CN114908358B8 - Preparation method and device of amphiphilic molecular layer - Google Patents

Preparation method and device of amphiphilic molecular layer Download PDF

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Publication number
CN114908358B8
CN114908358B8 CN202210391473.3A CN202210391473A CN114908358B8 CN 114908358 B8 CN114908358 B8 CN 114908358B8 CN 202210391473 A CN202210391473 A CN 202210391473A CN 114908358 B8 CN114908358 B8 CN 114908358B8
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solution
preparation device
electrode layer
flow channel
polar
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CN114908358A (en
CN114908358B (en
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杨秉达
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Kong Que Chengdu Technology Co ltd
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Kong Que Chengdu Technology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B15/00—Operating or servicing cells
    • C25B15/08—Supplying or removing reactants or electrolytes; Regeneration of electrolytes
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/17—Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/60—Constructional parts of cells

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Electrochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The invention relates to a preparation method and a preparation device for rapidly preparing an amphiphilic molecular layer, comprising the following steps: s1, providing a preparation device for preparing a plurality of amphiphilic molecule layers, wherein a plurality of micropores and flow channels capable of enabling solution to flow to the micropores are arranged in the preparation device, and the preparation device further comprises an electrode layer, so that the solution flowing into the micropores can be in contact with the electrode layer; s2, adding a first polar solution into the flow channel, so that the first polar solution enters at least one micropore and contacts with the electrode layer; s3, sequentially adding a film solution and a second polar solution into the flow channel, so that a meniscus is formed in the flow channel by the film solution; and S4, adding a second polar solution into the flow channel, so that the second polar solution pushes the membrane solution to move and flow through at least one micropore where the first polar solution contacts with the electrode layer, and amphiphilic molecules in the membrane solution form an amphiphilic molecule layer on the corresponding micropore. The method provided by the invention is simple and safe to operate, and the selected preparation device is low in production cost.
CN202210391473.3A 2022-04-14 2022-04-14 Preparation method and device of amphiphilic molecular layer Active CN114908358B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202410598638.3A CN118835255A (en) 2022-04-14 2022-04-14 Preparation method and device for multiple amphiphilic molecule layers
CN202210391473.3A CN114908358B8 (en) 2022-04-14 2022-04-14 Preparation method and device of amphiphilic molecular layer

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CN202210391473.3A CN114908358B8 (en) 2022-04-14 2022-04-14 Preparation method and device of amphiphilic molecular layer

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CN114908358A CN114908358A (en) 2022-08-16
CN114908358B CN114908358B (en) 2024-06-04
CN114908358B8 true CN114908358B8 (en) 2024-06-21

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117384486A (en) * 2023-02-10 2024-01-12 北京普译生物科技有限公司 Mixed bionic membrane and preparation method and application thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102072971A (en) * 2009-11-20 2011-05-25 复旦大学 Method for preparing lipid bilayer membrane in liquid phase in situ
WO2011154114A2 (en) * 2010-06-07 2011-12-15 Albert-Ludwigs-Universität Freiburg Method for producing a bilipid layer, and microstructure and measuring assembly
CN101932933B (en) * 2007-12-19 2014-01-01 牛津纳米孔技术有限公司 Formation of layers of amphiphilic molecules
CN104321441B (en) * 2012-02-16 2016-10-19 牛津楠路珀尔科技有限公司 The survey quantitative analysis of polymer
US9791432B2 (en) * 2015-03-20 2017-10-17 Genia Technologies, Inc. Serpentine flow channels for flowing fluids over chip sensors
CN104918696B (en) * 2012-10-26 2018-11-13 牛津楠路珀尔科技有限公司 The formation of membrane array and its device
CN107124908B (en) * 2014-10-17 2019-11-19 牛津纳米孔技术公司 Electric device with detachable part
CN110383065B (en) * 2017-03-14 2020-12-29 豪夫迈·罗氏有限公司 Nanopore well structure and method
CN113061531A (en) * 2021-06-03 2021-07-02 成都齐碳科技有限公司 Chip structure, chip assembly, film forming method, nanopore sequencing device and application
CN113070113A (en) * 2021-06-03 2021-07-06 成都齐碳科技有限公司 Chip structure, film forming method, nanopore sequencing device and application
CN113402768A (en) * 2021-07-06 2021-09-17 四川大学 Phospholipid double-layer membrane for nanopore sequencing and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5114702B2 (en) * 2005-07-29 2013-01-09 国立大学法人 東京大学 Method and apparatus for forming bilayer film by contact with amphiphilic monolayer
GB201202519D0 (en) * 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US11439708B2 (en) * 2014-10-06 2022-09-13 Lawrence Livermore National Security, Llc Nanotube trans-membrane channels mimicking biological porins

