CN113049758A - Detection device is used in drug intermediate research and development with contrast function - Google Patents
Detection device is used in drug intermediate research and development with contrast function Download PDFInfo
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- CN113049758A CN113049758A CN202110370504.2A CN202110370504A CN113049758A CN 113049758 A CN113049758 A CN 113049758A CN 202110370504 A CN202110370504 A CN 202110370504A CN 113049758 A CN113049758 A CN 113049758A
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 238000001514 detection method Methods 0.000 title claims abstract description 13
- 229940079593 drug Drugs 0.000 title abstract description 12
- 238000012827 research and development Methods 0.000 title abstract description 7
- 238000012360 testing method Methods 0.000 claims abstract description 64
- 238000003825 pressing Methods 0.000 claims description 21
- 230000007246 mechanism Effects 0.000 claims description 15
- 230000009471 action Effects 0.000 claims description 5
- 230000005484 gravity Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 2
- 239000012450 pharmaceutical intermediate Substances 0.000 claims 7
- 239000007788 liquid Substances 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 10
- 238000007789 sealing Methods 0.000 abstract description 10
- 239000000203 mixture Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/06—Test-tube stands; Test-tube holders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Abstract
The invention discloses a detection device with a comparison function for drug intermediate research and development, which comprises a box body, wherein a rotating motor is vertically arranged at the bottom end inside the box body, and a placing rack is arranged at the upper end of the rotating motor; the placing frame comprises a movable disc and a fixed disc which are horizontally arranged and are parallel to each other, an output shaft of a rotating motor is connected with the fixed disc, the movable disc is positioned right above the fixed disc, a plurality of through holes are formed in the disc surface annular array of the movable disc, a plurality of blind holes which correspond to the through holes one by one are formed in the disc surface annular array of the fixed disc, and test tubes are placed in the through holes and the blind holes which correspond to the through holes from top to bottom; the liquid medicine detection rack is convenient to use, and the plurality of test tubes are annularly arranged in the rack, so that the liquid medicine can be conveniently contrasted and analyzed during detection; the test tubes can be fixed, so that the test tubes are prevented from shaking in the rotating process; in addition, the electric cylinder drives the sealing plate to move down and seal the test tube, so that liquid medicine in the test tube is prevented from being spilled in the rotating process, and the influence of external factors on the comparison result is greatly reduced.
Description
Technical Field
The invention relates to the technical field of drug detection, in particular to a detection device with a comparison function for research and development of a drug intermediate.
Background
The medical intermediate is actually some chemical raw materials or chemical products used in the process of synthesizing the medicine. The chemical product can be produced in a common chemical plant without the production license of the medicine, and can be used for synthesizing the medicine as long as the grade meeting the requirement is reached. In the production medicine midbody in-process, need carry out the composition to the medicine and detect, it is even to add the water mixture in the test tube with a plurality of medicines of treating usually (can be a plurality of differences treat the medicine of treating, also can be the same different dose treat the medicine of treating) and shake, carry out visual inspection earlier, then use the composition detector to carry out composition analysis to the medicine like spectral analyzer, but treat the sample of examining and carry out composition analysis, the sample of waiting to examine in this process receives the pollution easily, and the manual work shakes even inefficiency, the test tube is placed inconveniently, be unfavorable for contrasting the liquid medicine.
Disclosure of Invention
The invention aims to overcome the existing defects and provides a detection device with a comparison function for researching and developing a drug intermediate, which is convenient to use, and a plurality of test tubes are annularly arranged in a placing rack, so that comparison and analysis are convenient to perform during detection of liquid drugs; the test tubes can be fixed, so that the test tubes are prevented from shaking in the rotating process; in addition, the electric cylinder drives the sealing plate to move down and seal the test tube, so that liquid medicine in the test tube is prevented from being spilled in the rotating process, the influence of external factors on a comparison result is greatly reduced, and the problem in the background art can be effectively solved.
