同在权利要求14中的定义，X和X’各自独立为-O-、-CH2-、-NR1-(其中R1为氢、任选取代的低级烷基、低级链烯基、低级烷基羰基或任选取代的低级烷氧基羰基)、-S(O)p-(其中p为0-2的整数)或单键，Y和Y’如同在权利要求14中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’-、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3,R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，当X’为单键时，Y’可为氢、羟基、卤素、硝基或氧代，R4、R5、R6、R7、R8、R9、R10和R11如同在权利要求14中的定义，其中R8、R9、R10和R11都选自氢和卤素的化合物不包括在内。
44．用作免疫抑制剂的药用组合物，它含有式(Ia’)化合物、其盐或水合物：
Ia’其中B环为含有一个或两个杂原子的任选取代的5-或6-元杂环，其中B环的每一个取代基都选自氰基和卤素的化合物不包括在内，当B环为5-元杂环时，W2为键，X、X’、Y和Y’如同权利要求14中的定义，R1可与Y或Y’一起形成-(CH2)m-、-(CH2)2-Q-(CH2)2-(其中Q为CH2、O、S或NR’)、-CR’=CH-CH=CR’、-CH=N-CH=CH-、-N=CH-N=CH-、-C(=O)-O(CH2)n-、-C(=O)-NR’-(CH2)n-或-C(=O)-NR’-N=CH-，其中m是4或5,n是2或3，及R’为氢、低级烷基或低级链烯基，当X为-CH2-时，Y可为任选取代的低级烷氧基，当X’为-CH2-时，Y’可为任选取代的低级烷氧基，当X为-O-或-NR1-时，Y可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X’为-O-或-NR1-时，Y’可为任选取代的低级烷氧基羰基，任选取代的低级烷基磺酰基或任选取代的芳基磺酰基，当X为-CH2-或-NR1-时，Y可为氢或卤素，当X’为-CH2-或-NR1-时，Y’可为氢或卤素，R4、R5、R6、R7、R12、R13、R14和R15如同在权利要求25中的定义，排除：
(ⅰ)其中-X-Y和-X'-Y’同时为未取代的低级烷基、任选取代的低级烷氧基或未取代的酰氧基的化合物，
(ⅱ)其中-X-Y和-X'-Y’中之一为甲基，而另一个为甲氧基的化合物，及
(ⅲ)其中-X'-Y’为氢或卤素和-X-Y为未取代的低级烷基、未取代的低级烷氧基或二(低级)烷基氨基的化合物。
45．用作免疫抑制剂的药用组合物，它含有权利要求41的式(If’)化合物、其盐或水合物。
46．用作免疫抑制剂的药用组合物，它含有权利要求42的式(Ig’)化合物、其盐或水合物。
47．用作抗过敏剂的药用组合物，它含有权利要求41的式(If’)化合物、权利要求42的式(Ig’)化合物、权利要求43的式(Ib’)化合物、权利要求44的式(Ia’)化合物、其盐或水合物。
48．用作IgE产生抑制剂的药用组合物，它含有权利要求41的式(If’)化合物、权利要求42的式(Ig’)化合物、权利要求43的式(Ib’)化合物、权利要求44的式(Ia’)化合物、其盐或水合物。
49．权利要求41的式(If’)化合物、权利要求42的式(Ig’)化合物、权利要求43的式(Ib’)化合物、权利要求44的式(Ia’)化合物、其盐或水合物在制备用于抑制免疫应答、治疗和/或预防过敏性疾病的药物中的用途。
50．抑制免疫应答的方法，该方法包括给予权利要求41的式(If’)化合物、权利要求42的式(Ig’)化合物、权利要求43的式(Ib’)化合物、权利要求44的式(Ia’)化合物、其盐或水合物。
51．治疗和/或预防过敏性疾病的方法，该方法包括给予权利要求41的式(If’)化合物、权利要求42的式(Ig’)化合物、权利要求43的式(Ib’)化合物、权利要求44的式(Ia’)化合物、其盐或水合物。
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US6562817B1 (en) 2003-05-13
CA2318368A1 (en) 1999-08-05
NZ506101A (en) 2003-06-30
KR20030048486A (ko) 2003-06-19
WO1999038829A1 (fr) 1999-08-05
KR100404358B1 (ko) 2003-11-03
HUP0103304A3 (en) 2002-10-28
IL137511A0 (en) 2001-07-24
NO20003706L (no) 2000-09-14
EP1052238A4 (en) 2007-05-02
AU742641B2 (en) 2002-01-10
KR20010034220A (ko) 2001-04-25
BR9908539A (pt) 2000-12-05
HUP0103304A2 (hu) 2002-02-28
JP3929700B2 (ja) 2007-06-13
RU2216533C2 (ru) 2003-11-20
NO20003706D0 (no) 2000-07-19
ID24959A (id) 2000-08-31
PL341984A1 (en) 2001-05-07
CN1231440C (zh) 2005-12-14
CA2318368C (en) 2007-09-11
AU1983799A (en) 1999-08-16
EP1052238A1 (en) 2000-11-15

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