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101932933B (en) * 2007-12-19 2014-01-01 牛津纳米孔技术有限公司 Formation of layers of amphiphilic molecules
CN102072971A (en) * 2009-11-20 2011-05-25 复旦大学 Method for preparing lipid bilayer membrane in liquid phase in situ
WO2011154114A2 (en) * 2010-06-07 2011-12-15 Albert-Ludwigs-Universität Freiburg Method for producing a bilipid layer, and microstructure and measuring assembly
CN104321441B (en) * 2012-02-16 2016-10-19 牛津楠路珀尔科技有限公司 The survey quantitative analysis of polymer
CN104918696B (en) * 2012-10-26 2018-11-13 牛津楠路珀尔科技有限公司 The formation of membrane array and its device
CN109569458A (en) * 2012-10-26 2019-04-05 牛津楠路珀尔科技有限公司 It is used to form the device of the array of the volume containing polarizable medium
CN107124908B (en) * 2014-10-17 2019-11-19 牛津纳米孔技术公司 Electric device with detachable part
US9791432B2 (en) * 2015-03-20 2017-10-17 Genia Technologies, Inc. Serpentine flow channels for flowing fluids over chip sensors
CN110383065B (en) * 2017-03-14 2020-12-29 豪夫迈·罗氏有限公司 Nanopore well structure and method
CN113061531A (en) * 2021-06-03 2021-07-02 成都齐碳科技有限公司 Chip structure, chip assembly, film forming method, nanopore sequencing device and application
CN113070113A (en) * 2021-06-03 2021-07-06 成都齐碳科技有限公司 Chip structure, film forming method, nanopore sequencing device and application
CN113402768A (en) * 2021-07-06 2021-09-17 四川大学 Phospholipid double-layer membrane for nanopore sequencing and preparation method thereof

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CN118835255A (en) 2024-10-25
CN114908358A (en) 2022-08-16
CN114908358B (en) 2024-06-04

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Effective date of registration: 20240520

Address after: No. 1888 Huanhu East Road, Dongjiageng Town, Dongdong New Area, Chengdu City, Sichuan Province, 641400

Patentee after: Kong Que (Chengdu) Technology Co.,Ltd.

Country or region after: China

Address before: 510320 unit 602, 6th floor, No. 7, helix 4th Road, Guangzhou International Biological Island, Huangpu District, Guangzhou City, Guangdong Province

Patentee before: Guangzhou Kongque Gene Technology Co.,Ltd.

Country or region before: China

CI03 Correction of invention patent
CI03 Correction of invention patent

Correction item: Patentee|Address

Correct: Kong Que (Chengdu) Technology Co., Ltd.|No. 1888 Huanhu East Road, Dongjiageng Town, Dongdong New Area, Chengdu City, Sichuan Province, 641400

False: Guangzhou Kongque Gene Technology Co., Ltd.|510320 unit 602, 6th floor, No. 7, helix 4th Road, Guangzhou International Biological Island, Huangpu District, Guangzhou City, Guangdong Province

Number: 23-01

Page: The title page

Volume: 40

Correct: Kong Que (Chengdu) Technology Co., Ltd.|No. 1888 Huanhu East Road, Dongjiageng Town, Dongdong New Area, Chengdu City, Sichuan Province, 641400

False: Guangzhou Kongque Gene Technology Co., Ltd.|510320 unit 602, 6th floor, No. 7, helix 4th Road, Guangzhou International Biological Island, Huangpu District, Guangzhou City, Guangdong Province

Number: 23-01

Volume: 40

OR01 Other related matters
OR01 Other related matters