In order to achieve the purpose, the invention provides the following technical scheme: a detection device with a comparison function for drug intermediate research and development comprises a box body, wherein a rotating motor is vertically arranged at the bottom end inside the box body, and a placing frame is arranged at the upper end of the rotating motor; the test tube placing rack comprises a movable disc and a fixed disc which are horizontally arranged and are parallel to each other, an output shaft of a rotating motor is connected with the fixed disc, the movable disc is positioned right above the fixed disc, a plurality of through holes are formed in the disc surface annular array of the movable disc, a plurality of blind holes which are in one-to-one correspondence with the through holes are formed in the disc surface annular array of the fixed disc, and test tubes are placed in the through holes and the blind holes which are in up-and-down correspondence; a guide rod is fixed at the upper part of the center of the fixed disc, and the movable disc is matched with the guide rod; the upper part of the movable disc is provided with a pressing mechanism which corresponds to the test tubes one by one, and the pressing mechanisms act and press the corresponding test tubes under the action of the gravity of the movable disc;
each hold-down mechanism all includes the movable rod that the slope set up, and the one end of movable rod is articulated with the upper end of guide arm, and the other end of movable rod articulates there is the briquetting inconsistent with the test tube, and the pole body of movable rod articulates the one end that has the connecting rod, and the other end and the movable plate of connecting rod are articulated.
Preferably, the inside upper portion of box is equipped with and is used for the orificial shrouding of a plurality of test tubes, and the upper portion of box is vertical to be run through has electronic jar, and electronic jar's flexible end is connected with the shrouding.
Preferably, the opening of box is articulated to have the chamber door, and the chamber door is equipped with transparent window, the bottom four corners of box all is equipped with the support column.
Preferably, the inner walls of two opposite sides in the box body are provided with illuminating lamps; the outer wall of the box body is provided with a switch for controlling the rotating motor, the electric cylinder and the illuminating lamp.
Preferably, the hinge point of the connecting rod and the movable rod is close to the pressing block.
Preferably, the side of the pressing block facing the test tube is provided with an arc-shaped groove.
Preferably, the test tubes are provided with eight groups which are uniformly distributed around the center of the guide rod, and the pressing mechanisms are correspondingly provided with eight groups which are uniformly distributed around the center of the guide rod.
Preferably, the output shaft of the rotating motor is connected with the fixed disc through threads.
Compared with the prior art, the invention has the beneficial effects that: according to the detection device with the comparison function for research and development of the drug intermediate, the plurality of test tubes are annularly arranged in the placement frame, so that comparison and analysis are facilitated when liquid drugs are detected; in the placing process, due to the gravity action of the movable disc, the movable disc pulls one end of the movable rod to rotate around the guide rod through the connecting rod, so that one end of the pressing block extrudes and pushes out the test tube to fix the test tube, the test tube is prevented from shaking in the rotating process, and the test tube placing device can be suitable for test tubes of different specifications; in addition, the electric cylinder drives the sealing plate to move down and seal the test tube, so that liquid medicine in the test tube is prevented from being spilled in the rotating process, the liquid medicine is in a sealing state, and the influence of external factors on a comparison result is greatly reduced.
Drawings
FIG. 1 is a first schematic structural diagram of the present invention;
FIG. 2 is a second schematic structural view of the present invention;
FIG. 3 is a front view of the present invention;
FIG. 4 is a partial schematic view of the present invention;
FIG. 5 is a partial sectional view of the present invention;
fig. 6 is a top view of the hold-down mechanism of the present invention.
