CN111918655B - 治疗患有慢性肾脏疾病的糖尿病受试者的方法 - Google Patents
治疗患有慢性肾脏疾病的糖尿病受试者的方法 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
Landscapes
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- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
期 | 肾功能状态 | eGFR |
1期 | 肾功能正常 | 90或更高 |
2期 | 肾功能轻度丧失 | 60至89 |
3A期 | 肾功能轻度至中度丧失 | 45至59 |
3B期 | 肾功能中度至重度丧失 | 30至44 |
4期 | 肾功能重度丧失 | 15至29 |
5期 | 终末期肾脏疾病(ESRD) | 小于15 |
Claims (45)
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PCT/US2019/035789 WO2019236844A1 (en) | 2018-06-06 | 2019-06-06 | Methods of treating subjects having diabetes with chronic kidney disease |
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CN111918655A CN111918655A (zh) | 2020-11-10 |
CN111918655B true CN111918655B (zh) | 2024-05-31 |
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EP (1) | EP3801542B1 (zh) |
JP (1) | JP2021529728A (zh) |
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CN (1) | CN111918655B (zh) |
AU (1) | AU2019282727A1 (zh) |
BR (1) | BR112020024643A2 (zh) |
CA (1) | CA3102412A1 (zh) |
ES (1) | ES2929994T3 (zh) |
IL (1) | IL279174A (zh) |
MX (1) | MX2020013210A (zh) |
PH (1) | PH12020551159A1 (zh) |
SG (1) | SG11202007172YA (zh) |
TW (1) | TWI846700B (zh) |
WO (1) | WO2019236844A1 (zh) |
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CN111163782A (zh) | 2017-10-02 | 2020-05-15 | 普克塞尔公司 | 治疗射血分数保留型心力衰竭的方法 |
CN111918655B (zh) | 2018-06-06 | 2024-05-31 | 博希尔公司 | 治疗患有慢性肾脏疾病的糖尿病受试者的方法 |
JP7266616B2 (ja) | 2018-06-14 | 2023-04-28 | ポクセル | 糖尿病の治療において使用するためのトリアジン誘導体を含むフィルムコーティング錠剤 |
US20230201169A1 (en) * | 2020-04-27 | 2023-06-29 | The Research Institute At Nationwide Children's Hospital | PPARy AGONISTS FOR TREATMENT OF KIDNEY DISEASE |
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US3287366A (en) | 1963-12-24 | 1966-11-22 | American Cyanamid Co | Novel 1, 2-dihydro-s-triazines |
JPS4864088A (zh) | 1971-12-13 | 1973-09-05 | ||
JPS5414986B2 (zh) | 1973-10-02 | 1979-06-11 | ||
DE69814151T2 (de) | 1997-12-12 | 2004-03-25 | Abbott Laboratories, Abbott Park | Triazin angiogenese-inhibitoren |
FR2804113B1 (fr) | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
GB0124953D0 (en) | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
FR2853650B1 (fr) | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
CN100451008C (zh) | 2004-01-20 | 2009-01-14 | 默克公司 | 抗糖尿病的唑烷二酮类和噻唑烷二酮类 |
DE602006014840D1 (de) | 2005-08-11 | 2010-07-22 | Sru Biosystems Inc | Beugungsbasierter sensor, der markierungsfreie bindungserkennung und fluoreszenz-verstärkung kombiniert |
FR2896159B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
FR2896157B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline. |
FR2896158B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'inhibiteurs de la hmg-coa reductase. |
FR2896161B1 (fr) | 2006-01-13 | 2008-04-04 | Merck Sante Soc Par Actions Si | Utilisation de derives de triazines pour fabriquer un medicament ayant un effet cicatrisant ou angiogenique. |
WO2008069222A1 (en) | 2006-12-05 | 2008-06-12 | Semiconductor Energy Laboratory Co., Ltd. | Plasma display panel and field emission display |
DE102007054416A1 (de) | 2007-11-13 | 2009-05-14 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5- Triazin-Derivaten für die Behandlungen von Erkrankungen, die mit dem Insulinresistenz-Syndrom assoziiert sind |
DE102008007314A1 (de) | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten |
HUE027532T2 (en) | 2008-05-23 | 2016-10-28 | Poxel Sas | Process for the preparation of 3,6-dihydro-1,3,5-triazine derivatives |
CN102112425B (zh) | 2008-07-29 | 2014-06-11 | 普克塞尔公司 | 通过控制粒径的结晶从对映体混合物中分离对映体组分的方法 |
JP5485292B2 (ja) * | 2008-12-12 | 2014-05-07 | ポクセル・エスアーエス | Ampk活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物 |
KR101623819B1 (ko) | 2008-12-12 | 2016-05-24 | 뽁셀 에스아에스 | 트리아진 유도체들과 인슐린의 조합물 및 당뇨병을 치료하기 위한 이의 용도 |
CN105147662A (zh) | 2009-02-13 | 2015-12-16 | 贝林格尔·英格海姆国际有限公司 | 包含吡喃葡萄糖基二苯基甲烷衍生物的药物组合物及其药物剂型、制备方法与用途 |
EP2411375B1 (en) | 2009-03-26 | 2013-08-28 | Poxel | Process for enantiomeric separation of racemic dihydro-1,3,5 triazines via preferential crystallization |
FR2948027A1 (fr) | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
EP2579879B1 (en) | 2010-06-09 | 2016-03-23 | Poxel | Triazine derivatives for delaying the onset of type 1 diabetes |
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CN111918655A (zh) | 2020-11-10 |
JP2021529728A (ja) | 2021-11-04 |
ES2929994T3 (es) | 2022-12-05 |
MX2020013210A (es) | 2021-02-26 |
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AU2019282727A1 (en) | 2020-11-26 |
KR20200130281A (ko) | 2020-11-18 |
US11266652B2 (en) | 2022-03-08 |
TW202015696A (zh) | 2020-05-01 |
IL279174A (en) | 2021-01-31 |
US20200215072A1 (en) | 2020-07-09 |
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