In the figure: 1 box, 1.1 chamber door, 1.2 support columns, 1.3 switches, 1.4 light, 2 racks, 2.1 activity dish, 2.2 test tubes, 2.3 fixed disks, 2.4 guide arms, 3 rotating electrical machines, 4 electronic jars, 4.1 shrouding, 5 hold-down mechanism, 5.1 briquetting, 5.2 connecting rods, 5.3 movable rods.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-6, the present invention provides a technical solution: a detection device with a comparison function for drug intermediate research and development comprises a box body 1, wherein a rotating motor 3 is vertically arranged at the bottom end inside the box body 1, a placing frame 2 is arranged at the upper end of the rotating motor 3, and the rotating motor 3 can drive the placing frame 2 to rotate; the placing rack 2 comprises a movable disc 2.1 and a fixed disc 2.3 which are horizontally arranged and are parallel to each other, an output shaft of a rotating motor 3 is connected with the fixed disc 2.3, the movable disc 2.1 is positioned right above the fixed disc 2.3, a plurality of through holes are arranged in the disc surface annular array of the movable disc 2.1, a plurality of blind holes which are in one-to-one correspondence with the through holes are arranged in the disc surface annular array of the fixed disc 2.3, test tubes 2.2 are placed in the through holes and the blind holes which are corresponding up and down, the test tubes 2.2 are inserted into the through holes and the blind holes, the sizes of the through holes and the blind holes are larger than those of the test tubes, the test tubes with different specifications can be placed to a certain extent, the test tubes 2; a guide rod 2.4 is fixed at the upper part of the center of the fixed disc 2.3, and the movable disc 2.1 is matched with the guide rod 2.4; the upper part of the movable disc 2.1 is provided with a plurality of pressing mechanisms 5 which are in one-to-one correspondence with the plurality of test tubes 2.2, under the action of the gravity of the movable disc 2.1, the plurality of pressing mechanisms 5 act and press the corresponding test tubes 2.2, the rotary motor 3 can drive the plurality of test tubes 2.2 on the fixed disc 2.3 to rotate when driving the fixed disc 2.3 to rotate, the liquid medicine is shaken uniformly, the plurality of pressing mechanisms 5 are used for pressing the corresponding test tubes 2.2, and the test tubes 2.2 are prevented from shaking in the rotating process;
in this embodiment, each hold-down mechanism 5 includes a movable rod 5.3 disposed obliquely, one end of the movable rod 5.3 is hinged to the upper end of a guide rod 2.4, the other end of the movable rod 5.3 is hinged to a pressing block 5.1 abutting against the test tube 2.2, the rod body of the movable rod 5.3 is hinged to one end of a connecting rod 5.2, the other end of the connecting rod 5.2 is hinged to a movable plate 2.1, due to the gravity action of the movable plate 2.1, the movable plate 2.1 pulls one end of the movable rod 5.3 to rotate around the guide rod 2.4 through the connecting rod 5.2, so that one end of the pressing block 5.1 extrudes and pushes out the test tube 2.2, and the test tube 2.2 is tightly clamped and fixed in a through hole of the movable plate 2.1 and a blind;
in order to avoid the liquid medicine in the test tube 2.2 from spilling, the upper part inside the box body 1 is provided with a sealing plate 4.1 for sealing the tube orifices of the plurality of test tubes 2.2, the upper part of the box body 1 vertically penetrates through an electric cylinder 4, the telescopic end of the electric cylinder 4 is connected with the sealing plate 4.1, the sealing plate 4.1 is made of soft materials such as rubber, the electric cylinder 4 drives the sealing plate 4.1 to move down and seal the tube orifices of the test tubes 2.2, the liquid medicine is in a sealing state, and the influence of external factors on a comparison result is greatly reduced;
in addition, the opening of the box body 1 is hinged with a box door 1.1, the box door 1.1 is provided with a transparent window for convenient observation, and four corners of the bottom of the box body 1 are provided with support columns 1.2;
in addition, the inner walls of two opposite sides in the box body 1 are provided with illuminating lamps 1.4 for illumination, which is beneficial to observation; the outer wall of the box body 1 is provided with a switch 1.3 for controlling the rotating motor 3, the electric cylinder 4 and the illuminating lamp 1.4;
in order to stress the pressing block 5.1, the hinged point of the connecting rod 5.2 and the movable rod 5.3 is close to the pressing block 5.1;
in order to enable one side surface of the pressing block 5.1 to be matched with the test tube 2.2, an arc-shaped groove is formed in the side surface, facing the test tube 2.2, of the pressing block 5.1;
the test tubes 2.1 are provided with eight groups which are uniformly distributed around the center of the guide rod 2.4, and the pressing mechanisms 5 are correspondingly provided with eight groups which are uniformly distributed around the center of the guide rod 2.4;
in order to conveniently detach and take down the placing rack 2, the placing rack can be taken out of the box body 1, and an output shaft of the rotating motor 3 is connected with the fixed disk 2.3 through threads.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The utility model provides a detection device is used in development of medicine midbody with contrast function, includes box (1), its characterized in that: a rotating motor (3) is vertically arranged at the bottom end inside the box body (1), and a placing frame (2) is arranged at the upper end of the rotating motor (3); the test tube placing rack (2) comprises a movable disc (2.1) and a fixed disc (2.3) which are horizontally arranged and are parallel to each other, an output shaft of a rotating motor (3) is connected with the fixed disc (2.3), the movable disc (2.1) is positioned right above the fixed disc (2.3), a plurality of through holes are formed in the disc surface annular array of the movable disc (2.1), a plurality of blind holes which correspond to the through holes one by one are formed in the disc surface annular array of the fixed disc (2.3), and test tubes (2.2) are placed in the through holes and the blind holes which correspond to each other up and down; a guide rod (2.4) is fixed at the upper part of the center of the fixed disc (2.3), and the movable disc (2.1) is matched with the guide rod (2.4); the upper part of the movable disc (2.1) is provided with a plurality of pressing mechanisms (5) which correspond to the test tubes (2.2) one by one, and under the action of the gravity of the movable disc (2.3), the pressing mechanisms (5) act and press the corresponding test tubes (2.2);
each hold-down mechanism (5) all includes movable rod (5.3) that the slope set up, and the one end of movable rod (5.3) is articulated with the upper end of guide arm (2.4), and the other end of movable rod (5.3) articulates has briquetting (5.1) inconsistent with test tube (2.2), and the pole body of movable rod (5.3) articulates the one end that has connecting rod (5.2), and the other end and activity dish (2.1) of connecting rod (5.2) are articulated.
2. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the inside upper portion of box (1) is equipped with and is used for sealed orificial shrouding (4.1) of a plurality of test tubes (2.2), and the upper portion of box (1) is vertical to be run through has electronic jar (4), and the flexible end and shrouding (4.1) of electronic jar (4) are connected.
3. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the opening of box (1) articulates there is chamber door (1.1), and chamber door (1.1) is equipped with transparent window, the bottom four corners of box (1) all is equipped with support column (1.2).
4. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the inner walls of two opposite sides in the box body (1) are provided with illuminating lamps (1.4); the outer wall of the box body (1) is provided with a switch (1.3) for controlling the rotating motor (3), the electric cylinder (4) and the illuminating lamp (1.4).
5. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: and the hinge joint of the connecting rod (5.2) and the movable rod (5.3) is close to the pressing block (5.1).
6. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the side of the pressing block (5.1) facing the test tube (2.2) is provided with an arc-shaped groove.
7. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the test tube (2.1) is equipped with eight groups and winds the center equipartition of guide arm (2.4), hold-down mechanism (5) correspond and are equipped with eight groups and wind the center equipartition of guide arm (2.4).
8. The test device for development of pharmaceutical intermediate having a contrast function according to claim 1, wherein: the output shaft of the rotating motor (3) is connected with the fixed disc (2.3) through threads.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110370504.2A CN113049758A (en) | 2021-04-07 | 2021-04-07 | Detection device is used in drug intermediate research and development with contrast function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110370504.2A CN113049758A (en) | 2021-04-07 | 2021-04-07 | Detection device is used in drug intermediate research and development with contrast function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113049758A true CN113049758A (en) | 2021-06-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110370504.2A Pending CN113049758A (en) | 2021-04-07 | 2021-04-07 | Detection device is used in drug intermediate research and development with contrast function |
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| CN (1) | CN113049758A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118320870A (en) * | 2024-06-13 | 2024-07-12 | 青岛启诚环境科技有限公司 | Environment detection sample storage container with cleaning function |
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Application publication date: 20210629 |